A system and protocol based on oxidants and acids to enhance the appearance of the skin

Abstract

OXIDANT AND ACID BASED SYSTEM AND PROTOCOL FOR ENHANCING SKIN APPEARANCE A cosmetic skin enhancement system gives the skin an improved appearance, including enhanced facial skin radiance, reduced pore appearance, improved visual smoothness, and a reduction in the appearance of fine lines and wrinkles.The cosmetic skin enhancement system comprises a skin application protocol and a manufacturing article for using the cosmetic skin enhancement system, comprising at least two separately contained first and second compositions, each comprising an oxidizing component comprising at least one oxidizing agent and water, and a chemical peeling component comprising at least one hydroxy acid and water, each contained for separate dispensing for application to the skin in any order. The skin enhancement system may be used according to any one of several possible application protocols in which the oxidizing component is used in conjunction with the chemical peeling component, applied sequentially, either once or, more frequently, with applications of at least one of the components on a daily basis for a few days or several days. Figure for the abstract: none.

Description

Title of the invention: Oxidant- and acid-based system and protocol for enhancing the appearance of the skin. Field of the invention

[0001] The present invention generally relates to a cosmetic system for improving the appearance of the skin, including enhancing the skin's visual radiance and smoothness, reducing the appearance of pores, and reducing the appearance of fine lines and wrinkles, and a complexion-enhancing protocol and a manufactured article for using the complexion-enhancing cosmetic system. The complexion-enhancing system is particularly suitable for application to the skin anywhere on the body, especially on the face, in certain specific embodiments, generally avoiding the eye contour and under the eyes. Context of the invention

[0002] Chemical peels are non-invasive dermatological products and approaches for improving and treating skin conditions, including: sun-damaged skin, hyperpigmentation, simple acne, rosacea, precancerous skin lesions, wrinkles and fine lines, superficial scars, etc. These cosmetic compositions comprise a solution of acids which, when applied topically, penetrate the skin, inducing and accelerating a natural skin regeneration process by removing the dead outer layers of skin. The strength and effectiveness of a peel are dictated by the formulation, the type of acid, and the concentration, factors that affect the depth of penetration into the skin. Common chemical peel compositions include one or more of the following: glycolic acid, lactic acid, salicylic acid, and trichloroacetic acid (TCA), among other ingredients.The effectiveness of chemical peels depends on the concentration of hydroxylated acids (usually alpha- and beta-hydroxy acids) AHA / BHA and the pH of the formula.

[0003] Professional-type peels include high levels of acid, for example, above 30%, and an extremely low pH, generally below 3, and are usually restricted to use by licensed dermatologists and / or estheticians. The main advantage of professional-type peels is that they provide relatively rapid and significant rejuvenating effects, which may include one or more of the following: skin radiance / brightness, pore appearance, skin smoothness, and reduction of fine lines and wrinkles. However, professional-type peels can be expensive, are not as convenient as at-home use, cause relatively high irritation, and may involve downtime between treatments. Applications. At-home peels used on the domestic market generally contain alpha hydroxy acids (glycolic acid, lactic acid, mandelic acid, etc.) at a concentration of less than 10%, with a final pH above 3.0. The main advantages of at-home peels include convenience for the consumer and potential cost savings; however, it normally takes about a month to see rejuvenating results, and the results are generally less impressive than those of professional-grade peels.

[0004] There is a need for a skin enhancement system that gives exceptional and rapid results such as those seen with professional peeling compositions, with minimized or no side effects and no downtime compared to professional peeling compositions.

[0005] As described herein, the inventors have developed a skin enhancement system which includes an oxidizing component and a chemical peeling component, which skin enhancement system can significantly reduce the time required to obtain the benefits of chemical peeling compared to home peeling compositions used alone, and without the irritation that is common with professional-type peeling compositions. Summary of the invention

[0006] The summary is provided to introduce a selection of concepts in a simplified form, which are described in more detail below in the detailed description of the invention. This summary is not intended to identify the principal features of the claimed subject matter, nor to be used as an aid in determining the scope of the claimed subject matter.

[0007] In various embodiments, compositions are provided for use according to the invention which include oxidizing and chemical peeling components, provided for sequential application to the skin according to the protocols described herein.

[0008] In various embodiments, the invention relates to a manufacturing article for a skin improvement system comprising at least a first and a second composition contained separately, the first composition comprising an oxidizing component, comprising at least one oxidizing agent and water, and the second composition comprising a chemical peeling component comprising at least one hydroxy acid and water, the first and second compositions being contained for separate dispensing for application to the skin, in any order, and the skin improvement system being usable according to any one of a number of possible embodiments of the skin improvement protocol of the invention, herein referred to as application cycles, the oxidizing component being used in conjunction with the chemical peeling component, applied sequentially, each component being applied once a day, or more frequently, with applications of at least one of the components daily for a few days or several days.

[0009] In some embodiments, the oxidizing agent in the oxidizing component is chosen from the group consisting of hydrogen peroxide, urea peroxide, carbamide peroxide, PVP hydrogen peroxide and their combinations.

[0010] In some embodiments, the oxidizing agent in the oxidizing component is present at a rate of approximately 1% to approximately 10% by weight, based on the total weight of the oxidizing component.

[0011] In some embodiments, the hydroxy acid in the chemical peeling component is chosen from the group consisting of alpha-hydroxy acids, beta-hydroxy acids, poly-hydroxy acids and combinations thereof.

[0012] In some embodiments, the hydroxy acid in the chemical peeling component comprises at least one alpha-hydroxy acid present from approximately 4% to approximately 15% by weight, based on the total weight of the chemical peeling component. In one example, the at least one alpha-hydroxy acid comprises lactic acid.

[0013] In some embodiments, the hydroxy acid in the chemical peeling component further comprises at least one beta-hydroxy acid present at a concentration of approximately 0.1% to approximately 2% by weight, based on the total weight of the chemical peeling component. In one example, the at least one beta-hydroxy acid comprises salicylic acid.

[0014] In some embodiments, the hydroxy acid in the chemical peeling component further comprises at least one beta-hydroxy acid present from approximately 4% to approximately 15% by weight, based on the total weight of the chemical peeling component. In one example, the at least one polyhydroxy acid comprises gluconolactone.

[0015] In some embodiments, the chemical peeling component comprises two or more hydroxy acids selected from the group consisting of alpha-hydroxy acids, beta-hydroxy acids, poly-hydroxy acids and combinations thereof.

[0016] In certain embodiments, the oxidizing agent in the oxidizing component is selected from the group consisting of hydrogen peroxide, urea peroxide, carbamide peroxide, PVP hydrogen peroxide and combinations thereof, and is present from approximately 1% to approximately 10% by weight, based on the total weight of the oxidizing component, and the oxidizing component further comprises at least one oil, at least one chelating agent and at least one additional ingredient selected from the group consisting of water-based solvents, surfactants, thickeners, pH adjusters, humectants, antioxidants, plant extracts, vegetable oils, vegetable butters, perfumes, mother-of-pearl, odor absorbers, colorants, essential oils, vitamins, antimicrobials, preservatives and their combinations. combinations.

