Smarca2 degraders and uses thereof

Abstract

The present disclosure provides compounds represented by Formula (A), or a pharmaceutically acceptable salt and / or stereoisomer thereof: (A), wherein Ra, Rb, R7, R8, R9, R10, R12, R12a, R12b, R12c, m, X3, W, L, and E are as defined in the specification. Compounds represented by Formula (A) are SMARCA2 protein degraders and are thus useful for treating cancer and other diseases.

Description

SMARCA2 DEGRADERS AND USES THEREOFBACKGROUNDField

[0001] The present disclosure provides Proteolysis Targeting Chimera (PROTAC) compounds and the use of such PROTAC compounds for the treatment of diseases or disorders dependent on SMARCA2 in mammals. Degradation of SMARCA2 may provide, for example, an anti-tumor effect. The present disclosure thus provides the use of SMARCA2 degraders and pharmaceutical compositions comprising SMARCA2 degraders for the treatment of cancer. It also provides intermediate compounds that may be useful in the preparation of such PROTACs.Background

[0002] Traditional "small molecule" drugs reversibly (or sometimes irreversibly) bind to a target protein as a means of modulating a given biological activity. In contrast, PROTACs bind to their target proteins reversibly, but then bring about the target protein's degradation. Having achieved this effect, the PROTAC is in theory able to repeat this process with another target protein. Accordingly, unlike traditional small molecule inhibitors, the PROTAC-driven degradation mechanism can in theory operate in a sub- stoichiometric manner - meaning that more modest exposures of a PROTAC compound could still achieve a desired level of efficacy in vivo. In practice, this means that the degradation power (DC50 and Dmax) of a PROTAC may have an improved effect over that reflected by its binding affinity.

[0003] PROTAC molecules are described as having three parts - (1) a part that is capable of binding to the protein to be degraded, (2) a second part that is capable of binding to an E3 ubiquitin ligase, and (3) a linker that connects parts (1) and (2) together. In use, the PROTAC binds to both the target protein and E3 ubiquitin ligase simultaneously to form a ternary complex. The E3 ligase then recruits an E2 conjugating enzyme to the ternary complex, which ubiquitinates the target protein. This has the effect of labelling the target protein for degradation by the cell's proteasome machinery. A PROTAC can then dissociate from the target protein and initiate another cycle of this process in a catalytic manner. Meanwhile, the ubiquitinated target proteins are recognized by the cell's proteasome machinery and are then degraded by it. This PROTAC-mediated approach may be valuable as a method of treating certain diseases, including cancer.

[0004] SMARCA4 is a frequently mutated in several tumor types - including lung, liver, colon, skin, bladder, esophageal, gastric, brain, endometrial, cervical and ovarian cancers. Furthermore, it has been established that SMARCA2 is essential for growth of tumors harboring such SMARCA4 mutations. Accordingly, selective suppression of SMARCA2 has been proposed as a therapeutic strategy against cancers that may include SMARCA4 mutations. Accordingly, selective suppression of SMARCA2 may be useful against a number of cancer types, including lung, liver, colon, skin, bladder, esophageal, gastric, brain, endometrial, cervical and ovarian cancers.

[0005] WO2019 / 207538 discloses certain PROTAC compounds described as "SMARCA 2 / 4 degraders" and W02020251969 discloses PROTAC compounds which target one or more of SMARCA2, SMARCA4 and PB1. W02019 / 195201 also discloses 'bifunctional' compounds described as modulators of SMARCA2. WO2019 / 213005 relates to compounds that are said to degrade PBRM1. WO2018 / 144649 and WO2021 / 053495 also disclose certain PROTAC molecules. WO2021 / 053555 discloses glue degrader compounds which bind to the E3 ubiquitin ligase, cereblon.

[0006] As part of developing a PROTAC against cancer, there is a need to develop further PROTAC compounds with a combination of beneficial / improved properties that make them more suitable for use as a therapeutic drug for human use. Properties of interest during pharmaceutical discovery and development may relate to selectivity profile, absorption / bioavailability, distribution, metabolism, elimination, toxicity and side-effect profile, stability, manufacturability and so on.BRIEF SUMMARY

[0007] In one aspect, the present disclosure provides PROTAC compounds represented by any one of Formulae (A), (IA), or (I)-(XVI), below, and the pharmaceutically acceptable salts thereof, or stereoisomers thereof. In another aspect, the present disclosure provides any one or more of the PROTAC compounds of Compound List 1, below, and the pharmaceutically acceptable salts thereof or stereoisomers thereof. In another aspect, the present disclosure provides any one or more of the PROTAC compounds of Compound List 2, below, and the pharmaceutically acceptable salts thereof. In another aspect, the present disclosure provides any one or more of the PROTAC compounds of Compound List 3, below, and the pharmaceutically acceptable salts thereof. In another aspect, the present disclosure provides any one or more of the PROTAC compounds of Compound List 4, below, and the pharmaceutically acceptable salts thereof. In another aspect, the present disclosure provides any one or more of the PROTAC compounds of Compound List 5, below, and the pharmaceutically acceptable salts thereof. Compounds having any one of Formulae (A), (IA), or (I)-(XVI), and the pharmaceutically acceptable salts thereof, or stereoisomers thereof, and the PROTAC compounds of Compound List 1, Compound List 2, Compound List 3, Compound List 4 and / or Compound List 5, and the pharmaceutically acceptable salts thereof, or stereoisomers thereof, are collectively referred to as "Compounds of the Disclosure" or individually as a "Compound of the Disclosure." Compounds of the Disclosure exhibit protein degradation activity against SMARCA2. Compounds of the Disclosure also may have a beneficial degree of selectivity to minimize certain undesirable off-target degradation activities. As such, Compounds of the Disclosure may be useful in the treatment of cancer.

[0008] Compounds of the Disclosure also may have a surprisingly beneficial combination of properties of relevance in the context of pharmaceutical discovery and development. Structural features found in all three regions of a PROTAC have the potential to operate (collectively or in some cases separately) towards delivering a beneficial combination and / or balance of such additional beneficial properties. Avoidance ofoff-target activity in pharmaceutical development is often important to avoid or reduce unwanted toxicities, side-effects or other problems with tolerability when used in patients

[0009] As well as being degraders of SMARCA2, Compounds of the Disclosure have a surprising and beneficial combination of properties relating, for example, to chemical and metabolic stability, e.g. in human microsomes and to hydrolysis at pH 7.4, and selectivity against SALL4 and / or Ikaros (IKZF1) - which is expected to provide an improved safety profile for use in vivo. Without wishing to be bound by any particular theory, it is believed that degradation of SALL4 and Ikaros (IKZF 1) amongst others may risk serious unwanted effects in humans, for example, developmental toxicities or bone marrow toxicities.

[0010] Also, in this regard, it has been found that molecules that degrade SMARCA2 can often also degrade SMARCA4, which is regarded as an undesirable off-target activity. Compounds of the Disclosure may show a beneficial selectivity profile by achieving a potent degree of degradation against SMARCA2 while having a margin of selectivity, i.e., relatively lower degradation, against SMARCA4. In a similar manner in the development of a SMARCA2 PROTAC for use in cancer, it is also regarded as beneficial to have a potent degree of degradation against SMARCA2 while having a good margin of selectivity, i.e., relatively lower degradation, against PBRM1. Compounds of the Disclosure may show a beneficial selectivity profile between SMARCA2 and PBRM1. Thus, in combination, Compounds of the Disclosure may show high potency against SMARCA2 while simultaneously achieving a beneficial selectivity profile with respect to SALL4 and / or Ikaros (IKZF1), and in some cases a surprisingly beneficial margin of selectivity against SMARCA4 and / or PBRM1.

[0011] In another aspect, the present disclosure provides pharmaceutical compositions comprising a Compound of the Disclosure and one or more pharmaceutically acceptable excipients.

[0012] In another aspect, the present disclosure provides methods of degrading SMARCA2 protein in a human, comprising administering to a human in need thereof an effective amount of a Compound of the Disclosure.

[0013] In another aspect, the present disclosure provides methods of reducing SMARCA2 protein in a human, comprising administering to a human in need thereof an effective amount of a Compound of the Disclosure.

[0014] In another aspect, the present disclosure provides methods of treating cancer in a human, comprising administering to a human in need thereof an effective amount of a Compound of the Disclosure.

[0015] In another aspect, the present disclosure provides a Compound of the Disclosure, or pharmaceutical composition thereof, for use in degrading SMARCA2 protein in a human.

[0016] In another aspect, the present disclosure provides a Compound of the Disclosure, or pharmaceutical composition thereof, for use in reducing SMARCA2 protein in a human.

[0017] In another aspect, the present disclosure provides a Compound of the Disclosure, or pharmaceutical composition thereof, for use in treating cancer in a human.

[0018] In another aspect, the present disclosure provides use of a Compound of the Disclosure, or pharmaceutical composition thereof in the manufacture of a medicament for degrading SMARCA2 protein in a human.

[0019] In another aspect, the present disclosure provides use of a Compound of the Disclosure, or pharmaceutical composition thereof in the manufacture of a medicament for reducing SMARCA2 protein in a human.

[0020] In another aspect, the present disclosure provides use of a Compound of the Disclosure, or pharmaceutical composition thereof in the manufacture of a medicament for treating cancer in a human.

[0021] In another aspect, the present disclosure provides methods of preparing Compounds of the Disclosure.

[0022] In another aspect, the present disclosure provides intermediates used to prepare Compounds of the Disclosure.

[0023] Additional embodiments and advantages of the disclosure will be set forth, in part, in the description that follows, and will flow from the description, or can be learned by practice of the disclosure. The embodiments and advantages of the disclosure will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims. It is to be understood that both the foregoing summary and the following detailed description are exemplary and explanatory only, and are not restrictive of the invention as claimed.DETAILED DESCRIPTIONI. Compounds of the Disclosure

[0024] Many embodiments of this disclosure are detailed throughout the specification.

[0025] In one embodiment, Compounds of the Disclosure are compounds having Formula (A), or pharmaceutically acceptable salt and / or stereoisomer thereof:wherein:

[0026] E is:

[0027] R1is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or

[0028] R2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or

[0029] with the provisos:

[0030] (i) when R1is hydrogen, halogen, (Ci-C6)alkyl, or (Ci-Ce)alkoxy, then R2is:

[0031] (ii) when R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R1is:

[0032] R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;

[0033] X1is CR3orN;

[0034] R3is hydrogen, halogen, or (Ci-Ce)alkyl;

[0035] X2is CR4or N;

[0036] R4is hydrogen, halogen, or (Ci-Ce)alkyl;

[0037] R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;

[0038] R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;

[0039] R6is hydrogen, (Ci-Ce)alkyl, or cyano;

[0040] X3is -(CR13aR13b)n- or -O-;

[0041] n is 0 or 1

[0042] each R13aand R13bis independently hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[0043] L is -G1-G2-G3-G4-, wherein G1is attached to W;

[0044] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;

[0045] G2is (Ci-Ce)alkylenyl, -C(=O)-, or a direct bond;

[0046] G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;

[0047] G4is (Ci-C6)alkylenyl or a direct bond;

[0048] W is -C(=O)-, -CH2-, or a direct bond;

[0049] R7is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0050] R8is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0051] R9is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0052] R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0053] each R12is independently halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[0054] m is 0, 1, 2, 3, or 4;

[0055] R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen; or

[0056] R12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl;

[0057] R12cis hydrogen or halogen;

[0058] Rais hydrogen or halogen; and

[0059] Rbis hydrogen or halogen.

[0060] In another embodiment, Compounds of the Disclosure are compounds having Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof:(I), wherein:

[0061] E is:

[0062] R1is hydrogen, halogen, (Ci-C6)alkyl, (Ci-Ce)alkoxy, or

[0063] R2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, orwith the provisos:

[0064] (i) when R1is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R2is:

[0065] (ii) when R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R1is:

[0066] R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;

[0067] X1is CR3or N;

[0068] R3is hydrogen, halogen, or (Ci-C6)alkyl;

[0069] X2is CR4or N;

[0070] R4is hydrogen, halogen, or (Ci-Ce)alkyl;

[0071] R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;

[0072] R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;

[0073] R6is hydrogen, (Ci-Ce)alkyl, or cyano;

[0074] X3is -(CR13aR13b)n- or -O-;

[0075] n is 0 or 1

[0076] each R13aand R13bis independently H, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[0077] L is -G^GF-G -G4-, wherein G1is attached to W;

[0078] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[0079] G2is (Ci-Ce)alkylenyl or a direct bond;

[0080] G3is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[0081] G4is (Ci-C6)alkylenyl or a direct bond;

[0082] W is -C(=O)-;

[0083] R7is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[0084] R8is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[0085] R9is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[0086] R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0087] each R12is independently halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy; and

[0088] m is 0, 1, 2, 3, or 4.

[0089] In another embodiment, Compounds of the Disclosure are compounds having Formula (IA), or pharmaceutically acceptable salt and / or stereoisomer thereof:wherein:

[0090] E is:

[0091] R1is hydrogen, halogen, (Ci-C6)alkyl, (Ci-Ce)alkoxy, or

[0092] R2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, orwith the provisos:

[0093] (i) when R1is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R2is:

[0094] (ii) when R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R1is:

[0095] R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;

[0096] X1is CR3orN;

[0097] R3is hydrogen, halogen, or (Ci-Ce)alkyl;

[0098] X2is CR4or N;

[0099] R4is hydrogen, halogen, or (Ci-Ce)alkyl;

[0100] R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;

[0101] R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;

[0102] R6is hydrogen, (Ci-Ce)alkyl, or cyano;

[0103] X3is -(CR13aR13b)n- or -O-;

[0104] n is 0 or 1

[0105] each R13aand R13bis independently hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[0106] L is -G^GF-G -G4-, wherein G1is attached to W;

[0107] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-Ce)alkoxy, or cyano;

[0108] G2is (Ci-C6)alkylenyl, -C(=O)-, or a direct bond;

[0109] G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[0110] G4is (Ci-C6)alkylenyl or a direct bond;[oni] W is -C(=O)-, -CH2-, or a direct bond;

[0112] R7is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[0113] R8is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0114] R9is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0115] R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[0116] R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen; or

[0117] R12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl ; and

[0118] R12cis hydrogen or halogen.

[0119] In another embodiment, Compounds of the Disclosure are compounds having Formula (II):

[0120] wherein R7, R8, R9, R12, m, E, L, and X3are as defined in connection with Formula (I).

[0121] In another embodiment, Compounds of the Disclosure are compounds having Formula (III):

[0122] wherein R7, R8, R9, R12, m, E, L, and X3are as defined in connection with Formula (I).

[0123] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein X3is -(CR13aR13b)-.

[0124] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein R13a and R13b are hydrogen.

[0125] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein R13a and R13b are fluoro.

[0126] In another embodiment, Compounds of the Disclosure are compounds having any one Formulae (A), (IA), or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein R13a is methyl or methoxy; and R13b is hydrogen.

[0127] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein X3 is -O-.

[0128] In another embodiment, Compounds of the Disclosure are compounds having any one Formulae (A) or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein m is 0.

[0129] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A) or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein m is 2.

[0130] In another embodiment, Compounds of the Disclosure are compounds having any one Formulae (A) or (I)-(III), or a pharmaceutically acceptable salt thereof, wherein m is 1.

[0131] In another embodiment, Compounds of the Disclosure are compounds having Formula (IV):(IV),

[0132] wherein R7, R8, R9, R12, E, L, and X3are as defined in connection with Formula (I).

[0133] In another embodiment, Compounds of the Disclosure are compounds having Formula (V):

[0134] wherein R7, R8, R9, R12, E, L, and X3are as defined in connection with Formula (I).

[0135] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A) or (I)-(V), or a pharmaceutically acceptable salt thereof, wherein each R12is fluoro, methyl, ethyl, or methoxy.

[0136] In another embodiment, Compounds of the Disclosure are compounds having Formula (VIII):

[0137] wherein R7, R8, R9, R10, R12a, R12b, R12c, X3, W, L, and E are as defined in connection with Formula (IA).

[0138] In another embodiment, Compounds of the Disclosure are compounds having Formula (IX):

[0139] wherein R7, R8, R9, R10, R12a, R12b, R12c, X3, W, L, and E are as defined in connection with Formula (IA).

[0140] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), (VIII), or (IX), or a pharmaceutically acceptable salt thereof, wherein R12ais hydrogen and R12bis hydrogen, fluoro, methyl, ethyl, or methoxy.

[0141] In another embodiment, Compounds of the Disclosure are compounds having Formula (X):wherein:

[0142] X4is O;

[0143] d and e are independently 1 or 2; and

[0144] R7, R8, R9, R10, X3, W, L, and E are as defined in connection with Formula (IA).

[0145] In another embodiment, Compounds of the Disclosure are compounds having Formula (XI):wherein:

[0146] X4is O;

[0147] d and e are independently 1 or 2; and

[0148] R7, R8, R9, R10, X3, W, L, and E are as defined in connection with Formula (IA).

[0149] In another embodiment, Compounds of the Disclosure are compounds having Formula (XII):(XII), wherein:

[0150] X4is O;

[0151] d and e are independently 1 or 2; and

[0152] R7, R8, R9, R10, X3, W, L, and E are as defined in connection with Formula (IA).

[0153] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein E is E- 1.

[0154] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais hydrogen.

[0155] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais (Ci-Ce)alkyl optionally substituted with one, two, or three substituents independently selected from halogen or cyano.

[0156] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais methyl, ethyl, isopropyl, or -CF3.

[0157] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais (C3-C6)cycloalkyl.

[0158] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais cyclopropyl.

[0159] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais 4- to 6-membered heterocycloalkyl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[0160] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais cyano.

[0161] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais aryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[0162] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5ais 5- or 6-membered heteroaryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[0163] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein E is E-2.

[0164] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5bis hydrogen.

[0165] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5bis (Ci-C6)alkyl.

[0166] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5bis methyl.

[0167] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof wherein R5bis (C3-C6)cycloalkyl.

[0168] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R5bis cyclopropyl or cyclobutyl.

[0169] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R6is hydrogen.

[0170] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R6is (Ci-C6)alkyl.

[0171] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R6is cyano.

[0172] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein:

[0173] R1is:

[0174] R2is hydrogen, halogen, (Ci-C6)alkyl, or (Ci-C6)alkoxy.

[0175] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R2is hydrogen, halogen, or (Ci-C6)alkyl.

[0176] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R2is hydrogen, fluoro, or methyl.

[0177] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R11is hydrogen.

[0178] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein:

[0179] R2is:

[0180] R1is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-C6)alkoxy.

[0181] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R1is hydrogen, halogen, or (Ci-C6)alkyl.

[0182] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R1is hydrogen, fluoro, or methyl.

[0183] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R11is hydrogen.

