Closure cap for the sterilization or filling of a medical article

Abstract

The invention relates to a closure cap for the sterilization or aseptic filling of medical articles, in particular for the sterilization of dialysers and treatment kits for dialysis, wherein a closure plug is mounted on the main body of the closure cap via a releasable or movable connection (132), and the closure plug can be moved from an open position, allowing a sterilizing fluid to pass through, to a fluid-sealing closure position.

Description

Closure cap for sterilization or filling of a medical device

[0001] The invention relates to a closure cap for the sterilization or aseptic filling of medical devices, in particular for the sterilization of dialyzers and dialysis treatment sets. In particular, the invention relates to a medical device with a fluid connection and a closure cap according to the invention.

[0002] Medical devices such as dialyzers and treatment sets, tubing sets for dialysis and in particular for extracorporeal blood treatment are used in the treatment of patients in a variety of therapies. A prerequisite for the use of such medical devices in patient therapy is their sterility. To ensure the sterility of the medical devices, such medical devices are subjected to a heat sterilization process, in particular a steam sterilization process or a sterilization process using a sterilizing gas, such as ethylene oxide. To also ensure that dialyzers or other medical devices are highly free of particles when delivered, the fluid connections of the dialyzers are closed with caps during production after, for example, rinsing and sterilization steps have been carried out.Inline steam sterilization has become particularly popular for the sterilization of dialyzers in the interests of efficient industrial production, as described in various versions, for example in European patent application EP 0 427 055 A2 and international patent application WO 2018 / 104498 A9.

[0003] During inline steam sterilization, finished dialyzers are clamped to a rinsing and sterilization device via the fluid connections. The dialyzers are then rinsed in several rinsing steps, e.g. with water, via the blood connections and the dialysate connections of the dialyzer. This process flushes unwanted residues from the production of the dialyzers, such as particles, residual solvents or residual polymer, from the interior of the dialyzer. In a further step, the dialyzer is sterilized, usually using superheated steam, at e.g. 121°C. For this purpose, the superheated steam is passed over the blood and / or or dialysate connections into the interior of the dialyzer, thus sterilizing the interior of the dialyzer.

[0004] For this sterilization process, precautions must be taken to ensure that the dialyzers cannot be recontaminated via the still-open blood and dialysate connections once they are removed from the flushing and sterilization device. To counteract this, sealing caps were developed that connect a dialyzer to the flushing and sterilization device via the blood and dialysate connections in a fluid- and germ-tight manner. These caps are functionally designed to close the blood and dialysate connections when the dialyzer is removed from the flushing and sterilization device.

[0005] In addition, closure caps for fluid connections on medical devices, especially a dialyzer, are also useful for resealing the medical device after use in a therapeutic procedure. After completion of, for example, extracorporeal blood treatment, the dialyzer may still be partially filled with treatment fluid and / or blood. For hygiene reasons in particular, it is important to ensure that the area surrounding a patient's treatment station is not contaminated with residual treatment fluid and / or the patient's blood when dismantling the dialysis machine and treatment device. It is therefore important to reseal the used dialyzer.

[0006] In this context, it should be noted that commercially available dialyzers typically have two fluid connections for blood. Furthermore, such dialyzers have at least one fluid connection for a treatment fluid or for the filtrate resulting from extracorporeal blood treatment. Typically, the dialyzers addressed in this application have two fluid connections for blood and two fluid connections for a treatment fluid, e.g., a dialysis fluid. The geometric design of the fluid connections of a dialyzer is described in standards, e.g., DIN EN ISO 8637: March 2014. However, depending on the type of therapeutic procedure to be used or the geographical region, not all dialyzers need to be designed according to this standard.

[0007] In addition to the requirements for sterilizing medical devices, the process of aseptic filling also plays a significant role in medical technology. During the aseptic filling of a medical container, the container to be filled is filled with sterile or aseptically pretreated liquid. Such filling processes can be performed, for example, using a closure cap, which allows the medical container to be filled and closed under aseptic conditions.

[0008] The patent application EP 2 114 344 A2 describes a closure for filling and closing containers containing medical liquids and a method for filling a container with a medical liquid and closing the container, wherein a closure piece is arranged in a closure body of the closure, which closure piece is displaceable in a releasing position and a position closing the passage of the closure body.

