Low-alcohol disinfectant

Abstract

The invention relates to a low-alcohol disinfectant with an alcohol content of maximally 50 wt.%. The disinfectant leaves only a small amount of residue on the disinfected surfaces, in particular inanimate surfaces, because only a few non-volatile components are contained. The disinfectant also exhibits a good degree of material compatibility, in particular a better material compatibility with respect to sensitive surfaces than high-alcohol disinfectants. The disinfectant exhibits a wide activity spectrum and short residence times, in particular a good virucidal effect. The invention additionally relates to a disinfectant concentrate and to the use of the disinfectant for disinfecting inanimate surfaces.

Description

[0001] Low-alcohol disinfectant

[0002] The invention relates to a low-alcohol disinfectant, a disinfectant concentrate for producing the disinfectant and the use of the disinfectant for disinfecting inanimate surfaces.

[0003] Alcohols have a known bactericidal effect. Ethanol, 1-propanol, and 2-propanol are the alcohols used in conventional disinfectants, with the alcohol content of the preparations generally ranging between 60 and 80%. The main advantage of alcohols is that they act very quickly against bacteria and dry without leaving residue when disinfecting surfaces. The virucidal efficacy of short-chain alcohols is discussed, but has only been demonstrated at a high concentration limit, which is assumed to be approximately 80% for ethanol. Even at concentrations above 80% vol., ethanol is not effective against all non-enveloped viruses in a sufficiently short time (source: KH Wallhäußer, "Praxis der Sterilisation, Desinfektion und Konservierung," G. Thieme Verlag, Stuttgart, New York, 2008, 6th edition, pp. 643-474).Therefore, additional antimicrobial agents are usually added to disinfectants to achieve virucidal effectiveness.

[0004] However, high-alcohol disinfectants with alcohol contents above 70% often exhibit poor material compatibility. While low alcohol content has improved material compatibility, this results in insufficient antimicrobial efficacy.

[0005] EP 1 020 115 A1 discloses a highly alcoholic disinfectant characterized by virucidal properties. The disinfectant contains 42 to 47 wt.% 1-propanol, 22 to 27 wt.% 2-propanol, 4 to 6 wt.% ethanol, 2-butanone, and at least 20 wt.% water. The high alcohol content of at least 68 wt.% achieves sufficient virucidal activity with low residues on a disinfected surface. However, the disinfectant is only suitable for alcohol-resistant surfaces and, due to its alcohol content, is subject to mandatory labeling.

[0006] The objective of the present invention was to develop a material-compatible disinfectant with the broadest possible spectrum of activity and short exposure times (< 2 to 5 minutes). Furthermore, the disinfectant should leave as little non-volatile residue as possible after drying. These objectives are achieved with a disinfectant according to claim 1, a disinfectant concentrate according to claim 15, a carrier material according to claim 16, and a use according to claim 17.

[0007] Preferred embodiments of the invention with further advantages are the subject of the subclaims or described below.

[0008] The low-alcohol disinfectant according to the invention comprises

[0009] - 20 to 50 wt.%, preferably 25 to 50 wt.% of at least one monohydric alcohol with

[0010] 2 to 4 carbon atoms,

[0011] 0.1 to 3.0 wt.%, preferably 0.1 to 2.0 wt.%, more preferably 0.1 to 1.0 wt.% of at least one acid having a pKa value of less than 2.3 selected from the group consisting of organic diacids and organic sulfonic acids, ie alkanesulfonic acids, optionally at least one auxiliary substance and water.

[0012] The percentages by weight (wt%) are based on the total weight of the disinfectant. The percentages by weight relating to alcohol and acid refer to the total amount of all alcohols or acids according to the invention mentioned above in the disinfectant. The monohydric alcohols contained in the disinfectant are aliphatic alcohols, so-called alkanols. The disinfectant contains one or more monohydric alcohols with 2 to 4 carbon atoms in an amount of 20 to 50 wt%, preferably 25 to 50 wt%, particularly preferably 30 to 50 wt%, in particular 44 to 50 wt%, whereby the percentage by weight refers to the total amount of all monohydric alcohols in the disinfectant.

