A synthetic device for improving radiochemical purity of technetium-99m labeled drugs

Abstract

The utility model relates to the field of nuclear medicine radioactive medicine synthesis, disclose a kind of synthesis device of improving technetium-99m labeled drug radioactivity nuclear purity, including organism, the control box is slidably connected in the organism interior, the control box is provided with connecting assembly in the interior;The connecting assembly includes guide pillar two, the guide pillar two outer wall is slidably connected in control box inner wall, the guide pillar two outer wall is fixedly connected with sliding block, the guide pillar two one end is fixedly connected with button, the guide pillar two outer wall is slidably connected with guide pillar one, the guide pillar one outer wall is provided with spring one, the spring one one end is fixedly connected in the guide pillar one one end.In the utility model, extrude button drives the connecting column of bottom to promote guide pillar and make it descend, let sliding block pass through the buckle of top, unfasten spring will drive whole structure to rebound, sliding block is clamped by buckle, reaches the effect of pressing self-locking, improves the efficiency of maintenance inspection, solves the problem that module maintenance and expansibility are poor and waste liquid treatment lacks graded protection.

Description

Technical Field

[0001] This utility model relates to the field of nuclear medicine radiopharmaceutical synthesis, and in particular to a synthesis apparatus for improving the radionuclear purity of technetium-99m labeled drugs. Background Technology

[0002] In the field of nuclear medicine diagnostics, technetium-99m, with its ideal half-life of 6.02 hours, the ease with which its low-energy gamma rays can be detected by SPECT / CT equipment, and its excellent adaptability to radionuclide labeling, has become the most widely used radionuclide in clinical molecular imaging diagnostics—its labeling agents account for more than 80% of the global use of nuclear medicine imaging agents. It can be used in core scenarios such as tumor screening, cardiovascular assessment, and bone disease diagnosis, and is a key carrier for achieving accurate diagnosis. The purity of radioactive nuclei, as... The core quality indicators of labeled drugs directly determine imaging clarity, diagnostic accuracy, and patient radiation safety—if unlabeled free... The parent radionuclide molybdenum-99 or other radioactive impurities can not only interfere with the signal of the target tissue, but also increase the risk of radiation exposure to non-target organs.

[0003] A search revealed an automated synthesis and purification device for 99mTc-labeled radiopharmaceuticals, disclosed in publication number CN220803275U. This device belongs to the field of nuclear medicine radiopharmaceutical synthesis and includes an injection pump, two one-way nine-way valves, a two-way four-way valve, a product purification solid-phase extraction column, a waste liquid bottle, a product collection bottle, and a heatable labeling reaction assembly. Compared to traditional manual methods, this device enables highly efficient automated synthesis of 99mTc-labeled radiopharmaceuticals. While ensuring the yield rate and repeatability of the synthesized drug, it also reduces occupational exposure and radiation dose for workers. Existing equipment suffers from limitations such as limited temperature control functionality, insufficient precision, poor module maintenance and expandability, and a lack of graded protection for waste liquid treatment. Therefore, this paper proposes a synthesis device to improve the radionuclear purity of technetium-99m-labeled drugs to address these issues. Utility Model Content

[0004] To overcome the above shortcomings, this invention provides a synthesis device for improving the radionuclear purity of technetium-99m labeled drugs, aiming to improve the problems of single temperature control function, insufficient precision, poor module maintenance and expandability, and lack of graded protection for waste liquid treatment in the prior art.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A synthetic apparatus for improving the radionuclear purity of technetium-99m labeled drugs includes a body, a control box slidably connected inside the body, and a connecting component disposed inside the control box;

[0007] The connecting assembly includes a second guide post, the outer wall of which is slidably connected to the inner wall of the control box. A slider is fixedly connected to the outer wall of the second guide post. A button is fixedly connected to one end of the second guide post. A first guide post is slidably connected to the outer wall of the second guide post. A first spring is provided on the outer wall of the first guide post. One end of the first spring is fixedly connected to one end of the first guide post, and the other end of the first spring is fixedly connected to the outer end of the control box. A second spring is provided on the outer wall of the second guide post. One end of the second spring is fixedly connected to one end of the slider, and the other end of the second spring is fixedly connected to one end of the first guide post. A connecting plate is fixedly connected to the outer wall of the first guide post, and a connecting post is fixedly connected to the inner wall of the connecting plate.

[0008] As a further description of the above technical solution:

[0009] The outer wall of the connecting column is slidably connected with a groove. The control box is provided with a guide post three and a spring three. One end of the spring three is fixedly connected to the bottom end of the guide post three, and the other end of the spring three is fixedly connected to the inner end of the control box.

[0010] As a further description of the above technical solution:

[0011] The outer wall of the machine body is fixedly connected to a module compartment, the outer wall of the machine body is provided with a display area, the outer wall of the machine body is rotatably connected to an adjustment knob, the outer wall of the machine body is provided with an operation panel, the outer wall of the control box is fixedly connected to a terminal, the outer wall of the control box is rotatably connected to an adjustment knob, and the outer wall of the machine body is provided with a sample inlet.