[0009] The patent application EP 0 352 540 A2 describes a multi-part closure cap for fluid connections of a dialyzer, which consists of a first and a second cap part, wherein the first cap part can be attached to the fluid connection of the dialyzer and the second cap part can be moved between an open position, in which the passage of a sterilization medium takes place, and a closing movement. TASK

[0010] Based on the closure caps described in the prior art and taking into account the requirements of the existing processes for sterilizing and aseptic filling of medical articles, there is a need to develop alternative closure caps that are optimized in terms of manufacturing effort, handling and functionality and are functionally designed so that they can be used in a sterilization process or aseptic filling process and can seal the sterilized or filled medical article in a fluid-tight and thus germ-tight manner. SUMMARY OF THE INVENTION

[0011] In a first aspect of the invention, the object is achieved by a closure cap having the features of claim 1. Subclaims 2 to 13 give preferred embodiments.

[0012] In a second aspect of the invention, the object is achieved by a medical article comprising a fluid connection and a closure cap according to one of the claims 1 to 13.

[0013] In a third aspect of the invention, the object is achieved by the use of a closure cap having the features according to one of claims 1 to 13 for sterilization or aseptic filling. DESCRIPTION OF THE INVENTION

[0014] The closure cap described according to the first aspect of the invention is intended to be placed onto a fluid connection of a medical article. In an open position of the closure cap, the closure cap is suitable for introducing a fluid into the medical article. The fluid can be a sterilization medium, e.g. a gas such as ethylene oxide or superheated steam at 121 °C, or an aseptically or sterilized filling material, such as a medical liquid. In a closed position, the closure cap is suitable for closing the fluid connection of the medical article in a fluid-tight and germ-tight manner, in particular, for example, to close the fluid connections of a dialyzer and ensure sterility and freedom from particles in the dialyzer.In particular, the closure cap is designed to cooperate with a first fluid connection of a dialyzer in a fluid-tight and / or liquid-tight manner. If the connection between the closure cap and the fluid connection of the dialyzer is fluid-tight or liquid-tight, this connection is also germ-tight, ensuring sterility and freedom from particles. In particular, the closure cap can also be designed to cooperate with the blood connection and / or a dialysate connection of a dialyzer for extracorporeal blood treatment. cooperates in a liquid-tight manner.

[0015] Furthermore, the closure cap according to the invention with the features of the embodiments of the first aspect is also suitable for use as a connecting piece between a first fluid connection of a medical device, in particular a dialyzer, and a rinsing and sterilization device, in particular a device for inline sterilization. The closure cap according to the first aspect simplifies the process flow of an industrial rinsing and sterilization method. The closure cap has a receiving area via which a fluid-tight connection to a first fluid connection of a medical device, in particular a dialyzer, can be established.Furthermore, the closure cap according to the invention can be connected to a rinsing and sterilization device in order to introduce a sterilization medium into the medical article when the closure cap is in the open position, in particular to enable "inline" sterilization processes or a sterilization process using a sterilizing gas. Alternatively, the closure cap can also serve to establish a connection to a filling station when the closure cap is in the open position in order to fill a medical article, such as a medical container, with a medical fluid.

[0016] The open and closed positions of the closure cap according to the invention are enabled by a closure plug detachably attached to the closure cap. In the open position, the closure plug releases a fluid channel through the closure cap through which a sterilization medium or a medical filling material can flow. In the closed position of the closure plug, the fluid channel is blocked by the closure plug in a fluid-tight manner. The closure plug can be moved from the open position to the closed position by applying a force. In particular, appropriate means can be provided on the rinsing and sterilization device to move the closure plug from an open position to a closed position.

[0017] According to the present invention, the handling of the closure caps is also simplified during the therapeutic procedures. When using the closure caps according to the invention in a dialyzer in an extracorporeal blood treatment procedure, they are inserted immediately before an extracorporeal Blood treatment of the dialyzer. Typically, after a patient's blood treatment, it is necessary to close the dialyzer's dialysate connections to prevent residual dialysate from leaking from the dialysate side of the dialyzer. The closure caps according to the invention can be used for this purpose. In one embodiment, the closure cap can be designed such that it can seal both the dialysate connection and the blood connection of a dialyzer in a fluid-tight manner. This enables smooth handling of the closure caps according to the invention during the setup and dismantling of a dialysis machine during extracorporeal blood treatment.