[0013] In a preferred embodiment, the disinfectant contains one or more alcohols selected from the group consisting of ethanol, 1-propanol (n-propanol), and 2-propanol (isopropanol). More preferably, the disinfectant contains, as monohydric alcohol, only one monohydric alcohol selected from ethanol, 1-propanol, and 2-propanol, or, as monohydric alcohols, a mixture of ethanol, 1-propanol, and 2-propanol, or, as monohydric alcohols, a mixture of 1-propanol and 2-propanol. In one embodiment, the disinfectant contains, as monohydric alcohols, a mixture of 1-propanol and 2-propanol, wherein the proportion of 2-propanol is greater than the proportion of 1-propanol, for example in a ratio of 2:1 to 5:1 2-propanol to 1-propanol. If only a single alcohol is used, it can be ethanol or 1-propanol, for example.

[0014] The disinfectant preferably contains the acid(s) in an amount of 0.2 to 3.0 wt.%, particularly preferably 0.2 to 2.0 wt.%, in particular 0.2 to 1.0 wt.%. The weight percentage refers to the total amount of all acids from the aforementioned groups. The lower limit for the acid concentration can advantageously also be higher, for example, 0.3, 0.4, or 0.5 wt.%.

[0015] The acid preferably has a pKa value of less than 2.0. The pKa value, also known as the acid constant, is the pK value of the acid, also referred to as pKa, with a for "acid." The pKa value is defined as the negative decimal logarithm of the equilibrium constant of a chemical reaction. For acids, the pKa or pKa is the negative decimal logarithm of the acid constant (pKa = -1g Ks or pKa = -1g Ka; Ks, Ka = acid (dissociation) constant). Water has a pKa value of 14 (pKw) at room temperature. For organic diacids, the pKa value for the first dissociation of an acid group, also known as pKsi, is relevant.

[0016] The disinfectant preferably contains one or more acids selected from the group consisting of maleic acid ((Z)-2-butenedioic acid), methanesulfonic acid, ethanesulfonic acid, 2-propanesulfonic acid, butanesulfonic acid, 1-propanesulfonic acid, octanesulfonic acid, oxalic acid (ethanedioic acid) and squaric acid (3,4-dihydroxycyclobut-3-ene-1,2-dione), particularly preferably selected from maleic acid, methanesulfonic acid, oxalic acid (ethanedioic acid) and squaric acid (3,4-dihydroxycyclobut-3-ene-1,2-dione). Maleic acid has a pKsi value of 1.9, methanesulfonic acid has a pKsi value of -1.9, 2-propanesulfonic acid has a pKsi value of -1.79, butanesulfonic acid has a pKsi value of -1.68, ethanesulfonic acid has a pKsi value of -1.68, 1-propanesulfonic acid has a pKsi value of -1.49, octanesulfonic acid has a pKsi value of -1.41, oxalic acid has a pKsi value of 1.25 and squaric acid has a pKsi value of 1.5.Maleic acid is used at a concentration of > 99%; therefore, the amount used in the examples refers to > 99% maleic acid. Oxalic acid is used at a concentration of > 98%; therefore, the amount used in the examples refers to > 98% oxalic acid. Squaric acid is used at a concentration of > 98%; therefore, the amount used in the examples refers to > 98% squaric acid. Methanesulfonic acid is used at a concentration of 70%; therefore, the amount used in the examples refers to 70% methanesulfonic acid. The concentrations stated in the patent claims and the description each refer to 100% active content of the acid, unless otherwise stated.

[0017] Preferred acids are maleic acid, oxalic acid, and methanesulfonic acid, individually or in combination, as these may not require labeling due to their toxicological values ​​at the concentrations used. Oxalic acid and methanesulfonic acid are particularly preferred.

