Process for preparing gamma,delta-unsaturated aldehydes derivatives

Abstract

The present invention relates to the field of organic synthesis and more specifically it concerns a process for preparing compound of formula (II) starting from compound of formula (I) and a process for preparing compound of formula (I) via valuable new chemical intermediates such as compound of formula (IV) and the compound of formula (V). The compound (IV) and the compound of formula (V) are also part of the invention.

Description

[0001] Firmenich SA 1 PROCESS FOR PREPARING GAMMA,DELTA-UNSATURATED ALDEHYDES DERIVATIVES Technical field The present invention relates to the field of organic synthesis and more specifically it concerns a process for preparing compound of formula (II) starting from compound of formula (I) and a process for preparing compound of formula (I) starting from compound of formula (III) via valuable new chemical intermediates such as compound of formula (IV) and the compound of formula (V). The compound (IV) and the compound of formula (V) are also part of the invention. Background of the invention In the perfumery industry, there is a constant need to provide compounds imparting novel organoleptic notes. In particular, there is an interest towards ingredients imparting the lily of the valley odor or at least one of the key organoleptic facets of the lily of the valley odor. So, compounds imparting said note are particularly sought after to reconstitute the delicate floral odor of muguet which does not survive even the mildest of extraction methods to yield an essential oil. Towards this goal, compounds of formula (II) were previously reported in WO2010 / 052635 or in WO2015 / 000821. Said compounds have been prepared via a Johnson-Claisen rearrangement followed by reduction and oxidations requesting non catalytic and toxic reagents such as hydride or pyridinium chlorochromate or directly via a Claisen rearrangement. However, the rearrangement step provides the desired intermediate or product with moderate to low yield. Being products of industrial interest, there is always a need for new processes showing an improved yield and productivity. In the meantime, today there is a need to foster sustainable processes, for examples using enzymatic transformation. The present invention allows to solve the above problems by using an oxidoreductase in the process to prepare compound of formula (II). The process herein disclosed represents a novel route through novel intermediates, never disclosed before, while improving yield and environmental impact. To the best of our knowledge, the invention’s conditions and the compounds of formula (IV) and (V) which are an object of the present invention, have never been reported in the prior art. Firmenich SA 2 Summary of the Invention The invention relates to a novel process allowing the preparation of compound of formula (II) with a high yield and high selectivity starting from compound of formula (III) via compound of formula (IV), (V) and (I). The invention process represents a new efficient route toward compound of formula (II). So, the first object of the present invention is a process for the reduction by hydrogenation of conjugated dienal of formula in the form of any and wherein each R1, R23 and R , a atom, a C1-3 alkoxy group, a C1-6 alkyl group or a C2-6 alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8 cycloalkyl or C5-8 cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; into a deconjugated enal of formula in the form of any one and wherein R1to R6 have the same meaning as defined in formula (I); said process being carried out in the presence of an oxidoreductase. A second object of the present invention is a process for the preparation of a compound of formula Firmenich SA 3 in the form of any one of its or a mixture thereof, and wherein each R1, R2and R3, independently from each other, represent a hydrogen atom, a C1-3 alkoxy group, a C1-6 alkyl group or a C2-6 alkenyl group, each optionally substituted by a hydroxy or C1-3alkoxy group; or R1and R2, are taken together and form a C3-8 cycloalkyl or C5-8 cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; comprising the steps of a) converting a compound of formula in the form of thereof, and wherein R1, R2, R3, R4and R5have the same meaning as defined in formula (I); into an acetal of formula in the form of1 thereof, and wherein R , R2, R3,R4and R5have the same meaning as defined in formula (I); Raand Rb, independently from each other, represent a C1-4 alkyl group or Raand Rb, when taken together, represent a C2-5alkanediyl group; b) treating the acetal obtained in step a) with an acid and a compound of formula R6-CH=CH-ORc; wherein R6has the same meaning as defined in formula (I) and Rcrepresents a C1-4 alkyl group; to obtain a compound of formula Firmenich SA 4 in the form of any one1 2 3 and wherein R , R , R,R4, R5, R6, Ra, Rband Rchave the same meaning as defined above; and c) treating the compound of formula (V) with an acid to obtain a compound of formula (I). A third object of the present invention is a compound of formula in the form of any one1 2 and wherein R , R and R3, independently from each other, represent a hydrogen atom, a C1-3alkoxy group, a C1-6alkyl group or a C2-6 alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8cycloalkyl or C5-8cycloalkenyl group; R4and R5, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4alkyl group or Raand Rb, when taken together, represent a C2-5 alkanediyl group. A further object of the present invention is a compound of formula in the form of and and wherein R1, R2and R3, independently from each other, represent a hydrogen atom, a C1-3 alkoxy group, a C1-6alkyl group or a C2-6alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3- Firmenich SA 5 8 cycloalkyl or C5-8 cycloalkenyl R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4 alkyl group or Raand Rb, when taken together, represent a C2-5alkanediyl group; Rcrepresents a C1-4alkyl group. A further object of the present invention is a compound of formula (I) and / or formula (II) and an oxidoreductase. A further object of the present invention is a reaction medium comprising an oxidoreductase enzyme according to the invention and a compound of formula (I) and / or formula (II). A further object of the present invention is a compound of formula (II) obtained or obtainable by the process of the invention. Description of the invention It has now been surprisingly found that the perfuming ingredients of formula (II) can be obtained from a new class of precursors (or chemical intermediates), as defined herein below in formula (IV) and (V), and that said new intermediates allow the corresponding perfuming ingredients to be obtained with overall higher yield, compared to the methods known from the prior art and using more sustainable conditions. So, the first object of the invention is a process for the reduction by hydrogenation of conjugated dienal of formula in the form of any and wherein each R1, R23 and R , a atom, a C1-3 alkoxy group, a C1-6alkyl group or a C2-6alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8 cycloalkyl or C5-8 cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; into a deconjugated enal of formula Firmenich SA 6 in the form of any one and wherein R1to R6have the same meaning as defined in formula (I); said process being carried out in the presence of an oxidoreductase. For the sake of clarity, by the expression “any one of its stereoisomers or a mixture thereof”, or the similar, it is meant the normal meaning understood by a person skilled in the art, i.e. that the compounds of formula (I) and (II) can be a pure enantiomer or a mixture of enantiomers. In other words, the compounds of formula (I) and (II) may possess at least one stereocenter which can have two different stereochemistries (e.g. R or S). The compounds of formula (I) and (II) may even be in the form of a pure enantiomer or in the form of a mixture of enantiomers. The compounds of formula (I) and (II) may even be in the form of a pure diastereoisomer or in the form of a mixture of diastereoisomers when compounds of formula (I) and (II) possess more than one stereocenter. The compounds of formula (I) and (II) can be in a racemic form or scalemic form. Therefore, the compounds of formula (I) and (II) can be one stereoisomer or in the form of a composition of matter comprising, or consisting of, various stereoisomers. For the sake of clarity, by the wavy bond in compound of formula (II), or the similar, it is meant the normal meaning understood by a person skilled in the art, i.e. that the double bond may have a cis configuration corresponding to the Z isomer, a trans configuration corresponding to the E isomer or a mixture thereof. In other words, the compound of formula (II) may be in the form of its E or Z isomer or of a mixture thereof, e.g. the invention process leads to a composition of matter consisting of one or more compounds of formula (II), having the same chemical structure but differing by the configuration of the double bond. In particular, compound (II) can be in the form of a mixture consisting of isomers E and Z and wherein said isomer E represents at least 25% of the total mixture, at least 35%, at least 50%, or even at least 75% (i.e a mixture E / Z comprised between 75 / 25 and 100 / 0), or even at least 88%, or even at least 95%. Firmenich SA 7 The terms “alkyl” and “alkenyl” are as comprising branched and linear alkyl and alkenyl groups. The terms “alkenyl” and “cycloalkenyl” are understood as comprising 1, 2 or 3 olefinic double bonds, preferably 1 or 2 olefinic double bonds. The terms “cycloalkyl” and “cycloalkenyl” are understood as comprising a monocyclic or fused, spiro and / or bridged bicyclic or tricyclic cycloalkyl and cycloalkenyl, groups, preferably monocyclic cycloalkyl and cycloalkenyl groups. For the sake of clarity, by the expression “R1and R2, are taken together and form a C3-8cycloalkyl or C5-8cycloalkenyl group”, it is meant that the carbon atoms to which both groups are bonded are included into the C5-8 cycloalkyl or C5-8 cycloalkenyl group. The term “optionally” is understood that a certain group to be optionally substituted can or cannot be substituted with a certain functional group. According to any embodiment of the invention, R4may be a hydrogen atom or a methyl group. Even more particularly, R4may be a hydrogen atom. According to any embodiment of the invention, R5may be a methyl or an ethyl group. Even more particularly, R5may be a methyl group. According to any embodiment of the invention, R6may be a hydrogen atom or a methyl group. Even more particularly, R6may be a hydrogen atom. According to any embodiment of the invention, R3may be, independently from each other, a hydrogen atom, a methoxy group, an ethoxy group, a C1-4 alkyl group or a C2-4 alkenyl group, each optionally substituted by a hydroxy, methoxy or ethoxy group. Particularly, R3may be, independently from each other, a hydrogen atom, a C1-3 alkyl group or a C2-3alkenyl group, each optionally substituted by a hydroxy or methoxy group. Particularly, R3may be, independently from each other, a hydrogen atom or a C1-3 alkyl group. Particularly, R3may be, independently from each other, a hydrogen atom or a methyl or ethyl group. Even more particularly, R3may be a hydrogen atom. According to any embodiment of the invention, the compound of formula (I) is of formula in the form of any and wherein each R1 and R2have the same as and said compound of formula (II) is of formula Firmenich SA 8 in the form of any and wherein each R12 and R have the same as According to any embodiment of the invention, R1may be, independently from each other, a hydrogen atom, a methoxy group, an ethoxy group, a C1-4alkyl group or a C2-4alkenyl group, each optionally substituted by a hydroxy, methoxy or ethoxy group. Particularly, R1may be, independently from each other, a hydrogen atom, a C1-3alkyl group or a C2-3 alkenyl group, each optionally substituted by a hydroxy or methoxy group. Particularly, R1may be, independently from each other, a hydrogen atom or a C1-3alkyl group. Particularly, R1may be, independently from each other, a hydrogen atom or a methyl or ethyl group. Even more particularly, R1may be a methyl group. According to any embodiment of the invention, R2may be, independently from each other, a hydrogen atom, a methoxy group, an ethoxy group, a C1-4alkyl group or a C2-4alkenyl group, each optionally substituted by a hydroxy, methoxy or ethoxy group. Particularly, R2may be, independently from each other, a hydrogen atom, a C1-3alkyl group or a C2-3 alkenyl group, each optionally substituted by a hydroxy or methoxy group. Particularly, R2may be, independently from each other, a hydrogen atom or a C1-3alkyl group. Particularly, R2may be, independently from each other, a hydrogen atom or a methyl or ethyl group. Even more particularly, R2may be a hydrogen atom. Non limiting examples of compound of formula (II) may include (E)-4-methyl-5- (p-tolyl)pent-4-enal, (4E)-2,4-dimethyl-5-(4-methylphenyl)-4-pentenal, (4E)-4-methyl-5- (3-methylphenyl)-4-pentenal, (E)-5-(4-ethylphenyl)-4-methylpent-4-enal, (E)-5-(4- isopropylphenyl)-4-methylpent-4-enal, (E)-5-(4-methoxyphenyl)-4-methylpent-4-enal, (E)-5-(2,3-dihydro-1H-inden-5-yl)-4-methylpent-4-enal, (E)-5-(1,1-dimethyl-2,3-dihydro- 1H-inden-5-yl)-4-methylpent-4-enal, (Z)-4-methyl-5-(p-tolyl)pent-4-enal, (4Z)-2,4- dimethyl-5-(4-methylphenyl)-4-pentenal, (4Z)-4-methyl-5-(3-methylphenyl)-4-pentenal, (Z)-5-(4-ethylphenyl)-4-methylpent-4-enal, (Z)-5-(4-isopropylphenyl)-4-methylpent-4- enal, (Z)-5-(4-methoxyphenyl)-4-methylpent-4-enal, (Z)-5-(2,3-dihydro-1H-inden-5-yl)-4- methylpent-4-enal, (Z)-5-(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)-4-methylpent-4-enal, 4-methyl-5-(p-tolyl)pent-4-enal, 2,4-dimethyl-5-(4-methylphenyl)-4-pentenal, 4-methyl- 5-(3-methylphenyl)-4-pentenal, 5-(4-ethylphenyl)-4-methylpent-4-enal, 5-(4- Firmenich SA 9 isopropylphenyl)-4-methylpent-4-enal, 5- -4-methylpent-4-enal, 5-(2,3- dihydro-1H-inden-5-yl)-4-methylpent-4-enal or 5-(1,1-dimethyl-2,3-dihydro-1H-inden-5- yl)-4-methylpent-4-enal. Non limiting examples of compound of formula (I) may include (2E,4E)-4-Methyl- 5-(4-methylphenyl)-2,4-pentanedienal, (2E,4E)-2,4-dimethyl-5-(p-tolyl)penta-2,4-dienal, (2E,4E)-4-methyl-5-(m-tolyl)penta-2,4-dienal, (2E,4E)-5-(4-ethylphenyl)-4-methylpenta- 2,4-dienal, (2E,4E)-5-(4-isopropylphenyl)-4-methylpenta-2,4-dienal, (2E,4E)-5-(4- methoxyphenyl)-4-methylpenta-2,4-dienal, (2E,4E)-5-(2,3-dihydro-1H-inden-5-yl)-4- methylpenta-2,4-dienal, (2E,4E)-5-(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)-4- methylpenta-2,4-dienal, (2E,4Z)-4-Methyl-5-(4-methylphenyl)-2,4-pentanedienal, (2E,4Z)-2,4-dimethyl-5-(p-tolyl)penta-2,4-dienal, (2E,4Z)-4-methyl-5-(m-tolyl)penta-2,4- dienal, (2E,4Z)-5-(4-ethylphenyl)-4-methylpenta-2,4-dienal, (2E,4Z)-5-(4- isopropylphenyl)-4-methylpenta-2,4-dienal, (2E,4Z)-5-(4-methoxyphenyl)-4- methylpenta-2,4-dienal, (2E,4Z)-5-(2,3-dihydro-1H-inden-5-yl)-4-methylpenta-2,4-dienal, (2E,4Z)-5-(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)-4-methylpenta-2,4-dienal, (2Z,4E)- 4-Methyl-5-(4-methylphenyl)-2,4-pentanedienal, (2Z,4E)-2,4-dimethyl-5-(p-tolyl)penta- 2,4-dienal, (2Z,4E)-4-methyl-5-(m-tolyl)penta-2,4-dienal, (2Z,4E)-5-(4-ethylphenyl)-4- methylpenta-2,4-dienal, (2Z,4E)-5-(4-isopropylphenyl)-4-methylpenta-2,4-dienal, (2Z,4E)-5-(4-methoxyphenyl)-4-methylpenta-2,4-dienal, (2Z,4E)-5-(2,3-dihydro-1H- inden-5-yl)-4-methylpenta-2,4-dienal, (2Z,4E)-5-(1,1-dimethyl-2,3-dihydro-1H-inden-5- yl)-4-methylpenta-2,4-dienal, 4-Methyl-5-(4-methylphenyl)-2,4-pentanedienal, 2,4- dimethyl-5-(p-tolyl)penta-2,4-dienal, 4-methyl-5-(m-tolyl)penta-2,4-dienal, 5-(4- ethylphenyl)-4-methylpenta-2,4-dienal, 5-(4-isopropylphenyl)-4-methylpenta-2,4-dienal, 5-(4-methoxyphenyl)-4-methylpenta-2,4-dienal, 5-(2,3-dihydro-1H-inden-5-yl)-4- methylpenta-2,4-dienal, 5-(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)-4-methylpenta-2,4- dienal. The term “polypeptide” means an amino acid sequence of consecutively polymerized amino acid residues, for instance, at least 15 residues, at least 30 residues, at least 50 residues. In some embodiments herein, a polypeptide comprises an amino acid sequence that is an enzyme, or a fragment, or a variant thereof. The term “protein” refers to an amino acid sequence of any length wherein amino acids are linked by covalent peptide bonds, and includes oligopeptide, peptide, polypeptide and full length protein whether naturally occurring or synthetic. Firmenich SA 10 The term “isolated” polypeptide to an amino acid sequence that is removed from its natural environment by any method or combination of methods known in the art and includes recombinant, biochemical and synthetic methods. The terms “nucleic acid sequence,” “nucleic acid,” “nucleic acid molecule” and “polynucleotide” are used interchangeably meaning a sequence of nucleotides. A nucleic acid sequence may be a single-stranded or double-stranded deoxyribonucleotide, or ribonucleotide of any length, and include coding and non-coding sequences of a gene, exons, introns, sense and anti-sense complimentary sequences, genomic DNA, cDNA, miRNA, siRNA, mRNA, rRNA, tRNA, recombinant nucleic acid sequences, isolated and purified naturally occurring DNA and / or RNA sequences, synthetic DNA and RNA sequences, fragments, primers and nucleic acid probes. The skilled artisan is aware that the nucleic acid sequences of RNA are identical to the DNA sequences with the difference of thymine (T) being replaced by uracil (U). The term “nucleotide sequence” should also be understood as comprising a polynucleotide molecule or an oligonucleotide molecule in the form of a separate fragment or as a component of a larger nucleic acid. An “isolated nucleic acid” or “isolated nucleic acid sequence” relates to a nucleic acid or nucleic acid sequence that is in an environment different from that in which the nucleic acid or nucleic acid sequence naturally occurs and can include those that are substantially free from contaminating endogenous material. The term “naturally-occurring” as used herein as applied to a nucleic acid refers to a nucleic acid that is found in a cell of an organism in nature and which has not been intentionally modified by a human in the laboratory. “Recombinant nucleic acid sequences” are nucleic acid sequences that result from the use of laboratory methods (for example, molecular cloning) to bring together genetic material from more than on source, creating or modifying a nucleic acid sequence that does not occur naturally and would not be otherwise found in biological organisms. “Recombinant DNA technology” refers to molecular biology procedures to prepare a recombinant nucleic acid sequence as described, for instance, in Laboratory Manuals edited by Weigel and Glazebrook, 2002, Cold Spring Harbor Lab Press; and Sambrook et al., 1989, Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press. The term “gene” means a DNA sequence comprising a region, which is transcribed into a RNA molecule, e.g., an mRNA in a cell, operably linked to suitable regulatory regions, e.g., a promoter. A gene may thus comprise several operably linked sequences, Firmenich SA 11 such as a promoter, a 5’ leader sequence e.g., sequences involved in translation initiation, a coding region of cDNA or genomic DNA, introns, exons, and / or a 3’non- translated sequence comprising, e.g., transcription termination sites. “Expression of a gene” encompasses “heterologous expression” and “over- expression” and involves transcription of the gene and translation of the mRNA into a protein. Overexpression refers to the production of the gene product as measured by levels of mRNA, polypeptide and / or enzyme activity in transgenic cells or organisms that exceeds levels of production in non-transformed cells or organisms of a similar genetic background. “Expression vector” as used herein means a nucleic acid molecule engineered using molecular biology methods and recombinant DNA technology for delivery of foreign or exogenous DNA into a host cell. The expression vector typically includes sequences required for proper transcription of the nucleotide sequence. The coding region usually codes for a protein of interest but may also code for an RNA, e.g., an antisense RNA, siRNA and the like. An “expression vector” as used herein includes any linear or circular recombinant vector including but not limited to viral vectors, bacteriophages and plasmids. The skilled person is capable of selecting a suitable vector according to the expression system. In one embodiment, the expression vector includes the nucleic acid of an embodiment herein operably linked to at least one regulatory sequence, which controls transcription, translation, initiation and termination, such as a transcriptional promoter, operator or enhancer, or an mRNA ribosomal binding site and, optionally, including at least one selection marker. Nucleotide sequences are “operably linked” when the regulatory sequence functionally relates to the nucleic acid of an embodiment herein. The term “primer” refers to a short nucleic acid sequence that is hybridized to a template nucleic acid sequence and is used for polymerization of a nucleic acid sequence complementary to the template. As used herein, the term “host cell” or “transformed cell” refers to a cell (or organism) altered to harbor at least one nucleic acid molecule, for instance, a recombinant gene encoding a desired protein or nucleic acid sequence. The host cell is particularly a bacterial cell, a fungal cell or a plant cell. The host cell may contain a recombinant gene which has been integrated into the nuclear or organelle genomes of the host cell. Alternatively, the host may contain the recombinant gene extra-chromosomally. Methods for introducing nucleic acid sequences into cells are well known in the art. For example, Firmenich SA 12 where the cell is a prokaryotic cell (e.g. coli), then such methods include among others heat shock of chemically prepared competent cells (chemical transformation) and electroporation of electrocompetent cells. Both techniques are well-known and no further explanation is needed. Where the cell is a eukaryotic cell such as a fungal cell, the most widely methods used for transformation are for example ATMT, PEG-mediated protoplast transformation, and electroporation. There are very few examples of oxidoreductase known in the art, specifically ene reductase, catalyzing selective reduction of conjugated dienals (α,β,γ,δ-di-unsaturated aldehyde). These few examples typically use aliphatic substrates at very low substrate concentrations that are not suitable for industrial application (see for example Miyamura et al., Agric. Biol. Chem., 1984, 48, 185-192; Chaparro-Riggers et al., Adv. Synth. Catal., 2007, 349, 1521-1531). There is only one example of the reduction of an aromatic conjugated dienal, reported by Mathew et al., 2018 (Chem. Commun.2018, 54, 11208-11211). This example used substrate screening with very low substrate concentrations of only 1 mM and the only tested dienal contains a hydrogen on any of positions R4, R5and R6of formula (I). Additionally, the document reports using F420H2-dependent enzymes, which use unusual cofactors that currently cannot be used on industrial scale as there is no suitable cofactor regeneration system. Furthermore, the authors report that the enzymes are not stable which makes such biocatalytic method unsuitable for industrial applications. It is also noteworthy to mention that this enzyme family is not related to any so far known ene reductase families, in particular to any of the enzyme families disclosed herein. It is well known that substrates with an aryl group are significantly bulkier than aliphatic substrates and it has been observed that these molecules are less efficiently converted by enzymes. In particular, if R4, R5and / or R6of formula (I) are a methyl or an ethyl group, additional steric hindrances in the active site of ene reductases are present. Unsurprisingly, so far no compound of formula (I) with a methyl or an ethyl group at R4, R5and / or R6has been converted with an enzyme to reduce the α,β-double bond. Thus, there is a need for an efficient ene reductase that can selectively reduce conjugated dienals with an aryl group. The process for making a compound of formula (II) comprises reducing a precursor compound of formula (I) with an oxidoreductase enzyme. Firmenich SA 13 An oxidoreductase is an enzyme catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. Oxidoreductases comprise the large class of enzymes that catalyze biological oxidation / reduction reactions. Because many chemical and biochemical transformations involve oxidation / reduction processes, oxidoreductases have much utility in the development of biotech methods of synthesis of desirable compounds. There are several different classes of oxidoreductases which are primarily defined according to their substrate and / or mode of action. For example, ene reductases, ketoreductases, peroxidases, hydroxylases and oxygenases, and reductases. Preferably the oxidoreductase is an ene reductase (also termed ERED herein). Ene reductase, also called alkene reductase or double bond reductase or enoate reductase or olefin reductase or enoyl reductase or ERED, can reduce the C=C in substrates of activated double bonds like enal, enones and enoates. They belong to various enzyme families and thus also EC numbers. These enzymes use NADPH or NADH as cofactors. The vast majority of ene reductases belong to the superfamily Old Yellow Enzymes (EC 1.6.99.1). Members of the Old Yellow Enzyme family are NAD(P)H-dependent oxidoreductases which catalyze the stereo- and enantioselective reduction of α,β- unsaturated ketones, aldehydes, nitro alkenes, and carboxylic acids. OYEs can be found in bacteria, fungi and plants and are divided in several subfamilies depending on their sequence homology and structural features. Examples of OYEs are represented by SEQ ID NOs: 11 to 44. The catalytic site of OYEs harbors a flavin mononucleotide (FMN) cofactor, which donates a hydride to the Cb atom of the substrate. In addition, it usually comprises a pair of amino acid residues (typically histidine / histidine or asparagine / histidine) that act as H- bonding donors to the electron-withdrawing group of the substrate, and a conserved tyrosine residue (in some cases a cysteine), which is necessary to deliver a proton onto the Ca atom during turnover. Hence in certain embodiments, where the enzyme used in the method of the invention requires an FMN cofactor, said cofactor may be introduced to the reaction. However, in most performances of the invention the growth media provides sufficient quantities of the FMN cofactor so that it is not necessary to further supplement the reaction with this compound. Firmenich SA 14 Other members of the ene family belong to the NAD(P)H-dependent medium chain dehydrogenase / reductase (MDR) family (EC 1.3.1). More specifically, SEQ ID NOs: 1 to 7 are double bond reductase-like enzymes (DBR, cd08295) and SEQ ID NOs: 8 to 10 belong to the prostaglandin dehydrogenase subfamily (PGDH, cd05288). The MDR family of EREDs does not contain any bound cofactor such as FMN and have been shown to catalyze the reduction of the C=C double bonds of α,β-unsaturated ketones, aldehydes, and carboxylic acids. This is the first time that the MDR family of EREDs has been reported for the specific reduction of the α,β-double bond in a compound of formula (I). Hence an embodiment of the invention is wherein the ERED is a MDR. A preferred embodiment of the invention is wherein the ene reductase (ERED) enzyme has at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity of any of SEQ ID NOs: 1 to 44. As is known by those of skill in the art, ERED reactions typically require a cofactor. As used herein, the term "cofactor" refers to a non-protein compound that operates in combination with an ERED enzyme. Cofactors suitable for use with the ERED enzymes in the processes of the invention described herein include, but are not limited to, NADP+(nicotinamide adenine dinucleotide phosphate), NADPH (the reduced form of NADP+, NAD+(nicotinamide adenine dinucleotide) and NADH (the reduced form of NAD+). Generally, where the process does not use a cofactor regeneration system (described further below), the reduced form of the cofactor is added to the reaction mixture. An embodiment of the process of the invention is wherein the ERED reduction is performed in the presence of a cofactor; preferably the cofactor is NAD(P)H or NAD(P)+. The reduced NAD(P)H form can be optionally regenerated from the oxidized NAD(P)+form using a cofactor regeneration system. One benefit of using a cofactor regenerating system is that such a system can push the equilibrium of the process of the invention towards the generation of the desired product. In this way, the process of the invention can be more optimized and efficient in terms of reagents used, therefore more time and cost effective than without the use of a cofactor regenerating system. Hence an embodiment of the process of the invention is wherein the ERED reduction is performed in the presence of a cofactor regeneration system. The term "cofactor regeneration system" refers to a set of reactants that participate in a reaction that reduces the oxidized form of the cofactor (e.g., NAD(P)+to NAD(P)H). Firmenich SA 15 Cofactors oxidized by the ERED- of the substrate are regenerated in reduced form by the cofactor regeneration system. Cofactor regeneration systems comprise a stoichiometric reductant that is a source of reducing hydrogen equivalents and is capable of reducing the oxidized form of the cofactor. The cofactor regeneration system may further comprise a catalyst, for example a cofactor regeneration enzyme, that catalyzes the reduction of the oxidized form of the cofactor by the reductant. Cofactor regeneration systems to regenerate NADH or NADPH from NAD+or NADP+, respectively, are known in the art and may be used in the processes described herein. The cofactor regeneration system can be in vivo or in vitro. While not wishing to be bound to any specific embodiments, examples of in vivo cofactor regeneration systems include where the cofactor regeneration enzyme that catalyzes the reduction of the oxidized form of the cofactor by the ERED, is synthesized in a cell which also synthesizes the ERED enzyme. Hence there is a cofactor regeneration within a single cell. In such embodiments the cell is genetically modified to express both the ERED enzyme and the cofactor regeneration enzyme. Examples of polypeptide sequences encoding the ERED enzyme provided herein. Preferably the cofactor regeneration enzyme is an alcohol dehydrogenase (ADH), a formate dehydrogenase (FDH), a glucose dehydrogenase (GDH), a phosphite dehydrogenase, or a 6-phosphate glucose dehydrogenase, and examples of such enzymes and their polypeptide sequences are well known in the art. Wild type organisms such as baker’s yeast have been traditionally used for the reduction of alkenes using e.g. glucose as the co-substrate. Alternatively, the cofactor regeneration system is an in vitro system. In such embodiments, the ERED enzyme and the cofactor regeneration enzyme are synthesized in two separate cells or in a single cell. The method of the invention is then performed in vitro with the enzyme(s) provided to the reaction medium as whole cells, crude or cell free lysate, or purified recombinant protein(s), optionally immobilized, together with the cofactor, and the co-substrate. Hence a further aspect of the invention comprises a reaction medium comprising a oxidoreductase enzyme as defined herein and a compound of formula (I) and / or formula (II). The reaction medium may further comprise a cofactor regeneration system as described herein. The oxidoreductase enzyme my be provided in the form of a recombinant cell comprising the oxidoreductase enzyme, or crude or cell free lysates, or purified recombinant enzymes. Firmenich SA 16 An embodiment of the process of is wherein the cofactor regeneration system comprises an alcohol dehydrogenase, a formate dehydrogenase (FDH), or a glucose dehydrogenase (GDH) system. Where the cofactor regeneration system comprises an ADH, the cofactor regeneration system may further comprise an alcohol as a substrate for the regeneration system. Where the cofactor regeneration system comprises an GDH, the cofactor regeneration system may further comprise a glucose as a substrate for the regeneration system. Where the cofactor regeneration system comprises an FDH, the cofactor regeneration system may further comprise a formate as a substrate for the regeneration system. In some embodiments, the cofactor regenerating system may comprise a formate dehydrogenase. The terms "formate dehydrogenase" and "FDH" are used interchangeably herein to refer to an NAD+or NADP+-dependent enzyme that catalyzes the conversion of formate and NAD+or NADP+to carbon dioxide and NADH or NADPH, respectively. Formate dehydrogenases that may be suitable for use as cofactor regenerating systems in the ERED-catalyzed reduction reactions described herein include both naturally occurring formate dehydrogenases, as well as non-naturally occurring formate dehydrogenases. In a preferred embodiment of the process of the invention, the cofactor regeneration system is a formate dehydrogenase (FDH), for example LbFDH (the amino acid sequence for which is provided in SEQ ID NO: 133, the nucleotide sequences for which are provided in SEQ ID NOs: 135 and 137) and MvFDH-var (the amino acid sequence for which is provided in SEQ ID NO 134, the nucleotide sequences for which are provided in SEQ ID NOs: 136 and 138). As mentioned above, the present inventors sought to identify oxidoreductases, particularly EREDs, which be used to convert a compound of formula (I) to a compound of formula (II). Several enzymes which can be used for this purpose are shown in the accompanying examples. A further aspect of the invention is the use of a polypeptide having oxidoreductase activity comprising an amino acid sequence having least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity or more to any of SEQ ID NOs: 1 to 44 or comprising the amino acid sequence of any of SEQ ID NOs: 1 to 44 in the process of the invention for preparing a compound of formula (II). A further aspect of the invention provides an isolated polypeptide having Firmenich SA 17 oxidoreductase activity comprising an sequence having at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% or more sequence identity to any of SEQ ID NOs: 1 to 4 or comprising the amino acid sequence of any of SEQ ID NOs: 1 to 4. This is the first time a polypeptide having such an amino acid sequence has been shown to have oxidoreductase activity. Further provided herein is the use of a nucleic acid molecule encoding a polypeptide having oxidoreductase activity comprising a nucleotide sequence having at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% or more sequence identity to any of SEQ ID NOs: 45 to 132, or the reverse complement thereof, or comprising nucleotide sequence of any of SEQ ID NOs: 45 to 132, or the reverse complement thereof, in the process of the invention for preparing a compound of formula (II). A further aspect of the invention provides an isolated nucleic acid molecule encoding a polypeptide having oxidoreductase activity comprising a nucleotide sequence having at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% or more sequence identity to any of SEQ ID NOs: 45 to 48 or 89 to 92 or the reverse complement thereof, or comprising nucleotide sequence of any of SEQ ID NOs: 45 to 48 or 89 to 92, or the reverse complement thereof. This is the first time a nucleic acid sequence has been shown to encode a polypeptide having oxidoreductase activity. In one aspect provided herein is a vector comprising the nucleic acid molecules described herein. In another aspect, the vector is an expression vector. In a further aspect, the vector is a prokaryotic vector, viral vector or a eukaryotic vector. Also provided is a non-human host organism or a host cell comprising (1) a nucleic acid molecule described above, or (2) an expression vector comprising said nucleic acid molecule. In one aspect, the non-human organism or host cell is a prokaryotic or eukaryotic cell. In another aspect the host cell is a bacterial cell, a plant cell, a fungal cell or a yeast. In a further aspect, the bacterial cell is Escherichia coli and the yeast cell is Saccharomyces cerevisiae. Further provided is a nucleotide sequence obtained by modifying any of SEQ ID NOs: 45 to 132 or the reverse complement thereof which encompasses any sequence that has been obtained by modifying the sequence of any of SEQ ID NOs: 45 to 132, or of the reverse complement thereof using any method known in the art, for example, by introducing any type of mutations such as deletion, insertion and / or substitution mutations. The nucleic acids comprising a sequence obtained by mutation of any of SEQ ID NOs: 45 Firmenich SA 18 to 132 or the reverse complement thereof encompassed by an embodiment herein, provided that the sequences they comprise share at least the defined sequence identity of any of SEQ ID NOs: 45 to 132 or the reverse complement thereof and provided that they encode a polypeptide having oxidoreductase activity, as defined in any of the above embodiments. Mutations may be any kind of mutations of these nucleic acids, for example, point mutations, deletion mutations, insertion mutations and / or frame shift mutations of one or more nucleotides of the DNA sequence of any of SEQ ID NOs: 45 to 132. In one embodiment, the nucleic acid of an embodiment herein may be truncated provided that it encodes a polypeptide as described herein. A variant nucleic acid may be prepared in order to adapt its nucleotide sequence to a specific expression system. For example, bacterial expression systems are known to more efficiently express polypeptides if amino acids are encoded by particular codons. Due to the degeneracy of the genetic code, more than one codon may encode the same amino acid sequence, multiple nucleic acid sequences can code for the same protein or polypeptide, all these DNA sequences being encompassed by an embodiment herein. Where appropriate, the nucleic acid sequences encoding the oxidoreductase may be optimized for increased expression in the host cell. For example, nucleotides of an embodiment herein may be synthesized using codons particular to a host for improved expression. Provided herein are also cDNA, genomic DNA and RNA sequences. Any nucleic acid sequence encoding the oxidoreductase or variants thereof is also referred herein as an oxidoreductase encoding sequence. A fragment of a polynucleotide of any of SEQ ID NOs: 45 to 132 refers to contiguous nucleotides that is particularly at least 15 bp, at least 30 bp, at least 40 bp, at least 50 bp and / or at least 60 bp in length of the polynucleotide of an embodiment herein. Particularly the fragment of a polynucleotide comprises at least 25, more particularly at least 50, more particularly at least 75, more particularly at least 100, more particularly at least 150, more particularly at least 200, more particularly at least 300, more particularly at least 400, more particularly at least 500, more particularly at least 600, more particularly at least 700, more particularly at least 800, more particularly at least 900, more particularly at least 1000 contiguous nucleotides of the polynucleotide of an embodiment herein. Without being limited, the fragment of the polynucleotides herein may be used as a PCR primer, and / or as a probe, or for anti-sense gene silencing or RNAi. Firmenich SA 19 It is clear to the person skilled in the that genes, including the polynucleotides of an embodiment herein, can be cloned on basis of the available nucleotide sequence information, such as found in the attached sequence listing, by methods known in the art. These include e.g. the design of DNA primers representing the flanking sequences of such gene of which one is generated in sense orientations and which initiates synthesis of the sense strand and the other is created in reverse complementary fashion and generates the antisense strand. Thermostable DNA polymerases such as those used in polymerase chain reaction are commonly used to carry out such experiments. Alternatively, DNA sequences representing genes can be chemically synthesized and subsequently introduced in DNA vector molecules that can be multiplied by e.g. compatible bacteria such as e.g. E. coli. In a related embodiment provided herein, PCR primers and / or probes for detecting nucleic acid sequences encoding an oxidoreductase are provided. The skilled artisan will be aware of methods to synthesize degenerate or specific PCR primer pairs to amplify a nucleic acid sequence encoding the oxidoreductase or fragments thereof, based on any of SEQ ID NOs: 45 to 132. A detection kit for nucleic acid sequences encoding the oxidoreductase may include primers and / or probes specific for nucleic acid sequences encoding the oxidoreductase, and an associated protocol to use the primers and / or probes to detect nucleic acid sequences encoding the oxidoreductase in a sample. Such detection kits may be used to determine whether a plant, organism or cell has been modified, i.e., transformed with a sequence encoding the oxidoreductase. To test a function of variant DNA sequences according to an embodiment herein, the sequence of interest is operably linked to a selectable or screenable marker gene and expression of the reporter gene is tested in transient expression assays with protoplasts or in stably transformed plants. The skilled artisan will recognize that DNA sequences capable of driving expression are built as modules. Accordingly, expression levels from shorter DNA fragments may be different than the one from the longest fragment and may be different from each other. Provided herein are also functional equivalents of the nucleic acid sequence coding the oxidoreductase proteins provided herein, i.e., nucleotide sequences that hybridize under stringent conditions to the nucleic acid sequence of any of SEQ ID NOs: 45 to 132. The skilled artisan will be aware of methods to identify homologous sequences in other organisms and methods to determine the percentage of sequence identity between homologous sequences. Such newly identified DNA molecules then can be sequenced, and Firmenich SA 20 the sequence can be compared with the acid sequence of any of SEQ ID NOs: 45 to 132. The percentage of identity between two peptide or nucleotide sequences is a function of the number of amino acids or nucleotide residues that are identical in the two sequences when an alignment of these two sequences has been generated. Identical residues are defined as residues that are the same in the two sequences in a given position of the alignment. The percentage of sequence identity, as used herein, is calculated from the optimal alignment by taking the number of residues identical between two sequences dividing it by the total number of residues in the shortest sequence and multiplying by 100. The optimal alignment is the alignment in which the percentage of identity is the highest possible. Gaps may be introduced into one or both sequences in one or more positions of the alignment to obtain the optimal alignment. These gaps are then taken into account as non-identical residues for the calculation of the percentage of sequence identity. Alignment for the purpose of determining the percentage of amino acid or nucleic acid sequence identity can be achieved in various ways using computer programs and for instance publicly available computer programs available on the world wide web. Preferably, the BLAST program (Tatiana et al, FEMS Microbiol Lett., 1999, 174:247-250, 1999) set to the default parameters, available from the National Center for Biotechnology Information (NCBI) website at ncbi.nlm.nih.gov / BLAST / bl2seq / wblast2.cgi, can be used to obtain an optimal alignment of protein or nucleic acid sequences and to calculate the percentage of sequence identity. In one embodiment, provided herein is also an isolated, recombinant or synthetic polynucleotide encoding a polypeptide or variant polypeptide provided herein. Polypeptides are also meant to include variants and truncated polypeptides provided that they have oxidoreductase activity. According to another embodiment, the at least one polypeptide having a oxidoreductase activity used in any of the herein-described embodiments or encoded by the nucleic acid used in any of the herein-described embodiments comprises an amino acid sequence that is a variant of any of SEQ ID NOs: 1 to 44, obtained by genetic engineering, provided that said variant has oxidoreductase activity and has the required percentage of identity to any of SEQ ID NOs: 1 to 44 as described herein. According to another embodiment, the at least one polypeptide having oxidoreductase activity used in any of the herein-described embodiments or encoded by the Firmenich SA 21 nucleic acid used in any of the herein- embodiments is a variant of any of SEQ ID NOs: 1 to 44 that can be found naturally in other organisms provided that it has oxidoreductase activity. As used herein, the polypeptide includes a polypeptide or peptide fragment that encompasses the amino acid sequences identified herein, as well as truncated or variant polypeptides provided that they have oxidoreductase activity and that they share at least the defined percentage of identity with the corresponding fragment of any of SEQ ID NOs: 1 to 44. Examples of variant polypeptides are naturally occurring proteins that result from alternate mRNA splicing events or from proteolytic cleavage of the polypeptides described herein. Variations attributable to proteolysis include, for example, differences in the N- or C- termini upon expression in different types of host cells, due to proteolytic removal of one or more terminal amino acids from the polypeptides of an embodiment herein. Polypeptides encoded by a nucleic acid obtained by natural or artificial mutation of a nucleic acid of an embodiment herein, as described thereafter, are also encompassed by an embodiment herein. Polypeptide variants resulting from a fusion of additional peptide sequences at the amino and carboxyl terminal ends can also be used in the methods of an embodiment herein. In particular such a fusion can enhance expression of the polypeptides, be useful in the purification of the protein or improve the enzymatic activity of the polypeptide in a desired environment or expression system. Such additional peptide sequences may be signal peptides, for example. Another aspect encompasses methods using variant polypeptides, such as those obtained by fusion with other oligo- or polypeptides and / or those which are linked to signal peptides. Polypeptides resulting from a fusion with another functional protein can also be advantageously used in the methods of an embodiment herein. A variant may also differ from the polypeptide of an embodiment herein by attachment of modifying groups which are covalently or non-covalently linked to the polypeptide backbone. The variant also includes a polypeptide which differs from the polypeptide provided herein by introduced N-linked or O-linked glycosylation sites, and / or an addition of cysteine residues. The skilled artisan will recognize how to modify an amino acid sequence and preserve biological activity. In addition to the gene sequences shown in the sequences disclosed herein, it will be apparent for the person skilled in the art that DNA sequence polymorphisms may exist within a given population, which may lead to changes in the amino acid sequence of the Firmenich SA 22 polypeptides disclosed herein. Such polymorphisms may exist in cells from different populations or within a population due to natural allelic variation. Allelic variants may also include functional equivalents. Further embodiments also relate to the molecules derived by such sequence polymorphisms from the concretely disclosed nucleic acids. These natural variations usually bring about a variance of about 1 to 5% in the nucleotide sequence of a gene or in the amino acid sequence of the polypeptides disclosed herein. As mentioned above, the nucleic acid encoding the polypeptide or variants thereof of an embodiment herein is a useful tool to modify non-human host organisms or cells and to modify non-human host organisms or cells intended to be used in the methods described herein. An embodiment provided herein provides amino acid sequences of oxidoreductase proteins including orthologs and paralogs as well as methods for identifying and isolating orthologs and paralogs of the oxidoreductase in other organisms. The oxidoreductase polypeptide can be obtained by extraction from any organism expressing it, using standard protein or enzyme extraction technologies. If the host organism is a unicellular organism or cell releasing the polypeptide of an embodiment herein into the culture medium, the polypeptide may simply be collected from the culture medium, for example by centrifugation, optionally followed by washing steps and re- suspension in suitable buffer solutions. If the organism or cell accumulates the polypeptide within its cells, the polypeptide may be obtained by disruption or lysis of the cells and optionally further extraction of the polypeptide from the cell lysate. According to another embodiment, the at least one polypeptide having oxidoreductase can be used in the processes of the invention. The functionality or activity of any oxidoreductase protein, variant or fragment, may be determined using various methods. For example, transient or stable overexpression in plant, bacterial or yeast cells can be used to test whether the protein has activity. Oxidoreductase activity may be assessed in an assay described in the examples herein, indicating functionality. A variant or derivative of an oxidoreductase polypeptide of an embodiment herein retains an ability to have oxidoreductase activity. Amino acid sequence variants of the oxidoreductase provided herein may have additional desirable biological functions including, e.g., altered substrate utilization, reaction kinetics, product distribution or other alterations. Further provided is at least one vector comprising the nucleic acid molecules Firmenich SA 23 described herein. Also provided herein is a vector selected from the group of a prokaryotic vector, viral vector and a eukaryotic vector. Further provided here is a vector that is an expression vector. The nucleic acid sequences of an embodiment herein encoding oxidoreductase proteins can be inserted in expression vectors and / or be contained in chimeric genes inserted in expression vectors, to produce oxidoreductase proteins in a host cell or non- human host organism. The vectors for inserting transgenes into the genome of host cells are well known in the art and include plasmids, viruses, cosmids and artificial chromosomes. Binary or co-integration vectors into which a chimeric gene is inserted can also be used for transforming host cells. An embodiment provided herein provides recombinant expression vectors comprising a nucleic acid sequence of an oxidoreductase gene, or a chimeric gene comprising a nucleic acid sequence of an oxidoreductase gene, operably linked to associated nucleic acid sequences such as, for instance, promoter sequences. For example, a chimeric gene comprising a nucleic acid sequence of any of SEQ ID NO: 45 to 132 or a variant thereof may be operably linked to a promoter sequence suitable for expression in plant cells, bacterial cells or fungal cells, optionally linked to a 3’ non-translated nucleic acid sequence. Alternatively, the promoter sequence may already be present in a vector so that the nucleic acid sequence which is to be transcribed is inserted into the vector downstream of the promoter sequence. Vectors can be engineered to have an origin of replication, a multiple cloning site, and a selectable marker. In one embodiment, an expression vector comprising a nucleic acid as described herein can be used as a tool for transforming non-human host organisms or host cells suitable to carry out the method of an embodiment herein in vivo. The expression vectors provided herein may be used in the methods for preparing a genetically transformed non-human host organism and / or host cell, in non-human host organisms and / or host cells harboring the nucleic acids of an embodiment herein and in the methods for making polypeptides having oxidoreductase activity, as described herein. Recombinant non-human host organisms and host cells transformed to harbor at least one nucleic acid of an embodiment herein so that it heterologously expresses or over- expresses at least one polypeptide of an embodiment herein are also very useful tools to Firmenich SA 24 carry out the method of an embodiment Such non-human host organisms and host cells are therefore provided herein. Accordingly, a further aspect of the invention provides a recombinant cell comprising a compound of formula (I) and / or formula (II) and an oxidoreductase. In one embodiment is provided a host cell or non-human host organism comprising at least one of the nucleic acid molecules described herein or comprising at least one vector comprising at least one of the nucleic acid molecules. A nucleic acid according to any of the above-described embodiments can be used to transform the non-human host organisms and cells and the expressed polypeptide can be any of the above-described polypeptides. In one embodiment, the non-human host organism or host cell is a prokaryotic cell. In another embodiment, the non-human host organism or host cell is a bacterial cell. In a further embodiment, the non-human host organism or host cell is Escherichia coli. In one embodiment, the non-human host organism or host cell is a eukaryotic cell. In another embodiment, the non-human host organism or host cell is a yeast cell. In a further embodiment, the non-human host organism or cell is Saccharomyces cerevisiae. In one embodiment the non-human host organism or host cell expresses a polypeptide, provided that the organism or cell is transformed to harbor a nucleic acid encoding said polypeptide, this nucleic acid is transcribed to mRNA and the polypeptide is found in the host organism or cell. Suitable methods to transform a non-human host organism or a host cell have been previously described and are also provided herein. To carry out an embodiment herein in vivo, the host organism or host cell is cultivated under conditions conducive to the production of a compound of formula (II). If the host is a unicellular organism, conditions conducive to the production of a compound of formula (II) may comprise addition of suitable cofactors to the culture medium of the host. In addition, a culture medium may be selected, so as to maximize compound of formula (II) synthesis. Examples of optimal culture conditions are described in a more detailed manner in the examples. Non-human host organisms suitable to carry out the method of an embodiment herein in vivo may be any non-human multicellular or unicellular organisms. In one embodiment, the non-human host organism used to carry out an embodiment herein in vivo is a plant, a prokaryote or a fungus. Any plant, prokaryote or fungus can be used. In another Firmenich SA 25 embodiment the non-human host organism to carry out the method of an embodiment herein in vivo is a microorganism. Any microorganism can be used, for example, the microorganism can be a bacteria or yeast, such as Escherichia coli or Saccharomyces cerevisiae. Isolated higher eukaryotic cells can also be used, instead of complete organisms, as hosts to carry out the method of an embodiment herein in vivo. Suitable eukaryotic cells may be any non-human cell, such as plant or fungal cells. Further provided here is a method comprising transforming a host cell or a non- human host organism with a nucleic acid encoding a polypeptide having oxidoreductase activity and comprising an amino acid sequence having at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to any of SEQ ID NOs: 45 to 132, preferably 45 to 48 or 89 to 92, or comprising the nucleic acid sequence of any of SEQ ID NOs: 45 to 132, preferably 45 to 48 or 89 to 92. In one embodiment, a method provided herein comprises cultivating a non-human host organism or a host cell transformed to express a polypeptide wherein the polypeptide comprises a sequence of amino acids that has at least 75%, 80%, 85%, 90%, 95%, 98%, 99% or 100% sequence identity to any of SEQ ID NOs: 1 to 44, preferably 1 to 4, under conditions that allow for the production of the polypeptide. It is well known in the art that aldehydes can be reduced by endogenous ketoreductases present in host strains such as E. coli and yeasts, causing unwanted reduction of substrate or product of the process of the invention to the respective alcohol during in vivo and in vitro production processes. Such ketoreductases can be downregulated, engineered or removed so as to improve the efficiency of the process of the invention. Examples of such ketoreductases include: ADH6 and ADH7 in yeast, yahK, dkgA. dkgB, yeaE, yjgB, yqhD, ybbO, yghZ, adhE, entA, gldA, fucO, eutG, adhP, yghAyiaY, ydjL, ydjJ, ybdR, yphC or betA. Multiple ketoreductases can be targeted at the same time. Hence an embodiment of the process of the invention is wherein the host cells has reduced expression (and even no expression) of one or more endogenous ketoreductases, preferably the ketoreductase is selected from: ADH6 and ADH7 in yeast, yahK, dkgA. dkgB, yeaE, yjgB, yqhD, ybbO, yghZ, adhE, entA, gldA, fucO, eutG, adhP, yghAyiaY, ydjL, ydjJ, ybdR, yphC or betA. The invention further relates to methods for recombinant production of polypeptides according to the invention or functional, biologically active fragments thereof, wherein a Firmenich SA 26 polypeptide-producing microorganism is optionally the expression of the polypeptides is induced by applying at least one inducer inducing gene expression and the expressed polypeptides are isolated from the culture. The polypeptides can also be produced in this way on an industrial scale, if desired. The microorganisms produced according to the invention can be cultured continuously or discontinuously in the batch method or in the fed-batch method or repeated fed-batch method. A summary of known cultivation methods can be found in the textbook by Chmiel (Bioprozesstechnik 1. Einführung in die Bioverfahrenstechnik [Bioprocess technology 1. Introduction to bioprocess technology] (Gustav Fischer Verlag, Stuttgart, 1991)) or in the textbook by Storhas (Bioreaktoren and periphere Einrichtungen [Bioreactors and peripheral equipment] (Vieweg Verlag, Braunschweig / Wiesbaden, 1994)) The culture medium to be used must suitably meet the requirements of the respective strains. Descriptions of culture media for various microorganisms are given in the manual “Manual of Methods for General Bacteriology” of the American Society for Bacteriology (Washington D. C., USA, 1981). These media usable according to the invention usually comprise one or more carbon sources, nitrogen sources, inorganic salts, vitamins and / or trace elements. Preferred carbon sources are sugars, such as mono-, di- or polysaccharides. Very good carbon sources are for example glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose. Sugars can also be added to the media via complex compounds, such as molasses, or other by-products of sugar refining. It can also be advantageous to add mixtures of different carbon sources. Other possible carbon sources are oils and fats, for example soybean oil, sunflower oil, peanut oil and coconut oil, fatty acids, for example palmitic acid, stearic acid or linoleic acid, alcohols, for example glycerol, methanol or ethanol and organic acids, for example acetic acid or lactic acid. Nitrogen sources are usually organic or inorganic nitrogen compounds or materials that contain these compounds. Examples of nitrogen sources comprise ammonia gas or ammonium salts, such as ammonium sulfate, ammonium chloride, ammonium phosphate, ammonium carbonate or ammonium nitrate, nitrates, urea, amino acids or complex nitrogen sources, such as corn-steep liquor, soya flour, soya protein, yeast extract, meat extract and others. The nitrogen sources can be used alone or as a mixture. Inorganic salt compounds that can be present in the media comprise the chloride, Firmenich SA 27 phosphorus or sulfate salts of calcium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron. Inorganic sulfur-containing compounds, for example sulfates, sulfites, dithionites, tetrathionates, thiosulfates, sulfides, as well as organic sulfur compounds, such as mercaptans and thiols, can be used as the sulfur source. Phosphoric acid, potassium dihydrogen phosphate or dipotassium hydrogen phosphate or the corresponding sodium-containing salts can be used as the phosphorus source. Chelating agents can be added to the medium, in order to keep the metal ions in solution. Especially suitable chelating agents comprise dihydroxyphenols, such as catechol or protocatechuate, or organic acids, such as citric acid or aminopolycarboxylic acids, such as ethylenediaminetetraacetic acid (EDTA). The fermentation media used according to the invention usually also contain other growth factors, such as vitamins or growth promoters, which include for example biotin, riboflavin, thiamine, folic acid, nicotinic acid, pantothenate and pyridoxine, or cofactors such as, flavin mononucleotide and flavin-adenine dinucleotide. Growth factors and salts often originate from the components of complex media, such as yeast extract, molasses, corn-steep liquor and the like. Moreover, suitable precursors can be added to the culture medium. The exact composition of the compounds in the medium is strongly dependent on the respective experiment and is decided for each specific case individually. Information on media optimization can be found in the textbook “Applied Microbiol. Physiology, A Practical Approach” (Ed. P. M. Rhodes, P. F. Stanbury, IRL Press (1997) p. 53-73, ISBN 0199635773). Growth media can also be obtained from commercial suppliers, such as Standard 1 (Merck) or BHI (brain heart infusion, DIFCO) and the like. All components of the medium are sterilized, either by heat (20 min at 1.5 bar and 121° C.) or by sterile filtration. The components can either be sterilized together, or separately if necessary. All components of the medium can be present at the start of culture or can be added either continuously or batchwise. The culture temperature is normally between 15°C and 45°C, preferably 25°C to 40°C and can be varied or kept constant during the experiment. The pH of the medium should be in the range from 5 to 8.5, preferably around 7.0. The pH for growing can be controlled during growing by adding basic compounds such as sodium hydroxide, potassium hydroxide, ammonia or ammonia water or acid compounds such as phosphoric Firmenich SA 28 acid or sulfuric acid. Antifoaming agents, example fatty acid polyglycol esters, can be used for controlling foaming. To maintain the stability of plasmids, suitable selective substances, for example antibiotics, can be added to the medium. To maintain aerobic conditions, oxygen or oxygen-containing gas mixtures, for example ambient air, are fed into the culture. The culture is continued until a maximum of the desired product has formed. This target is normally reached within 10 hours to 160 hours. The fermentation broth is then processed further. Depending on requirements, the biomass can be removed from the fermentation broth completely or partially by separation techniques, for example centrifugation, filtration, decanting or a combination of these methods or can be left in it completely. If the polypeptides are not secreted in the culture medium, the cells can also be lysed and the product can be obtained from the lysate by known methods for isolation of proteins. The cells can optionally be disrupted with high-frequency ultrasound, high pressure, for example in a French press, by osmolysis, by the action of detergents, lytic enzymes or organic solvents, by means of homogenizers or by a combination of several of the aforementioned methods. The polypeptides can be purified by known chromatographic techniques, such as molecular sieve chromatography (gel filtration), such as Q-sepharose chromatography, ion exchange chromatography, affinity chromatography and hydrophobic chromatography, and with other usual techniques such as ultrafiltration, crystallization, salting-out, dialysis and native gel electrophoresis. Suitable methods are described, for example in Cooper, T. G., Biochemische Arbeitsmethoden [Biochemical processes], Verlag Walter de Gruyter, Berlin, N.Y. or in Scopes, R., Protein Purification, Springer Verlag, New York, Heidelberg, Berlin. For isolating the recombinant protein, it can be advantageous to use vector systems or oligonucleotides, which lengthen the cDNA by defined nucleotide sequences and therefore code for altered polypeptides or fusion proteins, which for example serve for easier purification. Suitable modifications of this type are for example so-called “tags” functioning as anchors, for example the modification known as hexa-histidine anchor or epitopes that can be recognized as antigens of antibodies (described for example in Harlow, E. and Lane, D., 1988, Antibodies: A Laboratory Manual. Cold Spring Harbor (N.Y.) Press). These anchors can serve for attaching the proteins to a solid carrier, for example a polymer matrix, which can for example be used as packing in a chromatography column, Firmenich SA 29 or can be used on a microtiter plate or on other carrier. The enzymes or polypeptides according to the invention or for use in the processes of the invention can be used free or immobilized in the method described herein. An immobilized enzyme is an enzyme that is fixed to an inert carrier. Suitable carrier materials include for example clays, clay minerals, such as kaolinite, diatomaceous earth, perlite, silica, aluminum oxide, sodium carbonate, calcium carbonate, cellulose powder, anion and cation exchanger materials, synthetic polymers, such as polystyrene, acrylic resins, phenol formaldehyde resins, polyurethanes and polyolefins, such as polyethylene and polypropylene. For making the supported enzymes, the carrier materials are usually employed in a finely divided, particulate form, porous forms being preferred. The particle size of the carrier material is usually not more than 5 mm, in particular not more than 2 mm (particle-size distribution curve). Similarly, when using whole-cells as catalyst, a carrier- free or immobilized form can be selected. Carrier materials are e.g. Ca-alginate, and carrageenan. Enzymes as well as cells can also be crosslinked directly with glutaraldehyde (cross-linking to CLEAs). Corresponding and other immobilization techniques are described for example in J. Lalonde and A. Margolin “Immobilization of Enzymes” in K. Drauz and H. Waldmann, Enzyme Catalysis in Organic Synthesis 2002, Vol. III, 991-1032, Wiley-VCH, Weinheim. Further information on biotransformations and bioreactors for carrying out methods according to the invention are also given for example in Rehm et al. (Ed.) Biotechnology, 2nd Edn, Vol 3, Chapter 17, VCH, Weinheim. The at least one oxidoreductase enzyme which is present during a process of the invention or an individual step of a multistep-method as defined herein, can be present in living cells naturally or recombinantly producing the enzyme or enzymes, in harvested cells, in dead cells, in permeabilized cells, in crude cell extracts, in purified extracts, or in essentially pure or completely pure form. The at least one enzyme may be present in solution or as an enzyme immobilized on a carrier or encapsulated. One or several enzymes may simultaneously be present in soluble and / or immobilized form. Also included in the scope of the present invention is the use of various commercially available laboratory kits. These kits can include reagents, including ERED enzymes which can be used in the process of the invention. Also included in the scope of the invention is wherein the ERED enzyme is purchased from suppliers of laboratory reagents and / or enzymes. Such kits and enzyme suppliers are well known the skilled person. Firmenich SA 30 The processes according to the can be performed in common reactors, which are known to those skilled in the art, and in different ranges of scale, e.g. from a laboratory scale (few milliliters to dozens of liters of reaction volume) to an industrial scale (several liters to thousands of cubic meters of reaction volume). If the enzyme is used in a form encapsulated by non-living, optionally permeabilized cells, in the form of a more or less purified cell extract or in purified form, a chemical reactor can be used. The chemical reactor usually allows controlling the amount of the at least one enzyme, the amount of the at least one substrate, the pH, the temperature and the circulation of the reaction medium. When the at least one polypeptide / enzyme is present in living cells, the process will be a fermentation. In this case the biocatalytic production will take place in a bioreactor (fermenter), where parameters necessary for suitable living conditions for the living cells (e.g. culture medium with nutrients, temperature, aeration, presence or absence of oxygen or other gases, antibiotics, and the like) can be controlled. Those skilled in the art are familiar with chemical reactors or bioreactors, e.g. with procedures for up-scaling chemical or biotechnological methods from laboratory scale to industrial scale, or for optimizing process parameters, which are also extensively described in the literature (for biotechnological methods see e.g. Crueger und Crueger, Biotechnologie – Lehrbuch der angewandten Mikrobiologie, 2. Ed., R. Oldenbourg Verlag, München, Wien, 1984). Cells containing the at least one enzyme can be permeabilized by physical or mechanical means, such as ultrasound or radiofrequency pulses, French presses, or chemical means, such as hypotonic media, lytic enzymes and detergents present in the medium, or combination of such methods. Examples for detergents are digitonin, n- dodecylmaltoside, octylglycoside, Triton® X-100, Tween® 20, deoxycholate, CHAPS (3- [(3-Cholamidopropyl)dimethylammonio]-1-propansulfonate), Nonidet® P40 (Ethylphenolpoly(ethyleneglycolether), and the like. Instead of living cells biomass of non-living cells containing the required biocatalyst(s) may be applied for the biotransformation reactions of the invention as well. If the at least one enzyme is immobilized, it can be attached to an inert carrier as described above. The conversion reaction can be carried out batch wise, fed-batch, semi-batch wise or continuously. Reactants (and optionally nutrients) can be supplied at the start of reaction or can be supplied subsequently, either semi-continuously or continuously. The reaction of the invention, depending on the particular reaction type, may be Firmenich SA 31 performed in an aqueous, aqueous-organic non-aqueous reaction medium. An aqueous or aqueous-organic medium may contain a suitable buffer in order to adjust the pH to a value in the range of 5 to 11, like 6 to 10. In an aqueous-organic medium an organic solvent miscible, partly miscible or immiscible with water may be applied. Non-limiting examples of suitable organic solvents might be selected from aliphatic hydrocarbons having for example 5 to 8 carbon atoms, like pentane, cyclopentane, hexane, cyclohexane, heptane, octane or cyclooctane, chlorinated hydrocarbons, aromatic hydrocarbons like benzene, toluene, xylenes, chlorobenzene or dichlorobenzene, esters, such as ethylacetate, isopropylmyristate, ethers, like diethylether, methyl-tert.-butylether, ethyl-tert.-butylether, dipropylether, diisopropylether, dibutylether, tetrahydrofuran or 2-methyltetrahydrofuran, ketones and alcohols. Additional mediums include DMF, DMSO, deep eutectic solvent or ionic liquids. Further examples are mono- or polyhydric, aromatic or aliphatic alcohols, in particular polyhydric aliphatic alcohols like glycerol. The ratio between aqueous and organic phase in a biphasic reaction system with water immiscible organic solvents may be 20:1 to 1:10, preferably 10:1 to 1:1, more preferably 8:2 to 8:1.8. The non-aqueous medium may be substantially free of water, i.e. may contain less that about 1 wt.-% or 0.5 wt.-% of water. Biocatalytic methods may also be performed in an organic non-aqueous medium. A suitable organic solvents might be selected from aliphatic hydrocarbons having for example 5 to 8 carbon atoms, like pentane, cyclopentane, hexane, cyclohexane, heptane, octane or cyclooctane, chlorinated hydrocarbons, aromatic hydrocarbons like benzene, toluene, xylenes, chlorobenzene or dichlorobenzene, esters, such as ethylacetate, isopropylmyristate, ethers, like diethylether, methyl-tert.-butylether, ethyl-tert.-butylether, dipropylether, diisopropylether, dibutylether, tetrahydrofuran or 2-methyltetrahydrofuran, ketones and alcohols. Additional mediums include DMF, DMSO, deep eutectic solvent or ionic liquids. The concentration of the reactants / substrates may be adapted to the optimum reaction conditions, which may depend on the specific enzyme applied. For example, the initial substrate concentration may be in the 0.001 to 1 M, preferably 0.01 to 0.5 M, preferably 0.05 to 0.2 M, preferably 0.1 to 0.2 M, Cofactors, such as NADP+, NAD+, NADH, NADPH, or FMN and FAD may be Firmenich SA 32 added to the reaction medium. The of such cofactors may depend on the specific enzyme applied. For example, the concentration of cofactors such as NADP+, NAD+, NADH, NADPH may be 0.1 to 1.5 mM, preferably, 0.2 to 1 mM, and the concentration of cofactors such as FMN and FAD may be 0.5 to 50 µM, preferably 1 to 5 µM. The reaction temperature may be adapted to the optimum reaction conditions, which may depend on the specific enzyme applied. For example, the reaction may be performed at a temperature in a range of from 0 to 70°C, as for example 20 to 50 or 25 to 40°C. Examples for reaction temperatures are about 25°C, 28°C, 30°C, about 35°C, about 37°C, about 40°C, about 45°C, about 50°C, about 55°C and about 60°C. The process may proceed until equilibrium between the substrate and the product(s) is achieved but may be stopped earlier. Usual process times are in the range from 10 minutes to 48 hours, in particular 5 hours to 40 hours, as for example in the range from 10 hour to 30 hours, most preferably approximately 24 hours. These parameters are non-limiting examples of suitable process conditions. The methodology of the present invention can further include a step of recovering an end or intermediate product, optionally in stereoisomerically or enantiomerically substantially pure form. The term “recovering” includes extracting, harvesting, isolating or purifying the compound from culture or reaction media. Recovering the compound can be performed according to any conventional isolation or purification methodology known in the art including, but not limited to, treatment with a conventional resin (e.g., anion or cation exchange resin, non-ionic adsorption resin, etc.), treatment with a conventional adsorbent (e.g., activated charcoal, silicic acid, silica gel, cellulose, alumina, etc.), alteration of pH, solvent extraction (e.g., with a conventional solvent such as an alcohol, ethyl acetate, hexane and the like), distillation, dialysis, filtration, concentration, crystallization, recrystallization, pH adjustment, lyophilization and the like. As discussed herein, the present inventors were able for the first time to use oxidoreductases in a process for the preparation of a compound of formula (II). Hence until the present invention a cell culture fermentation comprising a recombinant cell of the invention and a compound of formula (I) was not known in the art. A further aspect of the invention provides a cell culture media comprising the recombinant cell comprising an oxidoreductase, preferably an ERED, and a compound of formula (I) and / or formula (II). The composition of such media has been disclosed above in relation to the performance of Firmenich SA 33 the process of the invention. Identity and purity of the isolated product may be determined by known techniques, like High Performance Liquid Chromatography (HPLC), gas chromatography (GC), Spectroscopy (like IR, UV, NMR), Coloring methods, TLC, NIRS, enzymatic or microbial assays. (see for example: Patek et al. (1994) Appl. Environ. Microbiol. 60:133-140; Malakhova et al. (1996) Biotekhnologiya 1127-32; und Schmidt et al. (1998) Bioprocess Engineer. 19:67-70. Ullmann's Encyclopedia of Industrial Chemistry (1996) Bd. A27, VCH: Weinheim, S. 89-90, S.521-540, S.540-547, S. 559-566, 575-581 und S.581-587; Michal, G (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; Fallon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, Bd.17.) Another object of the present invention is a process for the preparation of a compound of formula in the form of thereof, and wherein each R1, R2and R3, independently from each other, represent a hydrogen atom, a C1-3alkoxy group, a C1-6alkyl group or a C2-6alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8cycloalkyl or C5-8cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; comprising the steps of a) converting a compound of formula Firmenich SA 34 in the form of any one of their or a mixture thereof, and wherein R1, R2, R3,R4and R5have the same meaning as defined in formula (I); into an acetal of formula thereof, and wherein R1, R2, R3, R4and R5have the same meaning as defined in formula (I); Raand Rb, independently from each other, represent a C1-4alkyl group or Raand Rb, when taken together, represent a C2-5 alkanediyl group; b) treating the acetal obtained in step a) with an acid and a compound of formula R6-CH=CH-ORc; wherein R6has the same meaning as defined in formula (I) and Rcrepresents a C1-4alkyl group; to obtain a compound of formula in the form of any one1 2 3 and wherein R , R , R,R4, R5, R6, Ra, Rband Rchave the same meaning as defined above; and c) treating the compound of formula (V) with an acid to obtain a compound of formula (I). According to any embodiment of the invention, Raand Rb, independently from each other, may be a C1-3 alkyl group. Particularly, Raand Rb, independently from each other, may be a methyl or ethyl group. Even more particularly, Raand Rb, independently from each other, may be a methyl group. According to any embodiment of the invention, Rcmay be a C1-3alkyl group. Particularly, Rcmay be a methyl or ethyl group. Even more particularly, Rcis an ethyl group. Firmenich SA 35 According to any embodiments of invention, the conversion of the compound of formula (III) into acetal of formula (IV) may be carried out under normal conditions known by the person skilled in the art, i.e. in the presence of an acid such as Bronsted acid or a Lewis acid compatible with alcohols, such as Lanthanide triflates, and a reagent selected from the group consisting of C1-4 trialkyl orthoformate, C1-4 alcohol, C2-5 diol and a mixture thereof. The conversion of aldehyde derivatives into the corresponding acetals is well known and has been largely reported in the prior art. So, the person skilled in the art will be able to set up the best conditions in order to convert compound of formula (III) into compound of formula (IV). As non-limiting example, the step a) may be performed under the conditions reported in Green Chemistry, 2013, 15(10), 2740-2746; Synthesis, 2009, (23), 4082-4086; Synlett, 2002, (2), 319-321; Tetrahedron Letters, 2004, 45(26), 5135- 5138; Current Organocatalysis, 2018, 5(3), 196-200 or Tetrahedron Letters, 2004, 45(44), 8141-8144. According to a particular embodiment of the invention, the acid used in step a) may have a pKa below 3. Specific and non-limiting examples of Bronsted acid may be selected from the group consisting of para toluenesulfonic acid, methanesulfonic acid, camphorsulfonic acid, methanedisulfonic acid, methanetrisulfonic acid, 2,4 dinitrobenzenesulfonic acid. Particularly, the Bronsted acid may be para-toluenesulfonic acid. Specific and non-limiting examples of Lewis acid compatible with alcohols may be selected from the group consisting of metal triflates such as Al(OTf)3, Lanthanide triflates such as Sc(OTf)3, Bi(OTf)3, metal tetrafluoroborates such as Zn(BF4)2, and zinc halides such as ZnCl2, ZnBr2. Specific and non-limiting examples of C1-4 trialkyl orthoformate, C1-4alcohol or C2-5diol may be selected from the group consisting of methanol, ethanol, ethylene glycol, propylene glycol, trimethyl orthoformate, triethyl orthoformate. The C1-4trialkyl orthoformate, C1-4alcohol or C2-5diol can be added into the reaction medium of the invention’s process in a large range of concentrations. As non- limiting examples, one can cite as C1-4trialkyl orthoformate or C2-5diol concentration values those ranging from about 1 to about 2 equivalents, relative to the amount of the of substrate, preferably from 1 to about 1.5 equivalents, relative to the amount of the of substrate. As non-limiting examples, one can cite as C1-4 alcohol concentration values those ranging from about 2 to about 15 equivalents, relative to the amount of the of substrate, preferably from 3 to about 5 equivalents, relative to the amount of the of substrate The optimum concentration of the C1-4trialkyl orthoformate, C1-4alcohol or C2-5diol will Firmenich SA 36 depend, as the person skilled in the art on the nature of the latter, on the nature of the substrate, on the reaction temperature as well as on the desired time of reaction. The acid of step a) can be added into the reaction medium of the invention’s process in a large range of concentrations. As non-limiting examples, one can cite as acid concentration values those ranging from about 0.1 to about 5 mol%, relative to the amount of the of substrate, preferably from 0.3 to about 3 mol%, relative to the amount of the of substrate, more preferably from 0.3 to about 1 mol%, relative to the amount of the of substrate, The optimum concentration of the acid of step a) will depend, as the person skilled in the art knows, on the nature of the latter, on the nature of the substrate, on the nature of the C1-4trialkyl orthoformate, C1-4alcohol or C2-5diol, on the reaction temperature as well as on the desired time of reaction. According to any one of the invention’s embodiments, the invention’s process to form compound of formula (IV) is carried out at a temperature comprised between 20°C and 55°C. In particular, the temperature is in the range between 20°C and 30°C. Of course, a person skilled in the art is also able to select the preferred temperature as a function of the melting and boiling point of the starting and final products as well as the desired time of reaction or conversion. The acetal formation can be carried out in the presence or absence of a solvent. When a solvent is required or used for practical reasons, then any solvent current in such reaction type can be used for the purposes of the invention. Non-limiting examples include C6-12 aromatic solvents such as toluene, 1,3-diisopropylbenzene, cumene or pseudocumene, or mixtures thereof, alcoholic solvent such as methanol, ethanol, or mixtures thereof, hydrocarbon solvents such as cyclohexane or heptane, ethyl acetate or ethereal solvents such as methyl tetrahydrofuran, tetrahydrofuran or mixtures thereof. The choice of the solvent is function of the nature of the substrate and / or catalyst and the person skilled in the art is well able to select the solvent most suitable in each case to optimize the reaction. According to any embodiments of the invention, the treatment of the acetal of formula (IV) may be carried with a compound of formula R6-CH=CH-ORc; wherein Rcand R6has the same meaning as defined above. Specific and non-limiting examples of acid used in step b) may be selected from the group consisting of Boron trifluoride complexes, such as BF3.OEt2, BF3.OBu2, BF3.(AcOH)2 or BF3.MeCN, anhydrous zinc chloride, para toluene sulfonic acid. Particularly, the acid use is step b) is a Lewis acid. Firmenich SA 37 The compound of formula R6- ORccan be added into the reaction medium of the invention’s process in a large range of concentrations. As non-limiting examples, one can cite as enol ether concentration values those ranging from about 1 to about 5 equivalents, relative to the amount of the substrate, preferably from 1.0 to about 1.2 equivalents, relative to the amount of the of substrate The optimum concentration of the compound of formula R6-CH=CH-ORcwill depend, as the person skilled in the art knows, on the nature of the latter, on the nature of the substrate, on the reaction temperature as well as on the desired time of reaction. The acid used in step b) can be added into the reaction medium of the invention’s process in a large range of concentrations. As non-limiting examples, one can cite as acid concentration values those ranging from about 0.001 mol% to about 10 mol%, relative to the amount of the of substrate, preferably from 0.01 mol% to about 5 mol%, relative to the amount of the of substrate The optimum concentration of the acid used in step b) will depend, as the person skilled in the art knows, on the nature of the latter, on the nature of the substrate, on the reaction temperature as well as on the desired time of reaction. According to any one of the invention’s embodiments, the invention’s process to form compound of formula (V) is carried out at a temperature comprised between 10°C and 100°C. In particular, the temperature is in the range between 5°C and 25°C. Of course, a person skilled in the art is also able to select the preferred temperature as a function of the melting and boiling point of the starting and final products as well as the desired time of reaction or conversion. The step b) of the invention’s process can be carried out in the presence or absence of a solvent. When a solvent is required or used for practical reasons, then any solvent current in such reaction type can be used for the purposes of the invention. Non-limiting examples include C6-12 aromatic solvents such as toluene, 1,3-diisopropylbenzene, cumene or pseudocumene, or mixtures thereof, ethyl acetate or ethereal solvents such as methyl tetrahydrofuran, tetrahydrofuran or mixtures thereof or chlorinated solvents such dichloromethane, dichloroethane or a mixture thereof. The choice of the solvent is function of the nature of the substrate and / or catalyst and the person skilled in the art is well able to select the solvent most suitable in each case to optimize the reaction. Particularly, the step b) may be carried out in absence of solvent. According to any one of the invention’s embodiments, steps a) and b) of the invention’s process may be done in one pot with an acid such as boron trifluoride acetic Firmenich SA 38 acid complex, para toluene sulfonic acid, sulfonic acid. According to any one of the invention’s embodiments, the acid used in step c) may be selected from the group consisting of carboxyl acid such as formic, acetic acid, aqueous acetic acid or propionic acid, inorganic acid such aqueous sulfuric acid, sulfuric acid, aqueous hydrochloric acid. Particularly, the acid used in step c) may be acetic acid. The acid used in step c) can be added into the reaction medium of the invention’s process in a large range of concentrations. As non-limiting examples, one can cite as acid concentration values those ranging from about 1 to about 10 equivalents, relative to the amount of the of substrate, preferably from 3 to about 8 equivalents, relative to the amount of the of substrate The optimum concentration of the acid used in step c) will depend, as the person skilled in the art knows, on the nature of the latter, on the nature of the substrate, on the reaction temperature as well as on the desired time of reaction. According to any one of the invention’s embodiments, the step c) may be carried out in a presence of a base in addition to the acid. Non-limiting example of base selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium acetate, potassium acetate, sodium formate, potassium formate, sodium propionate and potassium propionate. Particularly, the base further added in step c) may be sodium acetate. The base used in step c) can be added into the reaction medium of the invention’s process in a large range of concentrations. As non-limiting examples, one can cite as base concentration values those ranging from about 1 to about 5 equivalents, relative to the amount of the of substrate, preferably from 1 to about 2 equivalents, relative to the amount of the of substrate The optimum concentration of the base used in step c) will depend, as the person skilled in the art knows, on the nature of the latter, on the nature of the substrate, on the nature of the acid on the reaction temperature as well as on the desired time of reaction. According to any one of the invention’s embodiments, the invention’s process to form compound of formula (I) is carried out at a temperature comprised between 25°C and 150°C. In particular, the temperature is in the range between 90°C and 120°C. Of course, a person skilled in the art is also able to select the preferred temperature as a function of the melting and boiling point of the starting and final products as well as the desired time of reaction or conversion. The step c) can be carried out in the presence or absence of a solvent. When a solvent is required or used for practical reasons, then any solvent current in such reaction type can Firmenich SA 39 be used for the purposes of the invention. limiting examples include C6-12 aromatic solvents such as toluene, 1,3-diisopropylbenzene, cumene or pseudocumene, or mixtures thereof, alcoholic solvent such as methanol, ethanol, or mixtures thereof, hydrocarbon solvents such as but not limited to, cyclohexane or heptane, ethyl acetate or ethereal solvents such as methyl tetrahydrofuran, tetrahydrofuran, 1,4-dioxane or mixtures thereof. The choice of the solvent is function of the nature of the substrate and / or catalyst and the person skilled in the art is well able to select the solvent most suitable in each case to optimize the reaction. According to any embodiment of the invention, the invention’s process may be carried out in one pot; i.e. step a) to c) may be performed without isolation step of any intermediate. According to any embodiment of the invention, the invention’s process for the preparation of compound of formula (I) may be carried out under batch or continuous conditions. The compound of formula (IV) and (V) are, generally, novel compounds and present a number of advantages as explained above and shown in the Examples. Therefore, another object of the present invention is a compound of formula in the form of any one and wh1 2 erein R , R and R3, independently from each other, represent a hydrogen atom, a C1-3 alkoxy group, a C1-6 alkyl group or a C2-6 alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8 cycloalkyl or C5-8 cycloalkenyl group; R4and R5, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4 alkyl group or Raand Rb, when taken together, represent a C2-5alkanediyl group. Another object of the present invention is a compound of formula Firmenich SA 40 in the form of and wherei1 2 n R , R and R3, independently from each other, represent a hydrogen atom, a C1-3 alkoxy group, a C1-6alkyl group or a C2-6alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8 cycloalkyl or C5-8cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4alkyl group or Raand Rb, when taken together, represent a C2-5 alkanediyl group; Rcrepresents a C1-4 alkyl group. Another object of the present invention is the use of a compound of formula in the form of any1 2 and wherein R , R and R3, independently from each other, represent a hydrogen atom, a C1-3alkoxy group, a C1-6 alkyl group or a C2-6 alkenyl group, each optionally substituted by a hydroxy or C1-3alkoxy group; or or R1and R2, are taken together and form a C3-8cycloalkyl or C5-8 cycloalkenyl group; R4and R5, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4alkyl group or Raand Rb, when taken together, represent a C2-5 alkanediyl group; in the process for preparing compounds of formula (I) and (II). Another object of the present invention is the use of a compound of formula Firmenich SA 41 in the form of and and wherein R1, R2and R3, independently from each other, represent a hydrogen atom, a C1-3 alkoxy group, a C1-6alkyl group or a C2-6alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3- 8 cycloalkyl or C5-8cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4alkyl group or Raand Rb, when taken together, represent a C2-5 alkanediyl group; Rcrepresents a C1-4 alkyl group; in the process for preparing compounds of formula (I) and (II). Typical manners to execute the invention’s process are reported herein below in the examples.

