A kind of pulverizer applied to bulk drug

Abstract

The utility model discloses a kind of be applied to the comminuting device of crude drug, including base, control mechanism is installed in the upper portion of base, the control mechanism is connected with comminuting mechanism;Motor drive screw feeder feeds and comminutes to the comminuting mechanism.The control mechanism includes the control box being installed in the upper portion of base, switch is arranged on the control box, for starting or closing the comminuting mechanism;It also includes external frequency converter and control system, the frequency converter and the control system are connected with the comminuting mechanism and the control box by communication module or cable.The product granularity of device after grinding is finer, smallest can make material evenly reach 200 microns, can improve drug dissolution rate and bioavailability, enhance preparation uniformity and stability, expand drug dosage form and application range, can satisfy the demand of different customer groups, increase product added value and its sales volume.

Description

Technical Field

[0001] This utility model belongs to the technical field of mechanical processing, and in particular to a pulverizing device for raw pharmaceutical materials. Background Technology

[0002] The production process of active pharmaceutical ingredients (APIs) mainly includes synthesis, reaction, filtration, evaporation, granulation (pulverization), and packaging. The granulation (pulverization) process often uses traditional bottom-mounted motor pulverizers. These pulverizers have advantages such as high cost-effectiveness and simple structure, but they also have some disadvantages:

[0003] ① The motor is located at the bottom and drives the cutting blade to rotate. During cleaning, the motor needs to be cleaned while it is rotating, which poses a safety hazard. If cleaning is carried out while the machine is stopped, the equipment disassembly process is complicated, and water can easily enter the motor, causing equipment failure.

[0004] ②When a large amount of material enters the sorting hopper during the production process, it is necessary to manually feed the material in using a titanium roller, which can easily lead to slippage and other safety accidents such as mechanical impact.

[0005] ③ During long-term, high-load operation, external supports are prone to entering the product along with materials, leading to significant quality accidents.

[0006] ④ The equipment has a large production capacity, and the failure rate is high when it is used under overload conditions.

[0007] ⑤ The material is ground to a large particle size, which cannot meet the needs of high-end customers who require finer particle size.

[0008] In summary, designing a pulverizing device for the production of active pharmaceutical ingredients is a technical problem that urgently needs to be solved in this field. Utility Model Content

[0009] In response to the problems raised above, this utility model proposes a pulverizing device for pharmaceutical raw materials, the specific solution of which is as follows:

[0010] A pulverizing device for pharmaceutical raw materials includes a base, a control mechanism mounted on the base, and the control mechanism being connected to a pulverizing mechanism; a motor-driven screw feeder feeds and pulverizes the raw materials into the pulverizing mechanism.

[0011] Preferably, the control mechanism includes a control box mounted above the base, and a switch is provided on the control box for starting or stopping the crushing mechanism;

[0012] It also includes an external frequency converter and control system, which are connected to the crushing mechanism and the control box via a communication module or cable.

[0013] Preferably, the crushing mechanism includes a buffer chamber, a feeding valve, a water-cooled crushing chamber, and a discharge chamber connected in sequence from top to bottom;

[0014] The water-cooled pulverizing chamber is connected to the side of the control box. A rotor shaft is provided in the middle of the chamber. The rotor is rotatably installed in the water-cooled pulverizing chamber through the rotor shaft. The fixing component is installed on the circular hole of the rotor.

[0015] More preferably, the pulverizing mechanism further includes a screen installed inside the water-cooled pulverizing chamber, the screen surrounding the rotor.

[0016] More preferably, the water-cooled pulverizing chamber is provided with multiple mounting shafts at equal intervals along its edge, and the sintered filter element breather is connected to the mounting shafts.

[0017] More preferably, the upper and lower parts of the water-cooled pulverizing chamber are respectively equipped with separation stop safety contacts, which are connected to the control box.

[0018] Preferably, the inlet of the buffer bin and the outlet of the discharge bin are each provided with a removable sealing cover.

[0019] Preferably, the rotor is a multi-bladed blade, and the blade shape is a combination of a blade and a hammer.

[0020] More preferably, the rotor is made of duplex steel.

[0021] Preferably, omnidirectional wheels are installed at the four corners of the base.

[0022] The beneficial effects of this utility model are:

[0023] 1. Given the complex on-site environment, the powder is hygroscopic and corrosive, the frequency converter and its control system are placed externally, and only the switch buttons are left on the equipment. This avoids corrosion of components, reduces the failure rate, reduces the frequency of maintenance, extends the equipment life, and ensures production continuity and stability.