[0018] In one embodiment, the disinfectant contains ethanol, 1-propanol, 2-propanol, or a mixture thereof as the monohydric alcohol, and maleic acid, methanesulfonic acid, oxalic acid, squaric acid, or a mixture thereof as the acid. The acid mixture can be, for example, maleic acid and squaric acid, or oxalic acid and squaric acid. Likewise, the acid mixture can be, for example, maleic acid and oxalic acid, maleic acid and methanesulfonic acid, or oxalic acid and methanesulfonic acid.

[0019] In a further embodiment, the disinfectant contains as monohydric alcohol ethanol, 1-propanol, 2-propanol or a mixture thereof and as acid methanesulfonic acid and no other acids with a pKa value of less than 2.3.

[0020] The disinfectant preferably has a pH of less than 4.5, more preferably a pH between 1.5 and 3.0, particularly preferably between 2.0 and 3.0, and most preferably between 2.0 and 2.5. At a pH greater than 2, personal protective equipment (PPE) advantageously does not need to be worn. The disinfectant can contain one or more excipients selected from the group consisting of pH adjuster, complexing agent, surfactant, corrosion inhibitor, perfume, and dye. The disinfectant preferably contains only pH adjuster and / or complexing agent as excipients. The disinfectant particularly preferably contains no excipients.

[0021] If auxiliary substances are contained in the disinfectant according to the invention, they are preferably present in the following amounts: pH adjusting agent in an amount of 0.01 to 3.0 wt.%,

[0022] Complexing agent in an amount of 0.1 to 5.0 wt.%,

[0023] - surfactants in an amount of 0.1 to 10 wt.%,

[0024] Corrosion inhibitors in an amount of 0.1 to 1.0 wt.%,

[0025] Perfume in an amount of 0.01 to 1.0 wt.% and

[0026] Dyes in an amount of up to 0.5% by weight.

[0027] In one embodiment, the disinfectant consists of

[0028] 20 to 50 wt.% of at least one monohydric alcohol having 2 to 4 carbon atoms,

[0029] 0.1 to 3.0% by weight, preferably 0.2 to 2.0% by weight of at least one acid having a pKa value of less than 2.3 selected from the group consisting of organic diacids and sulfonic acids,

[0030] 0 to 0.5% by weight of another antimicrobial agent,

[0031] 0 to 5.0 wt.% excipients, preferably 0 wt.% excipients,

[0032] 0 to 1.0 wt.% of at least one fatty acid and

[0033] Water, whereby the components add up to 100% by weight.

[0034] In a further embodiment, the disinfectant consists of

[0035] 25 to 50 wt.% of at least one monohydric alcohol selected from ethanol, 1-propanol and 2-propanol,

[0036] 0.2 to 2.0 wt.% of at least one acid with a pKa value of less than 2.3 selected from the group consisting of maleic acid, methanesulfonic acid, oxalic acid and squaric acid,

[0037] 0 to 5.0 wt.% excipients, preferably 0 wt.% excipients,

[0038] 0 to 1.0 wt.% of at least one fatty acid and

[0039] Water, whereby the components add up to 100% by weight. In another embodiment, the disinfectant consists of

[0040] 25 to 50 wt.% of at least one monohydric alcohol selected from ethanol, 1-propanol and 2-propanol,

[0041] 0.2 to 2.0 wt% methanesulfonic acid and no other acid with a pKa value of less than 2.3,

[0042] 0 to 5.0 wt.% excipients, preferably 0 wt.% excipients,

[0043] 0 to 1.0 wt.% of at least one fatty acid, and water, the components adding up to 100 wt.%.

[0044] The disinfectant according to the invention can consist only of water, monohydric alcohol(s), and strong acid(s) and can contain no other ingredients such as excipients or active ingredients. Since the alcohols and water evaporate without leaving any residue, this embodiment has the advantage of leaving very little residue on the disinfected surface.

[0045] In one embodiment, the disinfectant comprises about 50 wt% monohydric alcohols, a maximum of 2 wt% of the acid(s) and a pH of about 3.0 and is used as a disinfectant for living surfaces.