[0018] Further details, features and advantages of the invention will become apparent from the following description and the drawings: They show:

[0019] Fig.1 is a schematic representation of a side view of a closure cap according to the invention in the open position, in which the closure plug is detachably attached to the base body of the closure cap,

[0020] Fig.2 is a sectional view of a closure cap according to the invention along a central longitudinal axis A in the open position of the closure cap, in which the closure plug is detachably attached to the base body of the closure cap,

[0021] Fig. 3 is a sectional view of a closure cap according to the invention along a central longitudinal axis A in the closed position of the closure cap in which the closure plug blocks the fluid channel of the closure cap in a fluid-tight manner. DETAILED DESCRIPTION OF THE INVENTION

[0022] In the following, the invention is described using individual embodiments and illustrated with reference to Figs. 1 to 3, wherein the individual embodiments described are not limited to the embodiments shown in Figs. 1 to 3.

[0023] In a first aspect, the invention relates to a closure cap 100 for a fluid connection of a medical article, in particular for a liquid connection of a dialyzer, comprising a base body 101 and a closure plug 130, wherein the base body and closure plug are arranged along a central longitudinal axis A and adjoin one another, the base body 101 comprising a circumferential side wall 103 with an inner side 103A and an outer side 103B, an end wall 108 with an inner side 108A and an outer side 108B, a fluid channel 104 arranged centrally symmetrically to the first circumferential side wall 103, comprising a circumferential wall 105 with an inner side 105A directed towards the fluid channel and an outer side 105B directed towards the inner side 103A of the circumferential side wall 103, a first open end 106 and a second open end 107 for the passage of fluids, wherein the circumferential side wall 103 is connected circumferentially via the end wall 108 in a fluid-tight manner to the outer side 105B of the wall 105 of the fluid channel 104, characterized in thatthat the closure plug 130 is detachably or slidably attached to the base body and the closure plug 130 is dimensioned such that the closure plug 130 can be introduced into the fluid channel 105 from an open position in which a fluid can flow through the first open end 106 into the fluid channel into a fluid-tight closed position.

[0024] In the context of the present invention, a "dialyzer" is understood to mean a hollow-fiber membrane filter for extracorporeal blood treatment, which has at least two fluid connections for blood and at least one further fluid connection for dialysate or filtrate. In the context of the present invention, the term "dialyzer" refers to hollow-fiber membrane filters used in extracorporeal blood treatment. In particular, in the context of the present application, the term "dialyzer" also refers to hollow-fiber membrane filters used as blood treatment filters in dialysis, hemodiafiltration, hemofiltration, plasma separation, or blood oxygenation.

[0025] For the purposes of this application, a "closure cap" is understood to mean a closure element that seals an opening of a fluid connection of a medical device in a closed position in a fluid-tight manner. For the purposes of this application, "fluid-tight" means that a fluid, e.g., a rinsing liquid or a sterilization gas, such as superheated steam, cannot pass through a component section of the closure cap in the usual application of the closure cap. or through an opening closed by the cap.

[0026] The term "superheated steam" is used in the context of this application as equivalent to the technically common terms "moist heat" or "saturated steam". For the purposes of this application, this refers to gaseous water with a temperature above 100°C. In addition, during the steam sterilization of medical articles, a pressure is applied that accelerates and improves the sterilization process. Such pressures are between 1 and 5 bar. For the purposes of this application, the terms "superheated steam" 1 , “moist heat” or “saturated steam” also includes gaseous water with a temperature of 110 to 130°C, in particular 121°C, and a pressure of 1 to 5 bar, in particular 2.5 bar.

[0027] In the context of the present application, the term “base body” is understood to mean a component section of the closure cap which encloses a receiving area for a fluid connection of a medical article, i.e. is particularly intended to cooperate in a fluid-tight manner with a fluid connection of a medical article.

[0028] The term "circumferential sidewall" in the context of the present application refers to a sidewall that runs along a circumference. In this sense, a line that runs around the sidewall and is uninterrupted can be depicted on a circumferential sidewall. The circumferential sidewall can have sections that are essentially cylindrical in shape, such as an inner or outer side. Furthermore, the circumferential sidewall can have shoulders, projections, or cross-sectional changes. In certain embodiments, the circumferential sidewall is geometrically designed to cooperate in a fluid-tight manner with the fluid connection of a medical device, in particular a dialysate connection of a dialyzer.

[0029] In the context of the present application, the term “end wall” is understood to mean a component section that connects the circumferential side wall circumferentially and in a fluid-tight manner to the centrally symmetrically arranged fluid channel.

