Oral hygiene composition

Abstract

The present invention relates to a solid composition for the oral cavity, comprising: - (a) a blueberry fruit extract in powder form and containing anthocyanins, - (b) probiotics not containing yeast, - (c) at least one vitamin and - (d) zinc alone or as a mixture with other mineral salts. It further relates to the composition according to the invention for use in oral hygiene and / or for the prevention of dental plaque and / or for the treatment and / or prevention of conditions of the oral cavity, in particular selected from candidiasis, gingivitis, periodontitis and / or halitosis and / or mouth ulcers, and / or for promoting healing of the oral mucosa and / or for the treatment and / or prevention of oral dryness and / or for the treatment of throat pain and / or for orthodontics applications and / or for the treatment of oral alignment devices, which are in particular removable and / or fixed.

Description

Composition for oral hygiene Technical Field

[0001] The present invention relates to the field of oral hygiene and in particular to solid compositions for the oral cavity and their uses for cleaning the oral sphere. Prior art

[0002] The oral cavity is the first part of the digestive system. It contains many microorganisms that can develop abnormally, particularly in dental plaque, due in particular to a diet too rich in sugars, vitamin deficiencies, poor oral hygiene or an immune imbalance. These microorganisms can locally cause different types of oral cavity conditions such as halitosis, or bad breath, gingivitis and / or periodontitis, lesions affecting the oral mucosa and tongue, such as mouth ulcers and other oral ulcers, as well as bacterial and fungal infections (or oral mycoses) such as candidiasis, dental caries, or delay or hinder healing in the case of oral surgery.They can also, since they are swallowed, have consequences in other parts of the body such as cardiac function, or cognitive function as for example in the case of Alzheimer's disease.

[0003] In particular, dental plaque protects pathogenic bacteria and allows them to develop in such a way as to unbalance the microbiota naturally present in the mouth. These bacteria can thus give rise to cavities by causing damage to the enamel, cementum, dentin or even the pulp depending on the stage of development. Indeed, the attack on the enamel by the secretions of the bacteria forms a hole which first appears as a whitish stain then progresses to the dentin and can blacken. The cavity progresses and gradually enlarges towards the pulp which ends up being colonized by germs and necrosing. It can subsequently invade the underlying tissues, or even pass into the general circulation. The infection can develop over several months or even several years.

[0004] Periodontal diseases include damage to the supporting tissues of the teeth, namely the gums, alveolar bone, periodontal ligament, and cementum. Depending on the tissues affected, we will speak of gingivitis when the inflammation affects the gums or periodontitis when the damage affects all tissues. The bone loss resulting from these diseases is called alveolysis. Periodontal diseases are caused by the development of dental plaque, particularly in the area between the gums and the teeth. They progress to tooth loosening.

[0005] Mouth ulcers and other oral ulcers are lesions affecting the oral mucosa and / or the tongue which most often result in swelling, sores or more or less significant structural changes of the mouth, tongue and lips and can be painful, unpleasant and troublesome for chewing, swallowing or speaking.

[0006] Typically, canker sores appear primarily on the gums, tongue, and the inner edges of the lips and cheeks, and often appear as rounded or oval swellings covered by a whitish or yellowish membrane that may be surrounded by a reddish border. Canker sores can result from poor oral hygiene, allergies, poor maintenance of dentures, hormonal influences (menstrual periods or pregnancy), vitamin deficiencies, the ingestion of certain foods such as nuts or Gruyère cheese, certain medications, stress, or diseases that cause canker sores, such as Bechet's disease, which are often viral in origin.

[0007] Among fungal infections, candidiasis is an oral mycosis caused by the presence of a yeast called Candida albicans \ more commonly. There are other types of Candida such as Candida krusei. Candidiasis most often manifests itself by the presence of plaques, which may initially be creamy, whitish yellow or red in color, located on the tongue and the oral mucosa. Over time, these plaques can turn black. Candidiasis is common in people with a braces, newborns and people with weakened immune systems.

[0008] Furthermore, the oral cavity can also be the site of conditions mainly linked to bad breath (halitosis), gum and / or dental sensitivity or be the site of proliferation of numerous bacteria.

[0009] The sensation of "dry mouth" is due to an abnormal decrease in the quantity of saliva (hyposialia), or even its complete absence (asialia). Normally, the salivary glands produce about half a liter of saliva each day.

[0010] When this production decreases or falls, various symptoms can appear (increased thirst, difficulty swallowing, chewing, or even speaking, oral problems, etc.), generating a certain discomfort. This disorder, also called "xerostomia," results from various causes, starting with a one-off episode of dehydration or excessive mouth breathing in a dry environment (when this only occurs at night).

[0011] It can also be age-related and exacerbated by anxiety and depression. Chronic stress can explain dry mouth, as can certain prescription medications: Antidepressants, antihistamines, anti-inflammatories, antihypertensives, anti-Parkinson's drugs... are among the many medications that can trigger this symptom. Furthermore, chemotherapy and radiotherapy treatments, during head and neck cancer treatment (especially radiotherapy which damages the salivary glands), count xerostomia among their side effects.

[0012] Other possible causes include chronic or autoimmune diseases, such as (uncontrolled) diabetes, HIV / AIDS infection, lupus, kidney disease, and Sjogren's syndrome, a nervous system dysfunction after a stroke or trauma.

[0013] Tobacco, as well as recreational drug use (especially methamphetamines), also cause decreased salivation.

[0014] Xerostomia is also a common complaint among the elderly: 20% of them suffer from it. The sensation of thirst and saliva production decrease with age. But above all, older people take many medications and are therefore more likely to encounter this problem frequently.

[0015] The consequences are an alteration of oral hygiene due to the reduction of oral pH and the increase in bacterial growth which finds a breeding ground.

[0016] Prevention of all these oral disorders generally involves good oral hygiene, often using mechanical and systematic tooth brushing, ideally after any intake of food, drinks or other substances such as tobacco or medications likely to disrupt oral physiological conditions. However, in many contexts, this ideal is not achievable. Indeed, tooth brushing generally requires a water source and accessories such as a toothbrush and toothpaste.

