Water-soluble adhesive swab and collection assembly for DNA collection

Abstract

The application provides a water-soluble adhesive swab for DNA collection, which comprises a swab rod, a swab head and a water-soluble adhesive layer. The swab rod has a first end and a second end opposite to each other. The first end is used for clamping the swab rod. The swab head is a flocking layer covering the second end. The water-soluble adhesive layer covers the swab head and is used for bonding the sample to be collected. The application also provides a collection assembly. The water-soluble adhesive swab for DNA collection provided by the application can solve the problem of incomplete collection of target objects in smooth surfaces or gaps and the problem of detection interference caused by fiber residues. The collection assembly provided by the application has the advantages of the water-soluble adhesive swab and is also conducive to further reducing detection interference.

Description

Technical Field

[0001] This utility model relates to the technical field of biological experimental equipment, specifically to a water-soluble adhesive swab and collection component for DNA collection. Background Technology

[0002] Currently, in the field of forensic DNA, most methods for extracting trace amounts of DNA from different carriers involve wiping with cotton swabs or flocked swabs. However, these two existing extraction tools are prone to two problems: (1) on smooth surfaces or in crevices, the collection rate is low; (2) during the collection process, fiber residue can easily be left behind, interfering with the detection process. Utility Model Content

[0003] In order to overcome the shortcomings of the existing technology, the purpose of this utility model is to provide a water-soluble adhesive swab for DNA collection. This water-soluble adhesive swab can solve the problems of incomplete collection of target objects on smooth surfaces or in crevices, as well as the problem of detection interference caused by fiber residue.

[0004] This application also provides a collection assembly including the water-soluble viscous swab. In addition to possessing the advantages of water-soluble viscous swabs, the collection assembly also helps to further reduce detection interference.

[0005] To solve the above problems, the technical solution adopted by this utility model is as follows:

[0006] A water-soluble adhesive swab for DNA collection, comprising:

[0007] The swab handle has a first end and a second end opposite to each other, the first end being used for clamping the swab handle;

[0008] The swab head is a flocked layer covering the second end; and

[0009] A water-soluble adhesive layer is applied to the swab head, and the water-soluble adhesive layer is used to adhere the sample during collection.

[0010] In some possible implementations, the swab handle is a flexible handle, such that it can be bent until it breaks.

[0011] In some possible implementations, the swab handle has a break groove located on the side of the water-soluble adhesive layer near the first end, the break groove serving as a break point for the swab handle.

[0012] In some possible implementations, when viewed along the arrangement direction of the first end and the second end, the vertical cross-section of the swab rod has a structure that is narrow at both ends and wide in the middle, with the wide portion of the vertical cross-section positioned on the side of the water-soluble adhesive layer facing the first end, and the gap between the wide portion and the water-soluble adhesive layer serving as a break point.

[0013] In some possible implementations, the swab rod is a cylindrical rod.

[0014] This application also provides a collection component, which includes a protective sleeve and the aforementioned water-soluble adhesive swab for DNA collection. The protective sleeve includes a first sleeve portion and a second sleeve portion that are detachably connected, such that the protective sleeve has a first use state and a second use state. The first end is connected to the first sleeve portion, and the water-soluble adhesive layer protrudes from the first sleeve portion. In the first use state, the first sleeve portion and the second sleeve portion are connected to form a receiving cavity, and the structure of the water-soluble adhesive swab, except for the first end, is placed in the receiving cavity. In the second use state, the first sleeve portion and the second sleeve portion are detached, so that the water-soluble adhesive layer is exposed outside the protective sleeve.

[0015] In some possible implementations, the first sleeve and the second sleeve are threaded together.

[0016] In some possible implementations, the first sleeve includes:

[0017] The mounting part is detachably connected to the second set, the first end is mounted on the mounting part, and the water-soluble adhesive layer protrudes from the mounting part;

[0018] A gripping portion is provided at one end of the mounting portion opposite to the water-soluble adhesive layer; the gripping portion has a first receiving groove, the first receiving groove facing away from the water-soluble adhesive layer; and

[0019] Reinforcing ribs are connected to the sidewall and bottom wall of the first receiving groove, so that the first receiving groove is isolated into different cavities.