[0046] In a further embodiment, the disinfectant contains an antimicrobial agent in addition to the monohydric alcohols, in particular N-alkylaminopropylglycine, also known under the ECHA name Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid (CAS No. 139734-65-9). If N-alkylaminopropylglycine is included, the disinfectant preferably contains N-alkylaminopropylglycine in an amount of 0.1 to 0.5 wt.%. The amount of additional agent used must not be too large to keep the residue low. When using an additional antimicrobial agent, the acid concentration can be lower.

[0047] The disinfectant may additionally contain at least one fatty acid, preferably at least one saturated fatty acid. The fatty acid is preferably selected from saturated fatty acids having 8 to 12 carbon atoms. Particularly preferred fatty acids are octanoic acid and decanoic acid. The fatty acids enhance the antimicrobial effectiveness of the diacids or sulfonic acids in the disinfectant. The fatty acids are preferably present in the disinfectant in an amount of 0.1 to 1.0 wt. % when added. The fatty acids are preferably added when the acid with a pKa value of less than 2.3 is methanesulfonic acid. By adding the fatty acids, the effectiveness of the acids, in particular the effectiveness of methanesulfonic acid, is increased synergistically.The disinfectant preferably contains no quaternary ammonium compounds, no aldehydes, no guanidines, no active chlorine, no amines, no oxygen releasers, no aromatic alcohols, no metal ions, and no combinations of these active ingredients. The disinfectant particularly preferably contains no antimicrobial active ingredients other than monohydric alcohols with 2 to 4 carbon atoms. Furthermore, the disinfectant preferably contains no cationic oligomers and polymers, in particular no cationic oligomers or cationic polymers based on polysaccharides.

[0048] The disinfectant also preferably does not contain any toxicologically harmful ingredients, which is why it can be used without personal protective equipment even at a correspondingly low pH value, and enables simple and safe use.

[0049] The disinfectant according to the invention is preferably used for disinfecting inanimate surfaces, especially for surface disinfection. For this purpose, a disinfectant that leaves little residue is advantageous. Since water and alcohol are volatile, only the acid and any non-volatile components used remain as residue. The disinfectant leaves only minimal residue on the disinfected surfaces, especially inanimate surfaces, because it contains only a few non-volatile components. It also demonstrates good material compatibility, particularly better material compatibility with sensitive surfaces than high-alcohol disinfectants.

[0050] The disinfectant exhibits a broad spectrum of activity and short exposure times. Surprisingly, it was observed that a significant increase in antimicrobial efficacy can be achieved by adding small amounts of strong organic acids with a pKa value of < 2.3. The acids used are not known to be antimicrobial agents (e.g., Biocidal Products Regulation Annex 1: lactic acid, (+)-tartaric acid, acetic acid, propionic acid, ascorbic acid, and sodium salts of acetic acid and benzoic acid). The acids synergistically enhance the efficacy of the alcohols, although the alcohols alone, at the concentrations used of < 50 wt.%, do not exhibit sufficient efficacy against viruses with short exposure times.

[0051] To measure virucidal effectiveness, effectiveness against adenovirus was tested, among other things. The effectiveness against adenovirus was tested in accordance with EN 14476 under dirty conditions. The disinfectant according to the invention was shown to be sufficiently effective against adenovirus within 60 seconds. In addition, the disinfectant according to the invention was also shown to be very effective against poliovirus. The disinfectant is also effective against murine norovirus (MNV) within 60 seconds (RF > 4). The disinfectant can therefore be advertised as "virucidal" or "limited virucidal plus". A claim as "limited virucidal plus" is permissible with confirmed effectiveness against adenovirus and murine norovirus, although effectiveness against adenovirus is usually the limiting factor.A "virucidal" claim is permissible if the product has been proven to be effective against adenovirus, poliovirus, and murine norovirus. Additionally, the disinfectant also demonstrates efficacy against Mycobacterium terrae within 60 seconds and can therefore be claimed as "tuberculocidal."

