A plasma centrifugation post-flow rate detection structure

Abstract

The utility model discloses a plasma centrifugal flow rate detection structure belongs to blood product production technical field. The structure includes centrifuge, flow rate measurement container and buffer bucket, and the liquid inlet of flow rate measurement container is passed through the liquid outlet pipeline and is communicated with the supernatant liquid outlet of centrifuge, and the liquid inlet of buffer bucket is communicated with the liquid outlet of flow rate measurement container through temperature measurement component. The whole supernatant liquid outlet temperature and liquid outlet flow rate detection of centrifuge are all completed in the closed environment, do not need to dismount liquid outlet pipeline or dismount other components, and the operation is simple, avoids the risk that plasma splashes to the ground, avoids the plasma exposure in the external environment simultaneously, and the risk of plasma being contaminated is reduced significantly.

Description

Technical Field

[0001] This utility model relates to a plasma flow rate detection structure after centrifugation, belonging to the field of blood product manufacturing technology. Background Technology

[0002] Currently, after plasma is dissolved in the workshop, four centrifuges are used to separate and extract cryoprecipitate. After the cryoprecipitate and supernatant are separated, a floor-standing buffer tank is used to collect the supernatant flowing out of the centrifuge. When collecting the plasma supernatant, the following conditions must be met: flow rate ≤ 2L / min, temperature 0.5℃~3℃. Figure 1 As shown, when measuring the liquid flow rate of centrifuge 1, the connection between the liquid outlet pipe 2 of centrifuge 1 and the buffer tank 5 needs to be disconnected. Then, the end of the liquid outlet pipe 2 away from centrifuge 1 is inserted into a beaker 6 with a volume of 2L. At the same time, a stopwatch is used to measure the liquid flow rate of centrifuge 1. After the measurement is completed, the liquid outlet pipe 2 is reconnected to the buffer tank 5.

[0003] However, measuring the flow rate of the liquid outlet from centrifuge 1 requires disassembling and installing the liquid outlet pipe 2, which is cumbersome. Furthermore, if the operation is not performed properly, there is a risk of blood plasma spilling onto the ground. In addition, during the measurement process, the blood plasma is exposed to the external environment, which poses a risk of contamination. Utility Model Content

[0004] To solve the above-mentioned technical problems, this utility model provides a plasma flow rate detection structure after centrifugation.

[0005] This utility model is achieved through the following technical solution: A plasma flow rate detection structure after centrifugation includes a centrifuge, a flow rate measuring container, and a buffer tank. The inlet of the flow rate measuring container is connected to the supernatant outlet of the centrifuge via an outlet pipe, and the inlet of the buffer tank is connected to the outlet of the flow rate measuring container via a temperature measuring component.

[0006] The flow rate measuring container includes a container body, with an inlet pipe A at the top and an outlet pipe A at the bottom, and a manual valve installed on the outlet pipe A.

[0007] The container body has a volume of 3L.

[0008] The inlet pipe A is a 90-degree bend.

[0009] The bottom plate of the container body slopes downwards from the centrifuge side to the buffer tank side.

[0010] One end of the liquid outlet pipe A is connected to the lowest point of the container body bottom plate, and the downward tilt angle of the liquid outlet pipe A is consistent with the downward tilt angle of the container body bottom plate.

[0011] The temperature measurement assembly includes a tee and a thermometer mounted on the tee.

[0012] The tee is a T-shaped tee. The inlet of the tee is connected to the end of the outlet pipe A away from the main body of the container. The straight outlet of the tee is connected to the inlet of the buffer tank. An end seal plate is provided at the side outlet of the tee for sealing. A thermometer is installed on the end seal plate, and one end of the thermometer extends into the interior of the tee.

