Multi-temperature zone smart transport packaging for mass spectrometry reagents

Abstract

The utility model belongs to medical instrument and biological reagent packing technical field, concretely relates to a kind of multi-temperature zone intelligent transportation packing box for mass spectrum reagent, including box cover and box body, the box body is separated into freezing store and refrigeration store by detachable connecting structure inside up and down, two store box body is constituted by custom solid-state phase change cold storage plate, and stainless steel bottom plate is equipped in refrigeration store bottom and is spliced into complete cavity with U solid-state phase change cold storage plate;The freezing store and refrigeration store bottom are equipped with the buffer heat-insulating sponge with different aperture to fix different specifications reagent bottle, and the side of box body is equipped with the independent consumable store with specific clamping, and still integrate intelligent perception and tracing system in box.The utility model effectively solves mass spectrum reagent multi-temperature zone transportation, temperature monitoring and consumable integration problem, realizes reagent transportation whole-process visualized tracing and efficient management, and is applicable to clinical test and multicenter research etc.

Description

Technical Field

[0001] This utility model belongs to the field of medical device and biological reagent packaging technology, specifically, it relates to a multi-temperature zone intelligent transport packaging box for mass spectrometry reagents. Background Technology

[0002] In clinical diagnostics and life science research, mass spectrometry is widely used due to its high sensitivity and specificity. However, this technology requires various temperature-sensitive reagents, such as calibrators that must be frozen at -20°C and buffer solutions that need to be refrigerated between 2 and 8°C. Even minute temperature deviations during transportation can reduce reagent activity or even render them ineffective, thus affecting the accuracy of subsequent test results. Therefore, stringent requirements are placed on the temperature control, ease of management, and safety of mass spectrometry reagent transport packaging.

[0003] Currently, there are many problems in the transportation of mass spectrometry reagents, which seriously restrict the safety and efficiency of reagent transportation. Specifically, these problems include: Repackaging and transportation management is difficult: Reagents are usually transported in repackaged form. Different types and specifications of reagents lack a unified and clear management carrier, which makes it easy for confusion and mis-taking to occur. This not only increases the sorting workload before subsequent use, but may also cause testing errors due to reagent mismixing.

[0004] Mixed storage temperature interference: Most existing transport packaging is designed for a single temperature zone. If reagents with different temperature requirements are stored and transported together, the ambient temperatures of each reagent will interfere with each other, making it difficult to accurately maintain the optimal storage temperature range for each reagent. This greatly increases the risk of reagent failure, especially for low-temperature sensitive mass spectrometry reagents, where the losses caused by temperature fluctuations are more significant.

[0005] Lack of Temperature Recording and Traceability: Traditional transport packaging lacks effective temperature monitoring and recording methods, making it impossible to acquire and store real-time temperature change data throughout the reagent transportation process. If a reagent quality issue arises, it is impossible to trace the abnormal temperature points during transportation, making it difficult to determine responsibility and providing data support for reagent quality assessment.

[0006] Poor adaptability of internal space: The fixed structure inside the packaging box cannot be flexibly adjusted according to the size of reagent bottles of different specifications, which makes the reagent bottles prone to shaking and collision during transportation. This may not only damage the reagent bottle, but also affect its stability due to reagent vibration, further threatening the reliability of test results.

[0007] The transportation of consumables and reagents is not synchronized: Consumables used with mass spectrometry reagents (such as 96-well plates, centrifuge tubes, etc.) need to be packaged and transported separately. On the one hand, this increases packaging costs and the complexity of the transportation process. On the other hand, it is easy for the transportation progress of reagents and consumables to be inconsistent and to be stored separately upon receipt, which affects the rapid development of detection work and reduces experimental efficiency.

[0008] To address the aforementioned issues, some improvements have emerged in related fields. For example, patent CN219948902U discloses a biological reagent transport packaging box, which uses a multi-chamber structure to separate different reagents and employs insulation materials to improve temperature stability. However, this solution still has significant shortcomings: First, no dedicated cold storage structure was designed for the specific temperature range requirements of mass spectrometry reagents, resulting in insufficient temperature control precision and making it difficult to meet the stringent temperature requirements of mass spectrometry reagents. Secondly, the lack of an integrated intelligent sensing and traceability system makes it impossible to record temperature data and trace logistics throughout the transportation process, and the risk of reagent quality remains difficult to control. Third, the synchronous transportation needs of commonly used consumables in mass spectrometry detection were not considered, and no dedicated storage area for consumables was set up. Consumables still need to be packaged separately, making it impossible to achieve integrated transportation management of reagents and consumables. The convenience of use and transportation efficiency need to be improved.