[0030] The term "receiving area" in the context of the present application is understood to mean a section of the closure cap into which a fluid connection of a medical article, in particular the dialysate connection or the blood connection of a dialyzer, can be inserted in a fluid-tight manner. The receiving area can, for example, be defined by the area formed by the The wall of the fluid channel can then be introduced into the opening of a fluid connection of a medical device, in particular the opening of the dialysate connection of a dialyzer. Alternatively, the closure cap can also be designed such that the fluid channel can accommodate a geometrically different fluid connection of a medical device, e.g., the blood connection of a dialyzer.

[0031] The term "closure plug" refers to a component body that can be fully or partially inserted into the fluid channel of the closure cap and can thus block the fluid channel in a fluid-tight manner. In the basic state of the closure cap, i.e. after manufacture, the closure plug is initially detachably connected to the base body of the closure cap. In this state, a fluid can flow through the fluid channel, which is arranged centrally and symmetrically to the first circumferential side wall, via the first open end and the second open end of the fluid channel. If a fluid can flow through the fluid channel, the closure plug and thus also the closure cap are in an "open position" within the meaning of the present application.If the closure plug has been inserted into the fluid channel in a fluid-tight position, the closure plug and thus also the closure cap are in a “closed position” within the meaning of the present application.

[0032] For the purposes of this application, the term "detachable connection" refers to a connection between the base body and the closure plug that can be released with a defined amount of force. In particular, a detachable connection can also be understood as a predetermined breaking point, whereby the connection can be broken with a defined amount of force without impairing the function of the closure cap. The connection can also be displaceable. Such embodiments comprise a material for the connection between the closure plug and the base body with particularly high elasticity.

[0033] A central longitudinal axis is understood to be a geometric axis of the closure cap, which runs centrally through the centrally symmetrically arranged fluid channel and in the sense of the translational movement of the closure plug in the centrally symmetrically arranged fluid channel from an open position to a closed position, defines a longitudinal extension of the closure cap.

[0034] In a further embodiment of the first aspect of the invention, the closure cap is characterized in that the closure plug is detachably attached to the end wall 108, in particular to the outer side 108A of the end wall 108 or to the first open end of the fluid channel 106 on the peripheral wall 105. A corresponding embodiment is illustrated by Figs. 1 and 2.

[0035] In a further embodiment of the first aspect of the invention, the closure cap is characterized in that the closure plug has a section with lateral passage openings 131 through which a fluid can flow in the open position of the closure plug and which, in a closed position, are covered in a fluid-tight manner by the inside of the wall of the fluid channel. According to this embodiment, fluid can be guided through the fluid channel through the lateral openings in the closure plug in the open position of the closure cap. It is advantageous that the closure plug can be introduced into the fluid channel 104 and the lateral openings are covered in a fluid-tight manner by the inside 105A of the wall 105 of the channel 104 in the closed position. In particular, in this embodiment, the closure plug can be countersunk into the channel 104.

[0036] In a further embodiment of the first aspect of the invention, the closure cap is characterized in that the wall 105 of the fluid channel 104, which is arranged centrally and symmetrically to the first circumferential side wall 103, has a substantially cylindrical inner side 105A. According to this embodiment, in order to ensure a fluid-tight and germ-tight closed position of the closure plug in the fluid channel, the closure plug is also cylindrical in sections so that the closure plug can be inserted into the channel in a fitting and fluid-tight manner. In particular, the cylindrical shape of the fluid channel and the closure plug is advantageous in terms of a germ-tight seal between the closure plug and the inner side 105A of the wall 105 of the fluid channel 104.

[0037] In particular, according to this embodiment, the closure plug is designed such that the closure plug has a cylindrical section 134 with an outer side 134A, which, in the closed position of the closure plug, cooperates in a fluid-tight manner with the cylinder jacket-shaped inner side 105A of the wall 105 of the fluid channel 104 arranged centrally symmetrically to the first circumferential side wall 103.

[0038] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that, in the open position of the closure plug, the closure plug 130 is connected to the wall 105 at the first open end of the fluid channel 106 via one or more sections of a detachable connection 132. According to one embodiment, the detachable connection can be connected circumferentially to the wall at the first open end of the fluid channel 106. In alternative embodiments, the circumferentially detachable connection can be interrupted into several sections of detachable connections. If several sections of detachable connection are circumferentially connected to the wall 105 at the first open end of the fluid channel 106, a lateral through-opening can advantageously be arranged on the closure plug between each section.

