7-ketolithocholic acid low-temperature vacuum concentration apparatus

Abstract

This utility model relates to the field of 7-ketolithocholic acid technology, and more particularly to a low-temperature vacuum concentration device for 7-ketolithocholic acid. It includes a main body of the low-temperature vacuum concentration device and a filter tube. Flanges are provided at both ends of the filter tube. The outlet end of the main body of the low-temperature vacuum concentration device is connected to the filter tube via flanges. Two mounting components are installed inside the filter tube, and both sides of the two mounting components are connected by connecting rods. A titanium alloy sintered filter element and a polytetrafluoroethylene (PTFE) pleated membrane filter element are respectively installed in the two mounting components, with the titanium alloy sintered filter element positioned above the PTFE pleated membrane filter element. In this utility model, by adding a filter tube at the outlet end of the main body of the 7-ketolithocholic acid low-temperature vacuum concentration device, impurities in the 7-ketolithocholic acid solution after concentration are trapped by the titanium alloy sintered filter element and the PTFE pleated membrane filter element, thereby improving the purity of the 7-ketolithocholic acid solution.

Description

Technical Field

[0001] This utility model relates to the field of 7-ketolithocholic acid technology, and in particular to a low-temperature vacuum concentration device for 7-ketolithocholic acid. Background Technology

[0002] 7-Ketolithocholic acid is a core intermediate in the synthesis of key drugs such as ursodeoxycholic acid and obeticholic acid. Taking the synthesis of ursodeoxycholic acid as an example, it is widely used in clinical practice to treat gallstones and chronic liver diseases, and the global market demand continues to grow.

[0003] In the synthesis of 7-ketolithocholic acid, the concentration process is one of the key steps. The concentration process requires precise control of parameters such as temperature and pressure to avoid decomposition of the target product or side reactions. Traditional low-temperature vacuum concentration equipment directly discharges the solution after concentration. The 7-ketolithocholic acid solution may carry large particulate impurities. Direct discharge will reduce the purity of the 7-ketolithocholic acid solution. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a low-temperature vacuum concentration device for 7-ketolithocholic acid.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A 7-ketolithocholic acid low-temperature vacuum concentration device includes a low-temperature vacuum concentration device body and a filter tube. Both ends of the filter tube are provided with flanges. The outlet end of the low-temperature vacuum concentration device body is connected to the filter tube through the flanges. Two mounting components are provided inside the filter tube. Both sides of the two mounting components are connected by connecting rods. A titanium alloy sintered filter element and a polytetrafluoroethylene pleated membrane filter element are respectively installed in the two mounting components. The titanium alloy sintered filter element is located above the polytetrafluoroethylene pleated membrane filter element.

[0007] The installation assembly includes a bottom ring, a support mesh, and a pressure ring. The support mesh is fixedly installed inside the bottom ring, and the bottom ring is fixedly connected to the connecting rod. The bottom surfaces of the titanium alloy sintered filter element and the polytetrafluoroethylene pleated membrane filter element are respectively in contact with the top surfaces of the support mesh in the two installation assemblies.

[0008] In addition, a preferred structure is that slots are provided on both sides of the inner wall of the filter tube.

[0009] In addition, a preferred structure is that the two connecting rods are respectively inserted into the slots, the inner side of the connecting rods is provided with two sliding grooves, and the inner side of the top of the connecting rods is provided with a pull block.

[0010] In addition, the preferred structure is that threaded holes are provided at both ends of the top surface of the bottom ring, and an annular groove is provided at the upper end of the bottom ring, with the bottom surface of the annular groove being flush with the top surface of the support mesh.

[0011] In addition, a preferred structure is that sliders are provided on both sides of the outer wall of the pressure ring, and the sliders slide within the groove.

[0012] In addition, a preferred structure is that both ends of the top surface of the pressure ring are provided with through holes, and a bolt passes through the through holes and is then threaded into the threaded hole.

[0013] Furthermore, in a preferred configuration, an annular groove 2 is provided at the lower end of the pressure ring.

[0014] The beneficial effects of this utility model are as follows:

[0015] In this invention, by adding a filter tube to the outlet end of the 7-ketolithocholic acid low-temperature vacuum concentration equipment, impurities in the 7-ketolithocholic acid solution after concentration will be retained by the titanium alloy sintered filter element and the polytetrafluoroethylene pleated membrane filter element, thereby improving the purity of the 7-ketolithocholic acid solution. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of the low-temperature vacuum concentration device for 7-ketolithocholic acid proposed in this utility model.