[0017] In some embodiments, the hydroxy acid in the chemical peeling component further comprises at least one beta-hydroxy acid present from about 0.1% to about 2% by weight, or at least one poly-hydroxy acid present from about 4% to about 15% by weight, the amounts being based on the total weight of the chemical peeling component, and the chemical peeling component further comprises at least one additional ingredient selected from the group consisting of oils, water-based solvents, surfactants, thickeners, phenylethyl resorcinol, chelating agents, pH adjusters, humectants, antioxidants, plant extracts, vegetable oils, vegetable butters, perfumes, pearlescent agents, odor absorbers, coloring materials, essential oils, vitamins, antimicrobials, preservatives and combinations thereof.

[0018] In some embodiments, each of the oxidizing component and the chemical peeling component is supplied in a form with or without rinsing and is selected from the group consisting of a suspension, an emulsion cream, a serum, an essence, a gel and a tonic.

[0019] In some embodiments, one of the oxidizing component and the chemical peeling component is a toner and the other is a cream or moisturizer (for example, a creamy emulsion). In some embodiments, both the oxidizing component and the chemical peeling component are toners. And in some embodiments, both the oxidizing component and the chemical peeling component are creams or moisturizers.

[0020] In some embodiments, the manufactured article comprises the first and second compositions, each contained separately in a single-use container.

[0021] In some embodiments, the manufactured article comprises the first and second compositions, each contained separately in a single-use container.

[0022] In some embodiments, the manufactured article comprises the first and second compositions, each contained separately as unique units in a plurality of single-use containers.

[0023] The invention also proposes, in various embodiments, a manufacturing article for the skin improvement system comprising at least first and second compositions contained separately.

[0024] In certain embodiments, the first composition comprises an oxidizing component selected from the group consisting of: at least one oxidizing agent comprising hydrogen peroxide, optionally, one or more agents selected from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and their combinations, and water, in which the oxidizing component is formulated as a tonic; and at least one oxidizing agent comprising hydrogen peroxide, optionally one or more agents selected from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and combinations thereof; one or a combination of surfactants comprising steareth-2 and steareth-20; one or more polymers comprising sclerotium gum; one or more vitamin actives, preservatives or combinations thereof and water present in an amount of about 35% to about 75%, by weight, based on the weight of the oxidizing component, the oxidizing component being formulated as a creamy emulsion.

[0025] In certain embodiments, the second composition comprises a chemical peeling component selected from the group consisting of: (i) a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid; an oil or combination of oils comprising squalane and nut oils; one or a combination of surfactants; one or more thickeners; one or more water-based solvents comprising glycerin; one or more vitamin actives, preservatives, chelating agents, pH adjusters or combinations thereof and water present in an amount of about 40% to about 50%, by weight, based on the weight of the skin peeling component, the chemical peeling component being formulated as a creamy emulsion; and (ii) a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid;an oil or a combination of vegetable oils or butters; a surfactant or combination of surfactants including betaine; one or more thickeners including carrageenan; one or more water-based solvents including glycerin or propanediol; one or more active ingredients including hyaluronic acid, perfumes, preservatives, chelating agents, pH adjusters, or combinations thereof; and water present in an amount of approximately 40% to approximately 50%, by weight, based on the weight of the skin peeling component, in which the chemical peeling component is formulated as a tonic.

[0026] In various embodiments, the first and second compositions are contained to be dispensed separately for application to the skin, in any order, and the skin enhancement system can be used according to any of a number of possible application cycles of the skin enhancement protocol, the oxidizing component being used in conjunction with the chemical peeling component, applied sequentially, once or, more frequently, with applications of at least one of the components on a daily basis for a few days or several days.

[0027] In some embodiments, each of the first and second compositions is contained in a mask, liquid, stick, spray, ointment, paste, foam, scum, shaving cream, wipe, patch, strip or film-forming product.

[0028] In some embodiments, the first composition is an oxidizing component contained for application as a rinse-off mask, and the second composition is a chemical peeling component contained for application as a leave-on cream.

[0029] The invention also proposes, in various embodiments, a protocol for improving the skin using oxidizing application components and acids, comprising applying to a skin area, excluding the skin around the eyes, (a) a first composition comprising an oxidizing component that includes an oxidizing agent and water; and (b) a second composition comprising a chemical peeling component that includes one or a combination of hydroxy acids and water, the first and second compositions being applied sequentially, in any order. In some embodiments, the oxidizing component is applied first, followed by the chemical peeling component, and in other embodiments, the chemical peeling component is applied first, followed by the oxidizing component.

[0030] In some embodiments, the steps of the protocol further include (c) rinsing the skin after application of at least one of the first and second compositions, and include (a), (b) and (c) in any order, step (c) being able to be repeated.

[0031] The protocol can be chosen from one or a combination of application cycles.

[0032] The invention also proposes, in certain embodiments, a skin-improving protocol comprising the provision of a first composition including an oxidizing composition chosen from the group consisting of: at least one oxidizing agent comprising hydrogen peroxide, optionally, one or more agents chosen from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and combinations thereof, and water, in which the oxidizing component is formulated as a tonic; and at least one oxidizing agent comprising hydrogen peroxide, optionally, one or more agents chosen from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and combinations thereof;one or a combination of surfactants including steareth-2 and steareth-20; one or more polymers including sclerotium gum; one or more vitamin actives, preservatives or combinations thereof and water present in an amount of approximately 35% to approximately; 75%, by weight, based on the weight of the oxidizing component, the oxidizing component being formulated as a creamy emulsion, a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid; an oil or combination of oils comprising squalane and nut oils; one or a combination of surfactants; one or more thickeners; one or more water-based solvents comprising glycerin; one or more vitamin actives, preservatives, chelating agents, pH adjusters or combinations thereof and water present in an amount of approximately 40% to approximately 50%, by weight, based on the weight of the skin-peel component, the chemical peeling component being formulated as a creamy emulsion; and a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid;an oil or a combination of vegetable oils or butters; a surfactant or combination of surfactants including betaine; one or more thickeners including carrageenan; one or more water-based solvents including glycerin or propanediol; one or more active ingredients including hyaluronic acid, perfumes, preservatives, chelating agents, pH adjusters, or combinations thereof; and water present in an amount of approximately 40% to approximately 50%, by weight, based on the weight of the skin peeling component, in which the chemical peeling component is formulated as a toner. The protocol further includes the application of the first composition to an area of ​​skin, excluding the skin around the eyes;the application of the first composition to an area of ​​skin excluding the skin around the eye, the first and second compositions being applied sequentially, in any order. ;

[0033] In some embodiments, the steps of the protocol further include (e) rinsing the skin after the application of at least one of the first and second compositions, and include (c), (d) and (e) in any order, and step (e) may be repeated.

