Contact imaging device

Abstract

The present disclosure provides a contact imaging device, which comprises a controller, an imaging body, a cover and an adjustable light source module; the adjustable light source module is arranged inside the cover, and the adjustable light source module and the imaging module are both in communication connection with the controller; when the cover is arranged on the imaging body to form a darkroom state, the controller is used to send different driving instructions to the adjustable light source module at different collection time points to drive the adjustable light source module to respectively emit light signals of matching colors; the imaging module is used to respectively collect intermediate images of the biological sample film under the light signals at each collection time point to output the corresponding color images of the biological sample film. The device of the present disclosure can automatically and efficiently complete the color imaging of the biological sample film, so as to facilitate more comprehensive and accurate analysis of the biological sample film, and meet the imaging scene with higher demand.

Description

[0001] This disclosure claims priority to Chinese Patent Application No. 2024224012601, filed on September 29, 2024. The entire contents of the aforementioned Chinese Patent Application are incorporated herein by reference. Technical Field

[0002] This disclosure relates to the field of biological imaging technology, and in particular to a contact imaging device. Background Technology

[0003] Currently, black-and-white imaging techniques are commonly used to obtain images of biological sample membranes; however, the imaging results of black-and-white images often cannot meet the needs of more demanding imaging analysis scenarios. Summary of the Invention

[0004] The technical problem to be solved by this disclosure is to overcome the above-mentioned defects in the prior art, and the purpose is to provide a contact imaging device.

[0005] This disclosure solves the above-mentioned technical problems through the following technical solution:

[0006] This disclosure provides a contact imaging device, which includes a controller, an imaging body, a cover, and an adjustable light source module;

[0007] The imaging subject includes a main structure and an imaging module disposed on the main structure. The imaging module is used to place a biological sample membrane. The adjustable light source module is disposed inside the cover body, and both the adjustable light source module and the imaging module are communicatively connected to the controller.

[0008] When the cover is placed on the imaging body to form a darkroom, the controller is used to send different driving commands to the adjustable light source module at different acquisition times to drive the adjustable light source module to emit light signals of matching colors respectively.

[0009] The imaging module is used to acquire intermediate images of the biological sample membrane under the light signal at each acquisition time, so as to output a color image corresponding to the biological sample membrane.

[0010] Preferably, the adjustable light source module and the controller are connected via several communication cables;

[0011] Different communication cables are driven by different driving commands to drive the adjustable light source module to emit light signals of different colors.

[0012] Preferably, the adjustable light source module includes a light-emitting auxiliary component and a light-emitting component;

[0013] The light-emitting component is a backlight that can emit light of different colors;

[0014] The light-emitting components are arranged in a preset distribution pattern within the recessed structure inside the cover body, and the light-emitting auxiliary components are arranged on the cover body and cover the light-emitting components within the recessed structure.

[0015] Preferably and / or, the light-emitting component includes a plurality of LED beads and / or a light-emitting screen.

[0016] Preferably, the placement of the light-emitting component is matched to the preset placement position of the biological sample membrane.

[0017] Preferably, when the light-emitting component includes a plurality of LED beads, the plurality of LED beads are evenly distributed within the structural area of ​​the recessed structure, and the structural area is configured to correspond to the imaging of the imaging module.

[0018] Preferably, different biological sample membranes correspond to different light acquisition sequences, and different light acquisition sequences correspond to different combinations of light colors;

[0019] And / or,

[0020] The imaging module is used to detect the signal projected after the light signal emitted by the adjustable light source module illuminates the biological sample membrane, so as to obtain the intermediate image corresponding to the acquisition time.

[0021] Preferably, the controller is disposed within the main structure, and the imaging body further includes a touch screen disposed on the main structure and communicatively connected to the controller;

[0022] And / or,

[0023] The imaging body is also provided with an external port, which includes an interface for connecting to a mouse and / or keyboard.