[0020] In some possible implementations, the second sleeve is provided with a second receiving groove, and when in the first use state, the first sleeve covers the second receiving groove to form the receiving cavity. The acquisition component further includes:

[0021] A mesh isolator is placed horizontally and fixed in the second receiving groove, so that the bottom of the second receiving groove forms an isolation cavity. When in the first use state, the mesh isolator is located on the side of the water-soluble adhesive layer away from the first sleeve.

[0022] A drying element is contained within the isolation cavity and is used to absorb moisture to keep the water-soluble viscous swab dry.

[0023] In some possible implementations, the mounting portion is provided with a socket, and the first end is fixed inside the socket.

[0024] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0025] In this application, by adding a water-soluble adhesive layer covering the swab head (flocked layer), the water-soluble adhesive swab can improve its adhesion, thereby adsorbing target objects (such as cells and DNA) on smooth surfaces (such as glass surfaces and metal surfaces), porous media (such as wood and fabrics), and in crevices (such as shoe creases, keyboard crevices, and data port crevices). Therefore, the water-soluble adhesive swab of this application can solve the problem of incomplete collection of target objects on smooth surfaces or in crevices. In addition, the water-soluble adhesive layer covering the swab head can also prevent flocked fibers from falling off, thus solving the problem of fiber residue causing detection interference. Furthermore, this application uses a water-soluble adhesive layer, which can be dissolved in an aqueous solution system, thereby facilitating the environmentally friendly release of target objects. In addition, the swab head formed by the flocked layer is soft and can form fiber contact points, thereby increasing friction to facilitate the release of small target objects such as cells and DNA for easier collection. This application also provides a collection assembly including this water-soluble adhesive swab. In addition to possessing the advantages of water-soluble adhesive swabs, the collection component also helps to further reduce detection interference.

[0026] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the structure of a swab rod provided in one embodiment of this application;

[0028] Figure 2 In order to be in Figure 1 The diagram shown illustrates the structure of the swab handle forming the swab head.

[0029] Figure 3 To form coverage Figure 2 The diagram shows the structure of the water-soluble adhesive layer of the swab head to obtain a water-soluble adhesive swab;

[0030] Figure 4 To be Figure 3 The diagram shows a water-soluble adhesive swab installed in the first part.

[0031] Figure 5 To assemble the second set of parts Figure 4 The diagram shows the structure of the first unit.

[0032] Figure 6 A schematic diagram of a water-soluble adhesive swab installed in the first sleeve according to another embodiment of this application;

[0033] Figure 7 This is a schematic diagram showing the connection between the second set of components and the grid isolation component.

[0034] Explanation of icon numbers:

[0035] 10 – Swab handle; 11 – First end; 12 – Second end; 101 – Break groove; 20 – Swab head; 30 – Water-soluble adhesive layer; 40 – Protective sleeve; 41 – First sleeve part; 411 – Mounting part; 412 – Grip part; 413 – Reinforcing rib; 410 – First receiving groove; 401 – Receiving cavity; 42 – Second sleeve part; 420 – Second receiving groove; 421 – Isolation cavity; 50 – Grid isolation element; 60 – Drying element. Detailed Implementation

[0036] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0037] The terms "first," "second," etc., in the specification, claims, and accompanying drawings of this application are used to distinguish different objects, not to describe a specific order. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. It should be noted that when an element is referred to as "fixed to" another element, it may be directly on the other element or there may be an intervening element. When an element is referred to as "connected to" another element, it may be directly connected to the other element or there may be an intervening element. When an element is referred to as "disposed on" another element, it may be disposed on the other element or there may be an intervening element.

