HAIR GROWTH PREPARATION CONTAINING L-CYSTEINE

Description

[0001] The present invention relates to a hair growth preparation which is not intended for external application on the scalp, but for oral administration.

[0002] There are hair growth preparations for oral administration that take up the basic idea that an improved supply of the organism and metabolism with the necessary acids, vitamins, minerals, trace elements, etc. can have a positive influence on hair growth.

[0003] For example, Priorin®, a hair growth supplement containing L-cysteine, a sulfur-containing proteinogenic amino acid, as well as a complete extract of millet berries and calcium pantothenate, has been on the market for some time. The disadvantage of this hair growth supplement, however, is that it only covers a very narrow spectrum of the necessary substances, all of which can contribute to healthy hair growth. Furthermore, the composition is too unspecifically tailored to individual requirements.

[0004] Another hair growth supplement, also developed for oral administration, is amitamin® Hair Plus. This hair growth supplement aims to cover a broader spectrum of necessary and beneficial substances by containing yeast, biotin, vitamin E, amino acids, iron, zinc, and others in addition to the substances already mentioned. However, this supplement is also not customized.

[0005] In general, it is a disadvantage, especially from the perspective of a cost-effectiveness-success ratio, when undifferentiated "all-round sledgehammers" are thrown onto the market, which to a high degree do not work, and if they do work, do so more by chance.

[0006] The lack of differentiation of such "ex-factory" hair growth preparations, in the form of standard or mono-preparations, represents a disadvantage not only with regard to the availability of the optimally required – potentially quite expensive – substances or substance combinations, but also with regard to their dosage. These are kept at a level that is generally acceptable and accordingly low, even though the customer would be particularly dependent on a specific substance or substance combination in a relatively higher dose compared to the remaining substances or substance combinations.

[0007] Hair growth products containing hormonally active substances or combinations of substances are also disadvantageous. For example, once you start taking the active ingredient finasteride from the drug Propecia ®, you must continue taking it for life. Otherwise, the situation will worsen beyond the initial stage. Furthermore, this hair growth product is not suitable for women and interferes with the hormonal balance, causing significant negative side effects by suppressing dihydrotestosterone (DHT) levels over the long term.

[0008] There is also Pantostin with the active ingredient alfastradiol, which attempts to counteract the regression of hair roots not through hormones, but rather through medication or chemicals.

[0009] Pantovigar N is also taken orally and uses B vitamins and cysteine ​​to improve nutrient supply so that the formation of hair keratin is promoted.

[0010] Furthermore, there are capsules developed by Oxford Biolabs and marketed under the name TRX2 ®, a patent-pending treatment for alopecia. This patent, not yet published at the time of writing, describes a combination of powerful metabolic stimulants (potassium, nicotinic acid, and BCAAs (branched-chain amino acids, i.e., valine, leucine, and isoleucine) with a natural energy-boosting substance (Carnipur ™ tartrate). This combination is intended to stop hair loss and promote hair growth at the molecular level. However, this product is not individually tailored to the customer.

[0011] US patent 6,149,933, granted on November 21, 2000, discloses a dietary supplement for promoting healthy hair and restoring pigment. It does not claim to be a hair growth preparation with therapeutic effects, but rather a dietary supplement intended to counteract graying. The described dietary supplement essentially contains a copper salt, para-aminobenzoic acid or salts thereof, pantothenic acid or salts thereof, and vitamin B6. It does not contain L-cysteine, zinc, silicon, or cholecalciferol or vitamin D3.

[0012] The international publication WO 2005 / 079857 A1 dated 01.09.2005 describes a method for increasing nutrient bioavailability by using polysaccharides such as galactomannans, glucomannans and the like to introduce active substances such as the human growth hormone HGH into the human or animal metabolism.

[0013] A dietary supplement called "Condition Specific Nutrition For Hair, Skin & Nails," distributed by Wellness & Nutrition India in 2009, claims to be important for skin, hair, and nails due to its zinc, vitamin E, and omega 3. The supplement may contain other nutrients, but does not disclose silicon, cholecalciferol, or vitamin D3, nor does it offer "customization" to a customer's precise and determined nutritional needs.

[0014] Another dietary supplement, "Hair Fitness ®< Nutritional Supplement," promises thick, silky, and youthful-looking hair, but also does not contain silicon, cholecalciferol, or vitamin D3, and does not provide for individually adjusted daily doses.

[0015] The object of the present invention is to provide a hair growth preparation, while avoiding the disadvantages outlined above, which has a further improved basic composition and can be varied and / or adapted to the individual needs of a customer and is generally optimized in its properties and application.

[0016] The scope of protection of the patent is defined by the appended claims. The solution to the problem lies, first, in the inventive composition of a hair growth preparation in a basic variant, which comprises the following basic substances or basic substance compositions: L-cysteine ​​zinc copper calcium magnesium silicon vitamin D3.

