A filling head for high-speed filling of large-volume infusion solutions

Abstract

The utility model relates to the field of infusion filling machine discloses a filling head for large infusion high -speed filling machine, including mounting seat and filling pipe, be provided with the filling channel for the medicinal liquid flow in mounting seat and filling pipe, and the filling channel is by first channel, second channel and third channel is composed, second channel and third channel are located in the inside of filling pipe, first channel is located in mounting seat and filling pipe, second channel is located between first channel and third channel, and the flow direction of medicinal liquid in filling channel is from first channel to third channel, and, the flow -through pipe diameter of filling channel from first channel to third channel reduces gradually. The utility model discloses three -stage gradually changing aperture flow channel structure through being designed in the inside of filling head, and the diameter of medicinal liquid flow -through channel changes gradually, realizes the smooth transition of medicinal liquid flow rate, and the generation of turbulent flow and bubble is reduced greatly, and water hammer effect is almost eliminated simultaneously, thereby improves the filling accuracy, improves the filling amount consistency between the same batch product.

Description

Technical Field

[0001] This utility model relates to the field of large-volume infusion filling machines, and in particular to a filling head for a high-speed large-volume infusion filling machine. Background Technology

[0002] Large-volume parenteral filling machines are key equipment in the pharmaceutical industry used to quantitatively fill liquid medicines into containers such as infusion bags and medicine bottles. The filling mechanism of a large-volume parenteral filling machine mainly consists of a material cylinder, a feeding pipe, a control valve, a weighing module, and a filling head.

[0003] During production, the dispensing station uses an automated dispensing system to pressurize the prepared medication from the dilution tank using a medication pump, and then delivers it through pipelines to the feed cylinder of the large-volume infusion filling machine, according to the production line's production plan. Several medication bends are designed below the feed cylinder, each with a pneumatic control valve installed below it. A weighing module controls the opening and closing of these valves. Below each pneumatic control valve is a filling head, and below each filling head is a corresponding filling finger for holding infusion bags, medicine bottles, and other containers.

[0004] The existing filling head is a straight tube with an inner diameter of 8mm and an outer diameter of 14mm, made of high-quality materials such as 316L stainless steel. The inner wall of the filling head that contacts the liquid can be machined to a mirror surface with a roughness of ≤0.6μm, and is designed with a dead-angle-free structure for easy cleaning and sterilization.

[0005] During production, it was found that when using the aforementioned fixed-aperture filling head, the large-volume parenteral solution filling machine is prone to unstable filling volume, resulting in a low product qualification rate. Specifically, at the moment the air control valve is closed after filling, due to the hysteresis effect of the liquid, the amount of residual liquid dripping (due to the large volume of the straight tube and the high flow rate, the amount of dripping is relatively large) is uncontrollable, leading to unstable filling volume; the high flow rate of the liquid and the large orifice of the filling head generate air bubbles and turbulence within the filling head; and a severe water hammer effect occurs at the moment the air control valve opens and closes, which greatly affects the filling accuracy, thus requiring improvement. Utility Model Content

[0006] To address the problems existing in the prior art, such as the tendency for air bubbles and turbulence to form inside the existing straight-tube filling head during filling, and the severe water hammer effect that occurs at the moment the pneumatic control valve opens and closes, affecting filling accuracy, this invention aims to provide a filling head for a high-speed filling machine for large-volume infusions. By designing a three-stage gradually changing orifice flow channel structure inside the filling head, the diameter of the liquid flow channel changes step by step, achieving a smooth transition of liquid flow rate, significantly reducing turbulence and air bubble generation, and almost eliminating the water hammer effect, thereby improving filling accuracy and consistency of filling volume among products in the same batch.

[0007] To achieve the above objectives, the technical solution of this utility model is as follows: A filling head for a high-speed large-volume parenteral solution filling machine includes a mounting base and a filling tube. The mounting base and filling tube are provided with filling channels for the flow of the medication. The mounting base and filling tube are integrally formed and their axes coincide. The filling channel consists of a first channel, a second channel, and a third channel. The second and third channels are located inside the filling tube and their axes coincide with the axis of the filling tube. The first channel is located inside the mounting base and filling tube, and the second channel is located between the first and third channels. The axes of the first and second channels coincide. The flow direction of the medication within the filling channel is from the first channel to the third channel. Furthermore, the diameter of the flow tube gradually decreases from the first channel to the third channel.

[0008] The present invention is further configured such that the diameter of the inflow end of the first channel, the second channel and the third channel is larger than the diameter of the outflow end of the drug.

[0009] The present invention is further configured such that the included angles between the sidewalls of the first channel, the second channel and the third channel and the axis are denoted as α, β and θ respectively, and α < β < θ.

[0010] The present invention is further configured such that α is 5.8 degrees, β is 6 degrees, and θ is 6.2 degrees.