[0017] Figure 2 This is a schematic diagram of the filter tube and installation components of the low-temperature vacuum concentration device for 7-ketolithocholic acid proposed in this utility model.

[0018] Figure 3 A schematic diagram of the installation components of the low-temperature vacuum concentration equipment for 7-ketolithocholic acid proposed in this utility model when installing the filter element.

[0019] Figure 4 This is a schematic diagram of the bottom ring and connecting rod structure of the low-temperature vacuum concentration device for 7-ketolithocholic acid proposed in this utility model.

[0020] Figure 5 The low-temperature vacuum concentration device for 7-ketolithocholic acid proposed in this utility model Figure 4 Enlarged structural diagram at point A in the middle;

[0021] Figure 6 This is an exploded structural diagram of the installation components of the 7-ketolithocholic acid low-temperature vacuum concentration equipment proposed in this utility model.

[0022] Figure 7 This is a schematic diagram of the cross-sectional structure of the installation components of the low-temperature vacuum concentration equipment for 7-ketolithocholic acid proposed in this utility model.

[0023] Figure 8 This is a schematic diagram of the pressure ring structure of the 7-ketolithocholic acid low-temperature vacuum concentration device proposed in this utility model.

[0024] In the diagram: 1. Low-temperature vacuum concentration equipment body; 2. Filter tube; 21. Flange; 22. Slot; 3. Connecting rod; 31. Pull block; 32. Slide groove; 4. Mounting assembly; 41. Bottom ring; 411. Threaded hole; 412. Annular groove one; 42. Support mesh; 43. Pressure ring; 431. Slider; 432. Through hole; 433. Annular groove two; 5. Titanium alloy sintered filter element; 6. Polytetrafluoroethylene pleated membrane filter element; 7. Bolt. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0026] Reference Figure 1-8 The 7-ketocholic acid low-temperature vacuum concentration equipment includes a low-temperature vacuum concentration equipment body 1 and a filter tube 2. Both ends of the filter tube 2 are provided with flanges 21. The outlet end of the low-temperature vacuum concentration equipment body 1 is connected to the filter tube 2 through the flanges 21. Two mounting components 4 are provided inside the filter tube 2. Both sides of the two mounting components 4 are connected by connecting rods 3. Titanium alloy sintered filter element 5 and polytetrafluoroethylene pleated membrane filter element 6 are respectively installed in the two mounting components 4. The titanium alloy sintered filter element 5 is located above the polytetrafluoroethylene pleated membrane filter element 6.

[0027] The installation component 4 includes a bottom ring 41, a support net 42, and a pressure ring 43. The support net 42 is fixedly installed inside the bottom ring 41. The bottom ring 41 is fixedly connected to the connecting rod 3. The bottom surfaces of the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6 are in contact with the top surfaces of the support nets 42 in the two installation components 4, respectively.

[0028] Meanwhile, slots 22 are provided on both sides of the inner wall of the filter tube 2.

[0029] Furthermore, the two connecting rods 3 are respectively inserted into the slots 22. Two sliding grooves 32 are provided on the inner side of the connecting rods 3. A pull block 31 is provided on the inner side of the top of the connecting rods 3. By pulling the pull block 31, the connecting rods 3 can be removed from the slots 22, and the installation component 4 can be removed.

[0030] Meanwhile, threaded holes 411 are provided at both ends of the top surface of the bottom ring 41, and an annular groove 412 is provided at the upper end of the bottom ring 41. The bottom surface of the annular groove 412 is flush with the top surface of the support net 42, which facilitates the placement of the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6 onto the support net 42. The support net 42 provides support for the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6.

[0031] Furthermore, sliders 431 are provided on both sides of the outer wall of the pressure ring 43. The sliders 431 slide within the groove 32, making the movement of the pressure ring 43 more stable and limiting the movement of the pressure ring 43.

[0032] Meanwhile, through holes 432 are provided at both ends of the top surface of the pressure ring 43. After the bolt 7 passes through the through hole 432, it is threaded into the threaded hole 411, so that the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6 are pressed between the pressure ring 43 and the bottom ring 41.

[0033] Furthermore, an annular groove 433 is provided at the lower end of the pressure ring 43. The annular groove 433 and the annular groove 412 form an installation space. The edges of the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6 are located in the annular groove 433 and the annular groove 412 and are pressed by the pressure ring 43 and the bottom ring 41.