[0017] As mentioned at the beginning, L-cysteine ​​is a sulfur-containing proteinogenic amino acid and a building block of hair keratin, making it an important structural element for hair and nails. Thanks to its sulfur content, L-cysteine ​​can bind heavy metal ions, which can in turn cause hair loss. Together with other amino acids (glutamine, glycine), L-cysteine ​​is involved in the synthesis of glutathione, one of the most important antioxidants in the human body and beneficial for the utilization of vitamins C and E. Glutathione also inhibits inflammatory reactions and stimulates the production of white blood cells and leukotrienes. The human liver can synthesize its own L-cysteine, but it must also be ingested through food, with a daily requirement of approximately 1,400 mg.This requirement is often unmet because certain conditions, such as cataracts, arthritis, or other chronic diseases, as well as diets, stress, or physical exertion, increase it. Further complicating the situation is the fact that preparation methods that involve prolonged immersion or boiling of foods leach out the highly water-soluble L-cysteine.

[0018] The trace element zinc, on the other hand, plays a key role in cell division in the human body, i.e., general growth and cell and skin regeneration, insulin storage, protein synthesis, sperm production, and the immune system. Zinc is generally involved in hormone metabolism, has a positive effect on the central nervous system during stress, regulates acid-base balance, and helps eliminate heavy metals. A zinc deficiency can lead to, among other things, increased hair loss, poor skin prone to inflammation, and a weakened immune system. Zinc deficiency is particularly problematic in vegetarian diets, as zinc is primarily found in meat, cheese, milk, and eggs. The zinc contained in grain products is less easily absorbed from the intestines in a protein-poor diet. When administering zinc, it must be noted that intestinal zinc absorption is impaired if iron supplements are administered at the same time.

[0019] The above-described basic composition of a hair growth preparation according to the invention also includes copper. The trace element copper is involved in the formation of collagen and thus ensures the tightening of skin, connective tissue, nerve tissue, and blood vessels. Furthermore, the trace element copper is involved in the formation of melanin, the pigment of hair, skin, and eyes. Gray hair can be caused by a copper deficiency. Furthermore, copper plays a key role in the production of the body's own antioxidants, which slow down the aging process.

[0020] Calcium, on the other hand, is no longer a trace element for the human body, but a macronutrient, meaning it contains more than 50 mg per kg of body weight. With a body content of 1-1.1 kg, calcium is the most abundant mineral in the human organism. 99% of this is found in bones and teeth, but calcium also plays a key role in the body's stimulation of muscles and nerves, glycogen and amino acid metabolism, cell division, and the activation of certain enzymes and hormones. The recommended daily intake for an adult male is roughly 1,000 mg. It should be noted that a protein-rich diet, in particular, increases the need for calcium.

[0021] Furthermore, magnesium is considered an essential substance because it is indispensable for all organisms. It must be supplied to the body daily in sufficient quantities (approximately 300 mg) through food and drinking water, and absorption occurs in the upper small intestine. The body of an adult contains approximately 20 g of magnesium, which is involved in approximately 300 enzyme reactions as an enzyme component or coenzyme. Furthermore, free magnesium ions influence the potential at cell membranes and function as second messengers in the immune system. They stabilize the resting potential of excitable muscle and nerve cells and the cells of the autonomic nervous system. Magnesium is a muscle and connective tissue relaxant.Magnesium deficiency causes restlessness, nervousness, irritability, headaches, lack of concentration, fatigue, general weakness, cardiac arrhythmia, muscle cramps and, of course, a general lack of nutrients that can impair hair growth.

[0022] Silicon is a major element in bone-forming cells, but also an important structural element for cartilage, connective and bone tissue, skin, hair, and fingernails. Low hair silicon levels have been observed in cases of hair loss. Chronic exposure to aluminum appears to impair silicon bioavailability.

[0023] Vitamin D3, or cholecalciferol, is required in the human body, among other things, to absorb larger amounts of calcium. It forms a protein carrier that ensures the transport of calcium through the intestinal wall. Vitamin D3 is the only vitamin whose biologically active form is a hormone that has a broad function in the body. It is involved, among other things, in the formation of bones and teeth, but also in the immune system by supporting the function of white blood cells to fight infections. Due to the endemic lack of light in modern societies, the body's own synthesis of vitamin D3 in the skin is insufficient. Consequently, the German Nutrition Society (DGE) has set a guideline value of 20 µg of vitamin D3 for an adult, which should be covered through food.What makes things even more difficult is that not only sunscreens, but almost all day creams today contain UV-B and UV-A filters.

[0024] The dosage of these basic substances or basic substance compositions can be varied and adapted to the individual organic nutrient supply requirements of the customer, depending on the results of individual tests and measurements, but also depending on the evaluation results of questionnaires.

[0025] The present invention is based on the following basic ideas: Certainly, a person's head hair can be assigned certain bodily functions or an organic "purpose," but these are not vital to the organism. For example, in the event of a death threat from frostbite, the blood supply to the extremities or organs less important for the organism's vital functions is gradually cut off, and only last of all is the blood supply to the heart and brain. The organism copes with a persistent nutrient deficiency in a similar way, prioritizing the available nutrients first to the vital organs and body parts, with hair growth being given a lower or even last priority.