[0011] The present invention is further configured such that: the lengths of the first channel, the second channel, and the third channel are denoted as L1, L2, and L3, respectively, then L1 <L2<L3。

[0012] The present invention is further configured such that the ratio between L1, L2 and L3 is 12:15:19.

[0013] The present invention is further configured such that: the diameter of the inflow end of the first channel is 9mm and the diameter of the outflow end is 8mm; the diameter of the inflow end of the second channel is 8mm and the diameter of the outflow end is 7mm; and the diameter of the inflow end of the third channel is 7mm and the diameter of the outflow end is 4mm.

[0014] In summary, the beneficial effects achieved by this utility model are as follows: The three-stage variable-diameter filling channel inside the filling head gradually reduces the volume of the filling channel by gradually narrowing the orifice, thus slowing down the flow rate of the liquid in the filling channel and resulting in less and more controllable residual liquid dripping. In addition, it significantly reduces the generation of turbulence and air bubbles in the filling head, and almost eliminates the water hammer effect generated when the pneumatic control valve is opened and closed, thereby improving filling accuracy and systematically solving the long-standing problem of large fluctuations in the filling volume of the same batch of products in the large-volume parenteral solution filling industry. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the specification will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0016] Figure 1 This is a schematic diagram of the filling head for a high-speed filling machine for large-volume infusions according to this utility model. Figure 1 ; Figure 2 This is a schematic diagram of the filling head for a high-speed filling machine for large-volume infusions according to this utility model. Figure 2 .

[0017] In the diagram: 1. Mounting base; 2. Filling pipe; 3. Filling channel; 31. First channel; 32. Second channel; 33. Third channel. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, not all embodiments. For ease of explanation, the terms "vertical", "horizontal", "left", "right", "upper", "lower", "inner", "outer", "bottom", etc., used in this specification to indicate the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0019] Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0020] As attached Figure 1-2 As shown, a filling head for a high-speed large-volume infusion filling machine includes a mounting base 1 and a filling tube 2.

[0021] Mounting base 1 is a disc-shaped structure used to connect to the filling machine. The mounting plate and filling tube 2 are integrally formed and their axes coincide. A filling channel 3 for the flow of liquid medicine is provided inside the mounting base 1 and the filling tube 2.

[0022] The filling channel 3 consists of a first channel 31, a second channel 32, and a third channel 33. The second channel 32 and the third channel 33 are located inside the filling tube 2, while the first channel 31 is located inside the mounting base 1 and the filling tube 2.

[0023] The first channel 31, the second channel 32 and the third channel 33 are all tapered cylindrical channels, and the axes of the three channels all coincide with the axis of the filling pipe 2. The second channel 32 is located between the first channel 31 and the third channel 33, and the first channel 31, the second channel 32 and the third channel 33 are in sequential communication. Moreover, the flow direction of the liquid medicine in the filling channel 3 is from the first channel 31 to the third channel 33.

[0024] In the flow direction of the liquid medicine, the diameter of the liquid medicine inlet end of each of the first channel 31, the second channel 32 and the third channel 33 is larger than the diameter of the respective liquid medicine outlet end, so that the flow diameter of the entire filling channel 3 from the first channel 31 to the third channel 33 decreases step by step.

[0025] Specifically, the included angles between the side walls of the first channel 31, the second channel 32 and the third channel 33 and their own axes are denoted as α, β and θ respectively, and the relationship among the three is α<β<θ, that is, the inclination angle of the side wall of the third channel 33 is the largest, while the inclination angle of the side wall of the first channel 31 is the smallest. Particularly, in this embodiment, α is 5.8 degrees, β is 6 degrees, and θ is 6.2 degrees.

[0026] Further, the lengths of the first channel 31, the second channel 32 and the third channel 33 are denoted as L1, L2 and L3 respectively, the relationship among the three is L1<L2<L3, and the proportional relationship among L1, L2 and L3 is 12:15:19.

[0027] In this embodiment, L1 is 12 mm, L2 is 15 mm, and L3 is 19 mm. Moreover, the diameter of the liquid medicine inlet end of the first channel 31 is 9 mm and the diameter of the liquid medicine outlet end thereof is 8 mm; the diameter of the liquid medicine inlet end of the second channel 32 is 8 mm and the diameter of the liquid medicine outlet end thereof is 7 mm; the diameter of the liquid medicine inlet end of the third channel 33 is 7 mm and the diameter of the liquid medicine outlet end thereof is 4 mm.

