Laboratory shaker with drawer and method for operating the drawer device

Abstract

The invention relates to a laboratory shaker (1) for shaking laboratory samples stored in sample containers in a chamber, which has a drawer device (40, 43) carrying drive components, which can be extended from a drawer space of the laboratory shaker for maintenance purposes.

Description

[0001] The invention relates to laboratory shakers for shaking laboratory samples stored in sample containers, in particular microorganisms in suspension, preferably mammalian cells in suspension.

[0002] Temperature-controlled laboratory shakers are used in biological, medical, and pharmaceutical laboratories for cultivating cells, bacteria, yeast, and other organisms in suspension. They are essential, for example, for the production of recombinant DNA, protein expression, or the screening of cultures. Since a laboratory shaker is primarily a shared piece of equipment that runs continuously at high speeds and under variable loads, it must be durable and reliable.

[0003] The key parameters relevant to a user of a laboratory shaker, especially an incubation shaker, are primarily a specific target temperature in the sample storage chamber, a specific speed, and a corresponding load-bearing capacity of the shaker platform, as well as the ability to control the CO2 concentration and humidity of an incubation atmosphere. Most applications require the use of different vessel sizes and types: from plates for initial screening to conical vessels for precultures and large flasks for plasmid production or protein expression. The constant demand for higher product yields has led to the invention of new flask types that offer better aeration than standard shake flasks. This allows the typical filling volume to be increased by up to 40%, resulting in a higher weight on the platform. Higher speeds above 250 rpm are required for applications with, for example, BE (Biochemical Energy).It is common practice to shake laboratory shakers to achieve a significant increase in cell density. When shaking sample plates for screening, it is important to achieve complete mixing and prevent cell sedimentation. The requirements for laboratory shakers are therefore extensive and include, in addition to continuous load capacity, sufficient versatility to handle all types of platform configurations, loads, and high rotational speeds. Durability and robustness are essential for reliable operation over many years.

[0004] An orbital shaker is a laboratory shaker in which a platform is moved in an elliptical or circular path, with the movement controlled by an eccentric. Generally, beakers, flasks, and other vessels are attached to the top of the platform, causing the liquid inside to swirl around the inner walls of the vessel to increase mixing and improve the interaction or exchange between the liquid and the local gaseous environment.

[0005] Orbital shakers are also specifically laboratory shakers that move a platform such that all points on the platform move integrally in a common, planar, orbital path, defined as a superposition of two translations and with an amplitude determined by an eccentric. Motion in a common, planar, orbital path means, in particular, that all points on the orbital shaker's platform move in an elliptical or circular path, the path lying in a plane. A "superposition of two translations" refers specifically to the fact that the shaker's platform motion can be considered a combination of two linear motions in different directions. This superposition results in the elliptical or circular path. An eccentric is a device used to convert translational motion into rotational motion.In this case, the eccentric defines the amplitude of the movement, i.e., the maximum deflection of the platform. In mechanics, an eccentric is a control disc mounted on a shaft, with its center point located off-axis.

[0006] These laboratory shakers have a chamber for holding the laboratory samples to be temperature-controlled; this chamber is usually located within a housing. Access to the chamber, through which the user places and removes the samples inside the housing, is generally via a housing opening that can be closed with a housing door. In some designs, the chamber also has a gas supply. These types of devices allow the cultivation of cells in a CO₂ atmosphere. They are called incubation shakers. A well-known laboratory shaker is the Innova® S44i, available from Eppendorf SE, Hamburg, Germany.

[0007] In a laboratory shaker, the long-term reliability of the drive is of paramount importance. The drive moves a platform that keeps the user's sample vessels in constant, uniform, orbital motion. This movement keeps, for example, eukaryotic suspension cells agitated in the culture medium and prevents them from settling in the vessel. This movement is essential for successful growth and, consequently, for successful protein expression. Contamination is one of the greatest safety risks in this application, so the sample chamber must be kept as clean as possible. Since the drive and the mechanical transmission of motion to the sample platform involve many parts, ensuring reliable operation depends on the ability to efficiently replace or analyze worn or defective parts at the user's site throughout the instrument's lifespan, without increasing the risk of chamber contamination.Ideally, the relevant parts should be quick and easy to access without having to move the usually heavy equipment or disassemble it on a large scale.

[0008] In existing laboratory shakers, significant portions of the drive components are often located within the chamber and are usually covered by an enclosure. According to the observations underlying the invention, the often complex shape and / or difficult-to-access contours of these components mean that impurities and contaminants in this area of ​​the chamber are difficult or impossible for the user to reach and therefore difficult to remove. Furthermore, with this arrangement, a user or service technician must access the chamber to clean or maintain the drive components, which increases the risk of additional contamination.By performing maintenance work in the chamber, the service technician also exposes himself to a risk of contamination / infection, as the chamber itself may be contaminated.

[0009] The present invention is therefore based on the objective of providing a laboratory shaker that is easy and safe to maintain.

[0010] The invention solves this problem by means of the laboratory shaker according to claim 1 and the method according to claim 15. Preferred embodiments of the invention are the subject of the dependent claims and will become apparent from the present description of the invention and the figures.

[0011] The arrangement of drive components on a drawer according to the invention results in optimal accessibility of all drive parts for maintenance purposes. The good accessibility of the drive can also be used to change a mixing orbit. The arrangement of the drive components on a drawer according to the invention makes it particularly possible to pull the drive components forward out of the device. This is an aspect of the good accessibility, because the laboratory device, especially the laboratory shaker, does not have to be moved from its location to access the drive components. Usually, several laboratory shakers are stacked on top of each other to make the most efficient use of the limited laboratory space. A single device – without culture vessels – typically weighs between 150 kg and 190 kg, and a stack of two or three devices thus weighs between 300 kg and 380 kg, or between 450 kg and 570 kg, respectively.A clear advantage of the solution according to the invention is that it avoids the need to move heavy individual devices or stacks of devices for maintenance work. The laboratory shaker according to the invention is therefore, in particular, an ergonomic laboratory device.

[0012] This allows the user or technical service to modify the drive's application range in the field – different orbits ensure optimal mixing of various sample containers. The design according to the invention also simplifies the adjustment of the imbalance compensation on rotating drive components mounted on the drawer element. In static imbalance correction, an additional mass is either added to or removed from one or more specific locations on the rotating component to correct the imbalance.

[0013] The platform assembly is removable, in particular from the interior of the chamber. The platform assembly is mountable to and detachable from at least one drive component, in particular a transmission device, especially a transmission plate, which transmits the shaking motion from the drive device to the platform assembly. For this purpose, at least one connecting element is provided, which detachably connects the platform assembly, in particular a sub-platform of the platform assembly, to the drive component, in particular the transmission device, in particular a transmission plate. The at least one connecting element can be designed for tool-free assembly or detachment of this connection; however, assembly with tools is also preferred.The at least one connecting element may include a screw with a screw head having a suitable contour for positive locking with the tool, or a screw with a hand-operated rotating head, with a locking device or with a quick-release device.

[0014] The transmission device preferably comprises at least one transmission element, in particular a transmission plate, which is especially a component of the drive device to which the platform device is detachably connected and through which, in particular, the shaking motion is transmitted to the platform device. The transmission element can also be a frame device, in particular a rack device. The transmission device can have several transmission elements that support the transmission of the shaking motion to the platform device.

