A stacked microchannel reactor for pharmaceuticals

Abstract

The utility model discloses a kind of laminated microchannel reactors for pharmacy, including reactor support, and temperature control conveying pipe fixedly installed in the inside upper portion of reactor support;Further include: the inside of the reactor support is provided with laminated mechanism, and laminated mechanism contains laminated locking rod, and the outside of laminated locking rod is provided with assembly support;The inside front of the reactor support is provided with reaction mechanism, and reaction mechanism contains reaction frame, and the inside of reaction frame is provided with temperature control coil pipe through setting.There is the laminated microchannel reactor for pharmacy, by the assembly support of the inside multiple slidable locking of reactor support is adjusted, to install for reaction frame, while by reaction baffle, reaction frame and temperature control coil pipe are sealed, and then accurate temperature control is carried out for drug raw materials, and reaction efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of microchannel reactor technology, specifically a stacked pharmaceutical microchannel reactor. Background Technology

[0002] A microchannel reactor is a continuous flow reaction device based on microfluidic technology, specifically designed for pharmaceutical process development and industrial production. Its core feature is its micron-scale channel structure, which achieves highly efficient mass and heat transfer through precision machining techniques. It is suitable for scenarios such as strongly exothermic reactions, rapid reactions, and nanoparticle preparation in drug synthesis. The utility model with announcement number CN222567721U discloses a pharmaceutical microchannel reactor, which includes several microchannel reaction modules. Several mixing mechanisms are provided on the sides of adjacent microchannel reaction modules, and a temperature control mechanism is provided at the bottom of the microchannel reaction modules. The microchannel reaction module includes a shell, and a left pressure plate, a middle plate and a right pressure plate are provided inside the shell. The left pressure plate, the middle plate and the right pressure plate are all connected to the shell. A first reaction zone is provided between the left pressure plate and the middle plate, and a second reaction zone is provided between the left pressure plate and the right pressure plate.

[0003] However, the microchannel reactors disclosed above for pharmaceutical use still have the following problems in actual use: By setting up multiple microchannel reaction modules and mixing mechanisms, the mixing efficiency between substances can be improved. However, such reactors are used for the preparation and processing of various drugs, so the required number of reactors and channels also varies. Multiple reactors are connected to each other in a stacked manner. When connecting, the reactors do not have corresponding positioning mechanisms and connection methods, resulting in small heat exchange area, low efficiency, and difficulty in achieving rapid and precise temperature control.

[0004] Therefore, we propose a stacked microchannel reactor for pharmaceutical applications to address the problems mentioned above. Utility Model Content

[0005] The purpose of this invention is to provide a stacked microchannel reactor for pharmaceutical applications. This addresses the problem that existing reactors, which improve mixing efficiency by setting up multiple microchannel reaction modules and mixing mechanisms, are used for the preparation and processing of various drugs, resulting in different numbers of reactors and channels required. Multiple reactors are interconnected by stacking, but there is no corresponding positioning mechanism or connection method, leading to a small heat exchange area, low efficiency, and difficulty in achieving rapid and precise temperature control.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a stacked pharmaceutical microchannel reactor, comprising a reactor support and a temperature-controlled delivery pipe fixedly installed inside and above the reactor support; further comprising: The reactor support is provided with a stacking mechanism inside, and the stacking mechanism includes a stacking locking rod, and the stacking locking rod is provided with an assembly frame outside. A reaction mechanism is provided at the front of the inside of the reactor support, and the reaction mechanism includes a reaction frame, with a temperature control coil running through the inside of the reaction frame.

[0007] Preferably, the stacking mechanism includes an assembly slot, and the inner side of the assembly slot is provided with stacking locking rods at equal intervals. The stacking locking rods are fixedly installed on the upper and lower sides inside the reactor support, and the assembly frame is limited by the assembly slot.

