TOOL FOR PENETRATION OF ANTI-HAIR LOSS COSMETICS AND KIT USING THIS TOOL

Abstract

TOOL FOR PENETRATION OF ANTI-HAIR LOSS COSMETICS AND KIT USING SAME The objective of the present invention is to provide a personal-use tool for penetration of anti-hair loss cosmetics and a personal-use kit capable of improving the penetration of a cosmetic-grade anti-hair loss agent into the skin. The tool according to the present invention comprises a handle, a holder, and a microstructured network. The holder is configured to be connected to the handle. The microstructured network is placed on the holder. The microstructured network is configured to abrade the skin. The kit according to the present invention is a kit in which the tool according to the present invention and the anti-hair loss cosmetics according to the present invention are combined. The anti-hair loss cosmetics include one or more anti-hair loss agents. The one or more anti-hair loss agents include at least 2,4-diaminopyrimidine 3-N-oxide or a derivative thereof. Figure for abstract: 2

Description

Title of the invention: TOOL FOR THE PENETRATION OF ANTI-HAIR LOSS COSMETICS AND KIT USING THIS TOOL Technical field

[0001] The present invention relates to a tool for the penetration of anti-hair loss cosmetics and a kit using this tool. More particularly, the present invention relates to a method for improving the penetration of a cosmetic-grade anti-hair loss agent into the skin by performing a superficial restructuring of the skin.

[0002] Context of the art

[0003] Hair growth and renewal are mainly determined by the activity of hair follicles and their matrix environment. Natural hair loss or shedding can be estimated on average at a few hundred hairs per day for a normal physiological state. The physical renewal process of hair undergoes a natural evolution with aging. The hair becomes finer as its recycling cycle shortens. It is also known that certain other factors such as hormonal imbalance, physiological stress, etc., can accentuate the phenomenon.

[0004] In order to improve this alopecia, pharmaceutical grade agents for the treatment of alopecia have been used. The most popular agents for treating alopecia are minoxidil and finasteride.

[0005] Patent EPI 352 629 proposes pyridine-dicarboxylic acid derivatives. Patent EPI 352 629 proposes using pyridine-dicarboxylic acid derivatives to induce and / or stimulate the growth of human keratin fibers such as hair or eyelashes, and / or slow down their loss and / or increase their density. These derivatives are generally proposed and formulated in the form of a hydroalcoholic lotion to be applied to the scalp.

[0006] Document FR 3 044 550 A1 proposes a gelled composition of agents for the treatment of alopecia. The gelled composition of agents for the treatment of alopecia allows for more convenient use by avoiding dripping.

[0007] In order to fully exert the effect of alopecia treatment agents, it is very important to allow the alopecia treatment agents to penetrate into the skin.

[0008] Penetration of alopecia treatment agents may be enhanced by mechanical disruption of the skin using mechanical tools such as collagen induction therapy (microneedling), dermabrasion or by energy such as iontophoresis, electroporation, etc.

[0009] In particular, medical-grade microneedles have been widely used in combination with minoxidil and have been reported to enhance the efficacy of minoxidil. Medical-grade microneedles are popular in medical institutions such as dermatology offices and beauty clinics to treat hair loss-related problems such as alopecia.

[0010] Patent EP 3 178 465 A1 proposes combining a disruption of the integument such as microdermabrasion with a hair activating agent such as minoxidil.

[0011] However, if the microdermabrasion described in EP 3 178 465 A1 is used, since the targeted depth of disruption is deep (100 to 150 microns), the microdermabrasion described in EP 3 178 465 A1 can only be limited to cosmetic processes performed by experts in medical institutions such as dermatology practices and beauty clinics due to the risk of side effects.

[0012] On the other hand, there is a need for individuals to perform a beauty process that improves the penetration of agents into the skin for personal use as well as at home.

[0013] Cosmetic grade hair loss agents that are easy to handle by individuals have gained popularity in recent decades due to the low risk of side effects and the possibility of use by consumers themselves.

[0014] However, the current situation is that a beauty process capable of improving the skin penetration of cosmetic-grade anti-hair loss agents for personal use has not yet been developed. disclosure of the invention

[0015] In consideration of the above-mentioned problems of the conventional art, an object of the present invention is to provide a method for personal use for improving the penetration into the skin of a cosmetic-grade anti-hair loss agent.

[0016] Through a thorough study of this problem, the inventor realized that dandruff is the main cause of hindrance to the penetration of cosmetic-grade anti-hair loss agents into the skin. The inventor also realized that dandruff can be easily removed by a method for personal use. Based on these findings, the inventor realized that the skin penetration of cosmetic-grade anti-hair loss agents can be easily improved by superficial restructuring of the scalp from the surface of the scalp to a depth of 50 microns in order to destroy dandruff before it appears on the scalp. Accordingly, the present invention was fabricated by the inventor.

[0017] (Tool for the penetration of anti-hair loss cosmetics)

[0018] To achieve the aforementioned object, a tool for penetrating anti-hair loss cosmetics according to the present invention comprises a handle, a support, and a microstructured network. The support is connected to the handle. The microstructured network may be a micro / nano-structured network that is placed on the support. The microstructured network is configured to abrade the skin.

[0019] In a preferred embodiment of the present invention, the microstructured network may be a microstructured network capable of superficially restructuring the skin to a desired depth (up to 50 microns deep from the skin surface).

[0020] In a preferred embodiment of the present invention, a drive mechanism is provided in the handle. The drive mechanism is connected to the holder. The drive mechanism is configured to reciprocate the network placed on the holder relative to the handle in a direction perpendicular to the network.

[0021] In a preferred embodiment of the present invention, the handle has a hollow portion. The drive mechanism is provided in the hollow portion of the handle.