[0015] The platform assembly may include a sub-platform which is connected and / or connectable to the drive component, in particular the transmission plate, by means of at least one connecting means.

[0016] The platform assembly can include a support platform for carrying the sample containers to be shaken within the chamber. The support platform can be detachably connected to the sub-platform and can, in particular, be movably mounted on the sub-platform via a rail system.

[0017] The platform assembly is always located in the chamber during operation of the laboratory shaker, i.e., during the shaking motion. The platform assembly is preferably fixed or immovable during operation, but in particular, it is detachably connected to the transmission device.

[0018] The platform assembly can include a rail system by means of which the support platform can be partially, in particular by 40-95%, or completely extended out of the chamber when the chamber door is open. This allows for convenient loading and unloading of the laboratory shaker. Furthermore, it simplifies the disassembly of the platform assembly, especially the sub-platform, from the transmission system. The rail system comprises, in particular, first rail elements mounted on the sub-platform and second rail elements mounted on the support platform. The second rail elements can be mounted on the first rail elements by means of sliding bearings and / or rolling bearings.

[0019] The apparatus space is preferably located below the platform. This allows the apparatus space to be easily separated from the sample space within the chamber, in which the platform and the sample containers are arranged on the platform. The apparatus space can be a space within the chamber. Preferably, the apparatus space is a space outside the chamber, particularly below the chamber. "Below" means "in the direction of gravity," since the laboratory shaker is arranged in its intended operation such that a support platform has a horizontal support area.

[0020] The device compartment is also referred to as the drive compartment, since at least one drive component is located there. However, it is also possible that components not belonging to the drive device are located there, such as electronic components, for example, an electronic control unit for the laboratory shaker. These electronic components can include at least one circuit board.

[0021] The laboratory shaker has a drawer assembly with at least one, preferably exactly one, drawer element—or two, three, four, or more drawer elements—which is movably mounted in the fixture space and to which the at least one drive component is connected and which, in particular, supports this at least one drive component. During operation of the laboratory shaker, the drawer element is preferably detachably connected to a base of the laboratory shaker by means of fasteners, in particular screws, a locking device, or a quick-release device. Before the drawer element is pulled out of the fixture space, this fixed connection created by the fastener must be released.

[0022] The at least one drawer element is movable between a first position, in which the at least one drawer element is arranged in the fixture space, and a second position, in which the at least one drawer element is extended out of the fixture space. Preferably, the drawer assembly is configured such that the drawer element can be pulled out of the fixture space at least 50% in the second position, preferably at least 70%, preferably at least 80%, preferably at least 90%, or preferably at least 95%, or preferably completely. In the latter two cases, the extension is referred to as "full extension".

[0023] Preferably, the laboratory shaker has a base that supports the remaining components of the laboratory shaker. The base is particularly suitable for supporting at least one additional—or several—laboratory shakers if the laboratory shakers are stackable. The drawer element is preferably movably connected to the base and, in particular, movably mounted on the base by means of a guide device, especially a rail system. The guide device is preferably configured to guide the at least one, preferably exactly one, drawer element relative to the base of the laboratory shaker during a translational extension movement.The guide device can have a first guide element, in particular a rail, which is arranged on a first side of the drawer element, and can have a second guide element, in particular a rail, which is arranged on a second side of the drawer element, which is opposite the first side.

[0024] The drawer element can have at least one bearing section by which the drawer element is supported on the device base, in particular a bearing section of the device base. The bearing section can be a component of a plain bearing, but can also include a rolling bearing. The bearing section can, in particular, have one or more plastic elements designed to slide on a plain bearing, in particular a sliding surface, of the device base. The plastic element can be a plate or a membrane. Polycarbonate or POM are, for example, suitable plastics for this purpose.

[0025] Preferably, the drawer assembly comprises a rail system by means of which the at least one drawer element is movably mounted in the fixture space on the device base, in particular by means of a sliding or rolling bearing. The rail system comprises, in particular, first rail elements mounted on the device base and second rail elements mounted on the drawer element. The second rail elements can be mounted on the first rail elements by means of sliding and / or rolling bearings.

[0026] Preferably, the drive device includes a drive unit, in particular an electric motor, which is rigidly connected to the device base, in particular by positive locking, force locking, and / or material locking. In this case, the drive unit is not mounted on the drawer element and is therefore not moved out of the fixture space of the laboratory shaker when the drawer element is moved from the first to the second position.

[0027] The drive device can also include a drive unit, in particular an electric motor, which is rigidly connected to the at least one drawer element, in particular by positive locking, force locking, and / or material locking. In this case, the drive unit is mounted on the drawer element and is therefore also moved relative to the device base, in particular moved out of the device space when the drawer element is moved from the first to the second position.

[0028] Preferably, the at least one drive component includes a pulley that is coupled to the drive unit via a belt, which is arranged in particular next to the drawer device.

[0029] Preferably, the drive unit is a direct drive. The output shaft of the direct drive is preferably coaxially connected to a drive disc, in particular an eccentric disc, in order to drive it—especially without the use of a gearbox. In this case, the drive unit is preferably arranged on the drawer element. The drive unit can be a flat electric motor whose height is less than its width and / or depth. In particular, the drive unit can be a disc-shaped motor, especially a disc rotor motor.

[0030] The drive disc preferably has a transmission element that is arranged eccentrically to the axis of rotation of the drive disc and that, in particular, causes the shaking motion. The transmission element preferably connects the drive disc to the transmission device.

[0031] Preferably, the at least one drive component has one or more movable base parts, also referred to as bearing elements or idlers, which are connected in particular to the at least one drawer element and in particular to the transmission device or the transmission plate.

[0032] An idler is specifically designed to support the platform mechanism, which is driven by the eccentric disc and performs an orbital motion. The idler does not have an active drive function; rather, it serves to stabilize and support the transmission mechanism while it is driven by the eccentric.

[0033] The idler is typically located at a point along the path of the transmission device and helps to stabilize and guide the lateral movement while the platform device performs the shaking motion. It helps to reduce the stress on the transmission element and drive components, thus extending the system's service life.

[0034] In summary, the at least one idler supports the transmission device and thus the platform device by ensuring stable guidance along the path of the orbital motion and stabilizing the eccentric movement of the eccentric.

[0035] Preferably, the drive device comprises a drive unit configured to provide a drive motion and a gear unit configured to convert the drive motion into the shaking motion, the gear unit comprising at least one gear element. The drive unit and the at least one gear element are drive components, at least one of which is connected to the at least one drawer element. The drive motion is, in particular, a rotational motion of the output shaft of an electric motor. The shaking motion of the platform device is such that all points on the platform device move integrally in a common, planar, orbital path, defined as the superposition of two translations and with an eccentricity.

[0036] The transmission unit includes, in particular, those moving components that are located in the kinematic chain between the drive unit and the connecting elements that connect the platform unit to the drive device.

[0037] Preferably, the chamber is bounded by a chamber floor wall, which separates the interior of the chamber from the device space preferably provided below the chamber floor wall and which is designed to couple the drive device with the platform device, in particular by having at least one floor opening, in particular several floor openings, preferably two, three or preferably four floor openings.

