Cosmetic and / or dermatological formulation, process for its preparation and use of the formulation

Abstract

Cosmetic and / or dermatological formulation containing cosmetic and / or dermatological active ingredients, as well as auxiliary and base substances, wherein metallic silver and an active ingredient which improves and / or increases the water-binding capacity of the skin are contained as active ingredients, characterized in that the silver is porous, wherein the specific surface area of the porous silver is in the range of 2 to 6 m 2 / g is measured volumetrically using BET N2 adsorption.

Description

The invention relates to a cosmetic and / or dermatological formulation which can be used in particular for the comfort and care of pruritic and strained skin.Strained, cracked and / or pruritic skin can have a variety of causes, for example also dermatitis or eczema. In humans with an inclination to atopic eczema, the barrier function of the horny layer of the scalp is usually disturbed. The scalp itself consists of four cell layers. The cells of the scalp permeate through these four cell layers approximately within four weeks. In the lowermost layer of the scalp, the basal cell layer, the cells form by cell division and migrate to the skin surface with changing their shape. Above the basal cell layer is the wide spike cell layer in which the cells have spike-shaped extensions. In the third grain cell layer above, the cells become smaller again and die gradually. In the outer horny layer, many layers of dead flat cells are accumulated, which are gradually ground in the form of flakes.In order to protect the living layers of the scalp from drying, the interstices of the horny cells are sealed against water escape and entry and thus form a barrier. This barrier is made up of the barrier lipids formed in the grain cell layer. These lipids, due to their chemical structure, arrange themselves as a double lipid membrane. This barrier is disturbed in humans with the tendency to an atopic eczema, so that they must protect their skin very well from drying out.Regardless of the cause, the term dermatitis or eczema is understood to mean inflammation of the skin. Atopic eczema (neurodermitis, atopic dermatitis, endogenous eczema) is based on a chronic skin disease which is distinguished above all by skin dryness and the tendency to form eczema (inflammations of the scalp) and itch irritation. The skin of a neurodegenerative agent is characterized in that it is drier than normal skin and has a reduced moisture storage capacity and a lack of skin fats. As already stated, the skin loses its barrier function against environmental influences, it is rough and has a greater tendency to scale. In addition, the regulation of further skin functions such as, for example, perspiration, skin blood flow and the regulation of the temperature is disturbed.To maintain the acid protection coat of the skin, healthy skin is colonized with different bacterial species, in low concentrations also with fungi. This composition of the germination population is modified in neurodermitic agents, whereby the disease can be triggered. For the aforementioned reasons, it is therefore necessary to influence skin colonization in some patients with the aid of antibiotics.Neurodermitis is frequently a genetically determined, pruritic, inflammatory skin disease whose weight-free intervals can be interrupted by outbreaks of disease of different severity. At each stage of the disease, the swelling pruriticness plays a determining role for many patients, and scratching can enhance the disease. The swelling pruriticness can lead to a similar impairment of quality of life to chronic pain. Above all, by treating skin inflammation, it is possible to silence the pruriticism.Neurodermitis can be caused in three disease phases which differ in the age of life as well as in the affected body sites. In infants, the disease often already starts with the formation of milk scab. Milk scab is characterized by yellowish white crusts in combination with wetting eczema, which can expand in a planar manner. Usually, the stretching sides of the arms and legs as well as the scalp are affected. This frequently results in infection of the affected areas of the skin with viruses and bacteria. The bending eczema refers to changes in skin in the flexo folds of the knee joints and the elbows. However, the hands, the neck and the neck are also concerned. The female bugs usually develop from the age of children and the age of adolescents, wherein in young people the skin is often reddened by inflammation and in the course of the disease an coarsening of the skin field (lichenification) forms. A special form of neurodermitis, which occurs especially in adults, is the prurigo form. It typically occurs throughout the body and is characterized by severely scratched nodes. Furthermore, neurodermitis can be divided essentially into three disease states, eczema newly occurring in the acute first stage and being retained over days to weeks. Existing older skin damage is impaired by the added new ones. Moisture, crust formation and redness of the skin are the primary factor in this stage of the disease. In the case of prolonged inflammation, the acute one goes over to a subacute stage which can last over weeks