A biological sample cryotube

Abstract

This utility model discloses a cryopreservation tube for biological samples, belonging to the field of biological sample preservation technology. The cryopreservation tube includes a tube body with an internal cavity, at least two interconnected vertical partitions disposed within the cavity of the tube body, the extension direction of the vertical partitions being parallel to the axis of the tube body, and adjacent vertical partitions forming longitudinally extending independent cavities; a limiting component is disposed on the outer wall of the vertical partitions, so that the outer wall of the vertical partitions forms a limiting constraint with the inner wall of the tube body; this utility model can place vertical cylindrical biological samples within independent cavities, ensuring that each sample has independent storage space and avoiding mutual compression and adhesion between samples.

Description

Technical Field

[0001] This utility model relates to the field of biological sample preservation technology, and in particular to a biological sample cryopreservation tube. Background Technology

[0002] Biobanks are a key guarantee for the rapid transformation of scientific research results into industry. In the process of organizing the collection, storage, distribution and processing of samples, ensuring the accurate recording of various data is crucial for scientific research. However, the quality of biological samples can be affected by a variety of factors, especially the storage method, which plays a decisive role in the subsequent distribution and processing. At present, biological samples are usually stored in special biological sample cryopreservation tubes to achieve low temperature preservation.

[0003] In existing technologies, traditional cryopreservation tubes are usually stored in a horizontal stacking manner to store cylindrical samples. This method has some problems, such as difficulty in sample identification and susceptibility to temperature fluctuations during retrieval. In particular, for vertical cylindrical biological samples such as tissue sections and organoids, this storage method can easily cause the samples to squeeze and stick together. Utility Model Content

[0004] The purpose of this invention is to solve the problem in the prior art that vertical columnar biological samples such as tissue sections and organoids will squeeze and stick together when stacked, and proposes a biological sample cryopreservation tube.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A cryopreservation tube for biological samples includes a tube body with an internal cavity, and further includes: at least two interconnected vertical partitions disposed within the cavity of the tube body, wherein the extending direction of the vertical partitions is parallel to the axis of the tube body, and an independent cavity extending longitudinally is formed between adjacent vertical partitions; and a limiting component disposed on the outer wall of the vertical partitions, so that the outer wall of the vertical partitions forms a limiting constraint with the inner wall of the tube body.

[0007] To facilitate the vertical placement of biological samples, preferably, the ratio of the cross-sectional area of ​​a single independent cavity to the cross-sectional area inside the tube is 6:1.

[0008] To accommodate different biological samples, the independent cavity is further defined as a rectangular cross-section cavity.

[0009] To facilitate the positioning of the vertical partition, preferably, the positioning assembly includes at least four positioning plates evenly distributed around the vertical partition, with the outer wall of the positioning plate abutting against the inner wall of the tube.

[0010] To increase the refrigerant contact area of ​​the vertical partition, a groove is further provided on the side of the vertical partition and the limiting plate near the inner wall of the pipe, and the groove extends along the length of the vertical partition.

[0011] To improve the stability of the vertical partition, preferably, the thickness of the vertical partition is 3:1 to the thickness of the tube body.

[0012] To facilitate sealing of the independent cavity, preferably, the vertical partition is provided with a connecting post, and the connecting post has a limiting hole. The limiting hole is slidably connected to a sealing disc through a connecting rod, and the bottom of the sealing disc is provided with a protrusion that matches the cross-sectional shape of the independent cavity.

[0013] To facilitate sealing of the pipe body and limiting of the sealing disc, preferably, the open end of the pipe body is threaded with a sealing cap, and the inner bottom of the sealing cap abuts against the outer wall of the sealing disc.

[0014] Compared with the prior art, the present invention provides a cryopreservation tube for biological samples, which has the following beneficial effects:

[0015] 1. This biological sample cryopreservation tube, through the interconnection of multiple sets of vertical partitions to form a longitudinally extending independent cavity, can place vertical cylindrical biological samples in the independent cavity, ensuring that each sample has an independent storage space and avoiding mutual compression and adhesion between samples;

[0016] 2. This biological sample cryopreservation tube, through the cooperation of vertical partitions and limiting plates, can form a stable and clearly defined sample storage space, which greatly improves the safety and integrity of biological samples during the cryopreservation process.

[0017] 3. This biological sample cryopreservation tube has grooves on the side of the vertical partition and the limiting plate near the inner wall of the tube, which extend along the length of the vertical partition, thereby increasing the contact area of ​​the refrigerant and improving the cooling rate.