[0026] A second basic idea is that hair loss per se is less genetically inherited, but rather lifestyle habits and the ability to better or worse absorb, assimilate, or utilize certain nutrients. Furthermore, an adaptable hair growth product according to the invention is based on the knowledge that approximately 80% of men are affected by hair loss, while only approximately 38% of women are. Therefore, it is necessary to adapt the hair growth product, at least with regard to gender, to the different requirements of both sexes, and even better, to other individual requirements.

[0027] Furthermore, a hair growth preparation according to the invention is based on the knowledge that the vitamin and nutrient content of food in our latitudes has decreased by approximately 30% and that, at the same time, more stressful and hectic lifestyles require an increased intake of vital substances such as vitamins, trace elements, minerals, amino acids and quasi-vitamins.

[0028] A hair growth preparation according to the invention is also based on findings from orthomolecular medicine. According to this principle, optimal metabolism in the organism only occurs when a high number of different vital substances is ensured in different and coordinated dosages. Even a single deficiency among the more than two dozen required micronutrients can slow or even block the entire metabolism. Accordingly, the composition of a hair growth preparation according to the invention is not limited to individual substances or combinations of substances and the usually cautiously recommended minimum dosages, but preferably includes many or all of the substances required by the body, and some or the others readily in very high dosages.

[0029] A further embodiment of a hair growth preparation according to the invention comprises, in addition to the basic substances or basic substance compositions listed in paragraph

[0016] , vitamin E. Vitamin E is a collective term for lipid-soluble substances with antioxidant effects, which most frequently occur in the form of tocopherols and tocotrienols. Vitamin E helps the immune system to eliminate oxidative influences from the environment and toxic substances, and to destroy bacteria. It has also been observed that the need for vitamin E increases with a diet containing a high number of polyunsaturated fatty acids. The composition of a hair growth preparation according to the invention can include vitamin E not least because it has been recognized that vitamin E promotes blood circulation in the scalp and thus strengthens the anchoring of the hair. Furthermore, vitamin E is required for the synthesis of various nutrients important for the hair.

[0030] Furthermore, a further embodiment of a hair growth preparation according to the invention comprises, in addition to the basic substances or basic substance compositions listed in paragraph

[0016] and / or in paragraphs

[0016] and

[0029] , vitamin C or ascorbic acid. This is based on the findings that vitamin C helps with detoxification, e.g., from heavy metals that cause hair loss, is an effective antioxidant ("radical scavenger"), acts as a stress reliever, and thus makes more nutrients available for hair growth. Furthermore, vitamin C plays a key role in collagen production and also improves hair structure.

[0031] A further embodiment of a hair growth preparation according to the invention comprises, in addition to the previously disclosed basic substances or basic substance compositions, biotin, vitamin H, or vitamin B7. This is based on the finding that biotin plays a key role in metabolic activation and cell growth, and that a deficiency can lead, among other things, to increased hair loss.

[0032] Another composition variant of a hair growth preparation according to the invention also includes L-methionine, an essential proteinogenic amino acid that, like L-cysteine, also contains sulfur, and from which L-cysteine ​​is formed. L-methionine plays a key role in the formation of procollagen and is therefore important for hair formation.

[0033] A further preferred composition variant of a hair growth preparation according to the invention also includes pantothenic acid, also known as vitamin B5. It is the water-soluble vitamin from the B vitamin series and is involved in the synthesis and breakdown of carbohydrates, fats, amino acids, and cholesterol, which in turn is needed for the formation of steroid hormones. A deficiency can lead to fatigue, insomnia, depression, numb and aching muscles, anemia, immune deficiency, and stomach pain, thus resulting in such a poor general condition that hair growth is deprived of the necessary nutrient supply.

[0034] A further preferred embodiment of a hair growth preparation according to the invention comprises, in addition to the disclosed basic substances or the basic substances plus one or a combination of the optional substances, or plus all optional substances, also iron. Iron is an essential trace element that plays a key role in blood formation and oxygen transport, oxygen storage, and electron transfer. Furthermore, iron is a component of iron-sulfur complexes in many enzymes. It has been recognized that iron deficiency is not only common in women due to menstruation and childbirth or in athletes, but that an undersupply generally exists. When composing a hair growth preparation according to the invention with iron, care is taken to ensure that simultaneous intake of vitamin C significantly increases the absorption rate of iron, whereas dairy products, coffee, or black tea inhibit it.