[0034] In some embodiments, after a first instance of the step of applying the first composition, the step of applying the second composition is repeated once a day, over several days.

[0035] In some embodiments, the step of applying the first composition is repeated once every third, fourth or fifth day and the step of applying the second composition is skipped on the days when the step of applying the first composition is repeated.

[0036] In some embodiments, the protocol is practiced for at least 28 days.

[0037] In certain embodiments, the application of the first and second com Positions according to the protocol offer synergistic advantages in stimulating cell growth and proliferation compared to using the first and second compositions independently.

[0038] In some embodiments, the application of the first and second compositions according to the protocol results in a reduction of skin discomfort compared to the use of the first and second compositions independently.

[0039] In some embodiments, the application of the first and second compositions according to the protocol results in an increased improvement in skin radiance compared to the use of the first and second compositions independently.

[0040] Other features and advantages of the present invention will become apparent from the following more detailed description, by way of example, of the principles of the invention.

[0041] This disclosure describes exemplary embodiments in accordance with the general inventive concepts and is in no way intended to limit the scope of the invention. Indeed, the invention as described herein is broader than the exemplary embodiments presented herein and is not limited by them, and the terms used herein have their full ordinary meaning. Brief description of the drawings

[0042] This application contains at least one drawing executed in color. Copies of this patent publication or patent application with the drawing(s) in color will be provided by the Office upon request and against payment of the required fee.

[0043] The features and advantages of the general concepts of the invention will become evident from the following description made with reference to the accompanying drawings, including the drawings shown herein in the attached set of Figures, of which the following is a brief description:

[0044] [Fig.1] Fig.1 represents a histogram showing the results according to a first study;

[0045] [Fig.2] Fig.2 represents a histogram showing the results according to the first study ;

[0046] [Fig. 3] [Fig. 3] shows color photographs of the treated skin tissue showing the effect of the skin improvement protocol of the invention;

[0047] [Fig.4] Fig.4 represents the effects of the system of the invention on the reflection of the radiance of the skin;

[0048] [Fig. 5] [Fig. 5] presents the results of clinical grading of skin radiance at different times depending on the clinical study;

[0049] [Fig.6] Figure [Fig.6] presents the results of clinical grading of pore appearance at different times depending on the clinical study;

[0050] [Fig.7] [Fig.7] presents the clinical classification results of visual softness. of the skin at different times according to the clinical study;

[0051] [Fig.8] Fig.8 presents the results of the clinical evaluation of facial fine lines at different times according to the clinical study.

[0052] This invention describes exemplary embodiments in accordance with the general inventive concepts and is in no way intended to limit the scope of the invention. Indeed, the invention as described herein is broader than the exemplary embodiments presented herein and is not limited by them, and the terms used herein have their full ordinary meaning.

[0053] According to the various embodiments, any aspect of any embodiment may be combined or used with any other, unless explicitly stated to be exclusive or not included. Detailed description of the invention

[0054] As used herein, the term "skin rejuvenation" refers to the effects on the skin resulting from the use of the skin enhancement system of the invention, which may include one or more elements, including improved skin radiance, an improved or reduced pore appearance, improved visual smoothness of the skin, and a reduction of fine lines and wrinkles.

[0055] As shown here, the inventors have proposed a skin-enhancing system comprising an oxidizing component, for example, an oxidizing component containing peroxide, and a chemical peeling component, for example, a chemical peeling component containing a hydroxy acid. Use of the skin-enhancing system provides the benefits of improving radiance, minimizing the appearance of pores, enhancing the skin's visual smoothness, and reducing the appearance of fine lines and wrinkles. The skin-enhancing system is particularly suitable for application to skin anywhere on the body, especially on the face, generally avoiding the skin under and around the eyes.

[0056] The skin improvement system can be used according to any of several possible application cycles of the skin improvement protocol in which the oxidizing component is used in conjunction with the chemical peeling component, applied sequentially, once or more frequently, with applications of at least one of the components on a daily basis for a few days or several days, to significantly improve the speed and extent of skin rejuvenation compared to a chemical peel used alone at home. Any of the possible application cycles of the skin improvement protocol can be carried out using a manufactured item that includes each of the oxidizing and chemical peeling components packaged in a manner suitable for the protocol.

[0057] The oxidizing component and the chemical peeling component can each be supplied in a form that can be rinsed off or not. For example, the oxidizing component can be used as a creamy emulsion, for example as a rinse-off mask or as a leave-on moisturizer, or in a leave-on fluid toner, and the chemical peeling component can also be a rinse-off mask, or a leave-on moisturizer, or be contained in a leave-on fluid toner. In some embodiments, one of the components is to be rinsed off and the other is not. In some embodiments, both components are to be rinsed off, or both components are to be left on.

[0058] As illustrated herein, the inventors have shown in an in vitro stratum corneum (SC) model for lipid disorganization that the oxidizing component can act as a booster to enhance the effectiveness of the chemical peeling component, resulting in increased lipid disorganization in the stratum corneum model. More specifically, applying the oxidizing component followed by the chemical peeling component, compared to using the chemical peeling component alone, results in a consistently higher level of lipid disorganization in stratum corneum studies, regardless of the formulation. As shown in the examples, the effects are synergistic in that the effect on the stratum corneum of the inventive combination of the oxidizing component and the chemical peeling component is greater than the sum of the components when used alone.Furthermore, the results are consistently observed regardless of whether either component is applied as a rinse-off formulation or not.

[0059] Furthermore, the inventors have shown in a clinical study using an inventive skin-enhancing protocol that there is a faster improvement in radiance, pore appearance, visual smoothness of the skin, and overall facial fine lines and wrinkles, compared to daily use of the chemical peeling component alone. In particular, the inventors have shown that there is a detectable improvement in radiance as early as 3 days after the start of the protocol, and a detectable improvement in overall facial fine lines when the aforementioned protocol is followed for fourteen days. Moreover, the inventors have also shown that there is a greater improvement in radiance and overall facial fine lines when the aforementioned skin-enhancing protocol is followed for at least one month.The study involved a skin-improvement protocol application cycle comprising twice-weekly application of a rinse-off mask containing the oxidizing component and daily application of a leave-on moisturizing emulsion in the form of a chemical peeling component.

[0060] Whereas the data provided in the examples were obtained with the application The oxidizing component is followed by the chemical peeling component, in that order. Any application sequence is acceptable, including at least one application of each component, alternating between the oxidizing and chemical peeling components. In some specific examples, a skin improvement protocol includes applying the chemical peeling component at least twice or more, up to daily applications for a week or more, and applying the oxidizing component at least once, up to twice a week.