[0022] In a preferred embodiment of the present invention, the height of the microstructure of the network is 50 to 500 microns. In other words, if the height of the microstructure is less than 50 microns, it may not be possible to effect satisfactory surface restructuring of the skin and it may then not be possible to effect satisfactory penetration of the cosmetic grade anti-hair loss agents into the skin. On the other hand, if the height of the microstructure exceeds 500 microns, the skin may be scraped too deeply beyond the desired depth, which may make it difficult to use in a cosmetic process for personal use.In a preferred embodiment of the present invention, the height of the microstructure is preferably in the range of 50 to 500 microns, preferably 50 to 300 microns, more preferably 50 to 150 microns, in order to achieve both a satisfactory surface restructuring effect of the skin and cosmetic processes for personal use. In a preferred embodiment of the present invention, the aspect ratio of the microstructure is preferably in the range of 0.5 to 10, preferably 0.5 to 5, more preferably 1 to 3.

[0023] In a preferred embodiment of the present invention, the microstructure of the network may have a pointed shape. The microstructure is made up of a plurality of microstructures. The range between two adjacent microstructures is from 200 to 800 microns. Namely, if the distance between two adjacent microstructures is less than 200 microns, it may not be possible to achieve the desired surface restructuring of the skin and it may not be possible to achieve penetration sufficient amount of the cosmetic-grade anti-hair loss agent into the skin. On the other hand, if the distance between two adjacent microstructures exceeds 800 microns, the skin may be scraped too deeply beyond the desired depth, which may make it difficult to use the tool in a personal cosmetic process. In a preferred embodiment of the present invention, the distance between two adjacent microstructures is preferably 200 to 800 microns, in order to achieve both a satisfactory surface restructuring effect of the skin and personal cosmetic processes.

[0024] In a preferred embodiment of the present invention, the microstructure is configured to abrade the skin from the skin surface to a depth of 50 microns.

[0025] In a preferred embodiment of the present invention, the network is configured to be fluidly connected to the anti-hair loss cosmetics in order to be able to apply the anti-hair loss cosmetics from the network to the skin.

[0026] In a preferred embodiment of the present invention, the handle has a hollow reservoir portion for containing the anti-hair loss cosmetics.

[0027] (Kit)

[0028] Furthermore, through in-depth study of the combination with the tool for penetration of anti-hair loss cosmetics according to the present invention, the inventor realized that among many cosmetic-grade anti-hair loss agents, the penetration of 2,4-diaminopyrimidine 3-N-oxide or a derivative thereof into the skin could be sufficiently improved, and the anti-hair loss effect of 2,4-diaminopyrimidine 3-N-oxide or a derivative thereof could be remarkably achieved. Therefore, a kit according to the present invention was manufactured by the inventor.

[0029] To achieve the above-mentioned object, a kit according to the present application is a kit in which the tool for penetrating anti-hair loss cosmetics according to the present invention and anti-hair loss cosmetics are combined. The anti-hair loss cosmetics include one or more anti-hair loss agents. The one or more anti-hair loss agents include at least 2,4-diaminopyrimidine 3-N-oxide or a derivative thereof.

[0030] In a preferred embodiment of the kit according to the present invention, the tool for penetrating anti-hair loss cosmetics is configured to abrade the skin to a depth of 50 microns. The anti-hair loss cosmetics can be applied to the skin.

[0031] The term "anti-hair loss" as used herein refers to those including dandruff prevention, hair growth, and hair loss prevention.

[0032] The term "skin" as used herein means the scalp or the like.

[0033] The term "personal use" used in the present invention refers to the case where a user of the tool according to the present invention performs a beauty process on the user, and to the case where a user of the tool according to the present invention performs a beauty process on a person different from the user. Brief description of the drawings

[0034] [Fig-1] [Fig. 1] shows a comparison result between the skin of a reference group on which the tool according to an embodiment of the present invention was not applied and the skin of the treatment group on which the tool according to an embodiment of the present invention was applied.

[0035] [Fig.2] [Fig.2] is an explanatory diagram of a schematic configuration of a A tool for penetrating anti-hair loss cosmetics according to a first embodiment of the present invention, which is suitable for use in a kit according to an embodiment of the present invention.

[0036] [Fig.3] [Fig.3] is an explanatory diagram of a schematic configuration of a tool for penetration of anti-hair loss cosmetics according to a second embodiment of the present invention, which is suitable for use in a kit according to one embodiment of the present invention.

[0037] [Fig.4] [Fig.4] is an explanatory diagram of a schematic configuration of a A tool for penetrating anti-hair loss cosmetics according to a third embodiment of the present invention, which is suitable for use in a kit according to an embodiment of the present invention.

[0038] [Fig.5] [Fig.5] is an explanatory diagram of a schematic configuration of a A tool for penetrating anti-hair loss cosmetics according to a fourth embodiment of the present invention, which is suitable for use in a kit according to an embodiment of the present invention. Best mode for carrying out the invention

[0039] Hereinafter, a preferred embodiment of the present invention will be described.

[0040] (Kit)

[0041] The kit according to one embodiment of the present invention is a kit for personal use.

[0042] The kit is a kit in which the tool according to one embodiment of the present invention and the anti-hair loss cosmetics according to one embodiment of the present invention are combined.

[0043] It is possible to improve the penetration of the cosmetic grade anti-hair loss agent into the skin such as the scalp by superficially restructuring the skin such as the scalp using the kit according to one embodiment of the present invention.

[0044] The tool for the penetration of anti-hair loss cosmetics is a tool for personal use. The tool for the penetration of anti-hair loss cosmetics is intended to perform a micromassage of the skin such as the scalp.

[0045] As a micromassage of the skin, the tool for the penetration of anti-hair loss cosmetics can mechanically perform a superficial restructuring of the skin, such as the scalp, from the surface of the skin to a depth of up to 50 microns.