[0002] Firmenich SA 42 Examples The invention will now be described in further detail by way of the following examples, wherein the abbreviations have the usual meaning in the art, the temperatures are indicated in degrees centigrade (°C). NMR spectra were acquired using either a Bruker Avance II Ultrashield 400 plus operating at 400 MHz, (1H) and 100 MHz (13C) or a Bruker Avance III 500 operating at 500 MHz (1H) and 125 MHz (13C) or a Bruker Avance III 600 cryoprobe operating at 600 MHz (1H) and 150 MHz (13C). Spectra were internally referenced relative to tetramethyl silane 0.0 ppm.1H NMR signal shifts are expressed in δ ppm, coupling constants (J) are expressed in Hz with the following multiplicities: s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet; b, broad (indicating unresolved couplings) and were interpreted using Bruker Topspin software.13C NMR data are expressed in chemical shift δ ppm and hybridization from DEPT 90 and DEPT 135 experiments, C, quaternary; CH, methine; CH2, methylene; CH3, methyl. Example 1 Preparation of (2E,4E)-4-Methyl-5-(4-methylphenyl)-2,4-pentanedienal (compound of formula (I) according to the invention process a) Step 1: Preparation of (2E)-2-Methyl-3-(4-methylphenyl)-2-propenal (Compound of formula (III)) A mixture of potassium hydroxide (65.2 g, 1.16 mol.), methanol (1250 g) and p- tolualdehyde (2000.0 g, 16.7 mol.) was heated to 45°C. Propionaldehyde (1051 g, 18.1 mol.) was added in 2 hours. 30 minutes after the end of the addition, propionic acid (49.2 g, 0.664 mol) was added and the mixture was concentrated by distillation. The mixture was cooled to 45°C and water (400.0 g) and heptane (1335.0 g) were added under stirring. The mixture was allowed to settle. The aqueous phase was decanted and discarded. The organic phase was washed with water (200.0 g) and concentrated by distillation. Crude product (2673.8 g, purity: 84.1% GC, orange liquid) was used as such for the next step. b) Step 2: Preparation of 1-[(1E)-3,3-Dimethoxy-2-methyl-1-propenyl]-4- methylbenzene (Compound of formula (IV) A mixture of the crude product from Step 1 (2673.8 g, 16.67 mol.), p-toluenesulfonic acid (27.0 g, 0.142 mol.) and methanol (670 g) was heated to 30°C. Methyl orthoformate (1948.0 Firmenich SA 43 g, 18.36 mol.) was added over 2 hours. 15 after the end of the addition, sodium methylate (30% solution in methanol, 33.4 g, 0.185 mol.) was added and the mixture was concentrated by distillation. Crude acetal (3507.1 g, purity 90.8% GC, dark brown liquid) was flash-distilled (eb.: 52-126°C, p=40-1 mbar) affording a light-yellow liquid (2914.1 g, purity: 93.1%). The product was further purified by distillation through a 170 cm column filled with Sulzer DX packing affording purified acetal (2670.1 g, purity: 99.6%, 17.5 / 1 mixture of E- and Z-isomers) as colourless liquid.1H (CDCl3, 400 MHz): δ 1.86 (s, 3H), 2.34 (s, 3H), 3.35 (s, 6H), 4.62 (s, 1H); 6.59 (s, 1H), (d, J 8.1, 2H), 7.21 (d, J 8.1, 2H) ppm.13C NMR (100 MHz, CDCl3): d 13.1 (q), 21.2 (q), 53.6 (q), 107.9 (d), 128.4 (d), 128.9 (d), 129.0 (d), 133.6 (s), 134.1 (s), 136.5 (s). c) Step 3: Preparation of 1-[(1E)-5-Ethoxy-3,5-dimethoxy-2-methyl-1-pentenyl]-4- methylbenzene (Compound of formula (V)) Boron trifluoride acetate (2.86 g, 0.0153 mol.) was added to 1-[(1E)-3,3-Dimethoxy-2- methyl-1-propenyl]-4-methylbenzene (1584.0 g, 7.62 mol.) cooled to 15°C. Vinyl ethyl ether (577.0 g, 8.00 mol.) was added in 3 hours. 30 minutes after the end of the addition, sodium methylate (30% solution in methanol, 13.7 g, 0.076 mol.) was added. The mixture was heated to 25°C for 1 hour and then concentrated under reduced pressure. Crude product (2136.5 g, purity: 94.4%) was used as such for the next step. d) Step 4: Preparation of (2E,4E)-4-Methyl-5-(4-methylphenyl)-2,4- pentanedienal (Compound of formula (I)) Sodium hydroxide (30% aqueous solution, 277 g, 2.08 mol.) was added in 10 minutes to acetic acid (686.0 g, 11.4 mol., 5.5 eq.). 1-[(1E)-5-Ethoxy-3,5-dimethoxy-2-methyl-1- pentenyl]-4-methylbenzene (600.0 g, 2.08 mol.) was added and the mixture was heated up to reflux during 23 hours. The mixture was concentrated, water (233.3 g) and heptane (420.0 g) were added slowly at 80°C and the mixture was allowed to settle. The aqueous phase was decanted and discarded. The organic phase was washed with water (120.0 g). The mixture was dried azeotropically, cooled to 40°C and seeded with a few crystals of product. The mixture was cooled to -20°C. The slurry was filtered and the cake was rinsed with cold (-20°C) heptane (100.0 g). The crystals were dried under vacuum. Yield: 314.3 g yellow crystals (m.p.: 63°C) (purity: 98.4 %). Firmenich SA 441H (CDCl3, 100 MHz) : δ 2.08 (s, 3H), 2.37 3H), 6.24 (dd, J 15.3, 7.7, 1H), 6.90 (s, 1H), 7.20 (d, J 7.9, 2H), 7.29 (d, J 15.3, 1H), 7.29 (d, J 7.9, 2H), 9.62 (d, J 7.7, 1H) ppm.13C NMR (100 MHz, CDCl3): d 13.9 (q), 21.3 (q), 127.8 (d), 129.2 (d), 129.7 (d), 133.4 (s), 133.7 (s), 138.4 (s), 141.0 (d), 158.2 (d), 193.9 (d) ppm. Example 2 Production of ene reductases The codon-harmonized genes encoding ene reductases (EREDs) or formate dehydrogenases (FDHs) from various organisms were expressed in E. coli BL21(DE3) transformed with pET-derived constructs. The cultures were either grown in deep well plates for screening purposes or in shake flasks for the production of biomass for biocatalytic reactions. For the precultures LB or TB medium containing kanamycin (50 µg / mL) was inoculated with the E. coli strains harboring the constructs and incubated at 37 °C and 200 rpm overnight. The precultures were used to inoculate the main cultures in LB or TB medium containing kanamycin (50 µg / mL) at OD 0.1, which was incubated at 37°C until the optical density at 600 nm (OD600) reached approximately 0.8. Expression of the genes was induced by 0.1-0.2 mM IPTG (isopropyl-D-thiogalactopyranoside) and the cultures were shaken at 20-25°C for 20 h. The cells were harvested by centrifugation, and then resuspended in 50 mM potassium phosphate buffer (KPi, pH 7 to pH 8) to an OD of 50, aliquoted and stored at -20°C. Protein production was confirmed by SDS-PAGE. Example 3 Screening of ene reductases for the reduction of (2E,4E)-4-methyl-5-(4-methylphenyl)-2,4- pentanedienal to (4E)-4-methyl-5-(4-methylphenyl)-pent-4-enal The screening ERED library was performed in deep well plates using the following procedure: whole cells corresponding to 1 mL cultures containing EREDs, were lysed using 150 µL of a lysis buffer containing lysozyme, Triton X-100 and DNAse, and used directly in an assay at 0.8 mL scale adding 2 g / L (2E,4E)-4-methyl-5-(4- methylphenyl)-2,4-pentanedienal, 10 U / mL GDH, 50 mM glucose, 0.2 mM NADP+and NAD+, with optionally 10% EtOH or 10% cyclohexane in 100 mM phosphate buffer, pH 7.5, 25°C, 1000 rpm, in a shaking incubator over-night. The reactions were done in Firmenich SA 45 duplicate. The samples were extracted mL EtOAc and analyzed by GC-FID or GC-MS. GC-FID method: DB-1 column, 10 m x 0.1 mm, 0.1 µM; temperature gradient: 100 °C for 1 min, temperature rise 25°C / min to 300°C, keep 2 min at 300°C. Carrier: H2, injector 250°C, and detector 300°C, split and injection volume varied depending on the substrate concentration. (2E,4E)-4-methyl-5-(4-methylphenyl)-2,4-pentanedienal and (4E)-4- methyl-5-(4-methylphenyl)-pent-4-enal were used as reference. Several of the EREDs were active and could fully convert (2E,4E)-4-methyl-5-(4- methylphenyl)-2,4-pentanedienal. It has to be noted that tested ene reductases allow converting (2E,4Z)-4-methyl-5-(4-methylphenyl)-2,4-pentanedienal into (4Z)-4-methyl-5- (4-methylphenyl)-pent-4-enal. Table 1. Conversion of (2E,4E)-4-methyl-5-(4-methylphenyl)-2,4-pentanedienal using GDH as cofactor recycling enzyme SEQ ID NO accession number or conversion % name 1 IviERED1 97.8 2 IviERED2 97.7 3 IviERED7 92.3 4 CsERED1 94.0 5 G1FCG0 94.0 6 Q39172 91.3 7 Q9SLN8 91.7 8 P76113 87.7 9 QST04860 70.2 Firmenich SA 46 10 TFK33617 11 BAA12582 92.9 12 WP_013369181 78.2 13 QBR53093 94.7 14 BAD76617 93.0 15 WP_130413757 73.6 16 HCT39750 86.2 17 MetaERED 84.8 18 AHC69715 62.2 19 BAE76493 82.2 20 P71278 93.4 21 WP_032896199 93.0 22 WP_004717625 96.1 23 AOF89574 73.4 24 SCX05177 81.4 25 SMC61091 79.8 26 Q9Z3T1 66.9 27 F8EUA7 93.0 28 Q5NLA1 98.7 29 WP_124307314 87.3 30 A0A0D6MPY3 96.5 Firmenich SA 47 31 WP_011252080 32 WP_146796646 88.8 33 WP_182276406 70.1 34 WP_171515077 70.2 35 WP_008897757 79.5 36 WP_003198668 84.4 37 AAF02539 85.9 38 BAD24850 89.4 39 CCE93449 97.3 40 CAA97878 97.1 41 AAA83386 84.4 42 CAA37666 88.1 43 EPY51052 97.9 44 A3LT82 86.6 In all cases the reduction of substrate and product aldehydes to the respective alcohols has been observed. This is most likely related to ketoreductases which are present in E. coli. This has been observed and described many times before in literature. A well-known approach to reduce the formation of alcohol is the down-regulation or knock-out of ketoreductases as mentioned in the description section above. Example 4 Reduction of (2E,4E)-4-methyl-5-(4-methylphenyl)-2,4-pentanedienal to (4E)-4-methyl-5- (4-methylphenyl)-pent-4-enal at higher substrate concentration Firmenich SA 48 The reaction at higher substrate was performed at 1 mL scale using the following procedure: whole cells containing EREDs at OD10, 20 mg / mL (2E,4E)-4- methyl-5-(4-methylphenyl)-2,4-pentanedienal, 10 U / mL GDH, 150 mM glucose, 1 mM NADP+, optionally 2 µM FMN, 10% toluol in 200 mM phosphate buffer, pH 8, 25°C, 1000 rpm, over-night. Reactions were done in duplicate. The reactions were extracted with EtOAc and analyzed by GC-FID as above. Table 2. Conversion of (2E,4E)-4-methyl-5-(4-methylphenyl)-2,4-pentanedienal at higher substrate concentration using GDH as cofactor recycling enzyme SEQ ID NO Accession number or wt % wt % wt % substrate name product product aldehyde alcohol 1 IviERED1 67.6 3.3 29.1 2 IviERED2 35.4 6.1 58.4 3 IviERED7 16.4 4.6 79.0 4 67.7 7.0 25.2 CsERED1 5G1FCG069.3 5.5 25.26Q3917254.2 4.0 41.97Q9SLN852.4 8.0 39.79QST048607.8 6.4 85.810 31.4 10.7 57.9 TFK33617 12 30.4 1.8 67.8 WP_013369181 15 60.9 6.2 32.9 WP_130413757 16 94.4 3.5 2.1 HCT39750 17 15.5 0.9 83.6 MetaERED Firmenich SA 49 19 3.1 28.5 BAE76493 20 50.6 13.0 36.4 P71278 21 24.0 0.7 75.3 WP_032896199 22 55.1 3.2 41.7 WP_004717625 23 11.8 3.3 84.9 AOF89574 24 23.8 3.7 72.5 SCX05177 25 11.8 2.7 85.4 SMC6109126Q9Z3T140.3 4.5 55.227F8EUA771.3 3.7 25.028Q5NLA119.4 1.9 78.729 84.9 7.3 7.8 WP_12430731430A0A0D6MPY375.2 4.0 20.931 87.2 2.1 10.7 WP_011252080 34 33.4 5.3 61.3 WP_171515077 35 16.3 2.7 81.1 WP_008897757 37 29.2 1.6 69.2 AAF02539 38 86.3 4.6 9.2 BAD2485040CAA9787855.3 1.1 43.641 39.7 1.4 59.0 AAA83386 42 23.5 0.5 76.0 CAA37666 43 95.0 2.5 2.5 EPY51052 Firmenich SA 50 44A3LT823.0 23.7In Table 2 it can be seen that product formation was observed with all chosen enzymes at higher substrate concentration. The relative alcohol formation was significantly reduced when higher substrate concentrations were used. Example 5 Reduction of (2E,4E)-4-methyl-5-(4-methylphenyl)-2,4-pentanedienal to (4E)-4-methyl-5- (4- 4-enal with FDH for cofactor recycling The most were tested with FDH for cofactor regeneration. The reaction was performed at 1 mL scale using the following procedure: whole cells containing EREDs at OD10, whole cells containing FDH at OD5, 20 mg / mL (2E,4E)-4-methyl-5-(4- methylphenyl)-2,4-pentanedienal, 1 M sodium formate, 1 mM NADP+, optionally 2 µM FMN, 10% toluol in 200 mM phosphate buffer, pH 7.5, 25°C, 1000 rpm. Reactions were done in duplicate. The reactions were extracted with EtOAc and analyzed by GC-FID as above. Table 3. Conversion of (2E,4E)-4-methyl-5-(4-methylphenyl)-2,4-pentanedienal at higher substrate concentration using FDH as cofactor recycling enzyme FDH ERED wt % product wt % product wt % aldehyde alcohol substrate Mv4MFDH EPY51052 83.8 0.4 15.8 HCT39750 60.8 0.4 38.9 WP_124307314 95.1 1.6 3.2 CsERED1 27.6 0.2 72.2 WP_011252080 92.5 1.0 6.5 IviERED1 16.4 0.2 83.4 LbFDH EPY51052 86.0 0.7 13.3 HCT39750 55.4 0.4 44.2 Firmenich SA 51 WP_124307314 93.8 2.4 3.8 CsERED1 54.5 0.7 44.8 WP_011252080 91.5 1.5 7.0 IviERED1 7.3 0.1 92.6