[0035] A further preferred embodiment of a hair growth preparation according to the invention comprises, in addition to the disclosed basic substances or the basic substances plus one or a combination of the optional substances, or plus all optional substances, vitamin B6 or the three precursors of the activated vitamin pyridoxal phosphate, namely pyridoxine, pyridoxal, and pyridoxamine. Vitamin B6 is essential for amino acid metabolism and acts as a coenzyme in approximately 100 enzymatic reactions. Vitamin B6 deficiency symptoms manifest themselves in loss of appetite, diarrhea, vomiting, dermatitis, growth disorders, anemia, nerve degeneration, seizures at irregular intervals, and anxiety disorders. The requirement for vitamin B6 is directly proportional to protein intake and is recommended by the German Nutrition Society (DGE) as a daily dose of 1.6 mg for women and 1.8 mg for men.

[0036] A further preferred embodiment of a hair growth preparation according to the invention comprises, in addition to the disclosed basic substances or the basic substances plus one or plus a combination of the optional substances or plus all optional substances, also vitamin B12 or cobalamin, named after its central atom, cobalt. Vitamin B12 is important in the human organism for cell division and blood formation, as well as the function of the nervous system. The human organism is not able to produce vitamin B12 itself and must therefore obtain it through food. This is primarily ensured through the consumption of meat and offal, and in vegetarian diets must be increasingly obtained through the consumption of dairy products and eggs or nori seaweed. A vitamin B12 deficiency can lead to blood disorders and myelitis, an inflammation of the spinal or bone marrow.In recent years, there has also been increasing evidence of a possible connection between vitamin B12 deficiency and other illnesses such as dementia and neuropathies. Low vitamin B12 blood serum concentrations are generally more common in older people. The first signs of vitamin B12 deficiency in adults can include tingling and coldness in the hands and feet, exhaustion and weakness, difficulty concentrating, and even psychosis. The minimum daily requirement for an adult is approximately 3.0 µg, and for pregnant and breastfeeding women, 3.5–4.0 µg.

[0037] A further preferred embodiment of a hair growth preparation according to the invention comprises, in addition to the disclosed basic substances or the basic substances plus one or a combination of the optional substances or plus all optional substances, also selenium. Selenium is an essential trace element for all life forms, which, among other things, protects cell membranes from oxidative damage due to its high reactivity with oxygen. Furthermore, selenium and its compounds play an important role in the production of thyroid hormones. However, a positive effect from selenium administration can only be observed in a very narrow and precise dosage range. There are studies that support the suspicion that type 2 diabetes can be caused by an administration of 200 µg of selenium per day. And employees in the electronics, glass, and paint industries who are exposed to daily doses of more than 400 µg, among other things,Symptoms of poisoning include nausea and vomiting, nail changes, peripheral neuropathy, exhaustion and, of all things, hair loss.

[0038] Another composition variant of a hair growth preparation according to the invention also includes niacin, or nicotinic acid, which is another vitamin from the B complex. It is a crystalline solid found in all living cells and stored in the liver. It is central to the metabolism of proteins, fats, and carbohydrates and is important for the regeneration of skin, muscles, nerves, and DNA. It is also said to improve blood circulation in the scalp and, based on the average energy requirement of an adult body, is needed in an amount of 6.6 mg to generate an energy amount of 1,000 kilocalories for its cells, tissues, and organs. This means that the requirement for women is 13 to 15 mg per day and for men 15 to 20 mg per day.

[0039] A further embodiment of a hair growth preparation according to the invention comprises, in addition to the basic substances or optional substances described above, folic acid, which is also known by the trivial name vitamin B9 and is another light-sensitive vitamin from the B complex. Folic acid is involved in the synthesis of DNA building blocks and plays a crucial role in cell division. It is essential for the human organism and cannot be produced by the body itself. A folic acid deficiency can lead to, among other things, anemia and promotes the development of neural tube defects such as spina bifida or anencephaly during embryonic development. The recommended daily dose according to the RDA (Recommended Daily Allowance) or the DA-CH reference values ​​for nutrient intake is 200 µg. In some countries, such as Switzerland, mandatory admixture is stipulated by law.

[0040] A further preferred composition variant of a hair growth preparation according to the invention comprises, in addition to the basic substances or any combination of the basic substances with the optional substances, coenzyme Q10, also known as ubiquinone-10. It is a quinone derivative, structurally related to vitamin K and vitamin E, and a substance naturally present in the body, which is partially absorbed through food but also produced in the body itself. Q10 is essential in the conversion of energy from food into endogenous energy (ATP) in every human cell. Q10 is an essential cofactor of the respiratory chain in the mitochondria of the cell and also serves as the most important lipophilic antioxidant, acting as a free radical scavenger during stress and degenerative processes.A permanent Q10 deficiency is rare, but to avoid or compensate for a deficiency, most scientists recommend a daily dose of 30-200 mg per day.

[0041] A further preferred composition variant of a hair growth preparation according to the invention comprises, in addition to the basic substances or any combination of the basic substances with the optional substances, also omega-3 fatty acids. These are essential substances for the human diet and cannot be produced by the body itself. They are said to reduce cardiovascular risks, prevent cancer, inhibit inflammation, and prevent age-related degenerative diseases and dementia, among other things. The European Food Safety Authority (EFSA) and the German Nutrition Society (DGE) recommend a daily dietary intake of 250 mg for the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in particular. The omega-3 fatty acids are preferably added using microcapsules, which are preferably powdered or in a powder form.Consistency of a hair growth preparation according to the invention and which contain the omega-3 fatty acids.