[0046] Skin, such as the scalp, to which a cosmetic-grade anti-hair loss agent has been applied may be micromassaged using the tool. This further enhances the penetration of the cosmetic-grade anti-hair loss agents into the skin, such as the scalp.

[0047] Anti-hair loss cosmetics are liquid cosmetics. Anti-hair loss cosmetics include one or more cosmetic-grade anti-hair loss agents. The one or more cosmetic-grade anti-hair loss agents include at least 2,4-diaminopyrimidine 3-N-oxide or its derivatives.

[0048] (Cosmetic process)

[0049] The beauty process according to one embodiment of the present invention may be performed using the kit according to one embodiment of the present invention. The beauty cosmetic process according to one embodiment of the present invention may include the following steps 1 to 3.

[0050] Step 1 (Skin preparation): micromassage of the skin such as the scalp using a tool for the penetration of anti-hair loss cosmetics.

[0051] Step 2 (Application of anti-hair loss cosmetics): application of anti-hair loss cosmetics to the skin such as the scalp.

[0052] Step 3 (Penetration of anti-hair loss cosmetics): micromassage of the skin such as the scalp using a tool.

[0053] In step 1 (skin preparation), a superficial restructuring of the skin such as the scalp can be carried out. In step 3 (penetration of anti-hair loss cosmetics), a micromassage which can improve the penetration of the anti-hair loss agent into the skin can be carried out.

[0054] Step 1 (skin preparation) and step 2 (application of anti-hair loss cosmetics) can be carried out at the same time. Step 2 (application of anti-hair loss cosmetics) can also be carried out after step 1 (skin preparation).

[0055] Step 1 (skin preparation) and step 2 (application of anti-hair loss cosmetics) can be carried out using the same tool for the penetration of anti-hair loss cosmetics. Step 2 (application of anti-hair loss cosmetics) can also be carried out using tools that are different from the tool for the penetration of anti-hair loss cosmetics used in step 1 (skin preparation).

[0056] Step 3 (penetration of anti-hair loss cosmetics) can also be carried out using the tool for penetration of anti-hair loss cosmetics used in step 1 (skin preparation). Step 3 (penetration of anti-hair loss cosmetics) can also be carried out using tools other than the tool for penetration of anti-hair loss cosmetics used in step 1 (skin preparation).

[0057] It is possible to easily improve the penetration of the cosmetic-grade hair loss prevention agent into the skin such as the scalp by carrying out the beauty process according to one embodiment of the present invention using the kit according to one embodiment of the present invention.

[0058] (Tool for the penetration of anti-hair loss cosmetics)

[0059] The tool for the penetration of anti-hair loss cosmetics comprises a handle, a support and a microstructured network.

[0060] The handle may be a body or housing of the tool for penetrating anti-fall cosmetics. The handle may be an elongated handle. More specifically, the elongated handle may be a rod-shaped member having a thickness sufficient for a user to hold the elongated handle with one hand. The surface of the handle may be provided with a texture or non-slip material.

[0061] The support is configured to be provided on the handle. The support has a first surface to which the handle is connected, and a second surface opposite the first surface.

[0062] The support may be secured to the handle such that the support cannot move relative to the handle. For example, the handle and the support may be a single integral member formed as a single piece.

[0063] Alternatively, the support may be provided on the handle such that the support is rotatable relative to the handle. Alternatively, the support may be provided on the handle such that it is linearly movable relative to the handle.

[0064] The network is a network placed on the support. The network is placed on the second surface of the support. The network may be formed on the entire second surface of the support. Alternatively, the network may be partially formed on the second surface of the support. The network is configured to micromassage the skin.

[0065] One end of the array is supported by a backing. The array may be bonded to the backing. Alternatively, the array may be formed integrally with the backing. The other end of the array has an abrasive surface. The abrasive surface is configured to be capable of performing controlled exfoliation, particularly of desquamated skin. More specifically, the abrasive surface is configured to be capable of mechanically scraping the skin from the skin surface to a depth of up to 50 microns. More specifically, the abrasive surface has a microstructure such as a micro / nano-structure. The microstructure may be formed, for example, by a process of treating the surface texture so as to be irregular, or may be formed by the adhesion of fine granular organs to the surface.

[0066] In the tool, it is preferable that the grating is applied to the skin surface, and that the grating is moved linearly in a direction perpendicular to the skin surface. It is more preferably that the tool applies a grating to the skin surface by linearly moving the grating back and forth in a direction perpendicular to the skin surface, i.e., by repeatedly tapping / vibrating. Furthermore, the tool may be rotated instead of the aforementioned linear movement or in combination with the aforementioned linear movement.

[0067] The tool may also manually move a grating relative to the skin surface in the linear motion and / or rotational motion described above. Alternatively, it is more preferred that the tool may automatically drive the grating relative to the skin surface in the aforementioned linear motion and / or rotational motion.

[0068] In order to automatically drive the tool, the tool may be provided with a drive mechanism described later. The drive mechanism may be provided outside the tool (handle, etc.). Alternatively, the drive mechanism is preferably provided in the hollow portion of the tool (handle or the like). The drive mechanism may include a battery, a motor driven by electricity from the battery, and a power transmission mechanism that is configured to transmit the driving force from the motor to the network.

[0069] In order to automatically apply the anti-hair loss cosmetics to the skin, the tool for penetrating anti-hair loss cosmetics may be provided with a feeding mechanism such as a reservoir described later. The feeding mechanism may be provided outside the tool for penetrating anti-hair loss cosmetics (handle, etc.). Alternatively, it is more preferred that the feeding mechanism is provided in the hollow portion of the tool for penetrating anti-hair loss cosmetics (handle or the like).

