METHOD FOR SCREENING A LINK TO CONTROL RNA FUNCTION
Patent Information
- Application Number
- DE602019064285
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2019-03-14
- Publication Date
- 2025-01-01
- Estimated Expiration
- 2039-03-14
AI Technical Summary
Current methods for drug discovery targeting RNA molecules are inefficient due to limitations in predicting stable secondary structures of long RNA strands and lack of diversity in RNA binding sites for low-molecular-weight compounds, which hinders the development of effective small molecule drugs.
A method that calculates the existence probability of local secondary structures in RNA sequences using multiple prediction algorithms, selects suitable stem-loop structures, and designs probes to screen for low-molecular-weight compounds that stabilize these structures, thereby regulating mRNA translation and gene expression.
This approach enables the precise identification of target sites for low-molecular-weight compounds to modulate gene expression, facilitating the development of effective small molecule drugs by stabilizing specific RNA substructures and enhancing the drug discovery process.