[0017] There are already many formulations for oral hygiene. However, these formulations can temporarily eliminate, at the time of application, the pathogenic microorganisms responsible for oral disorders, but they do not prevent them from redeveloping, thus causing the same pathologies. Statement of the invention

[0018] The inventor surprisingly realized that the combination of blueberry fruit extract in powder form and containing anthocyanins, specifically chosen probiotics, vitamin C and zinc in a solid composition made it possible to clean the oral cavity in order to eliminate the pathogenic flora responsible for oral problems but also, simultaneously and specifically, to reseed the microbiota with beneficial probiotics thus making it possible to fight against the reappearance of the pathogenic flora.

[0019] The present invention therefore relates to a solid composition for the oral cavity comprising: - (a) a blueberry fruit extract in powder form and containing anthocyanins, - (b) probiotics not containing yeast - (c) at least one vitamin, advantageously vitamin C alone or in a mixture with other vitamins and - (d) zinc alone or in mixture with other mineral salts.

[0020] In the context of the present invention the terms "between ... and ..." and "in the range of ... to ..." mean that the limits of the range are included.

[0021] For the purposes of the present invention, the term "composition for the oral cavity" means any composition intended to act locally in the oral cavity. Thus, advantageously this composition is not intended to be swallowed immediately but must remain in the mouth long enough to release the blueberry extract and the probiotics in the mouth. It is therefore advantageously not a capsule.

[0022] The composition according to the invention therefore allows the local application, by topical route on the mucous membranes of the oral cavity and / or the teeth, of each of the ingredients (a), (b), (c) and (d), in particular simultaneously.

[0023] Advantageously, the composition according to the invention is not mucoadhesive.

[0024] In particular, the composition is not a multi-layer composition and therefore advantageously is homogeneous, that is to say that the compounds (a), (b), (c) and (e) are distributed homogeneously within the composition.

[0025] Advantageously, the composition according to the invention is in the form of a lozenge, a chewing paste or chewing gum or a gnawing composition such as a dog gnawing bone, in particular a lozenge or a chewing paste, more particularly a lozenge.

[0026] Advantageously, the lozenge dissolves very slowly in the mouth (3 to 5 minutes) to ensure optimized application time.

[0027] The composition according to the invention is intended for animals, including humans, in particular to mammals, more particularly to humans and animals for example domestic carnivores such as dogs or cats or even equines, even more particularly to humans.

[0028] The composition according to the invention therefore comprises (a) a blueberry fruit extract in powder form and containing anthocyanins, in particular at least 20% by weight of anthocyanins, more particularly at least 25% by weight of anthocyanins. Advantageously, it is an extract of wild blueberry fruits (Vaccinium myrtillus'), more advantageously obtained by extraction using a polar solvent, in particular an alcohol, more particularly ethanol, even more particularly an aqueous ethanol solution.

[0029] Advantageously, the blueberry fruit extract in powder form is obtained by atomization, more advantageously in the presence of maltodextrin.

[0030] Thus, in an advantageous embodiment, the composition according to the invention further comprises (e) maltodextrin, in particular in powder form. Advantageously, the proportion of blueberry fruit extract and maltodextrin in the blueberry fruit extract / maltodextrin mixture is in the range 55-80% blueberry fruit extract / 20-45% maltodextrin. Advantageously, the blueberry fruit extract / maltodextrin mixture in powder form according to the invention is commercially available from the company FERLUX under the trade name ANTHOCYAN 25%. Blueberry anthocyanins protect oral macrophages. Anthocyanins also block the molecular pathway involved in inflammation, a factor with a high incidence in gum disease.

[0031] Blueberry fruit extract powder therefore has both a chemical and mechanical action (by passing the grains over the oral surface) on dental plaque, which is generally responsible for oral diseases. It will therefore help create an environment favorable to the re-seeding of the beneficial flora present in probiotics (b).

[0032] In an advantageous embodiment, the content of blueberry fruit extract powder (a) of the composition according to the invention is between 0.0275% and 4% by weight relative to the total weight of the composition, advantageously between 0.055% and 0.4% by weight relative to the total weight of the composition, even more advantageously between 0.077% and 0.36% by weight relative to the total weight of the composition.

[0033] The composition according to the invention further comprises (b) probiotics not containing yeast.

[0034] Probiotics allow the oral cavity to be re-seeded with beneficial probiotics and therefore prevent pathogenic flora from reappearing.

[0035] Advantageously, these probiotics (b) are bacteria, even more advantageously bacteria chosen from lactobacillus, streptococcus, bifidobacterium, Lactiplantibacillus, Levilactobacillus and their mixtures, in particular from lactobacillus, streptococcus, bifidobacterium and their mixtures. Advantageously these probiotics (b) are bacteria chosen from Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus thermophilus, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus, Lactobacillus reuteri, Lactobacillus salivarius, Lactobacillus case!, Lactobacillus acidobacillus, Lactobacillus helveticus candisis, Streptoccocus salivarius, Bifidobacterium Iactis, Bifidobacterium animaiis, Bifidobacterium iongum, Bifidobacterium breve, Lactiplantibacillus plantarum, Levilactobacillus brevis and their mixtures, more advantageously chosen from Lactobacillus acidophilus,Lactobacillus rhamnosus, Lactobacillus thermophilus, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus, Lactobacillus reuteri, Streptoccocus salivarius, Bifidobacterium iactis and their mixtures, even more advantageously it is Bifidobacterium iactis or a mixture of Streptoccocus salivarius and Lactobacillus reuteri, or a mixture of Lactobacillus acidophilus, Lactobacillus rhamnosus and Lactobacillus thermophilus or a mixture of Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus and Lactobacillus reuteri or a mixture of Lactobacillus salivarius, Lactobacillus reuteri, Lactobacillus case!, Bifidobacterium animaiis, Lactiplantibacillus plantarum, and Levilactobacillus brevis or a mixture of Lactobacillus reuteri, Lactobacillus rhamnosus and Lactobacillus acidophilus or a mixture of Lactobacillus gasse, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus, Lactobacillus reuteri, Bifidobacterium lactis and Bifidobacterium iongum or a mixture of Lactobacillus acidobaciiius, Lactobacillus fermentum, Lactobacillus rhamnosus, Lactobacillus thermophilus, Lactobacillus helveticus candisis and Bifidobacterium breve.

