A chromatographic column tube

Abstract

The utility model provides a kind of chromatographic column pipe, including column pipe body, the column pipe body includes column pipe screw head and pipe body, two groups the column pipe screw head is mutually symmetrical and is connected in the both ends of the pipe body;The outside wall of one end of the pipe body is equipped with discernment slot, and the inside of the pipe body is penetrated with pipe body inner hole;The inside of the column pipe screw head is fixedly connected with sieve plate at the both end openings of the pipe body inner hole, precision line pipe hole design, reduce connection dead volume, improve separation precision and analysis result accuracy;Stainless steel sieve plate shell cooperation overall structure, withstands 150MPa, adapts high pressure chromatography analysis scene;Conical surface makes blade annular variable seal, before end chamfer polishing hand twist structure, no risk of liquid leakage under high pressure;0.1 μm roughness mirror surface inner hole, molecule is not easy to stay, significantly improve separation rate and effect;Sieve plate gives consideration to " filter macromolecular impurities " and " large flow liquid passage ", adapt to multi-flow chromatography analysis demand.

Description

Technical Field

[0001] This utility model relates to a chromatographic column, specifically a chromatographic column tube, and belongs to the field of chromatographic analysis technology. Background Technology

[0002] Chromatographic columns are the core component of a chromatographic system, playing a crucial role in separating mixed components. A chromatographic column is a columnar container packed with a stationary phase for separating mixed components, typically made of metal or glass. Depending on its shape, it can be classified into various forms such as straight tubes, coiled tubes, and U-shaped tubes.

[0003] In chromatographic analysis, the chromatographic column is called the "heart of the chromatographic system" because the quality of separation depends mainly on the performance of the chromatographic column.

[0004] Traditional chromatographic columns have the following drawbacks:

[0005] The large size, insufficient precision in the design of the conduit holes, and large size of the connection parts interfere with the accuracy of sample separation.

[0006] Poor pressure resistance, insufficient strength of the outer shell material or structure, and easy deformation and leakage under high pressure (such as high pressure liquid chromatography).

[0007] The seals are unreliable, and most use flat / threaded seals. Under high pressure, there is a high risk of leakage, and the sealing performance deteriorates with long-term use.

[0008] The inner hole is rough and the polishing process is inadequate. The roughness is large and molecules are easily trapped on the pore wall, which not only affects the separation effect, but also easily contaminates the column tube.

[0009] Sieve plates are prone to clogging, and it is difficult to balance the "filtration accuracy" and "liquid flow capacity" of sieve plates. Either impurities penetrate or clogging occurs at high flow rates. To address this, a new chromatographic column is proposed. Utility Model Content

[0010] In view of this, the present invention provides a chromatographic column tube to solve or alleviate the technical problems of existing chromatographic column tubes such as "large volume, poor pressure resistance, poor sealing, rough inner hole, and easy clogging of sieve plate", and at least provides a beneficial alternative.

[0011] The technical solution of this utility model embodiment is implemented as follows: a chromatographic column tube includes a column tube body, the column tube body includes a column tube screw head and a tube body, and two sets of column tube screw heads are symmetrically connected to both ends of the tube body;

[0012] A positioning groove is provided on the outer wall of one end of the tube, and an inner hole is provided inside the tube.

[0013] The inside of the column tube screw head is fixedly connected to the two ends of the opening of the inner hole of the tube.

[0014] A further preferred embodiment has an internal thread section on the inner side wall of the end of the column screw head away from the sieve plate.

[0015] A further preferred embodiment: the internal part of the column screw head is provided with a conical cavity.

[0016] A further preferred embodiment: a conical cavity is provided at one end near the sieve plate.

[0017] A further preferred embodiment: both ends of the tube body are provided with external thread sections that are adapted to the screw heads of the column tube.

[0018] A further preferred embodiment: the two ends of the tube are provided with chamfered sections.

[0019] A further preferred embodiment: the outer shell of the sieve plate is made of stainless steel.

[0020] The present invention has the following advantages due to the adoption of the above technical solution:

[0021] 1. Small volume: Precise conduit hole design reduces dead volume at the connection, improving separation accuracy and the accuracy of analysis results.

[0022] 2. High pressure resistance: The stainless steel sieve shell and overall structure can withstand pressure up to 150MPa, making it suitable for high-pressure chromatography analysis.

[0023] 3. Reliable sealing: The conical surface makes the blade ring a seal, and the hand-tightening structure with the front end beveled and polished ensures no risk of leakage under high pressure.

[0024] 4. Excellent separation effect: The mirror-like inner pores with a roughness of 0.1μm make it difficult for molecules to be trapped, significantly improving the separation rate and effect.

[0025] 5. Excellent liquid flow properties of the sieve plate: The sieve plate combines "filtering large molecular impurities" with "high flow rate liquid flow", adapting to the needs of multi-flow chromatographic analysis.