[0042] A preferred composition of a hair growth preparation according to the invention further comprises guar gum, to which the disclosed substances and substance compositions are bound. Guar gum is produced from the seeds of the guar bean and consists predominantly of long-chain carbohydrates, which are characteristically composed of the simple sugars mannose and galactose. These long-chain compounds can bind very large amounts of water. This, and the slimy consistency, are presumably the reason for the observation that the substances and substance compositions of a hair growth preparation according to the invention are transported significantly better into the small intestine. In contrast to the stomach or duodenum, the absorption of the substances and substance compositions in the small intestine is almost 100% higher, without any undesirable interactions.In addition, guar gum has the positive side effect of being a soothing intestinal tract moisturizer. According to the invention, guar gum thus acts as a retarder, allowing nutrient absorption to occur where it is most effective.

[0043] In the event of any allergic reactions to guar gum, locust bean gum is preferably used in the composition of a preferred hair growth preparation according to the invention described above.

[0044] From all these findings and inventive considerations, an optional and exemplary complete variant of a hair growth preparation according to the invention results, for example for an adult human being with the following exemplary, not necessarily cumulative substances or substance compositions and with the following also exemplary preferred daily doses and daily dose ranges: nutrient Preferred daily dose Daily dose range Vitamins Biotin 5.0 mg 0.1-40.0 mg Folic acid 200.0 µg 100.0-2'000.0 µg Natural carotenoids 8.0 mg 1.0-160.15 mg of which alpha-carotene 70.0 µg 1.0-100'000.0 µg of which cryptoxanthin 15.0 µg 1.0-50.0 µg of which lutein 6.0 mg 1.0-15.0 mg of which beta-carotene 1.9 mg 1.0-45.0 mg of which zeaxanthin 15.0 µg 1. 0-100.0 µg Natural vitamin E 300.0 mg 1.0-1,000.0 mg of which alpha-tocopherol 262.0 mg 85-95% of which gamma-tocopherol 30.0 mg 5-15% niacin 50.0 mg 1.0-500.0 mg Pantothenic acid 10.0 mg 1.0-1,000.0 mg Vitamin A (retinoids) 1.0 mg 1,000-40,000 IU Vitamin B1 (thiamine) 5.0 mg 1.0-200.0 mg Vitamin B2 (riboflavin) 5.0 mg 1.0-100.0 mg Vitamin B6 10.0 mg 1.0-480.0 mg Vitamin B12 35.0 µg 1.0-1'000.0 µg Vitamin C 1,500.0 mg 1.0-10,000.0 mg Vitamin D3 7 µg 1.0-100.0 µg Trace elements chrome 50.0 µg 1.0-300.0 µg iron 2.5 mg 1.0-100.0 mg iodine 50.0 µg 1.0-1'000.0 µg copper 2.0 mg 0.1-5.0 mg manganese 5.0 mg 1.0-50.0 mg molybdenum 50.0 µg 1.0-1'000.0 µg selenium 200.0 µg 1.0-400.0 µg Vanadium 50.0 µg 1.0-200.0 µg zinc 25.0 mg 1.0-100.0 mg Minerals Calcium 800.0 mg 1.0-1,500.0 mg potassium 220.0 mg 1.0-5,000.0 mg magnesium 400.0 mg 1.0-1,500.0 mg Silicon 26.0 mg 1.0-50.0 mg Quasi-vitamins a-lipoic acid 20.0 mg 1.0-1,000.0 mg Choline 40.0 mg 1.0-10,000.0 mg Inositol 30.0 mg 1.0-3,000.0 mg L-carnitine 250.0 mg 1.0-3,000.0 mg p-Aminobenzoic acid (PABA) 10.0 mg 1.0-4,000.0 mg Coenzyme Q10 (ubiquinone-10) 100.0 mg 1.0-600.0 mg Omega-3 fatty acids 250.0 mg 100.0-600.0 mg Amino acids L-Cysteine 1,000.0 mg 1.0-2,000.0 mg L-Methionine 400.0 mg 1.0-5,000.0 mg Gamma-aminobutyric acid (GABS) 1.0 mg 0.1-5,000.0 mg Plant extracts Silymarin 150.0 mg 1.0-220.0 mg Citrus bioflavonoids 200.0 mg 1.0-400.0 mg Fiber Guar 200.0 mg 1.0-500.0 mg

[0045] Examples of tests and measurements that may be considered include blood, urine, creatinine, saliva, hair, stool, and breath tests, the latter particularly for determining the acidity or pH value of exhaled air. The variants of a hair growth preparation according to the invention described below are based, among other things, on the realization that hyperacidity in the human body is widespread and thus hinders the absorption of certain vitamins, trace elements, minerals, and amino acids.