[0038] Preferably, the chamber is bounded by a chamber floor wall. Preferably, the laboratory shaker has at least one connecting element, in particular a coupling rod, by which the platform assembly is detachably connected to the at least one drive component. The connection by this connecting element is preferably positive-locking and / or friction-locking. Preferably, the at least one connecting element extends through at least one opening in the chamber floor wall when the platform assembly is connected to the at least one drive component. Preferably, several openings are provided in the floor, each through which exactly one connecting element extends.

[0039] Preferably the shaking movement runs parallel to the chamber bottom wall, i.e., in particular horizontally, wherein at least one bottom opening of the chamber bottom wall is preferably dimensioned in such a way that the relative movement of the connecting element and the chamber bottom wall corresponding to the shaking movement is enabled.

[0040] Preferably, the at least one bottom opening is sealed by a sealing element arranged between the chamber bottom wall and the connecting element. Preferably, each bottom opening is sealed by a sealing element, which is arranged, in particular, between the chamber bottom wall and the connecting element.

[0041] Preferably, the sealing element is connected to the connecting element, but preferably not to the chamber bottom wall, or preferably also to the chamber bottom wall. The connection is preferably force-fit and / or form-fit and / or material-fit.

[0042] Preferably, the connecting element and / or a drive component, in particular the transmission device, has at least one connecting means, in particular a screw or long screw, which is guided in particular through a central bore in the connecting element, or a locking or quick-release device. The connecting element is preferably detachably connected to the drive component, in particular the transmission device, by means of the at least one connecting means, particularly while the bottom opening is sealed by the sealing element.

[0043] Preferably, the connecting element has a thread which is designed to create a screw connection between the connecting element and the transmission device and which is arranged in particular concentrically to a central longitudinal axis of the connecting element.

[0044] Preferably, the at least one drive component, in particular a gear element, comprises the transmission device, in particular a transmission plate, for supporting the platform device. The at least one connecting element can be connected to the transmission device.

[0045] In particular, the transmission device is connected to the at least one drawer element when it is moved between the first and second positions.

[0046] The invention also relates to a method for actuating the drawer device, in particular for maintaining the drive device of a laboratory shaker according to the invention, comprising the steps: Removing the platform device from the chamber; Optional: Disconnecting the at least one drive component and the at least one connecting element, which extends through at least one bottom opening in the chamber floor wall to connect the platform device and the at least one drive component, which is preferably sealed by at least one sealing element during the disconnection of the connection; Optional: Detaching the at least one sealing element from the connecting element and / or the chamber bottom wall; Optional: Detaching the at least one drawer element detachably connected to the device base; Moving the at least one drawer element, which carries the at least one drive component, from the first position in which the drawer element is arranged in the device space, to a second position in which the drawer element is at least partially and / or maximally extended from the device space; Preferably: Maintaining the at least one drive component, in particular including at least one of the following maintenance steps: o Adjusting the drive device, in particular changing the size of an orbit of the shaking motion, ∘ Changing an imbalance compensation of a rotating drive component, in particular the drive pulley; ∘ Replacing a drive component, in particular a drive belt; ∘ Cleaning drive components;Optional: Moving the at least one drawer element, which carries the at least one drive component, back from the second position to the first position. Optional: Securing the at least one drawer element to the device base, in particular by screwing it in place.

[0047] Preferably, the chamber bottom wall has at least one bottom opening which is closed by a sealing element. Preferably, the laboratory shaker has at least one connecting element which connects the at least one drive component to the platform assembly and which extends through the at least one bottom opening and the sealing element.

[0048] The sealing elements create a chamber interior free of drive components, making it easy to clean. Despite the thermal weak points created by the chamber bottom openings, the sealing elements prevent excessively cool surface temperatures on the chamber bottom wall, which would lead to condensation. The sealing elements also contribute to the low overall height of the laboratory shaker, as the chamber interior can be optimally utilized even with large sample vessels. This low height is particularly advantageous for stacked shakers, as the upper units must also remain ergonomically accessible. Furthermore, optimal height utilization is crucial for devices designed for higher throughput or optimal protein yield during expression in suspension cells.

[0049] The two preferred technical concepts for sealing elements with sliding bearings do without an elastomer part firmly connected between the chamber bottom wall and the connecting element in order to counteract the wear of the elastomer under its high load caused by continuous shaking motion.

[0050] Preferably, the sealing element comprises or consists of an elastomeric material, in particular a silicone material, preferably platinum-crosslinked silicone, or a fluororubber.

[0051] Preferably, the sealing element is a flat component whose maximum extent in directions parallel to the chamber floor wall is greater than its maximum extent measured perpendicular to the chamber floor wall.

[0052] Preferably, the sealing element has a through-channel, particularly a central one, with a through-opening, through which the connecting element passes and against which the connecting element fits tightly, and / or wherein the sealing element is mounted and / or fastened to the connecting element. Preferably, the through-channel is axial, and its wall thickness is greater than the thickness of a radially extending wall of the sealing element.

[0053] Preferably, the connecting element has at least one fastening section along its longitudinal axis A, the latter having a radial extension that varies. Preferably, the sealing element, in particular its passage channel, contacts this fastening section and encloses it, in particular in a form-fitting manner.

[0054] Preferably, the sealing element is movably mounted on the chamber bottom wall by means of a sliding bearing device, wherein i) preferably the sliding bearing device has a sliding surface extending parallel to the chamber bottom wall; ("axial sliding bearing") or alternatively, ii) preferably the sliding bearing device has a sliding surface not extending parallel or perpendicular to the chamber bottom wall; ("radial sliding bearing")

[0055] Preferably, the sealing element is a cap element, particularly a disc-shaped one, that covers the chamber bottom opening, especially during the operation of the drive device. This is particularly useful for the sliding bearing of the sealing element.

[0056] Preferably, the connecting element terminates below an imaginary plane, which is preferably located within the chamber and runs parallel to the chamber floor wall at a distance h, where preferably h ≤ 10 cm, preferably h ≤ 5 cm, and preferably h ≤ 3 cm. This allows the platform device to be positioned near the chamber floor, thus optimizing the use of the chamber interior space.

[0057] Preferably, the longer part of the connecting element, measured along its longitudinal axis A, is arranged outside the chamber and below the chamber floor wall. This allows for a short distance between the platform device and the chamber floor wall, and optimizes the use of the chamber interior space.

[0058] Preferably, the sealing element is attached to the connecting element and configured to slide along a sliding surface parallel to the chamber bottom wall during the shaking motion. This sliding surface is provided at the chamber wall opening, particularly in the form of a circular ring around it. This concept is referred to as axial sliding bearing. Preferably, the sealing element has a sealing ring section extending parallel to the planar sliding surface and around the chamber wall opening, which is in contact with the sliding surface during sliding.

[0059] Preferably, the sealing element is flat and in particular has a sliding plane which runs substantially parallel to the chamber bottom wall, wherein preferably the sealing element anchored to the connecting element is arranged to compensate for inclination deviations between the sliding plane and the flat chamber bottom wall by means of a mobility of the sealing element, in particular by the sealing element having at least one elastically deformable, in particular annular, section or being completely elastically deformable.

