Infusion bag, and method for producing same
Patent Information
- Application Number
- EP2023702490
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-02-04
- Filing Date
- 2023-02-03
- Publication Date
- 2024-12-11
AI Technical Summary
The existing manufacturing process for infusion bags is energy- and time-consuming, and can lead to a reduction in the quality of the parenteral nutritional solutions, as they often require autoclaving to maintain sterility, which is not efficient and may compromise the contents.
An infusion bag design with a pierceable membrane in the connector port that allows aseptic filling and sealing, using a flexible, detachable area with a membrane that can be opened only when the bag is filled in an aseptic zone, ensuring the interior remains sterile until use, and a method for sterilizing the outer surface before filling.
This approach improves the aseptic filling and closing of infusion bags, maintaining sterility during production and transportation, reducing energy consumption and preserving the quality of the contents, while allowing for efficient and secure sealing after filling.
Smart Images
Figure 1.1
Abstract
Description
[0001] Infusion bag and method for its manufacture
[0002] Description
[0003] Field of the invention
[0004] The invention relates to an infusion bag and a method for its production and filling. In particular, the invention relates to a multi-chamber bag containing a parenteral nutritional composition.
[0005] Background of the invention
[0006] An infusion bag is shown, for example, in the published patent application WO 2004 / 084793 A1. The infusion bag is made of two films welded together. The infusion bag includes at least two connectors for withdrawing and injecting fluid.
[0007] Each connector consists of a lower part that is welded into the infusion bag. The lower part is sealed with an upper part, with a sealing element pressed in between the upper and lower parts.
[0008] When manufacturing such an infusion bag, the lower parts can be used as ports to fill the infusion bag.
[0009] For parenteral nutrition, infusion bags with multiple chambers, for example, three chambers, are particularly well known. The different compositions of a parenteral nutrition solution are arranged in the chambers.
[0010] Only immediately before using the infusion bag are the liquids from the chambers mixed together, for example by opening pullable weld seams, so-called peel seams, between the chambers, for example by rolling the bag and printing on the chamber.
[0011] To produce a sterile infusion bag, especially one filled with a parenteral nutrition solution, it may be necessary to autoclave it after production. This is energy- and time-consuming and, in some cases, can also lead to a reduction in the quality of the nutritional compositions or components contained in the infusion bag. It is therefore advantageous if the infusion bag can be filled aseptically, especially in an aseptic zone.
[0012] Object of the invention
[0013] The invention is based on the object of providing an infusion bag and a method for its production, in which the filling of the infusion bag and closing of the ports in an aseptic zone is improved.
[0014] Summary of the invention
[0015] The object of the invention is already achieved by an infusion bag and by a method for producing an infusion bag according to one of the independent claims. Preferred embodiments and further developments of the invention can be found in the subject matter of the dependent claims, the description, and the drawings.
[0016] The invention relates to an infusion bag which is designed to be filled with a medicinal liquid, wherein the infusion bag comprises at least one port which is designed as a lower part of a connector and which comprises a head piece with a connecting region for an upper part of the connector, wherein a sealing element can be clamped between the upper part and the lower part, wherein the lower part comprises a welded-in section via which the lower part is connected to at least a first chamber of the infusion bag, wherein the lower part has a flexible, clampable region above the welded-in section and wherein the lower part, in particular between the sealing element and the flexible, clampable region, comprises a pierceable membrane which closes off access to the flexible, clampable region in the port.The pierceable membrane is arranged between the sealing element and the flexible, clampable area, in particular when the upper part is mounted on the lower part of the connector.
[0017] According to claim 1, the invention is described by an infusion bag, designed to be filled with a medicinal liquid, wherein the infusion bag comprises at least one port which is designed as a lower part of a connector which comprises a head piece with a connecting region for an upper part of the connector, wherein a sealing element can be clamped between the upper part and the lower part, wherein the lower part comprises a welded-in section via which the lower part is connected to at least a first chamber of the infusion bag, wherein the lower part has a flexible, clampable region above the welded-in section, characterized in that the flexible, clampable region forms a body with shoulders and merges into the head piece via a neck, wherein the lower part comprises a pierceable membrane which closes off access to the flexible, clampable region in the port.