to months. Small nodules, redness and scaling of the skin occur, with neurodermitis into the chronic stage, which may last from months to years. At the chronic stage, the following skin changes occur at the same time, such as lichenification, increased scaling, enhanced keratinization (hyperkeratoses), deep skin cracks (rhagads), change in skin color (depigmentation or hyperpigmentation).Because of the phase spread of neurodermitis, treatment is particularly difficult. The greatest problems arise from the very massive pruriticness which can lead to non-suppressible scratches. These scratches are, on the one hand, an extreme stress and further damage the skin. Two aspects are therefore of particular importance to a neurodegenerative person. On the one hand, daily skin care, even in times free of adverse effects, with refatting creams, oil baths or lotions, and also the likewise most sustained use of anti-inflammatory active ingredients which have fewer side effects than the cortisone usually used. And, sustained use of antibiotics is also undesirable. These many types of requirements for skin care products become all the more urgent if the skin care products have to be applied daily, in some cases several times daily for years.DE 198 57 490 A1 discloses a formulation for use as skin protection which comprises saturated and unsaturated phosphatidylcholine, medium-chain triglycerides, salts, humectants, dermatological or cosmetic active ingredients and water. The humectants may be polyols, urea or mixtures thereof. The polyols may be glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerol, inositol (inositol), sorbitol (sorbitol), mannitol, palatinit, maltodextrin, dextrin, cyclodextrin, glucose, fructose, lactose, mannose, galactose, as well as other saccharides. Dermatologic and cosmetic active ingredients mentioned include panthenol, pantothenic acid, allantoin, colloidal silver and algae extract.DE 198 57 492 A1 discloses a formulation for use as skin protection, which formulation comprises saturated phosphatidylcholine, medium-chain triglycerides, salts, humectants, dermatological or cosmetic active ingredients and water. The moisturizing substances, dermatological and cosmetic active substances mentioned here are the same substances which are also mentioned in DE 198 57 490 A1.It is an object of the present invention to provide a formulation which is effective and long lastingly capable of killing pathogens.This object is achieved by a cosmetic and / or dermatological formulation with auxiliaries and base materials which, as cosmetic and / or dermatological active ingredients, comprises metallic silver and an active ingredient which improves and / or increases the water-binding capacity of the skin. An active ingredient promoting the water-binding capacity of the skin improves and / or increases the moisturizing capacity of the skin. These active ingredients are also referred to as moisturizers.The formulation of the invention contains the silver in a novel, highly effective particulate form. The silver is particularly preferably colloidally and / or very finely dispersed in the formulation. In order to enable the desired effect, which is achieved as efficiently as possible by slow dissolution of silver ions, which in turn prevent or destroy pathogens from growing, a highly porous surface of the metallic silver is preferred. By adjusting the specific surface area of the highly porous metallic silver, the release of active substance, i.e. the release of the silver ions, can be adjusted in a time-controlled manner. It has proven expedient to set the specific surface area in the range from 2 to 6 m 2 / g, in particular in the range from 3 to 5 m 2 / g. The specific surface area is determined volumetrically by means of the N 2- absorption according to BET.The agglomerate size of the silver particles, according to the QM system (DIN-ISO 9001), is in the range of d50 at 1 to 30 μm, preferably at 3 to 25 μm, particularly preferably at 5 to 20 μm. The ratio of d10 / d90, likewise determined according to DIN-ISO 9001, is in the range from 2 to 20, preferably from 4 to 15, and the tap density of the highly porous particulate silver is from 0.3 to 0.9, in particular from 0.5 to 0.7 g / cm 3. The purity of the highly porous colloidal silver present is greater than 99.5% based on the silver, the purity preferably being 99.9%. The colloidal silver particles are preferably produced purely physically, which can ensure that no additional chemicals, which may be irritating to the skin or have an allergenic effect, are used. The particulate highly porous silver present is preferably obtained via an ion-free production process.The continuous release of silver ions, i.e. the rate-mediated release of the antimicrobially active silver ions, can be matched to the requirement profile of the formulation via the particle size and / or via the specific surface area. Particular preference is given to the use of metallic silver present in colloidal and / or highly porous form, because the silver ions are released to the skin in a retarded manner over hours and thus permanently prevent the skin from being colonized with pathogens. Because of the large specific surface area of the silver particles, only a very small amount of silver is necessary in the formulation