[0060] Preferably, the connecting element and / or the drive component has at least one connecting element, in particular a screw, especially a long screw, which is guided through a central cavity or through-channel in the connecting element. Preferably, the connecting element is detachably connectable to the drive component, particularly when the bottom opening is sealed by the sealing element. Preferably, the connecting element includes a thread designed to create a screw connection between the connecting element and the drive component, and which is arranged, in particular, concentrically to a central longitudinal axis of the connecting element.

[0061] Preferably, a transmission device, in particular a transmission plate, for supporting the platform device is arranged on at least one drive component, in particular a gear element, and the at least one connecting element is connected to it. This gear element, in particular the transmission device, is preferably arranged outside the chamber.

[0062] Preferably, an insulating layer made of a thermally insulating material is arranged below the chamber, adjacent to or adjoining the chamber bottom wall or the heating coil preferably located there. This insulating layer particularly has an opening through which the connecting element passes. The opening is preferably concentric with the chamber bottom opening. Preferably, an insulating element connected to the connecting element is provided, which is movable relative to the insulating layer together with the connecting element and which covers or closes the opening in the axial direction, particularly also during shaking.

[0063] Preferably, the laboratory shaker has a heating device, which in particular includes heating coils - preferably on the outside of the chamber - and an electrical control device programmed to execute a high-temperature program by which the control device is programmed to heat the chamber interior, sealed by the at least one sealing element, to a predetermined temperature for a predetermined period of time by means of the heating device, wherein the period can be between 1 minute and 12 hours, in particular between 20 minutes and 5 hours, and wherein the temperature can be between 90 °C and 140 °C, preferably up to 180 or 200 °C.

[0064] The invention also relates to a method for treating the interior of a laboratory shaker according to one of the preceding claims, comprising a heating device and an electrical control device programmed to execute a high-temperature program, by which the control device is programmed to heat the interior of the chamber, sealed by the at least one sealing element, to a predetermined temperature by means of the heating device for a predetermined period of time, wherein the period can be between 1 minute and 12 hours, and wherein the temperature can be between 90 °C and 140 °C, the method comprising the step of: Heating the interior of the chamber by means of the heating device to a predetermined temperature for a predetermined period, wherein the period can be between 1 minute and 12 hours, and wherein the temperature can be between 90 °C and 140 °C, preferably up to 180 or 200 °C.

[0065] Preferably, the sealing element has at least one eccentric disc and, in particular, a sliding surface with a radial orientation.

[0066] Preferably, the sealing element has at least one eccentric disc which has at least one sliding surface with a radial orientation, in particular with an orientation radially outwards.

[0067] Preferably, the sealing element has at least one first eccentric disc, which has at least one sliding surface with a radial orientation, in particular with an orientation radially outwards, and preferably the sealing element has at least one second eccentric disc, which has at least one sliding surface with a radial orientation, in particular with an orientation radially outwards. This arrangement is also referred to as a double eccentric disc. The connecting element is preferably rotatably mounted eccentrically about its longitudinal axis in the second eccentric disc, preferably by means of a spherical bearing.

[0068] Preferably, the sealing element has a sealing ring section that runs parallel to the sliding surface, which is perpendicular to or at least inclined relative to the chamber bottom wall and runs concentrically to the chamber wall opening, and which is in contact with the sliding surface when sliding.

[0069] Preferably, the sealing element is flat and has a main plane that runs substantially parallel to the chamber bottom wall, wherein the sealing element anchored to the connecting element has at least one elastically deformable, in particular annular, section or is completely elastically deformable.

[0070] Preferably, the sealing element has magnetic sections whose magnetic attraction pulls the sealing element towards the chamber bottom wall.

[0071] Preferably, a radial sliding surface is provided on an annular insert element, in particular a bearing sleeve, which is attached to the chamber wall opening and in particular projects into it.

[0072] Preferably, the sealing element has a curved wall section, which is designed in particular as an annular trough, in the center of which a passage channel or opening is provided for the passage of the connecting element.

[0073] Preferably a retaining ring element is provided with which the sealing element is attached to the chamber bottom opening, and which extends in particular with a hollow cylindrical section towards the device space.

[0074] The laboratory shaker for shaking laboratory samples is specifically designed for temperature control. Such devices are electrically operated and have a power connection. The laboratory shaker maintains the temperature of the laboratory samples; that is, it keeps the interior of the housing, and thus the laboratory samples stored there, at a set temperature, within tolerances, by means of temperature control. This temperature can be above room temperature (ambient temperature), as is the case with a heating cabinet or incubator, or below room temperature, as is the case with a refrigerator or freezer. In a laboratory shaker designed as a climate-controlled shaker, a climate parameter prevailing inside the housing is preferably also regulated within tolerances. This climate parameter can be the humidity and / or a gas concentration, e.g., CO2, O2, and / or N2 concentration.Such a climate laboratory shaker is, for example, a laboratory shaker for shaking laboratory samples, especially with living cell cultures, with incubator function, also referred to as an incubation shaker.

[0075] Typical features of such laboratory shakers may include one or more of the following: Chamber temperature controllability: Heating to a maximum of 60°C, or 80°C for cell culture. Shaking speed range: (25-500, -1000 rpm). Housing format suitable for laboratory placement (on the lab bench, under the lab bench, stackable floor-standing models). Stackability of the housing (2, 3, or more stacked). Capacity and throughput: Vessel type, size, and capacity. Loading method (front or top). CO2 control. Photosynthetic light.

[0076] The laboratory shaker is particularly preferably configured to perform a high-temperature sterilization process inside the chamber using a temperature control device and / or a heating device. In this process, the chamber is exposed to a temperature between 150°C and 200°C, preferably at least 180°C, for a period ranging from several seconds (e.g., 1, 2, 5, 10, 30 seconds) to several minutes (e.g., up to 1, 2, 3, 5, 10, 30, 60, 120, 240, 480, or 600 minutes), without the need to remove the extraction mechanism, preferably including the attached sample platform. The laboratory shaker, and in particular an electronic control device that controls the temperature control device and / or the heating device, is particularly preferably configured to maintain the temperature of the chamber for a period exceeding one hour, and especially for a period of several hours.The chamber is to be exposed to a target temperature between 150°C and 200°C, preferably at least 180°C, for a period of time within an interval of 2, 3, 4, 5, 6, 7, 8, 9, or 10 hours. The chamber typically requires a heating period to reach the target temperature and a cooling period to cool back down to a normal operating temperature. In particular, the extraction mechanism is located within the sealed chamber during the high-temperature cycle. The extraction mechanism and the sample platform are made of a suitably high-temperature-resistant material, in particular stainless steel or aluminum, especially anodized aluminum.

[0077] The laboratory shaker preferably has a housing. The housing is preferably an outer housing whose walls are in contact with the environment. The housing door can accordingly be an outer housing door that, in the closed position, borders the environment.

[0078] The housing door has, in particular, a hinge mechanism that pivots the housing door to the housing. Such a hinged door is moved between an open and a closed position by rotation. The hinge mechanism can be located, in particular, on the vertically oriented outer edge of a cuboid housing, adjacent to the housing opening, as is typical for the laboratory shaker in normal use. The base plate of a cuboid housing is arranged horizontally in normal use, the side walls of the housing are arranged vertically, and the top plate of the housing is arranged horizontally opposite the base plate.