[0024] 2. The materials on site are hard, and ordinary cutting blades are prone to wear, deformation, or even breakage. Upgrading the rotor material to duplex steel, with its high strength, high toughness, and good wear resistance, can withstand greater cutting forces, reduce wear rate, extend replacement cycle, save costs, ensure stable cutting results, and improve product quality;

[0025] 3. Adding a sealing cover, motor and screw feeder above the buffer hopper can achieve accurate and stable feeding, prevent material leakage and dust, reduce equipment load, reduce the risk of damage, extend equipment life, and improve product quality and production efficiency;

[0026] 4. If the device does not shut down unexpectedly during operation, it may cause safety accidents. The addition of a separate shutdown safety contact can quickly trigger the shutdown mechanism when subjected to abnormal impact or displacement, avoiding equipment damage, material leakage and personnel injury, ensuring the safety of operators and reducing enterprise losses. Attached Figure Description

[0027] The technical solution of this utility model will be further described in detail below with reference to the accompanying drawings and embodiments. However, it should be understood that these drawings are designed for illustrative purposes only and are not intended to limit the scope of this utility model. In addition, unless otherwise specified, these drawings are intended only to conceptually illustrate the structural construction described herein and are not necessarily drawn to scale.

[0028] Figure 1 This is a plan view of the present invention;

[0029] Figure 2 This is a side view of the present invention;

[0030] Figure 3 This is an exploded view of the crushing mechanism in this utility model;

[0031] In the picture:

[0032] 1-Base; 2-Grinding mechanism; 201-Water-cooled grinding chamber; 202-Rotor shaft; 203-Fixing component; 204-Rotor; 205-Screen; 206-Mounting shaft; 207-Sintered filter element breather;

[0033] 3-Buffer bin; 4-Feed valve; 5-Discharge bin; 6-Separation stop safety contact; 7-Motor; 8-Screw feeder; 9-Wheel caster; 10-Control box; 11-Switch. Detailed Implementation

[0034] First, it should be noted that the specific structure, features, and advantages of this utility model will be described in detail below by way of examples. However, all descriptions are for illustrative purposes only and should not be construed as limiting the utility model in any way. Furthermore, any single technical feature described or implied in the embodiments mentioned herein, or any single technical feature shown or implied in the accompanying drawings, can still be arbitrarily combined or deleted among these technical features to obtain more other embodiments of this utility model that may not be directly mentioned herein. Additionally, for the sake of simplifying the drawings, the same or similar technical features may be indicated only in one place in the same drawing.

[0035] In this utility model, unless otherwise explicitly specified and limited, the terms "installation", "setting", "connection", "fixing", "screw connection", etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0036] The following is in conjunction with the appendix Figure 1 - Appendix Figure 3 This utility model is described in detail.

[0037] Example 1

[0038] As attached Figure 1 - Appendix Figure 3 As shown, a pulverizing device for raw pharmaceutical materials includes a base 1, a control mechanism mounted on the base 1, and the control mechanism being connected to a pulverizing mechanism 2; a motor 7 drives a screw feeder 8 to feed and pulverize materials into the pulverizing mechanism 2.

[0039] This application utilizes a commercially available screw feeder 8 and motor 7 to deliver the raw pharmaceutical material to the pulverizing mechanism 2. This method enables precise and stable feeding, avoiding problems such as high equipment load and uneven feeding that can easily lead to unstable equipment operation or even overload when the feed volume is large. Furthermore, considering the on-site environment and the hygroscopic and corrosive nature of the powder, improvements have been made to both the control mechanism and the pulverizing mechanism 2, which can reduce the equipment load and improve product quality and production efficiency.

[0040] Furthermore, in the embodiments, the control mechanism may include a control box 10 mounted above the base 1, and a switch 11 is provided on the control box 10 for starting or stopping the crushing mechanism 2.

[0041] It also includes an external frequency converter and control system, which are connected to the crushing mechanism 2 and the control box 10 via a communication module or cable.

[0042] In this embodiment, due to the complex on-site environment and the fact that the powder is hygroscopic and corrosive, the frequency converter and its control system are placed externally. Only the switch 11 button connected to the wire of the crushing mechanism 2 is retained. That is, the crushing device is in one room, and the frequency converter and control system are placed in another room. The two are connected by a communication module or an extended cable. This can avoid the dust generated from corroding the components in the frequency converter and control system, thereby reducing the failure rate, reducing the frequency of maintenance, extending the equipment life, and ensuring the continuity and stability of production.

[0043] Furthermore, in the embodiments, the crushing mechanism 2 may include a buffer chamber 3, a feeding valve 4, a water-cooled crushing chamber 201 and a discharge chamber 5 connected sequentially from top to bottom;

[0044] The water-cooled pulverizing chamber 201 is connected to the side of the control box 10. A rotor shaft 202 is provided in the middle of the chamber. The rotor 204 is rotatably installed in the water-cooled pulverizing chamber 201 through the rotor shaft 202. The fixing member 203 is installed on the round hole of the rotor 204.