[0038] One embodiment of this application provides a water-soluble adhesive swab for DNA collection. (See also...) Figures 1 to 3A water-soluble adhesive swab for DNA collection includes a swab handle 10, a swab head 20, and a water-soluble adhesive layer 30. The swab handle 10 has a first end 11 and a second end 12. The first end 11 is used to hold the swab handle 10; exemplarily, the first end 11 can be used for the operator to hold it or for fixing it within another fixture (e.g., a protective sleeve) to accommodate the swab handle 10. Exemplarily, the swab handle 10 can be a plastic handle, such as an ABS plastic handle, a PP plastic handle, or a PE plastic handle. The swab head 20 is a flocked layer covering the second end 12, formed using a known vertical fiber flocking technique; exemplarily, the fiber density gradient is 1200-800 fibers / mm². 2 For example, the fibers can be nylon fibers. A water-soluble adhesive layer 30 covers the swab head 20. For example, the swab head 20 can be immersed in a water-soluble adhesive to form the water-soluble adhesive layer 30. For example, the water-soluble adhesive layer 30 can also be bonded to the swab rod 10. For example, the water-soluble adhesive can be an existing adhesive, such as common polyvinyl alcohol adhesive or carboxymethyl cellulose adhesive. The water-soluble adhesive layer 30 is used to bond the sample to be collected (such as wood or fabric). Therefore, the target material (such as cells or DNA) carried by the sample can be directly bonded, thereby solving the problem of incomplete collection of target material from smooth surfaces or crevices. In addition, since the water-soluble adhesive layer 30 covers the swab head 20, the fibers of the flocked layer are less likely to detach from the swab rod 10, thus solving the problem of detection interference caused by fiber residue. In practical use, the water-soluble adhesive layer 30 on the surface of the swab head 20 is repeatedly applied to the sample to be collected. Then, the water-soluble adhesive layer 30 and part of the swab head 20 are placed in the extraction kit, so that the water-soluble adhesive layer 30 can dissolve in an aqueous solution system, such as Tris-HCl buffer or physiological saline, so that subsequent DNA extraction and detection can be carried out.

[0039] In this application, by additionally adding a water-soluble adhesive layer 30 covering the swab head 20 (flocked layer), the water-soluble adhesive swab can improve its adhesion, thereby adsorbing target objects (such as cells and DNA) on smooth surfaces (such as glass surfaces and metal surfaces), porous media (such as wood and fabrics), and in crevices (such as shoe crevices, keyboard crevices, and data port crevices). Therefore, the water-soluble adhesive swab of this application can solve the problem of incomplete collection of target objects on smooth surfaces or in crevices. In addition, the water-soluble adhesive layer 30 covering the swab head 20 can also prevent flocked fibers from falling off, thereby solving the problem of fiber residue causing detection interference. Furthermore, the water-soluble adhesive layer 30 used in this application can be dissolved in an aqueous solution system, which also facilitates the environmentally friendly release of target objects. In addition, the swab head 20 formed by the flocked layer is soft and can form fiber contact points, thereby increasing friction to facilitate the release of small target objects such as cells and DNA for easier collection.

[0040] In some embodiments, the swab rod 10 is a flexible rod, allowing it to be bent and broken. Therefore, after the water-soluble adhesive swab has been used for sampling, the swab head 20 and the water-soluble adhesive layer 30 can be partially broken off and placed into the extraction kit. Thus, the flexible and breakable nature of the swab rod 10 is beneficial for improving the size compatibility of the water-soluble adhesive swab with the extraction kit.

[0041] In some embodiments, the swab handle 10 has a break groove 101 located on the side of the water-soluble adhesive layer 30 near the first end 11. The break groove 101 serves as a break point for the swab handle 10. The break groove 101 helps reduce the breaking force, thereby improving ease of operation.

[0042] For example, the breakage groove 101 can be an annular groove or an arc-shaped groove. When viewed along the arrangement direction of the first end 11 and the second end 12, the annular groove bends in a single clockwise direction. For example, the number of breakage grooves 101 can be at least two. The above arrangement helps to further reduce the breaking force. It is understood that the number of breakage grooves 101 can also be one.

[0043] In some embodiments, when viewed along the arrangement direction of the first end 11 and the second end 12, in conjunction with a reference... Figure 6 The vertical cross-section of the swab rod 10 is narrow at both ends and wide in the middle. The wide part of the vertical cross-section is located on the side of the water-soluble adhesive layer 30 facing the first end 11, and the gap between the wide part and the water-soluble adhesive layer 30 serves as a break point. This break point setting can balance easy breakage with ensuring the bending strength of the swab rod 10, thereby allowing for greater wiping force to obtain the target object. This, in turn, is more conducive to improving the target object collection rate while ensuring that the swab rod 10 can be easily broken.

