METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF DIABETES
DE602019084835T2Active Publication Date: 2026-05-13BG NEGEV TECHNOLOGIES & APPLICATIONS LTD +1
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Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- BG NEGEV TECHNOLOGIES & APPLICATIONS LTD
- Filing Date
- 2019-02-04
- Publication Date
- 2026-05-13
AI Technical Summary
Technical Problem
Type 2 diabetes (DM2) is difficult to treat effectively in the long term due to insulin resistance and progressive loss of islet beta-cell function, leading to complications such as cardiovascular disease, diabetic neuropathy, and diabetic retinopathy, despite current treatment protocols.
Method used
A scaffold-cell construct comprising a biocompatible polymer of PLLA and PLGA with recombinant myoblasts overexpressing GLUT4, which are transplanted to enhance glucose uptake and restore glucose homeostasis.
Benefits of technology
The scaffold-cell construct improves glucose uptake rates and restores normoglycemia in diabetic subjects, providing a therapeutic avenue for treating diabetes and metabolic syndrome.
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