[0045] In this embodiment, the buffer chamber 3 is used to temporarily store the raw materials to be pulverized from the screw feeder 8, ensuring that the water-cooled pulverizing chamber 201 will not stop due to insufficient supply during operation. At the same time, the accumulation of raw materials in the buffer chamber 3 helps to achieve uniform feeding and avoids excessive or uneven feeding caused by direct dumping of materials.

[0046] In another embodiment, a feeding port can be provided above the buffer chamber 3. The feeding port can be a hopper or can be directly connected to the raw materials produced by other production lines.

[0047] The feed valve 4 is used to precisely regulate the flow rate of material entering the pulverizer. With the cooperation of the screw feeder 8, by adjusting the opening and closing degree of the feed valve, it can be ensured that the raw material enters the water-cooled pulverizing chamber 201 at a constant or controllable speed, while preventing the raw material from being blocked inside the water-cooled pulverizing chamber 201 and avoiding the raw material from flowing back into the buffer chamber 3.

[0048] The rotor 204 of the water-cooled pulverizing chamber 201 is used to shred and crush the raw material into the required particle size at high speed. The rotation speed of the rotor 204 can be adjusted by an external frequency converter to achieve the pulverization requirements of the raw material with different hardness.

[0049] In this embodiment, the water-cooled pulverizing chamber 201 supports online cleaning and steam sterilization. The chamber itself is polished to ensure that there is no material deposition, making cleaning convenient and simple.

[0050] The rotor 204 is detachable for easy replacement. The top of the rotor 204 has a round hole on which a fixing component 203 is installed for connection to the rotor shaft 202. The fixing component 203 ensures a secure connection between the rotor 204 and the rotor shaft 202 and prevents the rotor 204 from falling off. The fixing component 203 can be a bolt, pin, etc.

[0051] The discharge hopper 5 is used to discharge the pulverized raw material for the next process. The discharged powder can be collected in a container or connected to a suction adapter for conveying to the next process. The suction adapter can be a conveyor belt, a screw feeder 8, etc.

[0052] Furthermore, in the embodiments, the pulverizing mechanism 2 may also include a screen 205 installed inside the water-cooled pulverizing chamber 201, the screen 205 surrounding the rotor 204.

[0053] In this embodiment, the screen 205 is used to control the particle size of the powder. Powder that meets the requirements can flow from the screen 205 to the discharge bin 5, while powder that does not meet the requirements will continue to be ground by the rotor 204.

[0054] Furthermore, in the embodiments, it can be considered that the water-cooled pulverizing chamber 201 is provided with a plurality of mounting shafts 206 at equal intervals along its edge, and the sintered filter element breather 207 is connected to the mounting shafts 206.

[0055] In this embodiment, the sintered filter element breather 207 is made of stainless steel with a pore size of 5μm to ensure that no dust leaks out during the crushing operation, and also to reduce the heat generated during crushing and exhaust gas.

[0056] It is preferable to install four sintered filter element breathers 207.

[0057] Furthermore, in the embodiments, it can be considered that the upper and lower parts of the water-cooled pulverizing chamber 201 are respectively equipped with separation stop safety contacts 6, and the separation stop safety contacts 6 are connected to the control box 10.

[0058] In this embodiment, if the water-cooled crushing chamber 201 fails to shut down unexpectedly, it could easily lead to a safety accident. Therefore, safety contact points 6 for separation shutdown are installed on the upper and side parts. When the water-cooled crushing chamber 201, buffer chamber 3, or discharge chamber 5 is subjected to abnormal impact or displacement, the remote external control system will control the control box 10 to issue a command, and the safety contact points 6 for separation shutdown will quickly trigger the shutdown mechanism to avoid equipment damage, material leakage, and personnel injury, thereby ensuring the safety of operators and reducing losses for the enterprise.

[0059] Furthermore, in the embodiments, the inlet of the buffer chamber 3 and the outlet of the discharge chamber 5 may be provided with removable sealing caps.

[0060] In this embodiment, the sealing cover allows the crushing mechanism 2 to form a completely enclosed space, and the water-cooled crushing chamber 201 can exhaust air through the sintered filter element breather 207, so that dust leakage is completely avoided during the entire operation process.

[0061] Furthermore, in the embodiments, the rotor 204 can be considered as a multi-bladed blade, the blade shape being a combination of a blade and a hammer.

[0062] In this embodiment, the rotor 204 preferably has 4 blades, each blade having a cutting edge on one side for cutting the raw material and a flat side for pounding the raw material.

[0063] Furthermore, in the embodiments, the rotor 204 can also be considered to be made of duplex steel.

[0064] In this embodiment, the rotor 204 is made of duplex steel, which has higher hardness and can easily grind raw pharmaceutical materials. The high strength, high toughness, and good wear resistance of duplex steel can withstand greater cutting forces, reduce wear rate, extend replacement cycle, save costs, ensure stable cutting effect, and improve product quality.