[0013] The beneficial effects of this invention are as follows: the detection of the supernatant outlet temperature and outlet flow rate of the centrifuge is completed in a closed environment without disassembling the outlet pipe or other components. The operation is simple, avoids the risk of plasma spilling onto the ground, and avoids exposing the plasma to the external environment, thus significantly reducing the risk of plasma contamination. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of existing plasma flow rate detection after centrifugation; Figure 2 This is a schematic diagram of the structure of this utility model; Figure 3 This is a schematic diagram of the flow rate measuring container of this utility model; Figure 4 This is a schematic diagram of the temperature measurement component of this utility model.

[0015] In the diagram: 1-Centrifuge, 2-Outlet pipe, 3-Flow rate measuring container, 31-Container body, 32-Inlet pipe A, 33-Manual valve, 34-Outlet pipe A, 4-Temperature measuring component, 41-Tee, 42-Thermometer, 5-Buffer tank. Detailed Implementation

[0016] The technical solution of this utility model is further described below, but the scope of protection is not limited to what is described.

[0017] like Figures 1 to 4As shown, the plasma flow rate detection structure after centrifugation according to this utility model includes a centrifuge 1, a flow rate measuring container 3, and a buffer tank 5. The inlet of the flow rate measuring container 3 is connected to the supernatant outlet of the centrifuge 1 through an outlet pipe 2. The inlet of the buffer tank 5 is connected to the outlet of the flow rate measuring container 3 through a temperature measuring component 4. After the plasma is dissolved, it is separated and the cryoprecipitate is extracted by the centrifuge 1. After the cryoprecipitate and the supernatant are separated, the supernatant flows sequentially through the outlet pipe 2, the flow rate measuring container 3, and the temperature measuring component 4, and then enters the buffer tank 5. During this process, the temperature of the supernatant flowing through it is measured in real time by the temperature measuring component 4. When it is necessary to test the outflow rate of the supernatant from centrifuge 1, first close the inlet of centrifuge 1. After the supernatant in the flow rate measuring container 3 is drained, close the outlet of the flow rate measuring container 3 and open the inlet of centrifuge 1. Simultaneously, start timing. When 2L of supernatant has been collected in the flow rate measuring container 3, stop timing and determine whether the outflow rate of centrifuge 1 is ≤2L / min based on the timing time. The entire process of measuring the supernatant outlet temperature and outflow rate of centrifuge 1 is completed in a closed environment without disassembling the outlet pipe 2 or other components. The operation is simple, avoids the risk of plasma spilling onto the ground, and prevents plasma from being exposed to the external environment, significantly reducing the risk of plasma contamination.

[0018] The flow rate measuring container 3 includes a container body 31, with an inlet pipe A32 at the top and an outlet pipe A34 at the bottom, and a manual valve 33 installed on the outlet pipe A34.

[0019] The volume of the container body 31 is 3L. When detecting the outflow rate of the supernatant from the centrifuge 1, it is necessary to collect 2L of supernatant using the container body 31. However, since the flow rate measuring container 3 is a closed container and there is air inside, the volume of the container body 31 is set to 3L to ensure that it can successfully collect 2L of supernatant.

[0020] The inlet pipe A32 is a 90-degree bend.

[0021] The bottom plate of the container body 31 is inclined downwards from the centrifuge 1 side to the buffer tank 5 side. To facilitate cleaning and prevent liquid accumulation in the container body 31 before and after liquid flow rate detection, the bottom plate of the container body 31 is inclined.

[0022] One end of the liquid outlet pipe A34 is connected to the lowest point of the bottom plate of the container body 31, and the downward tilt angle of the liquid outlet pipe A34 is consistent with the downward tilt angle of the bottom plate of the container body 31.

[0023] The temperature measuring component 4 includes a tee 41 and a thermometer 42 mounted on the tee 41.

[0024] The tee 41 is a T-shaped tee. The inlet of the tee 41 is connected to the end of the outlet pipe A34 away from the container body 31, and the straight outlet of the tee 41 is connected to the inlet of the buffer tank 5. An end seal plate is provided at the side outlet of the tee 41 for sealing. A thermometer 42 is installed on the end seal plate, and one end of the thermometer 42 extends into the interior of the tee 41. To improve the reliability of the temperature detection results of the plasma supernatant, one end of the thermometer 42 is extended into the interior of the tee 41 to directly contact the plasma supernatant for temperature detection.

