Devices, systems, and methods for imparting mechanical strain to samples including biological samples

EP4747601A2Pending Publication Date: 2026-05-27UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION
0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION
Filing Date
2024-07-18
Publication Date
2026-05-27

AI Technical Summary

Technical Problem

Current devices and systems for applying mechanical strain to biological samples are not well-suited for high-resolution confocal live-cell microscopy, as they are often bulky, heavy, and limited in their ability to apply controlled, high strains.

Method used

A system comprising a cassette with a stretchable sample substrate connected between end members, an actuator assembly to control the width of the gap between the end members, and a microscope stage assembly that allows for high-resolution imaging during strain application.

Benefits of technology

Enables the application of controlled mechanical strain to biological samples while allowing for high-resolution live-cell imaging, facilitating the study of mechanical cues in tissue remodeling and development.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure US2024038560_23012025_PF_FP_ABST
    Figure US2024038560_23012025_PF_FP_ABST
Patent Text Reader

Abstract

A system includes a cassette including a. first end member spaced from a second end member and a sample substrate, which is stretchable, connected between the first end member and the second end member so that a. portion of the sample substrate extends across a gap between the first end member and the second end member. The sample substrate is adapted to have a sample deposited on the portion thereof which extends across the gap. The first end member includes a first cooperating abutment member. The system also includes an assembly including a body having a sample chamber to removably receive the cassette therein and a cassette interface. The cassette interface includes an abutment member extending to contact the first cooperating abutment member. The system further includes a first actuator in connection with the body to impart motion to the first cooperating abutment member.
Need to check novelty before this filing date? Find Prior Art