[0008] Preferably, the stacking mechanism includes limiting blocks, which are fixedly installed on the upper and lower sides of the inner side of the assembly frame. The limiting blocks are symmetrically arranged and each has a positioning slide rod that slides through them. The outer ends of the symmetrically arranged positioning slide rods are slidably inserted into the assembly slots inside the stacking locking rods to lock and position the equidistantly distributed assembly frames.

[0009] Preferably, the stacking mechanism includes an unlocking slide plate, which is fixedly installed on the inner end of a symmetrically arranged positioning slide bar, and the inner walls of the upper and lower unlocking slide plates are connected to each other by abutment springs, and the outer ends of the symmetrically arranged unlocking slide plates slide through the outside of the assembly frame.

[0010] Preferably, the reaction mechanism includes a transmission hose, which is symmetrically connected to the temperature control delivery pipe. The front ends of the symmetrically arranged transmission hoses are connected to the temperature control coil inside the reaction frame. The reaction frame is detachably installed on the front end of the assembly frame, realizing the stacked installation and positioning of the reaction frame inside the reactor support.

[0011] Preferably, the reaction mechanism includes reaction partitions, which are fixedly installed on the left and right sides inside the assembly frame. The reaction partitions form a sealed reaction space for the assembly frame. The reaction partitions are installed in pairs and are symmetrically distributed about the vertical central axis of the temperature control coil.

[0012] Preferably, the reaction mechanism includes a medium transfer pipe, which connects adjacent reaction partitions on the left and right sides, so that pharmaceutical raw materials are transported to the next reaction mechanism for reaction operations through the medium transfer pipe.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows: This stacked pharmaceutical microchannel reactor is adjustable through multiple sliding and locking assembly brackets inside the reactor support for the installation of the reaction frame. Simultaneously, a reaction baffle seals the reaction frame and the temperature control coil, thereby enabling precise temperature control of the pharmaceutical raw materials and improving reaction efficiency. The specific details are as follows: 1. By manually sliding the unlocking slide plates on the upper and lower sides of the assembly frame inward, the mounting plate compresses the spring and moves the positioning slide rod inward, so that the positioning slide rod and the assembly slot on the inner side of the stacked locking rod are disengaged. Then, the position of the assembly frame on the stacked locking rod is adjusted to accommodate multiple reaction frames for installation.

[0014] Furthermore, the internal contact spring of the assembly frame extends, causing the unlocking slide plate and positioning slide rod at both ends to slide outward synchronously, so that their outer ends are inserted into the assembly slot, thereby positioning the assembly frame with the front reaction frame.

[0015] 2. The reaction partitions on the outer sides of adjacent reaction frames are connected to each other through a medium transfer pipe. Pharmaceutical raw materials are transferred and mixed inside multiple reaction frames through the medium transfer pipe, and temperature-controlled liquid is delivered to multiple interconnected transfer hoses through a temperature-controlled delivery pipe, so as to accurately control the temperature of pharmaceutical raw materials when circulating inside the temperature-controlled coil, thereby improving reaction efficiency. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall three-dimensional structure of the present invention; Figure 2 This is a schematic diagram of the structure for installing the stacked locking rod of this utility model; Figure 3 This utility model Figure 2 Enlarged structural diagram at point A; Figure 4 This is a three-dimensional structural diagram of the reaction framework of this utility model; Figure 5 This is a schematic diagram of the installation structure of the temperature control coil of this utility model; Figure 6 This is a schematic diagram of the structure of the stacked locking rod and the mounting bracket of this utility model; Figure 7 This utility model Figure 6 Enlarged structural diagram at point B.