[0061] These unexpected benefits of skin radiance, visual smoothness, reduced pore size, and overall improvement of facial fine lines are achieved according to the present invention in a shorter period of time than is typical with conventional at-home chemical peels (e.g., the peeling moisturizer tested in the study as illustrated here), and with less irritation than that observed with professional chemical peels. Longer-term use of the skin-enhancing system of the invention, for example, for at least one month, provides further reduction of wrinkles and fine lines, also with less irritation than is observed with professional chemical peels. In some embodiments, the chemical peeling component is an at-home peeling composition.

[0062] In accordance with the various embodiments, it is envisaged that some or all of the following ingredients may be included in the compositions used according to the invention:

[0063] OXIDIZING COMPONENT OF THE SKIN IMPROVEMENT TREATMENT

[0064] In various embodiments, the oxidizing component of the skin-enhancing system comprises an oxidizing agent, for example, hydrogen peroxide. The oxidizing component of the skin-enhancing system also comprises one or more additional ingredients, including water, at least one oil, at least one chelating agent, and may further comprise one or more ingredients selected from the group consisting of one or more water-based solvents, one or more surfactants, one or more thickeners, and one or more additional ingredients selected from, in particular, pH-adjusting agents, active ingredients, humectants, antioxidants, plant extracts, vegetable oils and butters, perfumes, pearlescent agents, odor absorbers, colorants, essential oils, vitamins, antimicrobials, preservatives, and combinations thereof.

[0065] The oxidizing component may be supplied in a rinse-off or leave-on form. For example, the oxidizing component may be used as a creamy emulsion, for example as a rinse-off mask, or as a moisturizing emulsion or leave-on toner, which may be thick or liquid (fluid). Other formulations are possible, and the examples given are not limiting. More generally, the oxidizing component may be supplied as a rinse-off or rinse-off formulation and in a form selected from the group consisting of a suspension, emulsion cream, serum, essence, gel or tonic, and may be packaged in a form such as a stick, spray, ointment, paste, foam, emulsion, shaving cream, wipe, patch, strip, film-forming product, mask and combinations thereof.

[0066] In certain particular embodiments, the oxidizing component of the skin-enhancing system is a creamy emulsion form that may be thick or liquid (fluid). According to some examples of embodiments in which the oxidizing component of the skin-enhancing system is a creamy emulsion form, the composition may include an oxidizing agent comprising hydrogen peroxide, one or a combination of chelating agents including tetrasodium glutamate diacetate, tetrasodium phosphate, one or a combination of phosphoric acid and sodium phosphate, a combination of surfactants including steareth-2 and steareth-20, one or more polymers including sclerotia gum, one or more vitamin actives, one or more preservatives, and water present in an amount of approximately 35% to approximately 75% by weight, based on the weight of the oxidizing component.

[0067] In certain particular embodiments, the oxidizing component of the skin enhancement system is a form of liquid tonic.

[0068] Therefore, the various ingredients that may be present in the oxidizing component of the skin enhancement system are provided below or further here in the section described as other ingredients, and as shown in the examples herein. Oxidizing agent

[0069] In certain embodiments, the oxidizing component of the skin-enhancing system may comprise one or more of the following: hydrogen peroxide, urea peroxide, carbamide peroxide, and PVP hydrogen peroxide (a polyvinylpyrrolidone-hydrogen peroxide complex). In some particular embodiments, the oxidizing component of the skin-enhancing system comprises hydrogen peroxide.

[0070] According to the various embodiments, the amount of oxidizing agent present in the oxidizing component of the skin-enhancing system may range from about 1% to about 10%, from about 1% to about 7%, from about 1.0% to about 5%, from about 1.0% to about 4.0%, from 1.5% to about 4.5%, or about 4%, or any appropriate combination, subcombination, range, or subrange thereof by weight, based on the weight of the oxidizing component of the skin-enhancing system. Those skilled in the art, however, will appreciate that other ranges are found in the scope of the invention.

[0071] Thus, at least one oxidizing agent may be present, by weight, based on the weight of the oxidizing component of the skin enhancement system, each present from about 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, up to about 10 percent by weight, including increments and ranges within and between these. Oil

[0072] According to the invention, one or more oils are present in the oxidizing component of the skin improvement system. The oil comprises one or more non-siliconized oils of animal, vegetable, mineral or synthetic origin, silicone oils, hydrocarbon compounds, fatty alcohols, fatty acids, fatty acid and / or fatty alcohol esters, non-siliconized waxes and silicones.

[0073] In some embodiments, the oil comprises, in particular: 1) lower C6-C16 alkanes, non-siliconized oils of animal, vegetable, mineral or synthetic origin, fatty alcohols, fatty acids, non-siliconized waxes and silicones; 2) hydrocarbon oils of animal origin, such as perhydrosqualene (also called "squalene"); 3) fluorinated oils, perfluoromethylcyclopentane and perfluoro-1,3-dimethylcyclohexane, marketed under the names FLUTEC® PCI and FLUTEC® PC3 by BNFL Fluorochemicals; perfluoro-1,2-dimethylcyclobutane; perfluoroalkanes such as dodecafluoropentane and tetradecafluorohexane, marketed under the name PF 5050® by 3M, or bromoperfluorooctyl marketed under the name FORALKYL® by Atochem; nonafluoromethoxybutane and nonafluoroethoxyisobutane;perfluoromorpholine derivatives such as 4-trifluoromethyl perfluoromorpholine marketed under the name PF 5052® by 3M. 4) linear or branched saturated fatty alcohols having 6 to 30 carbon atoms or 8 to 30 carbon atoms such as cetyl alcohol, stearyl alcohol and their mixture (cetyl stearyl alcohol), octyldodecanol, 2-butyloctanol, 2-hexyldecanol, 2-undecylpentadecanol, oleic alcohol and linoleic alcohol. ;

[0074] In some embodiments, the at least one oil is an organic compound that is insoluble in water at ordinary room temperature (25°C) and atmospheric pressure (760 mmHg). In some embodiments, the at least one fat has a water solubility of less than 5%. In some embodiments, the at least one oil has a water solubility of less than 1%. In some embodiments, the at least one fat has a water solubility of less than 0.1%. Although these oils are given by way of example, it should be noted that other compounds compatible with cosmetic applications known in the art may be used.

[0075] In some embodiments, a skin-lightening cosmetic composition comprises at least one oil selected from lower C6-C16 alkanes, non-siliconized oils of alcohols of animal, vegetable, mineral, or synthetic origin, fatty acids, fatty acid esters and / or fatty alcohol esters, silicone-free waxes, silicones, and combinations thereof. In some embodiments, the at least one oil comprises a mineral oil, squalene, liquid petrolatum, polydecenes, a silicone oil, liquid esters of fatty acids and / or fatty alcohols, or combinations thereof. In some particular embodiments, the oil comprises one or more of the following: hemisqualane, dimethicone, squalane, and combinations thereof.