[0009] Therefore, there is an urgent need for an integrated transport and packaging solution that can accurately control multiple temperature zones, has full temperature traceability, can be adapted to reagent bottles of different specifications, and integrates consumable storage, in order to ensure the quality and safety of mass spectrometry reagents during transportation, improve the overall efficiency of transportation and testing, and meet the actual needs of clinical trials and multi-center studies. Utility Model Content

[0010] To address the shortcomings of existing technologies, the purpose of this invention is to provide a multi-temperature zone intelligent transport packaging box for mass spectrometry reagents.

[0011] According to this utility model, a multi-temperature zone intelligent transport packaging box for mass spectrometry reagents is provided, including a box lid and a box body. The box body is divided into a freezing compartment and a refrigeration compartment by a detachable connecting structure. The boxes of the freezing compartment and the refrigeration compartment are both made of custom solid phase change cold storage plates. The bottom of the refrigeration compartment is provided with a stainless steel bottom plate. The bottom of the freezing compartment and the refrigeration compartment are provided with cushioning and heat-insulating sponges with different pore sizes. An independent consumables compartment is provided on one side of the box body. An intelligent sensing and traceability system is integrated into the box body.

[0012] In a preferred embodiment: the detachable connection structure is a snap-fit ​​or slide rail mechanism, which realizes the detachable connection between the freezer compartment and the refrigerator compartment through snap-fit ​​engagement or slide rail sliding.

[0013] In a preferred embodiment: the phase change temperature of the solid phase change cold storage plate corresponding to the freezing chamber is -18°C to -22°C, and the phase change temperature of the solid phase change cold storage plate corresponding to the refrigeration chamber is 2°C to 8°C.

[0014] In a preferred embodiment: the stainless steel base plate and the U-shaped solid phase change cold storage plate of the cold storage compartment are connected by an embedded slot, and the joint between the two is sealed with food-grade silicone.

[0015] In a preferred embodiment: the buffer insulation sponge is a polyurethane slow rebound sponge, and the pore size on the sponge is adapted to mass spectrometry reagent bottles of different specifications.

[0016] In a preferred embodiment: the independent consumables compartment is provided with a 96-well plate holder and a centrifuge tube holder, the 96-well plate holder being adapted to the shape of the 96-well plate, and the centrifuge tube holder being adapted to the shape of the centrifuge tube box.

[0017] In a preferred embodiment: both the 96-well plate holder and the centrifuge tube holder are made of elastic TPU material, and the 96-well plate and the centrifuge tube are clamped and fixed by the elastic deformation of the TPU material.

[0018] In a preferred embodiment: the intelligent sensing and traceability system integrates an RFID chip, a Bluetooth temperature sensor and a rechargeable lithium battery. The Bluetooth temperature sensor is connected to two wireless temperature probes, which extend into the freezer compartment and the refrigerated compartment respectively.

[0019] In a preferred embodiment: the edge of the lid is provided with a magnetic sealing strip, which is made of EPDM rubber wrapped with neodymium iron boron magnetic sheet. When the lid is closed, the lid and the box body are sealed and fitted by magnetic adsorption.

[0020] In a preferred embodiment: both the lid and the body are made of ABS plastic injection molding.

[0021] Compared with the prior art, the present invention has the following beneficial effects: 1. This utility model constructs a freezing chamber and a refrigeration chamber by customizing a solid phase change cold storage plate, which can be adapted to the different temperature requirements of mass spectrometry reagents, avoid temperature interference caused by mixed storage, greatly reduce the risk of reagent failure due to temperature deviation, and ensure reagent activity and subsequent detection accuracy.

[0022] 2. The intelligent sensing and traceability system integrated in this utility model uses dual wireless temperature probes to collect temperature zone data in real time and combines it with RFID chips to record unique IDs. It can record and read temperature and logistics information throughout the process, which facilitates the tracing of abnormal nodes, clarifies responsibilities, and provides data support for reagent quality assessment.

[0023] 3. The bottom of the freezing compartment and the refrigeration compartment of this utility model is made of polyurethane slow rebound sponge with different pore sizes, which can be used to fit reagent bottles of different specifications. It can stably fix the reagent bottles, prevent shaking and collision during transportation, protect the stability of the bottle and reagent, and reduce the causes of detection errors.