[0003] Firmenich SA 52 Sequence listing Sequence name Amino acid SEQ WT nucleic acid E. coli expression ID NO Seq ID NO optimized SEQ ID NO IviERED1 1 45 89 IviERED2 2 46 90 IviERED7 3 47 91 CsERED1 4 48 92 G1FCG0 5 49 93 Q39172 6 50 94 Q9SLN8 7 51 95 P76113 8 52 96 QST04860 9 53 97 TFK33617 10 54 98 BAA12582 11 55 99 WP_013369181 12 56 100 QBR53093 13 57 101 BAD76617 14 58 102 WP_130413757 15 59 103 HCT39750 16 60 104 MetaERED 17 61 105 AHC69715 18 62 106 BAE76493 19 63 107 P71278 20 64 108 WP_032896199 21 65 109 WP_004717625 22 66 110 AOF89574 23 67 111 SCX05177 24 68 112 SMC61091 25 69 113 Q9Z3T1 26 70 114 F8EUA7 27 71 115 Q5NLA1 28 72 116 WP_124307314 29 73 117 A0A0D6MPY3 30 74 118 WP_011252080 31 75 119 WP_146796646 32 76 120 WP_182276406 33 77 121 WP_171515077 34 78 122 WP_008897757 35 79 123 WP_003198668 36 80 124 AAF02539 37 81 125 BAD24850 38 82 126 CCE93449 39 83 127 CAA97878 40 84 128 AAA83386 41 85 129 CAA37666 42 86 130 Firmenich SA 53 EPY51052 43 131 A3LT82 44 88 132 LbFDH (AEB72361) 133 135 137 MvFDH-var 134 136 138 Sequences Sequence Number (ID): 1 MEEVRNKQVV FKDYINGFPK ESDMLLKSSS TICLKLPQGS NGVLVKNLYL SCDPYMRARM 60 TKTEGSYFPP FTPGSPISGY GVAKVLDSGH PDLKKGDLVW GGTGWEEYSI IDAPESLFKI 120 QHTDMPLSYY TGILGMPGMT AYIGFYEICA PKKGEYVFVS AASGAVGQLV GQFAKLSGCY 180 VVGSAGTKEK VDLLKNKFGF DEAFNYKEEQ DLNAALKRYF PDGIDIYFEN VGGKMLEAVL 240 SNMRLNGRIS ACGMISQYNL EQPEGVCNLF LLVGKRLRMQ GFIVSDYYHL YPKYMEMVMP 300 LIKQGTISYI EDIVEGLESA PAALVGLFSG RNVGKQVVVV ARE 343 Sequence Number (ID): 2 MEEVKNKQVV LKDYINGFPK ESDMLLKSSS TICLKLPQGS NGLLVKNLYL SCDPYMRNRM 60 SKSQGSYVDS LTPGLPITGY GVAKVLDSGH SDFKKGDLVW GWTGWEEYSI IDAPESLFKI QHTDMPLSYY TGILGMPGMT AYAGFYEICA PKKGEYVFVS AASGAVGQLV GQFAKLSGCY 180 VVGSAGTKEK VDLLKNKFGF DEAFNYKEEQ DLNAALKRYF PDGIDIYFEN VGGKMLEAVL 240 SNMRLNGRIS ACGMISQYNL EQPEGVCNLF LLVGKRLRMQ GFIVSDYYHL YPKYMEMVMP 300 LIKQGTISYI EDIVEGLESA PAALVGLFSG RNVGKQVVVV ARE 343 Sequence Number (ID): 3 MAEVVERSPE VVIVRNKQVI FKDYVNGYPK ETDMVVTSDA TIRLKLPENE SGLILTKNLY 60 LSCDPYMRGR MSKTSEGSYV PSFTPGSLIS GYGVAKVLDS THPEYKKGDL ISGIISWEEY 120 SLIKNPELFI KIQHTDVPLS YYTGILGMAG VTAYAGFYEI CSPKKGDTVF VSSASGAVGQ 180 LVGQFAKLHG CYVVGSAGSK EKVDLLKNKF GFDEAFNYKE EHDLNSTLKR CFPDGIDIYF 240 ENVGGKMLDA VLCNMRLHGR IAVCGMISQY NLNEHQGINN LIFVILKRIR MEGFLVTDHY 300 HLFPKFLEMV LPLIQEGKIT YVEDTIEGLE NAPAALVGLF SGKNVGKQIV DLTQE 355 Sequence Number (ID): 4 MGEMVENKQI VLKDYVSGYP KESDMVTQVS KMSLNVPHGS NGIVVKNLYL SCDPYMRPRM 60 TKSEGGYVDS FTPGQPITGY GVAKVLDSGT PKFKKGDLVW GFTGWEEYSL ITKTDTLFKI EHTDVPLSYY TGLLGMPGMT AYAGFYKVAT PKKGEYVFVS AASGAVGQLV GQFAKLLGCY VVGSAGSKEK VDLLKNKFGF DEAFNYKEEE DLAAALKRYF PDGIDIYFEN VGGKMLDAVL VNMRPHGRIA VCGMISQYNL EKPEGIYNLT YVIMKQLRIE GFLVFDYYHL YPKLLELVLP Firmenich SA 54 YIKEGKINYV EDIAEGLESA RNVGKQVVAV ARE 343 Sequence Number (ID): 5 MASGGEMQVS NKQVIFRDYV TGFPKESDME LTTRSITLKL PQGSTGLLLK NLYLSCDPYM 60 RARMTNHHRL SYVDSFKPGS PIIGYGVARV LESGNPKFNP GDLVWGFTGW EEYSVITATE 120 SLFKIHNTDV PLSYYTGLLG MPGMTAYAGF YEICSPKKGE TVYVSAASGA VGQLVGQFAK 180 LTGCYVVGSA GSKEKVDLLK NKFGFDEAFN YKEEADLDAA LRRYFPDGID IYFENVGGKM 240 LDAVLPNMRP KGRIAVCGMI SQYNLEQPEG VRNLMALIVK QVRMEGFMVF SYYHLYGKFL 300 ETVLPYIKQG KITYVEDVVD GLDNAPAALI GLYSGRNVGK QVVVVSRE 348 Sequence Number (ID): 6 MTATNKQVIL KDYVSGFPTE SDFDFTTTTV ELRVPEGTNS VLVKNLYLSC DPYMRIRMGK 60 PDPSTAALAQ AYTPGQPIQG YGVSRIIESG HPDYKKGDLL WGIVAWEEYS VITPMTHAHF KIQHTDVPLS YYTGLLGMPG MTAYAGFYEV CSPKEGETVY VSAASGAVGQ LVGQLAKMMG 180 CYVVGSAGSK EKVDLLKTKF GFDDAFNYKE ESDLTAALKR CFPNGIDIYF ENVGGKMLDA 240 VLVNMNMHGR IAVCGMISQY NLENQEGVHN LSNIIYKRIR IQGFVVSDFY DKYSKFLEFV 300 LPHIREGKIT YVEDVADGLE KAPEALVGLF HGKNVGKQVV VVARE 345 Sequence Number (ID): 7 MAEEVSNKQV ILKNYVTGYP KESDMEIKNV TIKLKVPEGS NDVVVKNLYL SCDPYMRSRM 60 RKIEGSYVES FAPGSPITGY GVAKVLESGD PKFQKGDLVW GMTGWEEYSI ITPTQTLFKI 120 HDKDVPLSYY TGILGMPGMT AYAGFHEVCS PKKGETVFVS AASGAVGQLV GQFAKMLGCY 180 VVGSAGSKEK VDLLKSKFGF DEAFNYKEEQ DLSAALKRYF PDGIDIYFEN VGGKMLDAVL 240 VNMKLYGRIA VCGMISQYNL EQTEGVHNLF CLITKRIRME GFLVFDYYHL YPKYLEMVIP 300 QIKAGKVVYV EDVAHGLESA PTALVGLFSG RNIGKQVVMV SRE 343 Sequence Number (ID): 8 MGQQKQRNRR WVLASRPHGA PVPENFRLEE DDVATPGEGQ VLLRTVYLSL DPYMRGRMSD 60 EPSYSPPVDI GGVMVGGTVS RVVESNHPDY QSGDWVLGYS GWQDYDISSG DDLVKLGDHP QNPSWSLGVL GMPGFTAYMG LLDIGQPKEG ETLVVAAATG PVGATVGQIG KLKGCRVVGV 180 AGGAEKCRHA TEVLGFDVCL DHHADDFAEQ LAKACPKGID IYYENVGGKV FDAVLPLLNT 240 SARIPVCGLV SSYNATELPP GPDRLPLLMA TVLKKRIRLQ GFIIAQDYGH RIHEFQREMG 300 QWVKEDKIHY REEITDGLEN APQTFIGLLK GKNFGKVVIR VAGDD 345 Sequence Number (ID): 9 MAPVTNGRII FNSIPTGFPV PGETTIYDTT ETIDLDTAPL DGGFLLKTLE LSVDPYMRGG 60 MRAPEKKSYS APFTLGQPLR GYGVGVVLRS ENPQVKAGDH LYGFFEHTHY SIRKDLTGLQ AIENAYNLPW SVFIGVIGMP GKTAYMAWKE YAHPKQGETV FVSTGAGPVG SFVIQLAKAD Firmenich SA 55 GLKVIASAGS EEKVQFMKEV TNTAEVLEKE GPIDIYWDNV GGETLEAALN 240 AANVNARFIE CGMISGYNSG GAPVRNIFHV IGKSITMTGF IVSRIEPKYS AEFYKEVPAK 300 VASGELKYRE HVYNGLEKLG DVILAVQKGE NKAKAVVHVA DD 342 Sequence Number (ID): 10 MASVTNGRVL FNSIPEGFPE PGKTVVYDTS ENIDLDTVPL NGGFLLKTLD LSIDPYMRGR 60 MRAPEKKSYS PPFLLNQPID GYGVGVVLRS ELPEVKAGDH LYGFFKHVQY DVRTNLEGLS 120 KLPNEHGLSW SVYVGAAGMP GKTAYMAWKE YSQAKKGETV FVSAGAGPVG SLVIQFAKAD 180 GLKVIGSAGS DEKVQFMKEC GADVAFNYKT TNTKEVLEKE GPIDIFWDNV GGETLEAALE 240 AANVNARFIE CGMISGYNSG GAPIRNLFHV VSKSISMHGF IVSRLEPKYG KEFYETIPHK 300 LASGELKHRE HVFDGLDKVG EALLAVQKGT NKAKAVVKVA DE 342 Sequence Number (ID): 11 MNPKYKPLFE PFTFKSGVTI NNRIAVAPMT HYASNEDGTI SEAELDYIIP RSKEMGMVIT 60 ACANVTPDGK AFPGQPAIHD DSNIPGLKKL AQAIQAQGAK AVVQIHHGGI ECPSELVPQQ DVVGPSDVFD NGKQIARALT EEEVENIVKA FGEATRRAIE AGFDGVEIHG ANGYLIQQFY 180 SPKTNQRTDR WGGSDEKRLA FPLAIVDEVK KAASEHAKGA FLVGYRLSPE EPETPGLTMT 240 ETYTLVDALG DKELDYLHIS LMDVNSKARR GADPTRTRMD LLNERVGNKV PLIAVGSIHS 300 ADDALAVIEN GIPLVAMGRE ILVDPNWTVK VKEGREKQIE TVIKGTDKEK YHLPEPLWQA 360 IVNTQGWVPY KD 372 Sequence Number (ID): 12 MNPKYNPLFE AFTLPSGVTL KNRITMAPMT NFASHENGEV SDEELAYYRE RSGGVGAVIT 60 ACVYVTPDGK GFVNEFSADK DEMIPSLRRL ADTIHQEGAK AILQIYHGGR LCPPDQIPDG 120 QPISASAVAE EKEGAPVPRE MTSDDIHRVI RAYGEATRRA IEAGYDGVEL HGANGYLVQQ 180 FFSPHSNIRT DEWGGSLEER LTFPLAVVHE VKKVIAEHAK RPFIFGYRLS PEEGHTPGIT 240 LDDTMVLVDR LADEGLDYLH ISVNHFFGGS FRDRSDERSR TVLIHEKVGN RVPVMGVGSL 300 NTPDEALAAL ETGVPLVSLG RPLLMEPQWV QKVQNGTEDT IRTTLSKQAQ QELVIPDYLW 360 GALTTIPGWM PVTD 374 Sequence Number (ID): 13 MNTELLFKPF KAGNLSLPNR IVMAPMTRNF SPQGIPGPEV AAYYRRRAEN AVGLIITEGT 60 AINHPAAVEH TSIPNFYGEG LEGWAKVVEE VHAVGGKIIP QLWHVGTARK IGADNQPNPE ALPVGPSGIS PAGEKVVEPL TEAEIADIIS AYAQAAADAQ RVGFDGIELH GAHGYLIDQF 180 FWDKTNKRTD QYGGNLVQRT RFAVEVIEAC RRAVGPNFPI VLRFSQWKMY HYEEKLAQTP 240 QELEQFLTPL VKAGVDIFHC SSRRFWEPEF EGSDLNLAAW TKKITGKPVI TVGSIGLEKA 300 FLSDLEKNNN RQTDQSSSVE ARLEQLVGQV EREEADLVAV GRALLVDPAF AVKLRDQQIE 360 Firmenich SA 56 EIIPYSDEVL KTLN 374 Sequence Number (ID): 14 MNTMLFSPYT IRGLTLKNRI VMSPMCMYSC DTKDGAVRTW HKIHYPARAV GQVGLIIVEA 60 TGVTPQGRIS ERDLGIWSDD HIAGLRELVG LVKEHGAAIG IQLAHAGRKS QVPGEIIAPS 120 AVPFDDSSPT PKEMTKADIE ETVQAFQNGA RRAKEAGFDV IEIHAAHGYL INEFLSPLSN 180 RRQDEYGGSP ENRYRFLGEV IDAVREVWDG PLFVRISASD YHPDGLTAKD YVPYAKRMKE 240 QGVDLVDVSS GAIVPARMNV YPGYQVPFAE LIRREADIPT GAVGLITSGW QAEEILQNGR 300 ADLVFLGREL LRNPYWPYAA ARELGAKISA PVQYERGWRF 340 Sequence Number (ID): 15 MTGKLFSPIS VGPLSLPNRI FMAPLTRMRS REPGDVPVLP LMAEYYRQRA NAGLIISEAT 60 QVSPQGKGYM GTPGIHSAEQ VEAWRDITRA VHDEGGHIAI QLWHVGRVSH HSLQPDRQLP 120 VSASAIPYEN KTTIRGEDSK PQRVACDTPR ALRTDEIPGL IETYRQATIN AREAGFDLVE 180 VHAAHGYLLH QFQSAVSNHR DDAYGGCLEN RARLTLEVVD ACIAAWDAAH VGIRISPLGT 240 FNGLDDSAGL EMGLYLAEQL AKRNIAYLHL SEPDWAGGPA HSDEFRQALR DRFPGVIIGA 300 GNYTVEKAEA LLAKGYIDAA AFGRPYISNP DLAERFRTGA ALAMLNPATL YGGGEEGYTD 360 YPALA 365 Sequence Number (ID): 16 MSGKLFTPVT IGGFTLPNRV LMAPLTRMRS SQPGDVPNEL MQAYYVQRAS AGMIIAEATQ 60 ISPQGKGYMD TPGIYSAEQV AGWKKITQAV HEANGHICLQ LWHVGRVSHH SLQPDQQLPV 120 SASAIPYENR TTVRGEDGKV KRVACDTPRA LELTEIPGLI EDYRRATVNA REAGFDMVEV 180 HAAHGYLLHQ FQSATSNQRN DAYGGSLENR ARLTLEVLDA VIGAWDAAHV GIRISPLGIF 240 NGLDDRDGLD MGLYLAEQFA LRGIGYLHLS EPDWAGGPVL NEEFRVALRA RFPGIIIAAG 300 NYSVEKAEGL LEKGLIDAAA FGRPFIANPD LPQRLRKGAE LNAVNAATLY GGGAEGYTDY 360 PALA 364 Sequence Number (ID): 17 MSGKLFTPFS SGSFTFPNRV IMAPLTRMRA SQPGDIPNEL MQTYYVQRAS AGLIIAEATQ 60 ISPQGKGYMD TPGIYSAEQV QGWRKITQAV HEAGGHIALQ LWHVGRVSHH SLQPDQQLPV 120 SASAIPYQNR TTVRGEDGKP TRVDCDTPRA LELSEIPGVI EDYRRATVNS REAGFDMVEV 180 HAAHGYLLHQ FQSAESNKRE DAYGGSLENR ARLTLEALDA VIGAWDAKHV GIRISPLGTF 240 NGLDDKDGLE MALYLTREFT KRGIAYLHLS EPDWAGGPAH GDEFRQALRD AFPGTIIGAG 300 NYTVEKSEML LAKGFIDAAA FGRPFIANPD LPVRLQKGAE LNNVVAATLY GGGAEGYTDY 360 PALA 364 Sequence Number (ID): 18 Firmenich SA 57 MKLLQPLQIG PLTLPNRVFM PGDVPTTLMG EYYRQRASAG LIITEATQIS 60 FQAKGYSGSP GIHSAEQIAA WKHINEGIHA DGGHSAVQVW HTGRVSHTSL QPGGEAPVAP 120 SALPAGARTT LRDEQGDLIR VETSAPRALS EAEIAGIVAD FGLAAINARE AGFDFIELHA 180 AHGYLLHQFL TPSANQREDR YGGSVENRAR IVLEAVDAAV ANWSAERVGI RVFPLGGFNG 240 VDNGEDQEAA GLYLIRELAK RNLAYLHLSE PDWAGGKPLR DEFRQAIRAA YPGVIIAAGA 300 YTAEKGEDLI GRGLIDAVAF GRSYIANPDL VERLRLQAPL NEHRAQFDYA NGPEGYTDYP 360 FLKQA 365 Sequence Number (ID): 19 MSSEKLYSPL KVGAITAANR IFMAPLTRLR SIEPGDIPTP LMAEYYRQRA SAGLIISEAT 60 QISAQAKGYA GAPGIHSPEQ IAAWKKITAG VHAENGHMAV QLWHTGRISH ASLQPGGQAP 120 VAPSALSAGT RTSLRDENGQ AIRVETSMPR ALELEEIPGI VNDFRQAIAN AREAGFDLVE 180 LHSAHGYLLH QFLSPSSNHR TDQYGGSVEN RARLVLEVVD AGIEEWGADR IGIRVSPIGT 240 FQNTDNGPNE EADALYLIEQ LGKRGIAYLH MSEPDWAGGE PYTDAFREKV RARFHGPIIG 300 AGAYTVEKAE TLIGKGLIDA VAFGRDWIAN PDLVARLQRK AELNPQRAES FYGGGAEGYT 360 DYPTL 365 Sequence Number (ID): 20 MSAEKLFTPL KVGAVTAPNR VFMAPLTRLR SIEPGDIPTP LMGEYYRQRA SAGLIISEAT 60 QISAQAKGYA GAPGLHSPEQ IAAWKKITAG VHAEDGRIAV QLWHTGRISH SSIQPGGQAP VSASALNANT RTSLRDENGN AIRVDTTTPR ALELDEIPGI VNDFRQAVAN AREAGFDLVE 180 LHSAHGYLLH QFLSPSSNQR TDQYGGSVEN RARLVLEVVD AVCNEWSADR IGIRVSPIGT 240 FQNVDNGPNE EADALYLIEE LAKRGIAYLH MSETDLAGGK PYSEAFRQKV RERFHGVIIG 300 AGAYTAEKAE DLIGKGLIDA VAFGRDYIAN PDLVARLQKK AELNPQRPES FYGGGAEGYT 360 DYPSL 365 Sequence Number (ID): 21 MKTAKLFSPL KVGALTLPNR VFMAPLTRLR SIEPGDIPTP LMAEYYRQRA SAGLIITEAT 60 QISFQAKGYA GAPGLHTQEQ LNAWKKITQA VHEEGGHIAV QLWHVGRISH SSLQPGQQAP 120 VAPSAIAADT RTTVRDENGA WVRVPCSTPR ALETEEIPGI INDFRQATAN AREAGFDYIE 180 LHAAHGYLLH QFMSPASNQR TDQYGGSIEN RTRLTLEVVD ATAAQWSAER IGIRISPLGP 240 FNGLDNGEDQ EEAALYLIDE LNKRHIAYLH ISEPDWAGGK PYSEAFRDAV RARFKGVIIG 300 AGAYTAEKAE ELIEKGFIDA VAFGRSYISN PDLVARLQQH APLNEPDGET FYGGGAKGYT 360 DYPTL 365 Sequence Number (ID): 22 MKTAKLFSPL KVGAFTLPNR VFMAPLTRLR SIEPGDIPTP LMAEYYAQRA SAGLIITEAT 60 Firmenich SA 58 QVSFQAKGYA GAPGLHTQEQ VHEKQGHIAV QLWHVGRISH HSLQPNQQAP 120 VAPSAIAADT RTTIRDENGD WVRVPCSTPR ALELQEIPAI VDDFRNATAN AREAGFDFIE 180 IHAAHGYLLH QFMSPASNQR TDAYGGSIEN RTRLTLEVVD ATAAEWGAEH IGIRISPLGP 240 FNGLDNGEDQ EDAALYLIDE LNKRKIAYLH ISEPDWAGGK PYTDAFRDAV RARFNGIIVG 300 AGAYTAEKAE TLIEKGFIDA VAFGRSYIAN PDLVERLQQQ APLNTPDGDT FYGGGAKGYT 360 DYPTLS 366 Sequence Number (ID): 23 MTSLFDPLKI GDIQLANRIV MAPLTRNRSP GAVPNTLNAA YYEQRASAGL LITEATAISH 60 QGQGYADVPG LYKPEALEGW KQVTDAVHKA GGKIVVQMWH VGRISHDTLQ PNGGKPVAPS 120 AIRAKSKTYL INADGTGSFA ETSEPRALEK DELPGIIEDY RRAARAAVDA GFDGVEIHAA 180 NGYLLDQFLR SGSNERTDEY GGSIENRARL LFQVVDVITK EIGAGRTAIR ISPVTPANDS 240 SDPNPQPLFT YVVEGLAKYD LAYIHIIEGA TGGPRDHQQG DAPFDYAALR AAYQAAGGKA 300 AWMVNNGYNR ELAIDAVEEG KADLVAFGKL FIANPDLVER LKNDTVLNPP DQATFYGGGA 360 KGYTDYPALE NVA 373 Sequence Number (ID): 24 MTKLFEPAQA GDIALANRIV MAPLTRNRSP GAIPNNLNAA YYEQRATAGL IVTEGTPVSQ 60 QGQGYADVPG LYKQEAIDGW KAVTDGVHKA GGKIVAQIWH VGRISHTSLQ PHGGQPVAPS PIKANSKTYI INDDGTGSFA ETSEPREISL QEIPVILEDY RTGARAAIDA GFDGVEIHAA 180 NGYLIDQFLK SGTNQRTDAY GGSIENRARF LLEVVDTVTK EIGAGRTGIR LSPVTPANDI 240 FEADPQPLFE YVARELGSRG LAFIHVIEGA TGGPRDFKQG DKPFDYDALK AAYTNAGGKG 300 LWIANNGYDR ESAIAATESG KVDAVAFGKA FISNPDLVQR LKENAALNEP NQQTFYGGGA 360 EGYTDYPALA 370 Sequence Number (ID): 25 MSDLFEPTKA GDIALANRIA MAPLTRNRSP GEAPNDLNVT YYQQRATAGL IITEGTPITH 60 QGQGYAHVPG LYKPEALEGW KKVTDAVHKA GGKIVTQIWH VGRVSHTSLQ PGEGKPVAPS AITAKSKTYI INPDGSGAFA DTSEPRALSL EEIPGILEDY RVAARAAVDA GFDGVEIHAA 180 NGYLLDQFLR SGSNQRTDAY GGSIENRTRL TLEVAAVVAK EIGGGRTGIR ISPVTPANDV 240 FDPEPQPLFN HLVSKLAGLD LAFIHVIEGA TGGPRDFKQG DKPFDWDELR KTYRDAGGKG 300 AWMVNNGYDK ASATEAVASG RADIVTFGKL FIANPDLVRR FKEDAPLNEP NKATFYGGGA 360 EGYTDYPFLP 370 Sequence Number (ID): 26 MPTLFDPLTL GDLQSPNRVL MAPLTRGRAT REHVPTELMI EYYTQRASAG LIITEATGIT 60 QEGLGWPYAP GIWSDEQVEA WKPVTQAVHE AGGRIILQLW HMGRTVHSSF LGGAKPVSSS Firmenich SA 59 ATRAPGQAHT YEGKQDYDEA LLNDYEHAAK NAMAAGFDGV QIHAANGYLI 180 DQFLRDNSNV RGDAYGGSIE NRIRLLVEVT RRVAETVGAE KTGVRLSPNG DSQGVNDSNP 240 EPLFSAAAKA LDEIGIAHLE LREPGYEGTF GKADRPPVHP VIRQAFSRTL ILNSDYTLET 300 AQAALATGEA DAITFGRPFL ANPDLPHRFA ERLPLNKDVM ETWYSQGPEG YVDYPTADQK 360 Sequence Number (ID): 27 MPTLFDPIRL GAVTAKNRIL MAPLTRGRAT RDHVPTDIMI KYYAQRASAG LIISEATGIS 60 QEGLGWPYAP GIWNEAQTQA WIPITQAVHD AGGLIFVQLW HMGRLVPSSV SGMQPVSASA 120 TKAPDLAHTY EGKKPFDVAR PLEIAEIPRL LDDYERATRN ALSAGFDGVQ IHAANGYLID 180 EFLRDGTNLR KDAYGGTPEH RIRLLREVTE RVISVIGADR TSVRLSPNGE IQGASDSHPE 240 NIFLPAARML SDLGIAFLGL REGTPEGTFG RTDQPKLSPK IREVFNPPLI LNQDYNLETA 300 QEALDSGVAD AISFGRLFIS NPDLPRRFFE GSPLIKDNIA TWYTQGAEGY TDYPLIGNEI 360 PA 362 Sequence Number (ID): 28 MPSLFDPIRF GAFTAKNRIW MAPLTRGRAT RDHVPTEIMA EYYAQRASAG LIISEATGIS 60 QEGLGWPYAP GIWSDAQVEA WLPITQAVHD AGGLIFAQLW HMGRMVPSNV SGMQPVAPSA SQAPGLGHTY DGKKPYDVAR ALRLDEIPRL LDDYEKAARH ALKAGFDGVQ IHAANGYLID 180 EFIRDSTNHR HDEYGGAVEN RIRLLKDVTE RVIATIGKER TAVRLSPNGE IQGTVDSHPE 240 QVFIPAAKML SDLDIAFLGM REGAVDGTFG KTDQPKLSPE IRKVFKPPLV LNQDYTFETA 300 QAALDSGVAD AISFGRPFIG NPDLPRRFFE KAPLTKDVIE TWYTQTPKGY TDYPLLGD 358 Sequence Number (ID): 29 MTSLFEPIEL GSIYAKNRIL MAPLTRGRST RDHVPTPIMA EYYAQRAGAG LIISEATGIS 60 REGLGWPYAP GLWSQEQVEA WKPITAAVHA KGGKIVAQLW HMGRMVHSSV TGQQPVSCSA TKAPEALHTY DGKQAPEVAR PLTKEDIARI LNDYENAARN ALQAGFDGVQ IHAANGYLID 180 EFLRDGTNHR SDEYGGSPEN RIRFLREVTE RVIATIGAHK TSVRLSPNGD TQGCIDSHPE 240 QVFVPASKLL NDLDIAFLEL REPGPNGTFG KTDQPKLHGP IREVFRKPLV LNQDYTREEA 300 IETVATGVAD AISFGRPFLA NPDLVRRLED NLPQNKDDIR TWYSQGAEGY TDYPLAR 357 Sequence Number (ID): 30 MTTLFDPIKL GAIAAPNRII MAPLTRGRSS RGHVPSALMA EYYAQRASAG LIITEATGIS 60 QEGLGWPYAP GIWSDEQVEA WKPIVRAVHD KGGRIVMQLW HMGRMVHSNV TGLQPVSASP TTAPGEAHTY DGKKPYEQAR ALDISEIPRL LADYENATRN ALAAGFDGVQ IHAANGYLID 180 EFLRDSTNKR TDAYGGEPEN RIRLLREVTE RVISVAGADR TAVRLSPNGE TQGTIDSNPI 240 SVFVPAAKML YDLGLAWLEL REPGPNGTFG RTDQPKLSPQ IRQVFKAPLV LNSDYTLEEA 300 ETAVLEDRAD AISFGRKFLA NPDLPHRFKS GLPLNRDEMK TWYSQGPQGY VDYPAAS 357 Firmenich SA 60 Sequence Number (ID): 31 MPTLFDPIDF GPIHAKNRIV MSPLTRGRAD KEAVPTPIMA EYYAQRASAG LIITEATGIS 60 REGLGWPFAP GIWSDAQVEA WKPIVAGVHA KGGKIVCQLW HMGRMVHSSV TGTQPVSSSA 120 TTAPGEVHTY EGKKPFEQAR AIDAADISRI LNDYENAARN AIRAGFDGVQ IHAANGYLID 180 EFLRNGTNHR TDEYGGVPEN RIRFLKEVTE RVIAAIGADR TGVRLSPNGD TQGCIDSAPE 240 TVFVPAAKLL QDLGVAWLEL REPGPNGTFG KTDQPKLSPQ IRKVFLRPLV LNQDYTFEAA 300 QTALAEGKAD AIAFGRKFIS NPDLPERFAR GIALQPDDMK TWYSQGPEGY TDYPSATSGP 360 N 361 Sequence Number (ID): 32 MPSLFDSIDL GAVHAANRII MSPLTRARAT EGAVPTPLMV EYYAQRAGAG LIISEATGIS 60 REGLGWPWAP GIWSAEQVAA WKPITKAVHE RGGKIVCQLW HMGRMVHSSV TGLQPVSASP TTAPGQSHTY EGKKPYEEAR ELRVDEIPRI LADYENAARN AIEAGFDGVQ IHAANGYLID 180 EFLRDGTNHR KDEYGGAPEN RIRLLREVTE RVVATIGADR TSVRLSPNGD TQGTDDSAPE 240 KVFVPAAKVL QDLGVAWLEL REPGPEGTFG KTDEPKLSPE IRKVFSRPLV LNQDYTLEDA 300 QKAVSSGLAD AVSFGRKFIA NPDLPRRFAE EIPLAKDDMA TWYSQGPKGY TDYPFADE 358 Sequence Number (ID): 33 MPNLFDPLQL GPITLPNRVI MAPLTRLRGT PDHIPTPLIA EYYAQRASAG LIISEGTPVS 60 PMGVGYAQVP GIWSEQQTEQ WSHITTAVHA AGGRIFAQIW HVGRVSHPLF LNGQQPVAPT ALAPEGFVSL VRPQRPFETP RALDIAEIRS TIADYKRGAQ NAKAAGFDGV ELHGANGYLI 180 DQFLQSGTNH RTDAYGGPVE NRARFMLEAV DAVSEVWGAD RVGMHLAPRG GYMSISDANP 240 SETFGYVATE LGKRGLAFLM SREHEGPDWL TPQLKQQFGG VYIANEGFTY ESANAAVERG 300 DCDAVGFGKL FISNPDLPAR FARQAELTAP IPETFYSHSP EGYIDYPALA 350 Sequence Number (ID): 34 MPTLFDPIRI GDLDLPNRVI MAPLTRSRAV GGGRVPNALM AEYYVQRASA GLILSEATAV 60 TPQGVGYADT PGIWSEEQVA GWKHVTDAVH AAGGRIFLQL WHVGRISDPV FLDGELPVAP SAIAAGGHVS LVRPKRAFVT PRALETEEIP GIVAAYRHGA ENAKAAGFDG VEVHGANGYL 180 LDQFLQDSTN QRNDAYGGSI ENRARLLLEV TDACIAVWGP ARVGVHLAPR GDAHSMGDSD 240 PAATFGYVAR ELGKRGIAFI CSREALGDNR LGPELKRAFG GTYIANEKMT KATAEHVLQA 300 GEADAVAFGQ LFIANPDLPR RLQLDAPLNA PQPETFYHPG AEGYIDYPAL A 351 Sequence Number (ID): 35 MPTLFDTLTL GDLTLKNRIV MAPLTRCRAD EGRVPNAMMA EYYAQRSSAG LILSEATSVT 60 AMGVGYPDTP GIWSDAQVQG WKLITDAVHE AGSRIFLQLW HVGRISDPSY LNGAQPVAPS 120 AVRPAGHISL VRPLKDYDEP RALTLAEIKE VVQAYRQGAI NAKAAGFDGV HIHGANGYLL 180 Firmenich SA 61 DQFLQDSTNL RDDEYGGSLE NRARLMLEVT DACIDVWGKD RVAMHLAPRM DAHDMGDSNR 240 TATFGYVATE LGKRGIAFIS TREHAADDSI TPLIKQLFGG PVIANEKFSK AEANQWLAEG 300 KADAVAFGIP FIANPDLPKR LELDAPLNEP RKELFYGKGP LGYTDYPTLA 350 Sequence Number (ID): 36 MATIFDPIKL GDIELKNRII MAPLTRCRAD AGRVPNALMA EYYVQRASAG LILSEATSVT 60 PMGVGYPDTP GIWSNDQVRG WSNVTKAIHG AGGKIFLQLW HVGRISHPSY LNGETPVAPS 120 AIQPKGHVSL VRPLADYPTP RALETAEIAD IVEAYRVGAE NAKAAGFDGV EIHGANGYLL 180 DQFLQSSTNQ RTDSYGGSLE NRARLLLEVT DAAIEVWGAG RVGVHLAPRA DSHDMGDENR 240 LETFSYVARE LGKRGIAFIC SREKEGDDSI GPQLKQAFGG PYIANERFTK DSANAWLAEG 300 KADAVAFGVP FIANPDLPAR LKADAPLNEA HPETFYGKGP VGYIDYPVL 349 Sequence Number (ID): 37 MATIFDPIKL GDLELSNRII MAPLTRCRAD EGRVPNALMA EYYVQRASAG LILSEATSVT 60 PMGVGYPDTP GIWSNDQVRG WTNITKAVHA AGGKIVLQLW HVGRISHPLY LNGEAPVAPS 120 AIQPKGHVSL VRPLADYPTP RALETAEIAE IVEAYRTGAE NAKAAGFDGV EIHGANGYLL 180 DQFLQSSTNQ RTDNYGGSLE NRARLLLEVT DAAIDVWGAG RVGVHLAPRA DSHDMGDDNL 240 AETFTYVARE LGKRGIAFIC SREKEGADSL GPQLKEAFGG AYIANERFTK DSANAWLAEG 300 KADAVAFGVP FIANPDLPAR LKADAPLNEP RPELFYGKGP VGYIDYPTL 349 Sequence Number (ID): 38 MSYMNFDPKP LGDTNIFKPI KIGNNELKHR VVMPALTRMR AIAPGNIPNT EWAEEYYRQR 60 SQYPGTLIIT EGTFPSAQSG GYPNVPGIWS KEQLAEWKKI FNAIHENKSF VWVQLWVLGR QAWPEVLKKE GLRYDSATDD LYMGEEEKER ALKANNPQHG ITKEEIKQYI KEYVDAAKKA 180 IDAGADGVQI HSANGYLLNQ FLDPISNNRT DEYGGSIENR ARFTLEVVDA VVDAVGAERT 240 SIRFSPYGTF GTMSGGENPG IVAQYAYVIG ELEKRARAGK RLAFIDLVEP RVTDPFLPEF 300 EKWFKEGTNE FIYSIWKGPV LRVGNYALDP DQATLDSKKP NTLIGYGRSF IANPDLVYRL 360 EKGLPLNKYD RNTFYTFTKE GYTDYPSYEE SVAKGYKKEE KKY 403 Sequence Number (ID): 39 MSFVQDFKPI ALADTKLFKP IKIGNNELAH RVVMPPLTRM RATHPGNVPN KDWAVEYYDQ 60 RSKRPGTLII TEGAFPSAQS GGYDNVPGIW SPAQLEQWKK IFAKIHENKS FVWVQLWVLG RQSFADTLAR DGLRYDSASD GVYMDEEQRE RAVKSNNPQH GLTKAEIKQY ISEYVDAAKK 180 SIEAGADGVE IHSANGYLLN QFLDPISNKR TDEYGGSIEN RARFVLEVVD AVTEAIGCDK 240 VGIRLSPYGT FGTMSGGSEP LIVAQFAYVL GELEKRGKAG KRLSFVHLVE PRVTNPFYTE 300 GQGEYTEGTN DFAYSVWKGP IIRAGNLALH PEVVKKMVED DRTLIGYGRF FISNPDIVDR 360 VEKGLPLNKY NRDTFYAMTA NGYLDYPTYD EAVKLGYK 398 Firmenich SA 62 Sequence Number (ID): 40 MPFVKGFEPI SLRDTNLFEP IKIGNTQLAH RAVMPPLTRM RATHPGNIPN KEWAAVYYGQ 60 RAQRPGTMII TEGTFISPQA GGYDNAPGIW SDEQVAEWKN IFLAIHDCQS FAWVQLWSLG 120 WASFPDVLAR DGLRYDCASD RVYMNATLQE KAKDANNLEH SLTKDDIKQY IKDYIHAAKN 180 SIAAGADGVE IHSANGYLLN QFLDPHSNKR TDEYGGTIEN RARFTLEVVD ALIETIGPER 240 VGLRLSPYGT FNSMSGGAEP GIIAQYSYVL GELEKRAKAG KRLAFVHLVE PRVTDPSLVE 300 GEGEYSEGTN DFAYSIWKGP IIRAGNYALH PEVVREQVKD PRTLIGYGRF FISNPDLVYR 360 LEEGLPLNKY DRSTFYTMSA EGYTDYPTYE EAVDLGWNKN 400 Sequence Number (ID): 41 MPFVKDFKPQ ALGDTNLFKP IKIGNNELLH RAVIPPLTRM RAQHPGNIPN RDWAVEYYAQ 60 RAQRPGTLII TEGTFPSPQS GGYDNAPGIW SEEQIKEWTK IFKAIHENKS FAWVQLWVLG WAAFPDTLAR DGLRYDSASD NVYMNAEQEE KAKKANNPQH SITKDEIKQY VKEYVQAAKN 180 SIAAGADGVE IHSANGYLLN QFLDPHSNNR TDEYGGSIEN RARFTLEVVD AVVDAIGPEK 240 VGLRLSPYGV FNSMSGGAET GIVAQYAYVL GELERRAKAG KRLAFVHLVE PRVTNPFLTE 300 GEGEYNGGSN KFAYSIWKGP IIRAGNFALH PEVVREEVKD PRTLIGYGRF FISNPDLVDR 360 LEKGLPLNKY DRDTFYKMSA EGYIDYPTYE EALKLGWDKN 400 Sequence Number (ID): 42 MSFVKDFKPQ ALGDTNLFKP IKIGNNELLH RAVIPPLTRM RALHPGNIPN RDWAVEYYTQ 60 RAQRPGTMII TEGAFISPQA GGYDNAPGVW SEEQMVEWTK IFNAIHEKKS FVWVQLWVLG WAAFPDNLAR DGLRYDSASD NVFMDAEQEA KAKKANNPQH SLTKDEIKQY IKEYVQAAKN 180 SIAAGADGVE IHSANGYLLN QFLDPHSNTR TDEYGGSIEN RARFTLEVVD ALVEAIGHEK 240 VGLRLSPYGV FNSMSGGAET GIVAQYAYVA GELEKRAKAG KRLAFVHLVE PRVTNPFLTE 300 GEGEYEGGSN DFVYSIWKGP VIRAGNFALH PEVVREEVKD KRTLIGYGRF FISNPDLVDR 360 LEKGLPLNKY DRDTFYQMSA HGYIDYPTYE EALKLGWDKK 400 Sequence Number (ID): 43 MTVGLEQSNL FKPITIGKNT LDQRVAFAPT TRFRAADDHT PSDLMLQYYS DRAQAPGSLL 60 ITEATFISPR AGLYPNIPGI WNEKHVQGWK KITDAVHAKG SYMACQFWFL GRVGSPELLK 120 KHGLDLISPS ALYESEESKK AAEAAGNPVR ALTEKEIKGI IYEDYKNAAI NAMEAGFDYV 180 EIHSAHGYML DQFLQPATNQ RTDNYGGSIE KRARIVLEII DLLSDTIGAE KLAIRLSPWA 240 KFQGMKAEQD TVHPITTFSY VVNELQKRAN NGKQLAYLSL VEPRVQGNLD VNTSDIVGSN 300 DFIKKLWKGA ILQSGNYTYD SPEFKLLKAD VNGDNRTMIG FSRYFTSNPD LIDRLKKGLE 360 LTPYVRSLFY ATNNYGYNTF ANYGKELQFD PKKEEKRRPV SLI 403 Sequence Number (ID): 44 Firmenich SA 63 MSSVKISPLK DSEAFQSIKV YPPTTRFRAL EDHTPSDLQL QYYGDRSTFP 60 GTLLITEATF VSPQASGYEG AAPGIWTDKH AKAWKVITDK VHANGSFVST QLIFLGRVAD 120 PAVMKTRGLN PVSASATYES DAAKEAAEAV GNPVRALTTQ EVKDLVYETY TNAAQKAMDA 180 GFDYIELHAA HGYLLDQFLQ PCTNQRTDEY GGSIENRARL ILELIDHLST IVGADKIGIR 240 ISPWATFQNM KAHKDTVHPL TTFSYLVHEL QQRADKGQGI AYISVVEPRV SGNVDVSEED 300 QAGDNEFVSK IWKGVILKAG NYSYDAPEFK TLKEDIADKR TLVGFSRYFT SNPNLVWKLR 360 DGIDLVPYDR NTFYSDNNYG YNTFSMDSEE VDKELEIKRV PSAIEAL 407 Sequence Number (ID): 45 atggaagaag tgaggaacaa gcaggtagta ttcaaggatt atatcaatgg cttccccaag 60 gaatcagaca tgcttctcaa atcttcttcc accatctgcc tcaaacttcc acaaggttct 120 aacggcgttc tcgttaagaa cctttatctc tcctgtgatc cctacatgcg tgctcgcatg 180 accaaaactg aaggcagtta ctttcctcct ttcactcctg gttcgcctat atcaggatat 240 ggagttgcaa aagtccttga ttctgggcat ccagacttaa agaaaggtga tctagtgtgg 300 ggagggactg gatgggagga atacagcatt atcgatgctc ccgagtctct attcaagatt 360 caacatactg atatgcctct ttcctattat acaggcattc tcggtatgcc cggtatgact 420 gcttatattg gtttctatga gatttgtgct ccaaagaaag gagagtatgt atttgtttca 480 gcggcttcag gtgcagttgg tcagctcgtc ggccaatttg caaagttgtc aggatgctat 540 gttgttggga gtgctggtac aaaagaaaag gttgatctcc tgaagaacaa atttggattt 600 gatgaggctt ttaactacaa agaagagcaa gatctaaatg cagctctgaa gaggtacttt 660 cctgatggca ttgatattta ctttgaaaat gttgggggaa agatgttgga ggcagtactc 720 tcaaatatga gattaaatgg tcggatttca gcttgcggaa tgatctcaca gtacaatcta 780 gagcaaccag agggggtgtg taacctgttt ttgctggtag gaaaacgttt gcgcatgcaa 840 gggttcatcg tgagtgatta ctatcacttg tatccaaagt atatggaaat ggtaatgccg 900 ttgataaaac aaggaacaat atcttacatt gaggacattg tggagggact tgagagtgca 960 cccgcggctt tggttgggct gttttctggc agaaatgtcg ggaagcaagt ggtggttgtg 1020 gctcgtgaat ga 1032 Sequence Number (ID): 46 atggaagaag tgaagaacaa gcaggtggta ttgaaggatt acatcaatgg cttccccaag 60 gaatcagaca tgcttctcaa atcttcttcc accatctgcc tcaaacttcc acaaggttct 120 aatggccttc tcgttaaaaa cctttatctc tcttgtgatc cctacatgcg taatcgaatg 180 agcaaatctc aaggcagtta cgttgattca cttactcctg gtttgcctat aacaggatat 240 ggagtagcta aagtccttga ttctgggcat tcagacttca agaaaggtga cctagtttgg 300 ggatggactg gatgggagga atacagcatt atcgatgctc ccgagtctct attcaagatt 360 Firmenich SA 64 caacatactg atatgcctct acaggcattc ttggtatgcc tggtatgacc 420 gcttatgctg gcttctatga gatttgtgct ccaaagaaag gagagtatgt atttgtttca 480 gcggcctcag gtgcagttgg ccagctcgtt gggcagtttg caaagttgtc aggatgctat 540 gttgttggga gtgctggtac aaaagaaaag gttgatctcc tgaagaacaa atttggattt 600 gatgaggctt ttaactacaa agaagagcaa gatctaaatg cagctctgaa gaggtacttt 660 cctgatggca ttgatattta ctttgaaaat gttgggggaa agatgttgga ggcagtactc 720 tcaaatatga gattaaatgg tcggatttca gcttgcggaa tgatctcaca gtacaatcta 780 gagcaaccag agggggtgtg taacctgttt ttgctggtag gaaaacgttt gcgcatgcaa 840 gggttcatcg tgagtgatta ctatcacttg tatccaaagt atatggaaat ggtaatgccg 900 ttgataaaac aaggaacaat atcttacatt gaggacattg tggagggact tgagagtgca 960 cccgcggctt tggttgggct gttttctggc agaaatgtcg ggaagcaagt ggtggttgtg 1020 gctcgtgaat ga 1032 Sequence Number (ID): 47 atggcagaag tggtggagag atcgccggag gtagtgattg taagaaacaa gcaggtgatt 60 ttcaaagatt acgtgaatgg atacccgaaa gaaactgaca tggtggttac ttctgatgca 120 accatccgtt taaagctacc cgagaatgaa agcggcctta ttttaacaaa aaatctatat 180 ttgtcatgcg atccctacat gaggggtcgc atgagcaaga cttccgaagg aagttacgta 240 ccttctttta cacctggttc gcttatatct ggatatggag tcgcaaaagt cttggattca 300 actcaccccg aatacaagaa gggcgacttg atatcgggaa tcatcagttg ggaagaatat 360 agtttgatca aaaatcccga attgtttatc aagattcagc atacggatgt tcccctttcg 420 tactatactg ggatccttgg tatggctggc gtgactgctt atgctggttt ttatgagatt 480 tgttcaccaa agaaaggtga cactgtgttt gtgtcatcag catccggagc cgttggtcaa 540 cttgtaggcc agtttgcgaa actccatggt tgttatgttg ttggaagtgc tggatccaaa 600 gaaaaggttg atctactcaa gaacaaattc gggtttgacg aggcatttaa ctacaaagaa 660 gagcacgatc ttaattccac tttaaagagg tgtttccctg atggtattga tatttacttt 720 gaaaacgttg gtggaaagat gctggatgca gtactatgca acatgagact tcatggccgg 780 attgctgttt gtgggatgat ctcacagtat aaccttaatg aacatcaggg cataaataat 840 cttatcttcg ttatcttgaa acgaatccga atggaaggct tcttggttac tgatcactat 900 cacttgtttc caaagttttt ggaaatggtt ttgcctctca ttcaagaagg caagataaca 960 tatgttgagg acactattga aggccttgag aatgctcctg ctgcacttgt tggcttgttt 1020 tcgggcaaaa atgttggaaa acaaattgtt gatttaactc aagagtaa 1068 Sequence Number (ID): 48 atgggagaaa tggtggagaa caagcagatt gtactgaaag actacgtaag tgggtatcct 60 Firmenich SA 65 aaggagagtg atatggttac aagatgagct tgaatgtacc acatgggtct 120 aatgggattg tggttaagaa tctttatttg tcatgtgatc cttacatgcg ccctcgtatg 180 accaaatcag aaggtggcta tgttgactcc ttcactcctg gtcagcctat tacgggatat 240 ggggtggcga aagtgttgga ttcagggact ccaaagttca agaaaggtga cttggtttgg 300 ggatttaccg gatgggaaga gtatagcctc attacgaaaa cagatacttt gtttaagata 360 gagcacacag atgtgcctct ttcctactac acagggttgt taggtatgcc cggtatgact 420 gcttatgctg gtttctataa ggtggctacc ccaaagaaag gagaatatgt ttttgtttca 480 gcagcatctg gagcagttgg gcaacttgtt ggacagtttg caaagctttt gggctgctat 540 gttgttggga gtgctggaag caaagaaaag gttgaccttt tgaagaataa atttggattt 600 gacgaggctt ttaactacaa ggaagaggaa gacctggctg cagcactaaa aaggtacttc 660 cctgatggca ttgacattta ctttgaaaat gttggaggaa agatgcttga tgcagtgctt 720 gttaacatga ggccccatgg acgcattgct gtgtgtggga tgatctctca gtacaacctt 780 gaaaagcctg aaggcatata caatttaacg tacgttatta tgaagcaact ccgcatagaa 840 ggctttttag tatttgacta ctaccatctt tatcccaaac ttctggagtt ggttctgcca 900 tatataaagg aagggaagat aaattacgtg gaagacatag ctgaaggcct ggagagtgct 960 ccagccgctc tcgttggact tttctctggt cgtaacgttg gtaagcaagt ggtggccgtt 1020 gctcgtgaat ga 1032 Sequence Number (ID): 49 atggcgagtg gtggagaaat gcaagttagc aacaaacagg tgatattcag agactatgtg 60 accggcttcc cgaaagaatc tgacatggaa ttgaccacta ggagcatcac actgaagctc 120 ccacaaggtt ccactgggct tctcctcaag aacctctact tgtcctgcga tccttatatg 180 cgagcccgta tgaccaacca ccataggctc tcttatgtcg actccttcaa gcccggttcg 240 ccaataatcg gttatggagt ggctagagta ttggaatctg ggaatccaaa atttaatcca 300 ggagacttgg tttggggatt tactggttgg gaggaatata gtgtcataac tgcaacagag 360 tctctcttca agattcacaa cactgatgtg cctctctctt actatactgg acttctcggt 420 atgcctggga tgactgctta tgctggtttt tatgagatct gctctcctaa aaaaggagag 480 acggtctacg tttcagcagc atctggagca gtaggtcagc ttgttggcca atttgcaaag 540 ttgactggtt gctatgttgt tgggagtgcc ggaagcaagg aaaaggttga tttgctgaag 600 aacaaatttg ggtttgatga ggctttcaat tataaagaag aagctgacct ggatgctgct 660 ctaaggaggt acttccctga tggtattgac atctactttg aaaatgttgg ggggaaaatg 720 ctggatgcgg tgctgccaaa catgaggcct aaaggccgaa tagcagtttg tgggatgatc 780 tcacagtaca accttgagca gcctgaaggc gtccgtaatt tgatggctct gatcgttaag 840 caggtccgca tggaaggttt catggttttc tcttactatc atctttacgg aaagtttctt 900 Firmenich SA 66 gaaaccgtgc tgccttacat aagattacgt acgtggaaga tgtagttgac 960 ggccttgaca atgctccagc ggctctcatt ggcctctatt ctggccgcaa tgtgggcaag 1020 caggtggtgg ttgtttccag agagtga 1047 Sequence Number (ID): 50 atgacggcga cgaacaagca agtcatattg aaagactacg tgagtggttt ccctacggaa 60 tccgatttcg atttcactac caccaccgtc gaacttaggg ttccggaagg tactaactct 120 gttctagtga agaatctcta cttgtcatgc gatccttaca tgagaattcg catggggaaa 180 cctgatcctt ccactgctgc tcttgctcaa gcttacactc ccggccagcc aatccaaggg 240 tatggagtgt ctagaataat agaatctgga catccagatt acaagaaagg agacttactc 300 tggggtatag ttgcatggga ggagtacagt gttatcactc caatgactca cgcgcatttc 360 aagatccaac atactgatgt tccattatct tattacactg gacttttagg tatgcctggt 420 atgactgcct atgctgggtt ttatgaagtt tgttctccaa aggaaggaga gacagtttat 480 gtgtcagctg catctggtgc tgttggtcag cttgtgggac aacttgctaa gatgatgggc 540 tgttatgttg ttggaagcgc tggaagtaaa gagaaggttg atcttctgaa gaccaagttt 600 gggtttgatg atgcatttaa ctacaaggaa gaatctgacc ttactgctgc cctaaaaagg 660 tgtttcccta atggcattga catatacttt gagaatgtag gaggcaaaat gctagatgca 720 gtgcttgtga acatgaacat gcacgggcgt atcgctgtct gtggaatgat ctcacagtac 780 aatcttgaga accaggaagg tgtacacaac ctatccaaca taatctacaa aagaatccgc 840 attcaaggct ttgtagtgtc tgatttctac gacaaatact caaagttctt ggagtttgtg 900 cttccccaca ttagagaagg gaagataacg tacgtggaag atgtagctga tgggcttgag 960 aaagctcccg aagctcttgt gggactcttc catggtaaga atgttgggaa acaagttgtt 1020 gttgttgctc gtgagtga 1038 Sequence Number (ID): 51 atggcagaag aagtgagcaa caaacaggtc attcttaaaa actatgtcac aggttaccct 60 aaggaatccg acatggaaat caagaatgtc accattaaac tcaaagttcc agaaggttct 120 aatgatgtgg ttgtgaagaa tctttacttg