[0052] The invention further relates to a disinfectant concentrate for producing a disinfectant according to one of claims 1 to 14 or as described above. In this case, the disinfectant is an aqueous application solution containing the disinfectant concentrate and water, preferably consisting of a mixture of the disinfectant concentrate and water.

[0053] The disinfectant concentrate itself essentially contains no water, but contains the other components of the disinfectant in concentrated form. The disinfectant is obtained by diluting the essentially water-free concentrate with water.

[0054] Furthermore, the invention relates to a carrier material, preferably a wipe, which is pre-impregnated with a disinfectant according to one of claims 1 to 14 or with a disinfectant concentrate according to claim 15 or as described above.

[0055] The liquid disinfectant can be used in the form of a pre-soaked, suitable carrier material for wipe disinfection, wherein the carrier material is preferably made of synthetic plastic from the group consisting of polyester, polyamide, polyurethane, polyethylene, polypropylene, polytetrafluoroethylene (PTFE), preferably polyester. The carrier material is, for example, a cloth, a sponge, or another application aid, preferably a wipe. Cloths made of natural materials, e.g., cellulose (lyocell) or viscose, which are compatible with the disinfectant solution, can also be used. The disinfectant used according to the invention is preferably applied in the form of a foam, a liquid, or in the form of a cloth, sponge, or other application aid impregnated with the disinfectant. The disinfectant can be applied directly to the surface to be treated without further dilution.

[0056] The invention further relates to the use of a disinfectant as described above or according to any one of claims 1 to 14 or a carrier material according to claim 16 for disinfecting an animate or inanimate surface, preferably an inanimate surface, and in particular for surface disinfection. The use of the disinfectant can bring about at least a log 4 reduction within 60 seconds against adenovirus, measured according to test standard EN 14476. Preferably, the use of the disinfectant or the carrier material impregnated with disinfectant brings about at least a log 4 reduction within 60 seconds against adenovirus, murine norovirus, and poliovirus, measured according to test standard EN 14476.

[0057] Examples

[0058] Disinfectants with the compositions listed in Tables 1a to 1c were prepared, and their antimicrobial efficacy was tested. The abbreviation "nb" stands for "not determined." Formulations V1 and V2 in Table 1c are comparative formulations and do not represent disinfectants according to the invention. The stated amount of 0.286 wt.% of methanesulfonic acid in the example corresponds to an active content of 0.2 wt.% acid.

[0059]

[0060] Table 1a: Recipes of the produced disinfectants (all data in wt.%) and measured pH value of the disinfectant

[0061] Table 1b: Recipes of the produced disinfectants (all data in wt.%) and measured pH value of the disinfectant

[0062]

[0063] Table 1c: Recipes of the disinfectants produced (all data in wt.%) and measured pH value of the disinfectant Table 1d: Recipes of the disinfectants produced (all data in wt.%) and measured pH value of the disinfectant

[0064] Testing efficacy against adenovirus

[0065] The efficacy of the manufactured disinfectants against adenovirus type 5, strain Adenoid 75, was determined according to the test standard EN14476:2013+A2:2019.

[0066] Table 2a: Effectiveness against adenovirus, c = 97%; dirty condition, T = 20°C, EN 14476:2013+A2:2019

[0067] Table 2b: Effectiveness against adenovirus, c = 97%; dirty condition, T = 20°C, EN 14476:2013+A2.2019

[0068] Table 2c: Effectiveness against adenovirus, c = 97%; dirty condition, T = 20°C, EN 14476:2013+A2.2019

[0069] It was shown that the tested formulations 1 to 8, 10 to 12, and 14 are effective against adenovirus in 60 s (RF > 4). Efficacy was achieved both for formulations containing a single acid (Examples 1 to 4, 8, 10 to 12, and 14) and for mixtures of acids and alcohols (Examples 5 to 7). Sufficient efficacy against adenovirus was also demonstrated at a low alcohol concentration (Examples 9 and 13). Even a low acid concentration with a low alcohol concentration (Examples 10 and 11) shows efficacy with a short exposure time of 1 minute. Ethanol at a concentration below 50 wt.% (Example V1) is ineffective. Malonic acid (pKs of 2.8; Example V2) also does not show the desired efficacy in combination with ethanol. In addition, the efficacy of some formulations was tested with an exposure time of 5 minutes.