[0076] According to the various embodiments, the amounts of oils present in the oxidizing component of the skin-enhancing system can range from approximately 20% to approximately 80%, or from approximately 35% to approximately 60%, from approximately 40% to approximately 59%, from approximately 45% to approximately 58%, from approximately 50% to approximately 57%, from approximately 52% to approximately 56%, from approximately 30% to approximately 55%, from approximately 30% to approximately 60%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the oxidizing component of the skin-enhancing system. In some embodiments, the oxidizing component of the skin-enhancing system comprises at least approximately 2% of the oil. And, in some embodiments, the oxidizing component of the skin-enhancing system comprises at least approximately 50% of the oil.Thus, in some embodiments, the oil is present in an amount not less than approximately 20%, or approximately 50%, based on the total weight of the oxidizing component of the skin-enhancing system. Those skilled in the art, however, will appreciate that other ranges lie within the scope of the invention. In some embodiments, two or more oils are present. And, in some embodiments, one or more oils are present, at least one of which is an oxidation-resistant oil.

[0077] Thus, any one or combination of oils may be present, by weight, based on the weight of the oxidizing component of the skin-enhancing system, each or the combination present of approximately 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, up to about 80 percent by weight, including increments and ranges within and between them. Solvent

[0078] According to the description, one or more solvents are present in the oxidizing component of the skin improvement system. The solvent present in the oxidizing component of the skin improvement system includes, in particular, Water, alcohol, propylene glycol, or combinations thereof. Although these solvents are given as examples, it should be noted that other solvents compatible with cosmetic applications known in the art may be used.

[0079] According to the various embodiments, the solvent is present in a given composition in an amount from approximately 1% to approximately 70%, or any appropriate combination, subcombination, range, or subrange thereof by weight, based on the weight of the oxidizing component of the skin-enhancing system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0080] Thus, one or a combination of solvents may be present, by weight, based on the weight of the oxidizing component of the skin improvement system, each or the combination present in approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, up to approximately 70 percent by weight, including increments and the intervals within and between them. Water

[0081] The oxidizing component of skin-enhancing systems comprises from approximately 1 to approximately 95% by weight of water, relative to the total weight of the oxidizing component of the skin-enhancing system. In some embodiments, the amount of water in the oxidizing component of the skin-enhancing system may range from approximately 1 to approximately 70%, or any appropriate combination, subcombination, range, or subrange thereof by weight, based on the weight of the oxidizing component of the skin-enhancing system.

[0082] The pH of the oxidizing component of the skin improvement system is not limited but is generally between 3 and 10, and in some embodiments it is between 3 and 11, and between 5 and 9, and between 6 and 8 and 7. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the oxidizing component of the skin improvement system, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, 1,3-propanediamine or sodium phosphate, phosphoric acid, citric acid, sodium hydroxide or combinations thereof.Therefore, in some embodiments of the skin enhancement system in which the pH is between 3 and 5, inorganic acid, for example phosphoric acid, is added to adjust the pH, and in other embodiments, in which the pH is between 5 and 10, a second pH-adjusting composition with a basic pH can be mixed with the oxidizing component before application to obtain a higher pH.

[0083] Thus, water can be present by weight, based on the weight of the oxidizing component of the skin improvement system, of approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 75, 80, 85, 90 to approximately 95 percent in Weight, including increments and ranges within and between these values. Surfactant

[0084] In some embodiments, the oxidizing component of the skin-enhancing system may comprise at least one surfactant. This at least one surfactant may be selected from nonionic and anionic surfactants. In some embodiments, the oxidizing component of the skin-enhancing system comprises one, two, three, or more surfactants. In some examples of embodiments, the surfactant(s) are nonionic. In some embodiments, the at least one surfactant comprises nonionic mono-alkylated or polyoxyalkylated surfactants, nonionic mono-glycerolated or poly-glycerolated surfactants, nonionic alkylpolyglucoside surfactants, or combinations thereof. In some embodiments, the oxidizing component of the skin-enhancing system comprises at least one nonionic surfactant.In some embodiments, the oxidizing component of the skin-enhancing system comprises two or more surfactants, and in some of these embodiments, at least one surfactant has a low HLB (about 5) and at least one surfactant has a high HLB (about 15).

[0085] By way of example of anionic surfactants, one may mention, in particular, the salts (in particular the salts of alkali metals, for example sodium salts, the salts of amines such as amino alcohol salts or the salts of alkaline earth metals such as magnesium salts) of the following compounds: alkyl sulfates, alkyl ethersulfates, alkylamidoethersulfates, alkylarylpolyethersulfates, monoglyceride sulfates; alkylsulfonates, alkylamidesulfonates, alkylarylsulfonates, α-olefin sulfonates, paraffin sulfonates; alkyl phosphates, alkyl ether phosphates; alkylsulfosuccinates, alkylethersulfosuccinates, alkylamidesulfosuccinates; alkylsulfosuccinamates; alkyl sulfoacetates; acylsarcosinates; acylisethionates and N-acyltaurates;Fatty acid salts such as oleic acid, ricinoleic acid, palmitic acid or stearic acid, coconut oil acid or hydrogenated coconut oil acid; alkyl-D-galactoside uronic acid salts; acyllactylates; salts of polyoxyalkylenated alkyl ether carboxylic acids, polyoxyalkylenated alkylaryl ether carboxylic acids or polyoxyalkylenated alkylamido ether carboxylic acids, in particular those having 2 to 50 ethylene oxide groups and their combinations.

[0086] Examples of nonionic surfactants include, in particular, monooxyalkylated or polyoxyalkylated nonionic surfactants, monoglycerolated or polyglycerolated nonionic surfactants, or alkyl polyglucosides. The oxyalkylene motifs may be oxyethylene or oxypropylene motifs or a combination thereof. In some embodiments, the oxyalkylene motifs are oxyethylene motifs.Examples of nonionic oxyalkylated surfactants include, among others: oxyalkylated (C8-C24) saturated or unsaturated linear or branched alkylphenols; oxyalkylated C8-C30 saturated or unsaturated linear or branched alcohols; oxyalkylated C8-C30 amides; esters of saturated or unsaturated linear or branched C8-C30 acids and polyethylene glycols; polyoxyethylenated esters of saturated or unsaturated linear or branched C8-C30 acids and sorbitol; oxyethylenated saturated or unsaturated vegetable oils; condensates of ethylene oxide and / or propylene oxide, among others, alone or in mixtures. Examples of alkyl polyglucosides include, among others, decyl glucoside, caprylyl / capryl glucoside, lauryl glucoside, coco-glucoside, cetostearyl glucoside possibly mixed with cetostearyl alcohol, arachidyl glucoside, cocoylethyl glucoside and their combinations.