[0025] Specifically, the inlet pipe A32 and the end of the outlet pipe 2 away from the centrifuge 1, the outlet pipe A34 and the inlet of the tee 41, and the straight outlet of the tee 41 and the inlet of the buffer tank 5 are all connected and sealed by quick-release clamps.

[0026] The working principle of the plasma flow rate detection structure after centrifugation described in this utility model is as follows: After the plasma is thawed, the cryoprecipitate is separated and extracted by centrifuge 1. After the cryoprecipitate and the supernatant are separated, the supernatant flows sequentially through the outlet pipe 2, the flow rate measuring container 3 and the temperature measuring component 4, and then enters the buffer tank 5. During this process, the temperature of the supernatant flowing through its three-way valve 41 is measured in real time by thermometer 42.

[0027] When it is necessary to test the outflow rate of the supernatant from centrifuge 1, first close the inlet of centrifuge 1. After the supernatant in the flow rate measuring container 3 is drained, close the manual valve 33, open the inlet of centrifuge 1, and start timing simultaneously. When 2L of supernatant has been collected in the container body 31, stop timing and determine whether the outflow rate of centrifuge 1 is ≤2L / min based on the timing time. The entire process of measuring the supernatant outflow temperature and outflow rate of centrifuge 1 is completed in a closed environment without disassembling the outflow pipe 2 or other components. The operation is simple, avoids the risk of plasma spilling onto the ground, and prevents plasma from being exposed to the external environment, significantly reducing the risk of plasma contamination.

[0028] After completing the liquid flow rate test, open the manual valve 33 to discharge the supernatant in the container body 31 into the buffer tank 5.

Claims

1. A plasma flow rate detection structure after centrifugation, characterized in that: It includes a centrifuge (1), a flow rate measuring container (3) and a buffer tank (5). The inlet of the flow rate measuring container (3) is connected to the supernatant outlet of the centrifuge (1) through the outlet pipe (2). The inlet of the buffer tank (5) is connected to the outlet of the flow rate measuring container (3) through the temperature measuring component (4).

2. The plasma flow rate detection structure as described in claim 1, characterized in that: The flow rate measuring container (3) includes a container body (31), with an inlet pipe A (32) at the top and an outlet pipe A (34) at the bottom, and a manual valve (33) installed on the outlet pipe A (34).

3. The plasma flow rate detection structure after centrifugation as described in claim 2, characterized in that: The volume of the container body (31) is 3L.

4. The plasma flow rate detection structure after centrifugation as described in claim 2, characterized in that: The inlet pipe A (32) is a 90-degree bend.

5. The plasma flow rate detection structure after centrifugation as described in claim 2, characterized in that: The bottom plate of the container body (31) slopes downward from the centrifuge (1) side to the buffer tank (5) side.

6. The plasma flow rate detection structure after centrifugation as described in claim 5, characterized in that: One end of the liquid outlet pipe A (34) is connected to the lowest point of the bottom plate of the container body (31), and the downward tilt angle of the liquid outlet pipe A (34) is consistent with the downward tilt angle of the bottom plate of the container body (31).

7. The plasma flow rate detection structure as described in claim 2, characterized in that: The temperature measuring assembly (4) includes a tee (41) and a thermometer (42) mounted on the tee (41).

8. The plasma flow rate detection structure after centrifugation as described in claim 7, characterized in that: The tee (41) is a T-shaped tee. The inlet of the tee (41) is connected to the end of the outlet pipe A (34) away from the container body (31). The straight outlet of the tee (41) is connected to the inlet of the buffer tank (5). An end sealing plate is provided at the side outlet of the tee (41) for sealing. The thermometer (42) is installed on the end sealing plate, and one end of the thermometer (42) extends into the interior of the tee (41).

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