[0017] In the diagram: 1. Reactor support; 2. Temperature-controlled delivery pipe; 3. Stacked locking rod; 4. Assembly frame; 5. Reaction frame; 6. Temperature-controlled coil; 7. Assembly slot; 8. Limiting block; 9. Positioning slide bar; 10. Unlocking slide plate; 11. Contact spring; 12. Transfer hose; 13. Reaction partition; 14. Media transfer pipe. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] Please see Figures 1-7 The present invention provides the following technical solution: Example 1: To address the problems existing in the use of current multichannel reactors, this example discloses the following technical solution: a stacked pharmaceutical microchannel reactor, comprising a reactor support 1, an internal stacking mechanism, a stacking locking rod 3, and an external assembly bracket 4 for the stacking locking rod 3; the stacking mechanism includes an assembly slot 7, and the inner side of the stacking locking rod 3 is equally spaced in the assembly slot 7, and the stacking locking rod 3 is fixedly installed on the upper and lower sides inside the reactor support 1, limiting the assembly bracket 4 through the assembly slot 7.

[0020] The stacking mechanism includes limiting blocks 8, which are fixedly installed on the upper and lower sides of the inner side of the assembly frame 4. The limiting blocks 8 are symmetrically arranged, and each of them has a slidably inserted positioning slide rod 9. The outer ends of the symmetrically arranged positioning slide rods 9 are slidably inserted into the assembly slots 7 inside the stacking locking rod 3 to lock and position the equidistantly distributed assembly frame 4. The stacking mechanism includes unlocking slide plates 10, which are fixedly installed on the inner ends of the symmetrically arranged positioning slide rods 9. The inner walls of the upper and lower unlocking slide plates 10 are connected to each other by abutment springs 11. The outer ends of the symmetrically arranged unlocking slide plates 10 slide through the outside of the assembly frame 4.

[0021] like Figure 3 , Figures 6-7As shown, when it is necessary to adjust the position of multiple reaction frames 5 inside the reactor support 1, the unlocking slide plate 10 inside the assembly frame 4 is manually slid inward, causing the inner resisting spring 11 to be squeezed. Then, the positioning slide rod 9, which is fixedly connected to it, slides inward synchronously under the limit of the limiting block 8, and then disengages from the assembly slot 7 opened on the inner side of the stacked locking rod 3, so as to adjust the position of the assembly frame 4 on the outer wall of the stacked locking rod 3.

[0022] Furthermore, the extension of the abutment spring 11 inside the mounting bracket 4 causes the unlocking slide plate 10 and the positioning slide rod 9 to move outward and then re-insert into the corresponding mounting slot 7, thereby positioning and locking the reaction frame 5 in front of the mounting bracket 4.

[0023] Example 2: To address the problems existing in the use of existing multi-channel reactors, this example discloses the following technical solution, and a temperature-controlled delivery pipe 2 fixedly installed inside the upper part of the reactor support 1; a reaction mechanism is provided at the front of the reactor support 1, and the reaction mechanism includes a reaction frame 5, and a temperature-controlled coil 6 is provided through the inside of the reaction frame 5; the reaction mechanism includes a transmission hose 12, and the transmission hose 12 is symmetrically connected to the temperature-controlled delivery pipe 2, and the front end of the symmetrically arranged transmission hose 12 is connected through the temperature-controlled coil 6 inside the reaction frame 5, and the reaction frame 5 is detachably installed at the front end of the mounting bracket 4, realizing the stacked installation and positioning of the reaction frame 5 inside the reactor support 1.

[0024] The reaction mechanism includes reaction partitions 13, which are fixedly installed on the left and right sides inside the assembly frame 4. The reaction partitions 13 form a sealed reaction space for the assembly frame 4. The reaction partitions 13 are installed in pairs and are symmetrically distributed about the vertical central axis of the temperature control coil 6. The reaction mechanism includes a medium transfer pipe 14, which connects the adjacent reaction partitions 13 on the left and right sides, so that the pharmaceutical raw materials are transported to the next reaction mechanism for reaction operations through the medium transfer pipe 14.