[0065] Furthermore, the use of duplex steel for the 205 screen could also be considered.

[0066] Furthermore, in the embodiments, it can be considered that omnidirectional wheels 9 are respectively installed at the four corners of the base 1.

[0067] In this embodiment, the caster wheel 9 can push the device to any position.

[0068] Operating instructions:

[0069] A pulverizing apparatus for use in pharmaceutical raw materials, used for grinding pharmaceutical raw materials, includes the following steps:

[0070] S1: Motor 7 drives screw feeder 8 to feed raw materials into buffer chamber 3 with the sealing cover removed, and feeds raw materials evenly into water-cooled pulverizing chamber 201 through feed valve 4. When the amount of raw materials in water-cooled pulverizing chamber 201 reaches a certain amount, the inlet of buffer chamber 3 and the outlet of discharge chamber 5 are sealed tightly with the sealing cover.

[0071] S2: Press the switch 11 of the control box 10 to start the water-cooled pulverizing chamber 201. The speed of the multi-blade blades of the water-cooled pulverizing chamber 201 is adjusted by the external control system and frequency converter. The blades and hammers on the blades cut and hammer the raw materials when rotating. The pulverized raw material powder falls into the discharge hopper 5 through the screen 205.

[0072] S3: Stop the water-cooled pulverizing chamber 201 by switching on switch 11, remove the sealing cap on the outlet of the discharge chamber 5, and send the ground raw material powder to the container placed below the discharge chamber 5.

[0073] This grinding method produces a finer particle size, with the smallest particle size reaching 200 micrometers. This improves drug dissolution rate and bioavailability, enhances formulation uniformity and stability, expands drug dosage forms and application range, meets the needs of different customer groups, and increases product added value and sales volume. Simultaneously, in the mixing process, the fine-particle-size active pharmaceutical ingredient can be mixed with other raw materials more quickly and uniformly, shortening mixing time and improving production efficiency.

[0074] The above embodiments have provided a detailed description of the present invention, but the content described is only a preferred embodiment of the present invention and should not be considered as limiting the scope of the present invention. All equivalent changes and improvements made in accordance with the claims of the present invention should still fall within the patent coverage of the present invention.

Claims

1. A pulverizing device for pharmaceutical raw materials, characterized in that: Includes a base (1), on which a control mechanism is installed, and the control mechanism is connected to the crushing mechanism (2); a motor (7) drives a screw feeder (8) to feed and crush the material to the crushing mechanism (2).

2. The pulverizing device for raw pharmaceutical materials according to claim 1, characterized in that: The control mechanism includes a control box (10) installed above the base (1), and a switch (11) is provided on the control box (10) for starting or stopping the crushing mechanism (2). It also includes an external frequency converter and control system, which are connected to the crushing mechanism (2) and the control box (10) via a communication module or cable.

3. The pulverizing device for raw pharmaceutical materials according to claim 2, characterized in that: The crushing mechanism (2) includes a buffer chamber (3), a feeding valve (4), a water-cooled crushing chamber (201), and a discharge chamber (5) connected from top to bottom. The water-cooled pulverizing chamber (201) is connected to the side of the control box (10). A rotor shaft (202) is provided in the middle of the chamber. The rotor (204) is rotatably installed in the water-cooled pulverizing chamber (201) through the rotor shaft (202). The fixing part (203) is installed on the round hole of the rotor (204).

4. A pulverizing device for raw pharmaceutical materials according to claim 3, characterized in that: The pulverizing mechanism (2) also includes a screen (205) installed inside the water-cooled pulverizing chamber (201), the screen (205) surrounding the rotor (204).

5. A pulverizing device for raw pharmaceutical materials according to claim 3, characterized in that: The water-cooled pulverizing chamber (201) has multiple mounting shafts (206) at equal intervals along its edge, and the sintered filter element breather (207) is connected to the mounting shafts (206).

6. A pulverizing device for raw pharmaceutical materials according to claim 3, characterized in that: The upper and lower parts of the water-cooled pulverizing chamber (201) are respectively equipped with separation stop safety contacts (6), which are connected to the control box (10).

7. A pulverizing device for raw pharmaceutical materials according to claim 3, characterized in that: The inlet of the buffer chamber (3) and the outlet of the discharge chamber (5) are respectively provided with removable sealing covers.

8. A pulverizing device for raw pharmaceutical materials according to claim 3, characterized in that: The rotor (204) is a multi-bladed blade, the blade shape being a combination of a blade and a hammer.

9. A pulverizing device for raw pharmaceutical materials according to claim 8, characterized in that: The rotor (204) is made of duplex steel.

10. A pulverizing device for raw pharmaceutical materials according to claim 1, characterized in that: The base (1) is equipped with casters (9) at its four corners.

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