[0036] Even more advantageously, the probiotics (b) according to the invention are tyndalized. Tyndallization is a sterilization process which consists of a series of discontinuous heatings at a relatively low temperature (60°C), separated by periods of rest at room temperature. This process is used to eliminate the resistant forms of bacteria, namely spores, from the medium while preserving the integrity of the membranes.

[0037] The interest of Tyndallized strains also called postbiotics or parabiotics is to preserve their beneficial properties for the host and interact mainly at 3 levels: - at the microbial level, by inhibiting the adhesion of pathogens, their invasion and therefore preventing the formation of bacterial biofilms. - at the host level, by adhering to the mucous membranes and thus forming a protective barrier. An anti-inflammatory immunomodulatory action is then ensured by the components of the cell wall and the probiotic metabolites. This anti-inflammatory action reinforces that of the anthocyanins. - at the manufacturing process level, by allowing the use of higher pressure. Indeed, the pressure exerted to produce the lozenge is very high: around 200 bars (20 MPa). Such pressure is much more fatal for non-tyndallized strains.

[0038] In an advantageous embodiment, the probiotic content (b) of the composition according to the invention is between 1 and 10%, advantageously between 1 and 7%, more advantageously between 1 and 3% by weight relative to the total weight of the composition.

[0039] The composition according to the invention further comprises (c) at least one vitamin. Advantageously, (c) the vitamin is vitamin C, alone or in a mixture with other vitamins, in particular chosen from vitamins A, E, D, in particular D3, K2, B2, B3, B6, B9, B8 and B12, such as a mixture of vitamins A, D, K2, B2, B3, B6, B9, B8 and B12 or a mixture of vitamins A, E and B8, advantageously in a content representing between 20 and 40% of the RDA, in particular 30% of the RDA.

[0040] Thus advantageously, the composition according to the invention comprises (c) vitamin C, advantageously in powder form, in particular in a content representing between 10% and 20% of the Recommended Daily Intake (RDI), more particularly 15% of the RDI.

[0041] In the context of the present invention, vitamin C helps, in addition to strengthening the immune system, to activate wound healing. It is also involved in the synthesis of collagen which strengthens connective tissue (including the gums), ligaments and bones.

[0042] The composition according to the present invention also comprises (d) zinc, alone or in a mixture with other mineral salts, such as for example magnesium and / or calcium.

[0043] Advantageously, zinc is found in the form of zinc bisglycinate. Advantageously, the zinc content of the composition according to the invention represents between 10% and 20% of the RDA, more particularly between 14% and 15% of the RDA. Zinc plays an essential role in healing. It plays a key role in enzymatic reactions, particularly in the metabolism of lipids, carbohydrates and proteins. It ensures better wound healing, both in topical and general application, and strengthens the immune system.

[0044] The composition according to the present invention may also comprise magnesium, in particular in the form of magnesium bisglycinate. More particularly, the magnesium content of the composition according to the invention represents between 10 and 20% of the RDA, advantageously 15% of the RDA.

[0045] The composition according to the present invention may further comprise one or more ingredients chosen from sweeteners, bulking agents, sequestrants, humectants, omega 3, propolis, flavorings, acidifiers, trace elements, anti-caking agents, sorbitol, xylitol, Aloe Ferox, camu camu, amla, black garlic and mixtures thereof, advantageously chosen from sweeteners, bulking agents, sequestrants, humectants, omega 3, propolis, flavorings, acidifiers, trace elements, anti-caking agents, sorbitol and mixtures thereof, more advantageously chosen from maltodextrin, selenium, omega 3, sorbitol, steviol glycosides, propolis, cassava starch, citric acid, flavorings, xylitol, Aloe Ferox, camu camu, amla, black garlic, caprylic acid and their mixtures, even more advantageously chosen from selenium, omega 3, sorbitol, steviol glycosides, propolis, cassava starch, citric acid, flavorings and their mixtures.

[0046] Advantageously, the composition according to the invention does not contain green tea extract and / or fish oil and / or other extracts and / or powder of fruits and / or vegetables, apart from blueberry fruit extract (a) and sea buckthorn oil and / or, apart from blueberry fruit extract (a), sea buckthorn oil, Aloe Ferox, camu camu, amla and black garlic.

[0047] Even more advantageously, the composition according to the invention does not comprise prebiotics (such as inulin, fructooligosaccharide, galactooligosaccharides, soy oligosaccharide and / or lactulose) and / or lactose and / or glucose and / or gluconolactone and / or boswellia extract and / or A'rtemisia annua extract and / or Magnolia officinalis extract and / or carrageens and / or sodium erythorbate and / or ginger.

[0048] Advantageously, the composition according to the present invention comprises (f) anti-caking agents such as tricalcium phosphate, more particularly in a content of between 5% and 15% by weight relative to the total weight of the composition, advantageously between 10 and 13%, more advantageously between 10 and 11% by weight, relative to the total weight of the composition.

[0049] The composition according to the present invention may also comprise (g) omega 3, in particular in the form of sea buckthorn oil. Advantageously, the omega 3 is not found in the form of fish oil. More advantageously the sea buckthorn oil content of the composition according to the invention is between 1% and 5%, in particular between 1% and 2% by weight relative to the total weight of the composition, more advantageously between 1.3% and 1.4% by weight relative to the total weight of the composition.

[0050] Advantageously, the composition according to the present invention comprises (h) sorbitol, advantageously in a content of between 4% and 85%, more advantageously between 60% and 85%, even more advantageously between 70% and 85% by weight relative to the total weight of the composition, in particular in a content of between 76% and 82% by weight relative to the total weight of the composition. This active ingredient acts as a sequestrant, excipient, humectant or stabilizer. Its presence improves oral hygiene by preventing pathogenic bacteria from proliferating. Indeed, the latter cannot metabolize it.

[0051] Advantageously, sorbitol can be replaced by xylitol, in the same proportions.

[0052] Advantageously, the composition according to the invention further comprises (i) a bulking agent such as cassava starch, in particular in a content of between 2% and 15%, advantageously between 2% and 3% by weight relative to the total weight of the composition, more particularly in a content of between 2.1% and 2.2% by weight relative to the total weight of the composition.