[0024] Preferably, the imaging subject further includes a memory disposed within the subject structure, the memory being used to store the intermediate image and / or the color image;

[0025] The main structure is also provided with a data transmission port, which is used to transmit the intermediate image and / or the color image to the outside.

[0026] And / or,

[0027] The imaging body also includes a power module disposed within the main structure, the power module being used to supply power to the contact imaging device.

[0028] Preferably, the imaging body further includes a cooling mechanism disposed within the main body structure and communicatively connected to the controller, the cooling mechanism being used to reduce the internal temperature of the imaging device;

[0029] And / or,

[0030] The imaging subject also includes a wireless communication module disposed within the main structure and communicatively connected to the controller. The wireless communication module is used to communicate wirelessly with external communication devices.

[0031] And / or,

[0032] The main structure is also provided with a power supply interface, which is used to connect to an external power source to supply power to the power module;

[0033] And / or,

[0034] The power module includes a wireless power supply module, which is used to wirelessly connect to an external power source to wirelessly supply power to the power module.

[0035] Based on common knowledge in the field, the preferred conditions described can be combined arbitrarily to obtain the preferred embodiments of this disclosure.

[0036] The positive and progressive effects of this disclosure are as follows:

[0037] This disclosure proposes a novel contact imaging device that sequentially emits light signals of different colors by driving an adjustable light source module multiple times to obtain images of a biological sample membrane under each monochromatic light signal. By calibrating and fusing these images, a final color image of the biological sample membrane is obtained. This enables automatic and efficient color imaging of biological sample membranes, allowing for a more accurate, clear, and comprehensive representation of the characteristics and state of the biological sample membrane, facilitating more precise analysis. This solves the problem that existing Mark imaging can only be black and white, which cannot meet the requirements of practical imaging scenarios, thus satisfying higher-demand imaging scenarios. Attached Figure Description

[0038] Figure 1 This is a schematic diagram of the module of the contact imaging device according to Embodiment 1 of this disclosure.

[0039] Figure 2 This is a schematic diagram of the contact imaging device of Embodiment 1 of this disclosure in the open state.

[0040] Figure 3 This is a schematic diagram of the contact imaging device of Embodiment 1 of this disclosure in a closed state.

[0041] Figure 4This is a schematic diagram of an existing black and white imaging system.

[0042] Figure 5 This is a schematic diagram of the color image output by the contact imaging device according to Embodiment 1 of this disclosure.

[0043] Figure 6 This is a schematic diagram of the contact imaging device according to Embodiment 2 of this disclosure.

[0044] Figure 7 This is a first structural schematic diagram of a contact imaging device with a display screen according to Embodiment 2 of this disclosure.

[0045] Figure 8 This is a second structural schematic diagram of a contact imaging device with a display screen according to Embodiment 2 of this disclosure. Detailed Implementation

[0046] The present disclosure is further illustrated below by way of embodiments, but the present disclosure is not limited to the scope of the embodiments described herein.

[0047] Example 1

[0048] like Figure 1 As shown, the contact imaging device of this embodiment includes a controller 1, an imaging body 2, a cover 3, and an adjustable light source module 4; the adjustable light source module 4 can emit light of different colors, including red, green, blue, yellow, white, etc.

[0049] The imaging body 2 includes a main structure 5 and an imaging module 6 disposed on the main structure 5. The imaging module 6 is used to place a biological sample membrane. The adjustable light source module 4 is disposed inside the cover 3, and both the adjustable light source module 4 and the imaging module 6 are communicatively connected to the controller 1.

[0050] The cover 3 can be connected to the imaging body 2 via hinges or other means, or it can be integrally formed with the imaging body 2. For example... Figure 2 As shown, when placing the biological sample membrane, open the cover 3 to allow for placement of the biological sample membrane; as... Figure 3 As shown, after placing the biological sample membrane and preparing for imaging, the cover 3 is placed on the imaging body 2 to create a darkroom environment, preventing interference and ensuring imaging quality. Specifically, the cover 3 can be opened or closed manually, or a power mechanism can be integrated into the cover 3 and / or the imaging body 2. This power mechanism is communicatively connected to the controller 1 to automatically drive the cover 3 to open or close, improving the intelligence of the entire imaging process and enhancing the convenience and flexibility of operation.

