Condensed pyrazole compounds as SARM1 inhibitors
DE602021044946T2Active Publication Date: 2025-12-24DISARM THERAPEUTICS INC
View PDF 0 Cites 0 Cited by
Patent Information
- Application Number
- DE602021044946
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2021-04-07
- Publication Date
- 2025-12-24
- Estimated Expiration
- 2041-04-07
AI Technical Summary
Technical Problem
Current treatments for neurodegenerative diseases and axonal degeneration are inadequate, and there is a need for effective inhibitors of SARM1 to prevent or reduce axonal degeneration.
Method used
Development of pyrazole derivatives that inhibit SARM1 activity, specifically targeting the catalytic residues of SARM1 to prevent NAD+ degradation, thereby reducing axonal degeneration.
Benefits of technology
The pyrazole derivatives effectively inhibit SARM1, reducing axonal degeneration and potentially treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and traumatic neuronal injuries.
✦ Generated by Eureka AI based on patent content.
Need to check novelty before this filing date? Find Prior Art
No text content released.