[0018] The invention is based on the discovery that this empty bag can be sealed by a membrane in the lower part of the connector in such a way that the interior of the bag remains sterile when the bag is transported, for example, into an aseptic zone. The empty bags can be sterilized after production, for example, by means of radiation, ETO gas, heat, or another suitable method. During further transport of the empty bags, the interior of the bag, sealed by the membrane, remains sterile.
[0019] Only when the infusion bag is ready to be filled and is located in an aseptic zone is the membrane pierced, for example, using a filling nozzle, and the bag opened. After the membrane is opened, the bag, or at least one chamber of the bag, is filled using the filling nozzle. The membrane is a pierceable membrane, particularly one with a filling nozzle. It can be opened by piercing it.
[0020] Because of the flexible, clampable area between the weld-in section and the upper part, the bag can be closed after filling by clamping off the lower part. The upper part can then be placed on the lower part, for example in a subsequent station while still within the aseptic zone, to form a connector. The membrane is preferably formed integrally with the lower part. In particular, the lower part and the membrane are formed by a one-piece plastic injection-molded part. As a result, access to the flexible, clampable area and thus also access to the interior of the bag is initially securely closed off by the membrane. In another embodiment, the membrane can also be designed as an insert. This is then preferably clamped into the lower part.
[0021] According to a preferred embodiment, the membrane has a wall thickness of 0.05 to 1 mm, preferably 0.1 to 0.3 mm. Such a wall thickness provides a secure seal for access to the flexible, clampable area, but can be easily opened by piercing.
[0022] The infusion bag is designed, in particular, as a multi-chamber bag. In particular, it can comprise at least two or three chambers. At least one chamber, preferably all chambers, of the multi-chamber bag is provided with the bottom part with the pierceable membrane.
[0023] The upper part can comprise a break-off cap. Such a break-off cap has a predetermined breaking point, for example in the form of a weakening line. Before the connector is used, the break-off cap is removed and the sealing element is now exposed so that a spike or a needle can be inserted to withdraw or add liquid, in particular an additive, for example an active ingredient. The sealing element is preferably self-sealing, i.e. it closes automatically after the spike or needle is pulled out.
[0024] The membrane is preferably arranged at a distance from the sealing element in a connecting region of or between the upper part and the lower part. This connecting region can also be considered the head of the lower part.
[0025] The connecting area comprises at least one collar and / or a groove for locking the upper part onto or with the lower part. The membrane is therefore preferably located in an upper area of the lower part that is less flexible than the clampable area. The membrane is preferably arranged in the head piece of the lower part.
[0026] Preferably, the membrane is spaced from the opening of the lower part; in particular, the membrane can be located in the lower half of the head of the lower part. This ensures that the filling nozzle is securely guided, and there is no risk of the port kinking during filling. In particular, the membrane is arranged in a range of 4 mm to 8 mm, preferably 5 mm to 7 mm, below the end face of the head region.
[0027] Furthermore, the membrane can be located at the level of a circumferential groove, as provided in one embodiment. This can be advantageous during injection-molded production, as the wall of the lower part is thinner in the area of the groove. The material thus saved can at least partially form the membrane.
[0028] The invention further relates to an infusion bag filled with a medicinal fluid, wherein the membrane is perforated. Such an infusion bag has, instead of a closed membrane wall, a broken edge or residual wall of the membrane.
[0029] Preferably, the upper part is placed on the lower part and locked into place. The sealing element is clamped between the upper and lower parts.Furthermore, the present invention also comprises a port for an infusion bag or the one described above, which is designed as a lower part of a connector, which comprises a head piece with a connection region for an upper part of the connector, wherein a sealing element can be clamped between the upper part and the lower part, wherein the lower part comprises a welded-in section via which the lower part can be connected to at least a first chamber of the infusion bag, wherein the lower part has a flexible, clampable region above the welded-in section, characterized in that the flexible, clampable region forms a body with shoulders and merges into the head piece via a neck, wherein the lower part comprises a pierceable membrane which closes off access to the flexible, clampable region in the port.