[0053] The composition according to the present invention may also comprise (j) citric acid, in particular in a content of between 0.05% and 0.5% by weight relative to the total weight of the composition, in particular in a content of between 0.2% and 0.3% by weight relative to the total weight of the composition. Citric acid is a flavor enhancer.

[0054] Advantageously, the composition according to the present invention comprises (k) a sweetener such as steviol or stevia glycosides, advantageously in a content of between 0.005% and 0.05% by weight relative to the total weight of the composition, in particular in a content of between 0.01% and 0.02% by weight relative to the total weight of the composition.

[0055] Advantageously, the composition according to the invention further comprises (I) a flavoring, in particular lemon, advantageously in a content of between 2% and 3% by weight relative to the total weight of the composition, more particularly in a content of between 2.1% and 2.2% by weight relative to the total weight of the composition.

[0056] Thus, in one embodiment of the invention, the composition comprises, in particular is constituted by: - (a) a blueberry fruit extract in powder form and containing anthocyanins, - (b) probiotics not containing yeast, - (c) at least one vitamin, advantageously vitamin C alone or in a mixture with other vitamins, - (d) zinc alone or in mixture with other mineral salts, in particular in the form of zinc bisglycinate - (e) maltodextrin, - (f) an anti-caking agent, advantageously tricalcium phosphate, - (g) omega 3, particularly in the form of sea buckthorn oil, - (h) sorbitol, - (i) a bulking agent such as cassava starch, - (j) citric acid, - (k) a sweetener such as steviol glycosides and - (I) an aroma.

[0057] The composition according to the present invention may further comprise (m) one or more trace elements, such as selenium, in particular in the form of selenium yeast, more particularly in a content representing between 20 and 40% of the RJ, advantageously 30% of the RJ.

[0058] Thus, in one embodiment of the invention, the composition comprises, in particular is constituted by: - (a) a blueberry fruit extract in powder form and containing anthocyanins, - (b) probiotics not containing yeast, - (c) a mixture of vitamin C with other vitamins, in particular chosen from vitamins A, E, D, K2, B2, B3, B6, B9, B8 and B12, such as a mixture of vitamins A, C, D, K2, B2, B3, B6, B9, B8 and B12 or a mixture of vitamins A, C, E and B8, - (d) a mixture of zinc with other mineral salts, advantageously a mixture of zinc and magnesium, in particular in the form of a mixture of zinc bisglycinate and magnesium bisglycinate, - (e) maltodextrin, - (f) an anti-caking agent, advantageously tricalcium phosphate, - (g) omega 3, particularly in the form of sea buckthorn oil, - (h) sorbitol, - (i) a bulking agent such as cassava starch, - (j) citric acid, - (k) a sweetener such as steviol glycosides, - (I) an aroma and - (m) one or more trace elements, such as selenium, particularly in the form of selenium yeast.

[0059] The composition according to the present invention may also comprise (n) propolis, advantageously in powder form, in particular in a content of between 1 and 5% by weight relative to the total weight of the composition, more particularly in a content of between 2% and 3% by weight relative to the total weight of the composition. Propolis has in particular an anti-infectious and healing action.

[0060] Thus, in one embodiment of the invention, the composition comprises, in particular is constituted by: - (a) a blueberry fruit extract in powder form and containing anthocyanins, - (b) probiotics not containing yeast, - (c) a mixture of vitamin C with other vitamins, in particular chosen from vitamins A, E, D, K2, B2, B3, B6, B9, B8 and B12, such as a mixture of vitamins A, C, D, K2, B2, B3, B6, B9, B8 and B12 or a mixture of vitamins A, C, E and B8, - (d) a mixture of zinc with other mineral salts, advantageously a mixture of zinc and magnesium, in particular in the form of a mixture of zinc bisglycinate and magnesium bisglycinate, - (e) maltodextrin, - (f) an anti-caking agent, advantageously tricalcium phosphate, - (g) omega 3, particularly in the form of sea buckthorn oil, - (h) sorbitol, - (i) a bulking agent such as cassava starch, - (j) citric acid, - (k) a sweetener such as steviol glycosides, - (I) an aroma and - (n) propolis.

[0061] The composition according to the present invention may also comprise (o) aloe ferox, advantageously in powder form, in particular in a content of between 1 and 10% by weight relative to the total weight of the composition, more particularly in a content of between 5% and 9% by weight relative to the total weight of the composition. Aloe ferox has in particular a softening, moisturizing and healing action

[0062] Thus, in one embodiment of the invention, the composition comprises, in particular is constituted by: - (c) at least one vitamin, advantageously vitamin C alone or in a mixture with other vitamins, in particular only vitamin C, - (d) zinc alone or in mixture with other mineral salts, in particular in the form of zinc bisglycinate, - (e) maltodextrin, - (f) an anti-caking agent, advantageously tricalcium phosphate, - (g) omega 3, particularly in the form of sea buckthorn oil, - (h) sorbitol, - (i) a bulking agent such as cassava starch, - (j) citric acid, - (k) a sweetener such as steviol glycosides - (I) an aroma and - (o) aloe ferox.

[0063] The composition according to the present invention may also comprise (p) a plant chosen from Camu Camu, amla, black garlic and their mixtures, advantageously in powder form, in particular in a content of between 1 and 50% by weight relative to the total weight of the composition, more particularly in a content of between 3% and 45% by weight relative to the total weight of the composition. These plants / fruits have in particular a healing, toning, anti-inflammatory and anti-fungal proliferation action. Camu camu is the Amazonian cherry on the Bolivian side. This fruit is a concentrate of vitamin C, antioxidants and vitamin B1, B2, B3. Amla or Ceylon gooseberry has fruits very rich in vitamin C which are very good tissue regenerators.

[0064] The composition according to the present invention may also comprise (q) caprylic acid, in particular in a content of between 5 and 15% by weight relative to the total weight of the composition, more particularly in a content of between 8% and 12% by weight relative to the total weight of the composition. Caprylic acid has in particular an antifungal and antibacterial action.