[0039] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that, in the open position of the closure plug, the closure plug 130 laterally has a plurality of circumferential crenellations 133 which adjoin the wall 105 at the first open end of the fluid channel 106 via sections of detachable connection 132.

[0040] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that the one or more sections of a detachable connection 132 are detachable with a force of 10 to 100 N, in particular of 20 to 60 N, more particularly of 25 to 45 N. In particular, according to this embodiment, the detachable connections are sufficiently stable to withstand the mechanical and thermal demands of the closure caps in rinsing and sterilization processes or alternatively in filling processes. In addition, the force is dimensioned such that the closure caps remain manageable in their functionality in accordance with the aforementioned procedures.

[0041] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that the one or more sections of a detachable connection 132 consist of an adhesive connection, a snap-in connection, or a weakened material portion. Adhesive connections or heat-sealed connections are particularly suitable for use as an adhesive connection. Particularly advantageously, the detachable connection consists of a weakened material portion that can be broken open with a defined force. This has the advantage that the closure cap can be manufactured in one piece in the open position, e.g., using an injection molding process, which is a particularly simple manufacturing method. Furthermore, the closure cap can be constructed in two parts in the closed position.

[0042] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that the inner side 105A of the wall 105 of the fluid channel 104 has a shoulder that reduces the clear width of the fluid channel 104. The shoulder thus forms a stop and defines a penetration depth of the closure plug 130 in the fluid channel 104 in the closed position. Due to the defined penetration depth of the closure plug, it can be visually recognized, for example, that the closure plug has achieved a sufficient penetration depth in the fluid channel 104 and that the closure cap thus meets the requirements for fluid and germ tightness in the closed position.

[0043] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that the closure cap has an annular shoulder 109 on the outer side 108B of the end wall. Preferably, the one or more sections of the detachable connections 132 adjoin this annular shoulder. Such an embodiment is shown in Figures 2 and 3. The annular shoulder advantageously serves to establish a fluid connection to a fluid connection of a filling, rinsing, or sterilization device. In this embodiment, the annular shoulder 109 can be inserted into the opening of a fluid connection a filling, rinsing, or sterilization device, thus creating a fluid- and germ-tight connection between the closure cap and the filling, rinsing, or sterilization device. When the closure cap is in the open position, a fluid can be introduced into the fluid channel 104 and further into the medical article, in particular the dialyzer, via the filling, rinsing, or sterilization device. After the filling, rinsing, or sterilization steps have been completed, the closure plug can be brought into the closed position using a stamping tool, which can be part of the filling, rinsing, or sterilization device. In the process, the one or more detachable connections between the base body and the closure plug are broken, and the closure plug is inserted into the channel 104.

[0044] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that the receiving area 102 is geometrically designed such that it can cooperate in a fluid-tight manner with a blood connection and / or a dialysate connection according to DIN EN ISO 8637: March 2014 of a dialyzer.

[0045] In a further embodiment of the first aspect of the invention, the closure cap 100 is characterized in that the closure cap is made of a plastic material selected from the group of thermoplastics, in particular polyethylene, polypropylene, or thermoplastic elastomers, or mixtures or copolymers thereof. Polypropylene homopolymers and copolymers are particularly preferred. Such materials are dimensionally stable, particularly during heat sterilization, and are therefore suitable for cooperating with a fluid connection of a medical device, in particular with the dialysate and blood connections of a dialyzer, in a germ- and fluid-tight manner at high temperatures.

[0046] In a second aspect, the invention relates to a medical article comprising at least one fluid connection provided with a closure cap according to one of the embodiments of the first aspect. The medical article can be, in particular, a dialyzer, a tubing set for dialysis, a treatment set for dialysis, or a container for holding medical fluids.