[0046] The above-mentioned blood test preferably consists of the following individual tests: blood count, erythrocyte sedimentation rate, thyroid and kidney function parameters, serum iron, iron binding capacity, zinc and selenium from whole blood, serum and whole blood calcium, transaminases and immunoglobulin E (IgE) levels.

[0047] A questionnaire, or even just a guide for collecting customer data, could include questions about gender, height, weight, age, health status, medication use, and other eating, drinking, and lifestyle habits. Furthermore, the customer might also be asked about their hair growth preferences.

[0048] The invention provides for adjusting the basic dosage of the hair growth preparation according to the invention depending on the tests and measurements, but optionally also depending solely on the answers to the questionnaire. For example, a man is given a daily dose of 25.0 mg or even 30.0 mg of zinc, in contrast to a woman, who is given 20.0 mg of zinc. The zinc dosage is increased for men because they have a higher requirement than women due to sperm production.

[0049] Furthermore, a woman may be prescribed a daily dose of 3.0 mg gamma-aminobutyric acid instead of just 1.0 mg for a man. The gamma-aminobutyric acid (GABS) is increased for women because they may suffer from premenstrual syndrome, which is alleviated by the administration of GABS. In addition, women have lower protein reserves than men, and therefore need more GABS. GABS, in combination with vitamin B6 and L-cysteine, has a positive, strengthening effect. Men, on the other hand, are often bald or partially bald and therefore have an increased need for L-cysteine, which is why they need less GABS. Those who consume alcohol more than three times a week should receive an increased dose of GABS because GABS can reduce the craving for alcohol through its calming effect on the nerves.

[0050] Furthermore, also regarding gender differences, the invention can provide only 1.0 mg of iron for a man instead of, for example, 2.5 mg for a woman. The iron intake can be reduced somewhat for men, since they don't experience iron loss through menstruation and, in their average diet, usually consume more meat than women.

[0051] Regarding body size and weight, the invention further provides for adding 13.0 mg of L-methionine per kg of body weight to the composition.

[0052] Depending on the customer's age, an age-appropriate dose of vitamin B12 is prescribed. It generally ranges from 1.0 to 1,000.0 µg, but preferably ranges from 20.0 µg to 50.0 µg, with a maximum of 35.0 µg. Furthermore, 20.0 µg is recommended for those aged 18-35, 35.0 µg for those aged 35-60, and 50.0 µg for those aged 60-99.

[0053] If hypothyroidism is present, the amount of iodine can be increased to 200.0 µg.

[0054] In the case of pre-existing cancer, the preferred amount of vitamin B6, as indicated in the table, can be increased from 10.0 mg to 25.0 mg. Furthermore, the amount of folic acid can be increased from 0.2 mg to 0.4 mg. Coenzyme Q10 can be increased from 100.0 mg to 150.0 mg, and GABS from 1.0 mg to 2.0 mg. Additionally, vitamin B12 can be increased from 35.0 µg to 50.0 µg.

[0055] In diabetes, L-cysteine ​​can be reduced from its preferred amount of 1,000.0 mg, as indicated in the table, to 400.0 mg. In addition, vitamin B1 can be increased from 5.0 mg to 50.0 mg, and vitamin B6 from 10.0 mg to 50.0 mg. Chromium can also be increased from 50.0 µg to 200.0 µg.

[0056] In case of stress, mental or physical, vitamin C can be increased from 1,500.0 mg to 2,000.0 mg and folic acid from 200.0 µg to 800.0 µg.

[0057] If a female customer exercises more than three times a week, the zinc dose can be increased from the preferred amount of 25.0 mg listed in the table to 30.0 mg. If a male customer exercises more than three times a week, the dose can be increased to 40.0 mg.

[0058] If the client consumes alcohol more than three times per week, zinc can be increased from the preferred amount of 25.0 mg to 30.0 mg, as indicated in the table, and GABS from 1.0 mg to 3.0 mg. The niacin dose can also be increased from 50.0 mg to 300.0 mg.

[0059] Regular smokers may experience a zinc deficiency due to cigarette smoke, which in turn can lead to a copper excess or even copper poisoning. Therefore, for smokers, the copper intake can be reduced from the preferred amount of 2.0 mg shown in the table to 1.0 mg. Furthermore, for smokers, vitamin C intake can be increased from 1,500.0 mg to 2,000.0 mg. Furthermore, folic acid intake can be increased from 0.2 mg to 0.4 mg, vitamin B6 from 10.0 mg to 25.0 mg, and vitamin B12 from 35.0 µg to 40.0 µg. Furthermore, the selenium intake can be increased from 200.0 µg to 250.0 µg.

[0060] A hair growth preparation according to the invention can optionally be accompanied or preceded by a deacidification of the intestinal tract or the body. Silicon, zinc, and iron can be administered simultaneously, the latter two trace elements preferably in chelated form.