[0051] With the cover 3 covering the imaging body 2 to form a darkroom, the controller 1 is used to send different driving commands to the adjustable light source module 4 at different acquisition times to drive the adjustable light source module 4 to emit light signals of matching colors respectively.

[0052] Imaging module 6 is used to acquire intermediate images of the biological sample membrane under the light signal at each acquisition time, so as to output the corresponding color image of the biological sample membrane.

[0053] For example, at the first acquisition time, a drive command to emit blue light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding blue light; at the second acquisition time, a drive command to emit red light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding red light; similarly, at the third acquisition time, a drive command to emit yellow light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding yellow light; at the fourth acquisition time, a drive command to emit green light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding green light... and so on, so it will not be described in detail here.

[0054] Imaging module 6 is used to acquire images of the biological sample membrane under different light signals at these acquisition times, calibrate several of these images, and then fuse the calibrated images to obtain the final color image of the biological sample membrane.

[0055] In particular, the images of biological sample membranes at different acquisition times will be stored in a timely manner for subsequent summarization and processing.

[0056] Specifically, such as Figure 4 As shown, in existing technologies, the images acquired using the bonding imaging technique are all black and white, but such imaging results cannot meet the higher requirements of imaging analysis; while in this disclosure, as Figure 5 As shown, this invention solves the problem that existing Mark imaging can only be black and white, which cannot meet the requirements of actual imaging scenarios. It enables color imaging of biological sample membranes, which can more accurately, clearly and comprehensively reflect the characteristics and state of biological sample membranes, facilitate better analysis, and meet higher imaging analysis requirements.

[0057] The contact imaging device of this embodiment can be applied in many fields, including but not limited to protein detection, nucleic acid detection, isotope detection, cell detection, tissue detection and other detection scenarios.

[0058] This solution proposes a novel contact imaging device. By repeatedly driving the adjustable light source module 4 to emit light signals of different colors, images of the biological sample membrane are obtained under each monochromatic light signal. After calibrating and fusing these images, the final color image of the biological sample membrane is obtained. This enables automatic and efficient color imaging of the biological sample membrane, allowing for a more accurate, clear, and comprehensive representation of the characteristics and state of the biological sample membrane. This facilitates more precise analysis of the biological sample membrane and solves the problem that existing Mark imaging can only be black and white, which cannot meet the requirements of actual imaging scenarios. This solution meets the higher requirements of imaging scenarios.

[0059] Example 2

[0060] The contact imaging device in this embodiment is a further improvement on Embodiment 1, specifically:

[0061] In a feasible solution, such as Figure 6 As shown, the adjustable light source module 4 and the controller 1 are connected via several communication cables 7.

[0062] Different communication cables 7 are driven by different commands to drive the adjustable light source module 4 to emit light signals of different colors. The controller 1 is integrated into the imaging body 2 or the cover 3, preferably into the imaging body 2. When the controller 1 is located in the imaging body 2, the two ends of the different communication cables 7 are respectively connected to the adjustable light source module 4 and the controller 1, and are concealed between the imaging body 2 and the cover 3.

[0063] In this scheme, multiple channels are formed based on different communication cables 7 to complete the separate transmission of different commands, so as to complete the independent control of different color light signals, realize the support of multi-channel imaging technology, and ensure the feasibility, flexibility and accuracy of color imaging in contact imaging devices.