[0030] Preferably, the membrane is arranged in the headpiece of the lower part. This supports a defined opening of the membrane.
[0031] In one embodiment, the headpiece comprises a collar followed by a groove, with another collar for latching the upper part. Preferably, the membrane is located in the region of the, preferably circumferential, groove.
[0032] The medicinal liquid is a liquid used for medical purposes and is preferably administered intravenously. In a preferred embodiment, the medicinal liquid is an infusion solution. Possible examples of such infusion solutions include sterile water;
[0033] Salt solutions, in particular solutions containing NaCl, KCl, CaCl and / or Mg; solutions containing carbohydrates, in particular glucose solutions;
[0034] Solutions, emulsions and / or suspensions containing nutrients for parenteral nutrition, in particular lipids, amino acids and / or glucose;
[0035] Colloid solutions, particularly for blood replacement therapy (e.g., Voluven®); and / or so-called premixed systems, in which an active ingredient, e.g., paracetamol, is already added to the medicinal liquid.
[0036] The invention further relates to a method for filling an infusion bag with a medicinal liquid, comprising the steps of:
[0037] - Providing an infusion bag with a sterilized interior sealed with a membrane, wherein the infusion bag comprises at least one lower part of a connector with a welded section, via which it is connected to at least one chamber of the infusion bag, wherein the lower part has a clampable area;
[0038] - Providing a sterilized upper part with a sealing element;
[0039] - Sterilising the outer surface of the lower part, at least in the area of the membrane, in particular by means of steam;
[0040] - piercing the membrane, in particular by means of a filling nozzle and filling the at least one chamber with the medicinal liquid by means of the filling nozzle;
[0041] - Placing the upper part, in particular together with the sealing element, onto the lower part;
[0042] - Clamping off the lower part at least after the step of filling the at least one chamber. The infusion bag is preferably sterilized, in particular by means of radiation, before filling, in particular before being introduced into the aseptic zone.
[0043] In particular, a multi-chamber infusion bag is used.
[0044] In a further development of the invention, the filling nozzle is placed sealingly on the lower part.
[0045] In particular, a filling nozzle can be used here, which comprises a filling tube with which the membrane is pierced.
[0046] A sheathing tube can extend around the filling tube and sits sealingly on the lower part, in particular on the head of the lower part.
[0047] Furthermore, the filling nozzle can comprise an annular channel extending around the filling tube through which steam can be released for sterilization purposes.
[0048] In particular, a filling nozzle can be used in which the filling tube protrudes from the annular channel and extends into the lower part during filling. The annular channel is formed by a space between the filling tube and a sheathing tube. In particular, the sheathing tube rests tightly against the head of the lower part during filling of the infusion bag.
[0049] After filling, the lower part is sealed with the upper part. This takes place in an aseptic zone. The now finished, filled and sealed infusion bag can then be packaged in a secondary bag.
[0050] The invention further relates to the use of the method described above for producing an infusion bag, in particular a multi-chamber bag.
[0051] Furthermore, the invention relates to an infusion bag that can be produced or is produced by the method.
[0052] Brief description of the drawings
[0053] The subject matter of the invention will be explained in more detail below with reference to the drawings Fig. 1 to Fig. 13.
[0054] Fig. 1 shows a multi-chamber bag arranged in a secondary packaging.
[0055] Fig. 2 and Fig. 3 are views of the connector, which serves as a withdrawal port.
[0056] Fig. 4 is a sectional view taken along the line AA of Fig. 3.
[0057] Fig. 5 and Fig. 6 are views of the connector, which serves as an injection port.
[0058] Fig. 7 is a sectional view taken along the line AA of Fig. 6.
[0059] Fig. 8 to Fig. 10 schematically show the steps for filling the infusion bag. Fig. 11 is a longitudinal section of the lower part, which is intended for the withdrawal port, during filling with a filling nozzle.
