COMPOSITIONS AND METHODS FOR INCREASING OR ENHANCED TRANSMISSION OF GENE THERAPY VECTORS AND FOR REMOVAL OR REDUCTION OF IMMUNOGLOBURINS

Abstract

Disclosed herein are methods for treating patients who may develop or have pre-existing neutralizing gene therapy antibodies by administering a protease that cleaves peptide bonds present in immunoglobulins or by administering a glycosidase that cleaves carbohydrate residues present in immunoglobulins, or other similar enzyme cleavage of immunoglobulins in vivo. Also disclosed are methods for using IdeS and other immunoglobulin G degrading enzyme polypeptides for gene therapy treatment of a disease in a patient in need thereof.