[0065] Thus, in one embodiment of the invention, the composition comprises, in particular is constituted by: - (c) at least one vitamin, advantageously vitamin C alone or in a mixture with other vitamins, in particular a mixture of vitamin C and vitamin D, more particularly a mixture of vitamin C and vitamin D 3, - (d) zinc alone or in mixture with other mineral salts, in particular in the form of zinc bisglycinate, - (e) maltodextrin, - (f) an anti-caking agent, advantageously tricalcium phosphate, - (g) omega 3, particularly in the form of sea buckthorn oil, - (h) sorbitol, - (i) a bulking agent such as cassava starch, - (j) citric acid, - (k) a sweetener such as steviol glycosides - (I) an aroma - (p) a plant chosen from Camu Camu, amla, black garlic and their mixtures, more particularly a mixture of these plants, and - (q) caprylic acid.

[0066] Thus the compositions according to the invention can be the following:

[0067] A lozenge or chewing gum, advantageously intended for the treatment and / or prevention of halitosis, the composition of which comprises, in particular consists of: - (al)a blueberry fruit extract in powder form and containing anthocyanins, - (bl) a mixture of Streptoccocus sa / ivarius and Lactobacillus reuteri, in particular tyndalized - (cl) vitamin C, - (dl) zinc, especially in the form of zinc bisglycinate - (el) maltodextrin, - (fl) tricalcium phosphate, - (gl) omega 3, particularly in the form of sea buckthorn oil, - (hl) sorbitol, - (it) cassava starch, - (jl) citric acid, - (kl) steviol glycosides and - (It) has an aroma.

[0068] A lozenge or chewing gum, advantageously intended for the treatment and / or prevention of periodontitis, the composition of which comprises, in particular is made up of: - (a2) a blueberry fruit extract in powder form and containing anthocyanins, - (b2) a mixture of Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus heiveticus and Lactobacillus reuteri, in particular tyndalized, optionally in a mixture with bifibobacteria - (c2) vitamin C, - (d2) zinc, particularly in the form of zinc bisglycinate - (e2) maltodextrin - (f2) tricalcium phosphate, - (g2) omega 3, particularly in the form of sea buckthorn oil, - (h2) sorbitol, - (i2) cassava starch, - (j2) citric acid, - (k2) steviol glycosides and - (12) an aroma.

[0069] A lozenge or chewing gum, advantageously intended for the treatment and / or prevention of candidiasis, the composition of which comprises, in particular is made up of: - (a3) ​​a blueberry fruit extract in powder form and containing anthocyanins, - (b3) a mixture of Lactobacillus acidophilus, Lactobacillus rhamnosus and Lactobacillus thermophilus, in particular tyndalized - (c3) a mixture of vitamins C, A, E and B8, - (d3) zinc and magnesium, in particular in the form of zinc bisglycinate and magnesium bisglycinate, - (e3) maltodextrin, - (f3) tricalcium phosphate, - (g3) omega 3, particularly in the form of sea buckthorn oil, - (h3) sorbitol, - (i3) cassava starch, - (j3) citric acid, - (k3) steviol glycosides, - (13) an aroma and - (m3) selenium, particularly in the form of selenium yeast.

[0070] A lozenge or chewing gum, advantageously intended to promote healing, the composition of which comprises, in particular is made up of: - (a4) a blueberry fruit extract in powder form and containing anthocyanins, - (b4) Bifidobacterium iactis, in particular tyndalized - (c4) a mixture of vitamins C, A, D, K2, B2, B3, B6, B9, B8 and B12, - (d4) zinc, particularly in the form of zinc bisglycinate - (e4) maltodextrin - (f4) tricalcium phosphate, - (g4) omega 3, particularly in the form of sea buckthorn oil, - (h4) sorbitol, - (i4) cassava starch, - (j4) citric acid, - (k4) steviol glycosides, - (14) an aroma and - (n4) propolis.

[0071] A chewing gum, advantageously intended for orthodontics, more particularly for a mouth alignment device, even more particularly removable, or a lozenge, advantageously intended for orthodontics, more particularly for a mouth alignment device, even more particularly fixed, the composition of which comprises, in particular is constituted by: - (a5) a blueberry fruit extract in powder form and containing anthocyanins, - (b5) a mixture of Lactobacillus saiivarius, Lactobacillus reuteri, Lactobacillus casei, Bifidobacterium animaiis, Lactipiantibaciiius piantarum and Levilactobacillus brevis, in particular tyndalized - (c5) vitamin C, - (d5) zinc, particularly in the form of zinc bisglycinate - (e5) maltodextrin, - (f5) tricalcium phosphate, - (g5) omega 3, particularly in the form of sea buckthorn oil, - (h5) sorbitol, - (i5) cassava starch, - (j5) citric acid, - (k5) steviol glycosides and - (15) an aroma.

[0072] A lozenge or chewable paste, advantageously intended for the treatment or prevention of dry mouth, the composition of which comprises, in particular consists of: - (a6) a blueberry fruit extract in powder form and containing anthocyanins, - (b6) a mixture of Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus acidophilus, in particular tyndalized - (c6) vitamin C, - (d6) zinc, particularly in the form of zinc bisglycinate - (e6) maltodextrin, - (f6) tricalcium phosphate, - (g6) omega 3, particularly in the form of sea buckthorn oil, - (h6) xylitol, - (i6) cassava starch, - (j6) citric acid, - (k6) steviol glycosides and - (16) an aroma.

[0073] A lozenge or chewing gum, advantageously intended for the treatment and / or prevention of periodontitis, more particularly aggressive forms of periodontitis, the composition of which comprises, in particular is made up of: - (a7) a blueberry fruit extract in powder form and containing anthocyanins, - (b7) a mixture of Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus, Lactobacillus reuteri, Bifidobacterium iactises Bifidobacterium iongum, in particular tyndalized, - (c7) vitamin C, - (d7) zinc, particularly in the form of zinc bisglycinate - (e7) maltodextrin - (f7) tricalcium phosphate, - (g7) omega 3, particularly in the form of sea buckthorn oil, - (h7) sorbitol, - (i7) cassava starch, - (j7) citric acid, - (k7) steviol glycosides - (17) an aroma and - (o7) Aloe Ferox.