tcttgtgacc cttatatgcg tagccgcatg 180 aggaaaattg agggtagcta tgttgaatcc ttcgctcctg gctcccctat cacgggatat 240 ggagtggcta aagttttgga gtctggtgat ccaaaattcc aaaaaggtga cttagtttgg 300 ggaatgactg gatgggaaga gtatagtatt ataacaccta ctcagactct ctttaaaatt 360 catgacaagg atgtgcctct ttcctactac acaggaatcc tcgggatgcc tgggatgaca 420 gcttatgctg gttttcatga ggtttgctcc cccaagaagg gggaaactgt ctttgtttca 480 gctgcatctg gagcagttgg tcagctcgtt gggcaatttg caaagatgct gggttgctac 540 gttgttggta gtgctggaag caaagaaaag gttgatctgt tgaagagcaa atttgggttt 600 Firmenich SA 67 gacgaagctt ttaactataa gatttaagtg cagctttgaa gaggtacttc 660 cctgatggaa ttgacatcta ctttgagaat gtgggaggga agatgcttga tgcagttctt 720 gtgaacatga aactctatgg ccgtattgct gtgtgtggga tgatttcgca atacaacctt 780 gagcagactg aaggagtgca caacttgttt tgcctcatca caaaacgaat ccgcatggaa 840 ggatttcttg tttttgatta ctatcatctt taccccaaat atttggaaat ggtcattcct 900 caaataaagg caggcaaggt tgtttatgtg gaagatgttg cccatggcct tgaaagtgct 960 cccactgctc tagttggtct cttctctggt cgcaatattg gaaagcaagt cgtgatggtt 1020 tcgcgtgaat ga 1032 Sequence Number (ID): 52 atggggcaac aaaagcagcg taatcgacgt tgggttctgg cctcgcgtcc acatggcgca 60 cctgttccgg agaatttccg tcttgaagaa gatgatgtcg ccacaccggg tgaaggacag 120 gtgttactgc gcacagttta tttgtccctg gacccgtata tgcgtggacg tatgagcgat 180 gagccatctt attcaccgcc tgttgatatt ggcggcgtga tggtcggcgg tacggtgagc 240 cgtgtcgtgg agtcgaatca tcctgattat cagtctggcg actgggtgct gggctacagt 300 ggatggcaag actatgacat atccagtggt gatgatctgg tgaaacttgg cgatcatccg 360 caaaatccat cgtggtcgct gggtgtgcta gggatgccag gctttaccgc ttatatgggc 420 ctactggata tcggtcagcc taaagagggc gaaacgttgg tggtagctgc ggcgacagga 480 ccagtggggg cgacggtggg gcaaatcggc aaacttaaag gttgcagagt ggtgggggta 540 gccggtggcg cggaaaaatg ccgccatgct accgaggtgt taggcttcga tgtttgtctt 600 gatcaccacg cggatgattt tgccgaacaa ctggcgaaag cgtgcccaaa aggtattgat 660 atctattatg aaaacgtggg cggtaaggta ttcgatgcgg tgctaccgtt acttaataca 720 tctgcgcgca ttcccgtctg cggattagtg agcagctata acgctacaga gctaccaccc 780 ggtccggatc gtttacctct gttgatggct acagtgctga aaaaacgtat tcgcttgcaa 840 ggttttatta tcgctcagga ttatggtcac cgcatccatg agtttcagag ggagatgggg 900 caatgggtga aagaggataa aatccactac cgcgaagaaa ttactgacgg tttagagaat 960 gcgccacaga cgtttatcgg cctgctgaag ggtaaaaact tcggcaaagt ggtgatccgc 1020 gtggcgggtg atgattaa 1038 Sequence Number (ID): 53 atggcaccag ttacaaacgg acgaatcatc ttcaactcga tccctacggg ttttccggta 60 cctggagaga cgactatcta cgacaccacg gagaccattg atctcgacac ggcacctctc 120 gatgggggat tcctcctgaa gacactcgag ctgtcggttg acccttacat gcgcggcggg 180 atgcgtgccc ccgagaagaa gtcgtactca gcccctttca ctctaggaca accgcttcgg 240 gggtatggtg ttggtgtcgt tttgaggtct gaaaaccccc aagtgaaggc cggtgatcat 300 Firmenich SA 68 ctttatggat tctttgagca tcgattcgta aagacctgac gggcctccaa 360 gccatcgaga atgcgtacaa ccttccctgg tcggtgttta ttggtgttat aggaatgcca 420 ggcaaaacgg catatatggc ctggaaggag tacgctcatc cgaagcaggg tgaaaccgtc 480 ttcgtctcaa cgggagcagg ccctgttgga tccttcgtca ttcaactcgc caaagccgat 540 ggtctgaaag tcattgcctc tgcgggttcg gaagaaaagg tccaattcat gaaagaggtt 600 ggcgcggacg tagccttcaa ttacaagacc acaaatacgg ctgaagtgct ggagaaagag 660 ggcccaattg atatctactg ggacaacgtt ggcggcgaga cgcttgaagc tgccctgaat 720 gctgcgaacg tcaacgctcg atttattgaa tgcggcatga tctcgggcta caacagtgga 780 ggggcaccag tccgaaacat tttccatgtt atcggcaagt ccatcaccat gaccggtttc 840 atcgtcagcc ggatcgagcc caagtacagc gccgaatttt acaaggaggt acctgccaaa 900 gtggctagtg gagagctcaa atatcgcgaa catgtgtaca atggtctcga gaagctcggc 960 gacgtcatct tggcggtaca aaaaggagag aacaaggcga aggctgttgt ccatgtggct 1020 gatgattag 1029 Sequence Number (ID): 54 atggcatcag ttaccaacgg tcgcgtgctt ttcaactcta ttcccgaagg ctttcccgag 60 cccgggaaga cagtcgtcta tgatacatca gaaaatattg acctcgacac cgtccccttg 120 aacggtggat tcctcctcaa gactctcgac ctatcgatag acccctacat gcgcggtcgt 180 atgcgtgcac cagagaagaa gtcgtattcg ccccctttcc ttctcaacca accaattgac 240 ggctatggtg ttggtgtcgt cctccgctct gagcttcctg aagtgaaagc tggagatcat 300 ctatacggat tcttcaagca tgttcaatat gacgtgcgca cgaacttgga aggcttgagc 360 aaactcccta acgagcacgg gctctcatgg agtgtgtacg tcggtgctgc tggtatgccc 420 ggcaagactg cctatatggc gtggaaggaa tactcgcaag cgaagaaggg ggagactgtc 480 ttcgttagcg ccggtgctgg tcctgttggg tcacttgtca tccaattcgc gaaagctgac 540 ggcctcaagg tcattggttc tgctggatct gatgagaaag tccagttcat gaaggagtgt 600 ggcgctgacg tcgccttcaa ctacaaaact accaatacga aggaggtcct tgagaaggaa 660 ggccccattg acatcttctg ggataatgtc ggcggtgaga cccttgaagc agcactcgaa 720 gctgcgaacg tcaatgcacg attcatcgaa tgcggcatga tctctgggta taacagtgga 780 ggcgcaccca tccgcaacct gttccatgtc gtcagcaagt ccatctccat gcacggcttc 840 atcgtcagcc gtcttgagcc caaatacggg aaggagttct acgagaccat cccacacaag 900 ttggcgagcg gagaactcaa gcatcgtgaa catgtgtttg acgggcttga taaagtcgga 960 gaagcgctcc ttgcggtgca gaagggtacg aataaggcga aggcggttgt taaggtagca 1020 gacgagtag 1029 Sequence Number (ID): 55 Firmenich SA 69 atgaatccta agtataagcc ccatttacgt ttaaaagcgg cgttacaatc 60 aacaaccgga tcgcagtagc accgatgact cattacgctt ctaatgaaga cggtacaata 120 tctgaagcgg agctcgacta catcatcccc cgttcaaaag agatgggaat ggtgattaca 180 gcctgcgcaa atgttacacc ggacggaaaa gcattccccg ggcagccggc catccatgac 240 gattccaaca ttccaggttt aaaaaagtta gcacaagcca ttcaggcaca aggcgctaaa 300 gctgttgtac aaattcatca cggcggtatt gagtgcccgt ctgagctcgt tcctcaacag 360 gatgttgtgg ggccaagtga cgtgtttgat aacggcaaac aaattgctcg cgcattaaca 420 gaagaagaag tggaaaacat tgtgaaggcg tttggagaag cgacaagacg cgccattgaa 480 gccggctttg acggtgtcga aattcacggt gcaaacggct acttaattca gcagttttat 540 tctccgaaaa ccaaccagcg cacggatcgc tggggaggaa gcgatgaaaa acgattagcc 600 ttcccgctcg ctattgtcga tgaagtgaaa aaagccgctt cagaacatgc gaagggtgca 660 ttcttagtcg gctaccgcct gtctccggaa gaacctgaga caccgggatt gacaatgact 720 gaaacttata cgcttgttga tgctttaggg gataaagaat tggattatct tcatatctca 780 ctgatggacg tgaactcaaa agcgcgccgc ggtgcagatc cgactcgcac acgcatggac 840 ttattgaatg aacgtgtcgg aaacaaagtg ccgctgatcg ccgtcggttc catccattcc 900 gctgatgacg cgcttgccgt catcgaaaac ggtattccac tggtcgctat gggacgcgaa 960 attctagttg accctaactg gacggtaaaa gtaaaagaag gccgtgaaaa gcaaatcgaa 1020 acagtgatca aaggcacaga taaagaaaaa tatcatttgc ctgaaccgct atggcaagca 1080 attgtgaaca cacaaggctg ggtgccttat aaagattaa 1119 Sequence Number (ID): 56 atgaatccga aatataatcc tttatttgaa gcttttaccc tgccatccgg tgttacattg 60 aagaaccgca ttacgatggc ccctatgact aactttgctt cccacgaaaa tggcgaagtc 120 agtgacgagg aactggcata ctaccgtgag cgctccggtg gtgtgggagc ggttattacc 180 gcttgtgtgt atgtaactcc agatggtaaa ggatttgtta atgagtttag tgcggacaag 240 gatgagatga ttcctagcct acgtcgtctg gcagatacga ttcatcagga gggcgcgaaa 300 gcgatcctgc aaatttatca tggtggccgt ctgtgtccgc cggatcaaat tccagacgga 360 caaccaatta gtgcaagcgc agtagccgag gaaaaagaag gcgcacctgt gccgcgtgaa 420 atgacatctg acgatatcca ccgcgtcatc cgtgcctatg gcgaagctac tcgccgcgcg 480 attgaagcag gctatgatgg tgtagagctt cacggagcga atggttacct ggttcagcag 540 ttcttctctc cgcattccaa cattcgtacg gatgaatggg gaggaagcct tgaagaacgg 600 ttgacttttc cgctggcggt tgttcacgaa gtgaagaaag tgatcgcaga acatgcgaag 660 cgtccgttca tcttcggata ccgcttgtct cctgaggaag gacacacgcc aggcatcacg 720 ctggatgata cgatggtgct tgtagaccgc ctggcagatg aagggctgga ttacctgcac 780 Firmenich SA 70 atttccgtaa atcatttctt ttccgtgacc gtagtgacga acggtcacgt 840 acggttctca tccatgagaa ggttgggaac cgtgtgccag tcatgggagt tggttcactg 900 aatactccgg atgaggcgct tgcagcactg gagacaggtg taccgcttgt ttcactggga 960 cgtccgttgt tgatggagcc gcaatgggtt cagaaggtgc aaaacggcac tgaagatact 1020 attcgcacga cattatccaa gcaagcccaa caggagctgg tcattcctga ctatttgtgg 1080 ggtgcactga cgaccatccc tggctggatg ccggttacgg actga 1125 Sequence Number (ID): 57 atgaacacag aattactgtt taaacctttt aaggcaggta atttatctct tcccaatcgg 60 attgttatgg cgcctatgac acggaatttt tctcctcaag gtattccagg gcctgaagtg 120 gccgcgtatt atcgtcgccg tgcggaaaat gcagttggat tgattattac ggagggcact 180 gctattaatc atcctgcagc tgtggagcac acaagcattc ctaattttta tggagaggga 240 ttagagggat gggccaaggt agttgaggag gttcatgcgg taggtggcaa gattataccg 300 cagctctggc atgtgggtac ggcccgtaaa ataggtgcag ataatcaacc gaatcccgag 360 gcattgcctg tcggtccgtc cggtatttct cccgctggtg aaaaggtagt cgagccattg 420 acggaggctg agattgcgga tattatctcc gcttatgctc aggccgctgc cgatgcccag 480 cgagtggggt ttgacggtat tgagcttcat ggagcacacg gctatttaat cgatcaattt 540 ttctgggaca aaacgaataa gcgtaccgat caatacggag gcaatttggt ccagcgtact 600 cggtttgcgg tggaggtcat tgaggcttgc cgtcgtgcag tggggccgaa cttcccaatt 660 gtactgcgat tctcccagtg gaagatgtat cactatgaag aaaagctggc acagacacca 720 caggaacttg aacagtttct cactccatta gtgaaggccg gggtggatat attccattgc 780 tcaagccgcc gtttttggga accggaattt gaagggtctg atctaaattt ggcagcttgg 840 accaaaaaga taacaggcaa gccagtgatt actgtgggct cgattggttt ggagaaggcc 900 tttttgagtg atttggaaaa aaataataat cgtcaaaccg atcaatccag tagtgtagag 960 gcaagattag aacaactcgt ggggcaagta gaacgagagg aagctgatct ggttgcggtt 1020 gggcgtgctt tgttggttga tccagcgttt gcggtgaagt tacgtgatca acaaatagaa 1080 gaaattattc cttacagtga tgaagtatta aaaacgttga attga 1125 Sequence Number (ID): 58 atgaacacga tgctgttttc gccgtataca atccgcgggc tgacgctgaa aaaccgaatt 60 gtcatgtcgc cgatgtgcat gtattcgtgc gacacgaaag acggcgccgt acgcacgtgg 120 cataaaatcc actacccggc tcgcgctgtc ggccaagtcg gcttgattat cgttgaagcg 180 accggcgtga cgccgcaagg tcgcatttct gaacgcgact taggcatttg gagcgatgac 240 catatcgccg ggcttcgcga actcgttggg cttgtgaaag agcatggggc ggccatcggc 300 atccagcttg cccatgcggg gagaaaatcg caagtgccgg gagagatcat cgctccgtca 360 Firmenich SA 71 gccgtcccgt ttgatgattc ccaaaagaaa tgacgaaagc cgacattgaa 420 gaaacggtgc aagcgttcca aaacggcgca cggcgcgcga aggaagccgg ctttgacgtc 480 attgaaatcc atgccgccca cggctacctc attaacgaat ttttatcgcc gctctccaac 540 cggcgccaag acgagtacgg cggctctccg gaaaaccgtt accgtttctt gggcgaggtg 600 atcgacgctg tccgcgaggt gtgggacgga ccgctttttg tccgcatctc ggcgtccgac 660 taccatccgg acgggctgac ggccaaagac tatgtcccat acgccaagcg gatgaaagaa 720 caaggagtcg acctcgtcga tgtcagctcc ggcgctattg ttccggcgcg catgaacgtc 780 tatcccggct accaagtgcc atttgccgaa ctgatccgcc gtgaagcaga catcccgacc 840 ggcgctgtcg gcctcattac gtccggctgg caagcggaag aaattttgca aaacggccgc 900 gccgatctcg tctttttggg gcgcgagctg ctgcgcaacc cgtattggcc atacgccgcg 960 gcgagagagc tgggcgcaaa aatctcggcg cccgtccaat atgagcgcgg ctggcggttt 1020 taa 1023 Sequence Number (ID): 59 atgaccggca aactcttttc cccgatttcc gtcggcccgc tgtccctgcc caaccgcatc 60 ttcatggcgc cgctgacgcg catgcgcagc cgtgagcccg gtgatgtgcc ggtgctgccg 120 ctgatggccg aatactatcg ccagcgcgcc aatgcggggc tgatcatcag cgaggctacg 180 caagtgtcgc cgcagggcaa gggctacatg ggcacgccgg gcatccacag cgccgaacag 240 gttgaggcct ggcgggacat cacccgcgcc gtgcacgatg agggcggcca tatcgccatc 300 cagttgtggc atgtcggccg ggtttcgcac cactcgctgc aaccggaccg gcaattgccg 360 gtgtccgctt cggccatccc ctacgaaaac aagaccacca tccgtggcga ggacagcaag 420 ccgcagcgcg tcgcctgcga cacgccccgc gcgctgcgca cagatgaaat tcccggcctg 480 atcgaaacct accgccaggc cacgattaac gcccgcgagg ccggtttcga cctggtggaa 540 gtgcacgccg cccacggcta tctgctgcac cagttccagt ccgccgtcag caaccaccgc 600 gacgacgcct acggcggctg cctggaaaac cgcgcccgcc tgacgctgga agtggtcgac 660 gcctgcatcg ccgcctggga tgccgcccac gtcggcatcc gcatctcgcc gctgggcacc 720 ttcaacgggc tggatgactc ggccggtctg gaaatgggcc tgtatctggc cgaacaactg 780 gccaagcgca acattgccta cctgcacctg tccgaaccgg actgggcggg cggcccggcg 840 cactccgacg agttccgcca ggcgctgcgc gaccgcttcc ccggcgtcat catcggcgcg 900 ggcaactaca cggtggaaaa ggcggaggcc ttgctggcca agggctacat cgatgccgcc 960 gccttcggtc gcccctatat cagcaatccc gacctggccg agcgtttccg caccggtgcg 1020 gcgctggcga tgctgaatcc ggccacgctc tatggcggcg gcgaggaagg ttacaccgac 1080 tacccggcgc tggcctga 1098 Sequence Number (ID): 60 Firmenich SA 72 atgtccggca aactttttac attggtggtt ttaccctgcc caatcgcgtg 60 ctcatggcac cgctgacgcg catgcgctcc agtcagccgg gtgatgtacc caatgaactg 120 atgcaggcct attacgtgca gcgcgccagc gccgggatga tcattgcaga ggccacgcag 180 atttcgccac agggcaaggg ttacatggat acccccggta tttacagtgc cgaacaggtg 240 gcgggctgga agaagatcac gcaggccgtg catgaggcca acggccatat ctgcctgcag 300 ctctggcatg tcggccgtgt ctcgcatcac tcgctgcagc cggaccagca gttgccggta 360 tcggcctctg ccatacccta tgaaaaccgc acgacagtgc gtggtgagga tggcaaggtc 420 aagcgtgtgg cctgtgatac tccacgtgca ctggagctga ccgaaattcc cggactgatc 480 gaggactacc gacgtgcgac agtgaatgcg cgcgaggccg gtttcgacat ggttgaagtg 540 catgccgccc atggctatct gctgcaccag ttccagtcgg ccaccagtaa ccagcgtaat 600 gacgcttacg gcggctcact ggagaaccgt gcgcggctga cactggaggt gctggatgcc 660 gtgattggtg catgggatgc agcgcatgtc ggcatccgca tctcgccgct gggcattttc 720 aacggcctcg atgatcgtga cggcctggac atggggctgt atctggccga gcagtttgcc 780 ctgcggggga ttgggtacct gcacctgtcc gagccggact gggccggtgg tccggtactt 840 aacgaggaat tccgtgtcgc cctgcgtgcc cgcttccccg gcatcatcat tgcggcaggc 900 aactattcgg tggaaaaggc cgaaggattg ctggagaagg gcttgattga tgctgcggca 960 ttcggtcgac cgttcattgc caatccggat ttgccgcagc gcttgcgcaa gggtgccgag 1020 ctcaacgcgg tcaatgcagc gaccctctat ggtggcggtg cagaaggcta tacggattat 1080 cctgcgttgg cctga 1095 Sequence Number (ID): 61 atgtccggca agttgttcac cccgttcagc tcgggttcct tcaccttccc caaccgcgtt 60 atcatggcgc cgctgacgcg tatgcgcgct tcgcagccgg gtgacattcc caacgagctg atgcagacct attacgtgca gcgcgccagc gccggcctca tcatcgccga ggccacgcag atctccccgc agggcaaggg ctatatggac actccgggga tttattccgc ggagcaggtg cagggctggc gcaagatcac ccaggccgtg catgaggccg gtggccatat cgccctgcag ctctggcatg tgggtcgtgt ttcgcatcac agcctgcagc ccgaccagca actgccggtg tccgcttctg ccattcccta ccagaaccgc accacggtcc gtggtgaaga cggcaagccc acgcgcgtgg attgcgatac cccacgtgcg ctggaactgt ccgaaatccc cggtgtgatc gaagactacc gccgcgccac cgtgaattcg cgcgaagccg gtttcgacat ggtggaagtg catgccgcgc atggctatct gctgcaccag ttccagtccg ccgaaagcaa caagcgtgaa gacgcctatg gtggttcgct ggaaaaccgt gcccgcctga cgctggaagc cctggatgcc gtgatcggtg cctgggatgc caagcatgta ggtatccgca tttccccgct gggcaccttc aacggcctgg acgacaagga cggcctggaa atggcgctgt atctcacgcg tgaattcacc Firmenich SA 73 aagcgcggta tcgcctacct gagccggact gggccggcgg tccggcgcat 840 ggcgacgaat tccgccaggc cctgcgcgac gctttcccgg gcaccatcat cggtgccggc 900 aactacacgg tggaaaaatc ggagatgctg ctggccaagg gctttatcga tgccgccgcg 960 tttggtcgtc cctttattgc caatccggac ctgccggtgc gtctgcagaa gggcgctgag 1020 ttgaacaatg tggtggcggc tacgctgtat ggcggtggcg ccgaaggcta tacggattat 1080 ccggcgctgg cctga 1095 Sequence Number (ID): 62 atgaaactct tgcaaccgct gcaaatcggc cccctcaccc tgcccaaccg tgtcttcatg 60 gcgcccctca cccgcctgcg cagcctggag ccgggcgatg tacccaccac gctgatgggc 120 gagtactacc gtcagcgcgc cagtgcgggc ctgatcatca ctgaagccac gcagatctcc 180 ttccaggcca agggctattc tggctcgccc ggcattcata gcgccgaaca gatcgctgcc 240 tggaagcaca tcaacgaagg cattcatgcc gatggcggcc acagcgccgt gcaggtctgg 300 cacaccgggc gggtgtcaca cacttctctg caacctggcg gcgaagcgcc agtggcccct 360 tcggcacttc cggcaggtgc gcgcactacc ctgcgtgacg agcaaggcga cctgatacgc 420 gtagaaacat ccgcgccgcg ggcgctcagc gaagcggaaa ttgccggtat tgtcgccgac 480 ttcggcctgg ccgcgatcaa cgcccgtgaa gccgggttcg acttcatcga gctgcatgcg 540 gcccatggtt acctgctgca ccagttcctt accccaagtg ccaaccagcg cgaagaccgt 600 tacggcggca gcgtcgaaaa ccgcgcacgt attgtgctgg aggcggtgga cgcggccgtt 660 gccaactgga gcgccgagcg cgtcggcatc cgcgtgttcc cgttgggtgg tttcaatggc 720 gtggacaatg gcgaagacca ggaagccgcc ggcctgtatc tgatccgcga gctggccaag 780 cgcaacctcg cctacctgca cctctccgag cctgactggg ccggtggcaa gccattgcgt 840 gacgaattcc gccaggcaat ccgcgcggct tacccgggcg taatcatcgc ggccggtgct 900 tacaccgccg agaaaggcga agacctgatc gggcgtggcc tgatcgatgc cgtggcgttc 960 gggcgcagtt acatcgccaa cccggacctg gtcgagcggc tgcggctcca ggcgccgttg 1020 aacgagcacc gggcgcagtt cgactatgcc aatgggcctg aagggtatac ggattatccg 1080 ttcctgaagc aggcttag 1098 Sequence Number (ID): 63 atgtcatctg aaaaactgta ttccccactg aaagtgggcg cgatcacggc ggcaaaccgt 60 atttttatgg caccgctgac gcgtctgcgc agtattgaac cgggtgacat tcctaccccg 120 ttgatggcgg aatactatcg ccaacgtgcc agtgccggtt tgattattag tgaagccacg 180 caaatttctg cccaggcaaa aggatatgca ggtgcgcctg gcatccatag tccggagcaa 240 attgccgcat ggaaaaaaat caccgctggc gttcatgctg aaaatggtca tatggccgtg 300 cagctgtggc acaccggacg catttctcac gccagcctgc aacctggcgg tcaggcaccg 360 Firmenich SA 74 gtagcgcctt cagcacttag cgtacttctc tgcgcgatga aaatggtcag 420 gcgatccgtg ttgaaacatc catgccgcgt gcgcttgaac tggaagagat tccaggtatc 480 gtcaatgatt tccgtcaggc cattgctaac gcgcgtgaag ccggttttga tctggtagag 540 ctccactctg ctcacggtta tttgctgcat cagttccttt ctccttcttc aaaccatcgt 600 accgatcagt acggcggcag cgtggaaaat cgcgcacgtt tggtactgga agtggtcgat 660 gccgggattg aagaatgggg tgccgatcgc attggcattc gcgtttcacc aatcggtact 720 ttccagaaca cagataacgg cccgaatgaa gaagccgatg cactgtatct gattgaacaa 780 ctgggtaaac gcggcattgc ttatctgcat atgtcagaac cagattgggc ggggggtgaa 840 ccgtatactg atgcgttccg cgaaaaagta cgcgcccgtt tccacggtcc gattatcggc 900 gcaggtgcat acacagtaga aaaagctgaa acgctgatcg gcaaagggtt aattgatgcg 960 gtggcatttg gtcgtgactg gattgcgaac ccggatctgg tcgcccgctt gcagcgcaaa 1020 gctgagctta acccacagcg tgccgaaagt ttctacggtg gcggcgcgga aggctatacc 1080 gattacccga cgttgtaa 1098 Sequence Number (ID): 64 atgtccgctg aaaagctgtt taccccactg aaagtgggtg ccgttactgc cccaaaccgc 60 gtgtttatgg ccccacttac ccgtctgcgc agcatcgagc cgggcgatat cccaacgcca 120 ttgatgggtg agtattaccg ccagcgcgcc agcgcgggcc tgattatctc cgaagccacg 180 cagatttctg ctcaggcaaa aggctacgcc ggtgcaccgg gtctgcacag cccggaacag 240 atcgccgcgt ggaaaaaaat caccgcaggc gtgcatgctg aagatggccg tattgcggtt 300 cagctgtggc acaccggtcg tatctcacac agcagcatcc agcctggcgg tcaggcgccg 360 gtttctgcct ctgccctgaa cgccaatacc cgcacttccc tgcgcgatga aaacggtaat 420 gcgatccgcg tcgacaccac cacgccacgc gcgctggagc tggacgagat cccgggtatc 480 gtgaatgatt tccgtcaggc cgtcgccaac gcccgggaag cgggcttcga cctggttgag 540 cttcactctg cgcacggtta cctgctgcat cagttcctgt ccccgtcttc caaccagcgt 600 accgaccagt acggcggcag cgttgaaaac cgcgcgcgtc tggtgcttga agtggtggat 660 gctgtctgta atgagtggag cgcagaccgc attggtattc gtgtctcccc gatcggtact 720 ttccagaacg tcgacaacgg tccgaacgaa gaagcagacg cgctgtatct gattgaagag 780 ctggcgaaac gcggtatcgc ctatctgcac atgtccgaga cggacttggc aggcggcaag 840 ccttacagtg aagccttccg tcagaaagtg cgcgagcgct tccacggcgt gattatcggg 900 gcgggtgcgt atacggcaga aaaagccgag gatttgatcg gtaaaggcct gatcgacgcc 960 gtggcctttg gccgtgacta cattgctaac ccggatctgg ttgcccgttt gcagaaaaaa 1020 gccgaactga acccgcagcg tcctgaaagc ttctatggcg gcggcgcgga aggttatacc 1080 gactaccctt cactgtaa 1098 Firmenich SA 75 Sequence Number (ID): 65 atgaagactg ctaaactgtt ctctcctttg aaggttggcg cgctcacttt gccaaaccgc 60 gtatttatgg caccactgac tcgcttacgc agtattgagc caggtgatat cccaacccct 120 ttaatggcgg aatattatcg tcaacgggcc agtgccggtt tgattatcac cgaagcaacc 180 cagatctctt tccaggcaaa aggctacgcg ggagcaccgg ggttacacac tcaggagcag 240 ttgaacgcgt ggaaaaaaat cactcaggcg gtgcatgagg aggggggaca tattgccgtg 300 cagctgtggc atgttggacg catttcgcac agtagcttgc agcccggcca acaagcgcca 360 gtagcgcctt cagctattgc cgctgatacc cgcaccaccg tgcgcgatga aaacggtgcc 420 tgggtgcgcg ttccctgctc caccccgcgc gccttggaaa cagaagagat cccgggcatc 480 attaatgatt tccgtcaggc caccgccaat gcgcgcgaag cgggttttga ctatatcgaa 540 ctccatgccg cccatggtta tttgctgcat caatttatgt ctccggcctc aaatcagcgt 600 accgaccaat acggtggtag cattgaaaac cgtacccgtc tgacactgga ggtggttgac 660 gccaccgctg cccaatggag tgctgaacgt attggtatcc gtatctcccc attagggccg 720 ttcaatggtc tggataatgg tgaagatcag gaagaagcgg cactgtatct gattgatgaa 780 ttgaacaaac ggcatatcgc ctacctgcac atctccgagc cagattgggc cggtggtaaa 840 ccttactcag aggcgttccg tgatgcggtt cgtgcgcgct tcaaaggggt tattatcggt 900 gcgggtgcct ataccgccga gaaggccgaa gagttgattg agaaaggctt tattgatgcg 960 gtagcttttg gtcgcagcta tatctctaac ccagatttag tcgctcgcct acaacagcat 1020 gccccactga atgagcctga tggcgaaaca ttctacggcg gcggtgctaa gggctacact 1080 gattacccaa cgctgtga 1098 Sequence Number (ID): 66 atgaagacag caaaattgtt ctctcccctg aaagtcggtg catttacgct acctaaccgc 60 gtatttatgg ctcctctgac tcgcttacgc agcattgagc caggagatat tcctacacca 120 ttaatggccg aatattatgc ccagcgcgcc agcgccggtt tgatcatcac cgaagcgacg 180 caggtttctt ttcaggccaa aggctacgcc ggtgctccgg gtttacacac tcaggaacag 240 ttggaaggat ggaaaaaaat cactcaagcg gtacatgaaa aacaaggaca tatcgccgta 300 caactttggc atgtcggtcg tatttctcac catagtttgc agccaaacca acaggctccg 360 gtagcccctt cggccattgc cgccgacacc cgcaccacca ttcgtgatga aaatggtgat 420 tgggttcgtg ttccttgctc tacaccacgc gcgctggaat tacaggaaat cccagcgatt 480 gttgatgatt ttaggaacgc gacggccaat gcccgcgaag ccggttttga tttcattgaa 540 atccatgcgg cacacggcta tttattacac caattcatgt ctccggcatc caaccagcgc 600 accgatgctt acggcggtag cattgaaaac cgcactcgcc tgacgttgga agtggttgat 660 gcgaccgccg cagaatgggg cgcggaacac attggtatcc gtatttcacc acttggccca 720 Firmenich SA 76 ttcaatggcc tggataacgg gaagatgcgg cgctgtatct gattgatgaa 780 ctcaacaaac gtaaaattgc ttatttacat atctctgagc cagattgggc gggtggaaaa 840 ccttacaccg acgctttccg cgatgccgta cgggcgcgct tcaatggcat tatcgtcgga 900 gccggtgcct atacggccga aaaagccgaa accctgattg aaaaaggctt tattgatgcg 960 gttgcctttg gccgcagcta tattgccaac ccagatctgg tcgaacgcct gcaacaacaa 1020 gcgccactga atacaccaga cggcgacacg ttctatggtg gtggagcaaa aggctatacc 1080 gactacccga ctttatcgtg a 1101 Sequence Number (ID): 67 atgacctcgc tcttcgaccc cctcaagatc ggcgacatcc agcttgccaa ccgcatcgtc 60 atggcgccgc tgacgcgcaa ccgctccccg ggtgcggtac cgaacacgct gaacgcggcc 120 tattacgagc agcgcgcctc ggccggcctc ctgatcaccg aagcaaccgc catctcccac 180 cagggccagg gctatgccga cgtgccgggc ctctacaagc cggaagccct tgaaggctgg 240 aagcaggtca ccgatgccgt gcacaaggct ggcggcaaga ttgtcgtgca gatgtggcat 300 gtcggccgga tctcgcatga cacgctgcag ccgaacggcg gcaagccggt cgccccgtcg 360 gcgatccgcg ccaagtcgaa gacctacctg atcaatgccg atggcacggg cagcttcgcc 420 gagacctccg agccacgcgc gctggaaaag gacgagcttc cgggcatcat cgaagactat 480 cgccgtgccg cccgcgccgc cgtggatgcc ggtttcgatg gcgtcgaaat ccacgccgcc 540 aacggctacc tgctcgacca gttcctgcgt tccggcagca acgagcgtac cgacgaatat 600 ggcggctcga tcgaaaaccg cgcccgcctg ctcttccagg tcgtcgacgt catcaccaaa 660 gaaatcggcg ccggccgcac cgcgatccgc atctcgccgg tgacgccggc aaacgattcc 720 tccgatccga acccgcagcc gctcttcacc tatgtcgtgg aaggcctcgc caaatacgac 780 ctcgcctata tccacatcat cgaaggcgcg accggcggtc cgcgtgatca ccagcagggc 840 gacgcgccgt tcgactatgc ggcactgcgc gcagcctatc aggctgccgg cggcaaggcg 900 gcctggatgg tcaataacgg ctacaaccgc gaactcgcca tcgacgcggt ggaagaaggc 960 aaggccgacc tcgtcgcctt cggcaagctc ttcatcgcca atccggacct cgtggagcgc 1020 ctgaagaacg acaccgtgct gaacccgccg gaccaggcca ccttctacgg cggcggcgcc 1080 aagggctata cggactatcc ggccctggaa aacgtcgcct ga 1122 Sequence Number (ID): 68 atgacaaaac tgttcgaacc ggcacaggca ggcgatatcg cactggcaaa ccgcatcgtt 60 atggcacctc tcacccgcaa ccgttcaccg ggtgctattc caaacaatct gaacgctgcc 120 tattatgaac agcgcgccac tgctggcctt atcgtcacgg aaggcacgcc cgtatcgcag 180 caaggccagg gttacgccga tgttcccggc ctgtataagc aggaagccat cgatggctgg 240 aaagcggtga ccgacggcgt tcacaaggct ggcggcaaga tcgtcgcgca gatttggcac 300 Firmenich SA 77 gttggccgta tctcgcacac ccgcatggcg gccagccggt tgctccttca 360 ccgatcaagg ccaattccaa gacctacatc atcaatgatg atggcacggg cagcttcgca 420 gaaacatccg agccacggga aatctcgctg caggaaatcc ccgtcattct tgaggattat 480 cgcaccggcg cgcgggccgc gatcgacgcc gggttcgacg gcgtggaaat ccatgccgcc 540 aacggctatc tgatcgacca gtttctgaaa tcaggcacca accagcgcac ggacgcttac 600 ggtggctcga ttgaaaaccg cgcccgcttc ctgctggaag tcgtggacac tgtgacgaag 660 gaaatcggcg ctggccgcac cggcattcgc ctgtctcccg tcacaccggc caacgacatt 720 ttcgaagcag atccccagcc gttgttcgaa tatgtcgcac gcgaactcgg cagccgtggc 780 ctcgccttca tccacgtcat cgaaggcgcg acaggtggac cgcgtgattt caagcagggc 840 gacaagccat tcgactatga tgcgctgaaa gctgcctaca ccaatgccgg gggcaaaggc 900 ctgtggattg ccaacaacgg ctacgaccgc gaaagcgcga ttgccgcgac cgaaagcggc 960 aaggtcgatg cggtcgcctt cggcaaagcc tttatttcca atccggacct ggtgcagcgt 1020 ctgaaggaaa atgcggctct caacgagcca aaccagcaga cattttatgg tggtggtgca 1080 gaaggctaca ccgactatcc cgctttggca taa 1113 Sequence Number (ID): 69 atgtccgatc tcttcgaacc gaccaggcc ggcgacatcg cgctcgccaa ccgcatcgcc 60 atggcgccgc tcacgcgcaa ccgttccccg ggcgaggcgc cgaacgatct caacgtcacc 120 tactaccagc agcgcgccac cgcaggcctg atcattaccg agggtacgcc gatcacccat cagggccagg gctatgccca tgtgccgggg ctctacaagc ccgaggcgct ggaaggctgg aaaaaagtca cggatgccgt ccacaaggct ggtggcaaga tcgtcacgca gatctggcat gtcggccgcg tgtcccacac ctcgctgcag cctggcgaag gcaagccggt ggcgccctcg gcgatcacgg cgaagtccaa gacctatatc atcaatcccg atggcagcgg cgcgtttgcc gatacctccg agccgcgagc gctctcgctt gaggagattc ccggcattct tgaggactat cgcgtggccg cgcgtgcagc cgtggatgcc ggtttcgacg gtgtcgaaat ccacgccgcc aatggctatc tgcttgacca gttcctgcgc tccggctcca accagcgcac cgacgcctat ggcggctcga tcgagaaccg cacgcgcctg acgctggaag tcgcagccgt ggtggccaag gaaatcggcg gcggtcgcac cggcatccgc atctcgcccg tcaccccggc caatgatgtc ttcgaccccg agccgcagcc gctgttcaat catctggttt cgaagctcgc ggggctcgac ctggccttca tccacgtcat cgaaggcgcg accggcggtc cgcgcgactt caagcagggc gacaagcctt tcgattggga cgagttgcgc aagacctatc gcgacgccgg cggcaagggc gcctggatgg tcaacaacgg ctatgacaag gcatccgcca ccgaagccgt tgccagtggc cgggccgaca ttgtcacctt cggcaagctg ttcatcgcca atcccgacct ggtgcgccgc ttcaaggagg atgcgccgct gaacgagccg aacaaggcca ccttctatgg cggcggcgcc Firmenich SA 78 gaaggctata cggactatcc taa 1113 Sequence Number (ID): 70 atgccgactc ttttcgaccc cttgactttg ggcgacctgc aatctccaaa ccgtgttctg 60 atggcaccgc taacgcgtgg ccgcgcgacc cgcgagcacg tgcctaccga gctgatgatc 120 gagtattaca cccagcgtgc cagcgcgggc ctgatcatca ccgaagccac cggcatcacc 180 caagaaggcc taggctggcc ctatgcgccc ggcatttgga gcgatgaaca ggtcgaggcc 240 tggaagccgg tgacccaggc cgtgcatgag gcaggcggac ggatcattct tcagttgtgg 300 catatgggcc gtaccgttca ttccagcttt ctcggcggag ccaagccagt atcgtcctcg 360 gccacccgtg cgccgggaca ggcgcacacc tacgaaggca agcaagacta cgacgaggcg 420 cggcctttgt cggcggatga aatcccgcgg ctattgaacg attacgaaca cgcagcgaaa 480 aacgccatgg ccgcaggctt cgacggcgtg cagatccatg ctgccaatgg ttacctaatc 540 gaccagttcc tgcgcgacaa cagcaacgtt cgcggggacg cctacggggg ttcaatcgag 600 aaccgcatcc gtctattggt cgaagtcacc cggcgcgtgg cggagaccgt aggtgccgaa 660 aaaacgggcg tgcggctgtc acccaacggt gattcccaag gcgtcaacga cagcaatccg 720 gagccgctgt tcagcgccgc ggccaaggcc ttggatgaga tcggcatcgc tcatctggag 780 ttgcgcgaac cagggtatga aggcaccttc ggcaaggccg accggccgcc cgtgcacccg 840 gtcatccgcc aggcgttcag ccgtacgctg attctcaact ctgactacac tttggaaacg 900 gctcaggctg cactagccac cggagaagcg gacgcgatca ccttcggccg cccgttcctg 960 gccaaccctg acctgcctca caggtttgcc gagagactgc cgctgaacaa ggacgtgatg 1020 gagacttggt atagccaggg gcccgaaggt tatgtggact accccaccgc tgaccaaaag 1080 tag 1083 Sequence Number (ID): 71 atgcctaccc tgttcgatcc catccgtctt ggtgcagtta ccgctaaaaa tagaatttta 60 atggctcctc tcacgcgcgg ccgtgctacg cgtgatcatg tgccaaccga tattatgatt 120 aaatattatg cccagcgtgc gagtgccggt ctgattattt cagaggcaac aggcattagc 180 caagaagggt taggttggcc ttatgcgccg ggcatatgga atgaagcgca aacccaagca 240 tggattccta tcactcaggc cgtgcatgat gcgggcggtc ttatctttgt tcaattatgg 300 catatggggc gcttggtgcc ttctagtgtc agcggtatgc aacctgtttc agcctcggca 360 accaaggcac cggatttggc gcatacctat gaaggtaaaa aaccttttga tgttgctcgg 420 ccactagaaa ttgctgaaat tccacgcttg cttgatgatt atgagcgcgc aacacgtaat 480 gcactatccg ctggatttga tggggttcaa attcacgcgg ctaatggcta tttaattgat 540 gaattcttac gagatggtac taatcttcgt aaggatgctt atgggggtac tccagaacat 600 cgtatccgtt tattacgtga agtgaccgag cgtgttatta gtgttatcgg tgcggaccgt 660 Firmenich SA 79 acctcggttc ggctttctcc attcaaggtg cctcggatag ccatcctgaa 720 aatatttttt taccagccgc acggatgctt tctgatctgg ggattgcttt tcttggattg 780 cgggaaggaa cgcctgaagg tacctttgga aggacagacc agcctaagct ttccccaaaa 840 attcgtgaag tcttcaatcc accgcttatt cttaatcaag attacaatct tgaaactgcg 900 caggaggctc ttgattccgg tgtagccgat gcgatcagtt ttggacgtct ctttatctct 960 aatccagatc ttccaaggcg cttttttgaa ggctcaccgc ttattaaaga caatattgct 1020 acatggtata cccaaggtgc cgaaggctat accgactatc cccttatcgg taatgaaata 1080 cccgcataa 1089 Sequence Number (ID): 72 atgcctagct tgtttgatcc catccgcttc ggcgctttta ccgcaaaaaa tagaatttgg 60 atggcgcctc tgacccgtgg ccgtgccacg cgcgatcatg tccccactga aataatggcc 120 gaatattatg cccagagggc aagcgccgga ctgattattt cagaagcgac tggcattagt 180 caggaaggtt tgggctggcc ttatgctccg ggaatctgga gtgatgccca agtagaagcc 240 tggctgccga ttacgcaggc cgtgcatgat gccggcggtc ttatctttgc ccagctatgg 300 catatgggac gtatggtgcc gtctaatgtc agtgggatgc agcctgttgc gccttctgcc 360 agtcaggcac ccggattggg gcatacctat gatggtaaaa agccttatga tgttgcccgc 420 gctttgcgat tggatgaaat tccgcgtctt cttgatgatt atgaaaaggc tgcccgtcat 480 gccttgaagg ccggttttga tggcgtacag atccatgccg ctaatggtta tttgattgac 540 gaatttatac gggatagcac caaccatcgt catgatgaat atgggggtgc agttgaaaac 600 cgtattcgtt tgctgaaaga cgtcaccgaa cgagttattg caaccattgg gaaagagcgg 660 acggccgtta ggttatcacc gaatggtgaa atacagggga cggttgatag tcatcccgaa 720 caggttttta taccggcggc caaaatgttg tctgatttgg atattgcctt tttagggatg 780 cgagaagggg ctgttgatgg cacctttggc aaaacagatc agcccaaatt atcgcctgaa 840 atccgaaaag ttttcaaacc gcctttggtt cttaatcagg attatacttt tgaaaccgcg 900 caagctgctc ttgattccgg tgtggccgat gccatcagtt ttggaaggcc ttttatcggt 960 aatcctgatt tgccacggcg tttctttgag aaagcccccc ttaccaaaga tgtgattgag 1020 acttggtata cccaaacccc caagggatat acggattatc ctttgcttgg ggattaa 1077 Sequence Number (ID): 73 atgaccagcc tgtttgagcc gattgaactg ggaagcattt acgccaaaaa cagaattctc 60 atggcgccgc tgacacgcgg tcggagcacc cgtgatcatg tgcccacccc catcatggcc 120 gaatattacg cgcaacgggc cggagccggt ctgatcatct cagaagcgac cgggatcagc 180 cgcgaaggtc ttggctggcc gtatgcgccg