[0184] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein X1is CR3.

[0185] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R3is hydrogen.

[0186] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R3is halogen.

[0187] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R3is fluoro.

[0188] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R3is (Ci-C6)alkyl.

[0189] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R3is methyl.

[0190] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein X1is N.

[0191] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein X2is CR4.

[0192] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R4is hydrogen.

[0193] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R4is halogen.

[0194] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R4is fluoro.

[0195] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R4is (Ci-C6)alkyl.

[0196] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R4is methyl.

[0197] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein X2is N.

[0198] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein E-l is:

[0199] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein E-l is:

[0200] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein E-2 is:

[0201] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G1is 4-to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[0202] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein:

[0203] G1is:

[0204] each R14is independently halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano;

[0205] n is 0, 1, 2, or 3; and

[0206] the bond marked with an "*" is attached to G2.

[0207] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein n is 0.

[0208] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R14is fluoro, methyl, or methoxy; and n is 1, or 2.

[0209] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G1is:

[0211] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G1is(C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[0212] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G1is a 7- to 11 -membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[0213] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G1is:

[0214] the bond marked with an “*” is attached to G2.

[0215] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G2is a direct bond.

[0216] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G2is (Ci-C6)alkylenyl.

[0217] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G2is - CH2- or -CH(CH3)-.

[0218] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G2is - C(=O)-.

[0219] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V) or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[0220] In another embodiment, Compounds of the Disclosure are compounds having any one of F

[0221] the bond marked with an "*" is attached to G4.

[0222] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V) or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is:

[0223] the bond marked with an "*" is attached to G4.

[0224] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[0225] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is:

[0226] the bond marked with an “*” is attached to G4.

[0227] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is 7- to 11 -membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[0228] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is:

[0229] the bond marked with an "*" is attached to G4.

[0230] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein:

[0231] G3is:

[0232] each R15is independently selected from halogen, (Ci-C6)alkyl, (Ci-Ce)alkoxy, or cyano;

[0233] u is 0, 1, 2, or 3;

[0234] v, w, x, and t are independently 1, 2, or 3; and

[0235] the bond marked with an "*" is attached to G4.

[0236] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein v, w, x, and y are independently 1 or 2.

[0237] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is:

[0238] the bond marked with an "*" is attached to G4.

[0239] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V) or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is:

[0240] the bond marked with an "*" is attached to G4.

[0241] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V) or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G3is (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[0242] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G4is (Ci-C6)alkylenyl.

[0243] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein G4is a direct bond.

[0244] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein L is:

[0245] the bond marked with an "*" is attached to E.

[0246] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein L is:

[0247] the bond marked with an "*" is attached to E.

[0248] In another embodiment, Compounds of the Disclosure are compounds having any one ofFormulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R7is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[0249] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R7is halogen or (Ci-C6)alkyl.

[0250] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R7is fluoro or methyl.

[0251] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R8, R9, and R10are hydrogen.

[0252] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R8is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[0253] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R8is halogen or (Ci-C6)alkyl.

[0254] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R8is fluoro or methyl.

[0255] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R7, R9, and R10are hydrogen.

[0256] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R9is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[0257] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R9is halogen.

[0258] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R9is fluoro.

[0259] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R7, R8, and R10are hydrogen.

[0260] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R10is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[0261] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R10is halogen.

[0262] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R10is fluoro.

[0263] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R7, R8, and R9are hydrogen.

[0264] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (I)-(V), or (VIII)-(XII), or a pharmaceutically acceptable salt thereof, wherein R7, R8, R9, and R10are hydrogen.

[0265] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (VIII), or (IX), or a pharmaceutically acceptable salt thereof, wherein R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[0266] In another embodiment, Compounds of the Disclosure are compounds having any one of Formulae (A), (IA), (VIII), or (IX), or a pharmaceutically acceptable salt thereof, wherein R12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7- membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl.

[0267] In another embodiment, Compounds of the Disclosure are compounds having Formulae (A), wherein Rais fluoro and Rbis hydrogen.

[0268] In another embodiment, Compounds of the Disclosure are compounds having Formulae (A), wherein Rais hydrogen and Rbis fluoro.

[0269] In another embodiment, Compounds of the Disclosure are compounds having Formula (VI):wherein:

[0270] R15ais fluoro;

[0271] p is 0, 1, or 2;

[0272] Z1is CR15borN;

[0273] R15bis hydrogen, fluoro, methyl, or methoxy;

[0274] R16is hydrogen or methyl;

[0275] Z2is CH or N;

[0276] R17is fluoro or methyl;

[0277] q is 0, 1, or 2;

[0278] R12is fluoro, methyl, ethyl, or methoxy; and m is 1; or R12is hydrogen; and m is 0;

[0279] R7, R8, R9, and R10are independently hydrogen, fluoro, chloro, methyl, -CF3, cyclopropyl, methoxy, or cyano; and

[0280] X3and E are as defined in connection with Formula (I).

[0281] In another embodiment, Compounds of the Disclosure are compounds having Formula (VII):wherein:

[0282] R15ais fluoro;

[0283] p is 0, 1, or 2;

[0284] Z1is CR15borN;

[0285] R15bis hydrogen, fluoro, methyl, or methoxy;

[0286] R16is hydrogen or methyl;

[0287] Z2is CH or N;

[0288] R17is fluoro or methyl;

[0289] q is 0, 1, or 2;

[0290] R12is fluoro, methyl, ethyl, or methoxy; and m is 1; or R12is hydrogen; and m is 0;

[0291] R7, R8, R9, and R10are independently hydrogen, fluoro, chloro, methyl, -CF3, cyclopropyl, methoxy, or cyano; and

[0292] X3and E are as defined in connection with Formula (I).

[0293] In another embodiment, Compounds of the Disclosure are compounds having Formula (XIII):(XIII), wherein:

[0294] R7, R8, R9, and R10are independently hydrogen or methyl;

[0295] R12aand R12bare independently hydrogen or methyl;

[0296] R15ais fluoro;

[0297] p is 0, 1, or 2;

[0298] Z1is CR15bor N;

[0299] R15bis hydrogen or fluoro;

[0300] Z2is CH or N;

[0301] R17is fluoro;

[0302] q is 0, 1, or 2; and

[0303] E is as defined in connection with Formula (IA).

[0304] In another embodiment, Compounds of the Disclosure are compounds having Formula (XIV):(XIV), wherein:

[0305] R7, R8, R9, and R10are independently hydrogen or methyl;

[0306] R12aand R12bare independently hydrogen or methyl;

[0307] R15ais fluoro;

[0308] p is 0, 1, or 2;

[0309] Z1is CR15bor N;

[0310] R15bis hydrogen or fluoro;

[0311] Z2is CH or N;

[0312] R17is fluoro;

[0313] q is 0, 1, or 2; and

[0314] E is as defined in connection with Formula (IA).

[0315] In another embodiment, Compounds of the Disclosure are compounds having Formula (XV):wherein:

[0316] Raand Rbare independently hydrogen or fluoro;

[0317] R7, R8, R9, and R10are independently hydrogen or methyl;

[0318] R12aand R12bare independently hydrogen or methyl; or

[0319] R12aand R12btaken together with the carbon atoms to which they are attached form a5-membered heterocycloalkyl;

[0320] Z3is CH orN.

[0321] Z4is CR15bor N;

[0322] R15bis hydrogen or fluoro;

[0323] Z5is CH orN; and

[0324] E is as defined in connection with Formula (A).

[0325] In another embodiment, Compounds of the Disclosure are compounds having Formula (XV), wherein R12aand R12bare independently hydrogen or methyl.

[0326] In another embodiment, Compounds of the Disclosure are compounds having Formula (XVI):(XVI),

[0327] wherein Ra, Rb, R7, R8, R9, R10, Z3, Z4, Z5, and E are as definied in connection with Formula (XV).

[0328] In another embodiment, Compounds of the Disclosure are any one or more of the compounds of Compound Lists 1-5, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof. In the Compound Lists, a compound having an "*" in its chemical name indicates that the absolute configuration and / or relative configuration at that position of the molecule has not yet been confirmed. For example, "ethyl (R*)-4-(pyrrolidin-3-yl)benzoate" indicates that the compound may be ethyl ( / ?)-4-(pyrrolidin-3- yl)benzoate or ethyl (.S')-4-(pyrrolidin-3-yl)bcnzoatc. See Intermediates 18d and 18de of EXAMPLE 18. It is to be understood that if a compound has two or more "*" in its chemical name the compound may be one of the several possible stereoisomers, e.g., entantiomers and / or diastereomers. Thus, for example, " 1 -( 1-(1- (( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione" indicates the compound may be l-(l-(l-((l-(4-((3R,5R)-l-(3-amino-6-(2- hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4- yl)methyl)piperidin-4-yl)- lH-indol-5-yl)dihydropyrimidine-2,4( lH,3H)-dione or 1 -( 1 -( 1 -(( 1 -(4-((3S,5S)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidin-3-yl)-3-methylbenzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione. See EXAMPLE 29. Likewise, " l -( l -( l -(((3 / ?.4 / ?)- l -(4-(( / ?*)-4-(3-Amino-6-(2-hydroxyphcnyl)pyridazin-4- yl)morpholin-2-yl)-3-mcthylbcnzoyl)-3-fliioropipcridin-4-yl)mcthyl)pipcridin-4-yl)-3-cyclopropyl- l / / - pyrrolo[2,3- / ?]pyridin-5-yl)dihydropyrimidine-2,4( l / / .3 / / )-dionc" indicates the compound may be 1 -( l-( 1- (((3R,4R)-l-(4-((R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)- 3 -fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo 12.3 - / ? | py ridi n-5 - yl)dihydropyrimidine-2,4( I / / .3 / / )-dionc or 1 -( 1 -( 1 -(((3R,4R)- 1 -(4-((S)-4-(3-Amino-6-(2- hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-3-fluoropiperidin-4- yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- / ?]pyridin-5-yl)dihydropyrimidine-2,4(dione. See EXAMPLE 142.

[0329] In another embodiment, Compounds of the Disclosure are any one or more of the compounds of Compound List 1, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.Compound List 1

[0330] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0331] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0332] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0333] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0334] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0335] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0336] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0337] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0338] (R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l -methyl- lH-indol-6-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0339] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0340] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0341] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0342] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - ethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0343] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-(trifluoromethyl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0344] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4,6-difluoro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0345] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0346] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0347] (S * )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)pyrrolidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0348] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)pyrrolidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0349] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0350] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0351] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0352] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0353] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0354] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0355] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl- lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0356] (R)-3 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0357] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0358] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0359] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0360] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0361] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0362] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0363] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0364] (R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-lH-pyrrolo[3,2-b]pyridin-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0365] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0366] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0367] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0368] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0369] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0370] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0371] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0372] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0373] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0374] rac- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0375] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0376] (R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)- 1 -methyl- lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0377] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0378] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0379] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0380] (R)-2-(l-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-5-(4-((4-(3- cyclopropyl-5 -(2,4-dioxotetrahydropyrimidin- 1 (2H)-yl)- IH-pyrrolo [2,3 -b]pyridin- 1 -yl)piperidin- 1 - yl)methyl) -4-fluoropiperidine - 1 -carbonyl)benzonitrile ;

[0381] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0382] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0383] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2-(trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)meth*yl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0384] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0385] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 -(trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0386] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl) -3 - fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0387] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methoxybenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0388] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-5-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0389] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine -2,4(1 H, 3H) -dione ;

[0390] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0391] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0392] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0393] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0394] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0395] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0396] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0397] (R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-lH-pyrrolo[3,2-b]pyridin-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0398] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0399] (R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-7-fluoro-lH-indol-6-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0400] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine2,4(lH,3H)-dione;

[0401] (R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l -methyl- lH-indol-6-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0402] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0403] (R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l -cyclobutyl- lH-indol-6-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0404] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0405] (S)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0406] ( S ) — 1 — ( 1 — ( 1 — ( ( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0407] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0408] (R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-7-fluoro-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0409] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0410] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0411] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0412] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0413] l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0414] l-(l-(l-((l-(4-((3R*,5R*)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0415] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0416] (S)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0417] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0418] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0419] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0420] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0421] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0422] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0423] l-(l-(l-((l-(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0424] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0425] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-isopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0426] (R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)- 1 -cyclobutyl- lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0427] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0428] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0429] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0430] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0431] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0432] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0433] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0434] rac- 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0435] rac- 1 -( 1 -( 1 -(( 1 -(4-((3R,5 S)- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0436] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0437] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0438] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0439] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0440] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0441] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3,4-dimethyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0442] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0443] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0444] l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0445] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0446] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0447] 1 -( 1 -(( 1 S,4s)-4-((4-(4-((R)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0448] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl) -3 - methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0449] 1 -( 1 -(( 1 R,4r)-4-((4-(4-((R)- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0450] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-methylpiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0451] 1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0452] rac- 1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0453] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 ,5 - difluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0454] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0455] 1 -( 1 -(( 1 R,3 s,5 S)-8-(( 1 -(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0456] 1 -( 1 -(( 1 R,3 s,5 S)-8-(( 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0457] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5 S *)- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0458] (R)- 1 -( 1 -(( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)azetidin-3-yl)methyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0459] 1 -( 1 -( 1 -(- 1 -( 1 -(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)ethyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0460] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4,6-difluoro-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0461] l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0462] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0463] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0464] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0465] l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0466] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0467] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0468] (R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l -cyclobutyl- lH-indol-6-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0469] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3 -methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0470] 1 -( 1 -( 1 -(( 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl) -3 ,3 -difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0471] 1 -( 1 -( 1 -(((3R,4R)- 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-3-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0472] (R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-l,2-dimethyl-lH-indol-7-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0473] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0474] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0475] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0476] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0477] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,5 -difluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0478] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0479] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0480] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0481] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0482] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0483] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; or

[0484] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)yridazine-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione.

[0485] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0486] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0487] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0488] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl- lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0489] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0490] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0491] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0492] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0493] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0494] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0495] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0496] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0497] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0498] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0499] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0500] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0501] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0502] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0503] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0504] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0505] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0506] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0507] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0508] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0509] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0510] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0511] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0512] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0513] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R*)- 1 -(3-amino-6-(2-hydroxyphenyl)yridazine-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0514] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0515] l-(l-((lR,4r)-4-((4-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0516] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)yridazine-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0517] l-(l-(l-((l-(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0518] l-(l-(l-((l-(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0519] l-(l-(l-((l-(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0520] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0521] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0522] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0523] l-(l-(l-((l-(4-((2S,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0524] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0525] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0526] 1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0527] 1 -( 1 -( 1 -(((R* )- 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0528] 1 -( 1 -( 1 -(((R* )- 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0529] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0530] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0531] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0532] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0533] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0534] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0535] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0536] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0537] 1 -( 1 -( 1 -(((R* )- 1 -(4-((R)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0538] 1 -( 1 -( 1 -(((S* )- 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0539] 1 -( 1 -(- 1 -(( 1 -(4-((R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0540] 1 -( 1 -( 1 -(((R* ) - 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl) -3 ,3 -difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0541] 1 -( 1 -( 1 -(((R*)- 1 -(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0542] 1 -( 1 -( 1 -(((R*)- 1 -(4-((S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0543] 1 -( 1 -( 1 -(((R* ) - 1 -(4-((R)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0544] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0545] 1 -( 1 -((3 S,4S* ,5R)- 1 -(( l-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0546] l-(l-((lS,4s)-4-((4-(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0547] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0548] rel-(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0549] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0550] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0551] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0552] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0553] 1 -( 1 -( 1 -(( 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0554] rel- 1 -( 1 -(( lR,4r)-4-((4-(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0555] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0556] 1 -( 1 -((S * )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0557] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0558] 1 -( 1 -((S * )- 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0559] 1 -( 1 -((S * )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0560] l-(l-((lR,4r)-4-((4-(4-((R)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3- yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0561] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; or

[0562] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione.

[0563] In another embodiment, Compounds of the Disclosure are any one or more of the compounds of Compound List 2, or a pharmaceutically acceptable salt thereof, or stereoisomer thereof.Compound List 2

[0564] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0565] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0566] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-4-fhroro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0567] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0568] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-6-fhroro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0569] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0570] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0571] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0572] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0573] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0574] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl- lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0575] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0576] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0577] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0578] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0579] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0580] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0581] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0582] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0583] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0584] rac- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0585] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0586] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0587] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0588] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0589] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0590] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0591] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0592] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0593] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0594] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0595] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine2,4(lH,3H)-dione;

[0596] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0597] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0598] (S)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0599] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0600] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0601] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0602] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0603] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0604] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0605] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0606] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0607] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0608] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0609] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0610] l-(l-(l-((l-(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0611] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0612] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0613] l-(l-(l-((l-(4-((3R*,5R*)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0614] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0615] l-(l-(l-((l-(4-((3R*,5R*)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0616] l-(l-(l-((l-(4-((3R*,5R*)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0617] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0618] rac- 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0619] rac- 1 -( 1 -( 1 -(( 1 -(4-((3R,5 S)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0620] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0621] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0622] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3,4-dimethyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0623] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0624] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0625] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0626] l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0627] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0628] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0629] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0630] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0631] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0632] 1 -( 1 -( 1 -(( 1 -(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl) -3 ,3 -difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0633] 1 -( 1 -( 1 -(((3R,4R)- 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-3-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0634] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0635] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0636] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0637] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0638] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,5 -difluoropiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0639] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0640] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0641] (R*)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0642] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0643] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0644] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0645] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)yridazine-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0646] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0647] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0648] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0649] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0650] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0651] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0652] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0653] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0654] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0655] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0656] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0657] (R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0658] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0659] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0660] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0661] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R*)- 1 -(3-amino-6-(2-hydroxyphenyl)yridazine-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0662] l-(l-((lR,4r)-4-((4-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0663] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)yridazine-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0664] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0665] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0666] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0667] 1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0668] 1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0669] 1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0670] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0671] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0672] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0673] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0674] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0675] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0676] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0677] 1 -( 1 -( 1 -(((R*)- 1 -(4-((R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0678] 1 -( 1 -( 1 -(((S * ) - 1 -(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0679] 1 -( 1 -(- 1 -(( 1 -(4-((R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0680] 1 -( 1 -( 1 -(((R*)- 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0681] 1 -( 1 -( 1 -(((R*)- 1 -(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0682] 1 -( 1 -( 1 -(((R*)- 1 -(4-((S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0683] 1 -( 1 -( 1 -(((R*)- 1 -(4-((R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0684] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0685] l-(l-((3S,4S*,5R)-l-((l-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4- yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3- cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0686] l-(l-((lS,4s)-4-((4-(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0687] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0688] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0689] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0690] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)-1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0691] l-(l-(l-((l-(4-((3R*,5R*)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol- 5-yl)dihydropyrimidine-2,4(lH,3H) -dione;

[0692] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0693] 1 -( 1 -((S*)- 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0694] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0695] 1 -( 1 -((S*)- 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0696] 1 -( 1 -((S * )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0697] l-(l-((lR,4r)-4-((4-(4-((R)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3- yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0698] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; or

[0699] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione.

