A blood purification experimental device

Abstract

This utility model discloses a blood purification experimental device, relating to the field of blood purification technology, comprising: a constant temperature device for providing a constant temperature testing environment; a blood purifier, fixedly installed inside the constant temperature device, for simulating the blood purification process; an extracorporeal circulation pipeline connected to the blood purifier, the extracorporeal circulation pipeline being equipped with a flow meter for real-time monitoring of fluid flow parameters and a blood volume meter for real-time monitoring of fluid volume parameters; a liquid drive unit located on the extracorporeal circulation pipeline for driving fluid circulation within the blood purifier and the extracorporeal circulation pipeline; and a control device located outside the constant temperature device and electrically connected to the liquid drive unit, the flow meter, and the blood volume meter. The above-mentioned blood purification experimental device can accurately capture the coagulation state through two parameters: the percentage of flow deviation and the percentage of blood volume change. The measurement results are accurate and reliable, and the device has a high degree of automation.

Description

Technical Field

[0001] This utility model relates to the field of blood purification technology, and in particular to an experimental device for a blood purifier. Background Technology

[0002] Blood purification therapy is a vital means of saving the lives of patients with end-stage renal disease and other conditions. Post-dilution hemodialysis is widely used due to its high clearance efficiency, but the setting of its core parameter, the fractional filtration (FF), is crucial. An excessively high FF can lead to blood concentration, coagulation, and membrane fouling; an excessively low FF will prevent the filter from performing effectively, thus affecting treatment outcomes.

[0003] Currently, clinical practice mainly relies on healthcare professionals to set filtration fraction (FF) values ​​based on experience and assess coagulation risk by monitoring indirect indicators such as transmembrane pressure. However, transmembrane pressure monitoring is unstable and it is difficult to distinguish between true coagulation and concentration polarization, leading to inaccurate assessments and making it impossible to accurately find the optimal operating point (i.e., the optimal FF value) where the filter neither coagulates nor performs at its maximum efficiency.

[0004] Therefore, there are still shortcomings and deficiencies in the existing technology. How to provide a measuring device that can automatically and accurately determine the optimal performance of a blood purifier is a technical problem that urgently needs to be solved by those skilled in the art. Utility Model Content

[0005] The purpose of this invention is to provide a blood purifier experimental device, which solves the technical problem that currently, blood purifiers mainly rely on medical personnel to set the filtration fraction based on experience, making it impossible to accurately find the optimal working point where the filter neither clots blood nor exerts maximum efficiency.

[0006] To achieve the above objectives, this utility model provides a blood purification experimental device, comprising:

[0007] Temperature control device, used to provide a constant temperature testing environment;

[0008] A blood purifier is fixedly installed inside the constant temperature device to simulate the blood purification process;

[0009] An extracorporeal circulation tubing is connected to the blood purifier. The extracorporeal circulation tubing is equipped with a flow meter for real-time monitoring of fluid flow parameters and a blood volume meter for real-time monitoring of fluid volume parameters.

[0010] A liquid drive unit, located on the extracorporeal circulation tubing, is used to drive fluid to circulate in the blood purifier and the extracorporeal circulation tubing.

[0011] The control device is located outside the thermostat and is electrically connected to the liquid drive unit, the flow meter, and the blood volume meter.

[0012] Preferably, it further includes a valve assembly disposed in the extracorporeal circulation pipeline, the valve assembly being connected to the blood purifier and electrically connected to the control device.

[0013] Preferably, the valve assembly is a ball valve.

[0014] Preferably, the extracorporeal circulation circuit includes a first circuit and a second circuit. The two ends of the first circuit are respectively connected to the valve assembly and the blood purifier. One end of the second circuit is connected to the valve assembly, and the other end is connected to two branch pipes. The ends of the two branch pipes away from the second circuit are connected to the blood purifier.

[0015] Preferably, the liquid drive unit includes a blood pump and a filtrate pump, which are electrically connected to the control device.

[0016] Preferably, the blood pump is located in the first pipeline, and the filtrate pump is located in the second pipeline.

[0017] Preferably, the blood volume meter is installed in the first pipeline, and the flow meter is installed in the second pipeline.