[0087] In some embodiments, at least one surfactant present in the oxidizing component of the skin enhancement system is a non-ionic surfactant. In certain exemplary embodiments, one or more surfactants in the oxidizing component of the skin-enhancing system are selected from (C8-C24) oxyalkylened alkylphenols, saturated or unsaturated, linear or branched, C8-C30 oxyalkylened alcohols, saturated or unsaturated, linear or branched C8-C30 oxyalkylened amides, esters of C8-C30 acids, saturated or unsaturated, linear or branched, and polyethylene glycols, polyoxyethylenated esters of C8-C30 acids, saturated or unsaturated, linear or branched, and sorbitol, saturated or unsaturated, oxyethylenated vegetable oils, condensates of ethylene oxide and / or propylene oxide and combinations thereof.In some exemplary embodiments, a composition comprises at least two nonionic surfactants selected from C8-C30 oxyethylenated alcohols, linear or branched, saturated or unsaturated C8-C30 polyoxyethylenated acid esters, and polyoxyethylenated sorbitol esters.

[0088] In some embodiments, the oxidizing component of the skin-enhancing system comprises two or more surfactants, and in some of these embodiments, at least one surfactant has a low HLB (about 5), and in the range of about 1 to 8, preferably 3 < HLB <, and at least one surfactant has a high HLB (about 15) and in the range of about 8 to 25, preferably 10 < HLB < 16. In some embodiments, at least one surfactant has an HLB in the range of 1 to about 8, for example about 1, 2, 3, 4, 5, 6, 7, or 8, and at least one surfactant has an HLB in the range of about 8 to about 25, for example about 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 or 25. In some exemplary embodiments, a composition comprises one or more of ceteth-2 (HLB-5) and steareth-2 (HLB-5), and one or more of decyl glucoside (HLB-13-15) and steareth-20 (HLB-15).

[0089] In some embodiments, at least one surfactant is present in the oxidizing component of the skin enhancement system in an amount ranging from about 0.1% to about 15% by weight relative to the weight of the oxidizing component of the skin enhancement system.

[0090] In certain embodiments, at least one surfactant is present in the oxidizing component of the skin enhancement system in an amount ranging from about 0.5% to about 3.5% by weight, including increments and ranges within and between them, based on the total weight of the oxidizing component of the skin enhancement system.

[0091] In some embodiments, one or more surfactants, alone or in combination, may be present in the oxidizing component of the skin enhancement system, and in some embodiments, each surfactant may be present from about 0.1% to about 5% by weight, from about 0.25% to about 2.5% by weight, from about 0.5% to about 1.8%, from about 0.5% to about 1.25% and from about 0.5% to about 0.8%, or any combination, subcombination, range or subrange of the latter by weight, based on the weight of the oxidizing component of the skin enhancement system.

[0092] It should be noted that in some embodiments, the skin-enhancing system is free or essentially free of surfactant. In some embodiments, the oxidizing component of the skin-enhancing system is at least free or essentially free of surfactant.

[0093] Thus, one or a combination of surfactants, if present, may be present, by weight, on the basis of the weight of the oxidizing component of the skin enhancement system, each or the combination present from about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, up to about 15 percent by weight, including increments and ranges within and between them. Polymer

[0094] In certain embodiments, one or more other components, such as polymers, may be present in the oxidizing component of the skin-enhancing system at a concentration of approximately 0.05% to approximately 50% by weight, approximately 0.05% to approximately 15% by weight, approximately 0.1% to approximately 2%, approximately 0.25% to approximately 1.5%, and approximately 0.25% to approximately 0.5%, or any appropriate combination, subcombination, range, or subrange thereof by weight, based on the weight of the oxidizing component. of the skin improvement system. Those skilled in the art, however, will appreciate that other areas fall within the scope of the invention. In some embodiments, the polymers are selected from fatty acid amides, cellulosic thickeners, guar gum and its derivatives, microbial gum, carrageenan, crosslinked homopolymers of acrylic acid or acrylamidopropane sulfonic acid, and associative polymers. In some exemplary embodiments, the polymers are selected from cetylhydroxyethylcellulose, sclerotium gum at 1% or more by weight, and combinations thereof.

[0095] Thus, one or a combination of polymers may be present, by weight, based on the weight of the oxidizing component of the skin-enhancing system, each or the combination present in approximately 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 at approximately 50 percent by weight, including the increments and ranges within and between these.

[0096] SKIN IMPROVEMENT TREATMENT CHEMICAL PEEL COMPONENT

[0097] In various embodiments, the chemical peeling component of the skin-enhancing system comprises at least one or a combination of alpha-hydroxy acids and at least one or a combination of beta-hydroxy acids. In some embodiments, the chemical peeling component of the skin-enhancing system comprises at least one alpha-hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid.The chemical peeling component of the skin enhancement system also includes one or more additional ingredients, including water, and one or more ingredients selected from the group consisting of one or more oils, one or more water-based solvents, one or more surfactants, one or more thickeners, phenylethyl resorcinol, and one or more additional ingredients selected from, among others, chelating agents, pH regulators, active components, humectants, antioxidants, plant extracts, vegetable oils and butters, perfumes, pearlescent agents, odor absorbers, coloring materials, essential oils, vitamins, antimicrobials, preservatives, and combinations thereof.

[0098] In certain particular embodiments, the chemical peeling component of the skin improvement system is a creamy emulsion that may be thick or liquid (fluid). In certain particular embodiments, the chemical peeling component of the skin improvement system is a liquid toner. The chemical peeling component may be supplied in a form that It can be rinsed off or left on. For example, the chemical peeling component can be used in the form of a creamy emulsion, such as a rinse-off mask, or as a leave-on toner. Other formulations are possible, and the examples provided are not exhaustive. More generally, the chemical peeling component can be supplied as a leave-on or rinse-off formulation and in a form selected from the group consisting of a suspension, emulsion cream, serum, essence, gel, or toner, and can be packaged in a form such as a stick, spray, ointment, paste, mousse, foam, shaving cream, wipe, patch, strip, film-forming product, mask, and combinations thereof.

[0099] In certain particular embodiments, the chemical peeling component of the skin improvement system is a creamy emulsion form that may be thick or liquid (fluid). According to some examples of embodiments in which the chemical peeling component of the skin improvement system is a creamy emulsion form, the composition may include at least one alpha hydroxy acid comprising lactic acid and at least one beta hydroxy acid comprising salicylic acid, an oil or a combination of vegetable oils or butters, one or a combination of surfactants, one or more thickeners, one or more water-based solvents, for example, glycerin, one or more vitamin actives, one or more preservatives, chelating agents or pH regulators, and water present in an amount of approximately 40% to approximately 50%, by weight, based on the weight of the skin component.