[0700] In another embodiment, Compounds of the Disclosure are any one or more of the compounds of Compound List 3, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.Compound List 3

[0701] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0702] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - ethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0703] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-(trifluoromethyl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0704] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-4-yl)-4,6-difhroro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0705] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2,5- dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5-yl)dihydropyrimidine-2,4(lH,3H) -dione;

[0706] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0707] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0708] (R)-3 -( 1 -( 1 -(( 1 -(4-( 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0709] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0710] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0711] l-(l-(l-((l-(4-((3R*,5R*)-l-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0712] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0713] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0714] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0715] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0716] (R)-2-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-5 -(4-((4-(3 - cyclopropyl-5 -(2,4-dioxotetrahydropyrimidin- 1 (2H)-yl)- IH-pyrrolo [2,3 -b]pyridin- 1 -yl)piperidin- 1 - yl)methyl) -4-fluoropiperidine - 1 -carbonyl)benzonitrile ;

[0717] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2-(trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)meth*yl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0718] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0719] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 -(trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0720] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl) -3 - fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0721] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methoxybenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0722] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0723] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0724] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0725] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-isopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0726] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0727] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0728] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0729] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0730] 1 -( 1 -(( 1 S,4s)-4-((4-(4-((R)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0731] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl) -3 - methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0732] l-(l-((lR,4r)-4-((4-(4-((R)-l-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0733] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-methylpiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0734] 1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0735] rac- 1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0736] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0737] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5 S *)- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0738] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0739] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0740] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0741] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0742] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0743] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0744] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0745] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0746] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0747] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0748] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0749] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0750] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0751] 1 -( 1 -( 1 -(( 1 -(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0752] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0753] l-(l-(l-((l-(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0754] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0755] 1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl- lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0756] 1 -( 1 -( 1 -(( 1 -(4-((2S,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0757] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0758] rel-(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0759] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0760] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0761] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione; or

[0762] 1 -( 1 -( 1 -(( 1 -(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione.

[0763] In another embodiment, Compounds of the Disclosure are any one or more of the compounds of Compound List 4, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.Compound List 4

[0764] 1 -( 1 -((S)- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)pyrrolidin-3-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0765] 1 -( 1 -((3 S * ,4R* )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0766] 1 -( 1 -((S)- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-3-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0767] (R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0768] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2-fluoro-5-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0769] 1 — ( 1 — ( ( S ) — 1 — ( ( 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)pyrrolidin-3-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0770] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0771] 1 -( 1 -((S * )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)azepan-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0772] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2-chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0773] (R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0774] l-(l-(l-(((lR,5S,8S)-3-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3-azabicyclo[3.2.1]octan-8-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0775] l-(l-(l-(((lR,5S,8S)-3-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)-3-azabicyclo[3.2.1]octan-8-yl)methyl)piperidin-4-yl)-3-methyl- lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0776] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0777] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0778] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0779] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH- indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0780] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0781] (S * )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0782] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0783] (R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0784] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0785] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0786] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0787] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-5-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0788] l-(l-((lS,4s)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- y 1) -3 -methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione

[0789] l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- y 1) -3 -methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0790] l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)-2-methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0791] l-(l-((lR,4r)-4-((4-(4-((2R*,5R*,6S*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0792] l-(l-((lS,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0793] l-(l-((lS,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0794] l-(l-((lS,4s)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)-2,5-dimethylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0795] l-(l-((lS,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0796] rac-l-(l-((lR,4r)-4-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0797] l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)-2,5-dimethylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0798] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0799] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0800] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0801] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0802] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0803] l-(l-((lR,4r)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0804] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0805] l-(l-(l-((l-(4-((2R*,5R*,6S*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0806] rac- 1 -( 1 -( 1 -(( 1 -(4-((2R,5R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0807] 1 -( 1 -( 1 -(( 1 -(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0808] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0809] 1 -( 1 -( 1 -(( 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)-3 ,3 -difluoropiperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0810] 1 -( 1 -((S * )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0811] l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)-2,5-dimethylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0812] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0813] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0814] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0815] l-(l-(l-((l-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0816] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0817] 1 -( 1 -( 1 -(( 1 -(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][l,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0818] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0819] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2,6-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0820] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0821] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0822] 1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0823] l-(l-((lR,4r)-4-((4-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4- yl)hexahydro-2H-furo [3 ,4-b] [ 1 ,4] oxazin-2 -yl)benzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0824] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0825] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0826] 1 -( 1 -( 1 -(( 1 -(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][l,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0827] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2,6-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0828] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0829] 1 -( 1 -( 1 -(( 1 -(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][l,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0830] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-2,6-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0831] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0832] (R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-7-fluoro-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0833] 1 -( 1 -( 1 -(( 1 -(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0834] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0835] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0836] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0837] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0838] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0839] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - fluoropiperidin-3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;

[0840] 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 - methoxypiperidin-3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl- lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0841] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0842] (R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0843] 1 -( 1 -( (R) - 1 -((1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)pyrrolidin-3-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0844] l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0845] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0846] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0847] (R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,3 - dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0848] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0849] (R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0850] 1 -( 1 -((S * )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)azepan-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0851] 1 -( 1 -( 1 -(( 1 -(4-((2R* ,6R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-(fluoromethyl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0852] 1 -( 1 -(( 1 S,4s)-4-((4-(4-((R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0853] (R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0854] (R)- 1 -( 1 -( 1 -( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzyl)-4- fluoropiperidine-4-carbonyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;

[0855] 1 -( 1 -((S * )- 1 '-(4-((R)- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - methylbenzoyl)-[l,3'-bipiperidin]-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;

[0856] (R* )- 1 -( 1 -(7 -((1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0857] (R* )- 1 -( 1 -(7 -((1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;

[0858] l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; or

[0859] l-(l-(l-((l-(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione.

[0860] In another embodiment, Compounds of the Disclosure are any one or more of the compounds of Compound List 5, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.Compound List 5

[0861] 1 -( 1 -((3S,4R)- 1 -(( 1 -(4-((22?,65)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-127- pyrrolo| 2.3- / ? |pyridin-5-yl)dihydropyrimidinc-2.4( 17 / .37 / )-dionc:

[0862] 1 -( 1 -((3 R, 45)- 1 -(( 1 -(4-((22?,65)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 1 / -py rrolo [2,3 - 7]pyridin-5-yl)dihydropyrimidine-2, 4(127, 327)-dione;

[0863] 1 -( 1 -((3S,42?)- 1 -(( 1 -(4-((22?,65)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 1 / -py rrolo [2,3 - 7]pyridin-5-yl)dihydropyrimidine-2, 4(127, 327)-dione;

[0864] l-(l-((12?,4r)-4-((4-(4-((22?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -ethyl- 127-py rrolo [2,3 -A | py ridi n-5 - yl)dihydropyrimidine-2,4( 1 73 0-dione:

[0865] l-(l-((2r,52?)-2-((4-(4-((22?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5 -dimethylbenzoyl)piperazin- 1 -yl)methyl)- 1 ,3 -dioxan-5 -yl) -3 -methyl- 127-indol- 5-yl)dihydropyrimidine-2, 4(127, 327) -dione;

[0866] 1 -( 1 -((32?,42?) - 1 -(( 1 -(4-((22?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 127-pyrrolo [2,3 - 7]pyridin-5-yl)dihydropyrimidine-2, 4(127, 327)-dione;

[0867] 1 -( 1 -((3S,45)- 1 -(( 1 -(4-((22?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 127-pyrrolo [2,3 - 7]pyridin-5-yl)dihydropyrimidine-2, 4(127, 327)-dione;

[0868] 1 -( 1 -((32?, 42?)- 1 -(( 1 -(4-((22?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 127-pyrrolo [2,3 - 7]pyridin-5-yl)dihydropyrimidine-2, 4(127, 327)-dione;

[0869] 1 -( 1 -((3S,42?)- 1 -(( 1 -(4-((22?,65)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 127-pyrrolo [2,3 - 7]pyridin-5-yl)dihydropyrimidine-2, 4(127, 327)-dione;

[0870] 1 -( 1 -((3S,45)- 1 -(( 1 -(4-((22?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-127-pyrrolo[2,3- 7]pyridin-5-yl)dihydropyrimidine-2, 4(127, 327)-dione;

[0871] l-(l-((12?,45)-4-((4-(4-((2?)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-2-methyl-127-indol-4-yl)dihydropyrimidine-2, 4( 127,327)-dione;

[0872] l-(l-((12?,45)-4-((4-(4-((lS)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 -methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-2 -methyl- 127-indol-4-yl)dihydropyrimidine- 2, 4( 127,370-dione;

[0873] 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0874] 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0875] 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0876] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5-yl)dihydropyrimidine- 2,4(1H,3H)-dione;

[0877] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0878] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0879] 1-(1-((2S,4s,6S)-6-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0880] 1-(1-((2R,4r,6R)-6-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0881] 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0882] 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0883] 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0884] 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0885] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0886] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0887] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0888] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0889] 1-(1-((1R,4r)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed));

[0890] 1-(1-((1R,4r)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed));

[0891] 1-(1-((1S,4s)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed));

[0892] 1-(1-((1S,4s)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed));

[0893] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0894] 1-(1-((3S,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0895] 1-(1-((3R,4R)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0896] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0897] 1-(1-((3S,4S)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0898] 1-(1-((3R,4R)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0899] 1-(1-((3S,4S)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0900] 1-(1-((3R,4R)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0901] 1-(1-((3S,4S)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0902] 1-(1-((3R,4R)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0903] 1-(1-((3S,4S)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0904] 1-(1-((3R,4R)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0905] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0906] 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0907] 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0908] 1-(1-((1R,4r)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0909] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0910] 1-(1-((1R,4r)-4-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0911] 1-(1-((1R,4r)-4-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0912] 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0913] 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0914] 1-(1-((3S,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0915] 1-(1-((3R,4R)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0916] 1-(1-((1R,4r)-4-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0917] 1-(1-((1R,4r)-4-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0918] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0919] l-(l-((lS,4s)-4-((4-(4-((2J?,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3-cyclopropyl- 17f-pyrrolo[ 2,3- 6]pyridin-5-yl)dihydropyrimidine-2, 4(127, 370-dione;

[0920] 1 -( 1 -((3 R, 45)- 1 -(( 1 -(4-((2J?,5J?)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 127-pyrrolo [2,3 - 6]pyridin-5-yl)dihydropyrimidine-2, 4(127, 370-dione;

[0921] 1 -( 1 -((35,42?)- 1 -(( 1 -(4-((2 / ?.5 / ?)-4-(3-Amino-6-(2-hydroxyphcnyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- 127-pyrrolo [2,3 - 6]pyridin-5-yl)dihydropyrimidine-2, 4(127, 322)-dione;

[0922] 1 -( 1 -((3 R, 45)- 1 -(( 1 -(4-((22?,52?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-127-pyrrolo[2,3- 6]pyridin-5-yl)dihydropyrimidine-2, 4(127, 322)-dione;

[0923] 1 -( 1 -((3 R, 45)- 1 -(( 1 -(4-((25,55,62?)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-127-pyrrolo[2,3- 6]pyridin-5-yl)dihydropyrimidine-2, 4(127, 322)-dione;

[0924] 1 -( 1 -((3 R, 45)- 1 -(( 1 -(4-((22?,52 -4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-127-pyrrolo[2,3- 6]pyridin-5-yl)dihydropyrimidine-2, 4(127, 322)-dione;

[0925] l-(l-((12?,4r)-4-((4-(4-((22?,52 -4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -ethyl- 127-pyrrolo [2,3 -A | py ridi n-5 - yl)dihydropyrimidine-2,4( 127,322)-dione;

[0926] 1 -( 1 -( 1 -(( 1 -(4-((22?,52?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-127-pyrrolo[2,3- 6]pyridin-5-yl)dihydropyrimidine-2, 4(127, 322)-dione;

[0927] 1 -( 1 -( 1 -(( 1 -(4-((25,55,62?)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-127-pyrrolo[2,3- / ? |pyridin-5-yl)dihydropyrimidinc-2.4( l7 / .37 / )-dionc:

[0928] l -( l -((2r.5 / ?)-2-((4-(4-((2 / ?.5 / ?)-4-(3-Amino-6-(2-hydroxyphcnyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin- 1 -yl)methyl)- 1 ,3 -dioxan-5 -yl) -3 -methyl- 127-pyrrolo [2,3 - / ? |pyridin-5-yl)dihydropyrimidinc-2.4( l7 / .37 / )-dionc:

[0929] l-(l-((15,45)-4-((4-(4-((22?,52?,65)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -ethyl- 127-pyrrolo 12.3 -A | py ridi n-5 - yl)dihydropyrimidine-2, 4(127, 32 )-dione;

[0930] l-(l-((15,45)-4-((4-(4-((25,55,62?)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -ethyl- 127-pyrrolo 12.3 -A | py ridi n-5 - yl)dihydropyrimidine-2, 4(127, 322)-dione;

[0931] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-5-yl)dihydropyrimidine- 2,4(1H,3H)-dione;

[0932] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0933] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0934] 1-(1-(1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0935] 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0936] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5-yl)dihydropyrimidine- 2,4(1H,3H)-dione;

[0937] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl- 1H-indol-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0938] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl- 1H-indol-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0939] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl-1H-indol- 5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0940] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl-1H-indol- 5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0941] 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0942] 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0943] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0944] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0945] 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0946] 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0947] 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0948] 1-(1-((3S,4R)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0949] 1-(1-((3S,4R)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0950] 1-(1-((3S,4R)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0951] 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0952] 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0953] 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-1H-indol-4- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0954] 1-(1-((3R,4S)-1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4- yl)hexahydro-2H-furo[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3- ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0955] 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0956] 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0957] 1-(1-((2r,5R)-2-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0958] 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0959] 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0960] 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0961] 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0962] 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0963] 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0964] 1-(1-((3R,4S)-1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4- yl)hexahydro-2H-furo[3,4-b][1,4]oxazin-2-yl)-2-methylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin- 4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,43H)-dione;

[0965] 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0966] 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0967] 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0968] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin- 2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0969] 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0970] 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0971] 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0972] 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0973] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(3-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0974] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(3,5-difluoro-2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0975] 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0976] 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;

[0977] 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(5-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; or

[0978] 1 -( 1 -( 1 -(( 1 -(4-((27?,4a7?,7aZ?)-4-(3 -Amino-6-(5 -fluoro-2-hydroxyphenyl)pyridazin-4- yl)hexahydro-2H-furo[3,4-6][l,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6- methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH, 3H) -dione.

[0979] In another embodiment, a Compound of the Disclosure is:

[0980] or a pharmaceutically acceptable salt thereof.

[0981] In another embodiment, a Compound of the Disclosure is:

[0982] or a pharmaceutically acceptable salt thereof.

[0983] In another embodiment, a Compound of the Disclosure is:

[0984] or a pharmaceutically acceptable salt thereof.

[0985] In another embodiment, a Compound of the Disclosure is:

[0986] or a pharmaceutically acceptable salt thereof.

[0987] In another embodiment, a Compound of the Disclosure is:

[0988] or a pharmaceutically acceptable salt thereof.

[0989] In another embodiment, a Compound of the Disclosure is:

[0990] or a pharmaceutically acceptable salt thereof.

[0991] In another embodiment, a Compound of the Disclosure is:

[0992] or a pharmaceutically acceptable salt thereof.

[0993] In another embodiment, a Compound of the Disclosure is:

[0994] or a pharmaceutically acceptable salt thereof.

[0995] In another embodiment, a Compound of the Disclosure is:

[0996] or a pharmaceutically acceptable salt thereof.

[0997] In another embodiment, a Compound of the Disclosure is:

[0998] or a pharmaceutically acceptable salt thereof.

[0999] In another embodiment, a Compound of the Disclosure is:

[1000] or a pharmaceutically acceptable salt thereof.

[1001] In another embodiment, a Compound of the Disclosure is:

[1002]

[1003]

[1004] or a pharmaceutically acceptable salt thereof.

[1005] In another embodiment, a Compound of the Disclosure is:

[1006] or a pharmaceutically acceptable salt thereof.

[1007] In another embodiment, a Compound of the Disclosure is:

[1008] or a pharmaceutically acceptable salt thereof.

[1009] In another embodiment, the present disclosure provides pharmaceutical compositions comprising a Compound of the Disclosure and one or more pharmaceutically acceptable excipients.

[1010] Compounds of the Disclosure may have one or more chiral centres and it will be recognised that such compounds may be prepared, isolated and / or supplied with or without the presence of one or more of the other possible enantiomeric and / or diastereomeric isomers of the compounds, or that such isomers may be provided in any relative proportions. The preparation of enantioenriched or enantiopure and / or diastereoenriched or diastereopure compounds may be carried out by standard techniques of organic chemistry that are well known in the art, for example by synthesis from enantioenriched or enantiopure starting materials, and / or by use of an appropriately enantioenriched or enantiopure catalyst during synthesis, and / or by resolution of a racemic or partially enriched mixture of stereoisomers, for example via chiral chromatography. The scope of the present disclosure includes mixtures of stereoisomers as well as purified enantiomers or enantiomerically / diastereomerically enriched mixtures. It is to be understood that the present disclosure includes all combinations and subsets of the particular groups defined hereinabove.[ion] In one embodiment, the present disclosure provides a composition comprising a Compound of the Disclosure optionally together with one or more of the other stereoisomeric forms of the compound, wherein the Compound of the Disclosure is present within the composition with a diastereomeric excess (%de) of > 55%.

[1012] In another embodiment, the %de in the above-mentioned composition is > 90%.

[1013] In another embodiment, the %de in the above-mentioned composition is > 95%.

[1014] In another embodiment, the %de in the above-mentioned composition is > 98%.

[1015] In another embodiment, the %de in the above-mentioned composition is > 99%.

[1016] In another embodiment, the present disclosure provides a composition comprising a Compound of the Disclosure optionally together with one or more of the other stereoisomeric forms of the compound, wherein the Compound of the Disclosure is present within the composition with an enantiomeric excess (%ee) of > 55%.

[1017] In another embodiment, the %ee in the above-mentioned composition is > 90%.

[1018] In another embodiment, the %ee in the above-mentioned composition is > 95%.

[1019] In another embodiment, the %ee in the above-mentioned composition is > 98%.

[1020] In another embodiment, the %ee in the above-mentioned composition is > 99%.