[0070] < Abrasive surface >

[0071] The abrasive surface may be an abrasive surface which is capable of performing controlled exfoliation on the skin, or more specifically can penetrate maximally into the stratum corneum and the superficial epidermis or more specifically can exfoliate the skin up to a maximum depth of 50 microns. The abrasive surface has a microstructure such as a nano-microstructure. As the abrasive surface, a silicone-based microchip having a microstructure with a protrusion height of 80 to 150 microns may be used.

[0072] Further, the abrasive surface may be made of any material such as fiber, plastic, composite, metal, or a mixture thereof. The surface Abrasive can be formed either by coating abrasive particles such as alumina on the surface, by using a diamond-tipped rod, or by forming sharp microstructures on a metal or polymer foil.

[0073] Polished particles and diamond chips may also be used on the abrasive surface. The abrasive particles and diamond chips, which are used as the abrasive surface of the microdermablation tool, may also be used as the abrasive surface.

[0074] The abrasive surfaces of the invention may be, but are not limited to, the abrasive surfaces used in the Panasonic Proderm personal PMD device or the Microderm GLO Mini diamond microdermabrasion device, or the Neutrogena microdermabrasion sheet.

[0075] A polymer or metal foil microstructure may be formed on the abrasive surface. The abrasive surface may be obtained by micro-molding, etching or 3D printing techniques. The microstructures which may be used in PLA-based microneedles from Microbase (Taiwan), silicone chip-based microneedles from Nanomed (China), hyaluronic acid-based microneedles from Raphas, (Korea) may be formed as the microstructures of the present invention.

[0076] The number of microstructures may be a single microstructure or may be in the form of an array of microstructures of size N x M. M and N may be any absolute numbers. The distance between two microstructures may be from 200 to 800 microns but more preferably is from 400 to 600 microns.

[0077] The planar shape of the abrasive surface may be, but is not limited to, a square, a rectangle, or a circle. Preferably, the shape of the microstructures is a cone or a needle shape.

[0078] Microstructures such as pointed bodies may have a width of 10 to 500 microns, preferably 10 to 300 microns, and more preferably 10 to 100 microns.

[0079] These microstructures may be made of materials from the groups of silicone, glass, metal, photosensitive resin, ceramic, biodegradable plastics and cellulose derivatives. The materials of the microstructures must not dissolve in a body fluid, preferably monocrystalline silicon, stainless steel, polyethylene or any other material that can be implanted in the skin and / or in the body. The microneedles are preferably sterile or sterilized before use and are preferably for single use.

[0080] (Application)

[0081] The choice of tool material and application method (roller or pad type) depends on the target area (hair density of the target area and surrounding area), skin sensitivity, etc.

[0082] However, in a preferred embodiment of the present invention, due to the ease of application of the tool in the presence of hairs, a hard abrasive surface pad type tool with pointed microstructures is a preferable option.

[0083] The application time of the tool of the present invention can vary from 3 seconds / cm2 to 5 minutes / cm2 but more preferably from 30 to 60 seconds / cm2 of surface.

[0084] (Anti-hair loss cosmetics)

[0085] The anti-hair loss cosmetics preferably used in the kit according to one embodiment of the present invention include one or more cosmetic-grade anti-hair loss agents.

[0086] More specifically, the one or more cosmetic grade anti-hair loss agents include 2,4-diaminopyrimidine 3-N-oxide or its derivatives. More specifically, 2,4-diaminopyrimidine 3-N-oxide and / or one of its salts and / or one of its hydrates.

[0087] The anti-hair loss agents according to one embodiment of the present invention may advantageously be chosen from the following compounds: 2,4-diaminopyrimidine 3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates and pyridinic dicarboxylic acid esters and / or their salts, as well as their mixtures. In particular, to suppress hair loss, pyridine dicarboxylic acid esters and / or their salts may be chosen.

[0088] 2,4-Diaminopyrimidine 3-N-oxide (or aminexil or DIAMINOPYRIMIDINE OXIDE) has the following chemical formula (I):

[0089] O“ U ,hk ,NH. ' He

[0090] (I)

[0091] Among the salts of organic or mineral acids which may be used, mention may be made in particular of hydrochlorides, sulfates, citrates and acetates. As hydrates, mention may be made in particular of monohydrates. Preferably, the unsalted product is used in the form of a monohydrate.

[0092] By salts of the compounds of formula (I) is meant, according to the invention, the organic or mineral salts of a compound of formula (I), these salts being physiologically acceptable. As mineral salts, mention may be made of sodium or potassium as well as zinc (Zn2+), calcium (Ca2+), copper (Cu2+), iron (Fe2+), strontium (Sr2+), magnesium (Mg2+), manganese (Mn2+); hydroxides, carbonates and chlorides. Examples of organic salts include triethanolamine, monoethanolamine, diethanolamine, hexadecylamine, N, N, N', N'-tetrakis-(hydroxy-propyl-2)ethylenediamine and tris-hydroxymethylaminomethane salts.

[0093] Preferably, the cosmetic composition according to the present invention comprises one or more anti-hair loss agents in an amount ranging from 0.001 to 20% by weight, preferably from 0.01 to 15% by weight, in particular from 0.1 to 10% by weight, even better from 0.5 to 9% by weight, or even from 1 to 8% by weight, relative to the total weight of the cosmetic composition.

[0094] (Formulation)

[0095] The specific formulations of anti-hair loss cosmetics including the anti-hair loss agent (2,4-diaminopyrimidine 3-N-oxide) according to one embodiment of the present invention are shown below.