[0060] Fig . 12 is a corresponding longitudinal section of the lower part which is used for the injection port .
[0061] Fig. 13 is a flow chart of the steps for manufacturing an infusion bag.
[0062] Detailed description of the drawings
[0063] Fig. 1 shows an infusion bag 10 which, in this exemplary embodiment, is designed as a three-chamber bag. The chambers 15a - 15c are separated from one another by pull-open or tear-open weld seams 14. The various components of a parenteral nutrition composition are located in the chambers 15a - 15c. For example, a first chamber is filled with a lipid emulsion, a second chamber with an amino acid solution and / or a third chamber with a glucose solution or electrolyte solution. Before the infusion bag 10 is used, the chambers 15a - 15c are connected to one another by separating the pull-open weld seams 14, for example by rolling and pressing the infusion bag 10.
[0064] The infusion bag 10, formed from two films, is sealed by longitudinal welds 11 and transverse welds 12. The infusion bag 10 includes a hanger 13 for hanging on a rack.
[0065] The connectors 20a and 20b, as well as the blind cap 20c, are welded into a transverse weld seam 12. The blind cap 20c and the connectors 20a, 20b each comprise a lower part 200, which serves as a port for filling one of the chambers 15a-15c. The lower parts / ports 200 are each closed with an upper part 300.
[0066] The connector 20a serves as a withdrawal port and is closed with an upper part 300, which includes a break-off cap 301. Withdrawal is generally performed by inserting a spike connected to a transfer system.
[0067] The connector 20b serves as an injection port and also comprises an upper part 300 with a break-off cap 301. The injection, for example of an active substance, can be carried out in particular by means of a needle syringe.
[0068] The blind cap 20c is closed with a cap 300. The blind cap 20c is used only to fill the chamber 15c, not for adding or removing liquid.
[0069] The infusion bag 10, including its exterior, is sterile and is contained in a secondary packaging 50. The secondary packaging 50 is formed here from two films welded together. The secondary packaging 50 is designed as a tear-open package. For this purpose, at least one notch 51 can be present in one of the weld seams.
[0070] Preferably, as shown, two notches 51 are introduced.
[0071] Fig. 2 is an external view of a connector 20, in this case connector 20a, which serves as a removal connector. The connector 20 / 20a is formed by a lower part 200 and an upper part 300.
[0072] The lower part 200 comprises a welding section 201 for welding into the outer seam 11 of the infusion bag 10. As shown in comparison with the side view according to Fig. 3, the welding section 201 can have an elongated, in particular boat-shaped, shape.
[0073] The welded section 201 merges into a flexible, clampable area 202. During filling, the clampable area 202 can assume a valve function. After filling the infusion bag 10, the clampable area 202 can be pressed closed using a clamp, and the infusion bag 10 can be moved to the next station, at which the opened port 200 is closed, in particular by pressing the upper part 300 onto the lower part 200. However, the lower part can also be clamped off by clamping the bag around the area of the base section of the port.
[0074] The clampable region 202 forms a body which, via a neck 203, transitions into a head region or head 208 (see Fig. 4), which serves as a connecting region for the upper part 300. In detail, the clampable region 202 forms a body with shoulders 209, to which the neck 203 adjoins at the top (see also Fig. 3). This configuration serves in particular to improve the clamping behavior. The clampable region 202 can also be used to clamp a transfer system during infusion.
[0075] The upper part 300 comprises a collar 304, by which the connector 20 / 20a can be gripped. Furthermore, the upper part 300 comprises a break-off cap 301, which is connected to the remaining upper part 300 via a predetermined breaking point 302.
[0076] Fig. 4 is a longitudinal section along line AA of Fig. 3. The head piece 208, which serves to connect to the upper part 300, comprises a collar 205 at the bottom, followed by a groove 206. This is followed by another collar 204. The collar 204 is rounded in this exemplary embodiment.