[0074] A lozenge or chewing gum, advantageously intended for the treatment and / or prevention of candidiasis, in particular aggressive forms of candidiasis, the composition of which comprises, in particular is constituted by: - (a8) a blueberry fruit extract in powder form and containing anthocyanins, - (b8) a mixture of Lactobacillus acidobaciiius, Lactobacillus fermentum, Lactobacillus rhamnosus, Lactobacillus thermophiius, Lactobacillus heiveticus candisis and Bifidobacterium breve, in particular tyndalized - (c8) a mixture of vitamins C and D3, - (d8) zinc, in particular in the form of zinc bisglycinate, - (e8) maltodextrin, - (f8) tricalcium phosphate, - (g8) omega 3, particularly in the form of sea buckthorn oil, - (h8) sorbitol, - (i8) cassava starch, - (j8) citric acid, - (k8) steviol glycosides, - (18) an aroma - (p8) a mixture of camu camu, amla and black garlic and - (q8) caprylic acid.

[0075] The present invention further relates to a process for preparing these compositions comprising the steps of mixing the ingredients and shaping the composition, in particular by compression to manufacture tablets. Advantageously, the mixing of the ingredients is in powder form. Advantageously, the process according to the invention comprises a resting step between mixing and shaping in order to achieve the most perfect impregnation and homogenization possible.

[0076] Advantageously, the shaping pressure is high (in particular greater than or equal to 10 MPa, more advantageously greater than or equal to 20 MPa) in order to obtain a high density so that the tablet dissolves very slowly in the mouth (3 to 5 minutes) and therefore ensures an optimized application time.

[0077] To make chewing gum or chewing paste, a mixture of artificial or natural (vegetable) gums can be added to which waxes or plasticizers, flavors and sweeteners are added to obtain the desired consistency, texture and finish. The active ingredients are added. This mixture is then kneaded and then heated to a higher or lower temperature depending on the machines used. In the case of the present invention, excessive heating will be avoided so as not to degrade the probiotics. After this step, the mixture becomes plastic and is poured or injected into molds and left to cool. The pastes / gums are then packaged.

[0078] The present invention further relates to the composition according to the invention, for its use as a medicament, advantageously for the prevention of dental plaque and / or for the treatment and / or prevention of affections of the oral cavity, in particular chosen from candidiasis, gingivitis and / or periodontitis and / or mouth ulcers, in particular aggressive and / or severe forms of candidiasis and / or periodontitis, and / or to promote the healing of the oral mucosa and / or for the treatment and / or prevention of dry mouth and / or for the treatment of sore throats and / or for applications in orthodontics.

[0079] The present invention further relates to the non-therapeutic use of the composition according to the invention for oral hygiene and / or for the treatment and / or prevention of halitosis and / or for the treatment of oral alignment devices, in particular removable and / or fixed.

[0080] In particular, the composition according to the invention is administered orally outside of meals and more particularly away from these meals or after said meals. The dose and duration of administration depend on the intended use and can range from 1 to 3 doses per day for a period of 20 days to one month, or even 3 months, 6 months or more. Advantageously, the tablets have a weight of between 2 and 3g, advantageously 2.3g. Advantageously, the chewing gum / chewing paste has a weight of between 2 and 4g. In particular: - in the case of treatment of candidiasis, the recommended dose is 2 to 3 lozenges / chewing gums / chewing pastes per day for 3 to 6 months; - in the case of periodontitis treatment, the recommended dose is 1 lozenge / chewing gum / chewing paste per day for at least 3 weeks, generally 3 weeks to 3 months but it can go up to more than 6 months; - in the case of halitosis treatment, the recommended dose is 1 to 3 lozenge(s) / chewing gum(s) / chewing paste(s) per day every day; - to promote healing, the recommended dose is 3 lozenges / chewing gums / pastes per day after each meal for 10 days.

[0081] The present invention further relates to a method for oral hygiene and / or for the prevention of dental plaque and / or for the treatment and / or prevention of disorders of the oral cavity, in particular selected from candidiasis, gingivitis, periodontitis and / or halitosis and / or mouth ulcers, in particular aggressive and / or severe forms of candidiasis and / or periodontitis, and / or for promoting healing of the oral mucosa, and / or for the treatment and / or prevention of dry mouth and / or for the treatment of sore throats and / or for applications in orthodontics, in particular and / or for the treatment of oral alignment devices, in particular removable and / or fixed, comprising administering the composition according to the invention orally to a patient in need thereof, in particular in an effective amount, in particular as described above.

[0082] It finally relates to the use of a composition according to the invention for the preparation of a medicament, advantageously intended for the prevention of dental plaque and / or for the treatment and / or prevention of affections of the oral cavity, in particular chosen from candidiasis, gingivitis and / or periodontitis and / or mouth ulcers, and / or to promote the healing of the oral mucosa, and / or for the treatment and / or prevention of dry mouth and / or for the treatment of sore throats and / or for applications in orthodontics.

[0083] The present invention will be better understood upon reading the description of the following examples which are given for non-limiting information purposes. EXAMPLES Example 1: Anti-halitosis lozenge

[0084] The tablet has the following composition:

[0085] [Table 1]

[0086] The different constituents, mainly in powder form, are first mixed to create a blend. This blend is left to rest in order to achieve the most perfect impregnation and homogenization possible.

[0087] In a second step, this blend is placed in a distribution hopper in the shaping machine (press) then injected and shaped by pressure.

[0088] The shaping pressure is high in order to obtain a high density so that the tablet dissolves very slowly in the mouth (3 to 5 minutes) and therefore ensures an optimized application time.

[0089] The advantage of the lozenge according to the invention is that it cleans and reseeds at the same time, unlike current usual products which mask the odor by adding a strong one but without treating the origin of the problem which is the dysbiosis of the dorsolingual flora.

[0090] Example 2: Anti-periodontitis lozenge

[0091] The tablet has the following composition:

[0092] [Table 2]

[0093] The tablet is prepared in the same way as that of Example 1. Example 3: Anti-candidiasis lozenge

[0094] The tablet has the following composition:

[0095] [Table 3]

[0096] The tablet is prepared in the same way as that of Example 1. Example 4: lozenge for healing

[0097] The tablet has the following composition:

[0098] [Table 4]

[0099] The tablet is prepared in the same way as that of Example 1. Example 5: in vivo tests on periodontitis

[0100] 10 patients (men and women) aged 26 to 66 years and suffering from periodontitis at various stages were treated for between 20 days and 6 1 / 2 months using the anti-periodontitis tablets of example 2 with the dosage: 1 tablet per day outside of meals. The presence of bacteria and their quantities (strongly increased concentration +++, increased concentration ++, weakly increased concentration +, concentration below the detection limit -) were determined using BACTOdent before and after treatment.