[0096] < Formulation 1 > INCI (US / EU) Concentration % DIAMINOPYRIMIDINE OXIDE 1.50 WATER / AQUA 56.50 ACRYLATES / BEHENETH-25 METHAC RYLATE COPOLYMER 2 ALCOHOL DENAT. 40 AMINOMETHYL PROPANOL Qs pH 7.8

[0097] <Formulation 2 > INCI (US / EU) Concentration % WATER / AQUA 68.44 DIAMINOPYRIMIDINE OXIDE 1.50 CARBOMER 0.06 ALCOHOL DENAT. 30 SODIUM HYDROXIDE Qs pH 7.8

[0098] < Formulation 3 > INCI (US / EU) Concentration % WATER / AQUA 58.44 DIAMINOPYRIMIDINE OXIDE 1.50 CARBOMER 0.06 ALCOHOL DENAT. 40 SODIUM HYDROXIDE Qs pH 7.8

[0099] Example of a composition comprising at least one anti-hair loss agent: 2,4-diaminopyrimidine 3-N-oxide and softening agents (octopirox, tween 21, lecithin, panthenol) between 0.01 and 5%.

[0100] < Formulation 4 > INCI (US / EU) % Concentration WATER / AQUA 58.19 DIAMINOPYRIMIDINE OXIDE 1.50 CARBOMER 0.06 ALCOHOL DENAT. 40 PIROCTONE OLAMINE 0.25 SODIUM HYDROXIDE Qs pH 7.8

[0101] < Formulation 5 > INCI (US / EU) % Concentration WATER / AQUA 67.94 DIAMINOPYRIMIDINE OXIDE 1.50 CARBOMER 0.06 ALCOHOL DENAT. 30 LECITHIN 0.5 SODIUM HYDROXIDE Qs pH 7.8 (Assessment of the restructuring effect)

[0102] The effects of superficial restructuring of the skin by the tool according to a first embodiment described later and shown in [Fig.2] of the present invention were observed using the tool with SEM imaging.

[0103] < Evaluation method >

[0104] Human skin from the same donor was prepared and divided into two groups with an area of 2 x 2 cm for each group.

[0105] In the treatment group, the skin sample was treated with the tool according to the first embodiment ([Fig.2]) according to the present invention for 3 minutes in a circular motion.

[0106] The specifications of the tool used for the treatment group are as follows.

[0107] * Abrasive surface type: a silicone-based abrasive surface connected to a 5,000 rpm oscillating motor.

[0108] Other specifications of the tool used for the treatment group are as follows.

[0109] • Abrasive surface size: 3 x 3 mm

[0110] • Height of microstructures: 80 microns

[0111] • Base diameter of microstructures: 35 microns

[0112] * Distance between two microstructures: 450 microns

[0113] • Application: Move the tool in a circular motion along a line of from the outside to the inside to sweep the entire area.

[0114] * Speed: 10 seconds for scanning the entire area, 18 scans for a total of about 3 minutes.

[0115] • Application force: gentle pressure of approximately 10 N.

[0116] In the control group, the skin was prepared without any treatment. An area of 0.5x0.5 cm for each treated skin was then cut out and fixed on the stage with adhesive tape. After sample preparation, the stage was fixed to the sample moving stage in the sample chamber, and then the chamber was automatically evacuated. SEM imaging observation was performed under an accelerating voltage of 1 kV with a magnification of 3000x.

[0117] [Fig. 1] shows the comparison results of the SEM images of the skin. The comparison results show an SEM image of the skin of the reference group on which the tool according to the first embodiment illustrated in [Fig. 2] of the present invention described later was not applied, and the skin of the treatment group on which the tool according to the first embodiment illustrated in [Fig. 2] of the present invention described later was applied.

[0118] < Results >

[0119] As shown in [Fig.l], compared with the skin of a control group (Fig. 1A), the skin of the treatment group (Fig. 1B) shows more network patterns on the skin morphology according to the passage of the microstructures on the skin. [Fig.l] indicates the successful and effective restructuring effect on the skin by the tool of the first embodiment illustrated in [Fig.2] of the present invention.

[0120] As described above, satisfactory surface restructuring of the skin can be achieved using the tool according to the first embodiment illustrated in [Fig.2] of the present invention, which will be described later. Therefore, it It is also possible to improve the penetration into the skin of the cosmetic-grade anti-hair loss agent which will be applied in step 2 (application of anti-hair loss cosmetics) of the beauty process according to the embodiment of the present invention.

[0121] (Evaluation of the penetration effect of the anti-hair loss agent into the skin)

[0122] Next, the penetration of the anti-hair loss agent into the skin by the cosmetic process according to one embodiment of the present invention was evaluated by MALDI imaging.

[0123] < Evaluation method >

[0124] Two pig inner ear skin sample donors were used, and for each donor two samples were generated. One sample for each condition treatment. The skin was placed on a 3D3 cell filled with PBS buffer. The skin was equilibrated for one hour before measuring skin temperature (32 ± 1 °C) and skin integrity (TEWL, vapometer).

[0125] < Condition >

[0126] Condition 1: The above-mentioned formulation 1, which is a cosmetic according to the embodiment of the present invention described later, was applied topically.

[0127] Condition 2: The skin was first treated with the tool according to the first embodiment illustrated in [Fig.2] of the present invention, then formulation 1 was applied to the skin.

[0128] For condition 2, the skin was disassembled from the 3D3 cell and placed on a Kim wipe. The tool according to the first embodiment illustrated in [Fig.2] of the present invention was applied to the skin for 60 seconds with a circular motion. The skin was then replaced on a 3D3 cell before application of the composition as for condition 1. Then, for both conditions, formulation 1 containing 1.5% DIAMINOPYRIMIDINE OXIDE was applied to the skin at 10 mg / cm2. The receptor liquid was partially replaced with fresh receptor liquid (300 μl every hour) for 16 hours using a Hamilton robotic platform. After 16 hours, the skin surface was washed with a cotton swab soaked in isopropanol / water (20 / 80 v / v) and a gentle massage was performed for 30 seconds.After that, the skin samples were frozen and six images for each condition (two skin samples with three sections per sample) were analyzed by MALDI imaging at a spatial resolution of 50 pm using a CASI (Continuous Accumulation of Selected Ion) acquisition method in positive ion mode. The DIAMINOPYRIMIDINE OXIDE of the total skin of each donor for each condition was quantified and expressed as pg / g of tissue.