ggcctgtggt cgcaggaaca ggtggaagcc 240 tggaagccca tcaccgccgc agttcacgcc aagggcggaa agattgtggc ccagctctgg 300 Firmenich SA 80 catatgggtc ggatggttca acgggccagc aacctgtgtc ctgctcggcg 360 acaaaagcgc ctgaagccct ccatacgtac gatggcaagc aggctcccga agtcgcccgc 420 cctctcacca aggaggacat tgcccgcatc ctgaacgact acgaaaatgc tgctcgcaat 480 gcccttcagg caggctttga cggtgtgcag attcatgccg ccaacggtta tctgatcgac 540 gaatttctgc gggacggcac caatcatcgt tccgacgaat atggcggttc gccggaaaac 600 cgcatccgct tcctgcgtga agtcaccgaa cgcgtgatcg caacgattgg cgcgcacaaa 660 acgtcagtaa ggctgtcccc caatggcgat acgcagggct gcatcgacag tcatccagag 720 caggtttttg tgccggcctc aaagctgctg aatgacctcg atatcgcttt ccttgaactg 780 cgcgagcccg gaccgaacgg cacgttcggc aagaccgacc agcccaagct gcatggtccg 840 atccgcgaag tcttcaggaa gccgctggtt ctgaatcagg actacacacg ggaagaagcg 900 atcgagacag tcgctaccgg tgttgcggac gccatttcgt ttggtcggcc tttcctcgcc 960 aatccggacc tcgtgcgtcg tctggaagac aatctgcccc agaacaagga cgatatccgc 1020 acctggtact cgcagggtgc agaaggctat acggattatc cgcttgctcg ctga 1074 Sequence Number (ID): 74 atgacgaccc tgttcgaccc gatcaagctt ggcgcaatcg ccgctcccaa ccggatcatc 60 atggcaccgc tgacgcgcgg tcgttcgagt cgtggccatg ttcccagcgc cctgatggcg 120 gaatattacg cgcagcgggc cagtgccggt ctcatcatca ccgaagcgac cggcatttcg 180 caggaaggcc ttggctggcc ctatgcaccg ggcatctggt cggatgagca ggtggaggcc 240 tggaagccca tcgtgcgcgc ggttcatgac aagggcggcc ggatcgtcat gcagctctgg 300 cacatgggcc ggatggtgca ttcgaatgtg accggcctgc agcctgtctc ggcgtcgccg 360 acgaccgcgc cgggcgaagc gcacacctat gatggcaaga agccctacga gcaggcgcgt 420 gcgctcgaca tttcggaaat cccgcggctt ctggcggatt acgagaacgc gacccgcaac 480 gcgctggcgg cgggcttcga cggtgtccag atccatgcag ccaacggcta cctgatcgac 540 gaattcctgc gcgacagcac caacaagcgg accgatgcct acggcggcga accggaaaac 600 cgcatccgtc tgctgcgcga agtgacggag cgggtgatct cggtcgccgg tgccgatcgc 660 acggctgttc gtctcagccc gaacggcgag acgcagggca cgatcgacag caatccgatc 720 tcggtcttcg tgccggcagc gaagatgctg tacgatctcg gcctcgcctg gctcgaactt 780 cgcgagcccg gcccgaacgg cacgttcggc cggaccgacc agccaaagct gtcgccgcag 840 atccggcagg tcttcaaggc gccgctggtc ctgaactcgg actacacgct cgaggaagcc 900 gagacggcgg tgctggaaga tcgggccgat gcgatcagct tcggacgcaa gtttctggcc 960 aatccggacc tgccgcaccg cttcaagtcc ggtctgccgc ttaacaggga cgagatgaag 1020 acgtggtatt cccaggggcc gcagggctac gtcgattatc ctgccgcctc ctaa 1074 Sequence Number (ID): 75 Firmenich SA 81 atgccaaccc tgttcgatcc ggtcccattc acgcgaaaaa ccggatcgtg 60 atgtccccgc tgacgcgcgg acgtgctgac aaggaggccg ttccgacccc catcatggcg 120 gaatactacg cccagcgcgc cagtgccggg ctgatcatca cggaagccac gggtatctcc 180 cgcgaaggtc tgggctggcc gttcgcaccg ggaatctggt ccgatgcgca ggtcgaagcc 240 tggaagccga tcgtggccgg tgtgcatgca aagggcggaa agatcgtctg ccagctctgg 300 cacatgggcc gcatggtcca ctcgtccgtg accggaacgc agcccgtctc gtcctccgcc 360 accacggccc ccggcgaggt ccatacctat gaaggcaaga agccgttcga gcaggcccgc 420 gcaatcgatg ccgcggatat cagccgtatt ctgaacgact atgagaacgc cgcccgcaat 480 gcgatccgcg ccggcttcga cggggtgcag atccacgccg ccaatggcta cctcatcgac 540 gagttcctgc gaaacggtac gaatcaccgc acagatgaat acggcggcgt ccccgaaaac 600 cgcatccgtt tcctgaagga agtcaccgag cgcgtgatcg ctgccatcgg tgccgaccgc 660 acaggcgtgc gcctgtcccc caacggcgat acgcagggct gcatcgacag cgcacctgag 720 acggtctttg tcccggcggc aaagctgctt caggatctgg gcgtggcctg gctcgaactg 780 cgcgaacccg gcccgaacgg caccttcggc aagacggacc agcccaaact gtccccgcag 840 atccgcaagg tgttcctgcg cccgctggtg ctcaatcagg actatacgtt cgaggcagca 900 cagaccgcgc tggcagaagg gaaggctgat gcgatcgcct tcggtcgcaa gttcatctcg 960 aaccccgacc tgccggagcg cttcgcccgc ggcatcgccc tgcagccgga tgatatgaaa 1020 acctggtaca gtcagggccc cgaaggatac acggactacc cgtccgccac ctccggcccc 1080 aactaa 1086 Sequence Number (ID): 76 atgcctagcc tgttcgattc catcgacctt ggcgcagttc acgctgccaa tcgcatcatc 60 atgtcgcccc tgacgcgtgc gcgtgccacc gagggagctg ttcctacgcc tctcatggtt 120 gaatattacg cccagcgcgc tggcgccggt cttattattt cggaagccac aggaatttca 180 cgagaaggtc ttggctggcc ctgggctcca ggaatctgga gtgcagagca ggtggccgcc 240 tggaagccga tcaccaaggc cgttcatgag cgtggtggga aaattgtatg ccagctttgg 300 catatgggcc gtatggttca ttcgtctgtg acagggcttc agccggtctc ggcgtctccg 360 acgactgctc ccgggcaatc ccatacttat gagggcaaga agccctatga agaagcccgc 420 gagcttcgag ttgatgaaat tcctcgtatt ctggctgatt atgagaatgc ggcacggaat 480 gcgattgaag ccgggtttga cggtgttcag atacacgctg cgaatggcta tctgatcgac 540 gaattcctgc gtgatggaac caaccatcgc aaggacgagt acggtggggc cccagagaat 600 cggatccgtt tgcttcgtga agtgacagag cgcgttgtgg ccacgatcgg tgcggatcgt 660 acaagcgtgc gtctatcgcc aaatggtgac acgcagggca ccgatgacag cgcgccggaa 720 aaggttttcg tgcccgctgc gaaggttttg caggatctgg gcgtggcatg gcttgaactg Firmenich SA 82 cgtgagccgg ggcctgaagg aagactgacg aaccgaagct gtcccctgaa 840 attcgtaagg tgtttagtcg tcctctggtc ctcaatcagg attatacgct tgaggatgct 900 cagaaggctg tctcttccgg tctggccgat gctgtgagtt ttgggcgcaa atttattgca 960 aacccggatc tccctcgccg ctttgctgaa gaaatccctt tggcgaagga cgacatggcg 1020 acatggtaca gtcagggccc aaagggttac acggactacc ccttcgcgga tgaataa 1077 Sequence Number (ID): 77 atgccgaacc tcttcgaccc gctccaactc ggccccatca cgctccccaa ccgcgtcatc 60 atggccccac tcacgcgcct gcggggcacg cccgaccaca tccccacgcc cctcatcgcg 120 gagtactacg cccagcgcgc ctccgccggc ctcatcatct ccgaaggcac gcccgtcagc 180 cccatgggcg tcggctacgc gcaggtcccg ggcatctggt cggagcaaca gactgagcag 240 tggtcgcaca tcaccaccgc cgtccacgcc gccggcggcc gcatcttcgc gcagatctgg 300 cacgtcggcc gcgtctcgca cccactcttc ctcaacggcc agcagcccgt tgcgcccacc 360 gctctcgcgc cggagggctt cgtctcgctc gttcgccctc agaggccctt tgagacgccc 420 cgcgcgctcg acatcgccga aatccgcagc accatcgccg actacaagcg cggcgctcag 480 aacgccaagg ccgccggctt cgacggcgtc gaactccacg gcgccaatgg ctacctcatc 540 gaccagttcc tgcagtcagg caccaaccac cgcaccgacg cctacggtgg cccggtcgaa 600 aaccgcgccc gcttcatgct ggaggcagtc gatgccgtct ccgaggtctg gggcgccgac 660 cgtgtcggca tgcacctggc cccgcgcgga ggatatatga gcatctccga cgccaacccc 720 tccgagacct tcggctacgt cgctactgag ctcggcaagc gcggcctcgc cttcctcatg 780 tcccgcgagc acgaagggcc tgattggctc acgccacagc tcaagcagca gttcggcggc 840 gtctacatcg ccaacgaggg cttcacctat gagagcgcaa acgccgccgt cgaacgcggc 900 gactgcgacg ccgtcggctt cggcaagctg ttcatctcca accctgatct gcccgcacgc 960 tttgcccgcc aggcagaact cacggctccc atcccggaaa ccttctactc ccacagcccc 1020 gagggctaca tcgactaccc cgcactcgcc taa 1053 Sequence Number (ID): 78 atgcccacac tctttgaccc gatccgtatc ggcgacctcg accttcccaa ccgcgtcatc 60 atggcgcctc tgacgcgttc gcgcgcagtg ggcggcggcc gcgtgcccaa cgcgttgatg 120 gccgaatact atgtacagcg cgcttcagcg ggcctgatcc tgagcgaagc cacggccgtg 180 actccgcaag gcgtgggtta tgccgacacc ccgggcatct ggtcggaaga acaagtggct 240 ggctggaagc acgttaccga cgccgtgcac gccgccggcg gccgcatctt cctgcaactg 300 tggcacgtgg gccgcatctc cgacccggtc ttcctcgacg gcgaactgcc ggtggcaccc 360 agcgcgatcg cggccggcgg ccatgtcagc ctggtgcgcc ccaagcgcgc ctttgtcacc 420 ccgcgcgcgc ttgaaaccga ggaaatcccg ggcattgtcg ccgcctaccg gcacggcgcg 480 Firmenich SA 83 gagaacgcca aggccgccgg gttgaagtgc acggcgccaa tggctacctg 540 ctcgatcaat tcctgcaaga cagcaccaac cagcgcaacg atgcctacgg cggctcgatc 600 gaaaatcgcg cccggctgct gctggaagtc acggatgcct gcatcgcggt ttggggtccg 660 gcgcgcgtgg gcgtgcacct ggccccgcgc ggcgatgccc acagcatggg cgactccgac 720 cccgccgcca ccttcggcta tgtggcacgc gaactgggca agcgcggcat tgccttcatc 780 tgctcgcgcg aagcgctcgg cgataaccgc ctggggccgg aactgaagcg ggccttcggc 840 ggcacctata tcgccaacga aaaaatgacc aaggccaccg ccgagcacgt cttgcaggcc 900 ggcgaagccg acgcagtggc cttcggccag ctcttcatcg ccaacccgga cctgccgcgc 960 cgcctgcaac tggatgcgcc gctcaacgcg ccgcagccgg aaaccttcta ccatcccggc 1020 gccgaaggtt atatcgatta ccccgcgctc gcctga 1056 Sequence Number (ID): 79 atgccaactt tatttgatac cctcaccctg ggtgatttaa ctctgaaaaa ccgtattgtg 60 atggcgcctt taacccgctg tcgcgccgac gaaggccgtg tgcccaatgc catgatggct 120 gagtattatg cccagcgcag cagcgcaggt ttaattttat ccgaagccac atcagtcaca 180 gctatgggtg tgggttaccc tgacacaccg ggtatttggt ctgacgccca agtgcaaggc 240 tggaagctga tcactgacgc agtgcacgaa gcgggcagcc gtattttcct gcagctgtgg 300 catgtaggtc gtatttccga tccatcttac ttaaatggcg cacaacctgt agcaccaagc 360 gcagtgcgtc cggccggtca tatcagcctg gtacgtccgc tgaaagatta tgacgaacca 420 cgggctttaa ctctggctga aattaaagag gtagtacaag cctatcgtca gggcgctatc 480 aacgccaaag ctgctggttt tgatggtgtg catatacatg gtgccaatgg ttatttactc 540 gaccagtttt tacaggacag cactaattta cgtgacgacg aatacggtgg ttccttagaa 600 aaccgtgccc gtctgatgct ggaagtgaca gacgcctgta ttgacgtctg gggcaaagac 660 agagtcgcca tgcatttagc gccccggatg gatgctcacg atatgggtga ttccaatcgc 720 acagccactt ttggttatgt cgccacagag ctgggtaaaa gaggtatagc ttttatctct 780 acccgtgaac atgcagctga cgacagcatc acgccgctga tcaaacagct gtttggtgga 840 ccagtgattg cgaatgaaaa attcagcaaa gcagaagcga atcagtggct ggccgaaggt 900 aaagccgacg cagtagcctt tggtattcct tttattgcca acccggattt accaaaacgc 960 ttagagctgg atgccccact caacgagcca cgcaaagaac tgttttacgg taaaggcccg 1020 ttaggttata ccgattatcc aaccttagcc tag 1053 Sequence Number (ID): 80 atggcgacta ttttcgaccc catcaaactc ggcgacatcg agttgaagaa ccgcatcatc 60 atggccccgc tcacccgctg ccgcgccgac gcaggtcgcg tgcccaacgc tctgatggcc 120 gaatattacg tgcaacgcgc ctccgccggc ctgatcctca gcgaagcaac ttcggtcacg 180 Firmenich SA 84 ccgatgggcg tgggctaccc ggcatctggt ccaacgacca ggtgcgcggc 240 tggtccaacg tcaccaaggc gatccacggc gctggcggca agatcttcct gcaactgtgg 300 cacgtgggcc ggatctccca cccgtcgtac ctgaacggcg aaaccccggt ggcgcccagc 360 gcgatccaac ccaagggcca cgtgagcctg gtgcgtccgc tggccgacta cccgacccca 420 cgcgcactgg aaaccgctga aatcgccgac atcgtcgagg cgtaccgcgt cggtgccgag 480 aatgccaagg ctgccggttt cgatggcgtg gaaatccacg gcgccaacgg ctacctgctc 540 gaccagttcc tgcaaagcag caccaaccag cgcaccgaca gctacggcgg ctccctggaa 600 aatcgtgccc gcctgctgtt ggaagtgacc gacgcggcca ttgaagtctg gggcgccggc 660 cgggttggcg tgcacctggc accgcgcgcc gactcccatg acatgggtga cgagaaccgc 720 ctggaaacct tcagctacgt ggctcgcgag ctgggcaaac gtggcatcgc cttcatctgc 780 tcccgtgaaa aggaaggcga tgacagcatc ggcccgcaac tcaagcaggc tttcggcggc 840 ccgtacatcg ccaatgaacg cttcaccaag gacagcgcca atgcctggct ggccgagggc 900 aaggccgatg ccgtggcctt cggagtgccg ttcattgcca acccggacct gccagcacgc 960 ttgaaagccg atgcaccact gaacgaagca catccggaaa ccttctatgg caaagggccg 1020 gtggggtaca tcgattaccc tgtgctctga 1050 Sequence Number (ID): 81 atggcaacta ttttcgatcc gatcaaactg ggcgacctcg agctgtccaa ccgcatcatc 60 atggccccgc tgactcgctg ccgcgccgac gaaggccgcg tacccaacgc actgatggcc 120 gagtactacg tgcaacgtgc ctccgccggc ctgattctca gcgaagccac ttcggtgacg 180 ccgatgggcg tcggctatcc ggacaccccg ggcatctggt ccaacgatca ggtacgcggc 240 tggaccaaca tcaccaaagc cgtacacgct gccggcggca agatcgtcct gcaactttgg 300 cacgtcggcc gcatctcgca cccgttgtac ctgaacggcg aagcaccggt cgcgccgagc 360 gccatccagc ctaaaggcca cgtcagcctg gtgcgtccac tggccgatta cccgactcca 420 cgcgccctgg aaaccgctga aatcgccgag atcgtcgagg cctaccgcac cggtgccgag 480 aacgccaagg ccgccggttt cgacggcgtg gaaatccacg gcgccaacgg ctacctgctc 540 gaccagttct tgcaaagcag caccaaccag cgcaccgaca attacggcgg ctccctggaa 600 aaccgtgcgc gtctgttgct ggaagtgact gatgccgcga tcgacgtctg gggcgccggc 660 cgtgtcggtg tgcacctggc accgcgcgcc gactcccacg acatgggcga cgacaacctc 720 gccgagacct tcacctatgt tgctcgcgag ctgggcaagc gtggcatcgc cttcatctgc 780 tcccgcgaga aagaaggcgc cgacagcctc ggcccacaac tgaaagaagc ctttggcggc 840 gcgtacatcg ccaacgagcg tttcaccaag gacagcgcca atgcgtggct ggctgaaggc 900 aaggctgacg ctgtagcgtt cggcgtgcca ttcattgcca acccggacct gccggcacgc 960 ctgaaagccg atgccccgct gaacgagccg cgtcctgagc tgttctatgg caaaggcccg 1020 Firmenich SA 85 gtcggctaca tcgactaccc 1050 Sequence Number (ID): 82 atgtcgtaca tgaactttga ccctaagcca ttgggagaca ccaatatctt caagccaatc 60 aagatcggta acaatgagct aaaacacaga gtagtcatgc cagcattgac tagaatgaga 120 gccattgcac caggaaacat cccaaacact gaatgggccg aggaatacta cagacaacgt 180 tctcaatacc ctggtaccct tattatcacg gaaggtactt tcccttctgc gcaatcaggt 240 ggttacccaa atgtgccagg tatctggtcc aaagagcaat tggctgaatg gaaaaagatc 300 ttcaatgcaa tccatgagaa caaatcgttc gtgtgggtgc aattgtgggt tctaggtaga 360 caagcatggc cagaagtgtt gaagaaggaa ggtttgcgtt acgatagtgc taccgatgac 420 ttgtacatgg gtgaagaaga aaaagagcgt gccttaaagg ctaacaaccc acagcacggt 480 atcaccaagg aagaaatcaa gcagtacatc aaggagtacg tggatgctgc caagaaagcc 540 atcgatgcag gtgcagacgg tgtgcaaatc cattctgcca acggttactt gttgaaccag 600 tttttggacc ctatttctaa caacagaacc gacgagtacg gtggatcgat cgagaaccgt 660 gcgagattca ctttggaagt ggtcgatgcc gttgtcgatg cagttggtgc cgaaagaacc 720 tccatcagat tctctccata cggtactttt ggtaccatgt ccggtggtga gaaccctggc 780 atcgttgctc aatatgcata cgtcattggt gagttggaaa agagagctag agctggcaag 840 agattggcgt tcatcgattt ggtcgagcct cgtgtgaccg acccattcct accagaattc 900 gagaagtggt tcaaggaagg taccaacgaa ttcatctact ctatctggaa gggtccagtt 960 ctcagagttg gtaactatgc tttggaccca gatcaagcca ctctcgactc taagaagcct 1020 aacactttga tcggttacgg tagatccttc atcgccaacc cagacttggt gtaccgtttg 1080 gaaaagggtt tgccattgaa caagtatgat agaaacacct tttacacatt cactaaggaa 1140 ggttacaccg attacccaag ctacgaagaa tccgtcgcaa agggttacaa gaaagaggaa 1200 aagaagtact aa 1212 Sequence Number (ID): 83 atgtcttttg ttcaagattt caaaccaatt gcactagctg acactaagct tttcaagcca 60 atcaaaattg gtaacaatga attggcacac cgtgtggtta tgccaccttt gaccagaatg 120 agagctactc atccaggcaa tgttcctaac aaggactggg ctgttgagta ctatgaccaa 180 cgttctaaaa gacctggaac tttgataatc actgagggtg ctttcccatc agcacaaagt 240 ggtggttacg acaatgtacc aggtatctgg tctccagcac aacttgaaca atggaaaaag 300 atcttcgcca agattcacga gaacaagtct tttgtctggg ttcaactttg ggttttagga 360 agacaatctt ttgctgatac gttggcaaga gatggccttc gttatgattc tgcttccgat 420 ggagtttaca tggacgaaga gcaacgtgaa agagctgtga agagcaataa cccacaacat 480 ggtttgacca aggctgaaat taaacagtac attagcgaat acgtcgatgc cgccaagaag 540 Firmenich SA 86 tccattgaag caggtgccga attcacagtg ccaacggtta cctattaaac 600 caattcttgg accctatttc caacaagaga accgatgaat atggtggatc tatcgagaac 660 agagctcgtt tcgtgctgga agttgtcgat gctgtcaccg aggctatcgg ttgcgacaaa 720 gttggtatca gattatctcc atatggtact ttcggtacta tgtctggtgg ttctgagcca 780 ttgatcgttg ctcaatttgc ctatgtattg ggtgaattgg aaaagagagg aaaggctggg 840 aaacgtctat cattcgttca ccttgtcgaa cctcgtgtga caaatccatt ctacactgaa 900 ggccaaggtg agtacaccga aggcaccaat gactttgcat actctgtctg gaaaggtcca 960 atcatcagag ctggtaactt ggctctacac ccagaagttg ttaagaaaat ggtcgaagac 1020 gacagaactc tgataggtta cggtagattt tttatctcaa atcccgatat cgtcgaccgt 1080 gtggaaaaag gtttgccatt gaacaagtac aacagagata ctttttacgc catgacagct 1140 aatggttacc ttgactaccc aacttatgat gaggcagtta agcttggtta caaatag 1197 Sequence Number (ID): 84 atgccatttg taaaaggttt tgagccgatc tccctaagag acacaaacct ttttgaacca 60 attaagattg gtaacactca gcttgcacat cgtgcggtta tgcccccatt gaccagaatg 120 agggccactc accccggaaa tattccaaat aaggagtggg ctgctgtgta ttatggtcag 180 cgtgctcaaa gacctggtac catgatcatc acggaaggta cgtttatttc ccctcaagcc 240 ggcggctatg acaacgcccc tgggatttgg tctgatgagc aggtcgctga gtggaagaat 300 atctttttag ccatccatga ttgtcagtcg ttcgcgtggg tacaactttg gtctttaggc 360 tgggcatcct tcccagacgt attggcaaga gacgggttac gctatgactg tgcatctgac 420 agagtgtata tgaatgctac gttacaagaa aaggccaaag atgcgaataa tctcgaacat 480 agtttgacta aagacgacat taaacagtat atcaaggatt acatccatgc ggctaagaat 540 tctatcgcgg ctggcgccga tggtgtagaa attcatagcg ccaatgggta cttgttgaat 600 cagttcttgg atccacattc taataagagg accgacgaat acggcggaac gatcgaaaac 660 agggcccgct ttacactgga ggttgtcgat gctcttatcg aaactatcgg tcctgaacgg 720 gtgggtttga ggttgtcgcc gtacggcact tttaacagta tgtctggggg tgctgaacca 780 ggtattatcg ctcaatattc gtatgttttg ggtgaattag agaagagggc aaaggctggt 840 aagcgtttgg cctttgtgca cctcgttgaa ccacgtgtca cggacccatc gttggtggag 900 ggcgaaggag aatattccga gggtactaac gattttgcct actctatatg gaagggtcca 960 atcatcagag ctggtaatta cgctcttcat ccagaagtgg ttagagaaca agtaaaggat 1020 cccagaacct tgataggcta tggtagattc ttcatctcta acccagattt agtctaccgt 1080 ttagaagagg gcctgccatt gaacaagtat gacagaagta ccttctacac catgtccgcg 1140 gaaggttata ccgactaccc aacatatgaa gaggcagtag atttaggttg gaacaagaac 1200 tga 1203 Firmenich SA 87 Sequence Number (ID): 85 atgccatttg ttaaggactt taagccacaa gctttgggtg acaccaactt attcaaacca 60 atcaaaattg gtaacaatga acttctacac cgtgctgtca ttcctccatt gactagaatg 120 agagcccaac atccaggtaa tattccaaac agagactggg ccgttgaata ctacgctcaa 180 cgtgctcaaa gaccaggaac cttgattatc actgaaggta cctttccctc tccacaatct 240 gggggttacg acaatgctcc aggtatctgg tccgaagaac aaattaaaga atggaccaag 300 attttcaagg ctattcatga gaataaatcg ttcgcatggg tccaattatg ggttctaggt 360 tgggctgctt tcccagacac ccttgctagg gatggtttgc gttacgactc cgcttctgac 420 aacgtgtata tgaatgcaga acaagaagaa aaggctaaga aggctaacaa cccacaacac 480 agtataacaa aggatgaaat taagcaatac gtcaaagaat acgtccaagc tgccaaaaac 540 tccattgctg ctggtgccga tggtgttgaa atccacagcg ctaacggtta cttgttgaac 600 cagttcttgg acccacactc caataacaga accgatgagt atggtggatc catcgaaaac 660 agagcccgtt tcaccttgga agtggttgat gcagttgtcg atgctattgg ccctgaaaaa 720 gtcggtttga gattgtctcc atatggtgtc ttcaacagta tgtctggtgg tgctgaaacc 780 ggtattgttg ctcaatatgc ttatgtctta ggtgaactag aaagaagagc taaagctggc 840 aagcgtttgg ctttcgtcca tctagttgaa cctcgtgtca ccaacccatt tttaactgaa 900 ggtgaaggtg aatacaatgg aggtagcaac aaatttgctt attctatctg gaagggccca 960 attattagag ctggtaactt tgctctgcac ccagaagttg tcagagaaga ggtgaaggat 1020 cctagaacat tgatcggtta cggtagattt tttatctcta atccagattt ggttgatcgt 1080 ttggaaaaag ggttaccatt aaacaaatat gacagagaca ctttctacaa aatgtcagct 1140 gagggataca ttgactaccc tacgtacgaa gaagctctaa aactcggttg ggacaaaaat 1200 taa 1203 Sequence Number (ID): 86 atgtcatttg taaaagattt taagccacaa gctttaggtg acaccaacct attcaaacca 60 atcaagatcg ggaacaatga acttttgcac cgtgctgtca ttcctccatt gaccagaatg 120 agagctcttc accctggtaa tatcccaaac agggactggg cagtcgaata ctacacccaa 180 cgtgctcaaa gacctggtac catgattatc actgaaggtg ccttcatatc cccacaagcc 240 ggcggttacg ataacgctcc aggtgtttgg tcggaagaac aaatggtgga atggaccaaa 300 atcttcaacg ctattcatga aaagaaatcg ttcgtttggg ttcagttatg ggttttgggt 360 tgggctgctt tcccagacaa tcttgccaga gatggtttgc gttacgattc agcttctgac 420 aacgttttca tggatgccga gcaagaagct aaggccaaga aggccaacaa cccacaacac 480 agcctaacca aggacgaaat caagcaatac attaaggaat acgtccaggc tgccaagaac 540 tctattgctg ctggtgccga tggtgttgaa attcacagtg ctaacggtta cttgttaaac 600 Firmenich SA 88 cagttcttgg accctcattc accgatgaat atggtggatc tattgaaaac 660 agagctcgtt tcaccttgga agttgttgat gctcttgtcg aagccattgg tcatgaaaaa 720 gttggtttga gattgtcccc atacggtgtt ttcaacagta tgtctggtgg tgccgagacc 780 ggcattgttg cccaatatgc ttacgttgct ggtgaattag aaaagagagc taaagccgga 840 aaacgtttag cttttgttca tttggttgaa cctcgtgtaa ctaacccatt cttgactgaa 900 ggggagggtg aatacgaagg aggtagcaac gattttgttt actccatctg gaagggccca 960 gtcattagag ctggtaattt tgctctccac ccagaagtcg ttagagaaga agttaaggac 1020 aagagaacct tgatcggtta cggtagattc ttcatttcta acccggattt ggttgatcgt 1080 ttggaaaaag gtctacctct gaacaaatat gacagagata ctttctacca gatgtctgct 1140 catggttata ttgactaccc cacctatgaa gaagctctca aattaggctg ggacaaaaag 1200 taa 1203 Sequence Number (ID): 87 atgactgtcg gattggaaca atcgaattta tttaaaccga ttactattgg taaaaataca 60 ctggatcaaa gggtagcttt cgctcctaca acaagattcc gtgctgcaga tgatcatact 120 ccaagcgact tgatgctaca atactattct gatagagcac aagctcctgg ttcgttgctc 180 attacggaag ccactttcat ttctcctcgc gctggcttat accctaatat tcctggcatt 240 tggaatgaga aacatgttca aggatggaaa aagattactg atgcagtaca tgctaaagga 300 agctatatgg cgtgtcaatt ttggttctta ggaagagttg gatccccaga gcttttgaaa 360 aagcatggct tggatttgat atctccctct gctttatatg aaagcgaaga gtctaagaag 420 gctgcagaag ctgcaggcaa tcctgtgaga gcattgactg aaaaggaaat caagggcatt 480 atttatgaag attacaagaa tgcagcaatc aatgctatgg aagctggatt tgattatgtg 540 gaaattcata gtgcacatgg atacatgctt gatcaattct tacagcccgc tacgaatcaa 600 agaacagata actatggtgg ttctattgag aagcgtgcaa gaatcgtgct tgagattatc 660 gaccttttaa gcgatacaat tggtgctgaa aagcttgcaa tcagattgtc tccttgggcc 720 aaattccaag gaatgaaagc tgaacaagat actgtgcatc ctattaccac atttagttat 780 gtggtgaatg agcttcaaaa acgtgcaaac aatggtaaac agcttgctta tctttccctt 840 gtggaaccta gggtccaagg aaacttggat gtcaacacat ctgacattgt tggttccaac 900 gactttataa aaaaattatg gaaaggagcc attttgcaga gtggtaatta tacttatgac 960 agtcctgagt ttaagttatt gaaggctgat gtcaatggtg acaaccgtac tatgattgga 1020 ttctcgagat attttacatc aaatccagat ttaattgata gattaaagaa gggtcttgag 1080 cttactcctt acgttcgttc tttgttctat gctactaaca actatggtta taacactttc 1140 gcaaattatg gcaaggaatt gcaatttgat cccaaaaaag aagaaaagag acgtcctgtt 1200 tctttgatct ga 1212 Firmenich SA 89 Sequence Number (ID): 88 atgtcttcag tcaaaatttc tccattgaag gattctgaag cattccagtc tatcaaagtt 60 ggtaacaaca ctcttcaaac caagattgtc tatccaccaa ctactagatt tagagcttta 120 gaagaccaca ctccttctga tttgcaattg cagtactatg gcgacagatc cactttccca 180 ggtactttgc ttatcactga agctactttt gtctctcctc aagcctctgg ttatgaaggt 240 gctgctccag gtatttggac tgacaagcac gctaaagcat ggaaggttat tactgataaa 300 gttcatgcca acggttcttt cgtttcaacc cagttgattt ttttgggaag ggttgcagat 360 ccagctgtta tgaagacccg tgggttgaat ccagtttctg cctctgctac ttatgaaagt 420 gatgccgcta aagaagctgc cgaagcagtt ggtaaccctg ttagagcttt gactacccaa 480 gaagtcaagg atcttgttta cgagacttac accaacgctg ctcagaaggc catggatgct 540 ggtttcgact atattgaact ccatgctgct cacggctacc ttttagatca atttttgcaa 600 ccatgcacca atcaaagaac tgatgaatac ggtggatcca ttgagaacag agccaggtta 660 attcttgagt tgattgacca tttgtctacc attgtcggtg ctgacaagat tggtatcaga 720 atctctccat gggctacttt ccaaaacatg aaggctcaca aggacactgt tcacccattg 780 actactttct cttacttggt ccacgaattg caacagagag ctgacaaggg tcaaggtatt 840 gcctacattt ctgtcgttga gcctcgtgta agtggtaacg tcgacgtctc tgaagaagac 900 caagctggtg acaacgaatt tgtctccaag atctggaagg gtgttatctt gaaggcaggt 960 aactactcct acgatgctcc agagttcaag acattgaagg aagatatcgc tgacaagcgt 1020 acattagttg gcttctccag atacttcacc tcgaatccta acttggtttg gaaattgcgt 1080 gatggaattg acttggtgcc atatgacaga aacacgttct acagtgacaa taactatggt 1140 tacaatacct tttctatgga ttccgaagag gttgataaag aattagaaat caagagagtt 1200 ccttcggcca ttgaagcttt gtaa 1224 Sequence Number (ID): 89 atggaggaag ttcgtaataa acaagtggtc ttcaaagatt acattaacgg cttcccgaaa 60 gaaagcgaca tgctgctcaa atccagctct accatctgtc tcaaactgcc gcagggctct 120 aacggcgttc tggtaaaaaa cctgtacctg tcctgtgacc catatatgcg tgctcgtatg 180 accaaaactg aaggcagcta ctttcctccg ttcaccccgg gtagcccgat ctctggttat 240 ggtgttgcga aagtgctgga ctccggtcat ccagacctga agaaaggtga tctggtttgg 300 ggtggcaccg gctgggagga atatagcatc attgacgctc cggaatctct gtttaaaatt 360 cagcataccg atatgccgct gtcttattac actggcattc tgggcatgcc gggtatgacc 420 gcttatattg gtttttatga aatctgcgca ccgaagaaag gcgagtacgt tttcgtgtcc 480 gctgcatccg gtgctgttgg ccagctggtt ggtcagtttg ctaaactgtc tggctgctac 540 gttgtaggtt ctgctggtac taaagaaaaa gtagatctcc tgaagaacaa attcggtttt 600 Firmenich SA 90 gatgaggcgt ttaactataa gacctgaacg ctgcgctgaa gcgttatttc 660 ccggacggca tcgacatcta ttttgaaaat gtaggcggta aaatgctgga agcggtgctg 720 agcaacatgc gtctgaacgg tcgcatctcc gcgtgcggta tgatcagcca gtacaacctg 780 gaacagccgg aaggtgtttg caacctgttc ctcctggtgg gcaaacgtct gcgcatgcag 840 ggcttcatcg tttctgatta ttaccacctg tacccaaaat acatggagat ggttatgccg 900 ctgatcaaac aaggtaccat cagctacatt gaagatatcg ttgaaggcct ggaatccgcg 960 ccagcagcgc tggttggcct gttctctggt cgtaacgttg gcaaacaggt cgttgtagtc 1020 gctcgtgaat ga 1032 Sequence Number (ID): 90 atggaggaag taaagaacaa gcaggtagtc ctgaaagact acatcaacgg cttcccgaaa 60 gaatccgata tgctcctgaa atcttcctct accatctgcc tgaaactgcc acaaggttct 120 aacggcctcc tggtgaaaaa cctgtatctg tcctgcgacc cgtacatgcg caaccgcatg 180 agcaaatccc agggtagcta cgtcgactct ctgaccccgg gcctgccgat caccggctac 240 ggtgttgcta aggtcctgga ctccggtcac tccgatttca aaaagggtga cctcgtttgg 300 ggttggacgg gctgggagga atattccatc attgatgctc cggaatctct gttcaaaatt 360 cagcacactg acatgccgct gtcctactat accggcatcc tgggtatgcc gggcatgacc 420 gcgtatgcgg gtttctacga aatctgtgct ccgaagaaag gcgaatatgt ctttgtctct 480 gcggcttccg gtgcggtcgg tcagctggtt ggtcagtttg ccaaactgtc cggctgttac 540 gtcgttggta gcgcaggcac caaagagaaa gtggacctcc tgaaaaacaa gttcggtttc 600 gacgaagcgt tcaattacaa agaggaacag gatctgaacg cggccctgaa acgttatttc 660 ccggacggta tcgacattta cttcgaaaac gttggcggta agatgctgga agcagttctg 720 agcaacatgc gtctgaatgg ccgcatctct gcatgcggca tgatttctca gtataatctg 780 gaacagccgg aaggcgtgtg caacctcttt ctcctggtgg gtaaacgtct gcgtatgcaa 840 ggcttcattg tatctgacta ttaccacctg tacccgaagt atatggaaat ggttatgccg 900 ctgatcaaac agggtaccat cagctatatt gaagacatcg tggagggcct ggaaagcgca 960 cctgcggctc tcgtaggcct gttctccggt cgtaatgtgg gtaaacaggt ggtcgtagtt 1020 gctcgcgaat aa 1032 Sequence Number (ID): 91 atggcggaag ttgtggaacg ttccccggag gtagttatcg tccgtaataa acaggtaatt 60 ttcaaggatt atgtgaatgg ctaccctaag gaaacggaca tggttgtgac ttccgacgct 120 accatccgtc tgaaactgcc ggaaaacgaa tccggcctca tcctgactaa aaatctgtac 180 ctgtcctgcg atccttacat gcgtggccgt atgtccaaga ccagcgaggg tagctacgtt 240 ccatccttta cgccgggctc cctgattagc ggttatggcg ttgcgaaagt gctggacagc 300 Firmenich SA 91 acccacccag agtacaagaa atttccggca tcattagctg ggaggaatac 360 tccctgatca aaaacccgga actgttcatc aaaatccaac acaccgacgt gccgctgtct 420 tattacaccg gtattctggg tatggctggt gtgactgctt atgctggttt ctacgaaatc 480 tgctccccga agaaaggtga caccgtgttc gtgagctccg cgtccggcgc agttggtcag 540 ctcgtcggcc agttcgctaa actgcacggt tgttatgtcg tgggttctgc tggttccaaa 600 gaaaaagttg atctcctgaa aaacaaattt ggtttcgatg aggcttttaa ctataaagag 660 gaacacgacc tgaacagcac cctgaagcgt tgtttcccag acggcatcga tatctatttc 720 gaaaacgttg gcggtaaaat gctggatgcg gttctgtgta acatgcgcct gcacggtcgt 780 attgcagttt gcggtatgat ctctcagtac aacctgaacg aacaccaagg tattaataac 840 ctgatcttcg tgatcctgaa acgtatccgt atggaaggct tcctcgtgac tgaccattac 900 cacctgtttc cgaaatttct ggagatggtg ctgcctctga tccaggaagg taaaattacg 960 tacgttgaag atactatcga aggtctggaa aatgccccgg cggctctggt tggtctgttc 1020 tctggcaaaa acgttggtaa acaaatcgtc gacctgaccc aggaataa 1068 Sequence Number (ID): 92 atgggtgaga tggtcgagaa caagcaaatt gtgttgaaag attatgtgag tggctatcca 60 aaggagtctg acatggtgac gcaagtcagt aagatgagtt taaatgtccc ccatggttca 120 aacggcattg ttgtcaagaa tctgtacttg agttgcgacc cttacatgcg tccccgcatg 180 acaaagagcg aaggcggata cgttgactcg ttcactccgg gtcagccgat cacgggctac 240 ggtgtggcaa aggttttgga ctcagggacc cctaaattta agaaaggtga tctcgtttgg 300 ggattcaccg gctgggaaga gtattccttg attacaaaga cggacacact tttcaaaatt 360 gaacacaccg acgtgccatt gtcgtactac acagggctct tgggaatgcc tggcatgacc 420 gcatacgcag gcttctacaa ggttgccacc cccaagaagg gcgaatatgt tttcgtatcc 480 gctgcaagcg gggctgtggg acagcttgtg ggccaatttg caaagcttct tggctgctac 540 gtagtcggaa gtgcaggctc gaaagaaaag gtggatttgc tgaagaacaa gtttggtttc 600 gacgaggcat ttaattacaa ggaagaggaa gacttggcag cggctcttaa gcgttatttt 660 ccggacggga tcgacatcta tttcgagaat gtaggcggca agatgctgga cgcagtcctt 720 gttaacatgc gccctcacgg ccgtattgcc gtttgtggta tgatctcgca atacaacctt 780 gaaaagccgg aaggcatcta caatttaact tatgtgatca tgaagcaatt gcgtatcgag 840 ggctttctgg tgttcgatta ctatcacttg tatcctaagc tccttgagct tgtcctgccg 900 tatatcaaag aggggaagat taactatgta gaggatattg cagaggggct cgaatcagcc 960 cccgccgcgt tagttggctt attttcaggc cgcaatgttg ggaagcaggt agttgccgtg 1020 gcacgtgagt aa 1032 Sequence Number (ID): 93 Firmenich SA 92 atggcgagcg gcggcgaaat aacaagcaag ttattttccg tgactacgtt 60 accggattcc caaaggagtc ggatatggaa ctgactacac gctctatcac tctgaagctt 120 cctcaaggta gtaccgggtt actgttgaag aacctctatt tatcttgtga tccctatatg 180 cgtgcccgta tgacgaatca ccaccgtctc agctatgtag actctttcaa gccaggtagc 240 cctattattg gatatggcgt cgcgcgtgta ttggagagtg gcaaccctaa attcaatcca 300 ggggacctcg tttggggctt cactggctgg gaagaataca gcgtgattac cgcgacagag 360 agcttattta agatccacaa tacggacgta ccgttgtctt actataccgg cttattaggc 420 atgcccggaa tgacggcgta tgccgggttt tatgagatct gcagcccgaa gaagggtgag 480 accgtatacg tgtcagctgc gtcgggagcg gtaggccaac ttgtgggtca gttcgcaaag 540 ttgacgggtt gttacgtggt tggcagtgca ggttccaaag agaaggtgga tctgcttaag 600 aataagttcg ggtttgacga ggccttcaat tataaggaag aggccgattt agatgccgcg 660 ttgcgtcgtt acttccccga tggtatcgat atctacttcg aaaacgtcgg cggtaagatg 720 ctcgatgccg tcctgccgaa tatgcgcccc aagggccgca ttgcggtttg cggcatgatt 780 tctcagtata atctggaaca accggaagga gttcgcaatt taatggcgtt gatcgtaaag 840 caagtgcgta tggaaggttt catggtgttc tcttattatc atctctatgg caagtttctc 900 gaaaccgtgc ttccatacat caagcaggga aagattacgt acgttgaaga tgtcgttgac 960 ggtcttgaca acgcaccggc ggcgctgatt ggtctctact caggccgtaa tgttggaaag 1020 caagtggtgg tggtctctcg tgagtga 1047 Sequence Number (ID): 94 atgacggcca ccaacaagca agtgatcctg aaagactacg tttcaggttt ccccacggag 60 agcgactttg attttacaac tacgacagtg gaacttcgtg ttcctgaagg caccaactcc 120 gtcttggtta agaacttata tctgtcgtgc gacccctata tgcgcatccg catgggcaag 180 cctgacccta gcacagcggc acttgcgcaa gcgtataccc cgggccagcc tattcaaggt 240 tacggggtca gccgtatcat cgagtcgggg catccggact acaagaaggg cgacctgctc 300 tggggcatcg tagcatggga agagtatagc gtcatcaccc ctatgacgca cgcccatttc 360 aaaatccagc atactgacgt acctcttagt tattacacgg gtttgttagg catgcctggt 420 atgaccgctt acgcggggtt ctatgaggtg tgcagcccaa aagagggtga gacggtatac 480 gttagcgccg cgtcaggcgc agtcgggcaa cttgtcggcc aattagctaa gatgatgggc 540 tgctatgtag tcgggtctgc gggaagcaag gagaaagttg acctgctgaa gacaaaattc 600 gggttcgacg atgcgttcaa ttataaagag gagtcggatt taacggccgc gttaaagcgc 660 tgtttcccca atggaatcga catttacttt gagaacgttg gtgggaaaat gttagatgct 720 gttctggtta acatgaatat gcatggccgc attgccgtat gtggtatgat ctcacaatat 780 aatcttgaaa atcaggaagg tgttcataat ctgagtaaca ttatctacaa gcgcatccgt 840 