[0101] All patients saw a decrease in the amount of pathogenic bacteria present in the mouth and therefore an improvement in their periodontitis.

[0102] In particular, the tablet is most effective against the bacteria Porphyromonas gingiva / is and Eikenella corrodens. It is also very effective against the bacteria Campylobacter rectus, Prevotella intermedia, Parvimonas micra. It is also effective against the bacteria Tannereiia forsythia, Treponema denticoia, Capnocytophaga gingivaiis. It is slightly less effective against the bacteria Fusobacterium nucieatum.

[0103] The use of the tablet according to the invention therefore has a strong impact on periodontitis, allowing its treatment but also its prevention. Example 6: In vivo tests on candidiasis

[0104] A patient with oral candidiasis of the tongue and palate was treated for 6 months using the anti-candidiasis tablets of Example 3 with the dosage: 3 tablets per day between meals.

[0105] The candidiasis disappeared after treatment. Example 7: Anti-halitosis chewing gum

[0106] The chewing gum has the same composition as that of example 1, the only difference being in its preparation process which is as follows: the active ingredients, the excipients and the gums are kneaded, more or less heated then poured or injected.

[0107] The result is the same as with tablets. However, chewing gum formulation is more convenient than lozenges because it is easier and more discreet to carry a pack of gum than a tube of tablets. Example 8: Healing chewing gum

[0108] The chewing gum has the same composition as that of Example 4, the only difference being in its preparation process which is identical to that of Example 7.

[0109] In addition, chewing gum can also be useful for treating canker sores, wounds, and sore throats.

[0110] The practical aspect in the form of a chewing gum pack allows for simple, discreet and on-demand use. Example 9: Chewing gum for oral aligner

[0111] The principle is to ensure the patient has the correct positioning of his or her aligner(s) by moving a gum and also to seed his or her flora to have well-aligned teeth while having healthy gums, which is not currently the case where the orthodontist is content to move the teeth without worrying about the gums.

[0112] The chewing gum has the following composition:

[0113] [Table 5]

[0114] The probiotics are a mixture of Lactobacillus saiivarius, Lactobacillus reuteri, Lactobacillus case!, Bifidobacterium animalis, Lactiplantibacillus plantarum and Levilactobacillus brevis.

[0115] The manufacturing process is the same as that of Example 7. Example 10: Orthodontic lozenge

[0116] While orthodontic treatments have evolved towards "removable aligners" also called "splints" in 80% of cases, there are still around 20% of conventional treatments called fixed. In these cases, the use of chewable pastes is not recommended because these pastes risk detaching the devices fixed to the teeth.

[0117] Choosing a slow-dissolving tablet to clean and reseed tooth surfaces is therefore a good idea.

[0118] The composition of the lozenge is therefore the same as that of example 9. The manufacturing process is the same as that of example 1. Example 11: Tablet and chewable paste for dry mouth

[0119] The composition of the lozenge and chewable paste is the same as in Example 9 except that sorbitol is replaced by xylitol and the probiotics are replaced by a mixture of Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus acidophilus.

[0120] The manufacturing process of the lozenge is the same as that of Example 1 and the manufacturing process of the chewable paste is the same as that of Example 9.

[0121] The innovative treatment we offer comes in two dosage forms: chewable paste or slow-dissolving lozenges. It cleans dental and oral surfaces, stimulates salivation, and re-seeds the tissues with protective bacteria. ite- reinforced formula

[0122] Long-standing periodontal disorders or very aggressive forms of periodontal degradation (e.g., Ulcero-Necrotic Gingivitis) show a very active pathogenic flora. The indication of local or general therapeutic treatments obviously remains essential.

[0123] To preserve and improve, if necessary, the results obtained, it is appropriate to use in addition slow-dissolving lozenges in a reinforced formulation aimed at reconstituting superficial and deep periodontal flora.

[0124] The tablet has the following composition:

[0125] [Table 6]

[0126] The tablet is prepared in the same way as that of Example 1. Example 13: Anti-candidiasis lozenge - enhanced action

[0127] Oral and often intestinal candidiasis, which has been present for a long time or is linked to pathologies that reduce the host's immune capacity, has the specific characteristic of establishing a three-dimensional biofilm on the oral and intestinal tissues. It is this three-dimensional aspect that makes treatment very difficult, long and complex.

[0128] This is why an improved version of the candidiasis lozenge has been developed to restore tissue balance as quickly as possible.

[0129] The tablet has the following composition:

[0130] [Table 7]

[0131] The tablet is prepared in the same way as that of Example 1.

Claims

Claims

1. A solid composition for the oral cavity comprising: - (a) a blueberry fruit extract in powder form and containing anthocyanins, - (b) probiotics not containing yeast - (c) at least one vitamin, advantageously vitamin C alone or in a mixture with other vitamins and - (d) zinc alone or in mixture with other mineral salts.

2. Composition according to claim 1, characterized in that the probiotics (b) are tyndalized.

3. Composition according to any one of claims 1 or 2, characterized in that the probiotics (b) are bacteria chosen from lactobacillus, streptococcus, bifidobacterium, Lactiplantibacillus, Levilactobacillus and mixtures thereof, advantageously chosen from Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus thermophilus, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus, Lactobacillus reuteri, Lactobacillus salivarius, Lactobacillus case!, Lactobacillus acidobacillus, Lactobacillus helveticus candisis, Streptoccocus salivarius, Bifidobacterium Iactis, Bifidobacterium animaiis, Bifidobacterium iongum, Bifidobacterium breve, Lactiplantibacillus plantarum, Levilactobacillus brevis and their mixtures, more advantageously it is Bifidobacterium iactis or a mixture of Streptoccocus salivarius and Lactobacillus reuteri, or a mixture of Lactobacillus acidophilus,Lactobacillus rhamnosus and Lactobacillus thermophilus or a mixture of Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus and Lactobacillus reuteri or a mixture of Lactobacillus salivarius, Lactobacillus reuteri, Lactobacillus casei, Bifidobacterium animaiis, Lactiplantibacillus plantarum and Levilactobacillus brevis or a mixture of Lactobacillus reuteri, Lactobacillus rhamnosus and Lactobacillus acidophilus or a mixture of Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus, Lactobacillus reuteri, Bifidobacterium iactis and Bifidobacterium iongum or a mixture of Lactobacillus acidobacillus, Lactobacillus fermentum, Lactobacillus rhamnosus, Lactobacillus thermophilus, Lactobacillus helveticus candisis and Bifidobacterium breve.