[0018] Preferably, the constant temperature device is equipped with an electric heating tube, which is electrically connected to the control device, and the constant temperature device is also provided with a heating and insulation layer.

[0019] Preferably, the temperature control device is further equipped with a cooling fan.

[0020] Preferably, the control device integrates a display device, and the display device is provided with a human-machine interface.

[0021] Compared to the aforementioned background technology, the blood purifier experimental device provided by this utility model places the blood purifier in a constant temperature device. During the circulation process, the blood flow parameters are monitored in real time by a flow meter, and the blood volume parameters are monitored in real time by a blood volume meter. The control device receives the monitoring data and calculates the optimal filtration fraction of the blood purifier under test. The testing process is highly automated, reducing human error. Moreover, the two parameters, flow deviation percentage and blood volume change percentage, can be mutually verified, effectively eliminating interference such as concentration polarization, accurately capturing the coagulation state, and the measurement results are accurate and reliable. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the structure of the blood purifier experimental device provided in the embodiment of this utility model;

[0024] Figure 2 for Figure 1 A schematic diagram of the status of the valve assembly;

[0025] Figure 3 A schematic diagram of the blood purifier provided in this embodiment of the present invention during blood extraction;

[0026] Figure 4 for Figure 3 A schematic diagram of the status of the valve assembly;

[0027] Figure 5 for Figure 3 A schematic diagram of the valve assembly from another perspective;

[0028] Figure 6 This is a schematic diagram of the structure of the constant temperature device provided in an embodiment of the present invention.

[0029] Figures 1 to 6 Chinese figure labels: 1. Blood purifier; 2. Flow meter; 3. Blood pump; 4. Filtrate pump; 5. Control device; 6. Extracorporeal circulation tubing; 601. First tubing; 602. Second tubing; 603. Branch pipe; 7. Blood volume meter; 8. Liquid storage container; 9. Waste liquid tank; 10. Thermostat; 11. Valve assembly; 12. Second channel; 13. Purifier clamping device; 14. Tubing clamping device; 15. Cooling fan; 16. Heating insulation layer; 17. Handle; 18. Hinge; 19. Exhaust port; 20. Electric heating element; 21. Display device.

[0030] Figures 1 to 5 The direction of the middle arrow indicates the direction of fluid movement. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] To enable those skilled in the art to better understand the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0033] This invention provides a blood purification experimental device that can accurately capture coagulation status using two parameters: flow deviation percentage and blood volume change percentage. The measurement results are accurate and reliable, and the device is highly automated.

[0034] Please refer to this as well. Figures 1 to 2 The blood purification experimental device provided by this utility model includes:

[0035] Thermostat 10 is used to provide a constant temperature testing environment;

[0036] Blood purifier 1 is fixedly installed inside constant temperature device 10 to simulate the blood purification process;

[0037] Extracorporeal circulation tubing 6 is connected to blood purifier 1. Extracorporeal circulation tubing 6 is equipped with a flow meter 2 for real-time monitoring of fluid flow parameters and a blood volume meter 7 for real-time monitoring of fluid volume parameters.

[0038] A liquid drive unit, located on the extracorporeal circulation line 6, is used to drive fluid to circulate in the blood purifier 1 and the extracorporeal circulation line 6.

[0039] The control device 5 is located outside the thermostat 10 and is electrically connected to the liquid drive unit, flow meter 2 and blood volume meter 7.

[0040] Blood purifier 1 is the filter to be tested; specifically, a hemodialysis filter or a blood filter can be tested. To determine the optimal performance of blood purifier 1, it is first pre-rinsed, then placed in a constant temperature device 10. Under this constant temperature environment, the blood purification process is simulated, with blood circulating in the blood purifier 1 and the extracorporeal circulation tubing 6 connected to it. During circulation, flow meter 2 monitors the blood flow rate in real time, and blood volume meter 7 monitors the fluid volume in real time. Control device 5 receives the monitoring data and executes a predetermined algorithm program to automatically calculate the optimal filtration fraction of the blood purifier 1.