[0018] The parts of this device not described herein are the same as or can be implemented using existing technologies. This invention can place vertical cylindrical biological samples in an independent cavity, ensuring that each sample has an independent storage space and avoiding mutual compression and adhesion between samples. Attached Figure Description

[0019] Figure 1 This is a three-dimensional structural diagram of a biological sample cryopreservation tube proposed in this utility model;

[0020] Figure 2 This is a cross-sectional structural diagram of a biological sample cryopreservation tube proposed in this utility model;

[0021] Figure 3This is a partial structural diagram of a biological sample cryopreservation tube proposed in this utility model. Figure 1 ;

[0022] Figure 4 This is a partial structural diagram of a biological sample cryopreservation tube proposed in this utility model. Figure 2 .

[0023] In the diagram: 1. Pipe body; 101. Support foot; 2. Sealing cap; 201. Vertical groove; 3. Vertical strip partition; 301. Limiting plate; 4. Limiting hole; 5. Groove; 6. Sealing disc; 601. Protrusion; 7. Connecting rod. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0025] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0026] Biobanks are a key guarantee for the rapid transformation of scientific research results into industry. In the process of tissue sample collection, storage, distribution and processing, ensuring the accurate recording of various data is crucial for scientific research, especially the storage method, which plays a decisive role in the subsequent distribution and processing. At present, biological samples are usually stored in special biological sample cryopreservation tubes to achieve low temperature preservation. This device is adapted for the storage of vertical columnar biological samples such as tissue sections and organoids. It is mainly stored through a tube 1 with an internal cavity. Support feet 101 are set at the bottom of the tube 1, which can support it and also stably insert the tube 1 into the collection box on the table.

[0027] Example:

[0028] Reference Figures 1-4, A cryopreservation tube for biological samples. Inside the tube body 1, six groups of interconnected vertical strip partitions 3 are arranged. Four of the vertical strip partitions 3 are interconnected to form a structure similar to a "square" shape, and the extending direction of the vertical strip partitions 3 is parallel to the axis of the tube body 1. The other two vertical strip partitions 3 are located on the midlines of the above four vertical strip partitions 3. Thus, the six groups of vertical strip partitions 3 are interconnected to form independent cavities. The number of vertical strip partitions 3 can also be adjusted according to requirements so that they are connected to form multiple independent cavities. Vertical columnar biological samples can be placed in the independent cavities. This design ensures that each sample has an independent storage space, avoiding mutual extrusion and adhesion between samples. The material of the vertical strip partitions 3 can be selected as titanium alloy or low-temperature resistant plastic, enabling it to effectively resist deformation in a low-temperature environment and maintain the stability of the structure. Furthermore, it prevents the phenomenon of mutual extrusion and adhesion between vertical columnar biological samples such as tissue sections and organoids during storage.

[0029] In the above solution, through the interconnection of multiple groups of vertical strip partitions 3 to form longitudinally extending independent cavities, vertical columnar biological samples can be placed in the independent cavities. This design ensures that each sample has an independent storage space, avoiding mutual extrusion and adhesion between samples. And to ensure the stability of the vertical strip partitions 3, a limiting component is also provided on the outer wall of the vertical strip partitions 3, thereby forming a limiting constraint between the outer wall of the vertical strip partitions 3 and the inner wall of the tube body 1.

[0030] The above limiting component includes four limiting plates 301 circumferentially and evenly connected to the midline of the outer wall of the vertical strip partitions 3. The number of vertical limiting plates 301 can also be adjusted according to requirements so that they are connected to the outer wall of the vertical strip partitions 3. The outer wall of the limiting plates 301 abuts against the inner wall of the tube body 1. Each limiting plate 301 is perpendicularly arranged to the vertical strip partitions 3 to further enhance the stability of the vertical strip partitions 3 inside the tube body 1. In addition, the edge part of the limiting plate 301 is designed with a smooth transition. This not only reduces the friction with the inner wall of the tube body 1 but also facilitates the cleaning of the cryopreservation tube when needed. At the same time, the material of the limiting plate 301 is also selected as a low-temperature resistant material to ensure that it will not deform in a low-temperature storage environment and maintain the effectiveness of its limiting function. By the cooperation of the vertical strip partitions 3 and the limiting plates 301, a stable and clearly separated sample storage space can be jointly formed, greatly improving the safety and integrity of biological samples during cryopreservation. And on the side of the vertical strip partitions 3 and the limiting plates 301 close to the inner wall of the tube body 1, a groove 5 is opened. The groove 5 extends along the length direction of the vertical strip partitions 3. The groove 5 can increase the contact area with the refrigerant and improve the cooling rate.

