5-beta stereoselective reductions of 3-ketochol-4-enoic acid and derivatives thereof
Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- SANDHILL ONE LLC
- Filing Date
- 2024-09-11
- Publication Date
- 2026-06-24
AI Technical Summary
Current methods for synthesizing cholic acid derivatives are cumbersome and inefficient, often resulting in significant amounts of 5-alpha impurities during the reduction of the 4,5-double bond in 3-keto-chol-4-enoic acids.
The development of novel enzymatic and catalytic methods to reduce the 4,5-double bond of 3-keto-chol-4-enoic acids, preferentially producing 5-beta products, using enzymes such as At5pStR or its analogs with high sequence identity, and employing reaction conditions suitable for hydrogenation catalysts in trickle bed reactors.
These methods achieve high stereoselectivity and efficiency in producing cholic acid derivatives like ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA), with reduced 5-alpha impurities, thereby improving the overall process efficiency.
Smart Images
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