[0077] The collar 204 serves to snap on the upper part 300. A groove 306 of the upper part 300, which is complementary to the collar 204, snaps onto the collar 204. Only the wall of the upper part 300 rests against the lower collar 205. A sealing element 30 is pressed in between the upper part 300 and the lower part 200. The sealing element 30 rests on the end face of the head 208. In this exemplary embodiment, the sealing element 30 comprises a ring 32 surrounding it, which is held in a form-fitting manner between the upper part 300 and the lower part 200. Due to the circumferential ring 32, which is connected to the remaining sealing element 30 via a radially extending circumferential web 33, the sealing element 30 is not pressed out even under greater forces, such as those that occur when piercing with a spike.
[0078] The sealing element 30 comprises a depression 31 on the upper side, which in particular facilitates centering during piercing.
[0079] The upper part 300 further comprises a conically shaped insertion area 307, which also facilitates the insertion of a spike. The conical insertion area 307 protrudes beyond the collar 304 of the upper part 300.
[0080] The membrane 207, which seals the empty bag, is located adjacent to the groove 206. Thus, during the injection molding of the lower part 200, material displaced through the groove 206 can form the membrane 207.
[0081] Fig. 5 is a corresponding top view and Fig. 6 a side view of the connector 20 / 20b, which serves as an injection port. This connector 20b is also formed from a lower part 200 and an upper part 300, the upper part having a break-off cap.
[0082] The connector 20b has a smaller diameter. This serves for inserting a syringe, preferably the cannula of a needle syringe.
[0083] Fig . 7 is a longitudinal section along the line AA of Fig . 6 .
[0084] Connector 20b is largely designed similarly to connector 20a. Here, too, membrane 207 is located at the level of a groove 206.
[0085] In contrast to the connector shown in Fig. 4, the wall of the upper part 300 does not surround the collar 205. Rather, the collar 205 serves as a stop for the upper part 300.
[0086] The sealing element 30 rests on the front side of the head 208 of the lower part 200.
[0087] In contrast to the connector shown in Fig. 4, the sealing element 30 does not comprise a circumferential ring. The sealing element 30 is simply pressed between the lower part 200 and the upper part 300. When piercing with a needle, the forces generally do not exceed those that occur when a spike is used.
[0088] The predetermined breaking point 302 runs flush with the adjacent sealing element 30. After breaking off the break-off cap 301, the sealing element 30 is thus easily accessible. The sealing element 30 can include a recess 31, which facilitates insertion with a syringe. Fig. 8 to Fig. 10 schematically show the filling of the infusion bag 10.
[0089] As shown in Fig. 8, the head region or head 208 of the lower part 200 is first sterilized by steam 40. The steam 40 particularly impacts the outer side of the membrane 207.
[0090] Then, as shown in Fig. 9 and Fig. 10, the membrane 207 is pierced by a filling nozzle 400, and the infusion bag 10 is filled. A peripheral portion of the membrane 207 remains.
[0091] Fig. 11 shows in a longitudinal section how the lower part 200 of the connector 20a serving as a removal port is connected to the filling nozzle 400 during filling.
[0092] The filling nozzle 400 comprises a filling tube 401, which extends through the head 208 of the lower part during filling. The filling tube 401 pierces the membrane 207.
[0093] The filling tube 401 is arranged in a cladding tube 404. An annular channel 405 is formed between the filling tube 401 and the cladding tube 404.
[0094] During filling, the cladding tube 404 sits sealingly on the end face of the head 208. For this purpose, the cladding tube 404 in this embodiment has a collar 407 on the end face, which is adapted to the shape of the end face of the head 208.
[0095] Sterilization can be carried out via the ring channel 405 using steam 40.
[0096] At a step 406, the outer diameter of the filling tube 401 decreases in the direction of the opening of the filling tube 401. At the same time, the inner diameter of the cladding tube 404 decreases, so that its wall thickness increases. This allows for a particularly robust design.
[0097] As shown in Fig. 12, the filling nozzle 400 for the injection port is designed accordingly except for the dimensions.
[0098] The filling tube 401 has a smaller diameter than the filling nozzle according to Fig. 11 and the collar 403 of the cladding tube 404 is adapted to the different shape of the head 208.