[0129] <Résultats>

[0130]

[0131]

[0132]

[0133]

[0134]

[0135]

[0136]

[0137]

[0138]

[0139]

[0140]

[0141]

[0142] Table 1 shows the quantification of total skin DIAMINOPYRIMIDINE OXIDE for each condition. Total skin (mean ±SD, n=6 (two donors, six sections)) Donor Donor 1 Donor 2 Condition 1 23.9 ±3.9 21.6 ±6.3 Condition 2 88.4 ±8.4 49.9 ±2.7 Quantification of DIAMINOPYRIMIDINE OXIDE by MALDI (qg / g tissue) As shown in Table 1, Condition 2 in which the skin was first treated with the tool according to the first embodiment illustrated in [Fig.2] of the invention and then Formulation 1 described in paragraph

[0101] was applied, dramatically shows an increase in active absorption by the skin (diaminopyrimidine oxide) compared to Condition 1 in which only Formulation 1 described in paragraph

[0101] was applied to the skin. From Table 1, it can be understood that the personal use kit 10 can be used to improve the penetration of diaminopyrimidine oxide (aminexil). In particular, it can improve the penetration of diaminopyrimidine oxide into the skin, especially into the hair follicles of the scalp, which can have a faster and greater effect on hair loss. From this result, it can be understood that the kit according to the embodiment of the present invention can be used to improve the penetration into the skin, such as the scalp, of a cosmetic-grade anti-hair loss agent according to an embodiment of the present invention. (Tool for the penetration of anti-hair loss cosmetics) Hereinafter, a tool for penetrating anti-hair loss cosmetics suitable for use in the kit according to one embodiment of the present invention will be described more specifically. (First embodiment) [Fig.2] shows a schematic configuration of a tool for penetrating anti-hair loss cosmetics according to the first embodiment of the present invention. The tool 10 for penetrating anti-hair loss cosmetics shown in [Fig.2] is a pad-type anti-hair loss cosmetics penetrating tool. The tool 10 comprises a handle 12, a holder 14, and a network 16. In the present embodiment, the handle 12 is an elongated handle. The support 14 is provided at one end of the elongated handle 12. More specifically, one end of the support 14 is provided at one end of the elongated handle 12. The support 14 is attached to the elongated handle 12 such that the support 14 cannot move relative to the elongated handle 12.

[0143] The network 16 is placed on the support 14. More specifically, the network 16 is placed on the other end of the support 14. The network 16 is fixed to the support 14 such that the network 16 cannot move relative to the support 14.

[0144] The network 16 comprises an abrasive surface 18. In the present embodiment, the size of the abrasive surface 18 may be 3 x 3 mm. The abrasive surface 18 has a microstructure (fine structure) 20 such as a micro / nano-structure. More specifically, the abrasive surface 18 has a plurality of microstructures 20. The height of the microstructure 20, which has a pointed shape such as an inverted cone, may be 80 microns. The diameter of the tip of the microstructure 20 may be 15 microns. The number of microstructures 20 may be 81.

[0145] The network 16 of the tool 10 is manually applied to the surface of the skin 22.

[0146] More precisely, in the tool 10, the handle 12 is held by the user's hand.

[0147] In the tool 10, the network 16 is applied to the surface of the skin 22 so as to that the abrasive surface 18 is parallel to the surface of the skin 22 such as the scalp.

[0148] The user can linearly and manually move the tool 10 in a direction perpendicular to the surface of the skin 22 (direction perpendicular to the abrasive surface 18 of the network 16).

[0149] Accordingly, the network 16 can be moved linearly in a direction perpendicular to the surface of the skin 22.

[0150] Accordingly, the surface of the skin 22 can be tapped with the network 16 comprising the microstructures 20. This makes it possible to abrade the surface of the skin 22, such as the scalp, to a depth of 50 microns.

[0151] Furthermore, the surface of the skin 22, such as the scalp, on which the anti-hair loss cosmetics according to one embodiment of the present invention have been applied, can be manually tapped using the tool 10 of the present embodiment. Thus, the surface of the skin 22 on which the anti-hair loss cosmetics according to one embodiment of the present invention have been applied can be micro-massaged using the tool 10 of the present embodiment. Accordingly, the penetration of the cosmetic-grade anti-hair loss agents according to the present embodiment into the skin 22 can be further improved.

[0152] (Second embodiment)

[0153] In the first embodiment, an example in which the tool is manually applied to the skin surface has been described. However, it is also preferable to automatically apply the tool to the skin surface.

[0154] [Fig.3] shows a schematic configuration of a tool according to the second embodiment of the present invention.

[0155] In [Fig. 3], reference numeral 100 has been added to the portion corresponding to [Fig. 2], and a description thereof will be omitted.

[0156] The tool 110 which is illustrated in [Fig.2] is configured so that the holder 114 can be moved in a linear reciprocating motion relative to the elongated handle 112.

[0157] For this purpose, the tool 110 is provided with a drive mechanism. The drive mechanism is provided on the elongated handle 112. More specifically, the elongated handle 112 has a hollow portion 124. A drive mechanism is provided in the hollow portion 124 of the elongated handle 112.

[0158] The drive mechanism includes a power supply 126, a motor 128, and a shaft 130.

[0159] The drive mechanism is configured so that the grating 116 placed on the support 114 can be driven in a linear reciprocating motion relative to the elongated handle 112 in a direction perpendicular to the abrasive surface 118 of the grating 116. For this purpose, the drive mechanism is connected to the support 114. More specifically, the power supply 126 and the motor 128 are connected to the support 114 via the shaft 130.

