USE OF BREASTFEEDING EXOSOMES AS RADIOISOTOPE VEHICLES FOR THE DIAGNOSIS AND TREATMENT OF NEOPLASMS
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO ARAID
- Filing Date
- 2021-03-29
- Publication Date
- 2026-04-22
AI Technical Summary
The challenge lies in developing efficient and safe transport vehicles that can specifically target and deliver therapeutic agents, including radioisotopes, to tumor sites, including central hypoxic regions, to improve theragnosis in tumors.
Utilizing exosomes derived from breast milk that express high levels of the sodium-iodine symporter (NIS) to accumulate radioisotopes, enabling targeted visualization and treatment of tumors and metastases through techniques like PET or SPECT, and therapeutic agents like 131I.
Exosomes effectively accumulate radioisotopes in tumors, allowing for precise diagnosis and treatment with minimal side effects, as they exhibit high tumor selectivity and tropism, avoiding ethical concerns and invasive methods.