[0061] If necessary, prior intestinal cleansing may be required to ensure optimal absorption of the substances and substance compositions.

[0062] In principle, however, it would also be possible to administer a hair growth preparation according to the invention intramuscularly, subcutaneously or intravenously and perhaps, with regard to certain substances, by means of depot injections.

[0063] A hair growth preparation according to the invention is preferably produced or provided in a general basic version with average dosages for women and a general basic version with average dosages for men. After evaluating the tests and measurements, as well as the questionnaires, this basic version can be supplemented with the necessary differential substances or differential dosages to create the individually tailored hair growth preparation according to the invention.

[0064] The disclosed different embodiments of a hair growth preparation according to the invention can be combined with each other as desired with regard to the optional substances.

[0065] The present application discloses a method for customizing a hair growth preparation as disclosed, comprising the following basic process steps: a) - Providing a universal version of the hair growth product with average dosages for women; b) - Providing a universal version of the hair growth product with average dosages for men; c) - Having a customer complete questionnaires; d) - If necessary, conducting tests and measurements; e) - Determining the difference substances and difference dosages based on the questionnaire evaluations and the tests and measurements; f) - Selecting the universal version of the hair growth product for women in the case of a female customer; g) - Selecting the universal version of the hair growth product for men in the case of a customer; h) - Adapting the selected version of the hair growth product to the individual customer by adding the determined difference substances and difference dosages.

[0066] A hair growth preparation according to the invention offers the following advantages, many of which have been proven by test subjects: The hair growth product is individually tailored to each client. Nutrient deficiencies are identified. It covers virtually all necessary nutrients, with peak doses for those lacking. It is well-tolerated. It improves health and well-being. Subjects feel less tired and have more energy. Hair growth is stimulated, both in terms of the number of hairs and their strength and health. Hair gains shine. Thin hair becomes fuller. Brittle hair becomes smoother. Flaky scalps become healthy again. The rate of hair growth is accelerated during the anagen phase.

[0067] Further or advantageous embodiments of a hair growth preparation according to the invention form the subject matter of the dependent claims.

[0068] The list of reference symbols is part of the disclosure.

[0069] A partial aspect of the invention is explained in more detail symbolically and by way of example with reference to a figure. It represents schematic and exemplary representations and is not to scale, including the relationship of the individual components to one another. Identical reference symbols indicate the same object or component; reference symbols with different indices indicate functionally identical or similar objects or components.

[0070] It shows Fig. 1 a schematic representation of an exemplary customer adaptation of a hair growth preparation according to the invention.

[0071] In the Fig. 1 The example shows a customer 200 seeking help with thinning hair growth 1. The first phase I is a customer survey or needs assessment 300, which includes tests, measurements, and questionnaire evaluations AH.

[0072] A second phase II of a preparation adaptation 400 illustrates that a first hair growth preparation 100 comprises substances or substance compositions SU selected as a function of the tests AC. A further, second hair growth preparation 100a is illustrated by way of example, in which substances or substance compositions VX were selected as a function of the tests DF. A third hair growth preparation 100b is also illustrated by way of example, in which a substance or substance composition Y is selected as a function of the test G, as well as a substance or substance composition Z as a function of the test H, and the substance or substance composition S as a function of the test A.A fourth and final exemplary embodiment of a hair growth preparation 100c comprises the substance or substance composition V in function of the test D, the substance or substance composition X in function of the test F and the substance or substance composition Y in function of the test G.

[0073] A third Phase III symbolically and exemplifies that although Customer 200 from Phase I has become a "changed" Customer 200a by taking Hair Growth Supplement 100, no significant progress has yet been made in terms of improved hair growth. The same applies to Hair Growth Supplements 100a and 100c, or to Customers 200b and 200d. With Hair Growth Supplement 100b, however, Customer 200 has become Customer 200c with strong and voluminous hair growth. The timeline for Phases I-III is several months in each case. List of reference symbols

[0074] 1 - Thinning hair growth 2 - Strong, voluminous hair growth 100, 100a-100c - Hair growth preparation 200, 200a-200d - Customer 300 - Customer registration, needs assessment 400 - Preparation adaptation I - First phase II - Second phase III - Third phase AH - Tests, measurements, questionnaire evaluations SZ - Substance or substance composition

Claims

1. Hair growth preparation for oral administration as daily dose, comprising L-cysteine and zinc, characterized in that the hair growth preparation comprises 1'000.0 mg to 2'000.0 mg L-cysteine and copper, calcium, magnesium, silicium, iron and cholecalciferol, as well as guar gum or locust bean gum for the retarded resorption in the small intestine and that a first basic version of the hair growth preparation for women, with 20.0 mg zinc and 2.5 mg iron or a second basic version of the hair growth preparation for men, with 25.0 mg zinc and 1.0 mg iron are selectable and that the composing substances or compositions of substances of the selected basic version are adapted or supplemented to the determined individual organic nutrient supply requirements of a female customer or male customer, on basis of evaluations of questionnaires and blood, urine, creatinine, saliva, hair, stool and breath tests.