[0012] As a further description of the above technical solution:

[0013] The machine body has a base inside, and the outer wall of the base has a valve.

[0014] As a further description of the above technical solution:

[0015] A container is fixedly connected to the top of the base, a flange is fixedly connected to the top of the container, and a top interface is fixedly connected to the top of the flange.

[0016] As a further description of the above technical solution:

[0017] The container has a central tube inside and branch tubes inside.

[0018] This utility model has the following beneficial effects:

[0019] 1. In this utility model, the bottom connecting column is first driven by squeezing the button to push the guide column down, allowing the slider to pass through the top buckle. When the button is released again, the spring will cause the entire structure to rebound, and the slider will be locked by the buckle, achieving the effect of self-locking by pressing. This improves the efficiency of maintenance and inspection, and solves the problems of poor module maintenance and expandability, as well as the lack of graded protection for waste liquid treatment.

[0020] 2. In this utility model, the temperature control and operation functions are integrated through the base, the container provides the reaction chamber, and the central tube and branch tubes realize the efficient transmission of temperature control medium or materials. With the sealing design of the top flange and the material control of the valve, wide-range precise temperature control is achieved, which improves the synthesis efficiency and nuclear purity stability of labeled drugs and solves the problems of product purity fluctuation and radiation leakage risk caused by the single function and insufficient sealing of traditional temperature control equipment. Attached Figure Description

[0021] Figure 1 This is a three-dimensional schematic diagram of a synthesis apparatus for improving the radionuclear purity of technetium-99m labeled drugs according to the present invention.

[0022] Figure 2 This is a schematic diagram of the spring structure of a synthesis device for improving the radionuclear purity of technetium-99m labeled drugs proposed in this utility model;

[0023] Figure 3 This is a schematic diagram of the central tube of a synthesis device for improving the radionuclear purity of technetium-99m labeled drugs, as proposed in this utility model.

[0024] Legend:

[0025] 1. Main body; 2. Module compartment; 3. Display area; 4. Operation panel; 5. Adjustment knob one; 6. Control box; 7. Terminal; 8. Adjustment knob two; 9. Sample inlet; 10. Button; 11. Groove; 12. Guide column one; 13. Spring one; 14. Guide column two; 15. Spring two; 16. Slider; 17. Connecting plate; 18. Connecting column; 19. Guide column three; 20. Spring three; 21. Base; 22. Container; 23. Valve; 24. Top interface; 25. Flange; 26. Central tube; 27. Branch tube. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] Example 1:

[0028] Reference Figure 1 and Figure 2 One embodiment of this utility model is a synthesis device for improving the radionuclear purity of technetium-99m labeled drugs, comprising a body 1, a control box 6 slidably connected inside the body 1, and a connection component disposed inside the control box 6;

[0029] The connecting assembly includes a second guide post 14, the outer wall of which is slidably connected to the inner wall of the control box 6. A slider 16 is fixedly connected to the outer wall of the second guide post 14. The trapezoidal shape of the slider 16 allows for one-way locking of the entire assembly. A button 10 is fixedly connected to one end of the second guide post 14. A first guide post 12 is slidably connected to the outer wall of the second guide post 14. A spring 13 is provided on the outer wall of the first guide post 12. The button 10 drives the first guide post 12 to press the spring 13 for locking. One end of the spring 13 is fixedly connected to one end of the first guide post 12, and the other end of the spring 13 is fixedly connected to the outer end of the control box 6. A second spring 15 is provided on the outer wall of the second guide post 14. One end of the spring 15 is fixedly connected to one end of the slider 16, and the other end of the spring 15 is fixedly connected to one end of the first guide post 12. A connecting plate 17 is fixedly connected to the outer wall of the first guide post 12, and a connecting post 18 is fixedly connected to the inner wall of the connecting plate 17. When the first guide post 12 moves forward, it will drive the connecting plate 17 and the connecting post 18 to move forward for locking.

[0030] Example 2:

[0031] Reference Figure 1 and Figure 3The outer wall of the connecting column 18 is slidably connected to a groove 11. The connecting column 18 slides into the groove 11, which has an upward slope, allowing the connecting column 18 to press against the inside of the groove 11, thus driving the guide column 19 to press down. The control box 6 is equipped with the guide column 19 and a spring 20. The guide column 19 presses down on the spring 20, which locks the top slider 16 through a buckle. One end of the spring 20 is fixedly connected to the bottom of the guide column 19, and the other end is fixedly connected to the inside of the control box 6. The outer wall of the body 1 is fixedly connected to a module compartment 2. The outer wall of the body 1 is equipped with a display area 3. The outer wall of the body 1 is rotatably connected to an adjustment knob 5. The outer wall of the body 1 is equipped with an operation panel 4. The outer wall of the control box 6 is fixedly connected to a terminal 7. The outer wall of the control box 6 is rotatably connected to an adjustment knob 5. The device has a knob 8, an inlet 9 on the outer wall of the body 1, a base 21 inside the body 1, which serves as the supporting foundation for the entire device and integrates a temperature control module. A valve 23 is installed on the outer wall of the base 21. A container 22 is fixedly connected to the top of the base 21. The container 22 is the core reaction chamber used to contain the raw materials for the technetium-99m marking reaction. A flange 25 is fixedly connected to the top of the container 22. The flange 25 is located at the connection between the top of the container 22 and the top cover. It adopts a metal flange 25 structure with a sealing ring and is fastened with bolts to achieve a high-strength seal, ensuring the airtightness of the reaction chamber. A top interface 24 is fixedly connected to the top of the flange 25. A central tube 26 is installed inside the container 22. The central tube 26 runs through the main channel inside the container 22 and mainly transmits the temperature control medium. A branch tube 27 is installed inside the container 22.