[1021] In another embodiment, the present disclosure provides a composition comprising a Compound of the Disclosure optionally together with one or more of the other stereoisomeric forms of the compound, wherein the Compound of the Disclosure is present within the composition with an enantiomeric excess (%ee) of > 90% and a diastereomeric excess (%de) of > 90%.

[1022] In another embodiment, the present disclosure provides a composition comprising a Compound of the Disclosure optionally together with one or more of the other stereoisomeric forms of the compound, wherein the the %ee and %de of the Compound of the Disclosure take any combination of values, e.g., the %ee is >5% and the %de is > 80%; the %ee is >5% and the %de is > 90%; the %ee is >5% and the %de is > 95%; the %ee is > 5% and the %de is > 98%; the %ee is > 95% and the %de is > 95%; the %ee is > 98% and the %de is > 98%; or the %ee is > 99% and the %de is > 99%.

[1023] The present disclosure encompasses the preparation and use of salts of Compounds of the Disclosure. Pharmaceutically acceptable salts include, amongst others, those described in Berge, J. Pharm. Sci., 66, 1-19, (1977) orthose listed in P.H. Stahl and C.G. Wermuth, editors, Handbook of Pharmaceutical Salts; Properties, Selection and Use, Second Edition Stahl / Wermuth: Wiley- VCH / VHCA (2011) (see http: / / www.wiley.com / WileyCDA / WileyTitle / productCd-3906390519.html).

[1024] Suitable pharmaceutically acceptable salts can include acid or base addition salts.

[1025] Such base addition salts can be formed by reaction of a Compound of the Disclosure with the appropriate base, optionally in a suitable solvent such as an organic solvent, to give the salt which can be isolated by a variety of methods, including crystallisation and fdtration.

[1026] Such acid addition salts can be formed by reaction of a Compound of the Disclosure with the appropriate acid, optionally in a suitable solvent such as an organic solvent, to give the salt which can be isolated by a variety of methods, including crystallisation and fdtration.

[1027] Salts may be prepared in situ during the final isolation and purification of a Compound of the Disclosure. If a basic compound of a Compound of the Disclosure is isolated as a salt, the corresponding free base form of that compound may be prepared by any suitable method known to the art, including treatment of the salt with an inorganic or organic base. Similarly, if a Compound of the Disclosure containing a carboxylic acid or other acidic functional group is isolated as a salt, the corresponding free acid form of that compound may be prepared by any suitable method known to the art, including treatment of the salt with an inorganic or organic acid.

[1028] It will be understood that if a Compound of the Disclosure contains two or more basic moieties, the stoichiometry of salt formation may include 1, 2 or more equivalents of acid. Such salts would contain 1, 2 or more acid counterions, for example, a dihydrochloride salt.

[1029] Stoichiometric and non-stoichiometric forms of a pharmaceutically acceptable salt of a Compound of the Disclosure are included within the scope of the specification, including sub -stoichiometric salts, for example where a counterion contains more than one acidic proton.

[1030] Representative pharmaceutically acceptable acid addition salts include, but are not limited to, 4-acetamidobenzoate, acetate, adipate, alginate, ascorbate, aspartate, benzenesulfonate (besylate), benzoate, bisulfate, bitartrate, butyrate, calcium edetate, camphorate, camphorsulfonate (camsylate), caprate (decanoate), caproate (hexanoate), caprylate (octanoate), cinnamate, citrate, cyclamate, digluconate, 2,5- dihydroxybenzoate, disuccinate, dodecylsulfate (estolate), edetate (ethylenediaminetetraacetate), estolate (lauryl sulfate), ethane- 1,2-disulfonate (edisylate), ethane sulfonate (esylate), formate, fumarate, galactarate (mucate), gentisate (2,5-dihydroxybenzoate), glucoheptonate (gluceptate), gluconate, glucuronate, glutamate, glutarate, glycerophosphorate, glycolate, hexylresorcinate, hippurate, hydrabamine (N,N'- di(dehydroabietyl)-ethylenediamine), hydrobromide, hydrochloride, hydroiodide, hydroxynaphthoate, isobutyrate, lactate, lactobionate, laurate, malate, maleate, malonate, mandelate, methanesulfonate (mesylate), methylsulfate, mucate, naphthalene-l,5-disulfonate (napadisylate), naphthalene-2-sulfonate (napsylate), nicotinate, nitrate, oleate, palmitate, p-aminobenzenesulfonate, p-aminosalicyclate, pamoate (embonate), pantothenate, pectinate, persulfate, phenylacetate, phenylethylbarbiturate, phosphate, polygalacturonate, propionate, p-toluenesulfonate (tosylate), pyroglutamate, pyruvate, salicylate, sebacate, stearate, subacetate, succinate, sulfamate, sulfate, tannate, tartrate, teoclate (8-chlorotheophyllinate), thiocyanate, triethiodide, undecanoate, undecylenate, and valerate.

[1031] Representative pharmaceutically acceptable base addition salts include, but are not limited to, aluminium, 2-amino-2-(hydroxymethyl)-l,3-propanediol (TRIS), arginine, benethamine (N- benzylphenethylamine), benzathine (N.N ’-dibenzylethylenediamine), A / .s-(2-hydroxycthyl)aminc. bismuth, calcium, chloroprocaine, choline, clemizole (1-p chlorobenzyl-2-pyrrolildine-r-ylmethylbenzimidazole), cyclohexylamine, dibenzylethylenediamine, diethylamine, diethyltriamine, dimethylamine, dimethylethanolamine, dopamine, ethanolamine, ethylenediamine, L-histidine, iron, isoquinoline, lepidine, lithium, lysine, magnesium, meglumine (JV-methylglucamine), piperazine, piperidine, potassium, procaine, quinine, quinoline, sodium, strontium, / -butylaminc. tromethamine ( / m(hydroxymcthyl)aminomcthanc). and zinc.

[1032] The present disclosure also includes isotopically-labeled compounds, which are identical to a Compound of the Disclosure except that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature. Examples of isotopes that can be incorporated into Compounds of the Disclosure include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, sulfur, fluorine, chlorine, and iodine, such as2H,3H,nC,13C,14C,15N,17O,18O,31P,32P,35S,18F,36C1,123I, and125I.

[1033] Compounds of the Disclosure that contain the aforementioned isotopes and / or other isotopes of other atoms are within the scope of the disclosure. Isotopically-labeled compounds of the disclosure, for example those into which radioactive isotopes such as3H,14C are incorporated, are useful in drug and / or substrate tissue distribution assays. Tritiated, i.e.,3H, and carbon-14, i.e.,14C, isotopes are particularly used for their ease of preparation and detectability.nC and18F isotopes are particularly useful in PET (positronemission tomography), and125I isotopes are particularly useful in SPECT (single photon emission computerized tomography), all useful in brain imaging. Further, substitution with heavier isotopes such as deuterium, i.e.,2H, can afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life or reduced dosage requirements and, hence, may be used in some circumstances. Isotopically labeled Compounds of the Disclosure can generally be prepared by carrying out the procedures disclosed in the Schemes and / or in the Examples below, by substituting a readily available isotopically labeled reagent for a non-isotopically labeled reagent.

[1034] In another embodiment, the present disclosure provides a pharmaceutical composition comprising a comprising a Compound of the Disclosure and one or more excipients (also referred to as carriers and / or diluents in the pharmaceutical arts). The excipients are acceptable in the sense of being compatible with the other ingredients of the formulation and not deleterious to the recipient thereof, i.e., the patient.II. Methods of Use

[1035] It is known that SMARCA4 mutations may be present in certain tumor / cancer types, including lung, liver, colon skin, bladder, cervical and ovarian tumors / cancers, and that SMARCA2 is essential for growth of tumors containing such SMARCA4 mutations. Accordingly, Compounds of the Disclosure may be of value as anti-cancer agents / anti-tumor agents, in particular against cancer / tumor types known to harbor SMARCA4 mutations, for example, lung cancer, liver cancer, colon cancer, skin cancer, bladder cancer, liver cancer, cervical cancer, and ovarian cancer.

[1036] Compounds of the Disclosure may also be of value against cancer types / tumors sensitive to the degradation of SMARCA2, for example, lung cancer, liver cancer, colon cancer, skin cancer, bladder cancer, liver cancer, cervical cancer, and ovarian cancer.

[1037] Compounds of the Disclosure may also be of value as anti-tumor agents, in particular as selective inhibitors of the proliferation, survival, motility, dissemination and invasiveness of mammalian cancer cells leading to inhibition of tumor growth and survival and to inhibition of metastatic tumor growth. In particular, Compounds of the Disclosure may be of value as anti -proliferative and anti-invasive agents in the containment and / or treatment of solid tumor disease.

[1038] Compounds of the Disclosure may also be useful in the prevention or treatment of those tumors which are sensitive to degradation of SMARCA2 and that are involved in the signal transduction steps which lead to the proliferation and survival of tumor cells and the migratory ability and invasiveness of metastasising tumor cells. Further, Compounds of the Disclosure may be useful in the prevention or treatment of those tumors which are mediated alone or in part by degradation of SMARCA2, i.e., the compounds may be used to produce an SMARCA2 degradation effect in a subject, e.g., a warm-blooded animal, e.g., a human, in need of such treatment.

[1039] In one embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of cancer.

[1040] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of a solid tumor.

[1041] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of a SMARCA2-sensitive tumor type.

[1042] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of tumor types that harbor SMARCA4 mutations.

[1043] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of lung, liver, colon, skin, bladder, cervical or ovarian cancer.

[1044] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of SMARCA4-mutated cancer.

[1045] The pharmaceutical compositions may be in a form suitable for oral use (for example as tablets, lozenges, hard or soft capsules, aqueous or oily suspensions, emulsions, dispersible powders or granules, syrups or elixirs) or for parenteral administration (for example as a sterile aqueous or oily solution for intravenous, subcutaneous or intramuscular dosing). The compositions may be obtained by conventional procedures using conventional pharmaceutical excipients that are well known in the art. Thus, compositions intended for oral use may contain, for example, one or more colouring, sweetening, flavouring and / or preservative agents. See, e.g., Chapter 25.2 in Volume 5 of Comprehensive Medicinal Chemistry (Corwin Hansch; Chairman of Editorial Board), Pergamon Press 1990.

[1046] The amount of the Compound of the Disclosure that is combined with one or more excipients to produce a single dosage form will necessarily vary depending upon the subject being treated and the particular route of administration.

[1047] The size of the dose for therapeutic or prophylactic purposes of Compounds of the Disclosure will naturally vary according to the nature and severity of the disease state, the age and sex of the animal or patient and the route of administration, according to well known principles of medicine.

[1048] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use as a medicament.

[1049] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in therapy.

[1050] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in a method of treatment of the human or animal body by therapy.

[1051] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the production of an anti -proliferative effect, for example, in a warm-blooded animal such as a human.

[1052] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for the production of an anti-proliferative effect, for example, in a warm-blooded animal such as a human.

[1053] In another embodiment, the present disclosure provides a method for producing an antiproliferative effect in a warm-blooded animal, such as man, in need of such effect, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof.

[1054] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use as an anti-invasive agent in the containment and / or treatment of solid tumor disease, for example, in a warm-blooded animal such as a human.

[1055] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for use as an anti- invasive agent in the containment and / or treatment of solid tumor disease, for example, in a warm-blooded animal such as a human.

[1056] In another embodiment, the present disclosure provides a method for producing an anti -invasive effect by the containment and / or treatment of solid tumor disease, in a warm-blooded animal, such as man, in need of such effect, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof.

[1057] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the prevention or treatment of cancer, for example, in a warmblooded animal such as a human.

[1058] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for the prevention or treatment of cancer, for example, in a warm-blooded animal such as a human.

[1059] In another embodiment, the present disclosure provides a method for the prevention or treatment of cancer in a warm-blooded animal, such as a human, in need of such treatment, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof.

[1060] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the prevention or treatment of solid tumor(s), for example, in a warm-blooded animal such as a human.

[1061] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for the prevention or treatment of solid tumor(s), for example, in a warm-blooded animal such as a human.

[1062] In another embodiment, the present disclosure provides a method for the prevention or treatment of solid tumor(s) in a warm-blooded animal, such as a human, in need of such treatment, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof.

[1063] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the prevention or treatment of tumor types that are sensitive to degradation of SMARCA2.

[1064] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for the prevention or treatment of those tumor types that are sensitive to degradation of SMARCA2.

[1065] In another embodiment, the present disclosure provides a method for the prevention or treatment of those tumor types that are sensitive to degradation of SMARCA2, in a warm-blooded animal, such as man, in need of such treatment, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof. Tumor types that are sensitive to degradation of SMARCA2 include, for example, lung tumor, liver tumor, colon tumor, skin tumor, bladder tumor, cervical tumor and ovarian tumor.

[1066] In another embodiment, the d present isclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in providing a degrading effect on SMARCA2, for example, in a warm-blooded animal such as a human.

[1067] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for providing a degrading effect on SMARCA2, for example, in a warm-blooded animal such as a human.

[1068] In another embodiment, the present disclosure provides a method for providing a degrading effect on SMARCA2 in a warm-blooded animal, such as man, in need of such effect, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof.

[1069] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in providing a selective degrading effect on SMARCA2 in, for example, a warm-blooded animal such as man.

[1070] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for providing a selective degrading effect on SMARCA2, for example, in a warm-blooded animal such as a human.

[1071] In another embodiment, the present disclosure provides a method for providing a selective degrading effect on SMARCA2 in a warm-blooded animal, such as man, in need of such effect, which comprises administering an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof. SMARCA2 has been found to be essential for growth of tumors containing SMARCA4 mutations and certain tumor / cancer types are associated with such SMARCA4 mutations.

[1072] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of tumor types that harbor SMARCA4 mutations.

[1073] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for the prevention or treatment of those tumor types that harbor SMARCA4 mutations.

[1074] In another embodiment, the present disclosure provides a method for the prevention or treatment of those tumor types that harbor SMARCA4 mutations in a warm-blooded animal, such as man, in need of such prevention or treatment, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof. Tumor types known to harbor SMARCA4 mutations include lung tumors, liver tumors, colon tumors, skin tumors, bladder tumors, cervical tumors and ovarian tumors, e.g., lung cancer, liver cancer, colon cancer, skin cancer, bladder cancer, cervical cancer and ovarian cancer.

[1075] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of lung, liver, colon, skin, bladder, cervical or ovarian cancer.

[1076] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for the treatment of lung, liver, colon, skin, bladder, cervical or ovarian cancer.

[1077] In another embodiment, the present disclosure provides a method for treating lung, liver, colon, skin, bladder, cervical or ovarian cancer in a warm-blooded animal, such as man, in need of such treatment, which comprises administering to the animal an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof.

[1078] In another embodiment where cancer is mentioned herein, the cancer is lung cancer.

[1079] In another embodiment where cancer is mentioned herein, the cancer is liver cancer.

[1080] In another embodiment where cancer is mentioned herein, the cancer is colon cancer.

[1081] In another embodiment where cancer is mentioned herein, the cancer is skin cancer.

[1082] In another embodiment where cancer is mentioned herein, the cancer is bladder cancer.

[1083] In another embodiment where cancer is mentioned herein, the cancer is cervical cancer.

[1084] In another embodiment where cancer is mentioned herein, the cancer is ovarian cancer.

[1085] In another embodiment, the present disclosure provides a Compound of the Disclosure or pharmaceutical composition thereof for use in the treatment of a SMARCA4-mutated cancer.

[1086] In another embodiment, the present disclosure provides the use of a Compound of the Disclosure or pharmaceutical composition thereof for the manufacture of a medicament for the treatment of a SMARCA4-mutated cancer.

[1087] In another embodiment, the present disclosure provides method for treating a SMARCA4- mutated cancer in a warm-blooded animal, such as man, in need of such treatment, which comprises administering an effective amount of a Compound of the Disclosure or pharmaceutical composition thereof.III. Definitions

[1088] As used herein, the term "alkyl" represents a saturated, straight or branched hydrocarbon moiety having the specified number of carbon atoms. The term "(Ci-C6)alkyl" refers to an alkyl moiety containing from 1 to 6 carbon atoms. Exemplary alkyls include, but are not limited to, methyl, ethyl, w-propyl. isopropyl, w-butyl. isobutyl, s-butyl. / -butyl, pentyl, and hexyl.

[1089] The term "alkylenyl" as used herein by itself or part of another group refers to a divalent form of an alkyl group having the specified number of carbon atoms. For example, the term "(Ci-C6)alkylenyl" refers to an alkylenyl moiety containing from 1 to 6 carbon atoms. The alkylenyl may be optionally substituted with one, two, or three substituents independently selected from halogen, cyano, and (Ci- Ce)alkoxy. Exemplary alkylenyl groups include, but are not limited to, -CH2-, -CH2CH2-, -CH2CH2CH2-, - CH2(CH2)2CH2-, and -CH2(CH2)3CH2-.

[1090] "Alkoxy" refers to a group containing an alkyl radical, defined hereinabove, attached through an oxygen linking atom. The term "(Ci-C6)alkoxy" refers to a straight- or branched-chain hydrocarbon radical having at least 1 and up to 6 carbon atoms attached through an oxygen linking atom. Exemplary "(Ci-C6)alkoxy" groups useful in the present specification include methoxy, ethoxy, w-propoxy. isopropoxy, M-butoxy, s-butoxy. isobutoxy, and / -butoxy.

[1091] The term "cycloalkylenyl" as used herein by itself or part of another group refers to a divalent form of a cycloalkyl group having the specified number of carbon atoms in the ring. For example, the term "(C3-C6)cycloalkylenyl" refers to an cycloalkylenyl moiety containing from 3 to 6 carbon atoms in the ring. The cycloalkylenyl may be optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, cyano, and (Ci-C6)alkoxy. Exemplary cycloalkylenyl groups include, but are not limited to cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexy:

[1092] The term "heterocycloalkyl" as used herein by itself or part of another group refers to group or moiety comprising a non-aromatic, monovalent, monocyclic, bicyclic, or spirocyclic radical, which issaturated or partially unsaturated, having 4- to 11-ring atoms, which includes carbon and one or two or or three heteroatoms selected independently from oxygen, sulfur, and / or nitrogen. In one embodiment, the heterocycloalkyl includes carbon and one or two heteroatoms.