[0047] Furthermore, in a third aspect, the invention relates to the use of a closure cap according to one of the embodiments according to the first aspect for rinsing, sterilizing or aseptically filling a medical article. REFERENCE SYMBOLS OF THE FIGURES A Longitudinal axis 100 caps 101 Base body of the closure cap 102 Mounting area for a fluid connection 103 circumferential side wall 103A Inside of the peripheral side wall 103B Outside of the peripheral side wall 104 Fluid channel 105 circumferential wall of the fluid channel 105A Inside of the circumferential fluid channel 105B Outside of the circumferential fluid channel 106 first open end of the fluid channel 107 second open end of the fluid channel 108 End wall of the peripheral side wall 108A Inside of the end wall of the peripheral side wall 108B Outside of the end wall of the peripheral side wall 109 ring-shaped heel 130 sealing plugs 131 side openings on the closure plug 132 detachable connection between base body and cap 133 crenellations of the cap 134 cylindrical section of the sealing plug 134A Outside of the cylindrical section of the sealing plug

Claims

CLAIMS 1 . Closure cap (100) for a fluid connection of a medical article, in particular for a fluid connection of a dialyzer, comprising a base body (101) and a closure plug (130), wherein the base body and closure plug are arranged along a central longitudinal axis (A) and adjoin one another, the base body (101) comprising a circumferential side wall (103) with an inner side (103A) and an outer side (103B), an end wall (108) with an inner side (108A) and an outer side (108B), a fluid channel (104) arranged centrally symmetrically to the first circumferential side wall (103), comprising a circumferential wall (105) with an inner side (105A) directed towards the fluid channel and an outer side (105B) directed towards the inner side (103A) of the circumferential side wall (103), a first open end (106) and a second open end (107) for Passing fluids,wherein the circumferential side wall (103) adjoins the outer side (105B) of the wall (105) of the fluid channel (104) via the end wall (108) in a fluid-tight manner, characterized in that the closure plug (130) is attached to the base body via a detachable or displaceable connection (132) and the closure plug (130) is dimensioned such that the closure plug (130) can be introduced into the fluid channel (105) from an open position in which a fluid can flow into the fluid channel through the first open end (106) into a fluid-tight closed position.

2. Closure cap according to claim 1, characterized in that the closure plug is detachably attached to the end wall 196 or to the first open end of the fluid channel (106) on the peripheral wall (105).

3. Closure cap according to claim 1 or 2, characterized in that the closure plug has a section with lateral passage openings (131) through which a fluid can flow in the open position of the closure plug and which are covered in a fluid-tight manner by the inside of the wall of the fluid channel in a closed position.

4. Closure cap according to one of the preceding claims, characterized in that the wall (105) of the fluid channel (104) arranged centrally symmetrically to the first circumferential side wall (103) has a substantially cylindrical jacket-shaped inner side (105A).

5. Closure cap according to claim 4, characterized in that the closure plug has a cylindrical section (134) with an outer side (134A) which, in the closed position of the closure plug, cooperates in a fluid-tight manner with the cylinder jacket-shaped inner side (105A) of the wall (105) of the fluid channel (104) arranged centrally symmetrically to the first circumferential side wall (103).

6. Closure cap according to one of the preceding claims, characterized in that in the open position of the closure plug, the closure plug (130) is connected to the wall (105) at the first open end of the fluid channel (106) via one or more sections of a detachable connection (132).

7. Closure cap according to claim 6, characterized in that in the open position of the closure plug, the closure plug (130) has a plurality of circumferential crenellations (133) on the side, which adjoin the wall (105) at the first open end of the fluid channel (106) circumferentially via sections of detachable connection (132).

8. Closure cap according to one of claims 6 or 7, characterized in that the one or more sections of a releasable connection (132) are releasable with a force of 10 to 100 N.

9. Closure cap according to one of claims 6 to 8, characterized in that the one or more sections of a detachable connection (132) consist of an adhesive connection, a snap-in connection, or a material weakening.

10. Closure cap according to one of the preceding claims, characterized in that the inner side (105A) of the wall (105) of the fluid channel (104) has a shoulder which reduces the clear width of the fluid channel (104). 11 . Closure cap according to one of the preceding claims, characterized in that the closure cap is in one piece in the open position.

12. Closure cap according to one of the preceding claims, characterized in that the wall (105) of the fluid channel (104) projects beyond the end wall (108) and forms an annular shoulder (109) on the end wall (108) of the closure cap.

13. Closure cap according to one of the preceding claims, characterized in that the receiving area (102) is geometrically designed such that it cooperates in a fluid-tight manner with a blood connection and / or a dialysate connection according to DIN EN ISO 8637: March 2014 of a dialyzer.

14. A medical article comprising at least one fluid connection provided with a closure cap according to one of claims 1 to 13.

15. Use of a closure cap according to one of claims 1 to 13 for rinsing, sterilizing or aseptically filling a medical article.

Images