[0100] In certain particular embodiments, the chemical peeling component of the skin improvement system is a toner, in which the composition may include at least one alpha hydroxy acid comprising lactic acid and at least one beta hydroxy acid comprising salicylic acid, one or a combination of oils including squalane and nut oils, one or a combination of surfactants including betaine, one or more thickeners including carrageenan, one or more water-based solvents, for example, glycerin or propanediol, one or more actives including hyaluronic acid, one or more perfumes, preservatives, chelating agents or pH adjusters, and water present in an amount of about 70% to about 75%, by weight, based on the weight of the skin exfoliating component.And in certain particular embodiments, the chemical peeling component of the skin improvement system is a tonic, the composition of which may include at least one alpha hydroxy acid comprising lactic acid and at least one beta hydroxy acid comprising salicylic acid, phenylethyl re-sorcinol, one or a combination of water-based solvents comprising denatured alcohol, one or more preservatives, chelating agents or pH and pH adjusters. water is present in an amount of approximately 70% to approximately 75%, by weight, based on the weight of the skin component.

[0101] Accordingly, the various ingredients that may be present in the oxidizing component of the skin enhancement system are provided below or further in this document in the section described as other ingredients, and as shown in the examples herein. Alpha Hydroxyacid

[0102] According to the various embodiments, the chemical peeling component of the skin enhancement system comprises at least one alpha hydroxy acid.

[0103] Suitable alpha-hydroxy acids include glycolic acid, lactic acid, tartaric acid, mandelic acid, citric acid, their ester derivatives, and combinations thereof. Examples of ester derivatives include lactic acid ester compounds, such as methyl lactate, ethyl lactate, butyl lactate, and similarly, ester compounds of glycolic acid, tartaric acid, mandelic acid, and citric acid. A particularly suitable alpha-hydroxy acid is lactic acid. Lactic acid, or 2-hydroxypropanoic acid, is supplied to the chemical peeling composition to provide enhanced skin exfoliation. In addition, lactic acid also stimulates the production of glycosaminoglycans (GAGs) in the skin, thereby improving the skin's barrier function and hydration.

[0104] And in certain particular embodiments, the alpha hydroxy acid in the chemical peeling component of the skin enhancement system excludes at least one of the elements among lactic acid, glycolic acid, tartaric acid, mandelic acid and citric acid.

[0105] The chemical peeling component of the skin improvement system comprises an alpha hydroxy acid concentration in the range of approximately 4% to approximately 15%, or approximately 8% to approximately 14%, or approximately 9% to approximately 13%, or approximately 10% to approximately 12%, or is approximately 10%, or any suitable combination, sub-combination, range, or sub-range of these by weight, based on the weight of the chemical peeling component of the skin improvement system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention. According to some embodiments, the amount of alpha hydroxy acid present is not greater than approximately 10%.

[0106] Thus, any one or combination of alpha-hydroxy acid is present, by weight, on the basis of the total weight of the chemical peeling component of the skin enhancement system, from about 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, up to about 15 percent by weight, including increments and ranges within and between them. Beta hydroxy acid

[0107] According to the various embodiments, the chemical peeling component of the skin-enhancing system may comprise at least one beta-hydroxy acid. In certain particular embodiments, the chemical peeling component of the skin-enhancing system may comprise a beta-hydroxy acid comprising salicylic acid.

[0108] According to the present invention, "beta-hydroxy acid" means a carboxylic acid comprising a hydroxyl group and a carboxyl group separated by two carbon atoms. A beta-hydroxy acid may be present in the chemical peeling component of the skin improvement system in the form of a free acid and / or in the form of one of its associated salts (in particular, salts of an organic base or an alkali metal), depending in particular on the final pH imposed on the chemical peeling component of the skin improvement system.

[0109] Suitable beta-hydroxy acids include salicylic acid and its derivatives (including 5-n-octanoylsalicylic acid, salicylate, sodium salicylate and willow extract), capryloyl salicylic acid, beta-hydroxybutanoic acid, propionic acid, beta-hydroxy beta-methylbutyric acid, tropic carnitine and trethocanic acid, and combinations thereof.

[0110] And in certain particular embodiments, the beta-hydroxy acid in the chemical peeling component of the skin enhancement system excludes at least one of salicylic acid and its derivatives (including 5-n-octanoylsalicylic acid, salicylate, sodium salicylate and willow extract), capryloyl salicylic acid, beta hydroxybutanoic acid, propionic acid, beta-hydroxy beta-methylbutyric acid, tropic carnitine and trethocanic acid.

[0111] The chemical peeling component of the skin improvement system may comprise a concentration of beta hydroxy acid in the range of approximately 0.1% up to and a maximum of approximately 2% beta hydroxy acid, by weight, based on the total weight of the chemical peeling component of the skin improvement system. In some embodiments, the chemical peeling component of the skin improvement system comprises up to a maximum of approximately 2% or approximately 1.9% beta hydroxy acid. In some embodiments, the chemical peeling component of the skin improvement system comprises up to a maximum of approximately 1% beta hydroxy acid. According to some embodiments, the amount of beta hydroxy acid present does not exceed approximately 0.40% up to approximately 0.50%.In some embodiments, the chemical peeling component of the skin enhancement system comprises about 0.1% to about 1% beta-hydroxy acid, or about 0.2% to about 2.0%, or about 0.1% to about 1.5%, or about 0.2% to about 1.5%, or about 0.3% to about 1.0%, or . from approximately 0.35% to approximately 0.75%, or from approximately 0.4% to approximately 0.5%, or is equal to approximately 0.45%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peeling component of the skin enhancement system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0112] Thus, the at least one beta-hydroxy acid, when present, is present in the chemical peeling component of the skin enhancement system at a rate of approximately 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, up to approximately 2.0 percent by weight, including increments and all ranges and sub-ranges within and between them. Polyhydroxyacid

[0113] According to the various embodiments, the chemical peeling component of the skin enhancement system may include at least one polyhydroxy acid.

[0114] Suitable polyhydroxy acids include gluconolactone and its derivatives and their combinations.

[0115] The chemical peeling component of the skin improvement system comprises an alpha hydroxy acid concentration in the range of approximately 4% to approximately 15%, or approximately 8% to approximately 14%, or approximately 9% to approximately 13%, or approximately 10% to approximately 12%, or is approximately 10%, or any suitable combination, sub-combination, range, or sub-range of the latter by weight, based on the weight of the chemical peeling component of the skin improvement system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention. According to certain embodiments, the amount of polyhydroxy acid present is not greater than approximately 10%.

[0116] Thus, any one or combination of polyhydroxy acid, when present, is present, by weight, on the basis of the total weight of the chemical peeling component of the skin enhancement system, from about 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, up to about 15 percent by weight, including the increments and ranges within and between them. Phenylethyl resorcinol

[0117] According to certain embodiments, the chemical peeling component of the skin enhancement system may include phenylethyl resorcinol.