[0160] Thus, the support 114 can be driven in a linear reciprocating motion relative to the elongated handle 112 in a direction perpendicular to the abrasive surface 118 of the network 116 by the drive mechanism.

[0161] Therefore, the network 116 can be linearly moved back and forth in a direction perpendicular to the surface of the skin 122, such as the scalp.

[0162] Accordingly, the surface of the skin 122 such as the scalp can be repeatedly tapped from the vertical direction of the skin 122 using the array 116.

[0163] As described above, according to the present embodiment, since the tool 110 further comprises the drive mechanism, a more efficient tapping / vibrating operation by the array 116 of the tool 110 can be provided.

[0164] The frequency of tapping the skin by the network 116 may be 10 to 1,000 times / minute, preferably 1,000 to 8,000 times / minute, and more preferably 3,000 to 6,000 times / minute. This also makes it possible to obtain a continuous and stable skin puncture.

[0165] Therefore, the force required by the user to move the network 116 toward the skin 122 can be reduced. The skin 122 can be abraded more easily to a depth of 50 microns.

[0166] The anti-hair loss cosmetics according to an embodiment of the present invention can be easily applied to the skin surface 122 such as the scalp by automatically tapping the skin surface 122 such as the scalp by the tool 110 of the present embodiment.

[0167] The skin 122 on which the anti-hair loss cosmetics according to one embodiment of the present invention have been applied can be automatically massaged using the tool 110. Therefore, the penetration of anti-hair loss cosmetics according to one embodiment of the present invention into the skin 122 can be further improved.

[0168] In the present embodiment, the motor 128 may be a 5,000 rpm vibration motor. The abrasive surface 118 may be a silicone-based abrasive surface that is connected to a motor 128 such as a 5,000 rpm vibration motor.

[0169] The tool 110 may be in the form of a pen, a stamp or a gun.

[0170] In the present invention, the tool 110 may include an oscillator that vibrates the network 116 in a direction perpendicular to the abrasive surface 118 of the network 116. The oscillator may also be a piezoelectric crystal independent or integrated into the actuator, or a combination thereof.

[0171] (Third embodiment)

[0172] In the first embodiment and the second embodiment, an example in which the tool of the present invention does not include the anti-hair loss cosmetics has been described. However, it is also preferable that the tool of the present invention contains the anti-hair loss cosmetics.

[0173] Accordingly, step 1 (skin preparation) and step 2 (application of anti-hair loss cosmetics) of the cosmetic process according to an embodiment of the present invention can be carried out simultaneously using a tool such as the tool of the present embodiment.

[0174] [Fig.4] shows a schematic configuration of a kit according to one embodiment of the present invention. The kit comprises the tool according to the third embodiment of the present invention, and anti-hair loss cosmetics according to one embodiment of the present invention.

[0175] In [Fig.4], reference numeral 200 has been added to the portion corresponding to [Fig.2], and a description thereof will be omitted.

[0176] In the present embodiment, the handle 212 comprises a hollow portion 224.

[0177] The hollow portion 224 of the handle 212 is configured to receive the anti-hair loss cosmetics 232. More specifically, the hollow portion 224 of the handle 212 is provided with a reservoir 214 as a holder of the present invention. The reservoir 214 contains the anti-hair loss cosmetics 232 according to an embodiment of the present invention.

[0178] The network 216 is placed on one end of the tank 214.

[0179] In the tool of the present embodiment, the reservoir 214 is configured such that the reservoir 214 can be moved linearly relative to the handle 212 in a direction perpendicular to the abrasive surface 218 of the array 216. Accordingly, the array 216 is configured to be capable of linear movement in the direction perpendicular to the skin surface 222.

[0180] The anti-hair loss cosmetics 232 contained in the reservoir 214 are provided to be fluidly connected to the network 216. More specifically, the abrasive surface 218 of the network 216 comprises one or more openings 234. The one or more openings 234 are configured to be fluidly connected to the anti-hair loss cosmetics 232 contained in the reservoir 214. The anti-hair loss cosmetics 232 contained in the reservoir 214 can be applied to the skin surface 222 through the opening 234 of the network 216.

[0181] The tool 210 of the present embodiment can be manually moved rectilinearly such that the reservoir 214 can be moved rectilinearly relative to the handle 212 in a direction perpendicular to the abrasive surface 218 of the array 216.

[0182] Thus, step 1 (skin preparation) of the beauty process according to an embodiment of the present invention can be carried out using the tool 210 of the present embodiment.

[0183] The tool 210 of the present embodiment can rectilinearly move the reservoir 214 manually relative to the handle 212 in a direction perpendicular to the abrasive surface 218 of the array 216 so that the hair loss prevention cosmetics 232 contained in the reservoir 214 can naturally fall from the opening 234 of the array 216, and the hair loss prevention cosmetics 232 can be applied to the skin surface 222. Therefore, step 2 (application of hair loss prevention cosmetics) of the beauty process according to an embodiment of the present invention can be performed using the tool 210 of the present embodiment.

[0184] Step 1 (skin preparation) and step 2 (application of anti-hair loss cosmetics) of the beauty process according to an embodiment of the present invention can be performed simultaneously using the tool 210 of the present embodiment.

[0185] Step 1 (scalp preparation) of the beauty process according to one embodiment of the present invention can be performed, and then step 2 (application of anti-hair loss cosmetics) can be performed using tool 210 of the present embodiment.

[0186] (Fourth embodiment)

[0187] In [Fig.5], an example in which the network placed on the tank as a support of the present invention is manually moved in a rectilinear manner has been described. However, it is also preferable that the network placed on the tank can be moved in a straight line automatically.

[0188] Therefore, step 1 (skin preparation) and step 2 (application of anti-hair loss cosmetics) of the beauty process according to one embodiment of the present invention can be carried out more easily.