[1093] The term "4- to 6-membered heterocycloalkylenyl" as used herein by itself or part of another group refers to a divalent form of a monocyclic or bicyclic heterocycloalkyl having 4, 5, or 6 ring atoms, which includes carbon and one or two heteroatoms selected independently from oxygen, sulfur, and / or nitrogen. The 4- to 6-membered heterocycloalkylenyl may be optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, cyano, or (Ci-C6)alkoxy. In one embodiment, the 4- to 6-membered heterocycloalkylenyl is a divalent form of an optionally substituted azetidine. In another embodiment, the the 4- to 6-membered heterocycloalkyleny is a divalent form of an optionally substituted piperidinyl. In another embodiment, the heterocycloalkyleny is a divalent form of an optionally substituted piperazinyl. Exemplary heterocycloalkylenyl groups include, but are not limited to:

[1094] The term "4- to 7-membered heterocycloalkylenyl" as used herein by itself or part of another group refers to a divalent form of a monocyclic or bicyclic heterocycloalkyl having 4, 5, 6, or 7 ring atoms, which includes carbon and one or two heteroatoms selected independently from oxygen, sulfur, and / or nitrogen. The 4- to 7-membered heterocycloalkylenyl may be optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, cyano, or (Ci-C6)alkoxy. In one embodiment, the 4- to 7-membered heterocycloalkylenyl is a divalent form of an optionally substituted azetidine. In another embodiment, the the 4- to 7-membered heterocycloalkyleny is a divalent form of an optionally substituted piperidinyl. In another embodiment, the heterocycloalkyleny is a divalent form of an optionally substituted piperazinyl. In another embodiment, the heterocycloalkyleny is a divalent form of an optionally substituted azepane. Exemplary heterocycloalkylenyl groups include, but are not limited to:

[1095] The term "7- to 11-membered heterocycloalkylenyl" as used herein by itself or part of another group refers to a divalent form of a bicyclic or spirocyclic heterocycloalkyl having 7, 8, 9, 10, or 11 ring atoms, which includes carbon and one, two, or three heteroatoms selected independently from oxygen,sulfur, and / or nitrogen. Exemplary 7- to 11 -membered heterocycloalkylenyl groups include, but are not limited to:

[1096] "Aryl" refers to optionally substituted monocyclic, fused bicyclic, or fused tricyclic groups having 6 to 14 carbon atoms and having at least one aromatic ring that complies with Huckel's Rule. Examples of "aryl" groups are phenyl, naphthyl, indenyl, dihydroindenyl, anthracenyl, phenanthrenyl, and the like.

[1097] "Heteroaryl" represents a group or moiety comprising an aromatic monovalent monocyclic or bicyclic radical, containing 5 to 10 ring atoms, including 1 to 4 heteroatoms independently selected from nitrogen, oxygen and sulfur. This term also encompasses bicyclic heterocyclic-aryl compounds containing an aryl ring moiety fused to a heterocycloalkyl ring moiety, containing 5 to 10 ring atoms, including 1 to 4 heteroatoms independently selected from nitrogen, oxygen and sulfur. Illustrative examples of heteroaryls useful in the present specification include, but are not limited to, furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, thiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiadiazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrazinyl, pyrimidinyl, triazinyl, benzofuranyl, isobenzofuryl, 2,3- dihydrobenzofuryl, 1,3-benzodioxolyl, dihydrobenzodioxinyl, benzothienyl, indolizinyl, indolyl, isoindolyl, dihydroindolyl, benzimidazolyl, dihydrobenzimidazolyl, benzoxazolyl, dihydrobenzoxazolyl, benzthiazolyl, benzoisothiazolyl, dihydrobenzoisothiazolyl, indazolyl, imidazopyridinyl, pyrazolopyridinyl, benzotriazolyl, triazolopyridinyl, purinyl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, quinoxalinyl, cinnolinyl, phthalazinyl, quinazolinyl, 1,5- naphthyridinyl, 1,6-naphthyridinyl, 1,7-naphthyridinyl, 1,8-naphthyridinyl, and pteridinyl. Examples of 5- membered "heteroaryl" groups include furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, thiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiadiazolyl, and isothiazolyl. Examples of 6 -membered "heteroaryl" groups include oxo-pyridyl, pyridinyl, pyridazinyl, pyrazinyl, and pyrimidinyl. Examples of 6,6-fused "heteroaryl" groups include quinolinyl, isoquinolinyl, quinoxalinyl, cinnolinyl, phthalazinyl, quinazolinyl, 1,5-naphthyridinyl, 1,6-naphthyridinyl, 1,7-naphthyridinyl, 1,8-naphthyridinyl, and pteridinyl. Examples of 6,5-fused "heteroaryl" groups include benzofuranyl, benzothienyl, benzimidazolyl, benzthiazolyl, indolizinyl, indolyl, isoindolyl, and indazolyl.

[1098] As used herein, "5- or 6-membered heteroaryl" represents a group or moiety comprising an aromatic monovalent monocyclic radical, containing 5 or 6 ring atoms, including at least one carbon atom and 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur. Selected 5 -membered heteroaryl groups contain one nitrogen, oxygen, or sulfur ring heteroatom, and optionally contain 1, 2, or 3 additional nitrogen ring atoms. Selected 6-membered heteroaryl groups contain 1, 2, or 3 nitrogen ring heteroatoms. Illustrative examples of 5- or 6-membered heteroaryl groups useful in the present specification include, but are not limited to furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrazinyl, pyrimidinyl, and triazinyl.

[1099] The terms "halogen" and "halo" represent fluoro, chloro, bromo, or iodo substituents.

[1100] "Hydroxy" as used herein by itself or as part of a group refers to the radical -OH.[HOI] The term "cyano" as used herein by itself or as part of a group refers to the radical -CN.

[1102] As used herein, the term "optionally" means that the subsequently described event(s) may or may not occur and includes both event(s) that occur and event(s) that do not occur. As such, use of the term "optionally" includes instances where the feature is present, and also instances where the feature is not present. For example, "methyl optionally substituted by one or more F" includes -CH3, -CH2F, -CHF2 and -CF3.

[1103] In present disclosure, a group such as "A-B-C" where B is defined as "a direct bond" equates to "A-C," i.e., where A and C are directly linked to each other by a covalent bond.

[1104] The term “substituted” means that one or more hydrogens on the designated atom or group is replaced by the indicated substituent(s) provided that any atom(s) bearing such substituent(s) maintains its permitted valency where the skilled person understands that the standard valencies of carbon, nitrogen and oxygen are 4, 3 and 2 respectively.

[1105] "Pharmaceutically acceptable" refers to those compounds (including salts), materials, compositions, and dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, or other problem or complication, commensurate with a reasonable benefit / risk ratio.

[1106] As used herein, the term "treatment" refers to alleviating the specified condition, eliminating or reducing one or more symptoms of the condition, slowing or eliminating the progression of the condition, and delaying the reoccurrence of the condition in a previously afflicted or diagnosed patient or subject.

[1107] The term "effective amount" means that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, system, animal, or human that is being sought, for instance, by a researcher or clinician

[1108] The term "therapeutically effective amount" means any amount which, as compared to a corresponding subject who has not received such amount, results in improved treatment, healing, or amelioration of a disease, disorder, or side effect, or a decrease in the rate of advancement of a disease ordisorder. The term also includes within its scope amounts effective to enhance normal physiological function. For use in therapy, therapeutically effective amounts of a Compound of the Disclosure may be administered as the raw chemical. Additionally, the active ingredient may be presented as a pharmaceutical composition.

[1109] Compounds of the Disclosure may have asymmetric centers and may thus give rise to enantiomers, diastereomers, and other stereoisomeric forms. The present disclosure encompasses the preparation and use of all such possible stereoisomeric forms, as well as their racemic and resolved forms, and mixtures thereof. The enantiomers and diastereomers can be separated according to methods known in the art in view of the present disclosure. When the compounds described herein contain olefinic double bonds or other centers of geometric asymmetry, and unless specified otherwise, it is intended that they include both E and Z geometric isomers. All tautomers are also encompassed by the present disclosure.

[1110] As used herein, the term "stereoisomers" is a general term for all isomers of individual molecules that differ only in the orientation of their atoms in space. It includes enantiomers, atropisomers, and isomers of compounds with more than one chiral center that are not mirror images of one another (diastereomers).[HU] The term "chiral center" or "asymmetric carbon atom" refers to a carbon atom to which four different groups are attached.[1H2] The terms "enantiomer" and "enantiomeric" refer to a molecule that cannot be superimposed on its mirror image and hence is optically active wherein the enantiomer rotates the plane of polarized light in one direction and its mirror image compound rotates the plane of polarized light in the opposite direction. Enantiomers may be separated by chiral chromatography using methods well known in the art.[1H3] The term "racemic" or "racemate" refers to a mixture of equal parts of enantiomers and which mixture is optically inactive.[1H4] The term "absolute configuration" refers to the spatial arrangement of the atoms of a chiral molecular entity (or group) and its stereochemical description, e.g., R or S.[1H5] The stereochemical terms and conventions used in the specification are meant to be consistent with those described in Pure & Appl. Chem 68:2193 (1996), unless otherwise indicated.[1H6] The term "enantiomeric excess" or "ee" refers to a measure for how much of one enantiomer is present compared to the other. For a mixture of R and S enantiomers, the percent enantiomeric excess is defined as | R - .S' | * 100, where R and S are the respective mole or weight fractions of enantiomers in a mixture such that R + S = 1. With knowledge of the optical rotation of a chiral substance, the percent enantiomeric excess is defined as ([a]Obs / [a]maX)* 100, where [a]Obs is the optical rotation of the mixture of enantiomers and [a] max is the optical rotation of the pure enantiomer. Determination of enantiomeric excess is possible using a variety of analytical techniques, including NMR spectroscopy, chiral column chromatography, or optical polarimetry. Compounds of the Disclosure that are racemic can be separated by chiral HPLC, e.g., using a CHIRALPAK IE column. In one embodiment, Compounds of the Disclosureor Intermediates of the Disclosure have an ee of about 70% or more, e.g., about 80% or more, about 90% or more, about 91% or more, about 92% or more, about 93% or more, about 94% or more, about 95% or more, about 96% or more, about 97% or more, about 98% or more, or about 99% or more.[1H7] The terms "enantiomerically pure" or "enantiopure" refer to a sample of a chiral substance all of whose molecules (within the limits of detection) have the same chirality sense.[1H8] The terms "enantiomerically enriched" or "enantioenriched" refer to a sample of a chiral substance whose enantiomeric ratio is greater than 50:50. Enantiomerically enriched compounds may be enantiomerically pure. Certain compounds of the Disclosure are enantioenriched.[1H9] The term "diastereomeric excess" or "de" refers to a measure for how much of one diastereomer is present compared to another, and is defined by analogy to enantiomeric excess. Determination of diastereomeric excess is possible using a variety of analytical techniques, including NMR spectroscopy and column chromatography.

[1120] The term "diastereoenriched enriched" refer to a sample of a chiral substance whose diastereomeric ratio is greater than 50:50. Diastereoenriched enriched compounds may be diastereomerically pure. Certain compounds of the Disclosure are diastereoenriched.[H21] The term "about," as used herein, includes the recited number ± 10%. Thus, "about 10" means 9 to 11.IV. Particular Embodiments

[1122] The present disclosure also provides the following particular embodiments.[H23] Embodiment 1. A compound having Formula (I), or pharmaceutically acceptable salt and / or stereoisomer thereof:(I), wherein:

[1124] E is:

[1125] R1is hydrogen, halogen, (Ci-C6)alkyl, (Ci-Ce)alkoxy, or;

[1126] R2is hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, or; with the provisos:

[1127] (i) when R1is hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)alkoxy, then R2is:d

[1128] (ii) when R2is hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)alkoxy, then R1is:;

[1129] R11is hydrogen or -(C1-C6)alkyl-O-P(=O)-(OH)2;

[1130] X1is CR3or N;

[1131] R3is hydrogen, halogen, or (C1-C6)alkyl;

[1132] X2is CR4or N;

[1133] R4is hydrogen, halogen, or (C1-C6)alkyl;

[1134] R5ais hydrogen, halogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (C1-C6)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (C1-C6)alkyl;

[1135] R5bis hydrogen, (C1-C6)alkyl, or (C3-C6)cycloalkyl;

[1136] R6is hydrogen, (C1-C6)alkyl, or cyano;

[1137] X3is -(CR13aR13b)n- or -O-;

[1138] n is 0 or 1

[1139] each R13aand R13bis independently H, halogen, (C1-C6)alkyl, or (C1-C6)alkoxy;

[1140] L is -G1-G2-G3-G4-, wherein G1is attached to W;

[1141] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, or cyano; 7- to 11-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;

[1142] G2is (Ci-C6)alkylenyl or a direct bond;[H43] G3is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;

[1144] G4is (Ci-C6)alkylenyl or a direct bond;

[1145] W is -C(=O)-;

[1146] R7is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1147] R8is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1148] R9is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1149] R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1150] each R12is independently halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy; and

[1151] m is 0, 1, 2, 3, or 4.[H52] Embodiment 2. A compound of Formula (IA), or pharmaceutically acceptable salt and / or stereoisomer thereof:wherein:

[1153] E is:

[1154] R1is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or

[1155] R2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or

[1156] with the provisos:

[1157] (i) when R1is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R2is:

[1158] (ii) when R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R1is:

[1159] R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;

[1160] X1is CR3orN;

[1161] R3is hydrogen, halogen, or (Ci-Ce)alkyl;

[1162] X2is CR4or N;

[1163] R4is hydrogen, halogen, or (Ci-Ce)alkyl;

[1164] R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;

[1165] R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;

[1166] R6is hydrogen, (Ci-Ce)alkyl, or cyano;

[1167] X3is -(CR13aR13b)n- or -O-;

[1168] n is O or l

[1169] each R13aand R13bis independently hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[1170] L is -G^GF-GP-G4-, wherein G1is attached to W;[H71] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[1172] G2is (Ci-Ce)alkylenyl, -C(=O)-, or a direct bond;

[1173] G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[1174] G4is (Ci-C6)alkylenyl or a direct bond;[H75] W is -C(=O)-, -CH2-, or a direct bond;

[1176] R7is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1177] R8is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1178] R9is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1179] R10is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1180] R12aand R12bare each independently hydrogen, halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen; or

[1181] R12aand R12b taken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl ; and

[1182] R12cis hydrogen or halogen.

[1183] Embodiment 3. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 1 having Formula (II):(II).

[1184] Embodiment 4. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 1 having Formula (III):

[1185] Embodiment 5. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-4, wherein X3is -(CR13aR13b)-.

[1186] Embodiment 6. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 5, wherein R13aand R13bare hydrogen.

[1187] Embodiment 7. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 5, wherein R13aand R13bare fluoro.

[1188] Embodiment 8. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 5, wherein R13ais methyl or methoxy; and R13bis hydrogen.

[1189] Embodiment 9. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-4, wherein X3is -O-.

[1190] Embodiment 10. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1 or 3-9, wherein m is 0.[H91] Embodiment 11. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1 or 3-9, wherein m is 2.

[1192] Embodiment 12. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1 or 3-9, wherein m is 1.

[1193] Embodiment 13. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 12 having Formula (IV):(IV).

[1194] Embodiment 14. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 12 having Formula (V):[H95] Embodiment 15. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 12-14, wherein each R12is fluoro, methyl, ethyl, or methoxy.

[1196] Embodiment 16. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 2, having Formula (VIII):

[1197] Embodiment 17. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 2 or 16, having Formula (IX):

[1198] Embodiment 18. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 2 or 16-17, wherein R12ais hydrogen and R12bis hydrogen, fluoro, methyl, ethyl, or methoxy.

[1199] Embodiment 19. The compound, pharmaceutically acceptable salt and / or stereoisomer thereof, according to Embodiment 2 having Formula (X):wherein:

[1200] X4is O; and

[1201] d and e are independently 1 or 2.

[1202] Embodiment 20. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 2 having Formula (XI):wherein:

[1203] X4is O; and

[1204] d and e are independently 1 or 2.

[1205] Embodiment 21. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 2 having Formula (XII):wherein:

[1206] X4is O; and

[1207] d and e are independently 1 or 2.

[1208] Embodiment 22. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-21, wherein E is E-l.

[1209] Embodiment 23. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 22, wherein R5ais hydrogen.

[1210] Embodiment 24. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 22, wherein R5ais (Ci-C6)alkyl optionally substituted with one, two, or three substituents independently selected from halogen or cyano.

[1211] Embodiment 25. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 24, wherein R5ais methyl, ethyl, isopropyl, or -CF3.

[1212] Embodiment 26. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 22, wherein R5ais (C3-C6)cycloalkyl.

[1213] Embodiment 27. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 26, wherein R5ais cyclopropyl.

[1214] Embodiment 28. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 22, wherein R5ais 4- to 6-membered heterocycloalkyl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[1215] Embodiment 29. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 22, wherein R5ais cyano.

[1216] Embodiment 30. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 22, wherein R5ais aryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[1217] Embodiment 31. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 22, wherein R5ais 5- or 6-membered heteroaryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[1218] Embodiment 32. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-21, wherein E is E-2.

[1219] Embodiment 33. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 32, wherein R5bis hydrogen.

[1220] Embodiment 34. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 32, wherein R5bis (Ci-C6)alkyl.

[1221] Embodiment 35. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 34, wherein R5bis methyl.

[1222] Embodiment 36. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 32, wherein R5bis (C3-C6)cycloalkyl.

[1223] Embodiment 37. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 36, wherein R5bis cyclopropyl or cyclobutyl.

[1224] Embodiment 38. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-37, wherein R6is hydrogen.

[1225] Embodiment 39. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-37, wherein R6is (Ci-C6)alkyl.I l l

[1226] Embodiment 40. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-37, wherein R6is cyano.

[1227] Embodiment 41. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-40, wherein:

[1228] R1is:

[1229] R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-C6)alkoxy.

[1230] Embodiment 42. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 41, wherein R2is hydrogen, halogen, or (Ci-C6)alkyl.

[1231] Embodiment 43. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 42, wherein R2is hydrogen, fluoro, or methyl.

[1232] Embodiment 44. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 41-43, wherein R11is hydrogen.

[1233] Embodiment 45. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-40, wherein:

[1234] R2is:

[1235] R1is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-C6)alkoxy.

[1236] Embodiment 46. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 45, wherein R1is hydrogen, halogen, or (Ci-C6)alkyl.

[1237] Embodiment 47. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 45, wherein R1is hydrogen, fluoro, or methyl.

[1238] Embodiment 48. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 45-47, wherein R11is hydrogen.

[1239] Embodiment 49. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-48, wherein X1is CR3.

[1240] Embodiment 50. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 49, wherein R3is hydrogen.

[1241] Embodiment 51. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 49, wherein R3is halogen.

[1242] Embodiment 52. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 51, wherein R3is fluoro.

[1243] Embodiment 53. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 49, wherein R3is (Ci-C6)alkyl.

[1244] Embodiment 54. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 53, wherein R3is methyl.

[1245] Embodiment 55. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-48, wherein X1is N.

[1246] Embodiment 56. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-55, wherein X2is CR4.

[1247] Embodiment 57. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 56, wherein R4is hydrogen.

[1248] Embodiment 58. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 56, wherein R4is halogen.