[0024] 4. This utility model features an independent consumable compartment with elastic TPU slots to fix the 96-well plate and centrifuge tube box, realizing integrated transportation of reagents and consumables, avoiding asynchronous transportation of the two, reducing packaging costs, and improving the efficiency of test preparation.

[0025] 5. The magnetic sealing strip of the box lid of this utility model achieves a tight seal. Combined with the heat storage plate and sponge insulation, it reduces the influence of external temperature, prolongs the constant temperature time, and meets the needs of long-distance transportation of mass spectrometry reagents. Attached Figure Description

[0026] Other features, objects, and advantages of this invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings: Figure 1 This is a cross-sectional schematic diagram of the overall structure of this utility model.

[0027] Figure 2 This is a schematic diagram of the structure of the magnetic sealing strip of this utility model.

[0028] Figure 3 This is a structural schematic diagram of the detachable connection mechanism of this utility model.

[0029] Figure 4 This is a schematic diagram of the structure of the freezer compartment and the refrigerated compartment of this utility model.

[0030] Figure 5 This is a schematic diagram of the consumables compartment of this utility model.

[0031] The following are the labeling elements in the figure: 1. Lid; 2. Box body; 3. Freezing compartment; 3a. Solid phase change cold storage plate in the freezing compartment; 3b. Sponge for fixing reagent bottles in the freezing compartment; 4. Refrigerated compartment; 4a. Solid phase change cold storage plate in the refrigerated compartment; 4b. Stainless steel base plate; 4c. Sponge for fixing reagent bottles in the refrigerated compartment; 5. Consumables compartment; 5a. 96-well plate holder; 5b. Centrifuge tube holder; 6. Intelligent sensing and traceability system module; 7. Wireless temperature probe; 8. Magnetic sealing strip; 9. Detachable connection mechanism. Detailed Implementation

[0032] The present invention will now be described in detail with reference to specific embodiments. These embodiments will help those skilled in the art to further understand the present invention, but do not limit the present invention in any way. It should be noted that those skilled in the art can make several changes and improvements without departing from the concept of the present invention. These all fall within the protection scope of the present invention.

[0033] like Figures 1-5 As shown, this utility model discloses a multi-temperature zone intelligent transport packaging box for mass spectrometry reagents, including a box cover 1 and a box body 2. The box body 2 and the box cover 1 are injection molded from ABS plastic. ABS plastic has good impact resistance, heat resistance and chemical corrosion resistance, ensuring the overall structural strength and durability of the packaging box.

[0034] The box body 2 is divided into a freezer compartment 3 and a refrigerator compartment 4 by a detachable connecting structure 9. The detachable connecting structure 9 is a snap-on or sliding rail mechanism, which makes the installation and removal of the freezer compartment 3 and the refrigerator compartment 4 more convenient, and facilitates the cleaning, maintenance or replacement of the compartments.

[0035] Both the freezer compartment 3 and the refrigerated compartment 4 are constructed using custom-made solid-state phase change cold storage plates. The phase change temperature of the solid-state phase change cold storage plate 3a in the freezer compartment is -18℃ to -22℃, providing a suitable low-temperature environment for reagents requiring frozen storage. The phase change temperature of the solid-state phase change cold storage plate 4a in the refrigerated compartment is 2℃ to 8℃, meeting the storage temperature requirements for refrigerated reagents. The solid-state phase change cold storage plates feature large cold storage capacity, slow and stable cold release, providing long-term constant temperature protection for reagent transportation.

[0036] The bottom of the cold storage compartment 4 is equipped with a stainless steel base plate 4b, which is connected to the U-shaped solid-state phase change cold storage plate 4a via an embedded slot. Food-grade silicone is evenly applied to the joint for sealing, ensuring the airtightness of the cold storage compartment 4 and preventing temperature leakage. The stainless steel base plate 4b not only enhances the thermal conductivity of the cold storage compartment but also improves the structural stability of the compartment. The embedded slot connection method, combined with the food-grade silicone seal, effectively ensures the airtightness of the cold storage compartment, prevents internal temperature leakage, and ensures the refrigeration effect.