[0041] This setup ensures a high degree of automation in the testing process, reducing human error. Furthermore, the percentage of flow deviation and percentage of blood volume change can be used to verify each other, effectively eliminating interference from concentration polarization and accurately capturing the coagulation state, thus ensuring accurate and reliable test results.

[0042] Additionally, please refer to Figure 1 and Figure 6The thermostat 10 has a box-like structure. A door is provided on one side of the thermostat 10. The door is hinged to the thermostat 10 via a hinge 18. A handle 17 is provided on the door to facilitate opening and closing.

[0043] In some embodiments, please refer to the following: Figures 1 to 2 The blood purification experimental device provided by this utility model also includes a valve assembly 11 located in the extracorporeal circulation pipeline 6. The valve assembly 11 is connected to the blood purifier 1 and electrically connected to the control device 5.

[0044] The valve assembly 11 in the extracorporeal circulation pipeline 6 is used to control the cut-off or connection of fluid. The control device 5 is electrically connected to the valve assembly 11, and the valve assembly 11 can be remotely controlled to perform corresponding actions through the control device 5.

[0045] In some embodiments, please refer to the following: Figures 1 to 5 Valve assembly 11 is a ball valve. Figure 2 Taking the up, down, left, right, front, and back directions as an example, a ball valve includes five valve ports. Four valve ports are located on the four sides of the ball valve, and the fifth valve port is located on the rear side. By rotating the ball valve ball, the left, right, and upper valve ports can be connected, or the left, right, and lower valve ports can be connected. In addition to the first channel for connecting the left and right valve ports with the upper / lower valve ports, the ball valve ball also has a second channel 12 for connecting the rear valve port with the upper valve port.

[0046] In some embodiments, please refer to the following: Figures 1 to 2 The extracorporeal circulation tubing 6 includes a first tubing 601 and a second tubing 602. The two ends of the first tubing 601 are connected to the valve assembly 11 and the blood purifier 1, respectively. One end of the second tubing 602 is connected to the valve assembly 11, and the other end is connected to two branch pipes 603. The ends of the two branch pipes 603 away from the second tubing 602 are connected to the blood purifier 1.

[0047] The upper valve port of the ball valve is connected to the bottom of the blood purifier 1. The two ends of the first pipeline 601 are connected to the top of the blood purifier 1 and the left valve port of the ball valve, respectively. The end of the second pipeline 602 away from the branch pipe 603 is connected to the right valve port of the ball valve. One end of the two branch pipes 603 is connected to the second pipeline 602, and the other end is connected to the two outlets on the side of the blood purifier 1, respectively.

[0048] The following description, starting with blood entering the blood purifier 1 through the ball valve, illustrates the blood circulation process within the blood purifier 1 and the extracorporeal circulation tubing 6: Fluid enters the blood purifier 1 from the bottom through the upper valve port, then splits into three paths, entering the first tubing 601 and two branch pipes 603 from the top and sides of the blood purifier 1. Fluid entering the first tubing 601 passes through the left valve port of the ball valve into the ball valve itself, and finally enters the blood purifier 1 through the upper valve port. Simultaneously, fluid entering the two branch pipes 603 flows into the second tubing 602, then passes through the right valve port of the ball valve into the ball valve, and finally enters the blood purifier 1 through the upper valve port for the next cycle.

[0049] In some embodiments, please refer to the following: Figures 1 to 2 The liquid drive unit includes a blood pump 3 and a filter pump 4, which are electrically connected to a control device 5.

[0050] During the determination of the optimal performance of the blood purifier 1, the liquid drive unit provides power to drive the fluid to circulate in the blood purifier 1 and the extracorporeal circulation tubing 6.

[0051] In some embodiments, please refer to the following: Figures 1 to 2 Blood pump 3 is located in the first pipeline 601, and filtrate pump 4 is located in the second pipeline 602.

[0052] Blood pump 3 is installed in the first pipeline 601, and filtrate pump 4 is installed in the second pipeline 602. During the determination of the optimal performance of blood purifier 1, the working fluid driven by blood pump 3 flows between blood purifier 1 and the first pipeline 601, and the working fluid driven by filtrate pump 4 flows between blood purifier 1, the second pipeline 602 and the two branch pipes 603.