[0032] Working principle: When using this synthesis device for improving the radionuclear purity of technetium-99m labeled drugs, firstly, by pressing button 10, spring 13 is squeezed, which drives the connecting plate 17 connected to the bottom of button 10 to push the connecting post 18. The connecting post 18 contacts the groove 11 inside the guide post 19. The groove 11 has an upward slope, so when the connecting post 18 is squeezed in, it will drive the guide post 19 to press down, thereby causing the slider 16 to pass through the protrusion on the top of the guide post 19 and be fixed. When it is necessary to unlock, simply squeeze again. Releasing spring 13 and spring 20 will cause them to spring back, thus unlocking the device.

[0033] When using the laboratory aerosol-proof centrifuge safety cover, the temperature-controlled medium first enters the temperature control system of the base 21 through valve 23, circulating within the container 22 via the central tube 26 and branch tubes 27, thus heating or cooling the reaction environment inside the container 22. Simultaneously, the reaction materials required for technetium-99m labeling are injected into the container 22 through the top interface 24, where the labeling reaction takes place. The structure of the central tube 26 and branch tubes 27 ensures uniform distribution of the temperature-controlled medium, guaranteeing the stability of the reaction temperature. The panel of the base 21 is used to set temperature control parameters and monitor the reaction status, while the top flange 25 provides a sealed connection between the container 22 and the top assembly, ensuring the airtightness of the reaction system. Through the circulation of the temperature-controlled medium, the injection of materials, and the synergistic effect of various components, a precise temperature-controlled environment is provided for the synthesis of technetium-99m labeled drugs, laying the foundation for subsequent improvements in radionuclear purity.

[0034] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A synthetic apparatus for improving the radionuclear purity of technetium-99m labeled drugs, comprising a body (1), characterized in that: The control box (6) is slidably connected inside the body (1), and the control box (6) is provided with a connecting component; The connecting assembly includes a second guide post (14), the outer wall of which is slidably connected to the inner wall of the control box (6). A slider (16) is fixedly connected to the outer wall of the second guide post (14). A button (10) is fixedly connected to one end of the second guide post (14). A first guide post (12) is slidably connected to the outer wall of the second guide post (14). A first spring (13) is provided on the outer wall of the first guide post (12). One end of the first spring (13) is fixedly connected to the first guide post (12). 12) One end of the spring (13) is fixedly connected to the outer end of the control box (6). The outer wall of the guide post (14) is provided with a spring (15). One end of the spring (15) is fixedly connected to one end of the slider (16). The other end of the spring (15) is fixedly connected to one end of the guide post (12). The outer wall of the guide post (12) is fixedly connected with a connecting plate (17). The inner wall of the connecting plate (17) is fixedly connected with a connecting post (18).

2. The synthetic apparatus for improving the radionuclear purity of technetium-99m labeled drugs according to claim 1, characterized in that: The outer wall of the connecting column (18) is slidably connected with a groove (11). The control box (6) is provided with a guide column three (19) and a spring three (20). One end of the spring three (20) is fixedly connected to the bottom end of the guide column three (19), and the other end of the spring three (20) is fixedly connected to the inner end of the control box (6).

3. The synthetic apparatus for improving the radionuclear purity of technetium-99m labeled drugs according to claim 1, characterized in that: The outer wall of the machine body (1) is fixedly connected to a module compartment (2), the outer wall of the machine body (1) is provided with a display area (3), the outer wall of the machine body (1) is rotatably connected to an adjustment knob (5), the outer wall of the machine body (1) is provided with an operation panel (4), the outer wall of the control box (6) is fixedly connected to a terminal (7), the outer wall of the control box (6) is rotatably connected to an adjustment knob (8), and the outer wall of the machine body (1) is provided with a sample inlet (9).

4. The synthetic apparatus for improving the radionuclear purity of technetium-99m labeled drugs according to claim 1, characterized in that: The body (1) has a base (21) inside, and a valve (23) is provided on the outer wall of the base (21).

5. The synthetic apparatus for improving the radionuclear purity of technetium-99m labeled drugs according to claim 4, characterized in that: A container (22) is fixedly connected to the top of the base (21), a flange (25) is fixedly connected to the top of the container (22), and a top interface (24) is fixedly connected to the top of the flange (25).

6. The synthetic apparatus for improving the radionuclear purity of technetium-99m labeled drugs according to claim 5, characterized in that: The container (22) has a central tube (26) inside and a branch tube (27) inside.

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