[0079] A data processing unit is preferably part of the electrical control unit that controls the functions of the laboratory shaker and which the laboratory shaker preferably includes. The functions of the control unit are implemented, in particular, by electronic circuits. The control unit can include a microcontroller, a processing unit (CPU) for processing data, and / or a microprocessor, each of which can incorporate the data processing unit. The control unit and / or the data processing unit is preferably configured to carry out a control method, also referred to as control software or a control program. Such a control method can define the timing of a shaking motion that can be performed by means of the shaking device.This shaking motion is defined in particular by the direction(s) of translational movements and / or the amplitude(s) of successive movement segments performed in an xy-plane. This xy-plane is generally parallel to the sample platform and / or a chamber floor. Preferred diameters of a shaking motion performed in an xy-plane are between 0 and 5.08 cm (2 inches) or up to 7.62 cm (3 inches). The shaking device, in particular an orbital drive, is preferably configured for a shaking motion with a maximum diameter between 0 and 5.08 cm (2 inches) or up to 7.62 cm (3 inches). The functions of the laboratory shaker and / or the control device can be described in process steps. They can be implemented as components of the control program, in particular as subprograms of the control program.

[0080] Preferably, the laboratory shaker is an incubation shaker. The incubation shaker can then also be operated as a laboratory incubator and is thus a device with which controlled climatic conditions can be created and maintained for various biological development and growth processes. It serves in particular to create and maintain a microclimate with regulated gas, humidity, and / or temperature conditions in the chamber, whereby this treatment can be time-dependent.The incubation shaker may in particular have a timer, especially a time switch, a temperature control device designed as a heating and / or cooling device and preferably a setting for regulating an exchange gas supplied to the chamber, an adjustment device for the composition of the gas in the chamber of the incubation shaker, in particular for adjusting the CO 2 and / or the O 2 and / or the N 2 content of the gas and / or an adjustment device for adjusting the humidity in the chamber of the incubation shaker.

[0081] The incubation shaker comprises, in particular, the incubator chamber (=chamber), and preferably a control device with at least one control loop, to which at least one temperature control device is assigned as the actuator and at least one temperature sensor as the measuring element. Depending on the embodiment, the humidity can also be controlled via this device, with the humidity preferably being measured by a humidity sensor (rH sensor) in the chamber, and the humidity being, in particular, the input variable of the control loop. For humidifying the chamber, a water-filled tray can be provided in the incubator chamber, which can be heated or cooled to adjust the humidity via evaporation. However, it is more preferred to provide an evaporator device on the outside of the chamber, which generates steam as needed and supplies it to the chamber through a steam inlet opening in the chamber wall.This steam supply is preferably regulated by the control unit. CO₂ incubation shakers are used in particular for the cultivation of animal or human cells.

[0082] The control device can be configured to automatically select a program parameter or a control parameter of the laboratory shaker, particularly the incubation shaker, based on other data. In the case of an incubator, treatment of at least one cell culture in at least one cell culture container controlled by a control parameter corresponds specifically to climate treatment to which the at least one cell culture is subjected.Possible parameters, in particular program parameters, in particular user parameters, which are used to influence a climate treatment, define in particular the temperature of the chamber in which the at least one sample is incubated, the relative gas concentration of O 2 - and / or CO 2 and / or N 2 in the chamber, the humidity in the chamber and / or at least one process parameter that influences or defines the process, in particular the sequence, of an incubation treatment program and / or shaking program consisting of several steps.

[0083] The temperature control device can be a combined heating / cooling device. Preferably, it is solely a heating device. This heating device can, in particular, generate heat via an electrical resistance wire. Preferably, the resistance wire is attached to the outside of at least one, several, or all of the chamber walls that form the chamber.

[0084] Laboratory shakers, or incubation shakers, can have a single chamber or multiple chambers, the atmosphere of which (temperature, relative gas concentration, humidity) can be individually or collectively adjusted. A typical chamber volume ranges from 50 to 400 liters, although smaller chamber sizes, particularly 10 to 49 liters, are available for specific applications (IVF).

[0085] Further preferred embodiments of a laboratory shaker according to the invention can be found in the description of the exemplary embodiments according to the figures. The same reference numerals denote essentially identical components.

[0086] They show: Fig. 1a shows a perspective side-frontal view of a laboratory shaker according to the invention and an exemplary embodiment. Fig. 1b shows the laboratory shaker of Fig. 1a , with a removed side wall and the components arranged laterally in an electronics chamber. Fig. 1c shows the laboratory shaker of Fig. 1a , with the swing door open, the sealing elements, connecting elements, sub-platform and platform as well as sample vessels removed from the chamber and therefore not shown. Fig. 1d shows the laboratory shaker of Fig. 1c , with the front panel removed, behind which the drive chamber, located below the chamber, is situated. Fig. 1e shows in a perspective view a detail of the laboratory shaker of the Fig. 1d . Fig. 1f shows a cross-sectional view of the laboratory shaker of the Fig. 1d . Fig. 1g shows the laboratory shaker of Fig. 1d , with the drive drawer pulled out. Fig. 1h shows the laboratory shaker of Fig. 1g , with the transfer plate removed. Fig. 1i shows a perspective side-frontal view of a laboratory shaker according to the invention in a further embodiment. Fig. 1j shows in a perspective view a detail of the laboratory shaker of the Fig. 1i . Fig. 2a The figure shows, in perspective, a connecting element equipped with a cap-shaped sealing element, which is used with the laboratory shaker of the Fig. 1a bis 1d usable. Fig. 2b shows a cross-sectional view of the connecting element provided with the cap-shaped sealing element of the Fig. 2a , cut through the central longitudinal axis A of the connecting element. Fig. 3 shows the connecting elements equipped with the cap-shaped sealing element of the Fig. 2a und Fig. 2b , which is mounted on a drive component of the laboratory shaker formed as a transmission plate Fig. 1a bis Fig. 1d are mounted, although the sub-platform and platform equipment inside the chamber are not shown. Fig. 4 shows the laboratory shaker of Fig. 2a , with the swing door open, in a cutaway view in which the laboratory shaker is shown cut parallel to a side wall and through the central longitudinal axes of two connecting elements.

[0087] Fig. 1a Figure 1 shows a perspective side-frontal view of a laboratory shaker 1 according to the invention. It is a CO2 incubation shaker, particularly a stackable one, which implements a method according to the invention for high-temperature disinfection of the chamber interior. The chamber interior 3 of the laboratory shaker has a capacity of 220 l (usable volume), with an overall low overall height of the laboratory shaker. This is made possible in particular by the fact that the sealing elements between the drive chamber 4 (also: device chamber 4) and the chamber interior 3 are designed in a flat construction, so that the height H (dimension in the z-direction, i.e., vertically in the intended use of the laboratory shaker) of the sealing elements is smaller than their width B (x-direction) and / or length L (y-direction), so that preferably H < c * B and H < c * L, where c can be: 1; 0.75; 0.5; 0.25; 0.2; 0, 1, depending on the design of the sealing element.

[0088] Particularly preferred is the embodiment of the sealing element 50 with an axial sliding bearing, which is located in the Figuren 1a bis 1c as in Fig. 3 and 4 shown.