[0053] In some embodiments, please refer to the following: Figures 1 to 2 The blood volume meter 7 is installed in the first pipeline 601, and the flow meter 2 is installed in the second pipeline 602.

[0054] The blood volume meter 7 installed in the first pipeline 601 can monitor the blood volume parameters in real time, and the flow meter 2 installed in the second pipeline 602 can monitor the flow parameters of the fluid in real time. The percentage of flow deviation during blood circulation can be obtained by using the data provided by the blood volume meter 7 and the blood pump 3, and the percentage of blood volume change during blood circulation can be obtained by using the data provided by the flow meter 2 and the filter pump 4. Through mutual verification of the two parameters of flow deviation percentage and blood volume change percentage, the coagulation state can be accurately captured, ensuring that the measurement results are accurate and reliable.

[0055] In some embodiments, please refer to the following: Figures 1 to 2The constant temperature device 10 is equipped with an electric heating tube 20, which is electrically connected to the control device 5. The constant temperature device 10 is also provided with a heating and insulation layer 16.

[0056] The electric heating element 20 is the core heat-generating component. Its operation generates heat, raising the temperature inside the thermostat 10 to simulate the core temperature of the human body. The core temperature of the human body is constant at approximately 37°C. The electric heating element 20 converts electrical energy into heat energy, heating and maintaining the air and fluids inside the thermostat 10 at around 37°C. The heating insulation layer 16 provides thermal insulation, reducing heat loss.

[0057] In some embodiments, please refer to the following: Figures 1 to 2 , Figure 6 The constant temperature device 10 is also equipped with a cooling fan 15.

[0058] The cooling fan 15 and the electric heating element 20 work together to achieve and maintain a precise and stable temperature environment inside the thermostat 10. During the operation of the entire system, multiple components become heat sources. For example, the motors of the blood pump 3 and the filtrate pump 4 generate heat during prolonged operation. If there is only a heating function but no heat dissipation function, the heat generated by these devices will accumulate continuously, causing the internal temperature of the thermostat 10 to exceed the set target temperature. The cooling fan 15 is used to actively dissipate the excess heat, so that the internal temperature of the thermostat 10 is maintained at the target temperature.

[0059] To monitor the temperature inside the thermostat 10 in real time, a temperature sensor is installed inside the thermostat 10. The temperature sensor is electrically connected to the control device 5. The temperature sensor continuously monitors the actual temperature inside the thermostat 10 in real time and feeds it back to the control device 5. The control device 5 compares the measured actual temperature with the set temperature. When the measured actual temperature is lower than the set temperature, the electric heating tube 20 is activated to heat the device. When the measured actual temperature is higher than the set temperature, the electric heating tube 20 stops heating and the cooling fan 15 is activated as needed to prevent overheating. In this way, the thermostat 10 is kept at a constant temperature.

[0060] In some embodiments, please refer to Figure 6 The temperature control device 10 is also equipped with an exhaust port 19 on its top.

[0061] In some embodiments, please refer to the following: Figure 1 and Figure 6 The control device 5 integrates a display device 21, which has a human-machine interface.

[0062] The display device 21 can display test data such as the flow parameters monitored in real time by the flow meter 2, the blood volume parameters monitored in real time by the blood volume meter 7, and the test results such as the optimal filtration fraction of the blood purifier 1 under test, which are automatically calculated by the control device 5 after receiving the monitoring data. The human-machine interface includes, but is not limited to, a touch screen input module and a voice input / output module. Users can directly set parameters (such as target temperature, alarm threshold, etc.) and start / stop the test through the touch screen. Users can control the basic operation of the device through voice commands (such as "start test" and "stop"), and the device can also broadcast test results and alarm information through voice, realizing non-manual interaction.

[0063] The specific steps for conducting the test using the blood purifier experimental apparatus provided by this utility model are as follows:

[0064] 1. Collect 1000 ml of whole blood from a healthy cow. Collect the whole blood in a blood bag pre-filled with 1500 IU of heparin dissolved in a certain amount of saline solution, resulting in a final heparin concentration of 1.5 IU / mL; adjust the hematocrit (Hct) to 32%.