Firmenich SA 93 attcaaggat ttgtcgtgag gataagtaca gcaagttcct cgaattcgtt 900 ctgccgcata ttcgtgaagg taaaatcacg tatgtagagg acgtcgcgga tggcttggag 960 aaagcgcctg aggccttggt gggcttattc catgggaaga atgtcggtaa gcaagtggtg 1020 gtagtggccc gcgagtga 1038 Sequence Number (ID): 95 atggcggaag aggtatccaa taagcaggtc attctcaaga attatgtgac tggatatcct 60 aaggaaagcg acatggagat caagaatgta acgattaagt taaaggttcc tgagggtagt 120 aatgacgttg tggttaagaa cctctacctg tcatgcgacc cgtacatgcg ctcacgcatg 180 cgcaagatcg aagggtcata cgttgagagt tttgcaccag gaagccccat caccggttac 240 ggcgtcgcta aggtcctgga gtcaggagat ccgaaattcc agaaaggcga tttagtatgg 300 ggtatgaccg ggtgggaaga atattcgatt attaccccta cccaaaccct ctttaaaatc 360 cacgacaaag atgtgccttt atcatactac accggtattt taggaatgcc tggtatgacc 420 gcttacgctg gtttccacga ggtctgttca ccaaagaagg gcgagaccgt tttcgtttca 480 gcggcgagcg gcgcggtcgg gcaactcgtc ggtcaattcg cgaagatgtt aggatgttat 540 gtcgtcggta gtgcaggcag caaggagaaa gtagatctgc ttaagagcaa atttggtttc 600 gacgaggcgt tcaactacaa ggaagagcag gatttgagtg cggcgttgaa gcgttacttt 660 ccagacggca tcgatatcta cttcgagaat gtcggcggaa agatgctgga cgccgttctt 720 gtgaacatga agttgtatgg tcgcattgca gtatgtggca tgatttcgca atacaattta 780 gagcaaacag aaggcgtcca caatctgttc tgtctcatca cgaaacgtat ccgcatggaa 840 ggcttcctgg tcttcgacta ctatcacttg tatccgaagt acttggagat ggtaattcct 900 caaatcaagg cggggaaggt agtctatgta gaggacgtgg cgcatggctt agagagcgcg 960 ccgacagcac ttgtaggcct tttcagtggc cgtaatatcg gtaagcaagt agtcatggtg 1020 agccgcgagt aa 1032 Sequence Number (ID): 96 atgggtcaac aaaagcaacg taaccgccgt tgggttctcg ctagccgccc tcacggtgcc 60 ccggtaccgg agaattttcg cctggaagag gacgacgtag ccactccggg tgagggtcaa 120 gtactcctgc gcacggttta cctgtcgtta gacccctata tgcgtggtcg tatgagtgat 180 gagcctagtt acagcccgcc ggtcgacatt ggtggtgtga tggttggtgg cactgtcagt 240 cgcgttgtcg aatctaatca tccagattac cagagtggtg actgggtgct tggctacagt 300 ggttggcaag attatgatat ctctagcggt gatgacctcg tcaagctcgg cgaccacccg 360 caaaatccta gttggagcct cggcgttctg ggtatgccag gctttacggc ctatatgggt 420 ctcctggaca tcggccagcc taaagagggt gagaccttag ttgtagctgc ggccaccggc 480 ccggtaggcg ctacggtagg ccaaattggc aaattgaagg gctgccgtgt tgtcggcgta 540 Firmenich SA 94 gcgggcggtg cagagaaatg actgaggtat tagggttcga cgtatgcctc 600 gaccaccatg ctgacgactt tgccgagcag ctcgcgaaag cctgccccaa gggcattgac 660 atttactacg agaatgtggg tggcaaggta ttcgacgccg tcctgcccct cttgaacacc 720 tctgctcgca tccctgtgtg cggcctcgtt agcagctaca acgccacaga gttaccgccc 780 ggtccggatc gtttaccgtt gttaatggcc acggtgctga agaagcgtat ccgtttacag 840 gggtttatca tcgctcaaga ttacggccac cgtatccacg agtttcagcg tgaaatgggt 900 caatgggtaa aggaagacaa gatccattac cgcgaggaga ttacagacgg gctggagaat 960 gcaccacaaa ctttcatcgg tctgttaaag ggcaagaatt tcggaaaggt cgtcattcgc 1020 gtcgctggtg acgattaa 1038 Sequence Number (ID): 97 atggccccgg ttactaacgg ccgtatcatt tttaacagca ttccgaccgg cttcccggtt 60 ccgggcgaaa ccactatcta tgatacgacc gaaaccatcg atctggatac tgctccgctg 120 gatggcggtt tcctcctgaa aaccctggaa ctgtctgttg atccgtacat gcgtggcggt 180 atgcgcgcac cggaaaagaa aagctactcc gccccgttca ctctgggcca gccgctgcgc 240 ggctatggtg taggtgtggt tctgcgttcc gagaacccac aggtaaaggc aggtgaccac 300 ctgtacggct ttttcgagca cacccattat agcatccgta aggacctgac cggcctgcag 360 gcgatcgaaa atgcatataa cctgccttgg agcgtgttca ttggcgtgat cggtatgcca 420 ggtaaaactg cttacatggc gtggaaagaa tatgcgcacc cgaaacaggg tgaaactgtc 480 ttcgttagca ctggtgctgg tccggttggc agctttgtaa tccagctggc aaaagcggat 540 ggtctgaagg tgatcgcgtc tgcgggctct gaggaaaaag ttcagttcat gaaagaagtt 600 ggcgctgacg tagcgttcaa ctacaaaacc actaacactg cagaagttct ggagaaagaa 660 ggcccgatcg acatctattg ggacaacgtc ggcggtgaga ctctggaagc tgcgctgaac 720 gcagctaacg tgaacgctcg cttcattgaa tgcggcatga tttctggcta caactccggc 780 ggtgctccgg tgcgtaacat cttccacgtg attggcaaat ccattaccat gaccggtttt 840 atcgtatctc gtatcgaacc gaagtactct gcagaattct acaaagaagt accggcaaag 900 gtggcgtctg gcgaactgaa atatcgtgaa cacgtttaca acggtctgga gaagctgggc 960 gatgtcattc tggcagtcca gaaaggtgag aacaaagcaa aagcagttgt gcatgttgcc 1020 gatgactaa 1029 Sequence Number (ID): 98 atggcgagcg tgaccaacgg ccgtgtgctc ttcaactcca ttccggaggg tttcccggaa 60 ccgggtaaaa cggtcgttta tgacacttct gaaaacatcg atctggacac tgttccgctg 120 aacggtggct ttctcctgaa gaccctggac ctgtccattg acccgtacat gcgcggtcgt 180 atgcgtgcac ctgaaaagaa aagctactct ccgcctttcc tcctgaacca gccgatcgat 240 Firmenich SA 95 ggctacggtg ttggcgtagt gaactgccgg aagtcaaggc tggcgaccat 300 ctgtatggct ttttcaagca cgttcagtac gacgtacgta ccaacctgga aggcctgtct 360 aaactgccga acgaacacgg tctgtcctgg tctgtgtatg taggtgctgc aggtatgcca 420 ggcaaaactg cgtatatggc gtggaaggaa tatagccagg caaagaaagg tgagactgta 480 ttcgtgtctg ctggtgcggg tcctgtaggt agcctggtaa ttcaatttgc gaaggctgat 540 ggcctgaaag tgatcggttc cgcaggttct gacgaaaagg ttcagttcat gaaagagtgc 600 ggtgcagacg tagcattcaa ctacaaaacc acgaacacca aggaagtcct ggaaaaagag 660 ggccctatcg atatcttttg ggataacgtt ggtggcgaaa ccctggaagc ggccctggag 720 gctgcgaacg ttaacgcgcg ttttattgag tgcggtatga tctctggcta caacagcggt 780 ggcgcgccga tccgtaacct gttccacgta gtgagcaaga gcatctctat gcacggcttc 840 atcgttagcc gtctggagcc gaaatatggt aaagaatttt acgaaaccat cccgcacaag 900 ctggcatctg gtgaactgaa acaccgtgaa cacgtctttg atggtctgga taaagtcggt 960 gaagcgctgc tcgccgttca gaaaggcacc aacaaggcga aagctgttgt gaaagttgct 1020 gatgagtaa 1029 Sequence Number (ID): 99 atgaatccga agtataagcc attgtttgaa ccgtttacct tcaaaagcgg cgtcaccatt 60 aacaatcgta ttgccgtagc gccaatgact cactacgcct cgaatgagga cggcacgatt 120 tcagaggcgg agcttgatta catcatcccg cgcagcaagg agatgggtat ggttatcacg 180 gcgtgtgcca atgtcacccc cgacggcaaa gcgtttcctg gccaacctgc catccacgac 240 gactcgaata tccctggtct taagaagctg gcccaggcca ttcaagcgca aggcgccaag 300 gcggttgttc aaattcatca tggtgggatc gagtgtcctt ctgagttggt tccgcaacaa 360 gacgtggtgg gcccctctga cgtgtttgac aatggcaagc aaattgcccg cgcgttgacc 420 gaggaagagg ttgaaaacat tgtaaaggcc tttggcgagg caacccgccg tgcaattgag 480 gcgggattcg acggcgtgga gatccacggt gcgaacggct acttgatcca gcaattctac 540 tcgccgaaga cgaatcaacg cacagatcgc tggggcggaa gcgatgaaaa gcgcctcgct 600 ttccccttag cgatcgtaga tgaggtaaag aaagccgcat ctgaacacgc caagggcgcg 660 ttccttgtcg gttaccgttt gagccctgag gaaccagaga cacctgggct tacaatgact 720 gagacgtaca cactcgtgga cgccctcggt gacaaggagc tggactatct tcatatctca 780 ttgatggacg ttaattctaa ggcccgccgt ggtgcggatc ccacacgtac tcgtatggac 840 cttctgaacg agcgcgtagg aaataaggta ccgctgattg cggtgggctc aatccacagc 900 gcggacgacg cactggccgt cattgagaat ggcatcccac tggttgcaat gggacgcgag 960 attctggtgg accccaattg gacagtgaag gttaaggaag gtcgtgagaa gcaaatcgag 1020 acagtaatta aaggcacgga caaggaaaag taccatttgc cagagccgct ctggcaagcc 1080 Firmenich SA 96 attgtgaata ctcagggttg aaggactaa 1119 Sequence Number (ID): 100 atgaacccaa aatataaccc actgttcgag gcttttaccc tgccgtctgg tgttaccctg 60 aagaaccgta tcactatggc cccgatgact aacttcgctt cccacgagaa cggcgaagtt 120 tccgacgaag agctggctta ttaccgcgaa cgtagcggcg gtgtcggtgc agtgatcacc 180 gcgtgcgtat acgttacccc ggacggcaaa ggcttcgtca atgaattctc tgcagataag 240 gacgaaatga ttccatctct gcgtcgcctg gccgacacta ttcaccagga aggcgctaag 300 gcaattctgc agatctatca cggtggccgc ctctgccctc cggatcaaat cccagatggc 360 cagccgattt ctgcaagcgc tgttgctgag gaaaaagaag gtgctccagt accgcgtgaa 420 atgacctctg atgacatcca ccgtgtaatc cgtgcgtacg gcgaggctac gcgccgtgcc 480 atcgaggcgg gttacgatgg tgttgagctg cacggcgcga acggttacct ggtgcaacag 540 tttttctccc cgcactctaa catccgtacc gacgaatggg gtggctccct ggaagagcgt 600 ctgactttcc cgctggccgt ggttcacgaa gttaaaaagg ttatcgctga acatgcgaaa 660 cgtccgttca tctttggcta ccgcctgagc ccggaggaag gccacactcc aggcatcacg 720 ctggatgaca ctatggttct ggttgatcgt ctggcagatg agggcctcga ctatctgcat 780 atctctgtaa accacttctt tggcggttcc ttccgtgatc gtagcgacga gcgttcccgt 840 accgttctga ttcacgaaaa agtgggcaac cgtgttccag tgatgggtgt aggtagcctg 900 aataccccgg acgaggcact ggcggcactg gaaaccggcg tgccactggt atctctcggt 960 cgcccgctcc tgatggaacc gcagtgggtt cagaaagtcc agaacggtac tgaggacacc 1020 atccgtacta ccctgagcaa acaggcgcag caagagctgg ttatcccgga ttacctgtgg 1080 ggcgctctga cgactatccc gggctggatg ccggtaactg attaa 1125 Sequence Number (ID): 101 atgaataccg agctgctttt caaacctttc aaggcgggta acttatcgct tcccaatcgc 60 atcgttatgg cccccatgac acgtaatttt agccctcaag gtatcccggg cccggaagtt 120 gcggcctact accgccgtcg tgcagaaaat gcggtaggtc tcattatcac cgagggtacg 180 gcgattaatc atcccgccgc tgtcgagcac acctcaatcc cgaacttcta cggcgagggc 240 cttgagggat gggcaaaggt cgtcgaggaa gtccatgcgg taggcgggaa gattattcct 300 catgaattgt ggcatgtcgg caccgctcgc aagattggcg ccgacaacca gccgaatcct 360 gaagccctgc ctgtaggccc ttcgggtatt agcccggccg gtgaaaaggt ggtggagccc 420 ctcaccgagg ccgaaatcgc ggacattatt agtgcctacg cccaagccgc ggctgatgca 480 caacgtgttg ggttcgatgg gatcgagctg cacggcgcac acggatactt aatcgatcaa 540 ttcttttggg acaagacaaa taagcgtacg gaccaatacg gcgggaattt ggtgcaacgt 600 acccgctttg cagtggaagt tatcgaggcg tgtcgccgcg ccgttggtcc gaattttcca 660 Firmenich SA 97 atcgttcttc gtttctcaca taccattacg aggagaagct cgctcaaact 720 cctcaagagt tggagcaatt cttgaccccc ttggttaagg ctggagtaga catctttcac 780 tgcagctcac gccgcttctg ggaaccggag ttcgagggta gcgatctgaa cctggcggcc 840 tggaccaaga agattaccgg aaagcctgta atcactgttg gaagcattgg ccttgagaag 900 gcctttctca gcgatttaga gaagaacaat aatcgtcaga ccgaccaatc aagctctgta 960 gaagcccgtt tggagcaatt agtcggtcag gtggagcgcg aagaagctga tctggtggcc 1020 gttggacgcg cgcttcttgt tgacccggcg ttcgccgtga aactccgcga ccaacagatc 1080 gaagagatca tcccttacag tgatgaggtt ttaaagacac tcaactaa 1128 Sequence Number (ID): 102 atgaatacca tgcttttcag tccctatact attcgtggtt tgacacttaa gaaccgtatc 60 gtcatgagcc ctatgtgcat gtactcctgc gacacgaagg atggcgccgt acgcacgtgg 120 cacaagattc attacccggc acgcgccgta ggccaagtgg ggctgattat tgtggaagcg 180 actggagtga cccctcaagg acgtatctcc gaacgcgact tgggcatttg gagcgatgac 240 cacattgcgg gacttcgcga gctggtcggt ctggtgaaag agcatggagc ggccatcggc 300 atccagctgg cgcatgcggg acgcaaatcg caagtcccag gggagatcat cgctcctagc 360 gcggtacctt ttgacgacag tagtccgacc cctaaagaga tgactaaggc ggatatcgag 420 gagacggtac aagcgtttca gaatggtgcc cgccgtgcta aagaggccgg cttcgatgtc 480 attgagattc atgcggcgca cggttacctg atcaacgagt tcctgtctcc tctgagcaat 540 cgtcgccaag atgaatatgg cgggtcgccc gagaatcgct atcgttttct tggggaagta 600 attgatgccg tgcgtgaggt gtgggatggc ccattattcg tacgtatcag cgcatcggac 660 tatcatccgg acggtttgac tgctaaagac tacgtaccct acgcaaagcg tatgaaggaa 720 cagggagtag acttagtgga cgtgtccagc ggcgccatcg tcccagcccg tatgaatgtc 780 tacccaggtt atcaagtgcc atttgcggag ctgatccgtc gcgaggccga cattccaacc 840 ggcgcggttg ggttgattac gtctggctgg caagccgaag aaattctgca aaacggtcgc 900 gcggacttag tgtttctggg acgcgagttg ttgcgtaatc cttactggcc ttatgcggca 960 gcccgtgagc tgggagccaa gatctcggcc cccgtccaat atgagcgcgg ctggcgtttc 1020 tga 1023 Sequence Number (ID): 103 atgaccggca aactgttcag cccgatctct gttggcccgc tgtctctgcc aaaccgtatc 60 tttatggctc cgctgacccg tatgcgttct cgtgaacctg gtgacgttcc ggttctgccg 120 ctgatggctg agtactatcg tcagcgtgct aacgcaggcc tgatcattag cgaagcaacc 180 caggttagcc cgcagggtaa aggttacatg ggcactccgg gtatccacag cgctgaacag 240 gttgaagcgt ggcgcgacat tactcgtgca gttcatgacg aaggcggtca cattgctatt 300 Firmenich SA 98 cagctgtggc atgtcggccg cactctctgc agccggatcg ccagctcccg 360 gtgtctgctt ccgccatccc gtatgagaac aaaactacca ttcgtggcga agatagcaaa 420 ccgcaacgtg ttgcttgcga taccccgcgc gctctgcgta ctgatgaaat tccgggtctg 480 atcgaaactt accgtcaagc cacgatcaac gcgcgcgaag caggtttcga cctggttgaa 540 gttcacgcag cgcacggcta cctcctgcac caattccagt ccgccgtgtc taaccaccgt 600 gatgacgctt atggcggttg cctggaaaac cgcgcgcgtc tgactctgga ggttgtggac 660 gcctgtattg cggcatggga cgcagcgcat gtcggtatcc gtatctcccc gctgggtacc 720 ttcaacggcc tggatgactc cgctggtctg gaaatgggtc tgtatctggc cgaacagctg 780 gcgaaacgta atatcgccta cctccacctg tccgaaccgg actgggctgg cggtccggct 840 cactccgatg aattccgcca ggctctccgt gatcgtttcc ctggtgtcat tatcggcgcg 900 ggtaactata ccgttgaaaa agccgaagca ctgctcgcaa agggctatat cgatgccgct 960 gcattcggtc gtccatacat ctccaacccg gatctggcgg aacgtttccg caccggtgca 1020 gcgctggcta tgctgaaccc ggccaccctg tacggtggcg gtgaggaagg ttataccgac 1080 tacccggccc tggcctaa 1098 Sequence Number (ID): 104 atgtccggta aactgttcac cccggttacc atcggtggct tcactctgcc gaaccgcgtt 60 ctgatggcgc cgctgactcg tatgcgctct tcccagccgg gtgacgtgcc gaacgaactg 120 atgcaagcgt actatgtcca gcgtgcatcc gcaggcatga ttatcgcaga agctactcag 180 atttccccac agggtaaggg ttatatggat acccctggca tctactctgc agaacaggtt 240 gcgggttgga agaaaattac ccaagcagtt catgaagcga acggccacat ctgcctgcag 300 ctgtggcatg ttggtcgtgt gtctcatcac tccctccagc cggatcaaca gctgcctgtg 360 tccgctagcg cgatcccata cgaaaaccgc actaccgtgc gtggtgaaga cggtaaagtg 420 aaacgtgttg cgtgcgatac cccgcgcgcc ctggaactga ctgaaatccc gggtctgatc 480 gaagattacc gccgtgccac tgtaaacgcg cgcgaagcag gcttcgatat ggtggaagtt 540 cacgcggctc acggttacct cctgcatcag ttccagtccg caacctccaa ccagcgcaac 600 gacgcttatg gtggcagcct ggagaaccgc gcgcgtctga ccctggaagt tctggacgct 660 gtcatcggtg cttgggacgc tgcacacgtg ggtatccgta tctccccgct gggtattttc 720 aacggcctgg acgatcgtga cggtctggac atgggtctgt acctggctga acagttcgct 780 ctgcgtggta ttggttacct gcatctgtct gaaccggatt gggccggtgg ccctgttctg 840 aatgaagagt tccgcgtagc actccgtgca cgtttcccgg gtattatcat tgcagccggt 900 aactacagcg tagaaaaggc agaaggcctc ctggaaaaag gtctgatcga tgccgcggcc 960 ttcggtcgcc cgttcatcgc aaacccggac ctgccgcagc gtctgcgtaa aggcgcggaa 1020 ctgaatgcag ttaacgcagc gaccctgtat ggtggcggtg cggaaggcta caccgactac 1080 Firmenich SA 99 ccggcactgg cctaa 1095 Sequence Number (ID): 105 atgtcgggta agctgtttac acccttttcc tcgggctctt ttacattccc taaccgtgta 60 atcatggcac ccttgacccg tatgcgtgcg tcgcagccgg gtgacattcc caacgagctt 120 atgcaaactt actatgtaca acgcgcgtct gccggattaa tcatcgcaga ggcgactcag 180 atctctcctc aggggaaggg ctacatggac acaccgggta tctatagcgc cgagcaagtt 240 caaggctggc gcaagattac gcaagcagta catgaggccg gtggtcacat tgctctgcaa 300 ctgtggcatg tcggtcgcgt atctcaccac tccttgcaac ctgatcaaca gcttcccgta 360 tcagcgtcag ccattcccta ccaaaatcgc acaactgttc gcggtgagga cgggaaacca 420 acacgcgtgg attgtgatac cccgcgtgcg ctggagttaa gcgagattcc gggcgttatt 480 gaagactatc gccgtgcaac ggttaatagt cgcgaggccg gttttgacat ggttgaagtg 540 catgccgccc acggttattt acttcatcag tttcaatcgg ccgaatcaaa caagcgcgag 600 gatgcgtacg gcgggagttt agagaaccgc gcgcgtttaa ccctggaagc attggacgcc 660 gttatcggag cgtgggacgc gaagcacgtc gggattcgca tcagccctct gggtactttc 720 aacggtctgg atgacaaaga tggcttggaa atggcactct acttgacgcg cgagttcacg 780 aagcgtggaa ttgcgtacct tcacctctct gagccggact gggcgggcgg gccggcccac 840 ggagatgaat ttcgccaggc attgcgtgac gcgtttcctg gtaccattat cggggcggga 900 aattacactg tggaaaagtc tgagatgctt cttgccaagg gcttcatcga cgctgcggcg 960 tttggacgcc cgttcatcgc gaacccagac cttccggtac gtctgcaaaa gggcgcggag 1020 ttaaacaatg tagtggccgc tacactctac ggggggggtg ccgagggcta cacagactat 1080 ccagcgctgg cctga 1095 Sequence Number (ID): 106 atgaaactgc tccagccgct tcagattggt ccgttaacct tgcctaaccg tgtgtttatg 60 gcacccctca ctcgtcttcg ctcactggag ccgggcgatg tcccgaccac tctgatgggt gaatattatc gccagcgtgc cagcgccggc cttatcatca ccgaagcgac ccaaattagc tttcaagcaa aaggttacag tggtagcccc gggatccact ccgcagaaca aattgctgcg tggaaacaca tcaatgaagg cattcatgct gacggcggtc acagcgcggt tcaggtgtgg cacacgggac gcgtcagcca cacttcactg cagccaggcg gagaagcacc tgttgcaccc tcggcactgc cagctggggc gcgtacgact cttcgcgacg aacagggtga tcttattcgt gtggaaacta gcgccccgcg cgccttgtcg gaagctgaga tcgcgggtat tgtggcggat tttggactcg cggcgattaa tgcgcgtgaa gcgggatttg atttcattga actgcatgct gcacatggct acttactgca ccaatttctt actccttccg caaatcagcg cgaagatcgt tacggcggct ccgtggagaa ccgcgcccgt attgtcctgg aagccgtaga tgcggcggta Firmenich SA 100 gccaactggt ctgccgaacg cgcgtctttc ccttaggtgg gttcaacggc 720 gtagacaatg gggaagatca ggaagcggcc ggcctgtact taattcgtga actggccaaa 780 cgtaacttag cgtacctgca tctgtctgaa ccagactggg cgggcggtaa accgcttcgt 840 gatgagtttc gccaagccat tcgcgcagca tatccgggag taattatcgc cgccggggcg 900 tacaccgccg agaaaggcga ggaccttatc ggtcgcggcc tcatcgatgc cgtagccttt 960 ggtcgttcgt atatcgcaaa tccggacttg gtggaacgtt tacgtcttca agcgccgtta 1020 aacgaacacc gcgcgcagtt tgattacgcg aatggcccgg aaggatatac cgattatccc 1080 ttccttaaac aggcctaa 1098 Sequence Number (ID): 107 atgtctagcg aaaaactgta ctctccgctc aaagtcggtg caatcaccgc cgcgaaccgt 60 atcttcatgg ctccgctgac ccgtctgcgc agcatcgaac cgggcgatat cccgaccccg 120 ctgatggcag aatattaccg ccagcgtgct tctgctggcc tgatcatttc cgaggcaact 180 cagatctccg ctcaggcaaa aggctacgcg ggcgcgccgg gcatccactc cccggaacaa 240 atcgcagcgt ggaagaaaat taccgctggt gttcacgcag aaaacggtca catggcagtc 300 cagctgtggc atactggccg catctcccac gcgtccctgc agccgggtgg ccaagcccct 360 gttgctccgt ctgcgctgag cgccggtacc cgtactagcc tgcgtgacga aaacggccag 420 gctatccgcg tcgaaacctc tatgccgcgc gccctggaac tggaggaaat cccaggcatc 480 gttaacgact tccgccaggc gatcgcgaac gcgcgtgaag ctggtttcga tctggttgaa 540 ctgcacagcg cgcacggcta cctcctgcac cagttcctgt ctccgtctag caaccaccgc 600 actgaccagt atggcggtag cgtggaaaac cgtgctcgcc tcgttctgga agtggttgat 660 gcgggcatcg aggaatgggg cgccgatcgt attggtatcc gtgtcagccc gattggcacc 720 tttcagaaca ccgataacgg cccgaacgag gaagcggacg ctctgtacct gatcgagcag 780 ctgggtaaac gtggtatcgc gtatctgcac atgtctgagc ctgactgggc aggcggtgag 840 ccgtacaccg atgcattccg cgagaaagtt cgcgctcgtt ttcacggccc aatcattggt 900 gcgggcgcgt acaccgtcga gaaggcggaa actctgattg gcaagggcct gatcgatgcg 960 gttgcattcg gccgcgactg gatcgcgaac ccggatctgg tagcgcgcct gcagcgtaag 1020 gctgaactga acccgcagcg tgctgaatcc ttctatggtg gcggtgcgga gggctacacc 1080 gattacccta ccctgtaa 1098 Sequence Number (ID): 108 atgagcgctg aaaagctgtt cacccctctc aaggttggtg ctgtaaccgc gccgaatcgt 60 gtcttcatgg cgccactgac tcgtctgcgt agcatcgaac ctggcgacat cccgaccccg 120 ctgatgggtg agtattaccg tcagcgcgcc tccgcgggcc tgattatctc cgaagcgacc 180 caaattagcg cgcaagcgaa aggctacgcg ggcgcgcctg gtctgcactc cccagaacag 240 Firmenich SA 101 atcgccgctt ggaagaaaat gtgcatgccg aagatggtcg tatcgcggtt 300 caactgtggc acaccggtcg catcagccat tcctctattc agccgggcgg tcaggctccg 360 gtttctgcat ctgctctgaa cgcgaacact cgtacctctc tgcgtgacga aaatggtaat 420 gctattcgtg ttgacaccac gactccgcgt gctctggaac tggatgaaat tccgggcatc 480 gtaaacgact ttcgtcaagc ggttgcaaac gcacgtgaag caggcttcga tctcgtcgaa 540 ctgcatagcg ctcatggtta tctcctgcac cagttcctgt ctccgagctc caaccagcgc 600 accgaccagt acggcggtag cgttgaaaac cgtgcgcgtc tggtactgga agttgtagat 660 gccgtttgca acgaatggtc cgctgaccgt atcggtatcc gtgttagccc tatcggcacc 720 tttcagaacg tggataacgg tccgaacgag gaagcggacg ctctgtacct gatcgaggaa 780 ctggctaaac gcggtattgc atacctccac atgtctgaaa ctgatctggc aggcggtaag 840 ccgtattctg aggctttccg tcagaaagtt cgcgagcgct tccacggtgt aattatcggc 900 gctggtgctt acaccgcaga gaaagcagaa gatctgatcg gcaagggtct gattgatgct 960 gtggcctttg gccgtgatta catcgccaac ccggacctgg tggcacgtct gcagaagaaa 1020 gctgaactga acccgcagcg cccggagagc ttctatggtg gcggtgcaga aggttatacc 1080 gattacccgt ccctgtaa 1098 Sequence Number (ID): 109 atgaaaaccg ctaagttatt ttctcccctc aaggtcggtg cgctgaccct gcccaatcgc 60 gtgtttatgg cccccttgac gcgtttgcgc tctattgagc caggtgatat cccgacccct 120 ttaatggcgg agtactatcg tcaacgcgca agcgccggcc tcatcatcac tgaggctacc 180 cagatcagct ttcaggccaa ggggtacgca ggcgcaccgg ggcttcacac acaagaacaa 240 ttaaatgcgt ggaagaagat tacgcaagcg gttcacgagg agggaggtca tattgcggtc 300 caattatggc acgttggccg cattagtcac tcaagcctgc aacccggtca gcaggcaccc 360 gtggccccta gcgctattgc tgcagacacc cgtaccaccg ttcgtgacga aaacggcgca 420 tgggtacgtg tgccatgctc tacaccgcgc gcattagaga cggaagagat cccgggcatc 480 atcaacgatt tccgtcaggc gactgctaat gctcgtgagg ccggattcga ctatatcgaa 540 ctccacgccg cgcacggtta tctcctgcac caatttatgt cacccgcctc aaaccagcgt 600 actgaccaat atggcggtag tattgagaac cgcactcgct taactttaga ggttgtcgat 660 gcgacggccg cccagtggtc agcagagcgc attggtatcc gtatcagccc acttggaccc 720 ttcaacggtc tggataacgg tgaagaccaa gaggaagctg ccctgtacct gatcgacgag 780 ctgaataagc gccatattgc atacttacat atctctgagc ccgactgggc gggtggcaag 840 ccttattcag aggcgttccg cgatgctgtg cgcgcgcgct tcaagggcgt gattatcggg 900 gcgggagctt ataccgcaga gaaagccgaa gaattaattg agaaaggctt tatcgacgcc 960 gtagcatttg gacgcagcta cattagcaat cctgacctgg tggcacgctt gcagcaacac 1020 Firmenich SA 102 gcgcccctga atgaacccga ttttatggtg gcggggctaa gggttacacc 1080 gactatccaa ccctttga 1098 Sequence Number (ID): 110 atgaaaaccg ccaaactgtt ctctccgctg aaagtgggtg cgttcaccct cccgaaccgc 60 gttttcatgg cacctctgac ccgtctgcgt tctattgaac caggcgatat cccgaccccg 120 ctgatggcag aatattacgc gcagcgtgcc tctgcaggcc tgatcattac tgaagccacc 180 caagttagct tccaggcgaa aggttacgcg ggcgcgccgg gcctgcacac ccaggaacag 240 ctggaaggtt ggaagaaaat cacccaggca gttcacgaga aacaaggcca tattgctgtt 300 cagctctggc atgtgggtcg catttctcat cactctctgc agcctaacca gcaagcacca 360 gttgctccga gcgccatcgc ggctgatacc cgcaccacga tccgcgatga aaatggtgat 420 tgggtccgcg tcccgtgtag cactccgcgc gcactggaac tgcaggaaat cccggctatc 480 gtcgatgact tccgcaacgc caccgcaaac gcacgcgaag caggtttcga cttcattgaa 540 atccatgcag cgcatggtta cctcctgcat cagttcatgt ctccggcgtc taaccaacgc 600 actgacgcat acggcggttc tattgaaaac cgcacccgtc tgactctgga agttgtcgac 660 gcaactgccg ctgaatgggg cgcggagcac atcggtatcc gtatctctcc gctgggcccg 720 tttaacggcc tggataacgg cgaagaccag gaggatgcag ctctgtacct gattgatgaa 780 ctgaataaac gcaaaattgc ctacctgcac atctctgaac cggactgggc tggtggcaaa 840 ccgtataccg acgctttccg tgatgcggtg cgtgcacgtt tcaatggcat tatcgtgggt 900 gctggtgcct acaccgccga aaaagccgaa actctgatcg aaaaaggttt catcgacgct 960 gtcgcttttg gtcgtagcta catcgcgaac ccggacctgg tcgaacgtct gcagcaacag 1020 gctccgctga acaccccgga cggcgatacc ttctacggcg gtggcgcgaa aggttacacc 1080 gattatccga ccctgagcta a 1101 Sequence Number (ID): 111 atgacttctc tcttcgaccc tctgaagatt ggcgacatcc agctggcgaa ccgtatcgtc 60 atggcgccgc tcactcgtaa tcgttctcct ggcgctgtac caaacaccct gaatgcagct 120 tattacgagc agcgtgcctc tgcaggcctc ctgatcaccg aagcaacggc aatctctcac 180 cagggccagg gctacgccga cgttccgggt ctgtataaac cagaggcgct ggagggttgg 240 aaacaggtga ctgacgctgt gcataaagcg ggtggcaaaa tcgtggtcca aatgtggcac 300 gttggtcgca tctctcacga caccctgcag ccgaacggtg gcaagccggt tgccccgtcc 360 gctatccgcg ctaaaagcaa aacgtacctg attaatgctg atggtactgg tagctttgca 420 gaaacctctg agcctcgtgc cctggaaaaa gacgaactgc cgggcattat cgaagattac 480 cgccgtgcgg cacgcgcagc cgtcgacgcg ggtttcgatg gtgttgaaat tcacgccgca 540 aacggttacc tcctggatca gtttctgcgc tccggttcta acgaacgtac tgatgaatac 600 Firmenich SA 103 ggcggttcca ttgaaaaccg ctgttccaag ttgtggatgt tatcaccaaa 660 gaaattggcg cgggtcgcac cgcaattcgt atttcccctg tgaccccagc gaacgacagc 720 tctgatccga acccacaacc gctcttcacc tacgttgtgg aaggtctggc aaaatatgat 780 ctggcttaca tccacattat cgaaggtgcg acgggtggcc cgcgtgacca ccaacagggt 840 gacgccccgt tcgactacgc ggccctgcgc gccgcttacc aggcagccgg cggtaaagca 900 gcttggatgg ttaataacgg ctacaaccgc gagctggcga ttgacgcggt agaggaaggc 960 aaagcagacc tggtggcatt cggcaaactg ttcatcgcga acccggatct ggtagagcgt 1020 ctgaaaaacg acaccgtgct gaacccaccg gaccaggcga ccttctacgg cggtggcgcg 1080 aaaggctaca ccgattatcc ggcactggaa aacgtggctt aa 1122 Sequence Number (ID): 112 atgaccaaac tgttcgaacc ggcacaggcg ggtgatatcg cactggcgaa ccgcatcgtc 60 atggctcctc tgacccgtaa ccgttctcct ggtgcgatcc ctaacaatct gaacgcggca 120 tattacgagc aacgtgcgac cgctggtctg atcgtaaccg aaggcacccc ggttagccag 180 caaggccagg gttacgcaga tgtaccgggc ctgtataaac aggaagctat cgacggttgg 240 aaagcagtaa ccgatggcgt ccataaggct ggcggtaaaa tcgtagcaca gatctggcac 300 gtgggccgta tctcccacac ctctctgcag cctcacggtg gccaaccggt ggccccatct 360 cctattaaag cgaattccaa aacttatatt atcaacgacg atggcaccgg ctccttcgcc 420 gaaacttctg aaccgcgcga aatcagcctg caagaaattc cggtaatcct ggaggactac 480 cgtactggcg cgcgtgcggc tattgatgcg ggttttgacg gcgttgaaat ccacgctgcc 540 aacggttacc tgattgatca gtttctgaaa tctggcacca atcaacgtac ggacgcgtac 600 ggtggctcca tcgagaaccg tgcgcgcttt ctcctggaag tagtcgacac cgtgactaaa 660 gaaatcggtg cgggccgtac tggtatccgc ctctccccgg tgaccccggc taatgacatc 720 ttcgaggcgg acccgcagcc actgttcgaa tatgtggctc gtgaactggg cagccgtggc 780 ctggcgttca ttcacgttat cgaaggcgct accggtggcc cgcgcgattt caaacagggt 840 gacaaaccgt tcgactatga cgccctcaaa gccgcgtata ctaatgccgg cggtaaaggt 900 ctgtggatcg cgaataacgg ttatgatcgt gaatccgcga tcgctgcgac cgaatctggc 960 aaagttgatg ccgttgcgtt tggcaaggcc ttcatctcta acccggacct ggtgcagcgt 1020 ctgaaagaaa acgctgcgct gaatgaaccg aaccaacaga ctttctatgg cggtggcgcg 1080 gaaggctaca ccgactaccc ggcgctggca taa 1113 Sequence Number (ID): 113 atgtctgatc tgttcgagcc gactaaggcc ggcgacatcg ccctggcgaa ccgtattgct 60 atggcgccgc tgactcgcaa ccgttccccg ggtgaagcgc ctaacgatct gaacgttact 120 tattaccaac agcgcgcgac tgccggcctg atcattactg agggcacccc tatcacccac 180 Firmenich SA 104 cagggtcaag gctacgctca ctgtacaaac cggaagcact ggaaggctgg 240 aagaaagtga cggatgctgt tcacaaagct ggcggtaaaa ttgttaccca gatttggcac 300 gttggtcgtg ttagccacac ctctctgcag ccaggtgaag gcaaacctgt agcaccgagc 360 gcaatcaccg caaaatctaa aacctatatt atcaaccctg atggcagcgg tgccttcgca 420 gatacttctg aaccgcgtgc tctgtccctg gaggaaatcc cgggcatcct ggaagattac 480 cgcgttgccg cgcgcgctgc ggtcgacgcc ggcttcgacg gtgttgaaat ccacgctgcg 540 aacggttacc tcctggatca gttcctgcgt tccggctcca accagcgcac cgacgcgtac 600 ggtggctcta ttgaaaatcg tacccgtctg actctggaag ttgcagctgt tgtcgcgaaa 660 gaaatcggtg gcggtcgtac tggcattcgt atctctccgg taaccccggc taacgacgta 720 ttcgatccgg aacctcagcc gctcttcaat catctggttt ccaaactggc tggcctggat 780 ctggcattca tccatgtaat cgaaggtgcc accggtggcc cgcgtgactt caaacagggt 840 gataaaccat tcgattggga cgaactgcgt aaaacttatc gtgacgccgg tggcaagggt 900 gcatggatgg ttaataacgg ttacgacaag gcttctgcga ccgaagctgt ggcgtctggt 960 cgcgcggaca ttgtgacttt tggcaagctg ttcattgcta acccggacct ggtacgtcgc 1020 ttcaaggaag atgccccgct gaacgaaccg aacaaagcta ctttttacgg cggtggcgct 1080 gaaggttata ccgactaccc tttcctgccg taa 1113 Sequence Number (ID): 114 atgcctaccc tgtttgatcc gctgaccctc ggtgatctgc agagcccgaa ccgtgtgctc 60 atggccccgc tgacgcgtgg ccgtgcgacc cgcgagcatg tacctaccga actgatgatc 120 gaatactata ctcagcgtgc gtccgcgggt ctgattatca ccgaagccac tggcatcact 180 caggaaggtc tgggctggcc gtacgcaccg ggtatctggt ccgacgaaca ggtcgaagcg 240 tggaaaccgg tcacccaggc ggtacatgag gcaggcggtc gtattatcct ccaactgtgg 300 cacatgggcc gtaccgtgca cagctccttc ctgggcggtg ctaaaccggt atcttcctct 360 gccacccgtg ctccgggcca ggcacatacc tacgaaggta aacaggacta cgacgaggca 420 cgtcctctca gcgctgatga aatcccgcgc ctgctcaatg actacgagca cgcggctaaa 480 aacgctatgg ctgcgggttt cgacggcgtt cagattcacg cggccaacgg ctatctgatc 540 gaccagttcc tgcgcgataa ctctaacgtt cgtggcgacg cttacggtgg ctccattgaa 600 aaccgcatcc gcctcctggt agaagtgact cgccgtgtag cggaaacggt gggtgctgaa 660 aaaactggtg tgcgtctgtc tccaaacggt gattcccagg gcgtgaacga ctctaatccg 720 gagccgctgt tctctgccgc agcgaaagca ctggatgaga ttggcatcgc gcatctggaa 780 ctgcgcgaac caggttacga gggtacgttc ggcaaagcag accgcccacc ggtacacccg 840 gtaatccgtc aggctttcag ccgtacgctg attctgaact ccgactacac cctggaaacc 900 gctcaagcgg cactggctac tggtgaagcg gacgccatca cctttggccg tccgttcctg 960 Firmenich SA 105 gcgaacccgg atctgccgca gaacgtctgc ctctgaacaa agatgttatg 1020 gaaacctggt actctcaggg cccggaaggc tatgtggact acccaaccgc cgaccagaaa 1080 taa 1083 Sequence Number (ID): 115 atgcctaccc tgtttgatcc gatccgtctg ggtgcggtta ccgctaaaaa ccgtatcctc 60 atggcgccgc tgacccgtgg tcgcgcgacc cgtgaccatg ttccaaccga catcatgatc 120 aaatattacg cccagcgtgc atctgcaggt ctgattatct ctgaagccac cggcattagc 180 caagaaggtc tgggttggcc ttacgcaccg ggcatctgga acgaagccca gacccaggcg 240 tggatcccga tcacgcaggc ggtgcacgac gctggcggtc tgattttcgt gcagctgtgg 300 cacatgggcc gcctcgtacc gtcttccgtt tctggcatgc agccagtgag cgccagcgcg 360 actaaagccc cggatctggc tcatacttac gaaggtaaga aacctttcga cgtcgctcgt 420 ccgctggaga tcgcggaaat cccgcgcctc ctggatgact acgagcgtgc gacgcgtaac 480 gcgctgtccg caggcttcga cggcgtccag atccatgctg ccaacggcta tctgattgat 540 gaatttctgc gcgacggcac gaacctgcgc aaagatgcat acggtggcac tccggaacac 600 cgcatccgcc tcctgcgtga agtgactgaa cgtgtaatct ccgttatcgg tgcagatcgc 660 acttccgtgc gcctgtctcc aaacggtgaa attcaaggcg catctgatag ccaccctgaa 720 aacattttcc tgccggcggc ccgcatgctg tctgatctgg gcatcgcttt tctgggtctg 780 cgtgaaggta ccccggaagg cacttttggc cgtaccgatc agccaaagct gtccccgaaa 840 atccgtgagg ttttcaaccc accgctgatc ctcaaccaag actataacct ggaaaccgcg 900 caggaagctc tggacagcgg tgtcgccgat gcaatctctt tcggccgcct cttcatcagc 960 aacccggacc tgccgcgtcg cttctttgaa ggctccccgc tgatcaaaga taacatcgca 1020 acctggtata ctcagggcgc ggaaggttac actgattacc cgctgatcgg taacgagatt 1080 ccggcgtaa 1089 Sequence Number (ID): 116 atgccttcgt tgtttgaccc tatccgtttt ggcgccttca cagccaagaa ccgcatctgg 60 atggcgccct tgactcgcgg tcgtgccacc cgcgatcatg tacccaccga aatcatggcg 120 gaatattatg cgcagcgcgc cagcgcgggc ctcatcatca gtgaggcaac tggcatctct 180 caggaagggt tgggttggcc ttatgcccca ggaatctggt ctgatgccca agttgaagct 240 tggcttccaa tcacccaggc ggtacacgat gccggcggtc tgatctttgc gcaattatgg 300 cacatgggcc gtatggtacc tagcaacgtc agtggtatgc agcctgttgc accgagcgca 360 tcgcaggcgc cgggcctggg ccatacgtac gatggcaaga aaccatacga tgtcgcgcgc 420 gcactccgct tagatgaaat cccgcgtctg cttgatgatt atgaaaaggc cgcccgtcat 480 gcgcttaaag cgggcttcga tggtgtacaa attcatgcgg ctaacggcta ccttattgat 540 Firmenich SA 106 gaattcattc gcgattcgac catgacgaat atggtggagc ggtcgaaaac 600 cgcatccgcc tgctgaaaga tgtcaccgaa cgtgttatcg caaccatcgg taaggaacgc 660 actgcggtcc gtctgtcgcc taacggagaa attcagggca ctgttgatag ccatccggaa 720 caggtgttta ttccggcagc gaaaatgttg agcgatctgg acatcgcatt cttaggaatg 780 cgcgagggcg ctgtagacgg tactttcggt aagaccgatc agccaaaatt gtctccggag 840 