[0089] The laboratory shaker 1 has a housing 19 in which the chamber 2 is arranged. When the swing door 10 is closed, the chamber opening 2a of chamber 2 is sealed by means of a door seal 10a and sealing elements 50, 50', etc., such that during operation of the laboratory shaker 1, only a negligible exchange of gases or water vapor occurs between the chamber interior 3 and the environment of the laboratory shaker. The drive 20 of the laboratory shaker is arranged outside the chamber 2. This allows for efficient use of the chamber interior 3; in particular, the drive components are not heated during a high-temperature sterilization process applied to the chamber interior. The swing door has a viewing window 12, which is designed as a double-walled glass plate.

[0090] In particular, a large part of the drive is located in the device compartment 4, also referred to as drive compartment 4, which is situated below the chamber floor 31. Part of the drive 20, as well as other components, are located in the electronics compartment 5, which is situated to the side of the chamber. The housing 19 has a side wall 7, another side wall (not shown), a rear wall (not shown), a front panel 6, and a side panel 8. The hinged door 10 can be pivoted upwards from the front wall plane by a pivoting mechanism 15 with a gas spring; the open position of the hinged door is shown in Fig. 1c und 1d shown.

[0091] Fig. 1b Figure 1 shows the laboratory shaker 1 with a removed side panel 7 and the components arranged laterally within an electronics compartment 5. These components include the drive 20, here a BLDC motor, the driven belt 21, the power supply components 22 for the drive and the heating element for heating the chamber, with fan 23, and an electronic circuit board 24, which in particular contains the control unit of the laboratory shaker. This control unit is specifically programmed to execute a high-temperature sterilization process applied to the chamber interior 3, according to one aspect of the invention. Also visible is the water evaporator 25, with which water can be evaporated and introduced into the chamber interior.

[0092] Fig. 1c Figure 1 shows the laboratory shaker 1 with the swing door 10 open, the sealing elements, connecting elements, sub-platform and platform, as well as sample containers, having been removed from the chamber and therefore not shown. Visible is the chamber 2, which is formed from integrally joined stainless steel walls 31, 32, 33 (a stainless steel chamber is preferred, but aluminum as a chamber material is also preferred), which are connected to each other by curved wall sections. These chamber walls include the chamber bottom wall 31, the side wall 32, another side wall (not shown), a ceiling wall (not shown), and a rear wall 33. The chamber bottom wall 31 has four bottom openings 35. Concentric to each bottom opening, an annular sliding surface element 36 made of stainless steel is mounted concentrically around the bottom opening and on the chamber bottom wall 31 in the chamber interior 3.The sliding surface element 36 has on its upper side the sliding surface 37 arranged (with tolerances) parallel to the chamber bottom wall. This serves for the sliding bearing of a sealing element 50 (in . Fig. 1c, d not shown, see Fig. 2a, 2b ), which is arranged for axial sliding support on the sliding surface.

[0093] If the drawer element 40 needs to be pulled out for maintenance purposes, the laboratory shaker must be in Fig. 1c The removable front panel 6 is removed and the screw connections are loosened by which the drawer element 40 is connected to the device base 9 during operation, especially during shaking operation. This provides access to the Fig. 1d depicted state of the laboratory shaker.

[0094] Fig. 1d shows the laboratory shaker of Fig. 1c With the front panel 6 removed, the drive compartment 4, located below the chamber, is situated behind it. A drawer element 40, in this case a drawer plate 40, is arranged in the drive compartment 4. A plastic plate is fixedly mounted to the underside of this drawer plate as a sliding section. The drawer plate is thus supported by the sliding section. The translational extension movement is guided by the guide device 43, which is fixedly connected to a base 9 of the laboratory shaker 1 during operation. For maintenance purposes, the drawer plate can be pulled forward (in the y-direction) out of the drive compartment 4. Alternatively, a rail system (not shown) could be used, the rails of which support the drawer plate.

[0095] On the drawer plate 40, the eccentric disc 41, driven by the belt 21 and equipped with an eccentric coupling 46, is rotatably mounted. This disc sets the drive component, designed as a transmission plate 44 (not visible here) and located above (i.e., in the positive z-direction) the drive disc 41, into a horizontal shaking motion. Four movable base parts (bearing elements, idlers) 42, in particular with a double ball-bearing eccentric shaft, wherein an upper ball bearing is elastically mounted, are mounted on the drawer plate 40. These base parts support the transmission plate 44, and its horizontally movable bearing mechanisms follow the horizontal shaking motion generated by the drive disc 41 through the eccentric coupling.

[0096] The drawer assembly comprises the drawer element 40 and the guide rails 43, on which the drawer element 40 is movably mounted, here for a sliding translational movement between a first and a second position. In the exemplary embodiment of the laboratory shaker 1, the drawer element 40 can be pulled forward out of the drive compartment 4 after loosening some screws that firmly connect the drawer plate 40 to the device base 9 in the operating state. In doing so, the drawer element 40 is moved from a first position, which is located in Fig. 1d shown, in which the drawer element 40 is arranged in the drive compartment, moved into a second position, which is in Fig. 1g The figure shows that at least one drawer element 40 has been extended from the drive compartment 4. Accordingly, the drawer element 40 can be moved from the second position back to the first position, particularly after the maintenance personnel have performed the desired action on the drive device 41, 42, 21.

[0097] "Forward" refers to the direction perpendicular to the outside from door 10 of the laboratory shaker, i.e., the y-direction as in Fig. 1a shown.

[0098] Fig. 1e shows a detail of the in the Figur 1d 1. If, for maintenance purposes, in particular for replacing (drive) components, especially the belt 21, the idler 42, or for changing the unbalance mass or the orbit, the drawer element 40 is to be pulled out, the belt 21 must be loosened in this state by releasing the impeller assembly 45 and removed from the motor drive wheel of the motor 20. If necessary, one or more cables must be disconnected.

[0099] Fig. 1f shows a cutaway view of a detail of the laboratory shaker of the Fig. 1d , in which the drawer element 40 is fully visible.

[0100] Fig. 1g shows the laboratory shaker of Fig. 1d With drawer 40 pulled out, the transfer plate 44 must be removed by loosening a few screws to access the eccentric disc 41. Since the drawer is pulled out, this and all other maintenance measures can be carried out conveniently.

[0101] Fig. 1h shows the laboratory shaker of Fig. 1g , with the transmission plate 44 removed. The belt 21 can now be easily replaced, for example. The orbit can also be conveniently changed by repositioning the coupling piece 46 on the pulley 41 or by inserting a drive pulley with a different eccentricity and different idlers 42, as can the imbalance compensation on the mass exchange device 41a, which is rigidly connected to the drive pulley 41 to compensate for the imbalance caused by the shaking of the platform device.

[0102] Fig. 1i Figure 1 shows a perspective side-frontal view of a laboratory shaker 1' according to a further embodiment of the invention. The components of the laboratory shaker 1 are identical. Fig. 1a and the laboratory shaker 1' of the Fig. 1i They have the same reference symbols, so a further description is unnecessary.

[0103] Fig. 1j shows in a perspective view a detail of the laboratory shaker 1' of the Fig. 1i In contrast to the drive unit 20 of the laboratory shaker 1 of the Fig. 1a The drive unit 20' of the laboratory shaker 1' is mounted on the drawer element 40', specifically on the cantilever element 40a', which is rigidly connected to the drawer element 40' laterally to the drive pulley 41' and forms an integral part of the drawer element 40'. When the drawer element 40' is extended from the first to the second position, the cantilever element 40a' with the motor 20' also extends out of the drive compartment. In doing so, it slides along the plate section 9a' of the instrument base.