[0099] Fig. 13 shows a flow chart of the steps for producing an infusion bag according to an embodiment of the method according to the invention.
[0100] First, a sterilized infusion bag 10 and a sterilized upper part 300 are provided.
[0101] The infusion bag 10 and the upper part 300 are transferred into the aseptic zone.
[0102] The lower part 200, in particular the head 208 of the lower part 200 including the membrane 207, is then sterilized by means of steam 40.
[0103] The membrane 207 is then pierced by means of the filling nozzle 400, in particular by means of the filling tube 401.
[0104] The infusion bag 10 is then filled. The lower part 200 is subsequently clamped off, in particular directly or indirectly, and the filled infusion bag 10 is transferred to the next station, where the lower part 200 is closed by attaching the upper part 300. The infusion bag 10 can then be packaged in a secondary bag 50, for example, while still in the aseptic zone. The secondary bag 50 is preferably impermeable to oxygen.
[0105] The invention has made it possible to improve the aseptic filling of an infusion bag 10.
[0106] Reference symbol list
[0107] 10 infusion bags
[0108] 11 Longitudinal weld seam
[0109] 12 Cross weld seam
[0110] 13 trailers
[0111] 14 on pullable weld seam
[0112] 15a- 15c Chamber
[0113] 20 , 20a-20b connector
[0114] 20c Blind Cap
[0115] 30 sealing element
[0116] 31 depression
[0117] 32 rings
[0118] 33 jetty
[0119] 40 steam
[0120] 50 secondary bags
[0121] 51 notch
[0122] 200 lower part / port
[0123] 201 Weld-in section
[0124] 202 disconnectable area
[0125] 203 Neck
[0126] 204 collar
[0127] 205 collar
[0128] 206 groove
[0129] 207 Membran
[0130] 208 Head or headpiece
[0131] 209 Shoulder 300 Top
[0132] 301 Break-off cap
[0133] 302 predetermined breaking point
[0134] 304 Collar 305 Base part
[0135] 306 groove
[0136] 307 insertion area
[0137] 400 filling nozzle
[0138] 401 Filling pipe 403 Piercing section
[0139] 404 cladding tube
[0140] 405 Ring Canal
[0141] 406 Level
[0142] 407 collar
Claims
Claims:
1. Infusion bag (10) designed for filling with a medical fluid, wherein the infusion bag comprises at least one port (200) which is designed as a lower part (200) of a connector comprising a head piece (208) with a connection area for an upper part (300) of the connector (20a, 20b), wherein a sealing element (30) can be clamped between the upper part (300) and the lower part (200), wherein the lower part (200) comprises a weld-in section (201) via which the lower part (200) is connected to at least one first chamber (15a) of the infusion bag (10), wherein the lower part (200) has a flexible, clampable area (202) above the weld-in section (201), characterized in that the flexible, clampable area (202) forms a body with shoulders (209) and extends over a neck (203) transitions into the headpiece (208), the lower part (200) being a perforable membrane (207) includes, which closes off access to the flexible, detachable area (202) in the port (200).
2. Infusion bag (10) according to the preceding claim, characterized in that the perforable membrane (207) is arranged in the head piece (208) of the lower part (200).
3. Infusion bag (10) according to one of the preceding claims, characterized in that the membrane (207) is formed integrally with the lower part (200) or that the membrane is formed as an insert which is preferably clamped in the lower part (200).