[0064] In a feasible solution, such as Figure 6 As shown, the adjustable light source module 4 includes a light-emitting auxiliary component 8 and a light-emitting component 9;

[0065] Among them, the light-emitting component 9 is a backlight that can emit light of different colors;

[0066] The light-emitting component 9 is arranged in a preset distribution pattern in the recessed structure inside the cover 3, and the light-emitting auxiliary component 8 is arranged on the cover 3 and covers the light-emitting component 9 in the recessed structure.

[0067] Specifically, the preset distribution method can be any method that can be deployed according to actual deployment needs, as long as the imaging requirements can be met.

[0068] In this scheme, the light-emitting auxiliary component 8 is a light guide plate, a light-diffusing plate, etc. The light-emitting auxiliary component 8 is used to assist in uniformly processing the light signal after the backlight emits a light signal, so as to ensure the imaging quality under each monochromatic light signal, thereby improving the quality of the final color imaging.

[0069] In addition, the light-emitting component 9 is located in a recessed structure inside the cover 3. This structural design makes reasonable use of space, avoids unnecessary waste of space, and ensures the rationality of the spatial dimensions of the entire device.

[0070] In one feasible embodiment, the light-emitting component 9 includes several LED beads, a light-emitting screen, etc. The LED beads can be LED beads, and the light-emitting screen can be an OLED (an OLED-type organic light-emitting device).

[0071] In this solution, the light-emitting component 9 can be any type of light-emitting device, as long as it can meet the corresponding light-emitting requirements.

[0072] In one feasible solution, the placement of the light-emitting component 9 is matched to the preset placement position of the biological sample membrane.

[0073] In this solution, the arrangement of LED beads and OLED light-emitting screen can be matched and set according to the preset placement position of the biological sample membrane. For example, if the preset placement position is in the center, the LED beads can be arranged around the center position, and a small number of LED beads can be set in other positions, or even no LED beads can be set, thereby reducing unnecessary cost investment while ensuring imaging quality.

[0074] In one feasible solution, when the light-emitting component 9 includes a plurality of LEDs, the plurality of LEDs are evenly distributed within the structural area of ​​the recessed structure, and the structural area is configured to correspond to the imaging of the imaging module 6.

[0075] In this design, all LED beads are evenly distributed within the recessed structure on the inner side of the cover 3, ensuring that the imaging effect can meet the requirements regardless of where the biological sample membrane is placed in the imaging area.

[0076] In a feasible scheme, different biological sample membranes correspond to different light acquisition sequences, and different light acquisition sequences correspond to different combinations of light colors.

[0077] In this scheme, when imaging different biological sample membranes, the illumination sequence (i.e., the driving order of different colors of light) that matches the type of biological sample membrane can be used to illuminate it sequentially, thereby further ensuring the imaging quality of each type of biological sample membrane.

[0078] The optical signal sequence corresponding to each type of biological sample membrane can be determined in advance based on experiments, and can also be readjusted according to actual needs.

[0079] In one feasible scheme, the imaging module 6 is used to detect the signal projected after the light signal emitted by the adjustable light source module 4 illuminates the biological sample membrane, so as to obtain an intermediate image at the corresponding acquisition time.

[0080] In this scheme, the imaging module 6 includes a CMOS (complementary metal-oxide-semiconductor) detector, a CCD (charge-coupled device) detector, etc., to realize imaging processing of the biological sample membrane attached to the imaging module 6, so as to obtain the image under the corresponding monochromatic light, thus ensuring the reliability of the imaging processing of the biological sample membrane.

[0081] In addition, the cameras or detectors used in existing traditional imaging methods are all based on the principle of reflection imaging, while the detectors in this embodiment are all projection type. That is, different colors of light are hit on the sample in sequence and projected directly onto the detector to obtain the image of the biological sample membrane under each monochromatic light. Then, these images under monochromatic light are calibrated and fused to form a color image.

[0082] In a feasible solution, such as Figure 6 As shown, the controller 1 is located inside the main structure 5, and the imaging body 2 also includes a touch screen 10 located on the main structure 5 and communicated with the controller 1.