[0034] In this embodiment, after the concentration of the 7-ketolithocholic acid solution in the main body 1 of the low-temperature vacuum concentration equipment is completed, it is discharged through the outlet and then enters the filter tube 2. The 7-ketolithocholic acid solution will then pass through the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6 in sequence and then enter the preset storage container. The impurities in the 7-ketolithocholic acid solution will be intercepted by the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6, thereby improving the purity of the 7-ketolithocholic acid solution.

[0035] The filter tube 2 needs to be removed periodically for cleaning or replacement of the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6. First, remove the filter tube 2 from the outlet end of the main body 1 of the low-temperature vacuum concentration equipment. Then, pull the pull block 31 to remove the two mounting components 4 from the filter tube 2. Next, unscrew the bolt 7 from the threaded hole 411. At this point, the bottom ring 41 and the pressure ring 43 are loose. Then, pull the pressure ring 43 upwards and remove the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6. If cleaning is required, clean the titanium alloy sintered filter element 5. The PTFE pleated membrane filter element 6 can be cleaned. If replacement is needed, replace with a new one. After cleaning, place the new titanium alloy sintered filter element 5 and PTFE pleated membrane filter element 6 onto the support mesh 42 on the two mounting components 4 respectively. Then, tighten the bolt 7 to insert the threaded bolt 7 into the threaded hole 411. At this time, the titanium alloy sintered filter element 5 and PTFE pleated membrane filter element 6 are pressed between the bottom ring 41 and the pressure ring 43. Then, align the connecting rod 3 with the slot 22 and insert it. Finally, install the filter tube 2 flange 21 onto the outlet end of the low temperature vacuum concentration equipment body 1.

[0036] In this invention, by adding a filter tube 2 to the outlet end of the main body 1 of the 7-ketolithocholic acid low-temperature vacuum concentration equipment, the impurities in the 7-ketolithocholic acid solution after concentration will be retained by the titanium alloy sintered filter element 5 and the polytetrafluoroethylene pleated membrane filter element 6, thereby improving the purity of the 7-ketolithocholic acid solution.

[0037] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. 7 The low-temperature vacuum concentration equipment for 7-ketolithocholic acid, comprising a low-temperature vacuum concentration equipment main body (1) and a filter tube (2), characterized in that, The filter tube (2) is provided with flanges (21) at both ends. The outlet end of the low temperature vacuum concentration equipment body (1) is connected to the filter tube (2) through flanges (21). Two installation components (4) are provided inside the filter tube (2). The two installation components (4) are connected on both sides by connecting rods (3). Titanium alloy sintered filter element (5) and polytetrafluoroethylene pleated membrane filter element (6) are installed in the two installation components (4) respectively. The titanium alloy sintered filter element (5) is located above the polytetrafluoroethylene pleated membrane filter element (6). The installation assembly (4) includes a bottom ring (41), a support net (42), and a pressure ring (43). The support net (42) is fixedly installed inside the bottom ring (41). The bottom ring (41) is fixedly connected to the connecting rod (3). The bottom surfaces of the titanium alloy sintered filter element (5) and the polytetrafluoroethylene pleated membrane filter element (6) are in contact with the top surfaces of the support net (42) inside the two installation assemblies (4), respectively.

2. The 7-ketolithocholic acid low-temperature vacuum concentration equipment according to claim 1, characterized in that, Slots (22) are provided on both sides of the inner wall of the filter tube (2).

3. The 7-ketolithocholic acid low-temperature vacuum concentration equipment according to claim 1, characterized in that, The two connecting rods (3) are respectively inserted into the slots (22). Two sliding grooves (32) are provided on the inner side of the connecting rods (3), and a pull block (31) is provided on the inner side of the top of the connecting rods (3).

4. The 7-ketolithocholic acid low-temperature vacuum concentration device according to claim 1, characterized in that, The bottom ring (41) has threaded holes (411) at both ends of its top surface. An annular groove (412) is provided at the upper end of the bottom ring (41). The bottom surface of the annular groove (412) is flush with the top surface of the support net (42).

5. The 7-ketolithocholic acid low-temperature vacuum concentration device according to claim 1, characterized in that, The outer walls of the pressure ring (43) are provided with sliders (431) on both sides, and the sliders (431) slide within the groove (32).

6. The 7-ketolithocholic acid low-temperature vacuum concentration apparatus according to claim 1, wherein Both ends of the top surface of the pressure ring (43) are provided with through holes (432), and a bolt (7) is inserted into the threaded hole (411) through the through hole (432).

7. The 7-ketolithocholic acid low-temperature vacuum concentration apparatus according to claim 1, characterized by, The pressure ring (43) has an annular groove (433) at its lower end.

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