attcgcaaag tgtttaagcc ccctctcgtg ctgaatcagg actatacatt cgagaccgca 900 caggcggcgc tggattccgg cgttgccgac gcgatttcgt tcggccgtcc ttttatcggc 960 aacccggatt tgccacgccg tttcttcgaa aaggccccac ttactaaaga tgttattgaa 1020 acctggtaca cacaaacccc gaaaggatat acggattacc ctctgttagg cgactga 1077 Sequence Number (ID): 117 atgaccagcc tgtttgagcc gatcgaactg ggttccatct acgcaaaaaa ccgtatcctg 60 atggcaccac tgacccgtgg ccgttctact cgcgaccacg tgccgactcc tattatggcg 120 gaatattacg ctcagcgtgc tggtgctggc ctgattatct ccgaagctac cggcatcagc 180 cgtgaaggcc tgggctggcc gtatgctcca ggtctgtggt cccaggagca ggttgaagcc 240 tggaagccga tcaccgcggc agtacacgcg aaaggcggta aaatcgttgc acagctgtgg 300 cacatgggcc gtatggttca ttctagcgta accggtcaac agccggtatc ctgctctgcg 360 accaaagcgc cggaagcgct gcacacctat gacggcaaac aggcaccgga agtggctcgt 420 ccgctcacga aagaagatat cgcccgcatc ctgaacgatt acgaaaacgc cgcacgtaac 480 gccctgcagg cgggttttga cggcgtacag attcacgctg ccaatggtta cctgattgac 540 gaattcctgc gcgacggtac caatcaccgt tctgacgagt acggcggttc tccggagaac 600 cgcattcgct tcctgcgcga agtgaccgaa cgtgttatcg cgaccatcgg tgctcataaa 660 acgtccgttc gtctgtctcc gaacggtgac actcaaggct gcatcgactc tcatccggaa 720 caggtgttcg ttccggcatc taaactcctg aacgacctgg acattgcatt tctggaactg 780 cgtgaaccgg gtccgaacgg cacctttggc aaaaccgatc agccaaagct gcacggccca 840 attcgtgaag tgttccgtaa accgctggtg ctgaaccagg actacactcg cgaagaggca 900 atcgaaactg tcgcaaccgg cgtggccgac gctattagct ttggccgccc gttcctggcc 960 aacccggatc tggtgcgtcg cctggaagat aacctgccgc agaacaaaga cgatattcgt 1020 acctggtaca gccagggtgc cgaaggttac accgattatc cactggctcg ttaa 1074 Sequence Number (ID): 118 atgaccactc tgttcgatcc gatcaaactg ggcgcgattg cagccccaaa ccgtattatc 60 atggctccgc tgactcgcgg tcgctcttcc cgtggtcacg tgccgagcgc actgatggct 120 gaatattacg cccagcgcgc ctccgctggc ctgattatca cggaggccac cggtatcagc 180 caggaaggtc tgggctggcc gtacgcgccg ggcatctggt ctgatgaaca ggttgaagca 240 Firmenich SA 107 tggaagccga ttgttcgtgc aaaggtggcc gtattgtgat gcaactgtgg 300 cacatgggcc gtatggtgca ctctaacgtg accggcctgc agccggtttc tgcctctcca 360 acgactgctc cgggtgaggc gcatacttat gacggtaaga aaccatacga acaggcgcgt 420 gctctggaca tctctgaaat cccgcgcctc ctggcggact acgagaacgc cactcgtaac 480 gctctggctg caggcttcga cggtgttcaa atccacgcgg caaacggcta tctcatcgat 540 gaattcctgc gtgatagcac caacaaacgt actgatgctt acggcggtga accagaaaac 600 cgtatccgcc tcctgcgcga agtcaccgaa cgtgttatca gcgtggccgg tgcagatcgc 660 accgcagtcc gtctgtcccc gaacggtgag actcagggta ctattgattc taacccgatc 720 tctgtattcg taccggccgc aaaaatgctg tacgacctgg gtctggcctg gctggaactg 780 cgtgagccgg gccctaacgg cacgttcggc cgcactgatc agccgaaact gagcccgcag 840 attcgtcagg ttttcaaagc accgctggtg ctgaactccg actacactct ggaagaggcg 900 gaaaccgctg tgctggagga tcgtgcagac gctatctcct ttggtcgtaa attcctcgct 960 aacccggacc tgccgcatcg ttttaagtct ggcctgccgc tgaaccgtga cgaaatgaag 1020 acttggtact ctcagggtcc gcagggctac gtggactacc cagcggcaag ctaa 1074 Sequence Number (ID): 119 atgcctacat tatttgaccc aatcgatttt ggccccattc atgcgaagaa ccgcatcgta 60 atgtctcccc tgacccgtgg acgcgctgat aaagaggccg tccctactcc tatcatggcc 120 gaatattatg cccagcgcgc aagcgcaggc ctcatcatca ctgaagcaac gggaatcagt 180 cgcgagggcc tcggttggcc atttgcaccg ggcatctggt cagatgccca ggttgaggcg 240 tggaaaccga ttgtcgcagg ggtacatgcc aaaggtggca agatcgtatg ccagctgtgg 300 cacatgggac gcatggtaca ttctagcgtt accggcacgc agcctgtgtc gtcaagcgcg 360 acaaccgctc cgggtgaagt gcatacctat gaaggtaaga agccatttga gcaggcgcgt 420 gcaatcgatg cggccgatat ctcccgtatt ctgaacgatt acgaaaatgc ggcacgcaac 480 gccattcgtg ctgggtttga tggtgtgcag attcatgcgg cgaacggcta tctgatcgac 540 gaattccttc gtaacggaac caatcaccgc actgacgaat atggcggagt tcccgaaaat 600 cgtatccgtt tcctcaaaga ggtcaccgag cgtgtcatcg cagcaatcgg tgccgatcgt 660 actggagtgc gtctttctcc taatggcgat acacaggggt gcatcgatag cgcgcccgag 720 actgtgtttg ttccggccgc gaaactgctt caggatctcg gtgttgcgtg gttagaactt 780 cgtgaaccgg gtccaaacgg gacgttcgga aagacggatc aacccaagtt atcaccccag 840 attcgcaaag tctttctgcg ccctctcgtc ctgaatcaag attatacttt tgaagctgcg 900 cagaccgcct tggctgaagg taaagcggat gccattgcct tcggccgtaa gtttatcagt 960 aatccggatt tgccagaacg cttcgctcgt ggtatcgctt tgcaaccgga tgacatgaaa 1020 acatggtatt ctcaggggcc ggaaggatac actgattatc cctctgcgac aagtggtccg 1080 Firmenich SA 108 aactaa 1086 Sequence Number (ID): 120 atgccgtccc tgtttgattc tatcgatctg ggcgcggtcc acgccgcaaa ccgcatcatt 60 atgtctccgc tgacgcgtgc tcgcgccacc gaaggtgctg tgccgacccc gctcatggtt 120 gaatattacg cccagcgcgc gggcgctggt ctgatcattt ctgaggccac cggtatctcc 180 cgtgaaggcc tcggttggcc gtgggctccg ggcatctgga gcgcggaaca ggtagcagcg 240 tggaaaccga tcactaaagc tgtccacgaa cgtggcggta agatcgtgtg ccaactgtgg 300 cacatgggtc gtatggtaca tagctctgtc accggtctgc aacctgtgtc cgcgtccccg 360 accacggcac cgggccagtc ccacacctac gaaggtaaga aaccatacga ggaagcacgt 420 gagctgcgtg tagatgagat cccacgcatc ctggcggact atgaaaacgc agcccgcaac 480 gctatcgagg ccggcttcga cggtgtacag attcacgccg ctaatggcta cctgattgac 540 gagttcctgc gcgacggtac taaccaccgt aaagatgaat atggcggtgc accggaaaat 600 cgtattcgcc tcctgcgtga ggttactgaa cgtgtagtgg cgactatcgg tgcagatcgt 660 acttctgtcc gtctgtcccc gaacggtgat actcagggca cggatgactc cgccccggaa 720 aaagtttttg taccggcagc taaagttctg caggatctgg gcgttgcctg gctggagctg 780 cgcgaaccag gcccagaagg caccttcggc aaaaccgatg aaccgaaact gagcccggaa 840 atccgcaagg ttttctctcg tccgctggtt ctgaaccagg actatactct ggaggatgcg 900 cagaaagcgg tgagctctgg cctcgccgac gcggtgtctt tcggccgtaa attcatcgcg 960 aacccagatc tgcctcgccg ttttgcggaa gagatcccgc tggccaaaga tgacatggcg 1020 acctggtact ctcaaggccc taagggttac accgattatc cgttcgcgga cgaataa 1077 Sequence Number (ID): 121 atgccgaacc tgttcgaccc gctgcagctg ggtccgatca ccctgccgaa ccgcgttatc 60 atggcaccgc tgacccgcct gcgtggtacc ccggatcaca tcccgacccc gctgatcgct 120 gaatactatg cccagcgtgc gtccgcaggt ctgatcattt ctgaaggtac cccggtttct 180 ccaatgggtg taggttatgc tcaagtcccg ggcatctggt ctgaacaaca gactgaacag 240 tggagccaca ttacgaccgc agtacacgcg gccggcggtc gtattttcgc ccagatctgg 300 cacgttggtc gcgtttctca cccgctgttc ctgaacggtc aacagccagt ggcaccgacc 360 gcactggccc cggaaggttt cgtgtccctg gtccgtccgc aacgcccatt cgaaacccct 420 cgtgctctgg atatcgctga aattcgttcc accatcgctg actacaaacg tggtgcgcag 480 aacgcgaaag cagcgggctt cgacggcgta gaactgcatg gcgcgaacgg ttacctgatc 540 gatcagttcc tgcagtccgg caccaaccac cgtacggacg cctatggtgg cccggttgaa 600 aaccgcgcac gtttcatgct ggaggctgta gatgctgtta gcgaagtatg gggcgcagac 660 cgcgtcggta tgcatctggc gccgcgtggt ggctatatga gcatctccga cgctaacccg 720 Firmenich SA 109 agcgaaacct tcggctatgt ctgggtaaac gtggtctggc gttcctgatg 780 tctcgcgaac atgagggtcc tgactggctg accccacagc tgaaacaaca gttcggtggc 840 gtgtacattg ccaacgaagg tttcacttac gaatccgcga acgccgcagt agaacgtggt 900 gactgtgacg ctgttggctt cggtaaactg ttcatttcta atcctgacct gccggctcgt 960 ttcgctcgcc aggcagaact gaccgcacct attccggaaa ccttctactc tcactctcct 1020 gagggttaca ttgattatcc ggcgctggcc taa 1053 Sequence Number (ID): 122 atgccgaccc tgttcgatcc gatccgtatc ggtgacctcg acctgccgaa tcgtgtcatt 60 atggctccgc tgacccgtag ccgcgctgtt ggcggtggcc gcgtaccgaa cgcgctgatg 120 gcagaatatt acgttcagcg tgccagcgct ggcctgatcc tgtccgaagc taccgcagtt 180 accccacaag gcgtgggtta cgcggacacc ccgggcatct ggtctgagga acaggttgcc 240 ggctggaaac acgtgactga cgcggtgcat gctgcaggcg gtcgcatctt tctgcagctg 300 tggcacgtcg gccgtatttc cgatccggtt ttcctggacg gtgaactccc ggttgcaccg 360 tctgcaatcg ctgcaggtgg ccatgttagc ctggttcgtc cgaaacgtgc attcgtgacc 420 ccgcgtgctc tggaaactga agagattcca ggtatcgtag ccgcgtatcg tcatggcgcg 480 gaaaacgcaa aagctgccgg tttcgatggc gttgaagttc acggtgcgaa cggctacctc 540 ctggaccagt tcctgcagga ctccaccaac cagcgtaacg acgcctacgg tggctccatt 600 gagaaccgtg ctcgtctgct cctggaggta actgacgctt gtatcgccgt ttggggtccg 660 gcacgcgtag gtgtacatct ggctccgcgt ggtgatgcgc actctatggg cgattctgat 720 ccagcggcca ccttcggtta tgtggcacgc gaactgggca aacgtggcat cgctttcatc 780 tgctcccgtg aagcgctggg cgacaaccgt ctgggtccgg aactgaaacg cgcgttcggc 840 ggtacctata ttgccaacga aaaaatgacc aaagctactg cggagcatgt tctgcaggca 900 ggtgaggccg atgcagtcgc gtttggtcag ctcttcatcg cgaacccgga cctccctcgc 960 cgtctgcagc tcgacgcacc gctgaacgcg ccgcagccag aaacctttta tcacccaggt 1020 gcggaaggtt acattgatta cccggcgctg gcataa 1056 Sequence Number (ID): 123 atgccgaccc tcttcgacac cctgacgctg ggtgatctga ccctgaaaaa tcgtatcgtg 60 atggcaccgc tgacccgctg tcgtgcagac gaaggtcgtg ttccaaatgc gatgatggca 120 gaatactatg ctcagcgttc tagcgcgggt ctgatcctga gcgaggcaac tagcgtaacg 180 gcaatgggcg ttggctatcc ggacacgcca ggcatctggt ccgatgcaca ggtacagggc 240 tggaagctga tcactgatgc ggtgcacgag gctggctccc gcattttcct gcagctgtgg 300 cacgtgggtc gtatctccga cccgagctat ctgaatggcg cgcagccggt cgccccgtct 360 gctgtgcgtc cggcaggtca tatctccctg gtgcgtccgc tgaaggacta cgacgaaccg 420 Firmenich SA 110 cgtgccctca ccctggctga gtcgtgcaag catatcgcca gggcgctatc 480 aacgccaaag ccgcaggctt cgatggtgtg cacatccacg gtgcaaacgg ctacctcctg 540 gatcagttcc tgcaggactc cacgaacctg cgtgacgatg agtacggcgg tagcctggaa 600 aaccgtgcgc gtctgatgct ggaagtcacc gatgcgtgca ttgacgtgtg gggtaaagac 660 cgtgtggcaa tgcatctggc gccgcgcatg gatgcgcacg acatgggcga ttctaaccgc 720 actgctacct tcggttatgt ggcgacggaa ctcggcaagc gcggtatcgc gttcatctct 780 acccgtgaac acgcagcgga tgactctatc accccgctca tcaaacagct gtttggcggt 840 ccggtgatcg ctaatgagaa attctccaag gcggaagcga atcagtggct ggccgagggt 900 aaagctgatg cagttgcctt tggtattccg tttatcgcta acccagacct gccgaaacgt 960 ctggagctgg acgcgccgct gaatgaaccg cgcaaagaac tgttttacgg caaaggtccg 1020 ctgggttata ccgactatcc gactctggct taa 1053 Sequence Number (ID): 124 atggccacga ttttcgaccc aatcaaactg ggcgatatcg aacttaaaaa ccggattatt 60 atggctccac tgactcgttg ccgggcggat gcgggtcgtg tgccgaatgc gctgatggca 120 gaatattatg ttcaacgtgc gtcagccggt ctcatccttt ccgaggcgac gagtgttacc 180 ccaatgggcg tgggttaccc agatacaccg ggaatctggt cgaacgatca agtccgtgga 240 tggagcaatg ttaccaaagc cattcatggc gcaggcggca aaattttcct gcagctgtgg 300 catgtcggtc gtatttcgca tccaagttat ctcaacggcg agacgccggt cgcgccgagc 360 gctattcagc caaagggtca cgttagcctg gtgcgtccct tagcggatta tccgacgccg 420 cgggccttag aaaccgcgga aatcgcggat atcgtggaag cttatcgtgt gggggcagaa 480 aacgcaaaag ccgccggctt tgacggtgta gaaattcatg gagcgaatgg ctatcttttg 540 gaccaatttc tgcaatcgag cacgaaccag cggaccgata gctatggtgg ctccctggaa 600 aatcgtgccc gtctgttact ggaagttacg gacgcggcga ttgaggtgtg gggtgccggg 660 cgggtcggag tgcatctggc acctcgggcg gacagtcatg atatgggcga cgagaatcgc 720 ttggaaacat tcagctatgt ggcgcgtgaa ttaggcaaac gcggtatcgc gtttatttgc 780 tcgcgtgaga aagagggcga tgatagtatt ggcccgcaac tgaaacaggc atttgggggg 840 ccgtatattg ccaacgaacg tttcacgaaa gattcagcga acgcttggct ggcggaaggc 900 aaagcggatg cagttgcctt cggtgtcccg tttatcgcga atcctgattt accagcccgc 960 ttgaaggcgg acgcgccgct gaatgaagca caccctgaaa cgttctacgg taaaggtccg 1020 gtgggttaca tcgactatcc cgttctctga 1050 Sequence Number (ID): 125 atggcgacca tttttgatcc gatcaaactg ggcgatctgg agctgtctaa ccgcattatc 60 atggccccgc tgacccgttg ccgtgctgat gaaggtcgtg ttccgaatgc gctgatggct 120 Firmenich SA 111 gaatattacg tgcagcgtgc gtccgccggc ctgattctgt ccgaagcaac tagcgttacc 180 ccgatgggcg ttggctatcc ggataccccg ggcatttggt ccaatgacca agtacgtggc 240 tggactaaca tcactaaagc tgtgcacgct gcaggcggta aaatcgtcct ccagctgtgg 300 catgtgggtc gtatttccca cccgctgtac ctgaatggtg aagccccggt agcgccgtcc 360 gcaattcagc cgaagggtca cgtaagcctg gtacgtccgc tggctgacta cccaactcca 420 cgtgctctgg aaaccgctga gatcgcagaa atcgtcgaag cgtaccgtac cggcgcggaa 480 aacgctaaag cggctggctt cgacggcgtt gaaattcatg gtgcgaacgg ttacctcctg 540 gaccagtttc tgcagagctc caccaaccag cgtaccgata actatggtgg ctctctggaa 600 aaccgtgcgc gtctgctcct ggaagttacc gacgcagcga ttgacgtttg gggcgcgggt 660 cgcgtaggcg tacatctggc accgcgtgca gattctcacg atatgggtga tgacaacctg 720 gctgaaacct ttacctacgt ggcccgtgaa ctgggtaaac gcggcattgc tttcatctgc 780 tctcgtgaga aagagggcgc tgatagcctg ggtccgcagc tgaaggaagc gttcggtggc 840 gcttacatcg cgaacgagcg tttcactaaa gactccgcca acgcctggct ggctgaaggt 900 aaagccgacg ctgtagcgtt tggcgtaccg ttcatcgcta atccggacct gccggctcgt 960 ctgaaagcag acgcaccgct gaatgaaccg cgtccggaac tgttctacgg taaaggtccg 1020 gtcggttata ttgactatcc gaccctgtaa 1050 Sequence Number (ID): 126 atgagctaca tgaacttcga tccgaaaccg ctgggcgaca ccaacatctt caaaccgatt 60 aaaatcggta ataacgaact gaagcaccgt gttgtgatgc ctgcgctgac ccgcatgcgt 120 gcgatcgcgc cgggtaacat tccgaacacg gaatgggcag aagagtacta tcgccagcgt 180 agccaatatc cgggcaccct gattatcact gaaggtactt tcccgagcgc gcagagcggc 240 ggttatccga acgtcccggg catctggtct aaggaacagc tggcagagtg gaaaaagatc 300 ttcaacgcaa tccacgaaaa caagtccttc gtttgggtac agctgtgggt gctgggtcgt 360 caggcatggc cggaggtgct gaagaaagag ggcctgcgtt acgattccgc tactgatgac 420 ctgtacatgg gcgaagagga aaaagaacgc gctctgaagg caaacaatcc gcagcacggt 480 atcaccaagg aggaaatcaa acaatatatc aaagagtatg ttgacgccgc taagaaagca 540 attgacgcag gtgctgatgg cgtgcagatc cactccgcga atggttacct cctgaaccag 600 ttcctggatc cgatctccaa caatcgtacg gacgaatacg gtggctctat tgaaaatcgc 660 gcccgtttta ccctggaggt tgtggacgct gttgtggacg cggttggcgc agagcgtacc 720 tctattcgtt tttctcctta tggtaccttt ggtaccatgt ctggcggtga aaacccgggt 780 atcgtcgcac aatacgctta tgtaatcggc gaactggaaa aacgtgcacg tgcaggtaag 840 cgtctggcgt tcatcgacct ggttgaacct cgtgtgaccg atccgtttct gccggaattc 900 gaaaaatggt ttaaagaagg tactaacgaa ttcatttatt ctatctggaa aggcccagtt 960 Firmenich SA 112 ctgcgtgtgg gtaactacgc gatcaggcga ccctggactc taagaaacct 1020 aacaccctga ttggctacgg tcgttctttt attgctaacc cggacctggt gtaccgcctg 1080 gagaagggcc tgccgctgaa caaatacgat cgtaacactt tctacacttt cactaaagaa 1140 ggctatactg attacccgtc ctacgaggaa tctgtggcca agggctacaa gaaagaggaa 1200 aaaaagtatt aa 1212 Sequence Number (ID): 127 atgtcctttg tgcaagattt taagccgatc gcgcttgctg acaccaaatt attcaagcca 60 attaagatcg gaaataacga gttggcgcac cgcgttgtaa tgccaccttt gacgcgtatg 120 cgtgcgaccc atccaggaaa tgtacctaat aaggattggg cggtagagta ttatgaccaa 180 cgttccaagc gtccaggcac gctgatcatt acagagggcg cctttcctag cgcgcaaagc 240 ggtggttatg acaatgtgcc tggcatttgg agcccagcgc aattggaaca atggaagaag 300 atctttgcga agatccacga gaataagtca ttcgtttggg tccaactgtg ggttcttggc 360 cgccagagtt tcgcggatac acttgcccgc gacggcttgc gttacgactc tgcttcagac 420 ggcgtgtata tggacgaaga gcaacgtgag cgtgccgtga agtccaacaa tcctcagcac 480 ggtctgacaa aggcggaaat caaacaatac atctcagagt acgtggacgc ggccaagaag 540 agtattgaag ccggggctga tggcgtggaa attcacagtg cgaacggata cctgttgaac 600 caatttctgg atcctattag taataaacgt actgacgagt atggtgggag catcgagaat 660 cgtgcgcgtt tcgttctgga agttgtggat gccgttacag aggccattgg ttgcgataaa 720 gttggtattc gtctgagccc ttatggcacg tttggtacca tgtcgggtgg gtcggagccg 780 cttatcgtgg cacaattcgc gtacgtgctc ggcgaattag aaaagcgcgg caaggctggt 840 aagcgcttaa gcttcgtgca ccttgtcgag ccgcgtgtta ccaacccgtt ctacaccgag 900 ggtcagggcg aatacacaga aggaacaaat gacttcgcct attcagtgtg gaaggggccc 960 atcattcgtg ccggcaattt ggctctccat cccgaggtag tcaagaagat ggttgaggac 1020 gaccgcactc tgatcgggta cggacgcttc tttatttcca atccggacat tgttgaccgt 1080 gtcgaaaagg gtttacccct taacaagtac aaccgtgata ccttctacgc gatgaccgcc 1140 aatggttacc ttgactaccc gacgtatgat gaggccgtca agcttggcta taagtga 1197 Sequence Number (ID): 128 atgcctttcg ttaaggggtt cgaacccatc tctctccgtg acacgaattt atttgaaccc 60 atcaaaatcg gtaataccca actcgcgcat cgtgctgtga tgccgccgtt aacgcgcatg 120 cgtgcgacgc atccggggaa catcccgaac aaggaatggg cagcggtcta ctatgggcag 180 cgtgcccaac gtcctgggac catgatcatc actgagggca ccttcatcag tccgcaagcc 240 ggtggctacg acaatgcgcc tgggatctgg tctgatgagc aagtggcaga atggaagaat 300 atctttctcg cgattcacga ttgccagagc ttcgcatggg tacagttgtg gagcctcggc 360 Firmenich SA 113 tgggcgtcat tcccagacgt gatggtcttc gctatgattg cgcctcagac 420 cgtgtatata tgaacgcaac tcttcaagaa aaggcgaagg acgccaacaa cttagagcac 480 tcactgacta aggacgatat taagcaatat attaaagact acatccatgc ggcaaagaat 540 tcaatcgccg ctggtgccga cggtgtggag attcacagcg caaacggcta tctgttaaat 600 cagtttctgg acccccatag caataaacgc accgacgagt atggcggtac gattgagaat 660 cgcgcccgtt tcacccttga ggtagtggac gccctgattg agacgattgg acctgagcgt 720 gttggactcc gccttagccc ttatggtacc tttaactcaa tgagcggtgg cgctgagcct 780 ggtatcattg cgcaatactc gtacgtcttg ggcgagttgg agaaacgtgc taaggccgga 840 aagcgcttag cgtttgtcca tcttgttgag cctcgcgtca ctgatccgtc gctggtcgag 900 ggcgagggtg agtatagcga gggcactaac gacttcgcat atagtatctg gaaaggtccg 960 attatccgcg cgggtaatta tgcgctccat cccgaggtgg tacgcgagca ggttaaggac 1020 ccacgcaccc tcattggata cggccgtttc tttatttcaa acccggacct tgtttaccgt 1080 ttggaagagg gtctgcctct caataagtac gaccgcagta ccttttatac catgtcagcc 1140 gaaggataca ctgattatcc aacctatgaa gaagcagttg acctcggttg gaataagaat 1200 tga 1203 Sequence Number (ID): 129 atgccattcg tgaaggactt taagccgcaa gctctgggcg atactaactt atttaagcct 60 attaagatcg gtaacaacga acttttacat cgcgccgtga tcccgccttt aacccgcatg 120 cgcgcgcaac accctggtaa catccctaac cgtgattggg ctgtggaata ttacgcccag 180 cgtgcgcaac gtcctggtac tttaatcatt acggaaggga cattccccag cccgcagagt 240 ggtggttacg ataacgcgcc cggcatttgg tcagaggagc aaatcaagga atggacgaag 300 atctttaaag cgatccacga gaacaaaagc ttcgcttggg tgcaactgtg ggttctcggt 360 tgggctgctt ttccagatac cctggcccgt gacggattac gctacgactc cgcctcagat 420 aacgtataca tgaacgcgga acaagaggag aaggcaaaga aggctaacaa cccacaacat 480 tctatcacga aggatgaaat caagcaatat gtaaaagagt acgtccaagc agccaagaat 540 agtatcgctg cgggagctga tggtgtagag atccattcgg ccaatggcta tctcctgaac 600 caattcttag acccacacag caataaccgc acagatgagt atggcggatc catcgaaaat 660 cgtgcacgct ttacccttga ggttgtggac gccgttgtgg acgccatcgg tcctgagaaa 720 gtcggcctgc gcttatcccc atacggcgtg tttaattcta tgtctggcgg agcggagact 780 ggcatcgttg cgcaatatgc gtacgtatta ggtgaattgg agcgccgcgc taaggcaggc 840 aagcgcttag cgtttgtaca cttagtggag cctcgtgtta ctaatccatt cttaacagag 900 ggtgagggcg agtacaatgg tggtagcaac aagttcgcct atagcatttg gaaagggcct 960 atcatccgtg ccggaaactt cgcattacac ccggaagtcg ttcgtgaaga agtcaaagac 1020 Firmenich SA 114 ccgcgtactc tgatcggata ttcatcagta atccggatct tgtggatcgc 1080 ctggagaaag gcttaccctt gaacaagtat gaccgcgaca cgttctacaa gatgtccgcc 1140 gaagggtata tcgattatcc tacatacgag gaagcgttaa agcttggctg ggataagaac 1200 taa 1203 Sequence Number (ID): 130 atgagctttg taaaggattt caagccacag gcgcttggtg acactaactt attcaagcca 60 120 cgcgcattgc acccggggaa tattccgaat cgtgattggg cggttgaata ctatacccag 180 cgtgcgcagc gtcccggcac gatgattatt actgagggag cttttatttc tcctcaagcg 240 ggtgggtacg ataatgcgcc gggagtatgg agcgaggaac agatggtgga atggacgaaa 300 atcttcaacg cgatccatga aaagaagagt tttgtctggg ttcagttatg ggtactgggg 360 tgggctgcct ttcctgataa cttagcacgt gacggtttgc gttacgactc cgctagcgat 420 aatgtattta tggacgccga gcaagaagcc aaggcaaaga aggcgaacaa ccctcaacac 480 tcacttacta aagatgagat caagcagtac atcaaggagt acgtgcaggc cgccaagaat 540 agtatcgccg ccggcgctga cggggtagag attcacagcg cgaatggata ccttctcaac 600 caatttctgg acccgcattc gaacacgcgc accgacgagt acggcggtag catcgagaac 660 cgcgcgcgtt ttactttaga ggtggtagat gcattggttg aggccatcgg tcatgagaag 720 gtcggccttc gcctctcgcc gtacggggtt ttcaattcta tgtccggtgg cgccgagacc 780 ggcattgtgg cccaatatgc ctacgttgcg ggcgaattag agaagcgtgc gaaggcaggc 840 aagcgcttag cctttgttca cttagtggag cctcgcgtga ccaacccgtt tctgaccgag 900 ggtgagggcg agtacgaagg cgggagcaat gactttgtgt acagtatctg gaagggaccg 960 gtcattcgcg ctggtaattt tgcgcttcac cccgaggtag tacgcgaaga agtgaaggac 1020 aaacgtacac ttatcggtta tggccgtttc ttcatttcta atccggatct cgtggatcgc 1080 ttagagaagg gcttaccgtt aaacaagtac gaccgcgata ctttctacca aatgtctgca 1140 catgggtaca ttgactaccc aacgtacgaa gaggccttaa agctcggttg ggacaagaag 1200 taa 1203 Sequence Number (ID): 131 atgaccgtag gcctcgaaca gtctaacctg ttcaaaccga tcaccatcgg caaaaacact 60 ctggaccagc gtgttgcttt cgctccgact acccgttttc gcgcggccga cgatcatacg 120 ccgagcgacc tgatgctcca atactattct gaccgtgcgc aggcaccggg ttccctcctg 180 attaccgaag ccacgtttat ttctccgcgt gctggcctgt atccgaacat tccgggtatc 240 tggaatgaaa aacatgtgca gggttggaag aaaatcacgg atgcggttca cgcaaaaggt 300 tcctacatgg cctgccaatt ctggttcctg ggtcgtgtcg gctctccgga gctcctgaaa 360 Firmenich SA 115 aagcacggtc tggatctgat gcgctgtatg aatctgagga aagcaagaaa 420 gcggctgaag cggctggcaa cccggttcgt gcgctcactg aaaaagaaat caagggtatc 480 atttacgagg attacaaaaa cgccgcgatc aacgctatgg aggcaggctt cgactacgtg 540 gaaatccact ccgcccacgg ttatatgctg gatcagttcc tgcagccggc gaccaatcag 600 cgcaccgata actatggcgg ttctattgaa aaacgtgctc gtatcgtgct ggagatcatt 660 gacctcctga gcgacaccat cggcgctgag aagctggcaa tccgcctctc tccgtgggcc 720 aaatttcaag gtatgaaagc tgaacaggac accgtgcatc cgatcacgac cttctcttat 780 gtagttaacg aactgcagaa gcgcgcaaat aacggtaaac agctggctta cctgtctctg 840 gtcgaaccgc gtgtacaggg taacctggac gttaacacga gcgacattgt tggttccaac 900 gatttcatca agaaactgtg gaaaggtgct attctgcagt ctggtaacta tacttatgat 960 tctcctgaat tcaaactcct gaaggcagac gtaaacggcg acaaccgtac gatgattggc 1020 ttctctcgct atttcactag caacccggac ctgatcgacc gcctgaaaaa gggtctggag 1080 ctgaccccgt acgtccgttc cctgttttac gccaccaata actacggtta caacaccttc 1140 gcgaactacg gtaaagaact gcaattcgat ccgaagaaag aggaaaaacg ccgtccggtg 1200 tctctgattt aa 1212 Sequence Number (ID): 132 atgagctccg tgaagatcag cccattaaaa gactccgagg cgtttcagag tattaaagtt 60 ggaaataata cgctgcaaac caagatcgtt tatccgccga ccacccgctt ccgtgccctc 120 gaagaccaca cgccgtccga cctgcagttg cagtattacg gcgaccgttc aacattcccg 180 gggactctct taattactga ggctactttc gtgagtccgc aggcttcggg ctatgaagga 240 gcagcaccgg ggatttggac ggacaagcac gcgaaggcct ggaaggtcat taccgacaag 300 gtccacgcca acggtagttt cgtatcgacc cagcttattt tcttgggtcg tgtggctgac 360 cccgcggtca tgaaaacccg tggcttaaac ccggtgtcag catccgccac ctatgagagc 420 gatgccgcga aagaggccgc cgaggcagtc ggcaatcctg ttcgtgcact gacaacccaa 480 gaggtgaagg atctggtgta cgagacgtac actaacgcag cacaaaaggc catggatgcg 540 ggctttgact acattgagct tcacgcggca catgggtacc ttttagatca atttctgcaa 600 ccgtgtacaa accaacgcac cgacgagtat ggtggtagca tcgaaaaccg tgcccgctta 660 attttggaac tgatcgatca tttgtctact attgtcggtg cggataaaat cggtattcgt 720 atctcaccgt gggcgacttt tcaaaacatg aaggcccata aagacacggt acatccttta 780 accacgtttt catatttagt tcatgaactt caacaacgtg ccgataaagg gcagggcatc 840 gcatacatct ccgtggttga gccacgcgtt tcagggaacg tggatgtatc ggaagaggat 900 caggcgggtg acaacgaatt tgtcagcaag atttggaaag gcgtgatctt gaaggccgga 960 aactactctt acgacgcgcc ggagttcaag accctgaaag aggacatcgc cgataagcgt 1020 Firmenich SA 116 accttagttg gattttcgcg tcaaacccga acttagtctg gaagctgcgt 1080 gatggaatcg acctggtgcc atacgatcgc aatacctttt attctgataa taactacggt 1140 tataacacat tcagtatgga ctccgaagag gtggataagg aactggagat caaacgtgta 1200 cctagcgcga tcgaggcgct ttaa 1224 Sequence Number (ID): 133 MTKVLAVLYP DPVDGFPPKY VRDDIPKITH YPDGSTVPTP EGIDFKPGEL LGSVSGGLGL 60 KKYLESKGVE FVVTSDKEGP DSVFEKELPT ADVVISQPFW PAYLTADLID KAKKLKLAIT 120 AGIGSDHVDL NAANEHNITV AEVTYSNSVS VAEAEVMQLL ALVRNFIPAH DIVKAGGWNI 180 ADAVSRAYDL EGMTVGVIGA GRIGRAVLER LKPFGVKLVY NQRHQLPDEV ENELGLTYFP 240 DVHEMVKVVD AVVLAAPLHA QTYHLFNDEV LATMKRGAYI VNNSRGEEVD RDAIVRALNS 300 GQIGGYSGDV WYPQPAPKDH PWRTMPNEAM TPHMSGTTLS AQARYAAGAR EILEDFLEDK 360 PIRPEYLIAQ GGSLAGTGAK SYTVKKGEET PGSGEAEK 398 Sequence Number (ID): 134 MAKVLCVLYD DPVDGYPKTY ARDDLPKIDH YPGGQILPTP KAIDFTPGQL LGSVSGELGL 60 REYLESNGHT LVVTSDKDGP DSVFERELVD ADVVISQPFW PAYLTPERIA KAKNLKLALT 120 AGIGSDHVDL QSAIDRNVTV AEVTYSNSIS VAEHVVMMIL SLVRNYLPSH EWARKGGWNI 180 ADCVSHAYDL EAMHVGTVGA GRIGLAVLRR LAPFDVHLHY TQRHRLPESV EKELNLTWHA 240 TREDMYPVCD VVTLNVPLHP ETEHMINDET LKLFKRGAYI VNTARGKLCD RDAVARALES 300 GRLAGYAGDV WFPQPAPKDH PWRTMPYNGM TPHISGTTLT AQARYAAGTR EILECFFEGR 360 PIRDEYLIVQ GGALAGTGAH SYSKGNATGG SEEAAKFKKA V 401 Sequence Number (ID): 135 atgaccaaag tgttagcagt tctgtatcca gatccagtgg atggtttccc accaaaatat 60 gtgcgggacg acattccaaa gattacccac tatccagatg gctcgacggt tccgacacct 120 gaggggattg acttcaagcc gggtgagtta ttgggcagtg tgtctggtgg cttgggactg 180 aagaaatatt tggaatctaa aggtgttgaa tttgtggtca cttcagacaa ggaaggcccc 240 gattcagtat ttgaaaagga acttccaacc gctgacgttg tgatttccca accattctgg 300 ccagcctatc tgacagctga tttaattgat aaagccaaga aattaaaatt agcgatcact 360 gccgggattg gttcagatca cgttgatttg aacgctgcca atgagcacaa tattaccgtt 420 gccgaagtca cttatagcaa cagtgtcagt gtggctgaag ctgaagtcat gcagttattg 480 gcattagttc gaaacttcat tccggctcac gacattgtta aagctggcgg ctggaacatc 540 gctgacgccg tttcacgggc ctatgatttg gaaggcatga ccgtcggcgt gatcggtgct 600 ggtcgaattg gccgggccgt actggaacgg ttaaaaccat ttggggttaa attagtttac 660 aaccagcgtc atcaattacc tgatgaagtt gaaaatgagc tgggactgac ctatttccct 720 Firmenich SA 117 gacgttcatg aaatggtcaa gccgttgtct tagctgcacc actgcacgct 780 cagacctacc acctgtttaa cgacgaggtg ctcgctacta tgaaacgtgg ggcttacatc 840 gttaacaaca gtcgtggtga agaagttgat cgagacgcga ttgtgcgggc cctgaattct 900 ggtcaaattg gcggctactc tggggatgtt tggtacccac agccggcacc aaaggatcac 960 ccttggcgga ccatgccgaa tgaagctatg accccacata tgtccggaac aactttatct 1020 gcccaggcac gatacgcagc cggcgctcgg gaaattctcg aagacttctt agaggacaaa 1080 ccgatccgtc ctgaatacct gattgcccaa ggcggtagtt tagctggaac gggtgctaag 1140 tcctacactg tcaagaaagg tgaggagaca cccggaagtg gggaagctga gaagtag 1197 Sequence Number (ID): 136 atggctaaag ttctgtgcgt tctctacgat gacccggtgg acggctaccc taaaacctac 60 gcgcgcgatg acctgccgaa aatcgatcac tacccgggcg gtcagattct gccaacccct 120 aaagcgattg acttcactcc tggtcagctc ctgggctccg tgtctggtga actgggcctc 180 cgtgaatatc tggaatccaa cggtcatacc ctggtggtta ccagcgacaa ggacggtccg 240 gacagcgttt ttgagcgtga actcgttgac gcggacgtag tgatctctca gccattctgg 300 ccagcttacc tgaccccgga gcgcatcgcc aaagcaaaaa acctgaaact ggctctgacc 360 gctggcatcg gttccgacca cgttgacctc cagtccgcca tcgaccgcaa cgtaaccgtg 420 gccgaagtta cttactctaa cagcattagc gtagcagaac acgtggttat gatgatcctg 480 agcctggtgc gcaattacct cccatcccac gaatgggcgc gtaaaggcgg ttggaacatc 540 gcagattgcg tcagccacgc gtatgatctg gaagcgatgc acgtaggtac cgtgggcgcg 600 ggtcgtatcg gcctggctgt cctgcgccgt ctggcaccgt ttgacgtaca cctgcactac 660 acccagcgtc accgcctccc ggaatccgtt gagaaggaac tcaacctgac gtggcacgca 720 acccgtgaag atatgtaccc ggtttgtgat gtggttaccc tgaacgtgcc tctgcaccct 780 gaaaccgaac acatgatcaa tgacgaaacc ctgaaactgt tcaaacgtgg cgcttatatt 840 gttaacactg ctcgtggtaa actgtgtgac cgcgacgcgg ttgctcgtgc cctggaaagc 900 ggccgcctcg cgggctacgc cggcgatgtt tggttcccgc agccggctcc gaaagaccac 960 ccttggcgca cgatgcctta caacggcatg acccctcata tctctggtac taccctgacc 1020 gcacaagccc gttatgctgc gggcacccgt gaaatcctgg agtgtttttt cgaaggtcgt 1080 cctatccgcg atgaatacct gattgttcag ggtggcgcac tcgccggcac cggtgctcac 1140 tcctatagca aaggcaatgc aacgggtggc tctgaagagg ctgcaaaatt caagaaagca 1200 gtgtaa 1206 Sequence Number (ID): 137 atgactaagg tgctggctgt tctgtacccg gacccggtgg atggcttccc accgaaatac 60 gttcgtgatg acatcccgaa aatcacccat tacccggatg gcagcaccgt gccgactccg 120 Firmenich SA 118 gagggtatcg atttcaagcc ctgggttccg tatccggtgg cctgggtctg 180 aagaaatacc tggaatccaa aggtgttgaa ttcgtcgtaa cctctgacaa agaaggcccg 240 gactctgttt ttgaaaagga gctcccgacc gctgacgtgg taatctctca gccgttctgg 300 ccggcttacc tgaccgcaga tctcatcgac aaggccaaga aactgaagct ggcgatcacc 360 gccggtatcg gcagcgatca cgtggacctg aacgccgcga acgagcacaa tatcactgtt 420 gctgaagtta cttatagcaa cagcgttagc gttgcggaag cagaagtcat gcagctcctg 480 gctctggttc gcaatttcat ccctgcacac gacatcgtca aagctggtgg ctggaacatc 540 gcagatgccg tgtctcgtgc ctacgacctg gaaggcatga ccgtaggtgt aatcggtgct 600 ggccgcatcg gtcgcgcggt tctggaacgc ctgaaaccgt tcggtgtgaa actggtatac 660 aaccagcgtc atcagctgcc ggatgaggtc gaaaacgaac tgggtctgac ttacttcccg 720 gatgttcacg aaatggtaaa ggtagttgac gcggtggttc tggccgcgcc gctgcacgcc 780 caaacttacc acctgttcaa cgacgaggtg ctggcgacca tgaaacgcgg tgcctacatc 840 gttaataact ctcgtggcga ggaagttgat cgtgatgcga tcgtacgtgc gctgaactct 900 ggccaaatcg gtggctactc tggtgacgtg tggtatccgc agccagctcc taaagaccat 960 ccttggcgta ctatgcctaa cgaggcgatg actccgcaca tgtccggtac cactctgtcc 1020 gctcaggctc gctatgctgc gggtgctcgc gaaatcctgg aagatttcct ggaggataaa 1080 ccaatccgcc cagagtatct gatcgcgcag ggcggttccc tggcgggtac tggcgcgaaa 1140 agctacaccg tgaagaaagg tgaggaaact ccgggtagcg gcgaagccga aaaataa 1197 Sequence Number (ID): 138 atggctaaag tactgtgcgt gctgtacgat gacccggttg acggttaccc aaaaacctac 60 gcacgtgatg acctgccgaa aattgaccac tacccgggtg gccagatcct gccgaccccg 120 aaagcgatcg acttcacccc tggccagctc ctgggttctg tttctggtga gctgggcctg 180 cgtgaatatc tggagagcaa cggtcatacc ctggtcgtga cctctgataa agacggcccg 240 gattctgtgt tcgaacgtga gctggttgac gctgatgtcg tgatctccca accattttgg 300 ccggcgtatc tgacccctga gcgcattgca aaagccaaga acctcaaact ggcgctgacg 360 gcgggtattg gttctgacca cgtagacctg cagagcgcga tcgaccgtaa cgtgaccgtg 420 gcagaagtca cctactccaa cagcatttcc gttgccgaac acgtagttat gatgattctg 480 agcctcgtgc gtaactacct gccttctcac gaatgggctc gtaaaggtgg ctggaacatc 540 gcagattgtg taagccacgc atacgacctg gaagcgatgc acgtaggtac cgttggcgcg 600 ggtcgcatcg gtctggcggt tctgcgccgt ctggcgcctt ttgacgttca cctgcactac 660 actcagcgtc accgcctccc ggaaagcgtg gaaaaagaac tgaacctcac ctggcatgct 720 acccgtgaag acatgtaccc ggtatgcgac gtggtaaccc tgaatgttcc gctgcatccg 780 gaaaccgaac acatgattaa cgacgaaacc ctgaagctct tcaaacgtgg cgcctacatc 840 Firmenich SA 119 gttaacactg cgcgtggcaa cgtgatgccg tggcacgcgc actggaatcc 900 ggtcgtctgg caggctacgc gggcgatgtc tggttcccgc agcctgcacc gaaagaccac 960 ccttggcgca ctatgcctta caacggtatg accccgcaca tttctggtac taccctgacc 1020 gctcaagcac gttatgctgc aggcacccgc gaaatcctgg agtgtttctt tgaaggccgt 1080 ccgatccgtg acgaatatct gatcgttcag ggtggcgctc tggcaggtac cggtgcgcac 1140 agctactcta agggcaacgc gacgggcggt tctgaggaag ccgcgaaatt taagaaagcg 1200 gtataa 1206