4. Infusion bag (10) according to one of the above Claims, characterized in that the membrane (207) The infusion bag (10) has a wall thickness of 0.05 to 1 mm, preferably 0.1 to 0.3 mm. The infusion bag (10) according to one of the preceding claims is characterized in that the infusion bag (10) has several, in particular at least three, chambers (15a-15c), of which at least the first chamber (15a), in particular all chambers (15a-15c), are connected to the lower part (200) with the perforable membrane. (207) is or are provided. Infusion bag (10) according to one of the preceding claims, characterized in that the infusion bag (10) is filled with a medical fluid and the membrane (30) is perforated. Infusion bag (10) according to one of the preceding claims, characterized in that the upper part (300) together with the sealing element (30) closes the lower part (200). Infusion bag (10) according to one of the preceding claims, characterized in that the infusion bag (10) is packaged in a secondary packaging. Infusion bag (10) according to one of the preceding claims, characterized in that the upper part (300) comprises a snap-off cap (301). . Infusion bag (10) according to one of the preceding claims, characterized in that the membrane (207) is arranged spaced apart from the sealing element (30) in a connection area between the upper part (300) and the lower part (200). Infusion bag (10) according to one of the preceding claims, characterized in that the upper part (300) is placed on the lower part, wherein the upper part (300) and the lower part (200) are interlocked and the sealing element (30) is clamped between the upper part (300) and the lower part (200).Port (200) for an infusion bag (10) according to one of the preceding claims, which is designed as a lower part (200) of a connector (20a, 20b) comprising a head (208) with a connection area for an upper part (300) of the connector (20a, 20b), wherein a sealing element (30) can be clamped between the upper part (300) and the lower part (200), wherein the lower part (200) comprises a weld-in section (201) via which the lower part (200) can be connected to at least one first chamber (15a) of the infusion bag (10), wherein the lower part (200) has a flexible, clampable area (202) above the weld-in section (201), characterized in that the flexible, clampable area (202) forms a body with shoulders (209) and extends via a neck (203) transitions into the headpiece (208), the lower part (200) being a perforable membrane. (207) comprises a diaphragm which closes off access to the flexible, clampable area (202) in the port (200). Port (200) according to the preceding claim, characterized in that the diaphragm (207) is located in the headpiece. (208) of the lower part (200) is arranged. . Port (200) according to one of the two preceding claims, characterized in that the head piece (208) comprises a collar (205) followed by a groove (206), wherein a further collar (204) is provided for snapping the upper part (300) connects. . Port (200) according to one of the three preceding claims, characterized in that the membrane (207) is located in a region of the groove (206). . Method for filling an infusion bag (10) with a medical fluid, comprising the steps: - Providing an infusion bag (10) with a sterilized interior sealed with a membrane (207), wherein the infusion bag (10) comprises at least a lower part (200) of a connector (20) with a weld-in section (201) via which the lower part (200) is connected to at least one chamber (15a-15c) of the infusion bag (10), wherein the lower part (200) has a clampable area (202); - Providing a sterilized top part (300) with a sealing element (30) ; - Sterilizing the outer surface of the lower part (200) at least in the area of the membrane (207), in particular by means of steam; - Piercing the membrane (207), in particular by means of a filling nozzle (41) and filling the at least one chamber (15a-15c) with the medical fluid by means of the filling nozzle (41); - Placing the upper part (300) together with the sealing element (30) onto the lower part (200) ; - Clamping the lower part (200) at least after the step of filling the at least one chamber (15a-15c) . . Method according to the preceding claim, characterized in that the interior of the infusion bag (10) is cleaned before filling, in particular by means of radiation, is sterilized. . Method according to one of the preceding claims, characterized in that an infusion bag (10) with several chambers (10a-10c) is provided, each of which is filled via the lower part (200) of a connector (20). . Method according to one of the preceding claims, characterized in that the filling nozzle (41) is placed sealingly onto the lower part (200). . Method according to one of the preceding claims, characterized in that the filling nozzle (400) comprises a filling tube (401) and an annular channel (405) extending around the filling tube (401) for conveying steam. . Method according to one of the preceding claims, characterized in that the filling tube (401) protrudes from the annular channel (405) and extends into the lower part (200) during filling, wherein the annular channel (405) is formed by a gap between the filling tube (401) and a sheathing tube (404), wherein the sheathing tube seals against a head (208) of the lower part (200) when the infusion bag (10) is filled. . Method according to one of the preceding claims, characterized in that the infusion bag (10) is packaged in a secondary packaging, in particular a secondary bag (50). . Use of a method according to one of the preceding claims for manufacturing an infusion bag (10) , in particular a multi-chamber bag. Infusion bag (10) , manufactured by a method according to one of the preceding claims.