[0083] In this plan, such as Figure 2 As shown, the contact imaging device may not have a touch screen 10, such as... Figure 7 As shown, the contact imaging device can also be integrated with a touch screen 10 to facilitate interaction between the operator and the device, thereby meeting higher usage requirements and further enhancing the overall intelligence of the device.

[0084] In a feasible solution, such as Figure 6 and 8 As shown, the imaging body 2 is also equipped with an external port 11, which includes an interface for connecting to a mouse and / or keyboard. Other types of interfaces, such as a network cable port, can also be provided.

[0085] In this solution, by setting up mouse and keyboard connection ports, it is convenient for staff to use mouse and keyboard to debug, transmit data, or adjust the imaging parameters of the contact imaging device.

[0086] In addition, the contact imaging device is equipped with a touch screen 10, external interfaces for mouse and keyboard, etc., which gives users more options for operation. They can choose the appropriate operation method according to the operating environment or operating habits, thus improving the user experience.

[0087] In one feasible embodiment, the imaging body 2 further includes a memory 12 disposed within the body structure 5, the memory 12 being used to store intermediate images and / or color images;

[0088] The main structure 5 is also equipped with a data transmission port, which is used to transmit intermediate images and / or color images to the outside.

[0089] In this solution, the real-time images under monochromatic light and the fused color images are stored in the memory 12 for subsequent processing. In addition, some data stored in the memory 12 can be accessed through the data transmission port and transmitted to external devices for further viewing, processing and analysis.

[0090] In one feasible embodiment, the imaging body 2 also includes a power module 13 disposed within the main body structure 5, the power module 13 being used to power the contact imaging device.

[0091] In this solution, the contact imaging device has a built-in power module 13 to ensure the battery life of the entire device and to ensure the portability of the contact imaging device.

[0092] In one feasible embodiment, the imaging body 2 also includes a cooling mechanism 14 disposed within the main body structure 5 and communicatively connected to the controller 1. The cooling mechanism 14 is used to reduce the internal temperature of the imaging device.

[0093] The cooling mechanism 14 can be a fan, a semiconductor cooler, etc.

[0094] In this scheme, the cooling mechanism 14 is used to reduce the internal temperature of the contact imaging device. By setting the cooling mechanism 14, the internal temperature of the contact imaging device can be cooled, avoiding overheating of the imaging device and affecting the stability of the imaging, thereby obtaining a better imaging image.

[0095] In one feasible embodiment, the imaging body 2 further includes a wireless communication module 15 disposed within the main body structure 5 and communicatively connected to the controller 1. The wireless communication module 15 is used to communicate wirelessly with external communication devices.

[0096] The wireless communication module 15 includes a Bluetooth module, etc.

[0097] In this solution, the contact imaging device integrates a wireless communication module 15, which can more conveniently realize data interaction with external communication devices, further improving the intelligence and flexibility of the entire device.

[0098] In one feasible solution, the main structure 5 is also provided with a power supply interface, which is used to connect to an external power source to supply power to the power module 13.

[0099] In this solution, the contact imaging device can be powered by an external power supply to the power module 13 via a wired connection based on the power supply interface.

[0100] In one feasible embodiment, the power module 13 includes a wireless power supply module for wirelessly connecting to an external power source to wirelessly power the power module 13.

[0101] In this solution, the contact imaging device can use a wireless power supply module, which enables the external power supply module 13 to be powered wirelessly, achieving a more convenient power supply effect.

[0102] In addition, in this embodiment, the adjustable light source module 4 is powered and the backlight is controlled to emit different colors of light under different commands through hardware PCBA (printed circuit board). When the Mark strip corresponding to the biological sample membrane is collected, the backlight lights up with the corresponding color of light. The light passes through the biological sample membrane, and the imaging module 6 collects the light to form the corresponding image. Similarly, after multiple illuminations and collections with different colors of light, all images corresponding to the biological sample membrane under different monochromatic light are collected. These images are calibrated and fused to finally obtain the color image corresponding to the biological sample membrane.