[0065] 2. Optionally, pre-rinse the blood purifier 1 to be tested with physiological saline solution (0.9% NaCl) for about 30 minutes;

[0066] After pre-rinsing, such as Figure 3 and Figure 5 As shown, first, the animal blood from step 1 is added to the storage container 8, and then the open-loop automatic blood dredging is performed, that is, the animal blood is introduced into the blood purifier 1 and the extracorporeal circulation pipeline 6. During blood collection, animal blood continuously flows from the storage container 8 through the rear and upper valve ports of the ball valve into the blood purifier 1, and then exits from the blood purifier 1. One path flows through the first pipeline 601, the left and lower valve ports of the ball valve into the waste liquid tank 9, while the other path flows through the second pipeline 602, the right and lower valve ports of the ball valve into the waste liquid tank 9. Blood collection lasts for 3 minutes, after which blood collection stops. At this time, the control device 5 controls the ball valve to connect the left, right, and upper valve ports. Finally, the blood purifier 1 and the extracorporeal circulation pipeline 6 are installed in the thermostat 10, and the internal temperature of the thermostat 10 is adjusted to 37°C to perform blood circulation testing. Specifically, the blood purifier 1 is fixed by the purifier clamping device 13, and the extracorporeal circulation pipeline 6 is fixed by the pipeline clamping device 14.

[0067] 3. For example Figure 1When performing the blood circulation test, the pump speed of the filtrate pump 4 is set to 250 mL / min by the control device 5. The control device 5 controls the reading of the blood pump 3 to control the flow rate of the flow meter 2 at 34 mL / min (i.e., filtration fraction (FF) = 20%). The control device 5 calculates the initial flow deviation ΔQ1 = (reading of blood pump 3 at 0 min - reading of flow meter 2 at 0 min). The control device 5 also calculates the blood volume deviation BV1 at t=0 min.

[0068] 4. After 15 minutes of circulation, the flow deviation ΔQ2 is calculated by the control device 5 as (the reading of blood pump 3 at 15 minutes - the reading of flow meter 2 at 15 minutes); at the same time, the flow rate of flow meter 2 is adjusted to 37 mL / min; the blood volume deviation BV2 at t=15 minutes is calculated by the control device 5.

[0069] 5. Calculate the flow deviation percentage %ΔQ = |(ΔQ2-ΔQ1)| / ΔQ1. Use control device 5 to ensure that the flow rate of flow meter 2 increases by 3 mL / min every 15 min until %ΔQ > 20%. Calculate the blood volume deviation percentage %ΔBV = (BV2-BV1) / BV1. Use control device 5 to ensure that the flow rate of flow meter 2 increases by 3 mL / min every 15 min until %ΔQ > 20% and %ΔBV > 10%, then stop the experiment and record the time point at this point as te.

[0070] 6. Define the filtration fraction at time tx = te - 15 min as the optimal filtration fraction of the blood purifier 1 under test.

[0071] It should be noted that in this specification, relational terms such as first and second are used only to distinguish one entity from several other entities, and do not necessarily require or imply any such actual relationship or order between these entities.

[0072] This article uses specific examples to illustrate the principles and implementation methods of this utility model. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made to this utility model without departing from the principles of this utility model, and these improvements and modifications also fall within the protection scope of this utility model.

Claims

1. A blood purification device experimental apparatus characterized by comprising: The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device.

2. The blood purification tester of claim 1, wherein, The application relates to a blood purification device.

3. The blood purification tester of claim 2, wherein, The application relates to a blood purification device.

4. The blood purification tester of claim 2, wherein, The application relates to a blood purification device.

5. The blood purification tester of claim 4, wherein, The application relates to a blood purification device.

6. The blood purification tester of claim 5, wherein, The application relates to a blood purification device.

7. The blood purification tester of claim 4, wherein, The application relates to a blood purification device.

8. The blood purification tester of claim 1, wherein, The application relates to a blood purification device.

9. The blood purification tester of claim 8, wherein, The application relates to a blood purification device.

10. The blood purification tester of claim 1, wherein, The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application relates to a blood purification device. The application rel

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