[0028] In order to verify the actual effect of the three-stage variable-diameter filling head and the common straight-tube filling head of the present utility model, the production data of filling with the three-stage variable-diameter filling head and the common straight-tube filling head are counted as follows (the filling volume is 100 ml of sodium chloride injection, and the target net weight of the filling amount is 103.22g-108.22g): Number of fillings Straight tube filling head Three-stage variable diameter filling head 1 time 105.96g 105.43g 2 times 104.32g 105.67g 3 times 105.80g 105.65g 4 times 103.56g 105.77g 5 times 106.35g 105.96g 6 times 107.32g 105.79g 7 times 106.53g 106.11g 8 times 108.23g 106.21g 9 times 105.45g 105.23g 10 times 106.23g 105.98g 11 times 103.89g 105.78g 12 times 106.23g 106.15g 13 times 105.68g 105.98g 14 times 106.56g 105.31g 15 times 107.26g 105.23g 16 times 106.52g 105.77g 17 times 106.53g 105.31g 18 times 106.53g 105.66g 19 times 106.53g 105.62g 20 times 106.55g 105.78g 21 times 105.23g 105.77g 22 times 104.27g 105.32g 23 times 105.26g 105.64g 24 times 107.89g 105.21g 25 times 107.65g 105.23g 26 times 103.45g 105.99g 27 times 106.45g 105.78g 28 times 107.56g 105.98g 29 times 106.53g 105.33g 30 times 106.52g 105.27g 31 times 105.56g 105.78g 32 times 105.63g 105.88g 33 times 107.23g 105.32g 34 times 107.56g 105.67g 35 times 106.78g 105.35g 36 times 107.58g 105.33g 37 times 106.22g 105.97g 38 times 107.02g 106.02g 39 times 105.32g 105.32g 40 times 106.52g 105.32g 41 times 106.35g 105.98g 42 times 108.52g 106.22g 43 times 105.77g 105.32g 44 times 106.23g 105.77g 45 times 105.96g 105.62g 46 times 105.33g 105.77g 47 times 105.78g 105.32g 48 times 106.11g 105.32g 49 times 105.64g 105.28g 50 times 105.87g 105.78g According to the above production data, the maximum filling volume using the common straight-tube filling head is 108.52g, which has exceeded the target net weight range, and the minimum is 103.56g, with a difference of 4.96g between the maximum and the minimum in the same batch, and the filling volume fluctuates greatly.

[0029] The filling volume using the three-stage variable diameter filling head ranges from a maximum of 106.22g to a minimum of 105.21g, both within the target net weight range. Moreover, the difference between the same batch is only 1.01g, indicating small fluctuations in filling volume and significantly improved filling accuracy and consistency.

[0030] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including both the preferred embodiments and all changes and modifications falling within the scope of the present invention. Clearly, those skilled in the art can make various alterations and modifications to the present invention without departing from its spirit and scope. Thus, if such modifications and modifications fall within the scope of the claims of the present invention and their equivalents, the present invention also intends to include such modifications and modifications.

Claims

1. A filling head for a high-speed large-volume infusion filling machine, comprising a mounting base (1) and a filling tube (2), wherein the mounting base (1) and the filling tube (2) are provided with a filling channel (3) for the flow of the liquid medicine, characterized in that, The mounting base (1) and the filling tube (2) are integrally arranged and their axes coincide. The filling channel (3) is composed of a first channel (31), a second channel (32) and a third channel (33). The second channel (32) and the third channel (33) are located inside the filling tube (2) and their axes coincide with those of the filling tube (2). The first channel (31) is located inside the mounting base (1) and the filling tube (2). The second channel (32) is located between the first channel (31) and the third channel (33). The axes of the first channel (31) and the second channel (32) coincide. The flow direction of the liquid in the filling channel (3) is from the first channel (31) to the third channel (33). Furthermore, the flow diameter of the filling channel (3) decreases step by step from the first channel (31) to the third channel (33).

2. The filling head for a high-speed large-volume infusion filling machine according to claim 1, characterized in that, The diameter of the inflow end of the first channel (31), the second channel (32) and the third channel (33) is larger than the diameter of the outflow end of the drug.

3. The filling head for a high-speed large-volume infusion filling machine according to claim 2, characterized in that, The angles between the sidewalls of the first channel (31), the second channel (32), and the third channel (33) and the axis are denoted as α, β, and θ, respectively, where α < β < θ.

4. The filling head for a high-speed large-volume infusion filling machine according to claim 3, characterized in that, α is 5.8 degrees, β is 6 degrees, and θ is 6.2 degrees.

5. The filling head for a high-speed large-volume infusion filling machine according to claim 1, characterized in that, The lengths of the first channel (31), the second channel (32), and the third channel (33) are denoted as L1, L2, and L3, respectively. Then, L1 <L2<L3。 6. The filling head for a high-speed filling machine for large-volume infusions according to claim 5, characterized in that, The ratio between L1, L2 and L3 is 12:15:

19.

7. The filling head for a high-speed filling machine for large-volume infusions according to any one of claims 1-6, characterized in that, The diameter of the inlet end of the first channel (31) is 9 mm and the diameter of the outlet end is 8 mm. The diameter of the inlet end of the second channel (32) is 8 mm and the diameter of the outlet end is 7 mm. The diameter of the inlet end of the third channel (33) is 7 mm and the diameter of the outlet end is 4 mm.

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