[1249] Embodiment 59. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 58, wherein R4is fluoro.

[1250] Embodiment 60. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 56, wherein R4is (Ci-C6)alkyl.

[1251] Embodiment 61. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 60, wherein R4is methyl.

[1252] Embodiment 62. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-55, wherein X2is N.

[1253] Embodiment 63. The compound of Embodiment 22, wherein E-l is:

[1255] Embodiment 65. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1 -64, wherein G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[1256] Embodiment 66. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 65, wherein:

[1257] G1is:

[1258] each R14is independently halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano;

[1259] n is 0, 1, 2, or 3; and

[1260] the bond marked with an "*" is attached to G2.

[1261] Embodiment 67. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 66, wherein n is 0.

[1262] Embodiment 68. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 66, wherein R14is fluoro, methyl, or methoxy; and n is 1, or 2.

[1263] Embodiment 69. The compound, or pharmaceutically acceptable salt thereof, according Embodiment 65, wherein G1is:

[1264] the bond marked with an "*" is attached to G2.

[1265] Embodiment 70. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-64, wherein G1is (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[1266] Embodiment 71. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-64, wherein G1is a 7- to 11 -membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano.

[1267] Embodiment 72. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 71, wherein G1is:

[1268] the bond marked with an “*” is attached to G2.

[1269] Embodiment 73. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-72, wherein G2is a direct bond.

[1270] Embodiment 74. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-72, wherein G2is (Ci-C6)alkylenyl.

[1271] Embodiment 75. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 74, wherein G2is -CEL- or -CH(CH3)-.

[1272] Embodiment 76. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 1-68, wherein G2is -C(=O)-.

[1273] Embodiment 77. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1 or 3-76, wherein G3is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano.

[1274] Embodiment 78. The compound, or pharmaceutically acceptable salt thereof, according Embodiment 77, wherein G3is:

[1275] the bond marked with an "*" is attached to G4.

[1276] Embodiment 79. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 2-9 or 18-76, wherein G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano.

[1277] Embodiment 80. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 79, wherein G3is:

[1278] the bond marked with an “*” is attached to G4.

[1279] Embodiment 81. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-76, wherein G3is 7- to 11 -membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[1280] Embodiment 82. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 81, wherein G3is:

[1281] the bond marked with an "*" is attached to G4.

[1282] Embodiment 83. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 81, wherein:

[1283] G3is:

[1284] each R15is independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano;

[1285] u is 0, 1, 2, or 3;

[1286] v, w, x, and t are independently 1, 2, or 3; and

[1287] the bond marked with an "*" is attached to G4.

[1288] Embodiment 84. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 83, wherein v, w, x, and y are independently 1 or 2.

[1289] Embodiment 85. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 84, wherein G3is:

[1290] the bond marked with an "*" is attached to G4.

[1291] Embodiment 86. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-76, wherein G3is (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

[1292] Embodiment 87. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-86, wherein G4is (Ci-C6)alkylenyl.

[1293] Embodiment 88. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-86, wherein G4is a direct bond.

[1294] Embodiment 89. The compound, or pharmaceutically acceptable salt thereof, of any one of Embodiments 1-64, wherein L is:

[1295] the bond marked with an "*" is attached to E.

[1296] Embodiment 90. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-89, wherein R7is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[1297] Embodiment 91. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 90, wherein R7is halogen or (Ci-C6)alkyl.

[1298] Embodiment 92. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 91, wherein R7is fluoro or methyl.

[1299] Embodiment 93. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 90-92, wherein R8, R9, and R10are hydrogen.

[1300] Embodiment 94. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-89, wherein R8is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[1301] Embodiment 95. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 94, wherein R8is halogen or (Ci-C6)alkyl.

[1302] Embodiment 96. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 95, wherein R8is fluoro or methyl.

[1303] Embodiment 97. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 94-96, wherein R7, R9, and R10are hydrogen.

[1304] Embodiment 98. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-89, wherein R9is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[1305] Embodiment 99. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 98, wherein R9is halogen.

[1306] Embodiment 100. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 99, wherein R9is fluoro.

[1307] Embodiment 101. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 98-100, wherein R7, R8, and R10are hydrogen.

[1308] Embodiment 102. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-89, wherein R10is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

[1309] Embodiment 103. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 102, wherein R10is halogen.

[1310] Embodiment 104. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 103, wherein R10is fluoro.

[1311] Embodiment 105. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 102-104, wherein R7, R8, and R9are hydrogen.

[1312] Embodiment 106. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-89, wherein R7, R8, R9, and R10are hydrogen.

[1313] Embodiment 107. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1, 5-9, 63, or 64, having Formula (VI):(VI), wherein:

[1314] R15ais fluoro;

[1315] p is 0, 1, or 2;

[1316] Z1is CR15bor N;

[1317] R15bis hydrogen, fluoro, methyl, or methoxy;

[1318] R16is hydrogen or methyl;

[1319] Z2is CH or N;

[1320] R17is fluoro or methyl;

[1321] q is 0, 1, or 2;

[1322] R12is fluoro, methyl, ethyl, or methoxy; and m is 1; or R12is hydrogen; and m is 0;

[1323] R7, R8, R9, and R10are independently hydrogen, fluoro, chloro, methyl, -CF3, cyclopropyl, methoxy, or cyano.

[1324] Embodiment 108. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1, 5-9, 63, or 64, having Formula (VII):wherein:

[1325] R15ais fluoro;

[1326] p is 0, 1, or 2;

[1327] Z1is CR15bor N;

[1328] R15bis hydrogen, fluoro, methyl, or methoxy;

[1329] R16is hydrogen or methyl;

[1330] Z2is CH or N;

[1331] R17is fluoro or methyl;

[1332] q is 0, 1, or 2;

[1333] R12is fluoro, methyl, ethyl, or methoxy; and m is 1; or R12is hydrogen; and m is 0;

[1334] R7, R8, R9, and R10are independently hydrogen, fluoro, chloro, methyl, -CF3, cyclopropyl, methoxy, or cyano.

[1335] Embodiment 109. The compound, pharmaceutically acceptable salt and / or stereoisomer thereof, according to Embodiment 2, having Formula (XIII):(XIII), wherein:

[1336] R7, R8, R9, and R10are independently hydrogen or methyl;

[1337] R12aand R12bare independently hydrogen or methyl;

[1338] R15ais fluoro;

[1339] p is 0, 1, or 2;

[1340] Z1is CR15borN;

[1341] R15bis hydrogen or fluoro;

[1342] Z2is CH or N;

[1343] R17is fluoro; and

[1344] q is 0, 1, or 2.

[1345] Embodiment 110. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 2, having Formula (XIV):(XIV), wherein:

[1346] R7, R8, R9, and R10are independently hydrogen or methyl;

[1347] R12aand R12bare independently hydrogen or methyl;

[1348] R15ais fluoro;

[1349] p is 0, 1, or 2;

[1350] Z1is CR15borN;

[1351] R15bis hydrogen or fluoro;

[1352] Z2is CH or N;

[1353] R17is fluoro; and

[1354] q is 0, 1, or 2.

[1355] Embodiment 111. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 1 selected from any one or more of the compounds of Compound List 1, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.

[1356] Embodiment 112. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 1 selected from any one or more of the compounds of Compound List 2 and / or List 3, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.

[1357] Embodiment 113. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 2 selected from any one or more of the compounds of Compound List 4, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.

[1358] Embodiment 114. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 111, wherein the compound is:

[1359] Embodiment 115. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 111, wherein the compound is:

[1360] Embodiment 116. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 113, wherein the compound is:

[1361] Embodiment 117. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 113, wherein the compound is:

[1362] Embodiment 118. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 113, wherein the compound is:

[1363] Embodiment 119. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 113, wherein the compound is:

[1364] Embodiment 120. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 113, wherein the compound is:

[1365] Embodiment 121. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment 113, wherein the compound is:

[1366] Embodiment 122. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 113, wherein the compound is:

[1367] Embodiment 123. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment 113, wherein the compound is:

[1368] Embodiment 124. A pharmaceutical composition comprising the compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, and a pharmaceutically acceptable excipient.

[1369] Embodiment 125. A method of degrading SMARCA2 protein in a human, comprising administering to a human in need thereof an effective amount of the compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124.

[1370] Embodiment 126. A method of reducing the level of SMARCA2 activity in a human, comprising administering to a human in need thereof an effective amount of the compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124.

[1371] Embodiment 127. A method of treating cancer in a human, comprising administering to a human in need thereof an effective amount of the compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124.

[1372] Embodiment 128. The method of Embodiment 127, wherein the cancer is a SMARCA2- sensitive cancer.

[1373] Embodiment 129. The method of Embodiment 127, wherein the cancer is a SMARCA2- mutated cancer.

[1374] Embodiment 130. The method of any one of Embodiments 127-129, wherein the cancer is a solid tumor.

[1375] Embodiment 131. The method of any one of Embodiments 127-129, wherein the cancer is lung, liver, colon, skin, bladder, cervical or ovarian cancer.

[1376] Embodiment 132. A compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124 for use in degrading SMARCA2 protein in a human.

[1377] Embodiment 133. A compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124 for use in reducing the level of SMARCA2 activity in a human.

[1378] Embodiment 134. A compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124 for use in treating cancer in a human.

[1379] Embodiment 135. The compound for use of Embodiment 134, wherein the cancer is aSMARCA2-sensitive cancer.

[1380] Embodiment 136. The compound for use of Embodiment 134, wherein the cancer is aSMARCA2 -mutated cancer.

[1381] Embodiment 137. The compound for use of any one of Embodiments 134-136, wherein the cancer is a solid tumor.

[1382] Embodiment 138. The compound for use of any one of Embodiments 134-136, wherein the cancer is lung, liver, colon, skin, bladder, cervical or ovarian cancer.

[1383] Embodiment 139. Use of a compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124 in the manufacture of a medicament for degrading SMARCA2 protein in a human.

[1384] Embodiment 140. Use of a compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124 in the manufacture of a medicament for reducing the level of SMARCA2 activity in a human.

[1385] Embodiment 141. Use of a compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments 1-123, or the composition of Embodiment 124 in the manufacture of a medicament for treating cancer in a human.

[1386] Embodiment 142. The compound, or pharmaceutical acceptable salt thereof, for use of Embodiment 141, wherein the cancer is a SMARCA2-sensitive cancer.

[1387] Embodiment 143. The compound, or pharmaceutically acceptable salt thereof, for use of Embodiment 141, wherein the cancer is a SMARCA2 -mutated cancer.

[1388] Embodiment 144. The compound for use of any one of Embodiments 141-143, wherein the cancer is a solid tumor.

[1389] Embodiment 145. The compound for use of any one of Embodiments 141-143, wherein the cancer is lung, liver, colon, skin, bladder, cervical or ovarian cancer.

[1390] The present disclosure also provides the following particular embodiments.

[1391] Embodiment A 1. A compound having Formula (A), or pharmaceutically acceptable salt and / or stereoisomer thereof:), wherein:

[1392] E is:;

[1393] R1is hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, or;

[1394] R2is hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, or;

[1395] with the provisos:

[1396] (i) when R1is hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)alkoxy, then R2is:d

[1397] (ii) when R2is hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)alkoxy, then R1is:;

[1398] R11is hydrogen or -(C1-C6)alkyl-O-P(=O)-(OH)2;

[1399] X1is CR3or N;

[1400] R3is hydrogen, halogen, or (C1-C6)alkyl;

[1401] X2is CR4or N;

[1402] R4is hydrogen, halogen, or (Ci-C6)alkyl;

[1403] R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;

[1404] R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;

[1405] R6is hydrogen, (Ci-Ce)alkyl, or cyano;

[1406] X3is -(CR13aR13b)n- or -O-;

[1407] n is 0 or 1

[1408] each R13aand R13bis independently hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[1409] L is -G^GF-G -G4-, wherein G1is attached to W;

[1410] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[1411] G2is (Ci-C6)alkylenyl, -C(=O)-, or a direct bond;

[1412] G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[1413] G4is (Ci-C6)alkylenyl or a direct bond;

[1414] W is -C(=O)-, -CH2-, or a direct bond;

[1415] R7is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1416] R8is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1417] R9is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1418] R10is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;

[1419] each R12is independently halogen, (Ci-C6)alkyl, or (Ci-C6)alkoxy;

[1420] m is 0, 1, 2, 3, or 4;

[1421] R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen; or

[1422] R12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (Cs-C7)cycloalkyl;

[1423] R12cis hydrogen or halogen;

[1424] Rais hydrogen or halogen; and

[1425] Rbis hydrogen or halogen.

[1426] Embodiment A 2. A compound having Formula (I), or pharmaceutically acceptable salt and / or stereoisomer thereof:(I), wherein:

[1427] E is:

[1428] R1is hydrogen, halogen, (Ci-C6)alkyl, (Ci-Ce)alkoxy, or

[1429] R2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or

[1430] with the provisos:

[1431] (i) when R1is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R2is:

[1432] (ii) when R2is hydrogen, halogen, (Ci-C6)alkyl, or (Ci-Ce)alkoxy, then R1is:

[1433] R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;

[1434] X1is CR3orN;

[1435] R3is hydrogen, halogen, or (Ci-Ce)alkyl;

[1436] X2is CR4or N;

[1437] R4is hydrogen, halogen, or (Ci-Ce)alkyl;

[1438] R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;

[1439] R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;

[1440] R6is hydrogen, (Ci-Ce)alkyl, or cyano;

[1441] X3is -(CR13aR13b)n- or -O-;

[1442] n is 0 or 1

[1443] each R13aand R13bis independently H, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[1444] L is -G^GF-G -G4-, wherein G1is attached to W;

[1445] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[1446] G2is (Ci-C6)alkylenyl or a direct bond;

[1447] G3is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionallysubstituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;

[1448] G4is (Ci-C6)alkylenyl or a direct bond;

[1449] W is -C(=O)-;

[1450] R7is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1451] R8is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1452] R9is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1453] R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1454] each R12is independently halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy; and

[1455] m is 0, 1, 2, 3, or 4.

[1456] Embodiment A 3. A compound having Formula (IA), or pharmaceutically acceptable salt and / or stereoisomer thereof:wherein:

[1457] E is:

[1458] R1is hydrogen, halogen, (Ci-C6)alkyl, (Ci-Ce)alkoxy, or

[1459] R2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or

[1460] with the provisos:

[1461] (i) when R1is hydrogen, halogen, (Ci-C6)alkyl, or (Ci-Ce)alkoxy, then R2is:

[1462] (ii) when R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R1is:

[1463] R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;

[1464] X1is CR3orN;

[1465] R3is hydrogen, halogen, or (Ci-Ce)alkyl;

[1466] X2is CR4or N;

[1467] R4is hydrogen, halogen, or (Ci-Ce)alkyl;

[1468] R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;

[1469] R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;

[1470] R6is hydrogen, (Ci-Ce)alkyl, or cyano;

[1471] X3is -(CR13aR13b)n- or -O-;

[1472] n is 0 or 1

[1473] each R13aand R13bis independently hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;

[1474] L is -G^GF-G -G4-, wherein G1is attached to W;

[1475] G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;

[1476] G2is (Ci-C6)alkylenyl, -C(=O)-, or a direct bond;

[1477] G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;

[1478] G4is (Ci-C6)alkylenyl or a direct bond;

[1479] W is -C(=O)-, -CH2-, or a direct bond;

[1480] R7is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1481] R8is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1482] R9is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1483] R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;

[1484] R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen; or

[1485] R12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl ; and

[1486] R12cis hydrogen or halogen.

[1487] Embodiment A 4. The compound, or pharmaceutically acceptable salt thereof, according to Embodiments A 1 or 2 having Formula (II):(II).

[1488] Embodiment A 5. The compound, or pharmaceutically acceptable salt thereof, according to Embodiments A 1 or 2 having Formula (III):

[1489] Embodiment A 6. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-5, wherein X3is -(CR13aR13b)-.

[1490] Embodiment A 7. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 6, wherein R13aand R13bare hydrogen.

[1491] Embodiment A 8. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 6, wherein R13aand R13bare fluoro.

[1492] Embodiment A 9. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 6, wherein R13ais methyl or methoxy; and R13bis hydrogen.

[1493] Embodiment A 10. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-5, wherein X3is -O-.

[1494] Embodiment A l l. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1, 2, or 4-10, wherein m is 0.

[1495] Embodiment A 12. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1, 2, or 4-10, wherein m is 2.

[1496] Embodiment A 13. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1, 2, or 4-10, wherein m is 1.

[1497] Embodiment A 14. The compound, or pharmaceutically acceptable salt thereof, according to

[1498] Embodiment A 15. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 2 having Formula (V):

[1499] Embodiment A 16. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 13-15, wherein each R12is fluoro, methyl, ethyl, or methoxy.

[1500] Embodiment A 17. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 3, having Formula (VIII):

[1501] Embodiment A 18. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 3 or 17, having Formula (IX):

[1502] Embodiment A 19. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 3, 17, or 18, wherein R12ais hydrogen and R12bis hydrogen, fluoro, methyl, ethyl, or methoxy.

[1503] Embodiment A 20. The compound, pharmaceutically acceptable salt and / or stereoisomer thereof, according to Embodiment A 3 having Formula (X):wherein:

[1504] X4is O; and

[1505] d and e are independently 1 or 2.

[1506] Embodiment A 21. The compound, or pharmaceutically acceptable salt thereof, according toEmbodiment A 3 having Formula (XI):wherein:

[1507] X4is O; and

[1508] d and e are independently 1 or 2.

[1509] Embodiment A 22. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 3 having Formula (XII):wherein:

[1510] X4is O; and

[1511] d and e are independently 1 or 2.

[1512] Embodiment A 23. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-22, wherein E is E-l.

[1513] Embodiment A 24. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 23, wherein R5ais hydrogen.

[1514] Embodiment A 25. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 23, wherein R5ais (Ci-Ce)alkyl optionally substituted with one, two, or three substituents independently selected from halogen or cyano.

[1515] Embodiment A 26. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 25, wherein R5ais methyl, ethyl, isopropyl, or -CF3.

[1516] Embodiment A 27. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 23, wherein R5ais (C3-C6)cycloalkyl.

[1517] Embodiment A 28. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 27, wherein R5ais cyclopropyl.

[1518] Embodiment A 29. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 23, wherein R5ais 4- to 6-membered heterocycloalkyl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[1519] Embodiment A 30. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 23, wherein R5ais cyano.

[1520] Embodiment A 31. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 23, wherein R5ais aryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[1521] Embodiment A 32. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 23, wherein R5ais 5- or 6-membered heteroaryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

[1522] Embodiment A 33. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-22, wherein E is E-2.

[1523] Embodiment A 34. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 33, wherein R5bis hydrogen.