by weight. The content of silver can be 0.05 to 1.5 wt %, preferably 0.05 to 1.0 wt %, and particularly preferably 0.05 to 0.5 wt %. The germicidal effect of the silver ions also makes it possible to dispense with preservatives in the cream.The second active ingredient which promotes moisturizing of the skin is preferably dexpanthenol, which is also known as panthenol or provitamin B5. Panthenol improves and increases the moisturizing capacity of the skin and therefore acts as a moisturizer. It also exhibits anti-inflammatory, pruritic and wound healing action on the skin and stimulates epithelization. In addition to panthenol, derivatives of panthenol such as pantothenic acid, panthenyl ethyl ether, panthenyl ethyl ether acetate, panthenyl triacetate or further pantenol analogs can also be used as active ingredient in the formulation. In addition to the panthenol compounds, allantonin, hyaluronic acid, an algae extract, native collagen, hydrokeratin, wheat germ protein, silk protein hydrolysate, hydrolyzed conchiolin protein, whey protein, urea, polysaccharides, for example from sugar beet, phytosterols, amino acids or squalane can also be used as active substance which promotes the moisturizing capacity of the skin.As a third active ingredient in the cosmetic and / or dermatological formulation, an antiseptically active compound, an antiseptically active extract or oil is used. Zinc oxide is preferably used because of its astringent and antiseptic action. Owing to the controlled release of active substance of the silver ions, the zinc oxide only needs to be introduced into the formulation in very small doses. The content of zinc oxide can be 0.05 to 1.5 wt %, preferably 0.1 to 1.0 wt %, particularly preferably 0.1 to 0.5 wt %. Depending on the setting of the average agglomerate size and the specific surface area of the metallic silver, the use of zinc oxide can optionally also be dispensed with completely. As antiseptic, a melissa, propolis, niem, chamomile, rosemary, cowpea extract or sesame oil may also be used.Conventional fatty acids, fatty alcohols, glycerides, wax esters, oil components and also deionized water, silicone oil and monohydric or polyhydric alcohols are used as further base and auxiliary substances. The most important components of the formulation are the fats and oils comprising the triglycerides and diglycerides. Customary triglycerides are the capric / caprylic triglycerides which are built up from capric acid, caprylic acid and glycerol. Both capric acid and caprylic acid belong to the medium-chain fatty acids. The longer chain fatty acids which may be present chemically bound to glycerol as glycerides include palmitic acid, stearic acid, behenic acid and linoleic acid. It is convenient to use glyceryl stearates and caprylic / capric triglycerides with a total content of 6 to 25 wt%. It is preferred to use glyceryl stearates in the range from 0.5 to 10 wt. %, in particular from 1 to 5 wt. %, and triglycerides in the range from 0.5 to 15 wt. %, preferably from 5 to 10 wt. %. Glyceryl stearates function as an oil-in-water emulsifier to adjust the viscosity of the cream. The triglyceride component caprylic / carpin triglyceride is a neutral high-spreading oil component. Hydrogenated cocoglycerides are used for adjusting the consistency and promoting penetration. The glycerides may constitute a total content of the formulation of from 1 to 25% by weight, preferably from 7 to 20% by weight.As solubilizers, monohydric and / or polyhydric alcohols can be used in the formulation. Suitable polyhydric alcohols are derivatives of glycol, such as ethylene glycol, propylene glycol, butylene glycol and also glycerol. The solubilizing agent is preferably contained in the formulation in an amount of up to 15% by weight. The pure glycols are present in the finished formulation at 3 to 15 wt %, preferably at 5 to 10 wt %.As further bases and auxiliaries, polar oils having an average spreading capacity, which are used for skin oils or also for low-fat emulsions, are used. A typical polar oil having good spreading ability is decyl oleate. The longer chain fatty acids, as well as the derivatized longer chain fatty acids, are typically used as an emollient or oil-in-water emulsifier. Typical representatives are isostearyl isostearates, glyceryl stearates, methylglucose sesquistearates. The total content of stearates in the final formulation may be 1 to 25 wt.%, the individual contents being between 0.5 and 10 wt.%, preferably between 1.0 and 5.0 wt.