[0189] [Fig.5] shows a schematic configuration of a kit according to one embodiment of the present invention. The kit comprises the tool according to the fourth embodiment of the present invention and the anti-hair loss cosmetics according to one embodiment of the present invention.

[0190] In [Fig.5], the reference number 100 has been added to the portion corresponding to the [Fig.4], and a description thereof will be omitted. In [Fig.5], reference number 200 has been added to the portion corresponding to [Fig.3], and a description thereof will be omitted.

[0191] In the present embodiment, a drive mechanism is provided in the hollow portion 324 of the handle 312.

[0192] A reservoir 314 is also provided in the hollow portion 324 of the handle 312.

[0193] The drive mechanism is connected to the reservoir 314. More specifically, a end of the shaft 330 of the drive mechanism is connected to one end of the reservoir 314. The network 316 is placed on the other end of the reservoir 314.

[0194] The drive mechanism linearly and automatically reciprocates the grating 316 placed on the reservoir 314 as a support of the present invention relative to the handle 312 in a direction perpendicular to the abrasive surface 318 of the grating 316.

[0195] In the present embodiment, a housing 336 may further be provided outside of the handle 312 and the reservoir 314.

[0196] In the present embodiment, the grating 316 placed on the reservoir 314 as a support of the present invention can be linearly and automatically moved. More specifically, the drive mechanism can linearly and automatically move the reservoir 314 relative to the handle 312 in a direction perpendicular to the abrasive surface 318 of the grating 316. Accordingly, the grating 316 placed on the reservoir 314 can be linearly and automatically reciprocated in a direction perpendicular to the abrasive surface 318 of the grating 316. This allows for linear and automatic reciprocating movement of the grating 316 in a direction perpendicular to the skin surface 322.

[0197] Thus, the anti-hair loss cosmetics 332 contained in the reservoir 314 can automatically fall from the opening 334 of the network 316, and the anti-hair loss cosmetics 332 are applied to the surface of the skin 322. Therefore, step 2 (application of anti-hair loss cosmetics) of the beauty process according to an embodiment of the present invention can be carried out more easily by using the tool 310 of the present embodiment.

[0198] Step 1 (skin preparation) and step 2 (application of anti-hair loss cosmetics) of the beauty process according to an embodiment of the present invention can be more easily performed at the same time by using the tool 310 of the present embodiment.

[0199] Step 2 (application of anti-hair loss cosmetics) performed after step 1 (skin preparation) of the beauty process according to an embodiment of the present invention can also be performed more easily using the tool 310 of the present embodiment.

[0200] (Controller)

[0201] In order to automatically execute step 1, step 2 and step 3 of the beauty process according to the embodiment of the present invention, it is also preferable that the drive mechanism includes a controller. The controller may be provided between the power supply and the motor of the drive mechanism. The controller may control the operation of the drive mechanism to automatically execute step 1 (skin preparation). For example, the operation of the drive mechanism (e.g., the stroke width of the reciprocating motion, the speed and time, etc.) is controlled so that the skin to be abraded by the array has a depth of up to 50 microns.

[0202] The tool of the present invention may include a feed mechanism for automatically applying a desired amount of hair loss prevention cosmetics from the tool to the skin at a desired time. The controller controls the operation of the feed mechanism and / or the operation of the drive mechanism so as to automatically perform step 2 (application of hair loss prevention cosmetics). Thus, the tool of the present invention may automatically apply a desired amount of hair loss prevention cosmetics to the skin from the tool at a desired time.

[0203] (Technical effects)

[0204] As described above, according to the kit of the present invention, the tool for penetration of anti-hair loss cosmetics according to the present invention and the anti-hair loss cosmetics according to the present invention have been combined. Thus, it is possible to easily mechanically restructure the surface of the skin such as the scalp by using the personal use tool of the present invention. It is also possible to easily apply a cosmetic-grade anti-hair loss agent (2,4-diaminopyrimidine 3-N-oxide or a derivative thereof). This allows individuals to more easily and effectively improve the penetration of cosmetic-grade anti-hair loss agents (2,4-diaminopyrimidine 3-N-oxide or its derivatives) into the skin.

[0205] Various embodiments of the present invention have been explained above with reference to the drawings. However, the present invention is not limited to these embodiments, and various modifications and changes may be made to the embodiments described above without departing from the essence and scope of the present invention, and these modifications and changes are included within the scope of the present invention.

Claims

Claims

1. A tool for penetrating anti-hair loss cosmetics, the tool comprising: - a handle, - a holder configured to connect to the handle, and - a microstructured network placed on the holder, the microstructured network being configured to abrade the skin, wherein the microstructure of the network has a pointed shape, and the microstructure is a plurality of microstructures, the distance between two adjacent microstructures is from 200 to 800 microns, wherein the handle is provided with a drive mechanism, the drive mechanism is connected to the holder, and the drive mechanism is configured to reciprocate the network placed on the holder relative to the handle in a direction perpendicular to the network.

2. The tool of claim 1, wherein the handle has a hollow portion, and the drive mechanism is provided in the hollow portion of the handle.

3. A tool according to any one of claims 1 to 2, wherein the height of the network microstructure is 50 to 500 microns.

4. A tool according to any one of claims 1 to 3, wherein the microstructure is configured to abrade the skin from the surface of the skin to a depth of up to 50 microns.

5. A tool according to any one of claims 1 to 4, wherein the network is configured to fluidly connect to the anti-hair loss cosmetics so as to be able to apply the anti-hair loss cosmetics from the network to the skin.

6. The tool of claim 5, wherein the handle has a hollow reservoir portion for holding the anti-hair loss cosmetics.

7. Kit comprising a tool according to any one of claims 1 to 6 and anti-hair loss cosmetics, anti-hair loss cosmetics including one or more anti-hair loss agents, and the one or more anti-hair loss agents include at least 2,4-diaminopyrimidine 3-N-oxide or a derivative thereof.

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