[0025] like Figure 1 , Figures 4-5 As shown, by installing reaction partitions 13 on the left and right sides of the reaction frame 5, and connecting the reaction partitions 13 on the outer sides of adjacent reaction frames 5 through a through medium transfer pipe 14, the pharmaceutical raw materials are transferred and mixed inside multiple reaction frames 5 through the medium transfer pipe 14, and are sealed by the reaction partitions 13 to prevent spillage.

[0026] Furthermore, a temperature-controlled liquid is introduced into the temperature-controlled delivery pipe 2 installed above the inside of the reactor support 1, and the temperature-controlled delivery pipe 2 is connected to the reaction frame 5 through a transmission hose 12. The temperature-controlled liquid is delivered to the inside of the temperature-controlled coil 6 through the transmission hoses on the left and right sides, so as to accurately control the temperature of the raw materials for the pharmaceutical materials when flowing inside the temperature-controlled coil 6, thereby improving the reaction efficiency.

[0027] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A stacked pharmaceutical microchannel reactor, comprising a reactor support (1) and a temperature-controlled delivery pipe (2) fixedly installed inside the upper part of the reactor support (1). characterized in that Also includes: The reactor support (1) is provided with a stacking mechanism inside, and the stacking mechanism includes a stacking locking rod (3), and the stacking locking rod (3) is provided with an assembly frame (4) outside. The reactor support (1) has a reaction mechanism at the front inside, and the reaction mechanism includes a reaction frame (5), and a temperature control coil (6) is provided through the inside of the reaction frame (5).

2. A stacked microchannel reactor for pharmaceutical applications according to claim 1, wherein: The stacking mechanism includes an assembly slot (7), and the inner side of the assembly slot (7) is provided with stacking locking rods (3) at equal intervals. The stacking locking rods (3) are fixedly installed on the upper and lower sides inside the reactor support (1) and the assembly frame (4) is limited by the assembly slot (7).

3. A stacked microchannel reactor for pharmaceutical applications according to claim 2, wherein: The stacking mechanism includes a limiting block (8), which is fixedly installed on the upper and lower sides of the inside of the assembly frame (4). The limiting blocks (8) are symmetrically arranged and each has a slidably inserted positioning slide rod (9). The outer end of the symmetrically arranged positioning slide rod (9) is slidably inserted into the assembly slot (7) inside the stacking locking rod (3) to lock and position the equidistantly distributed assembly frame (4).

4. A stacked microchannel reactor for pharmaceutical applications according to claim 3, wherein: The stacking mechanism includes an unlocking slide plate (10), which is fixedly installed on the inner end of the symmetrically arranged positioning slide rod (9). The inner walls of the upper and lower unlocking slide plates (10) are connected to each other by abutment springs (11), and the outer ends of the symmetrically arranged unlocking slide plates (10) slide through the outside of the mounting frame (4).

5. A stacked pharmaceutical microchannel reactor according to claim 1, characterized in that: The reaction mechanism includes a transmission hose (12), which is symmetrically connected to the temperature control delivery pipe (2). The front end of the symmetrically arranged transmission hose (12) is connected to the temperature control coil (6) inside the reaction frame (5). The reaction frame (5) is detachably installed on the front end of the mounting bracket (4), so as to realize the stacked installation and positioning of the reaction frame (5) inside the reactor support (1).

6. A stacked pharmaceutical microchannel reactor according to claim 5, characterized in that: The reaction mechanism includes a reaction partition (13), and the reaction partition (13) is fixedly installed on the left and right sides inside the assembly frame (4). The reaction partition (13) forms a sealed reaction space for the assembly frame (4). The reaction partition (13) is installed in pairs and is symmetrically distributed about the vertical central axis of the temperature control coil (6).

7. A stacked pharmaceutical microchannel reactor according to claim 6, characterized in that: The reaction mechanism includes a medium transfer pipe (14), and the medium transfer pipe (14) connects the adjacent reaction partitions (13) on the left and right sides, so that the pharmaceutical raw materials are transported to the next reaction mechanism through the medium transfer pipe (14) for reaction operation.

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