[0104] Fig. 2a und 2b Figure 1 shows a connecting element 60 equipped with a cap-shaped sealing element 50, which is usable with the laboratory shaker 1. The sealing element 50 is designed for axial sliding bearing on the horizontal sliding surface 37 of the chamber bottom wall 31, wherein the sliding bearing 71 (see below) of the sealing element 50 is supported in axial direction A (vertically) on the sliding surface 37 and thereby also seals the chamber interior 3 from the drive chamber 4. This seal is particularly tight against the passage of gas, vapor, and liquid water. Although the CO2 concentration and the humidity decrease in the chamber over time, they are readjusted. This decrease in concentration depends in particular on the rotational speed.

[0105] The sealing element 50 is a component rotationally symmetrical with respect to the longitudinal axis A, comprising a body 51, 52 formed by injection molding from platinum-cured silicone or another elastomer. This body is formed by a centrally and axially extending through-channel 51, from which a cover wall section 52 extends radially downwards in a cap-like manner. The wall thickness of the through-channel 51 is greater than the wall thickness of the cover wall section 52. The radial dimensions of the cover wall section 52 are such that the bottom opening 35 remains covered and sealed by the sealing element 50 during all intended movements of the connecting element 60. The maximum orbit, i.e., the maximum amplitude of the connecting element 60 in horizontal directions, is 50 mm. This orbit, or smaller orbits, can be selected by the user via the control unit or the user touchscreen 14.

[0106] The sealing element 50 has an annular circumferential groove 54 at its outermost radial position on its underside (the side of the sealing element facing in the negative z-direction). An annular circumferential spring 71 of an annular sliding bearing ring 70, designed for positive engagement with the circumferential groove 54, is inserted into this groove. The sliding bearing ring 70 is thus firmly connected to the body 51, 52 of the sealing element. This connection is such that the sliding bearing, formed by the horizontal sliding bearing surface 71 supported on the sliding surface 37 of the chamber bottom wall, provides a reliable seal between the chamber interior 3 and the drive chamber 4 throughout the service life of the laboratory shaker 1. This effect is made possible in particular by a suitable material pairing of the sliding surface 37 and the sliding bearing ring 70.The sliding surface 37 is polished stainless steel, but can also be diamond-coated, ceramic, or anodized aluminum, and the sliding bearing ring is made of PTFE, but can also be made of PEEK or another abrasion-resistant plastic or composite material.

[0107] The sealing effect achieved by the sealing element 50 arises in particular from the fact that the sealing element is pressed downwards when the sub-platform of the platform assembly, located inside the chamber, is mounted on the connecting elements 60, with the sub-platform bearing axially against the circumferential projection 66 on the outside of the head section 63. Tests showed that a sufficient sealing effect can also be achieved by the self-weight of the sealing element, i.e., in particular without the contact force.

[0108] In the Figuren 2a und 2b The unmounted position of the sealing element is shown, in which the sealing element is placed on the head section 63 of the connecting element 60, but is not yet compressed and instead has its undeformed shape with a total height h. This is reduced here to a mounting height H = 0.9 * h when the sealing element 50 is pressed downwards by the mounted sub-platform. During this assembly, the passage channel 51 is pressed downwards by a distance s = h - H until a stop formed by a circumferential projection 53 on the inside of the passage channel 51 abuts the stop formed by a circumferential projection 67 on the outside of the head section 63 of the connecting element. The diameter of the disc-shaped sealing element 50 is 150 mm, and the height h is 35 mm.

[0109] The contact force, approximately 4-8 N, is generated by the axial elasticity of the cover wall section 52 of the sealing element. This contact force could also be achieved by a compression spring (not used here) positioned between the sub-platform and the sealing element – ​​in this case, the body of the sealing element would not necessarily have to be made of an elastomer. A further advantage of the sealing element 50, made of or using elastomer, is that the elastomer can compensate for any deviation between the chamber bottom wall 31 and the sub-platform 121 from the ideally parallel position of the two plates 31, 121, thus guaranteeing the sealing effect. Such a deviation is typically around 0.5°, but could be compensated for up to approximately 1° to 2°.

[0110] The connecting element 60 is designed here as a one-piece coupling rod. It is made of steel (stainless steel). In this embodiment of the laboratory shaker 1, four of these coupling rods 60 support the entire weight of the platform and its load, particularly during shaking operation, and are also subjected to shear forces in horizontal directions due to the shaking motion. The coupling rod therefore has a widened base section 62, which is integrally connected to the shaft 61 above it and the head section 63 extending upwards from it.

[0111] The connecting element 60 has a through channel 64 that extends through the entire length of the connecting element 60. At its downward end, the through channel 64 has an inwardly projecting circumferential projection 68, which acts as a stop for the screw head of a screw (75, Fig. 3 The screw can be inserted from above into the through-channel 64 and, in particular, into its narrower subsection 64a located in the base section 62, and can thus be securely screwed to the drive component designed as a transmission plate. A pin element 69 on the underside of the base section 62 engages positively in a receptacle on the top side of the transmission plate, preventing rotation of the connecting element 50 about the longitudinal axis A in the mounted position. This mounting device allows maintenance personnel to easily remove the connecting element by accessing the mounting device (through-channel 64, screw 75) via the interior of the chamber 3.After removing the connecting elements 60 (and the sealing elements 50 attached to them), the drawer plate 40 with the drive components arranged on it can be easily pulled forward out of the drive compartment 4 of the laboratory shaker, making the drive easy to service.

[0112] Fig. 3 shows the connecting elements 60 provided with the cap-shaped sealing element 50 of the Fig. 2a und Fig. 2b , which are mounted on a drive component 44 of the laboratory shaker 1 formed as a transmission plate 44, the sub-platform and platform assembly in the chamber interior not being shown. The coupling between the drive and the platform assembly is effected by connecting the coupling rods 60 on the underside of the transmission plate 44 on the one hand by the screw 75 and associated nut, and on the other hand by connecting the sub-platform ( Fig. 4 The platform assembly is connected to the head section 63 of the coupling rod 60. This connection is achieved by screwing the screw element 80 through its external thread 81 into the internal thread 65 formed in the head section 63, thereby clamping the plate of the sub-platform 121 between the stop projection 66 and the underside of the screw head of the screw element 80. The relatively large diameter of the screw head allows the screws to be easily tightened without tools to achieve the necessary coupling strength.

[0113] The heating wires 100 of the heating coil 100 are visible on the underside of the chamber floor wall 31. These wires are in thermal contact with the chamber floor wall and are arranged to create a uniform temperature in the chamber interior 3. This can be achieved either with or without the use of a fan operating in the chamber interior 3. The heating coils are laid with varying surface densities, resulting in a homogeneous temperature distribution and reducing the risk of condensation. Near the chamber opening and at corners, the outer surface of the chamber has a higher density of heating wire per unit area than in planar areas, such as centrally in the planar ceiling wall area or the planar rear wall area. The area of ​​the chamber floor wall 31 below the heating coil is thermally insulated by an insulating foam board 95 (e.g., polyurethane foam).At the positions of the bottom openings 35 of the chamber floor wall 31, the insulating foam panel 95 has through-openings 96 which are concentric to the bottom openings 35 and have the same diameter. It is possible and preferred that insulating plates (not shown here) are arranged above the transfer plate 44 in the area of ​​the connecting elements 60, which thermally insulate the openings 96 of the insulating foam panel 95 in the axial direction even during shaking operation of the platform, while the transfer plate 44 with the insulating plates moves relative to the insulating foam panel 95.