[0026] The above overview is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of the present invention will become readily apparent from the accompanying drawings and the following detailed description. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0028] Figure 1 This is a cross-sectional view of the present invention;

[0029] Figure 2 This is a three-dimensional structural diagram of the column tube body of this utility model;

[0030] Figure 3 This is a structural diagram of the tube body of this utility model;

[0031] Figure 4 This is a schematic diagram of a partial assembly structure of the column tube screw head and tube body of this utility model;

[0032] Figure 5 This is a front view of the column tube body of this utility model.

[0033] Reference numerals: 10, column screw head; 101, internal thread section; 102, conical cavity; 103, conduit hole; 20, tube body; 201, positioning groove; 202, external thread section; 203, inner hole of tube body; 204, chamfered section; 30, sieve plate. Detailed Implementation

[0034] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of this invention. Therefore, the drawings and description are considered exemplary in nature and not restrictive.

[0035] The embodiments of this utility model will now be described in detail with reference to the accompanying drawings.

[0036] like Figures 1-5 As shown, this utility model embodiment provides a chromatographic column tube, including a column tube body, the column tube body including a column tube screw head 10 and a tube body 20, and two sets of column tube screw heads 10 are symmetrically connected to both ends of the tube body 20.

[0037] The outer wall of one end of the tube body 20 is provided with a positioning groove 201 to identify the direction of use and avoid incorrect installation. The tube body 20 has a tube inner hole 203 that is polished to a roughness of 0.1μm to form a mirror surface and reduce molecular retention.

[0038] The column tube screw head 10 is fixedly connected to the two ends of the opening of the inner hole 203 of the tube body. The sieve plate 30 is used to filter impurities in the chromatographic column feed and can allow a large flow of solution to pass through without clogging.

[0039] In this embodiment, specifically: an internal thread section 101 is provided on the inner side wall of the end of the column screw head 10 away from the sieve plate 30 for connecting external equipment.

[0040] In this embodiment, specifically: the inside of the column screw head 10 is provided with a conical cavity 102, which is set as a conical surface so that the connecting member blade ring can deform when the conical cavity 102 is compressed to achieve a seal.

[0041] In this embodiment, specifically: a conical cavity 102 is provided with a conduit hole 103 at one end near the sieve plate 30 for precise connection and with an extremely small diameter.

[0042] In this embodiment, specifically: both ends of the tube body 20 are provided with external thread sections 202 that are adapted to the column tube screw head 10, for threaded connection between the column tube screw head 10 and the tube body 20, which facilitates disassembly.

[0043] In this embodiment, specifically: the two ends of the tube body 20 are provided with chamfered sections 204. The front end is designed with a chamfer, and the contact surface is polished. It can be sealed by hand, which is convenient to operate.

[0044] In this embodiment, specifically: the outer shell of the sieve plate 30 is made of stainless steel, which enables the column tube body to withstand pressure up to 150MPa and work stably under high pressure.

[0045] The inner hole 203 of the column tube body is treated with multiple polishing processes to form a mirror surface;

[0046] The inner diameter of the inner hole 203 of the column body is 1.0 mm, which enables the detection of trace components that cannot be detected by large-diameter chromatographic columns.

[0047] The sieve plate 30 is a cup-shaped sieve plate with a conical sealing surface and screw engagement, which allows a large flow of solution to pass through while blocking large molecular impurities.

[0048] In summary, in practical use, the installation direction is determined by the positioning groove, and the conical surface and chamfered structure achieve reliable sealing; the sieve plate filters impurities, the mirror-like inner hole assists in separation, the high-pressure resistant structure is suitable for high-pressure conditions, the small volume design improves analytical accuracy, and the synergistic effect of each structure ensures the high efficiency and accuracy of chromatographic analysis.

[0049] The above description is merely a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in this utility model, and these should all be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the protection scope of the claims.

Claims

1. A chromatographic column, comprising a column body, characterized in that: The column tube body includes a column tube screw head (10) and a tube body (20), and two sets of column tube screw heads (10) are symmetrically connected to both ends of the tube body (20); The outer wall of one end of the tube (20) is provided with a positioning groove (201), and the inner hole (203) of the tube (20) is penetrated through the inside of the tube (20); The inside of the column screw head (10) is fixedly connected to the two ends of the inner hole (203) of the tube body with a sieve plate (30).

2. A chromatographic column tube according to claim 1, characterized in that: An internal thread section (101) is provided on the inner side wall of the end of the column screw head (10) away from the sieve plate (30).

3. A chromatographic column tube according to claim 1, characterized in that: The inside of the column screw head (10) is provided with a conical cavity (102).

4. A chromatographic column tube according to claim 3, characterized in that: A conical cavity (102) is provided with a conduit hole (103) at one end near the sieve plate (30).

5. A chromatographic column tube according to claim 1, characterized in that: The two ends of the tube body (20) are provided with external thread sections (202) that are compatible with the column screw head (10).

6. A chromatographic column tube according to claim 1, characterized in that: The two ends of the tube (20) are provided with chamfered sections (204).

7. A chromatographic column tube according to claim 1, characterized in that: The outer shell of the sieve plate (30) is made of stainless steel.

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