Claims

Firmenich SA 120 Claims 1. A process for the reduction by hydrogenation of conjugated dienal of formula in the form of any and wherein each R1, 23R and R , a atom, a C1-3 alkoxy group, a C1-6alkyl group or a C2-6alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8 cycloalkyl or C5-8cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; into a deconjugated enal of formula in the form of anyand wherein R1to R6have the same meaning as defined in formula (I); said process being carried out in the presence of an oxidoreductase.

2. The process according to claim 1, wherein the oxidoreductase enzyme is an ene reductase.

3. The process according to claim 2, wherein the ene reductase enzyme has at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity of any of SEQ ID NOs: 1 to 44.Firmenich SA 121 4. The process according to any the previous claims, wherein the reduction is performed in the presence of a cofactor; preferably the cofactor is selected from the group of NADPH, NADP+, NADH and NAD+.

5. The process according to any one of the previous claims, wherein the reduction is performed in the presence of a cofactor regeneration system.

6. The process according to any one of the previous claims, wherein the process is an in vivo or in vitro process.

7. The process according to any one of the previous claims, wherein R5is a methyl group; R4and R6are hydrogen atoms and R1, R2and R3, independently from each other, represent a hydrogen atom or a C1-3alkyl group.

8. The process according to any one of the previous claims, wherein the compound of formula (I) is of formula in the form of any and wherein each R1and R2have the same as or claim 7; and said compound of formula (II) is of formula in the form of and wherein each R1and R2have the same as or claim 7.

9. A process for the preparation of a compound of formulaFirmenich SA 122 in the form of any one of its or a mixture thereof, and wherein each R1, R2and R3, independently from each other, represent a hydrogen atom, a C1-3alkoxy group, a C1-6 alkyl group or a C2-6 alkenyl group, each optionally substituted by a hydroxy or C1-3alkoxy group; or R1and R2, are taken together and form a C3-8cycloalkyl or C5-8 cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; comprising the steps of a) converting a compound of formula in the form ofthereof, and wherein R1, R2, R3,R4and R5have the same meaning as defined in formula (I); into an acetal of formula in thethereof, and wherein R1, R2, R3,R4and R5have the same meaning as defined in formula (I); Raand Rb, independently from each other, represent a C1-4 alkyl group or Raand Rb, when taken together, represent a C2-5alkanediyl group; b) treating the acetal obtained in step a) with an acid and a compound of formula R6-CH=CH-ORc; wherein R6has the same meaning as defined in formula (I) and Rcrepresents a C1-4alkyl group; to obtain a compound of formulaFirmenich SA 123 in the formthereof, and wherein R1, R2, R3, R4, R5, R6, Ra, Rband Rchave the same meaning as defined above; and c) treating the compound of formula (V) with an acid to obtain a compound of formula (I).

10. The process according to claim 9, wherein Raand Rb, independently from each other, represent a C1-3alkyl group and Rcis a methyl or ethyl group; preferably Raand Rb, independently from each other, represent a methyl group.

11. The process according to any one of claims 9 to 10, wherein step a) is carried out in the presence of an acid and a reagent selected from the group consisting of C1-4trialkyl orthoformate, C1-4 alcohol and C2-5 diol.

12. The process according to any one of claims 9 to 11, wherein the acid used in step b) is selected from the group consisting of boron trifluoride complexes, anhydrous zinc chloride, and para toluene sulfonic acid.

13. The process according to any one of claims 9 to 12, wherein the acid used in step c) is selected from the group consisting of formic acid, acetic acid, aqueous acetic acid, propionic acid, aqueous sulfuric acid, sulfuric acid and aqueous hydrochloric acid.

14. A compound of formulaFirmenich SA 124 in the form of the1 2reof, and wherein R , R and R3, independently from each other, represent a hydrogen atom, a C1-3alkoxy group, a C1-6 alkyl group or a C2-6 alkenyl group, each optionally substituted by a hydroxy or C1-3alkoxy group; or R1and R2, are taken together and form a C3-8cycloalkyl or C5-8 cycloalkenyl group; R4and R5, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4 alkyl group or Raand Rb, when taken together, represent a C2-5alkanediyl group.

15. A compound of formula in the form of and wherein R1 2, R and R3, independently from each other, represent a hydrogen atom, a C1-3 alkoxy group, a C1-6alkyl group or a C2-6alkenyl group, each optionally substituted by a hydroxy or C1-3 alkoxy group; or R1and R2, are taken together and form a C3-8 cycloalkyl or C5-8cycloalkenyl group; R4, R5and R6, independently from each other, are a hydrogen atom, a methyl or an ethyl group; Raand Rb, independently from each other, represent a C1-4alkyl group or Raand Rb, when taken together, represent a C2-5 alkanediyl group; Rcrepresents a C1-4 alkyl group.

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