[0114] Fig. 4 shows the laboratory shaker 1, with open swing door 10, in a cut view, in which the laboratory shaker is shown cut parallel to a side wall and through the central longitudinal axes of two connecting elements 50.

[0115] Fig. 4 The figure shows in particular the platform assembly 120, which is supported by the connecting elements 60 mounted on the transmission plate 44 of the drive. The sub-platform 121 is clamped between the mounting screws 80 and the coupling rods 60.

[0116] The platform assembly 120 includes the sub-platform 121, an essentially plate-like component that extends parallel to the chamber floor wall 31 inside the chamber. The platform assembly has a rail-based extension mechanism (not shown) by means of which the main platform 122, which is mounted on the sub-platform 121 by rails, can be pulled forward (in the y-direction) out of the chamber interior when the pivot door 10 is open. For this purpose, the pivot lever 124 is first tilted forward by 90°, which releases a locking mechanism (not shown) of the main platform 122 on the sub-platform and makes the main platform movable along the y-axis. A cover plate section 123 is detachably mounted on the main platform 122 to serve as a support platform. The cover plate section 123 is in the locked position of the main platform (in Fig. 4(shown) attached to the main platform 122. Holders for holding eight Erlenmeyer flasks 130 are mounted on the cover plate section 123. Alternative cover plate sections with holders for other sample vessels can be used optionally.

Claims

1. Laboratory shaker (1) for shaking biological samples stored in sample containers (130), comprising a platform device (121; 122) on which the sample containers can be stored, which can be shaken by means of a shaking motion and which is arranged in a chamber (2) of the laboratory shaker, which has a closable chamber opening (2a), a drive device (20; 21; 40; 41; 42; 43; 44; 45; 46) designed to carry out the shaking motion, which has at least one drive component (44), and a device space (4) provided below the platform device. characterized by the fact thatThe laboratory shaker has a drawer device (40, 43) with at least one drawer element (40) which is movably mounted in the device space (4) and with which the at least one drive component (44) is connected, wherein the at least one drawer element (40) is movable between a first position in which the at least one drawer element is arranged in the device space (4) and a second position in which the at least one drawer element (40) is at least partially extended out of the device space (4).

2. Laboratory shaker according to claim 1, comprising a device base (9) which supports the laboratory shaker, wherein the drive device includes a drive unit (20), in particular a motor, which is rigidly connected to the device base.

3. Laboratory shaker according to claim 1, wherein the drive device includes a drive unit (20), in particular a motor, which is rigidly connected to the at least one drawer element (40).

4. Laboratory shaker according to one of the preceding claims, wherein the drive device comprises a drive unit (20) configured to provide a drive movement and a gear unit (21; 45; 41; 46; 44) configured to convert the drive movement into the shaking movement, which comprises at least one gear element (21; 45; 41; 46; 44), wherein the drive unit (20) and the at least one gear element (21; 45; 41; 46; 44) are drive components, at least one of which is connected to the at least one drawer element (40).

5. Laboratory shaker according to one of the preceding claims, wherein the chamber (2) is bounded by a chamber bottom wall (31) which separates the interior (3) of the chamber from the device space (4) provided below the chamber bottom wall (31) and wherein the chamber bottom wall is configured for coupling the drive device with the platform device.

6. Laboratory shaker according to one of the preceding claims, the chamber (2) of which is bounded by a chamber bottom wall (31) and which has at least one connecting element (60) by which the platform device (121;122) is detachably connected to the at least one drive component (44), wherein the at least one connecting element (60) extends through at least one bottom opening (35) of the chamber bottom wall (31) when the platform device is connected to the at least one drive component.

7. Laboratory shaker according to claim 6, wherein the shaking movement is parallel to the chamber bottom wall (31), wherein the bottom opening (35) is dimensioned such that the relative movement of the connecting element (60) and the chamber bottom wall (31) corresponding to the shaking movement is enabled, wherein preferably the bottom opening (35) is sealed by a sealing element (50) which is arranged between the chamber bottom wall (31) and the connecting element (60) and which is in particular connected to the connecting element (60), preferably not connected to the chamber bottom wall (31) or preferably also connected to the chamber bottom wall (31).

8. Laboratory shaker according to claim 7, wherein the connecting element (60) and / or the drive component (44) has at least one connecting means (75) by which the connecting element (60) can be detachably connected to the drive component (44), in particular while the bottom opening (35) is sealed by the sealing element (50).

9. Laboratory shaker according to claim 8, wherein the connecting means (75) includes a thread which is designed to produce a screw connection between the connecting element (60) and the transfer plate (44) and which is arranged in particular concentrically to a central longitudinal axis of the connecting element.

10. Laboratory shaker according to one of claims 6 to 9, wherein the at least one drive component, in particular a gear element, is arranged as a transmission device (44) for carrying the platform device, with which the at least one connecting element (60) can be connected.

11. Laboratory shaker according to claim 10, wherein the transmission device (44) is connected to the at least one drawer element (40) when the latter is moved between the first [inside] and the second [extended] position.

12. Laboratory shaker according to one of claims 2 to 4 and one of the other preceding claims, wherein the at least one drive component includes a pulley (41) which is coupled to the drive unit (20) via a belt (21), which is arranged in particular next to the drawer device (40; 43).

13. Laboratory shaker according to one of the preceding claims, wherein the at least one drive component includes one or more movable base parts (42) which are connected to the at least one drawer element (40) and in particular to the transfer plate (44), which support the platform device by means of the transfer plate (44).

14. Laboratory shaker according to one of the preceding claims, wherein the drawer device has a rail device (43) by means of which the at least one drawer element (40) is movably mounted in the device space on the device base (9) by means of a sliding or rolling bearing.

15. A method for actuating the drawer device, in particular for servicing the drive device of a laboratory shaker according to one of the preceding claims, comprising the steps of: • Removing the platform device from the chamber; • Optionally: Disconnecting a connecting element (75) of the at least one drive component (44) and the at least one connecting element (60), which extends to connect the platform device (121; 122) and the at least one drive component (44) through at least one bottom opening (35) of the chamber bottom wall (31), which is preferably sealed by at least one sealing element (50) during the disconnection of the connection; • Optionally: Disconnecting the at least one sealing element (50) from the connecting element (60) and / or the chamber bottom wall (31);• Moving the at least one drawer element (40) carrying the at least one drive component (44) from the first position, in which the drawer element (40) is arranged in the device space (4), to a second position, in which the drawer element (40) is extended from the device space (4); • Preferably: Maintaining the at least one drive component, in particular including at least one of the following maintenance steps: ∘ Adjusting the drive device, in particular changing the size of an orbit of the shaking motion, ∘ Replacing a drive component, in particular a drive belt; and / or ∘ Cleaning drive components; • Moving the at least one drawer element carrying the at least one drive component back from the second position to the first position.

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