4. Composition according to any one of claims 1 to 3, characterized in that the content of blueberry fruit extract (a) is between 0.0275% and 4% by weight relative to the total weight of the composition, advantageously between 0.055% and 0.4% by weight relative to the total weight of the composition.

5. Composition according to any one of claims 1 to 4, characterized in that it further comprises one or more ingredients chosen from sweeteners, bulking agents, sequestrants, humectants, omega 3, propolis, flavorings, acidifiers, trace elements, anti-caking agents, sorbitol, xylitol, Aloe Ferox, camu camu, amla, black garlic and mixtures thereof, advantageously chosen from maltodextrin, selenium, omega 3, sorbitol, steviol glycosides, propolis, cassava starch, citric acid, flavorings, xylitol, Aloe Ferox, camu camu, amla, black garlic, caprylic acid and mixtures thereof.

6. Composition according to any one of claims 1 to 5, characterized in that it does not contain other fruit and / or vegetable extracts, apart from blueberry fruit extract (a), sea buckthorn oil, Aloe Ferox, camu camu, amla and black garlic.

7. Composition according to any one of claims 1 to 6, characterized in that it is a lozenge, a chewing paste or chewing gum, or a gnawing composition, in particular a lozenge or chewing gum.

8. Lozenges or chewing gum according to claim 7, characterized in that its composition comprises, in particular is constituted by: - (al)a blueberry fruit extract in powder form and containing anthocyanins, - (bl) a mixture of Streptoccocus saiivarius and Lactobacillus reuteri, - (cl) vitamin C, - (dl) zinc, especially in the form of zinc bisglycinate - (el) maltodextrin, - (fl) tricalcium phosphate, - (gl) omega 3, particularly in the form of sea buckthorn oil, - (hl) sorbitol, - (it) cassava starch, - (jl) citric acid, - (kl) steviol glycosides and - (It) has an aroma.

9. Lozenges or chewing gum according to claim 7, characterized in that its composition comprises, in particular is constituted by: - (a2) a blueberry fruit extract in powder form and containing anthocyanins, - (b2) a mixture of Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus heiveticus and Lactobacillus reuteri, or (b5) a mixture of Lactobacillus saiivarius, Lactobacillus reuteri, Lactobacillus case!, Bifidobacterium animalis, Lactiplantibacillus plantarum and Levilactobacillus brevis or (b6) a mixture of Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus acidophilus, e - (c2) vitamin C, - (d2) zinc, particularly in the form of zinc bisglycinate - (e2) maltodextrin, - (f2) tricalcium phosphate, - (g2) omega 3, particularly in the form of sea buckthorn oil, - (h2) sorbitol or (h6) xylitol, - (i2) cassava starch, - (j2) citric acid, - (k2) steviol glycosides and - (12) an aroma.

10. Lozenges or chewing gum according to the claim 7, characterized in that its composition comprises, in particular is constituted by: - (a3) ​​a blueberry fruit extract in powder form and containing anthocyanins, - (b3) a mixture of Lactobacillus acidophilus, Lactobacillus rhamnosus and Lactobacillus thermophilus, - (c3) a mixture of vitamins C, A, E and B8, - (d3) zinc and magnesium, in particular in the form of zinc bisglycinate and magnesium bisglycinate, - (e3) maltodextrin, - (f3) calcium, especially in the form of tricalcium phosphate, - (g3) omega 3, particularly in the form of sea buckthorn oil, - (h3) sorbitol, - (i3) cassava starch, - (j3) citric acid, - (k3) steviol glycosides, - (13) an aroma and - (m3) selenium, particularly in the form of selenium yeast.

11. Lozenges or chewing gum according to claim 7, characterized in that its composition comprises, in particular is constituted by: - (a4) a blueberry fruit extract in powder form and containing anthocyanins, - (b4) Bifidobacterium iactis, - (c4) a mixture of vitamins C, A, D, K2, B2, B3, B6, B9, B8 and B12, - (d4) zinc, particularly in the form of zinc bisglycinate - (e4) maltodextrin - (f4) tricalcium phosphate, - (g4) omega 3, particularly in the form of sea buckthorn oil, - (h4) sorbitol, - (i4) cassava starch, - (j4) citric acid, - (k4) steviol glycosides and - (14) an aroma, - (n4) propolis.

12. A lozenge or chewing gum according to claim 7, characterized in that its composition comprises, in particular consists of: - (a7) a blueberry fruit extract in powder form and containing anthocyanins, - (b7) a mixture of Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus brevis, Lactobacillus helveticus, Lactobacillus reuteri, Bifidobacterium iactis and Bifidobacterium iongum, in particular tyndalized, - (c7) vitamin C, - (d7) zinc, particularly in the form of zinc bisglycinate - (e7) maltodextrin - (f7) tricalcium phosphate, - (g7) omega 3, particularly in the form of sea buckthorn oil, - (h7) sorbitol, - (i7) cassava starch, - (j7) citric acid, - (k7) steviol glycosides - (17) an aroma and - (o7) Aloe Ferox.

13. Non-therapeutic use of the composition according to any one of claims 1 to 12, for oral hygiene and / or for the treatment and / or prevention of halitosis and / or for the treatment of oral alignment devices, in particular removable and / or fixed.

14. Composition according to any one of claims 1 to 12, for use as a medicament.

15. Composition according to any one of claims 1 to 12, for its use for the prevention of dental plaque and / or for the treatment and / or prevention of disorders of the oral cavity, in particular chosen from candidiasis, gingivitis and / or periodontitis and / or mouth ulcers, and / or to promote healing of the oral mucosa and / or for the treatment and / or prevention of dry mouth and / or for the treatment of sore throats and / or for applications in orthodontics.

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