%.Fatty alcohols, such as cetearyl alcohol or stearyl alcohol, are used as consistency regulators for oil-in-water systems. Octyldodecanol is used as an emollient and as a glide rail for lipid-soluble active ingredients. The fatty alcohols can be present in the formulation at 0.5 to 15% by weight and the individual components at 0.5 to 10.0% by weight, preferably at 1.0 to 5.0% by weight.The wax component used is jojoba oil (Simmondsia Chinensis), which preferably makes up 0.5 to 10 wt %, in particular 1 to 5 wt %, of the formulation. The total content of the wax esters can be 1.0 to 15.0 wt %, the individual wax esters occurring at 1.0 to 10 wt %, preferably at 1.0 to 5.0 wt %, in the formulation. The watchdog esters also include decyl oleate.As a spreading agent, which at the same time has a water-repellent, skin-smoothing effect and forms a non-occlusive protective film, a silicone oil, in particular dimethicone, can be used in the formulation. The silicone oil is used in the formulation in the range from 0.05 to at most 1.5% by weight, preferably 0.1 to 1.0% by weight.Further auxiliaries are, for example, complexing agents which can inactivate radicalizing heavy metals. These include, inter alia, ethylenediaminetetraacetic acid sodium salt (disodium EDTA) and fruit acids, in particular citric acid. The fruit acids, in particular citric acid, also serve to adjust the pH. The complexing agents or the compound for adjusting the pH value can make up a total content of 0.05 to 2% by weight.The total content of all active ingredients present in the formulation according to the invention may be from 0.03 to 11% by weight, with low contents of from 0.1 to 10% by weight being preferred. Particularly preferably, the active compound combination is panthenol, zinc oxide and silver, wherein the panthenol makes up 1.0 to 5 wt %, the zinc oxide 0.05 to 1 wt % and the silver 0.05 to 1.5, preferably 0.1 to 1 wt %, of the total formulation. The remaining portion of the formulation to 100% by weight is made up by water, in particular distilled water. Typically, these are 45 to 80 wt% of the total formulation.A composition according to the invention preferably contains by weightWater 50.0 to 75.0 wt.%Butylene glycol 5.0 to 10.0 wt%Caprylic / capric triglycerides 5.0 to 10.0 wt.%Isostearyl isostearates 1.0 to 5.0% by weightMethyl Glucose Sesquistearate 1.0 to 5.0 wt%Cetearyl alcohol 1.0 to 5.0% by weightHydrogenated cocoglycerides 1.0 to 5.0% by weightJojoba oil (Simmondsia chinensisger oil) 1.0 to 5.0 wt%Decyl oleate 1.0 to 5.0% by weightOctyldodecanol 1.0 to 5.0% by weightGlyceryl stearates 1.0 to 5.0 wt.%Citric acid 0.1 to 1.0 wt%Disodium EDTA <1.0 wt.%active ingredientsPanthenol 1.0 to 5 wt %Silver 0.1 to 1.0 wt%Zinc oxide 0.1 to 1.0 wt%.In addition, the composition according to the invention may comprise constituents as are customarily used in the cosmetic industry. Depending on the intended use, it may also be of interest to add UV filters, vitamins, plant extracts, algal extracts or amino acids and peptides to the composition.The formulation according to the invention is based on the preparation of a premix which is stirred into a base formulation. The premix is prepared by homogenizing an active ingredient which promotes the moisturizing ability of the skin and colloidal and / or highly porous silver. It is essential that the homogenization of the premix is carried out below 50° C., preferably below 40° C.In the preparation of the base formulation for the formulation according to the invention, the following process steps are carried out successively a) mixing of water, a glycol and a complexing agent at 60 to 80° C., preferably the water is introduced at about 60° C. The glycol and the complexing agent are added and the mixture is heated further to 75 to 80° C.; in step b), at least one glyceride, stearate or stearate derivative, fatty alcohol, oil or wax ester and silicone oil is mixed at 60 to 85° C., the components being heated to 60 to 85° C., preferably to 75 to 80° C., with stirring starting from room temperature; c) the mixtures of a) and b) are mixed, the mixture of a) being stirred to the mixture of b) at a maintained temperature. The mixture is stirred for about 10 minutes before cooling of the mixture can be started. In step d) of the process for preparing the base formulation, a mixture of water and a fruit acid is added to the mixture from step c). As fruit acid, citric acid, or any other fruit acid, is particularly suitable for adjusting the pH. To produce the formulation according to the invention, the premix is mixed below 50° C., in particular below 40° C., with further formulation components, in particular the base formulation, the premix being stirred into the base formulation or into the further formulation components. The mixture is then cooled to room temperature with stirring.The cosmetic and / or dermatological formulation according to the invention, which contains colloidal and / or highly porous silver, is particularly well suited for the care, sedative, prophylactic treatment and / or for the treatment of strained, cracked, reddened and / or pruritic skin, for the support of wound healing, as antiseptic, for the antimicrobial and / or antifungal treatment of the skin and / or in neurodermitis. The formulation according to the invention is particularly suitable for the treatment of the skin in neurodermitis because it contains active ingredients which promote the moisturizing capacity of the skin and colloidal and / or highly porous silver which releases silver ions in a retarded manner over a long-lasting period of time and prevents growth of germs on the cracked skin. At the same time, the use of preservatives can be dispensed with in the formulation.The invention is illustrated in more detail by the following examples.Example 1:1,3.Butanediol (butylene glycol)5,00 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgEDTA0,05 kg kg kg kg kg kg kg kg kg kg kg kg kg kg 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kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgDI water3,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgPart D:MicroSil BG® Panthenol Paste2,10 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgPart D consists of 90% of dexpanthenol 75% pure and 10% of MicroSil BG®.Example 4: Example 4:1,3.Butanediol (butylene glycol)5,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgEDTA0,05 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgPart B:Myritol 3184,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgCetiol V2,25 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgJojoba oil golden yellow2,25 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgPrisorine 20394,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgEutanol G2,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgTegocare PS3,75 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgLanette O3,25 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgCutina MD2,20 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgSoftisan 1003,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgDow Corning 2000,30 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgPart C:Citric acid0,40 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgDI water3,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgPart D:MicroSil BG® Panthenol Paste, Zinc Oxide7,50 kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kg kgPart D consists of 71.5% of dexpanthenol 75% strength and 14.25% of MicroSil BG® and 14.25% of zinc oxide.Example 4: The pre-formulations of Examples 1 to 3 can be incorporated in concentrations of 0.01 to 50% by weight and preferably 2 to 4, in particular 3.5% by weight, into a large number of cosmetic or dermatological formulations, for example in shampoos, masks, gels, conditioners, moisture dispensers or tinctures.The formulation according to Example 2 was tested on 20 subjects of age 18 to 71 years suffering from mild to moderate neurodermitis over a period of four weeks. The formulation was applied neat in the epicutaneous test. The aim of the investigation was to investigate the formulation for its compatibility according to clinical dermatological test criteria. The participants and participants in the test group did not have any other skin changes requiring treatment. The formulation was applied to skin areas with slight to medium eczematous changes at least once daily.At the end of the four week test period, a final epicutaneous test was performed to preclude sensitization from developing in one of the subjects during the application period. During the application test, all subjects applied the formulation very well. No pathological changes in skin occurred and no disruption of the test or treatment by the skin of the medical professional was necessary in any of the cases.At the end of the four week application test, no additional pathological changes in skin were found. Firstly, the skin reaction during application was tested and also the skin reaction after application. The second criterion used was subjective assessment by the test persons who included assessment of the preparation as a whole and subjective feeling of skin after application of the preparation.The formulation according to the invention was evaluated as follows:The pull-in behavior was perceived as very good and fast by 100% of the test subjects. The cooling by the product was classified as "very good" in terms of pleasantness by 95% of the test subjects. The dispersibility of the formulation was also evaluated as very good by 95% of the test subjects. 85% of the neurodegenerative agents have considered the product to be non-greasy with the rating "very good". It was said that itch relief and delusion relief were very good from 80% of the subjects. 80% of the subjects evaluated the relaxation of the skin by the product as very good. The moisture-donating capacity was reported as "very good" from 90% of the subjects. It was stated from 85% of the test subjects that very good skin comfort takes place as a result of the formulation. Another 90% of the subjects received the cream as very good help with dry skin 80% of the subjects looked for the product as very well suited for daily care. And consistency was also indicated to be good, pleasant, light from 80% of the subjects.Overall, 90% of the neurodegenerative agents keep the formulation very well suited to sensitive skin. Moreover, the product left a pleasant feeling on the skin at 90% of the neurodegenerative agents.The formulation according to the invention was used at the predictive sites such as elbows, knee fillets, hands and face. All subjects had fallen the preparation well to very well. Only 15% of the test subjects were deficient in the cream color, but they would not be prevented from purchasing the cream.The epicutaneous tests were performed according to the International Contact Dermatitis Research Group (ICDRG) International Guidelines after the completion of the four week period of use, ensuring that none of the 20 subjects were sensitized by the formulation during the application test. In the epicutaneous tests, no changes in skin in the test zone could be detected in any of the 20 test subjects after 24, 48 and 72 hours. It follows that in the test subjects, the product will not lead to undesired skin reactions through skin irritant or sensitizing effects in practical use.

