COMPOSITIONS AND METHODS FOR MODULATING 15-PGDH ACTIVITY
DE602013087552T2Active Publication Date: 2026-06-10BOARD OF RGT THE UNIV OF TEXAS SYST +2
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Patent Information
- Application Number
- DE602013087552
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2012-04-16
- Filing Date
- 2013-04-16
- Publication Date
- 2026-06-10
- Estimated Expiration
- 2033-04-16
AI Technical Summary
Technical Problem
Current therapies for modulating 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) activity and prostaglandin levels are limited in efficacy and specificity, particularly in treating diseases and disorders associated with these biological processes.
Method used
Development of specific compounds, such as SW033291, SW054384, and SW145753, which selectively inhibit or modulate 15-PGDH activity, thereby regulating prostaglandin levels and providing therapeutic benefits in various biological processes.
Benefits of technology
These compounds effectively regulate 15-PGDH activity, reducing prostaglandin levels, and demonstrate neuroprotective effects, promoting wound healing, bone formation, and treating inflammatory conditions in preclinical models.
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