[0031] The ratio of the cross-sectional area of ​​a single independent cavity to the internal cross-sectional area of ​​tube 1 is 6:1. This means that the interior of tube 1 is effectively divided into multiple relatively independent spaces, each of which can independently store a biological sample. This avoids cross-contamination between samples and improves the flexibility of sample storage. At the same time, this ratio design also ensures that the sample in each independent cavity can be cooled uniformly and quickly in a low-temperature storage environment to reach the ideal storage temperature.

[0032] The thickness ratio of the vertical partition 3 to the tube body 1 is 3:1. This design ensures that the vertical partition 3 has sufficient structural strength while minimizing its occupation of the internal space of the tube body 1. This thickness design makes the vertical partition 3 less prone to deformation when subjected to pressure in low-temperature environments, ensuring the stability and safety of the sample storage space. At the same time, the thinner vertical partition 3 also reduces the use of materials and lowers production costs, which is in line with the green and environmentally friendly design concept.

[0033] A connecting post is provided on the vertical partition 3, and a limiting hole 4 is opened on the connecting post. The limiting hole 4 is slidably connected to the sealing plate 6 through the connecting rod 7. The bottom of the sealing plate 6 is provided with a protrusion 601 that matches the cross-sectional shape of the independent cavity. When the connecting rod 7 on the sealing plate 6 is inserted into the connecting post, the protrusion 601 needs to be aligned with the independent cavity. When disassembling, the tube 1 can be inverted, so that each independent cavity can be sealed to prevent cross-contamination of samples during storage and effectively prevent the exchange of samples with the external environment, thus ensuring the long-term stability and safety of the samples.

[0034] The open end of the tube body 1 is threadedly connected to a sealing cap 2. The inner bottom of the sealing cap 2 abuts against the outer wall of the sealing disc 6. The tightness of the threaded connection further enhances the overall sealing effect, allowing the sealing cap 2 and the sealing disc 6 to cooperate and maintain a relatively good sealing state during the storage and transportation of the sample. This avoids direct contact between the sample and the external environment, thereby ensuring the purity and integrity of the sample. In addition, the sealing cap 2 is provided with vertical grooves 201, which allows users to quickly and conveniently open or close the sealing cap 2 when needed to access the sample inside the tube body 1, greatly improving work efficiency.

[0035] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A cryopreservation tube for biological samples, comprising a tube body (1) with an internal cavity, characterized in that, Also includes: At least two interconnected vertical partitions (3) are disposed within the cavity of the tube body (1). Among them, the extension direction of the vertical partition (3) is parallel to the axis of the tube body (1), and an independent cavity extending longitudinally is formed between adjacent vertical partitions (3); The limiting component is set on the outer wall of the vertical partition (3) so that the outer wall of the vertical partition (3) and the inner wall of the tube (1) form a limiting constraint.

2. The biological sample cryopreservation tube according to claim 1, characterized in that, The ratio of the cross-sectional area of ​​a single independent cavity to the cross-sectional area inside the tube (1) is 6:

1.

3. A cryopreservation tube for biological samples according to claim 2, characterized in that, The independent cavity is a rectangular cross-section cavity.

4. A cryopreservation tube for biological samples according to claim 1, characterized in that, The limiting component includes at least four limiting plates (301) evenly distributed around the vertical partition (3), the outer wall of the limiting plate (301) abutting against the inner wall of the tube (1).

5. A cryopreservation tube for biological samples according to claim 4, characterized in that, The vertical partition (3) and the limiting plate (301) have grooves (5) on the side near the inner wall of the tube body (1), and the grooves (5) extend along the length of the vertical partition (3).

6. A cryopreservation tube for biological samples according to claim 5, characterized in that, The thickness of the vertical partition (3) is 3:1 with the thickness of the tube body (1).

7. A cryopreservation tube for biological samples according to claim 1, characterized in that, The vertical partition (3) is provided with a connecting post, and a limiting hole (4) is opened on the connecting post. The limiting hole (4) is slidably connected to a sealing disc (6) through a connecting rod (7). The bottom of the sealing disc (6) is provided with a protrusion (601) that matches the cross-sectional shape of the independent cavity.

8. A cryopreservation tube for biological samples according to claim 7, characterized in that, The opening end of the tube (1) is threaded with a sealing cap (2), and the inner bottom of the sealing cap (2) abuts against the outer wall of the sealing disc (6).

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