[1524] Embodiment A 35. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 33, wherein R5bis (Ci-C6)alkyl.

[1525] Embodiment A 36. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 35, wherein R5bis methyl.

[1526] Embodiment A 37. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 33, wherein R5bis (C3-C6)cycloalkyl.

[1527] Embodiment A 38. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 37, wherein R5bis cyclopropyl or cyclobutyl.

[1528] Embodiment A 39. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-38, wherein R6is hydrogen.

[1529] Embodiment A 40. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-38, wherein R6is (Ci-C6)alkyl.

[1530] Embodiment A 41. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-38, wherein R6is cyano.

[1531] Embodiment A 42. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-41, wherein:

[1532] R1is:

[1533] R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-C6)alkoxy.

[1534] Embodiment A 43. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 42, wherein R2is hydrogen, halogen, or (Ci-C6)alkyl.

[1535] Embodiment A 44. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 43, wherein R2is hydrogen, fluoro, or methyl.

[1536] Embodiment A 45. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 42-44, wherein R11is hydrogen.

[1537] Embodiment A 46. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-41, wherein:

[1538] R2is:

[1539] R1is hydrogen, halogen, (Ci-C6)alkyl, or (Ci-C6)alkoxy.

[1540]

[1541] Embodiment A 47. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 46, wherein R1is hydrogen, halogen, or (Ci-C6)alkyl.

[1542] Embodiment A 48. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 46, wherein R1is hydrogen, fluoro, or methyl.

[1543] Embodiment A 49. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 46-48, wherein R11is hydrogen.

[1544] Embodiment A 50. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-49, wherein X1is CR3.

[1545] Embodiment A 51. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 50, wherein R3is hydrogen.

[1546] Embodiment A 52. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 50, wherein R3is halogen.

[1547] Embodiment A 53. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 52, wherein R3is fluoro.

[1548] Embodiment A 54. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 50, wherein R3is (Ci-C6)alkyl.

[1549] Embodiment A 55. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 54, wherein R3is methyl.

[1550] Embodiment A 56. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-49, wherein X1is N.

[1551] Embodiment A 57. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-56, wherein X2is CR4.

[1552] Embodiment A 58. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 57, wherein R4is hydrogen.

[1553] Embodiment A 59. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 57, wherein R4is halogen.

[1554] Embodiment A 60. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 59, wherein R4is fluoro.

[1555] Embodiment A 61. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 57, wherein R4is (Ci-C6)alkyl.

[1556] Embodiment A 62. The compound, or pharmaceutically acceptable salt thereof, according to Embodiment A 61, wherein R4is methyl.

[1557] Embodiment A 63. The compound, or pharmaceutically acceptable salt thereof, according to any one of Embodiments A 1-56, wherein X2is N.

[1558] Embodiment A 64. The compound of Embodiment A 23, wherein E-l is:

[1559] Embodiment A 65. The compound of Embodiment A 33,...

Claims

WHAT IS CLAIMED IS:

1. A compound having Formula (A), or pharmaceutically acceptable salt and / or stereoisomer thereof:(A), wherein: E is:; R1is hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, or; R2is hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, or; with the provisos: (i) when R1is hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)alkoxy, then R2is:d (ii) when R2is hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)alkoxy, then R1is:; R11is hydrogen or -(C1-C6)alkyl-O-P(=O)-(OH)2;X1is CR3or N;R3is hydrogen, halogen, or (Ci-C6)alkyl;X2is CR4or N;R4is hydrogen, halogen, or (Ci-Ce)alkyl;R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;R6is hydrogen, (Ci-Ce)alkyl, or cyano;X3is -(CR13aR13b)n- or -O-; n is 0 or 1 each R13aand R13bis independently hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;L is -G^GP-G -G4-, wherein G1is attached to W;G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;G2is (Ci-C6)alkylenyl, -C(=O)-, or a direct bond;G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;G4is (Ci-C6)alkylenyl or a direct bond;W is -C(=O)-, -CH2-, or a direct bond;R7is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;R8is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;R9is hydrogen, halogen, (Ci-C6)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-C6)alkyl is optionally substituted with one, two, or three halogen;R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen; each R12is independently halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy; m is 0, 1, 2, 3, or 4;R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci- Ce)alkyl is optionally substituted with one, two, or three halogen; orR12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl;R12cis hydrogen or halogen;Rais hydrogen or halogen; andRbis hydrogen or halogen.

2. A compound having Formula (I), or pharmaceutically acceptable salt and / or stereoisomer thereof:(I), wherein:E is:R1is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, orR2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, orwith the provisos:(i) when R1is hydrogen, halogen, (Ci-C6)alkyl, or (Ci-Ce)alkoxy, then R2is:(ii) when R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R1is:R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;X1is CR3or N;R3is hydrogen, halogen, or (Ci-Ce)alkyl;X2is CR4or N;R4is hydrogen, halogen, or (Ci-Ce)alkyl;R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;R6is hydrogen, (Ci-Ce)alkyl, or cyano;X3is -(CR13aR13b)n- or -O-; n is 0 or 1 each R13aand R13bis independently H, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;L is -G^GP-G -G4-, wherein G1is attached to W;G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;G2is (Ci-C6)alkylenyl or a direct bond;G3is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionallysubstituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;G4is (Ci-C6)alkylenyl or a direct bond;W is -C(=O)-;R7is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;R8is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;R9is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen; each R12is independently halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy; and m is 0, 1, 2, 3, or 4.

3. A compound having Formula (IA), or pharmaceutically acceptable salt and / or stereoisomer thereof:wherein:E is:R1is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, orR2is hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, orwith the provisos:(i) when R1is hydrogen, halogen, (Ci-C6)alkyl, or (Ci-Ce)alkoxy, then R2is:(ii) when R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy, then R1is:R11is hydrogen or -(Ci-C6)alkyl-O-P(=O)-(OH)2;X1is CR3or N;R3is hydrogen, halogen, or (Ci-Ce)alkyl;X2is CR4or N;R4is hydrogen, halogen, or (Ci-Ce)alkyl;R5ais hydrogen, halogen, (Ci-Ce)alkyl, (C3-C6)cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three substituents independently selected from halogen or cyano; and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-Ce)alkyl;R5bis hydrogen, (Ci-Ce)alkyl, or (C3-C6)cycloalkyl;R6is hydrogen, (Ci-Ce)alkyl, or cyano;X3is -(CR13aR13b)n- or -0-; n is 0 or 1 each R13aand R13bis independently hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-Ce)alkoxy;L is -G^GP-G -G4-, wherein G1is attached to W;G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci-C6)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-C6)alkyl, (Ci- Ce)alkoxy, or cyano;G2is (Ci-C6)alkylenyl, -C(=0)-, or a direct bond;G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; 7- to 11- membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; or (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci- Ce)alkoxy, or cyano;G4is (Ci-C6)alkylenyl or a direct bond;W is -C(=O)-, -CH2-, or a direct bond;R7is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;R8is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;R9is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;R10is hydrogen, halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen;R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci- Ce)alkyl is optionally substituted with one, two, or three halogen; orR12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl ; andR12cis hydrogen or halogen.

4. The compound, or pharmaceutically acceptable salt thereof, according to claims 1 or 2 havingFormula (II):

5. The compound, or pharmaceutically acceptable salt thereof, according to claims 1 or 2 having Formula (III):

6. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-5, wherein X3is -(CR13aR13b)-.

7. The compound, or pharmaceutically acceptable salt thereof, according to claim 6, wherein R13aand R13bare hydrogen.

8. The compound, or pharmaceutically acceptable salt thereof, according to claim 6, wherein R13aand R13bare fluoro.

9. The compound, or pharmaceutically acceptable salt thereof, according to claim 6, wherein R13ais methyl or methoxy; and R13bis hydrogen.

10. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-5, wherein X3is -O-.

11. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 2, or 4-10, wherein m is 0.

12. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 2, or 4-10, wherein m is 2.

13. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 2, or 4-10, wherein m is 1.

14. The compound, or pharmaceutically acceptable salt thereof, according to claim 2 having Formula (IV):(IV).The compound, or pharmaceutically acceptable salt thereof, according to claim 2 havingFormula (V):

16. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 13-15, wherein each R12is fluoro, methyl, ethyl, or methoxy.

17. The compound, or pharmaceutically acceptable salt thereof, according to claim 3, having Formula (VIII):

18. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 3 or 17, having Formula (IX):

19. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 3, 17, or 18, wherein R12ais hydrogen and R12bis hydrogen, fluoro, methyl, ethyl, or methoxy.

20. The compound, pharmaceutically acceptable salt and / or stereoisomer thereof, according to claim 3 having Formula (X):wherein:X4is O; and d and e are independently 1 or 2.

21. The compound, or pharmaceutically acceptable salt thereof, according to claim 3 having Formula (XI):wherein:X4is O; and d and e are independently 1 or 2.

22. The compound, or pharmaceutically acceptable salt thereof, according to claim 3 having Formula (XII):wherein:X4is O; and d and e are independently 1 or 2.

23. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1 -22, wherein E is E-l.

24. The compound, or pharmaceutically acceptable salt thereof, according to claim 23, wherein R5ais hydrogen.

25. The compound, or pharmaceutically acceptable salt thereof, according to claim 23, wherein R5ais (Ci-Ce)alkyl optionally substituted with one, two, or three substituents independently selected from halogen or cyano.

26. The compound, or pharmaceutically acceptable salt thereof, according to claim 25, wherein R5ais methyl, ethyl, isopropyl, or -CF3.

27. The compound, or pharmaceutically acceptable salt thereof, according to claim 23, wherein R5ais (C3-C6)cycloalkyl.

28. The compound, or pharmaceutically acceptable salt thereof, according to claim 27, wherein R5ais cyclopropyl.

29. The compound, or pharmaceutically acceptable salt thereof, according to claim 23, wherein R5ais4- to 6-membered heterocycloalkyl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

30. The compound, or pharmaceutically acceptable salt thereof, according to claim 23, wherein R5ais cyano.

31. The compound, or pharmaceutically acceptable salt thereof, according to claim 23, wherein R5ais aryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

32. The compound, or pharmaceutically acceptable salt thereof, according to claim 23, wherein R5ais5- or 6-membered heteroaryl optionally substituted with one, two, or three substituents independently selected from halogen, cyano, or (Ci-C6)alkyl.

33. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-22, wherein E is E-2.

34. The compound, or pharmaceutically acceptable salt thereof, according to claim 33, wherein R5bis hydrogen.

35. The compound, or pharmaceutically acceptable salt thereof, according to claim 33, wherein R5bis (Ci-C6)alkyl.

36. The compound, or pharmaceutically acceptable salt thereof, according to claim 35, wherein R5bis methyl.

37. The compound, or pharmaceutically acceptable salt thereof, according to claim 33, wherein R5bis (C3-C6)cycloalkyl.

38. The compound, or pharmaceutically acceptable salt thereof, according to claim 37, wherein R5bis cyclopropyl or cyclobutyl.

39. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-38, wherein R6is hydrogen.

40. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-38, wherein R6is (Ci-C6)alkyl.

41. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-38, wherein R6is cyano.

42. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-41, wherein:R1is:R2is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-C6)alkoxy.

43. The compound, or pharmaceutically acceptable salt thereof, according to claim 42, wherein R2is hydrogen, halogen, or (Ci-C6)alkyl.

44. The compound, or pharmaceutically acceptable salt thereof, according to claim 43, wherein R2is hydrogen, fluoro, or methyl.

45. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 42-44, wherein R11is hydrogen.

46. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-41, wherein:R2is:R1is hydrogen, halogen, (Ci-Ce)alkyl, or (Ci-C6)alkoxy.

47. The compound, or pharmaceutically acceptable salt thereof, according to claim 46, wherein R1is hydrogen, halogen, or (Ci-C6)alkyl.

48. The compound, or pharmaceutically acceptable salt thereof, according to claim 46, wherein R1is hydrogen, fluoro, or methyl.

49. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 46-48, wherein R11is hydrogen.

50. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-49, wherein X1is CR3.

51. The compound, or pharmaceutically acceptable salt thereof, according to claim 50, wherein R3is hydrogen.

52. The compound, or pharmaceutically acceptable salt thereof, according to claim 50, wherein R3is halogen.

53. The compound, or pharmaceutically acceptable salt thereof, according to claim 52, wherein R3is fluoro.

54. The compound, or pharmaceutically acceptable salt thereof, according to claim 50, wherein R3is (Ci-C6)alkyl.

55. The compound, or pharmaceutically acceptable salt thereof, according to claim 54, wherein R3is methyl.

56. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-49, wherein X1is N.

57. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-56, wherein X2is CR4.

58. The compound, or pharmaceutically acceptable salt thereof, according to claim 57, wherein R4is hydrogen.

59. The compound, or pharmaceutically acceptable salt thereof, according to claim 57, wherein R4is halogen.

60. The compound, or pharmaceutically acceptable salt thereof, according to claim 59, wherein R4is fluoro.

61. The compound, or pharmaceutically acceptable salt thereof, according to claim 57, wherein R4is (Ci-C6)alkyl.

62. The compound, or pharmaceutically acceptable salt thereof, according to claim 61, wherein R4is methyl.

63. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-56, wherein X2is N.

64. The compound of claim 23, wherein E-l is:

66. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-65, wherein G1is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

67. The compound, or pharmaceutically acceptable salt thereof, according to claim 66, wherein:G1is:each R14is independently halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; n is 0, 1, 2, or 3; and the bond marked with an "*" is attached to G2.

68. The compound, or pharmaceutically acceptable salt thereof, according to claim 67, wherein n is 0.

69. The compound, or pharmaceutically acceptable salt thereof, according to claim 67, wherein R14is fluoro, methyl, or methoxy; and n is 1, or 2.

70. The compound, or pharmaceutically acceptable salt thereof, according claim 66, wherein G1is: the bond m71. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-65, wherein G1is (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

72. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-65, wherein G1is a 7- to 11 -membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

73. The compound, or pharmaceutically acceptable salt thereof, according to claim 72, wherein G1is:the bond marked with an “*” is attached to G2.

74. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-73, wherein G2is a direct bond.

75. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-73, wherein G2is (Ci-C6)alkylenyl.

76. The compound, or pharmaceutically acceptable salt thereof, according to claim 75, wherein G2is - CH2- or -CH(CH3)-.

77. The compound, or pharmaceutically acceptable salt thereof, according to claim 1-73, wherein G2is -C(=O)-.

78. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-73, wherein G3is 4- to 6-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

79. The compound, or pharmaceutically acceptable salt thereof, according claim 78, wherein G3is:the bond marked with an "*" is attached to G4.

80. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-77, wherein G3is 4- to 7-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

81. The compound, or pharmaceutically acceptable salt thereof, according to claim 80, wherein G3is:the bond marked with an “*” is attached to G4.

82. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-77, wherein G3is 7- to 11-membered heterocycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

83. The compound, or pharmaceutically acceptable salt thereof, according to claim 82, wherein G3is:the bond marked with an "*" is attached to G4.

84. The compound, or pharmaceutically acceptable salt thereof, according to claim 82, wherein:each R15is independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano; u is 0, 1, 2, or 3; v, w, x, and t are independently 1, 2, or 3; and the bond marked with an "*" is attached to G4.

85. The compound, or pharmaceutically acceptable salt thereof, according to claim 84, wherein v, w, x, and y are independently 1 or 2.

86. The compound, or pharmaceutically acceptable salt thereof, according to claim 85, wherein G3is:the bond marked with an "*" is attached to G4.

87. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-77, wherein G3is (C3-C6)cycloalkylenyl optionally substituted with one, two, or three substituents independently selected from halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, or cyano.

88. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-87, wherein G4is (Ci-C6)alkylenyl.

89. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-87, wherein G4is a direct bond.

90. The compound, or pharmaceutically acceptable salt thereof, of any one of claims 1-65, wherein L is:the bond marked with an "*" is attached to E.

91. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1 -90, wherein R7is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

92. The compound, or pharmaceutically acceptable salt thereof, according to claim 91, wherein R7is halogen or (Ci-C6)alkyl.

93. The compound, or pharmaceutically acceptable salt thereof, according to claim 92, wherein R7is fluoro or methyl.

94. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 91-93, wherein R8, R9, and R10are hydrogen.

95. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1 -90, wherein R8is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

96. The compound, or pharmaceutically acceptable salt thereof, according to claim 95, wherein R8is halogen or (Ci-C6)alkyl.

97. The compound, or pharmaceutically acceptable salt thereof, according to claim 96, wherein R8is fluoro or methyl.

98. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 95-97, wherein R7, R9, and R10are hydrogen.

99. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-90, wherein R9is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

100. The compound, or pharmaceutically acceptable salt thereof, according to claim 99, wherein R9is halogen.

101. The compound, or pharmaceutically acceptable salt thereof, according to claim 100, wherein R9is fluoro.

102. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 99-101, wherein R7, R8, and R10are hydrogen.

103. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-90, wherein R10is halogen, (Ci-Ce)alkyl, cyano, or (C3-C6)cycloalkyl, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen.

104. The compound, or pharmaceutically acceptable salt thereof, according to claim 103, wherein R10is halogen.

105. The compound, or pharmaceutically acceptable salt thereof, according to claim 104, wherein R10is fluoro.

106. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 103-105, wherein R7, R8, and R9are hydrogen.

107. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-90, wherein R7, R8, R9, and R10are hydrogen.

108. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 6-13, or 23-107, wherein R12aand R12bare each independently hydrogen, halogen, (Ci-Ce)alkyl, (Ci-Ce)alkoxy, wherein (Ci-Ce)alkyl is optionally substituted with one, two, or three halogen; and m is 0.

109. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 6-13, or 23-107, wherein R12aand R12btaken together with the carbon atoms to which they are attached form an optionally substituted 5- to 7-membered heterocycloalkyl or an optionally substituted (C5-C7)cycloalkyl; and m is 0.

110. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 6-13, or 23-109, wherein Rais fluoro and Rbis hydrogen.

111. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 6-13, or 23-110, wherein Rais hydrogen and Rbis fluoro.

112. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 2, 6-10,(VI), wherein:R15ais fluoro; p is 0, 1, or 2;Z1is CR15bor N;R15bis hydrogen, fluoro, methyl, or methoxy;R16is hydrogen or methyl;Z2is CH or N;R17is fluoro or methyl; q is 0, 1, or 2;R12is fluoro, methyl, ethyl, or methoxy; and m is 1; or R12is hydrogen; and m is 0;R7, R8, R9, and R10are independently hydrogen, fluoro, chloro, methyl, -CF3, cyclopropyl, methoxy, or cyano.

113. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 2, 6-10,64, or 65, having Formula (VII):wherein:R15ais fluoro;p is 0, 1, or 2;Z1is CR15bor N;R15bis hydrogen, fluoro, methyl, or methoxy;R16is hydrogen or methyl;Z2is CH or N;R17is fluoro or methyl; q is 0, 1, or 2;R12is fluoro, methyl, ethyl, or methoxy; and m is 1; or R12is hydrogen; and m is 0;R7, R8, R9, and R10are independently hydrogen, fluoro, chloro, methyl, -CF3, cyclopropyl, methoxy, or cyano.

114. The compound, pharmaceutically acceptable salt and / or stereoisomer thereof, according to any one of claims 3, 64, or 65 having Formula (XIII):(XIII), wherein:R7, R8, R9, and R10are independently hydrogen or methyl;R12aand R12bare independently hydrogen or methyl;R15ais fluoro; p is 0, 1, or 2;Z1is CR15bor N;R15bis hydrogen or fluoro;Z2is CH or N;R17is fluoro; and q is 0, 1, or 2.

115. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 3, 64, or 65, having Formula (XIV):(XIV),wherein:R7, R8, R9, and R10are independently hydrogen or methyl;R12aand R12bare independently hydrogen or methyl;R15ais fluoro; p is 0, 1, or 2;Z1is CR15bor N;R15bis hydrogen or fluoro;Z2is CH or N;R17is fluoro; and q is 0, 1, or 2.

116. The compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1, 64, or 65, having Formula (XV):wherein:Raand Rbare independently hydrogen or fluoro;R7, R8, R9, and R10are independently hydrogen or methyl;R12aand R12bare independently hydrogen or methyl; orR12aand R12btaken together with the carbon atoms to which they are attached form a 5 -membered heterocycloalkyl;Z3is CH or N.Z4is CR15bor N;R15bis hydrogen or fluoro; andZ5is CH or N.

117. The compound, or pharmaceutically acceptable salt thereof, according to claim 16, wherein R12aand R12bare independently hydrogen or methyl.

118. The compound, or pharmaceutically acceptable salt thereof, according to claim 16 having Formula (XVI):(XVI).

119. The compound according to claim 1 selected from any one or more of the compounds:(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-4-fhroro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-6-fhroro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)- 1 -methyl- lH-indol-6-yl)dihydropyrimidine-2,4( 1H,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 -methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - ethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-(trifluoromethyl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4,6-difluoro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(S * )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)pyrrolidin-3-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)pyrrolidin-3-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)-3 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)-1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-lH-pyrrolo[3,2-b]pyridin-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)- 1 -methyl- lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)-2-(l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-5-(4-((4-(3-cyclopropyl-5- (2,4-dioxotetrahydropyrimidin- 1 (2H)-yl)- lH-pyrrolo[2,3-b]pyridin- 1 -yl)piperidin- 1 -yl)methyl)-4- fluoropiperidine- 1 -carbonyl)benzonitrile;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2- (trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)meth*yl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 - (trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 - fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methoxybenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-5-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-lH-pyrrolo[3,2-b]pyridin-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-7-fluoro-lH-indol-6-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine2,4(lH,3H)-dione;(R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)- 1 -methyl- lH-indol-6-yl)dihydropyrimidine-2,4( 1H,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l -cyclobutyl- lH-indol-6-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(S)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;( S ) — 1 — ( 1 — ( 1 — ( ( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-7-fluoro-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(S)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-isopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)- 1 -cyclobutyl- lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-((3R,5 S)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3,4-dimethyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -(( 1 S,4s)-4-((4-(4-((R)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3- methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 - methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -(( 1 R,4r)-4-((4-(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-methylpiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 ,5 - difluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -(( 1 R,3 s,5 S)-8-(( 1 -(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -(( 1 R,3 s,5 S)-8-(( 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5 S *)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -(( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)azetidin-3-yl)methyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(- 1 -( 1 -(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)ethyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4,6-difluoro-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -(3 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l -cyclobutyl- lH-indol-6-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3 -methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl) -3 ,3 -difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((3R,4R)- 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-3-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-l,2-dimethyl-lH-indol-7-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,5 -difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5 R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)yridazine-4-yl)-5 -methoxypiperidin-3 - yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin-3 -yl) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine -2,4(1 H, 3H) -dione ;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)yridazine-4-yl)-4-methoxypiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)yridazine-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-(l-((l-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2S,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4( lH,3H)-dione ;1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R* )- 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((S *)- 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -(- 1 -(( 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(((R* )- 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl) -3 ,3 -difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R* )- 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R* )- 1 -(4-((S)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R* )- 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -((3 S,4S* ,5R)- 1 -(( 1 -(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -(( 1 S,4s)-4-((4-(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;rel-(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione; rel- 1 -( 1 -(( 1 R,4r)-4-((4-(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S * ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S * ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S * ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin- 2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;l-(l-((lR,4r)-4-((4-(4-((R)-l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3- yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; and(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; or pharmaceutically acceptable salts thereof.

120. The compound according to claim 1 selected from any one or more of the compounds:(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-4-fhroro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-6-fhroro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fhioropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(S)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-((3R,5 S)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3,4-dimethyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl) -3 ,3 -difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((3R,4R)- 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)-3-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,5 -difluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R*)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2- chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R*)- l-(3-amino-6-(2-hydroxyphenyl)yridazine-4-yl)-5-methoxypiperidin- 3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R*)- l-(3-amino-6-(2-hydroxyphenyl)yridazine-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)yridazine-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4( lH,3H)-dione :1 -( 1 -( 1 -(((R*)- 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3 -methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((S*)- 1 -(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -(- 1 -(( 1 -(4-((R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)-3 ,3 -difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(((R*)- 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)benzoyl)-3,3-difluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -((3 S,4S* ,5R)- 1 -(( 1 -(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lS,4s)-4-((4-(4-((R*)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -((S*)- 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 -dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -((S* )- 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -((S* )- 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin- 2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -(( 1 R,4r)-4-((4-(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - ethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-(trifluoromethyl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4,6-difluoro-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5-yl)dihydropyrimidine-2,4(lH,3H) -dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)-3 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - cyclopropylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)-2-(l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-5-(4-((4-(3-cyclopropyl-5 -(2,4-dioxotetrahydropyrimidin- 1 (2H)-yl)- IH-pyrrolo [2,3 -b]pyridin- 1 -yl)piperidin- 1 -yl)methyl)-4- fluoropiperidine- 1 -carbonyl)benzonitrile;(R*)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-2- (trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)meth*yl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 - (trifluoromethyl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 - fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methoxybenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methoxy-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-isopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -(( 1 S,4s)-4-((4-(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3-yl)-3 - methylbenzoyl)-4-methoxypiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -(( 1 R,4r)-4-((4-(4-((R)- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-methylpiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)benzoyl)- 4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5 S* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidin-3 -yl)- 3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,4S*)- l-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -( 1 -(( 1 -(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6R)-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2S,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; rel-(R)- 1 -( 1 -( 1 -(( 1 -(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzoyl)-4- fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione; and1 -( 1 -( 1 -(( 1 -(4-((R* )-4-(3 -amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-2-methyl-lH-indol-4- yl)dihydropyrimidine-2,4(lH,3H)-dione; or pharmaceutically acceptable salts thereof.

121. The compound according to claim 1 selected from any one or more of the compounds:1 — ( 1 — ( ( S ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)pyrrolidin-3-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -((3 S * ,4R* )- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin- 2-yl)benzoyl)-4-fhioropiperidin-4-yl)methyl)piperidin-3-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2-fluoro-5-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S ) — 1 — ( ( 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)pyrrolidin-3-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S * ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)azepan-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2-chlorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -((( 1 R,5 S,8 S)-3 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-3-azabicyclo[3.2.1]octan-8-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -((( 1 R,5 S,8 S)-3 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)-3-azabicyclo[3.2.1]octan-8-yl)methyl)piperidin-4-yl)-3-methyl- lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;(S * )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3-fluoropiperidin-3 - yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-3 - fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)-2- fluorobenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-5-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-((lS,4s)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R*,5R*,6S*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;l-(l-((lS,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lS,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lS,4s)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 -dimethylbenzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -methyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lS,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; rac-l-(l-((lR,4r)-4-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ; l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)- 2,5-dimethylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R*,5R*,6S*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; rac- 1 -( 1 -( 1 -(( 1 -(4-((2R,5R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((R*)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S * ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((R*)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)- 2,5-dimethylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- ethylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2- methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][l,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2,6-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-((lR,4r)-4-((4-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro- 2H-furo[3,4-b][l,4]oxazin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][l,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2,6-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][l,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2,6-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -(3 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l-cyclobutyl-7-fluoro-lH-indol-6- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-lH-pyrrolo[2,3-b]pyridin- 5 -yl)dihydropyrimidine -2,4( 1 H, 3H) -dione ;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -fluoropiperidin-3 - yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-4-fluoro-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((3R* ,5R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 -methoxypiperidin- 3 -yl)-3 -methylbenzoyl)piperidin-4-yl)methyl)-3 ,3 -difluoropiperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 - b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)piperidin-4-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( (R) - 1 -(( 1 -(4-((R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3 - methylbenzoyl)piperidin-4-yl)methyl)pyrrolidin-3-yl)-lH-indol-4-yl)dihydropyrimidine-2,4(lH,3H)- dione; l-(l-((lR,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-l-yl)methyl)cyclohexyl)-3-methyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5 - dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -( 1 -(( 1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,3 - dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;1 — ( 1 — ( ( S * ) — 1 — ( ( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)azepan-4-yl)-3-methyl-lH-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2R* ,6R* )-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- (fluoromethyl)morpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-lH- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(lH,3H)-dione;1 -( 1 -(( 1 S,4s)-4-((4-(4-((R* )- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)benzyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -cyclopropyl- IH-pyrrolo [2,3 -b]pyridin-5 - yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -(7 -((1 -(4-(4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2- yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-2-methyl-lH-indol-4-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R)- 1 -( 1 -( 1 -( 1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -yl)benzyl)-4- fluoropiperidine-4-carbonyl)piperidin-4-yl)-3-methyl-lH-indol-5-yl)dihydropyrimidine-2,4(lH,3H)- dione;1 -( 1 -((S * )- 1 '-(4-((R)- 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 -y 1) -3 - methylbenzoyl)-[l,3'-bipiperidin]-4-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine- 2,4(lH,3H)-dione;(R* )- 1 -( 1 -(7 -((1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione;(R* )- 1 -( 1 -(7 -((1 -(4-( 1 -(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidin-3 - yl)phenyl)piperidin-4-yl)methyl)-7-azaspiro[3.5]nonan-2-yl)-3-cyclopropyl-lH-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; l-(l-(l-((l-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; and l-(l-(l-((l-(4-((2S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2- yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-lH-indol-5- yl)dihydropyrimidine-2,4(lH,3H)-dione; or pharmaceutically acceptable salts thereof.

122. The compound according to claim 1 selected from any one or more of the compounds:1 -( 1 -((3S,4R)- 1 -(( 1 -(4 -( (2 A.6.S) -4 -( 3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-lH- pyrrolo| 2.3- / ? |pyridin-5-yl)dihydropyrimidinc-2.4( 17 / .3 / / )-dionc:1 -( 1 -((3R,45)- 1 -(( 1 -(4-((2R,6S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3 -fluoropiperidin-4-yl)-3 -methyl- IH-pyrrolo [2,3 - 6]pyridin-5-yl)dihydropyrimidine-2,4(lH,327)-dione;1 -( 1 -((3S,4R)- 1 -(( 1 -(4 -( (2 A.6.S) -4 -( 3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indol- 5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4s)-4-((4-(4-((R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-2-methyl-1H-indol-4-yl)dihydropyrimidine- 2,4(1H,3H)-dione; 1-(1-((1R,4s)-4-((4-(4-((S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3- methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-2-methyl-1H-indol-4-yl)dihydropyrimidine- 2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5-yl)dihydropyrimidine-2,)- dione; 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2S,4s,6S)-6-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2R,4r,6R)-6-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed)); 1-(1-((1R,4r)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed)); 1-(1-((1S,4s)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed)); 1-(1-((1S,4s)-4-((4-(4-((3R*,5R*)-1-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methoxypiperidin-3-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (Isomer 1) ((*absolute configuration not yet confirmed)); 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4R)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione;1-(1-((3S,4R)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1R,4r)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-5-yl)dihydropyrimidine-2,4(1H,3H)- dione; 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;1 -( 1 -( 1 -(( 1 -(4-((2.S'.5.S'.6 / ?)-4-(3-Amino-6-(2-hydroxyphcnyl)pyridazin-4-yl)-5.6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-l / -indol-5- yl)dihydropyrimidine-2,4( l / / .3 / / )-dionc:1 -( 1 -( 1 -(( 1 -(4-((2 / ?.6.S)-4-(3- Am i no-6-(2-hydroxyphcnyl )py ridazi n-4-yl )-6-mcthyl morphol i n-2- yl)-2,5 -dimethylbenzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3 -methyl- I / / -pyrrol o [2,3 - / | py ridin-5 - yl)dihydropyrimidinc-2.4( l / / .3 / / )-dionc: l-(l-((lS,45)-4-((4-(4-((2J?,5J?)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin- 1 -yl)methyl)cyclohexyl)-3 -ethyl- I / / -py rrolo 12.3 - / | py ridin-5 - yl)dihydropyrimidinc-2.4( l / / .3 / / )-dionc:1 -( 1 -( 1 -(( 1 -(4-((2 / ?.5 / ?)-4-(3- Am i no-6-(2-hydroxyphcnyl )py ridazi n-4-yl )-5 -methylmorpholin-2- yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-l / -indol-5-yl)dihydropyrimidine- 2, 4(177,377) -dione;1 -( 1 -( 1 -(( 1 -(4-((27?,57?,65)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl- l / / -indol-5-yl)dihydropyrimidmc-2.4( l / / .3 / / )-dionc:1 -( 1 -( 1 -(( 1 -(4-((2S,5S,67?)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl- l / / -indol-5-yl)dihydropyrimidmc-2.4( l / / .3 / / )-dionc:1 -( 1 -( 1 -(( 1 -(4-((27?,57?,65)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl-177-indol- 5-yl)dihydropyrimidine-2, 4( 1 / / .3H) -dione;1 -( 1 -( 1 -(( 1 -(4-((2S,5S,67?)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-6-methyl-l / / -indol- 5-yl)dihydropyrimidine-2,4(l / / ,3 / / )-dione;1 -( 1 -((37?, 45)- 1 -(( 1 -(4-((27?,65)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methyhnorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-17 / - pyrrolo| 2.3-A |pyridin-5-yl)dihydropyrimidinc-2.4( I / / .3 / / )-dionc:1 -( 1 -((3S,47?)- 1 -(( 1 -(4-((2 / ?.6.S)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methyhnorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-17 / - pyrrolo| 2.3-A |pyridin-5-yl)dihydropyrimidinc-2.4( I / / .3 / / )-dionc:1 -( 1 -( 1 -(( 1 -(4-((2 / ?.5 / ?.6.S')-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-177- pyrrolo| 2.3-A |pyridin-5-yl)dihydropyrimidinc-2.4( I / / .3 / / )-dionc:1 -( 1 -( 1 -(( 1 -(4-((2S,5S,6J?)-4-(3 -Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5 ,6- dimethylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-l / - pyrrolo| 2.3-A |pyridin-5-yl)dihydropyrimidinc-2.4( I / / .3 / / )-dionc:1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4R)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4R)-1-((1-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3S,4R)-1-((1-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-2-methyl-1H-indol-4- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro- 2H-furo[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-6-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;1-(1-((2r,5R)-2-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-ethyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)spiro[3.3]heptan-2-yl)-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2-methylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-methyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((3R,4S)-1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro- 2H-furo[3,4-b][1,4]oxazin-2-yl)-2-methylbenzoyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3- methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H- furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione;1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholin-2- yl)-2,5-dimethylbenzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H- pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indol-5- yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6- methylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(3-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(3,5-difluoro-2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6- dimethylmorpholin-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(1-(1-((1-(4-((2R,5R)-4-(3-Amino-6-(5-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-5- methylmorpholin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione; and 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-Amino-6-(5-fluoro-2-hydroxyphenyl)pyridazin-4- yl)hexahydro-2H-furo[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin- 4-yl)-6-methyl-1H-indol-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, or pharmaceutically acceptable salts thereof.

123. A pharmaceutical composition comprising the compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, and a pharmaceutically acceptable excipient.

124. A method of degrading SMARCA2 protein in a human, comprising administering to a human in need thereof an effective amount of the compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, or the composition of claim 123.

125. A method of reducing the level of SMARCA2 activity in a human, comprising administering to a human in need thereof an effective amount of the compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, or the composition of claim 123.

126. A method of treating cancer in a human, comprising administering to a human in need thereof an effective amount of the compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, or the composition of claim 123.

127. The method of claim 126, wherein the cancer is a SMARCA2-sensitive cancer.

128. The method of claim 126, wherein the cancer is a SMARCA2 -mutated cancer.

129. The method of any one of claims 126-128, wherein the cancer is a solid tumor.

130. The method of any one of claims 126-128, wherein the cancer is lung, liver, colon, skin, bladder, cervical or ovarian cancer.

131. A compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1 - 122, or the composition of claim 123 for use in degrading SMARCA2 protein in a human.

132. A compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, or the composition of claim 123 for use in reducing the level of SMARCA2 activity in a human.

133. A compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, or the composition of claim 123 for use in treating cancer in a human.

134. The compound for use of claim 133, wherein the cancer is a SMARCA2-sensitive cancer.

135. The compound for use of claim 133, wherein the cancer is a SMARCA2 -mutated cancer.

136. The compound for use of any one of claims 133-135, wherein the cancer is a solid tumor.

137. The compound for use of any one of claims 133-135, wherein the cancer is lung, liver, colon, skin, bladder, cervical or ovarian cancer.

138. Use of a compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, or the composition of claim 123 in the manufacture of a medicament for degrading SMARCA2 protein in a human.

139. Use of a compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1-122, or the composition of claim 123 in the manufacture of a medicament for reducing the level of SMARCA2 activity in a human.

140. Use of a compound, or pharmaceutically acceptable salt thereof, according to any one of claims 1- 122, or the composition of claim 123 in the manufacture of a medicament for treating cancer in a human.

141. The compound, or pharmaceutical acceptable salt thereof, for use of claim 140, wherein the cancer is a SMARCA2-sensitive cancer.

142. The compound, or pharmaceutically acceptable salt thereof, for use of claim 140, wherein the cancer is a SMARCA2 -mutated cancer.

143. The compound for use of any one of claims 141-143, wherein the cancer is a solid tumor.

144. The compound for use of any one of claims 141-143, wherein the cancer is lung, liver, colon, skin, bladder, cervical or ovarian cancer.

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