[0070] A contact time of 5 minutes is the relevant contact time for the claim for disinfectant products for near-patient surfaces. Here, too, efficacy was achieved for formulations containing only one acid (Examples 18 and 19) and for mixtures of an acid with a fatty acid (Example 17). For formulation 17, the initial virus titer used was insufficient to achieve a reduction factor of >=4 due to the slightly higher cytotoxicity compared to formulations 18 and 19. A higher initial titer would also perfectly meet the requirement of greater than or equal to 4 μg levels.

[0071] Testing effectiveness against poliovirus

[0072] The effectiveness of the disinfectants produced against poliovirus was also

[0073] Type 1, strain LSc-2ab, determined according to test standard EN14476:2013+A2:2019.

[0074] Table 3: Effectiveness against poliovirus, c = 97%; dirty condition, T = 20°C, EN

[0075] 14476:2013+A2:2019

[0076] The tested disinfectants were effective against poliovirus within 60 seconds. The results demonstrate that a single acid alone in combination with an alcohol, as well as mixtures of acids and alcohols, exhibit very rapid effectiveness against poliovirus.

[0077] Testing efficacy against murine norovirus (MNV)

[0078] In addition, the effectiveness of the produced disinfectants against murine norovirus, isolate S99 Berlin, was determined according to the test standard EN14476.

[0079] Table 4: Effectiveness against MNV, c = 97%; dirty condition, T = 20°C, EN 14476:2013+A2.2019. All tested disinfectants are effective against murine norovirus within 60 s (RH > 4). Effectiveness is achieved both by combining a single acid with an alcohol and by using mixtures of the acids and alcohols.

[0080] Testing efficacy against M. terrae

[0081] In addition, the effectiveness of the produced disinfectants against M. terrae (dirty condition) was determined according to EN14348:2005.

[0082] A sample of the product to be tested is treated with a mycobacterial suspension, and this mixture is kept at the test temperature. After selected and specified exposure times, an aliquot of the mixture is immediately neutralized using validated methods to test for tuberculocidal activity. Colony counts are determined in each sample, and their reduction compared to the initial colony count is calculated. The method of choice is the dilution neutralization method. The membrane filtration method may only be used if no suitable neutralizing agent has been found.

[0083] Table 5: Efficacy against M. terrae, c - 97 %, dirty condition, T = 20° C,

[0084] EN 14348:2005

[0085] The efficacy within 60 seconds was also confirmed using Mycobacterium terrae (relevant for the "tuberculocidal" claim). All tested formulations were effective at a concentration of 97% in the suspension test.

[0086] The tuberculocidal efficacy of a selection of the manufactured disinfectants was additionally tested against M. terrae (dirty conditions) in a practical 4-field test according to prEN16615:2022 at room temperature (21.5 ± 3.5 °C). For the test, a standard TORK wipe (16.5 cm x 30 cm) was soaked with 16 ml of the respective formulation according to the method. The wipe was placed under a standard weight and then moved together with the weight without additional pressure over the 4 fields (each 5 cm x 5 cm; material: PVC) according to the specifications. Before the test began, a defined amount of the mixture of challenge substance and test suspension was pipetted onto the first of the 4 fields. The requirements are met if, after application and exposure time, a decimal-logarithmic (Ig) reduction of at least 4 levels was demonstrated on test field 1. In addition, the mean number of colony forming units per 25 cm 2on test fields 2 to 4 must be equal to or less than 50.

[0087] Table 6: Effectiveness against M. terrae, c = 100%, T = 21.5 + 3.5 °C, prEN 16615-2022

[0088] As shown in Table 6, the tested formulations 11 and 15 to 17 all meet the requirements of prEN 16615:2022.