[0103] To make the objectives, technical solutions, and advantages of the embodiments of this disclosure clearer, the technical solutions of the embodiments of this disclosure will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this disclosure, and not all embodiments. Based on the embodiments of this disclosure, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this disclosure.

Claims

1. A contact imaging device, characterized in that, The contact imaging device includes a controller, an imaging body, a cover, and an adjustable light source module; The imaging subject includes a main structure and an imaging module disposed on the main structure. The imaging module is used to place a biological sample membrane. The adjustable light source module is disposed inside the cover body, and both the adjustable light source module and the imaging module are communicatively connected to the controller. When the cover is placed on the imaging body to form a darkroom, the controller is used to send different driving commands to the adjustable light source module at different acquisition times to drive the adjustable light source module to emit light signals of matching colors respectively. The imaging module is used to acquire intermediate images of the biological sample membrane under the light signal at each acquisition time, so as to output a color image corresponding to the biological sample membrane.

2. The contact imaging device as described in claim 1, characterized in that, The adjustable light source module and the controller are connected via several communication cables; Different communication cables are driven by different driving commands to drive the adjustable light source module to emit light signals of different colors.

3. The contact imaging device as described in claim 2, characterized in that, The adjustable light source module includes a light-emitting auxiliary component and a light-emitting component; The light-emitting component is a backlight that can emit light of different colors; The light-emitting components are arranged in a preset distribution pattern within the recessed structure inside the cover body, and the light-emitting auxiliary components are arranged on the cover body and cover the light-emitting components within the recessed structure.

4. The contact imaging device as described in claim 3, characterized in that, The light-emitting auxiliary component includes a light guide plate and / or a light-diffusing plate; And / or, the light-emitting component includes a plurality of LED beads and / or a light-emitting screen.

5. The contact imaging device as described in claim 3, characterized in that, The placement of the light-emitting components is matched to the preset placement position of the biological sample membrane.

6. The contact imaging device as described in claim 3, characterized in that, When the light-emitting component includes a plurality of LED beads, the plurality of LED beads are evenly distributed within the structural area of ​​the recessed structure, and the structural area is configured to correspond to the imaging of the imaging module.

7. The contact imaging device as described in any one of claims 1-6, characterized in that, Different biological sample membranes correspond to different light acquisition sequences, and different light acquisition sequences correspond to different combinations of light colors; And / or, The imaging module is used to detect the signal projected after the light signal emitted by the adjustable light source module illuminates the biological sample membrane, so as to obtain the intermediate image corresponding to the acquisition time.

8. The contact imaging device as described in any one of claims 1-6, characterized in that, The controller is disposed within the main structure, and the imaging body also includes a touch screen display that is communicatively connected to the controller and disposed on the main structure; And / or, The imaging body is also provided with an external port, which includes an interface for connecting to a mouse and / or keyboard.

9. The contact imaging device as described in claim 8, characterized in that, The imaging subject also includes a memory disposed within the subject structure, the memory being used to store the intermediate image and / or the color image; The main structure is also provided with a data transmission port, which is used to transmit the intermediate image and / or the color image to the outside. And / or, The imaging body also includes a power module disposed within the main structure, the power module being used to supply power to the contact imaging device.

10. The contact imaging device as claimed in claim 9, characterized in that, The imaging main body also includes a cooling mechanism disposed within the main body structure and communicatively connected to the controller, the cooling mechanism being used to reduce the internal temperature of the imaging device; And / or, The imaging subject also includes a wireless communication module disposed within the main structure and communicatively connected to the controller. The wireless communication module is used to communicate wirelessly with external communication devices. And / or, The main structure is also provided with a power supply interface, which is used to connect to an external power source to supply power to the power module; And / or, The power module includes a wireless power supply module, which is used to wirelessly connect to an external power source to wirelessly supply power to the power module.

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