Composition for use in the treatment of caries and / or gingivitis
The double-emulsion technique using PLGA matrix encapsulation with alkali salts provides a controlled release of flavonoids, addressing rapid release issues in existing methods, achieving sustained efficacy against oral pathogens.
DE102024134253A1Pending Publication Date: 2026-06-03ALBERT LUDWIGS UNIV FREIBURG +1
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Applications
- Current Assignee / Owner
- ALBERT LUDWIGS UNIV FREIBURG
- Filing Date
- 2024-11-21
- Publication Date
- 2026-06-03
Smart Images
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Abstract
The invention relates to a process for producing microparticles loaded with at least one flavonoid and / or flavonoid derivative, comprising the following successive steps: a) Mixing a water component in the form of an aqueous solution comprising the at least one flavonoid and / or flavonoid derivative with an oil component to form a solution of polylactide-co-glycolide in an organic solvent, to form a water-oil emulsion; b) Mixing the water-oil emulsion from step a) with another water component in the form of an aqueous solution comprising at least one stabilizer, to form a water-oil-water emulsion, c) Mixing the water-oil-water emulsion with an aqueous salt solution; d) Removal of the organic solvent in the water-oil-water emulsion to form a suspension comprising the microparticles loaded with at least the flavonoid and / or flavonoid derivative; e) Separating the loaded microparticles from the liquid of the suspension. Furthermore, the invention relates to microparticles, the use of which for the manufacture of a medicinal product, a dispersion containing the microparticles for use in the treatment and / or prophylaxis of oral infections, as well as non-medical use in cosmetics.
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