[0044] In some embodiments, the swab rod 10 is a cylindrical rod, which can be a cylindrical or irregular cylindrical rod. The shape of the swab rod 10 helps to reduce dimensional anisotropy, thereby facilitating rotational wiping sampling and thus improving the utilization rate of water-soluble viscous swabs.

[0045] Another embodiment of this application also provides a data acquisition component, in conjunction with reference to... Figures 3 to 5 The collection component includes a protective sleeve 40 and a water-soluble adhesive swab for DNA collection according to any of the above embodiments. The protective sleeve 40 includes a detachably connected first sleeve portion 41 and a second sleeve portion 42, allowing the protective sleeve 40 to have a first usage state and a second usage state. A first end 11 is connected to the first sleeve portion 41, and a water-soluble adhesive layer 30 protrudes from the first sleeve portion 41. In the first usage state, the first sleeve portion 41 and the second sleeve portion 42 are connected to form a receiving cavity 401, and the structure of the water-soluble adhesive swab, except for the first end 11, is placed within the receiving cavity 401. In the second usage state, the first sleeve portion 41 and the second sleeve portion 42 are detached, exposing the water-soluble adhesive layer 30 outside the protective sleeve 40. At this time, the water-soluble adhesive swab can be used to collect the target sample. After collecting the target object, the first set 41 and the second set 42 can be assembled to protect the water-soluble adhesive swab from contamination. Therefore, the collection component of this application has the advantages of water-soluble adhesive swabs and also helps to further reduce detection interference.

[0046] In some embodiments, refer to Figures 4 to 7 The first sleeve 41 and the second sleeve 42 are threaded together. For example, the first sleeve 41 may have an external thread structure, and the second sleeve 42 may have an internal thread structure. The external and internal thread structures are threaded together. It is understood that the first sleeve 41 may also have an internal thread structure, and the second sleeve 42 may have an external thread structure. This threaded, detachable connection improves connection strength and facilitates disassembly.

[0047] In another embodiment, a detachable connection can be achieved through a snap-fit ​​mechanism.

[0048] In some embodiments, refer to Figures 3 to 6The first sleeve 41 includes a mounting part 411, a gripping part 412, and a reinforcing rib 413. The mounting part 411 is detachably connected to the second sleeve 42. A first end 11 is mounted on the mounting part 411. In some embodiments, the mounting part 411 is provided with a socket (not shown), and the first end 11 is fixed in the socket, which facilitates easy assembly and disassembly. A water-soluble adhesive layer 30 protrudes from the mounting part 411. The gripping part 412 is located at the end of the mounting part 411 opposite to the water-soluble adhesive layer 30. The gripping part 412 has a first receiving groove 410 facing away from the water-soluble adhesive layer 30. The reinforcing rib 413 is connected to the side wall and bottom wall of the first receiving groove 410, thus isolating the first receiving groove 410 into different cavities. The first receiving groove 410, in conjunction with the reinforcing rib 413, helps to reduce the weight of the first sleeve 41 while ensuring strength.

[0049] In some embodiments, the number of reinforcing ribs 413 is at least three (three reinforcing ribs 413 are shown in the figure). The at least three reinforcing ribs 413 are joined end-to-end and end-to-end to the sidewall of the first receiving groove 410, such that adjacent reinforcing ribs 413, together with the bottom wall and sidewall of the first receiving groove 410, jointly isolate a cavity in the first receiving groove 410. The arrangement of a large number of reinforcing ribs 413 is more conducive to improving the strength of the first sleeve 41.