[0037] Both the freezing chamber 3 and the refrigeration chamber 4 have cushioning and insulating sponges with different pore sizes at their bottoms. A freezing chamber reagent bottle fixing sponge 3b is attached to the bottom of the freezing chamber 3, and a refrigeration chamber reagent bottle fixing sponge 4c is attached to the bottom of the refrigeration chamber 4. The cushioning and insulating sponges are made of polyurethane slow-rebound foam, which has excellent cushioning and insulation properties. It effectively secures reagent bottles of different sizes, preventing them from shaking or colliding during transportation, and also reduces heat exchange between the chamber and the outside environment, further maintaining a stable temperature inside the chamber. The pore size of the cushioning and insulating sponges is adapted to different sizes of reagent bottles, meeting the fixing requirements of mass spectrometry reagent bottles of various sizes.

[0038] One side of the box 2 has an independent consumables compartment 5, which contains a 96-well plate holder 5a and a centrifuge tube holder 5b. Both the 96-well plate holder 5a and the centrifuge tube holder 5b are made of elastic TPU material. The elastic TPU material has good elasticity and flexibility, allowing it to tightly fit the 96-well plate and centrifuge tube holder, effectively securing the consumables and preventing them from shifting during transportation. The independent consumables compartment design enables integrated transportation of reagents and consumables, eliminating the need for separate packaging, facilitating use, and improving transportation and usage efficiency.

[0039] The intelligent sensing and traceability system module 6 is integrated and installed on the inner wall of the box 2. Module 6 includes an RFID chip, a Bluetooth temperature sensor, and a rechargeable lithium battery. The RFID chip assigns a unique ID to each box, facilitating identification and management. The Bluetooth temperature sensor, via temperature probe 7, collects real-time temperature data from the frozen compartment 3 and the refrigerated compartment 4, storing the data in the chip. The rechargeable lithium battery provides continuous power to the intelligent sensing and traceability system 6, ensuring its normal operation throughout the transportation process. By bringing a handheld device close to the box, the unique ID in the RFID / NFC tag and the temperature data collected by the wireless temperature sensor module can be read without opening the box, enabling visualized traceability of the entire reagent transportation process. This allows for timely monitoring of temperature changes during transport, ensuring reagent quality. Two wireless temperature probes 7 extend from the intelligent sensing and traceability system module 6, one extending to the center of the frozen compartment 3 and the other to the center of the refrigerated compartment 4, accurately collecting temperature data from both compartments.

[0040] The edge of the box lid 1 is provided with a magnetic sealing strip 8. The magnetic sealing strip 8 is made of EPDM rubber wrapped with neodymium iron boron magnetic sheet. EPDM rubber has good weather resistance, aging resistance and sealing performance. The neodymium iron boron magnetic sheet has strong magnetism, which can make the box lid 1 fit tightly with the box body 2, effectively enhance the overall sealing of the packaging box, reduce the influence of the external environment on the temperature inside the box, and further ensure the stability of the temperature inside the warehouse.

[0041] Working principle Before using this utility model, it is necessary to perform pre-cooling treatment: place the freezing chamber 3 in a freezing device at -25℃ and freeze for 12 hours to allow the solid phase change cold storage plate 3a of the freezing chamber to fully store cold; place the refrigeration chamber 4 in a refrigeration device at 4℃ and pre-cool for 6 hours to allow the solid phase change cold storage plate 4a of the refrigeration chamber to reach a stable refrigeration temperature.

[0042] After precooling, staff place mass spectrometry reagents requiring cryopreservation, such as calibrators, into the corresponding wells of the reagent bottle fixing sponge 3b in the cryopreservation chamber 3, and mass spectrometry reagents requiring refrigeration, such as buffer solutions, into the corresponding wells of the reagent bottle fixing sponge 4c in the refrigeration chamber 4. Then, a 96-well plate is placed into the 96-well plate slot 5a, and a centrifuge tube box is placed into the centrifuge tube box slot 5b. The lid 1 is then closed. At this point, the intelligent sensing and traceability system module 6 automatically starts working. The RFID chip records the unique ID information of the packaging box, and the Bluetooth temperature sensor collects the temperature data in the cryopreservation chamber 3 and refrigeration chamber 4 in real time through the wireless temperature probe 7. The temperature data is then associated with the unique ID information and stored in the system.

[0043] During transportation, transport personnel can use handheld devices supporting Bluetooth and RFID / NFC reading functions, such as smartphones or dedicated handheld terminals, to establish a Bluetooth connection with the intelligent sensing and traceability system module 6 by simply bringing the device close to the packaging box. Without opening the box, the device reads the stored temperature data and unique ID information, allowing real-time monitoring of temperature changes within the frozen compartment 3 and the refrigerated compartment 4, as well as the reagent information corresponding to the packaging box. Simultaneously, the handheld device can also upload the read temperature data and unique ID information to the logistics management platform, enabling real-time monitoring and data recording throughout the reagent transportation process.