[0089] All features and advantages arising from the claims and the description, including concentration ranges, compositions and process steps, can be essential to the invention both individually and in a wide variety of combinations.

Claims

Patent claims 1. Low-alcohol disinfectant, comprising - 20 to 50 wt.% of at least one monohydric alcohol having 2 to 4 carbon atoms, - 0.1 to 3.0 wt.% of at least one acid having a pKa value of less than 2.3 selected from the group consisting of organic diacids and organic sulfonic acids, - optionally at least one excipient and - Water.

2. Disinfectant according to claim 1, wherein the alcohol is contained in the disinfectant in an amount of 25 to 50 wt.%.

3. Disinfectant according to claim 1 or 2, wherein the disinfectant contains one or more alcohols selected from the group consisting of ethanol, 1-propanol and 2-propanol.

4. Disinfectant according to one of the preceding claims, wherein the disinfectant contains as monohydric alcohol only ethanol or as monohydric alcohols a combination of ethanol, 1-propanol and 2-propanol or as monohydric alcohols a combination of 1-propanol and 2-propanol.

5. Disinfectant according to one of the preceding claims, wherein the disinfectant contains the acid in an amount of 0.2 to 3.0 wt.%, in particular 0.2 to 1.0 wt.%.

6. Disinfectant according to one of the preceding claims, wherein the acid has a pKa value of less than 2.

0.

7. Disinfectant according to one of the preceding claims, wherein the disinfectant contains one or more acids selected from the group consisting of maleic acid, methanesulfonic acid, ethanesulfonic acid, 2-propanesulfonic acid, butanesulfonic acid, Contains 1-propanesulfonic acid, octanesulfonic acid, oxalic acid and squaric acid.

8. Disinfectant according to one of the preceding claims, wherein the disinfectant contains as monohydric alcohol ethanol, 1-propanol, 2-propanol or a mixture thereof and as acid maleic acid, methanesulfonic acid, oxalic acid, squaric acid or a mixture thereof. Disinfectant according to one of the preceding claims, wherein the disinfectant additionally contains at least one fatty acid, preferably a saturated fatty acid, and the fatty acid is particularly preferably selected from saturated fatty acids having 8 to 12 carbon atoms. Disinfectant according to one of the preceding claims, wherein the disinfectant has a pH of less than 4.5, preferably a pH between 1.5 and 3.

0. Disinfectant according to one of the preceding claims, wherein the disinfectant consists of 20 to 50 wt.% of at least one monohydric alcohol having 2 to 4 carbon atoms, 0.1 to 3.0% by weight, preferably 0.2 to 2.0% by weight of at least one acid having a pKa value of less than 2.3 selected from the group consisting of organic diacids and sulfonic acids, 0 to 0.5% by weight of another antimicrobial agent, 0 to 5.0 wt.% excipients, preferably 0 wt.% excipients, 0 to 1.0 wt.% of at least one fatty acid and Water, the components adding up to 100% by weight. Disinfectant according to one of the preceding claims, wherein the disinfectant contains only pH adjusters and / or complexing agents as auxiliary substances. Disinfectant according to one of the preceding claims, wherein the disinfectant contains a further antimicrobial active ingredient, in particular N-alkylaminopropylglycine. Disinfectant according to claim 13, wherein the disinfectant contains N-alkylaminopropylglycine in an amount of 0.1 to 0.5% by weight. Disinfectant according to one of the preceding claims, wherein the disinfectant contains no quaternary ammonium compounds, no aldehydes, no guanidines, no active chlorine, no amines, no oxygen releasers, no aromatic alcohols, no metal ions and no combinations of these active ingredients. Carrier material, preferably a wipe, which is pre-impregnated with a disinfectant according to one of claims 1 to 15. Use of a disinfectant according to one of claims 1 to 15 or a carrier material according to claim 16 for disinfecting an inanimate surface, in particular for reducing the adenovirus according to EN 14476 by at least 4 log levels.

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