Claims

Cosmetic and / or dermatological formulation comprising cosmetic and / or dermatological active ingredients, and also auxiliaries and base substances, wherein metallic silver and an active ingredient which improves and / or increases the water-binding capacity of the skin are present as active ingredients, characterized in that the silver is present in porous form, wherein the specific surface area of the porous silver is in the range from 2 to 6 m 2 / g, measured by the N 2- adsorption by BET volumetrically.Formulation according to claim 1, characterized in that the active ingredient which improves and / or increases the water-binding capacity of the skin comprises dexpanthenol, pantothenic acid, panthenyl-ethyl ether, panthenyl-ethyl ether acetate, panthenyl-triaceate, allantonin, hyaluronic acid, an algal extract, native collagen, hydrokeratin, wheat germ protein, silk protein hydrolysate, hydrolyzed conchiolin protein, whey protein, urea, a polysaccharide or a phytosterol.Formulation according to either of Claims 1 and 2, characterized in that the further cosmetic and / or dermatological active ingredient present is an antiseptic active ingredient.Formulation according to one of Claims 1 to 3, characterized in that it comprises, as further auxiliaries, at least one fatty acid, fatty alcohol, glyceride, wax ester, water, silicone oil, monohydric alcohol and / or polyhydric alcohol.Formulation according to any one of claims 1 to 4, characterized in that ethylene glycol, propylene glycol, butylene glycol and / or glycerol are contained as polyhydric alcohols in an amount up to 15 wt.%.Formulation according to any one of claims 1 to 5, characterised in that it comprises 45 to 80 % by weight of water, - 3 to 15 % by weight of at least one glycol, - 0.5 to 15 % by weight of at least one glyceride, the total content of glycerides being 6 to 25 % by weight, - 0.5 to 10 % by weight of at least one stearate, the total content of stearates being 1 to 25 % by weight, - 0.5 to 10 % by weight of fatty alcohols, the total content of fatty alcohols being 1 to 15 % by weight, - 0.5 to 10 % by weight of at least one wax ester, the total content of wax esters being 1 to 25 % by weight, - 0.05 to 1.5 % by weight of a silicone oil, 0.1 to 10% by weight of active compound, the total content of active compounds being 0.3 to 11% by weight, and 0.05 to 2.0% by weight of at least one complexing agent or a compound for adjusting the pH, the total content of these components being ≤2% by weight.Formulation according to any of Claims 1 to 6, characterized in that it comprises from 0.05 to 1.5% by weight of metallic silver.A method for preparing a cosmetic and / or dermatological formulation according to any one of the preceding claims, comprising the following steps: a) preparing a premix by homogenizing an active ingredient which improves and increases the water-binding capacity of the skin and porous silver, wherein the specific surface area of the porous silver is in the range of 2 to 6 m 2 / g, measured by the N 2- adsorption according to BET volumetrically, wherein the active ingredient which improves and increases the water-binding capacity of the skin comprises dexpanthenol, pantothenic acid, panthenyl-ehyl ether, panthenyl-ethyl ether acetate, panthenyl-triaceate, a further panthenol analogue, allantonin, hyaluronic acid, an algae extract, native collagen, A hydrokeratin, wheat germ protein, silk protein hydrolysate, hydrolysed conchiolin protein, whey protein, urea, a polysaccharide or a phytosterol, and b) agitating the premix into a base formulation.The method of claim 8, wherein in preparing the premix, the active agent, silver, and an antiseptic active agent are homogenized.Method according to claim 8 or 9, characterised in that homogenization is effected below 50°C.Method according to one of Claims 8 to 10, characterized in that, in order to produce the basic formulation for the cosmetic and / or dermatological formulation, the following process steps are carried out: a) mixing water, a glycol and a complexing agent at 60 to 80°C, b) mixing at least one glyceride, stearate, fatty alcohol, oil and silicone oil at 60 to 85°C, c) mixing the mixtures of a) and b), d) adding a mixture of water and a fruit acid to the mixture of c).Process for preparing a formulation according to any of Claims 8 to 11, characterized in that the premix is mixed below 50°C with further formulation components and / or the base formulation.Use of a cosmetic and / or dermatological formulation according to any of Claims 1 to 7 for the care, sedative, prophylactic treatment and / or for the treatment of strained, cracked, reddened and / or pruritic skin, for assisting wound healing, as antiseptic, for antimicrobial and / or antifungal treatment of the skin and / or in neurodermitis.