[0050] In some embodiments, refer to Figure 5 and Figure 6 The second sleeve 42 is provided with a second receiving groove 420. In the first use state, the first sleeve 41 covers the second receiving groove 420 to form a receiving cavity 401. The collection assembly also includes a grid separator 50 and a drying element 60. The grid separator 50 is placed horizontally and fixed in the second receiving groove 420, so that the bottom of the second receiving groove 420 forms an isolation cavity 421. In the first use state, the grid separator 50 is located on the side of the water-soluble adhesive layer 30 away from the first sleeve 41. The drying element 60 is contained within the isolation cavity 421 and is used to absorb moisture to keep the water-soluble adhesive swab dry. The drying element 60 helps to keep dry, thereby improving the preservation quality of the water-soluble adhesive swab. For example, the drying element 60 may include a conventional desiccant pack. The grid separator 50 helps to isolate the drying element 60 and the water-soluble adhesive layer 30 while also helping the drying element 60 to perform its drying function.

[0051] The above embodiments are merely preferred embodiments of this utility model and should not be construed as limiting the scope of protection of this utility model. Any non-substantial changes and substitutions made by those skilled in the art based on this utility model shall fall within the scope of protection claimed by this utility model.

Claims

1. A water-soluble viscous swab for DNA collection, characterized in that, include: The swab handle has a first end and a second end opposite to each other, the first end being used for clamping the swab handle; The swab head is a flocked layer covering the second end; as well as A water-soluble adhesive layer is applied to the swab head, and the water-soluble adhesive layer is used to adhere the sample during collection.

2. The water-soluble adhesive swab for DNA collection as described in claim 1, characterized in that, The swab handle is a flexible handle, allowing it to be bent until it breaks.

3. The water-soluble viscous swab for DNA collection as described in claim 2, characterized in that, The swab rod has a break groove located on the side of the water-soluble adhesive layer near the first end, and the break groove serves as the break point of the swab rod.

4. The water-soluble adhesive swab for DNA collection as described in claim 2, characterized in that, Viewed along the arrangement direction of the first end and the second end, the vertical cross-section of the swab rod has a structure that is narrow at both ends and wide in the middle. The wide part of the vertical cross-section is placed on the side of the water-soluble adhesive layer facing the first end, and the gap between the wide part and the water-soluble adhesive layer is used as a break point.

5. The water-soluble adhesive swab for DNA collection as described in any one of claims 1 to 4, characterized in that, The swab rod is a columnar rod.

6. A data acquisition component, characterized in that, The collection assembly includes a protective sleeve and a water-soluble adhesive swab for DNA collection as described in any one of claims 1 to 5. The protective sleeve includes a detachably connected first sleeve portion and a second sleeve portion, such that the protective sleeve has a first use state and a second use state. The first end is connected to the first sleeve portion, and the water-soluble adhesive layer protrudes from the first sleeve portion. In the first use state, the first sleeve portion and the second sleeve portion are connected to form a receiving cavity, and the structure of the water-soluble adhesive swab, except for the first end, is placed in the receiving cavity. In the second use state, the first sleeve portion and the second sleeve portion are detached, so that the water-soluble adhesive layer is exposed outside the protective sleeve.

7. The acquisition component as described in claim 6, characterized in that, The first sleeve and the second sleeve are threaded together.

8. The acquisition component as described in claim 6 or 7, characterized in that, The first set includes: The mounting part is detachably connected to the second set, the first end is mounted on the mounting part, and the water-soluble adhesive layer protrudes from the mounting part; A gripping portion is provided at one end of the mounting portion opposite to the water-soluble adhesive layer; the gripping portion has a first receiving groove, the first receiving groove facing away from the water-soluble adhesive layer; and Reinforcing ribs are connected to the sidewall and bottom wall of the first receiving groove, so that the first receiving groove is isolated into different cavities.

9. The acquisition component as described in claim 6, characterized in that, The second sleeve is provided with a second receiving groove. When in the first use state, the first sleeve covers the second receiving groove to form the receiving cavity. The acquisition component further includes: A mesh isolator is placed horizontally and fixed in the second receiving groove, so that the bottom of the second receiving groove forms an isolation cavity. When in the first use state, the mesh isolator is located on the side of the water-soluble adhesive layer away from the first sleeve. A drying element is contained within the isolation cavity and is used to absorb moisture to keep the water-soluble viscous swab dry.

10. The acquisition component as described in claim 8, characterized in that, The mounting part is provided with a socket, and the first end is fixed in the socket.

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