2. Hair growth preparation according to claim 1, characterized in that the hair growth preparation comprises natural vitamin E in the form of alpha-tocopherol and gamma-tocopherol.

3. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises ascorbic acid.

4. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises biotin.

5. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises L-methionine.

6. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises pantothenic acid.

7. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises pyridoxine and / or pyridoxal and / or pyridoxamine.

8. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises cobalamin.

9. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises selenium.

10. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises nicotinic acid.

11. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises folic acid.

12. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises ubiquinone-10.

13. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises omega-3 fatty acids contained in micro capsules which are admixed to a powdery composition of the hair growth preparation.

14. Hair growth preparation according to one of the preceding claims, characterized in that the hair growth preparation comprises natural carotenoids, retinoids, thiamin, riboflavin, chromium, iodine, manganese, molybdenum, vanadium, calcium, potassium, a-lipoic acid, choline, inositol, L-carnitine, p-aminobenzoic acid, gamma aminobutyric acid, Sylimarin and citric bioflavonoids.

15. Procedure for the customized adaptation of a hair growth preparation with at least one adaptable substance composition according to claim 1 or according to one of the preceding claims 2-14, characterized in that the following procedure steps are carried out: a) - providing of a basic version of the hair growth preparation for women, with 20.0 mg zinc and 2.5 mg iron; b) - providing of a basic version of the hair growth preparation for men, with 25.0 mg zinc and 1.0 mg iron; c) - letting respond to questionnaires by a female customer or male customer; d) - executing of blood, urine, creatinine, saliva, hair, stool and breath tests; e) - determining on basis of the questionnaire evaluations and the blood, urine, creatinine, saliva, hair, stool and breath tests of the difference substances and difference dosages to the dosages of the basic version; f) - selecting the basic version of the hair growth preparation for women in the case of a female customer; g) - selecting of the basic version of the hair growth preparation for men in the case of a male customer; h) - adapting of the selected basic version of the hair growth preparation to the determined individual organic nutrient supply requirements of a female customer or male customer, by adding of the determined difference substances and difference dosages to the dosages of the selected basic version.

16. Mixture of substances containing the substances L-cysteine and zinc, for the application at the therapy against hair loss and for hair growth stimulation, characterized in that the mixture of substances contains 1'000.0 mg to 2'000.0 mg L-cysteine and that the mixture of substances contains also copper, calcium, magnesium, silicium, iron and cholecalciferol, as well as guar gum or locust bean gum for the retarded resorption in the small intestine and that a basic version of the mixture of substances for women, with 20.0 mg zinc and 2.5 mg iron or a basic version of the mixture of substances for men, with 25.0 mg zinc and 1.0 mg iron are selectable and that the composing substances or compositions of substances of the selected basic version are adapted or supplemented to the determined individual organic nutrient supply requirements of a female customer or male customer, on basis of evaluations of questionnaires and blood, urine, creatinine, saliva, hair, stool and breath tests.

17. Mixture of substances for the application according to claim 16, characterized in that the mixture of substances contains natural vitamin E in the form of alpha-tocopherol and gamma-tocopherol.

18. Mixture of substances for the application according to claim 16 or 17, characterized in that the mixture of substances contains ascorbic acid.

19. Mixture of substances according to one of the preceding claims 17-18, characterized in that the mixture of substances contains biotin.

20. Mixture of substances according to one of the preceding claims 17-19, characterized in that the mixture of substances contains L-methionine.

21. Mixture of substances according to one of the preceding claims 17-20, characterized in that the mixture of substances contains pantothenic acid.

22. Mixture of substances according to one of the preceding claims 17-21, characterized in that the mixture of substances contains pyridoxine and / or pyridoxal and / or pyridoxamine.

23. Mixture of substances according to one of the preceding claims 17-22, characterized in that the mixture of substances contains cobalamin.

24. Mixture of substances according to one of the preceding claims 17-23, characterized in that the mixture of substances contains selenium.

25. Mixture of substances according to one of the preceding claims 17-24, characterized in that the mixture of substances contains nicotinic acid.

26. Mixture of substances according to one of the preceding claims 17-25, characterized in that the mixture of substances contains folic acid.

27. Mixture of substances according to one of the preceding claims 17-26, characterized in that the mixture of substances contains ubiquinone-10.

28. Mixture of substances according to one of the preceding claims 17-27, characterized in that the mixture of substances contains omega-3 fatty acids contained in micro capsules which are admixed to a powdery composition of the mixture of substances.

29. Mixture of substances according to one of the preceding claims 17-28, characterized in that the mixture of substances contains natural carotenoids, retinoids, thiamin, riboflavin, chromium, iodine, manganese, molybdenum, vanadium, calcium, potassium, a-lipoic acid, choline, inositol, L-carnitine, p-aminobenzoic acid, gamma aminobutyric acid, Sylimarin and citric bioflavonoids.