[0044] Once the reagents arrive at their destination, the receiving staff will use a handheld device to read the temperature data and unique ID information inside the packaging box. By checking the temperature data, they can determine whether the reagents have been kept in a suitable temperature environment throughout the transportation process. If the temperature data is within the specified range, it means that the quality of the reagents has not been affected and they can be received and used normally. If any abnormalities are found in the temperature data, the relevant circumstances during the transportation process can be traced based on the unique ID information, the cause of the abnormality can be analyzed, and appropriate measures can be taken in a timely manner.

[0045] Actual testing showed that, under an ambient temperature of 25°C, the packaging box could maintain a stable temperature of -20±3°C inside the freezer compartment 3 for more than 48 hours and a stable temperature of 5±3°C inside the refrigerated compartment 4 for more than 60 hours, fully meeting the temperature requirements for long-distance transportation of mass spectrometry reagents. The intelligent sensing and traceability system module 6, after being fully charged, can work continuously for more than 7 days, covering the transportation cycle of most mass spectrometry reagents.

[0046] In the description of this application, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0047] The specific embodiments of this utility model have been described above. It should be understood that this utility model is not limited to the specific embodiments described above, and those skilled in the art can make various changes or modifications within the scope of the claims, which do not affect the substantive content of this utility model. Unless otherwise specified, the embodiments and features described in this application can be arbitrarily combined with each other.

Claims

1. A multi-temperature zone intelligent transport packaging box for mass spectrometry reagents, characterized in that, Includes a lid (1) and a box body (2). The box body (2) is divided into a freezer compartment (3) and a refrigerator compartment (4) by a detachable connection structure (9). The boxes of the freezer compartment (3) and the refrigerator compartment (4) are both made of solid phase change cold storage plates. The bottom of the refrigerator compartment (4) is provided with a stainless steel base plate (4b). The bottom of the freezer compartment (3) and the refrigerator compartment (4) are both provided with cushioning and heat-insulating sponges with different pore sizes. An independent consumables compartment (5) is provided on one side of the box body (2). The box body (2) integrates an intelligent sensing and traceability system (6).

2. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, The detachable connection structure (9) is a snap-fit ​​or slide rail mechanism, which realizes the detachable connection between the freezer compartment (3) and the refrigerator compartment (4) by snap-fit ​​or slide rail.

3. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, The phase change temperature of the solid phase change cold storage plate (3a) corresponding to the frozen compartment (3) is -18℃ to -22℃, and the phase change temperature of the solid phase change cold storage plate (4a) corresponding to the refrigerated compartment (4) is 2℃ to 8℃.

4. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, The stainless steel base plate (4b) and the U-shaped solid phase change cold storage plate (4a) of the cold storage compartment (4) are connected by an embedded slot, and the joint between the two is sealed with food-grade silicone.

5. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, The cushioning and heat-insulating sponge is a slow-rebound polyurethane sponge, and the pore size on the sponge is adapted to mass spectrometry reagent bottles of different sizes.

6. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, The independent consumables compartment (5) is equipped with a 96-well plate holder (5a) and a centrifuge tube holder (5b). The 96-well plate holder (5a) is adapted to the shape of the 96-well plate, and the centrifuge tube holder (5b) is adapted to the shape of the centrifuge tube box.

7. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 6, characterized in that, Both the 96-well plate holder (5a) and the centrifuge tube holder (5b) are made of elastic TPU material, and the 96-well plate and centrifuge tube are clamped and fixed by the elastic deformation of the TPU material.

8. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, The intelligent sensing and traceability system (6) integrates an RFID chip, a Bluetooth temperature sensor and a rechargeable lithium battery. The Bluetooth temperature sensor is connected to two wireless temperature probes (7), which extend into the freezer compartment (3) and the refrigerator compartment (4) respectively.

9. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, The edge of the lid (1) is provided with a magnetic sealing strip (8). The magnetic sealing strip (8) is made of EPDM rubber wrapped with neodymium iron boron magnetic sheet. When the lid (1) is closed, the lid (1) and the box body (2) are sealed and fitted by magnetic adsorption.

10. The multi-temperature zone intelligent transport packaging box for mass spectrometry reagents according to claim 1, characterized in that, Both the lid (1) and the body (2) are made of ABS plastic injection molding.

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