[0118] Phenylethyl resorcinol acts as a tyrosinase inhibitor. When used in the chemical peeling component of the skin improvement system, phenylethyl resorcinol effectively whitens the skin and reduces uneven skin tone. Phenylethyl resorcinol showed no adverse effects in basic toxicological tests, including acute oral toxicity, mutagenicity, and irritation. cutaneous, skin sensitization and phototoxicity.

[0119] According to the various embodiments, when present, the amount of phenylethyl resorcinol in the chemical peeling component of the skin enhancement system is approximately 0.2% to approximately 2.0%, or approximately 0.2% to approximately 1.5%, or approximately 0.4% to approximately 1.0%, or approximately 0.6% to approximately 0.9%, or approximately 0.7% to approximately 0.8%, or approximately 0.2% to approximately 0.8%, or approximately 0.75%, or any suitable combination, subcombination, range, or subrange thereof by weight, based on the weight of the chemical peeling component of the skin enhancement system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention. According to certain embodiments, the amount of phenylethyl resorcinol present is not more than about 0.2% up to about 0.8%.

[0120] Thus, phenylethyl resorcinol, when present in the chemical peeling component of the skin enhancement system, is present, by weight, on the basis of the total weight of the chemical peeling component of the skin enhancement system, from about 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 to about 2.0 percent by weight, including the increments and ranges within and between them. Oil

[0121] According to the various embodiments, the chemical peeling component of the skin enhancement system may comprise one or more water-immiscible oils.

[0122] In certain particular embodiments, the chemical peeling component in emulsion form may comprise one or more oils selected from the group consisting of C12-15 alkyl benzoate, caprylic / capric triglyceride, theobroma cacao (cocoa) seed butter, butyrospermum parkii (shea) butter, coco-caprylate / caprate and their combinations.

[0123] In various embodiments, and in certain particular embodiments, the chemical peeling component in emulsion form comprises at least one mild emollient selected from polar emollients and linear liquid alkanes. In certain particular embodiments, the composition comprises one or a combination of coco-caprylate / caprate or C15-19 alkane.

[0124] At least one mild emollient is present in a range of approximately 0.5% to approximately 15%, or approximately 1% to approximately 12%, or approximately 1% to approximately 10%, or approximately 2% to approximately 8%, or any suitable combination, sub-combination, range, or sub-range of these by weight, based on the weight of the chemical peeling component. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0125] Other suitable polar emollients may be selected from the group consisting of isopropyl myristate, dicaprylyl ether, ethylhexyl palmitate, isopropyl palmitate, cetearyl ethylhexanoate, isononyl isononanoate, isopropyl isostearate, diisopropyl sebacate, coco caprylate / caprate, diisopropyl adipate and their combinations.

[0126] Other suitable linear liquid alkanes (in Cl 1 to C20) may be chosen from the group consisting of isohexadecane, C15-19 alkane, isododecane, undecane, tridecane, dodecane and their combinations.

[0127] In certain particular embodiments, the chemical peeling component comprises coco-caprylate / caprate, a C15-19 alkane, dodecane and combinations thereof.

[0128] Thus, any one or combination of mild emollients is present, by weight, on the basis of the total weight of the chemical peeling component, from about 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, up to about 15 percent by weight, including increments and ranges within and between them.

[0129] In certain particular embodiments, the chemical peeling component in the form of a tonic may comprise one or more oils selected from the group consisting of dicaprylyl ether, macadamia ternifolia seed oil, squalane and combinations thereof.

[0130] In the various embodiments, the oil is generally immiscible in water and may be selected from hydrocarbons, silicones, fatty alcohols, glycols, and vegetable oils. The oil may comprise one or a combination of polar and nonpolar oils. In some embodiments, the oil may be selected from vegetable hydrocarbon oils, mineral oils, ester oils, fatty alcohols containing 12 to 26 carbon atoms, fatty acids containing 12 to 26 carbon atoms, and vinylpyrrolidone copolymers and combinations thereof.In certain specific embodiments, an oil may be selected from purcelline oil (cetostearyl octanoate), squalane, hemisqualane, isononyl isononanoate, C12-C15 alkyl benzoate, 2-ethylhexyl palmitate, isodecyl neopentanoate, tridecyl neopentanoate, octyldodecyl neopentanoate, 2,2-octyldodecyl stearate, 2-octyldodecyl erucate, oleyl erucate, isostearyl isostearate, 2-octyldodecyl benzoate, alcohol or polyalcohol octanoates, decanoates or ricinoleates, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, 2-ethylhexyl palmitate, 2-hexyldecyl laurate, 2-hexyl palmitate, palmitate, 2-octyldodecyl myristate and 2-diethylhexyl succinate, cocoglyceride, cyclomethicone, dimethicone, dicaprylyl carbonate, dicapryl maleate, caprylic / capric triglyceride, isopropyl myristate, the . octyl stearate, isostearyl linoleate, lanolin oil, coconut oil, cocoa butter, avocado oil, aloe extracts, jojoba oil, castor oil, fatty acid, oleic acid, stearic acid, fatty alcohol, cetyl alcohol, hexadecyl alcohol, diisopropyl adipate, hydroxybenzoate esters, benzoic acid esters of C9-C15 alcohols, alkanes, mineral oil, silicone, dimethyl polysiloxane, ether, polyoxypropylene butyl ether, polyoxypropylene cetyl ether, C12-C15 alkyl benzoate, aryl alkyl benzoate, isopropyl lauroyl sarcosinate and all combinations thereof.

[0131] In certain particular embodiments, the oil is selected from C13-15 alkane (hemisqualane), dicaprylyl carbonate, isononyl isononanoate, isopropyl myristate, dimethicone, squalane, and mineral oil. In one exemplary embodiment, the oil comprises one or a combination of C3-15 alkane (hemisqualane), dicaprylyl carbonate, isononyl isononanoate, isopropyl myristate, dimethicone, squalane, and mineral oil. In some embodiments, the oil in the chemical peeling component of the skin-enhancing system comprises isopropyl myristate.

[0132] According to the various embodiments, the additional oil, when present, in the chemical peeling component is currently from about 1% to about 20%. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention. The chemical peeling component may comprise more than one oil, such as a mixture of oils in which one or the mixture of oils is present in an amount which, alone or in combination, is present from about 1% to about 20% by weight based on the weight of the chemical peeling component, and in which the total amount of additional oil is present up to about 20% of the chemical peeling component.

[0133] According to some embodiments, the chemical peeling component may include at least one vegetable butter, at least one butter selected from the group consisting of butyrospermum parkii (shea) butter, theobroma cacao (cocoa) seed butter, almond butter, aloe butter, apricot kernel butter, avocado butter, coconut cream butter, cupuaçu butter, dhupu butter, hemp butter, jojoba butter, kokum butter, macadamia nut butter, mango butter and combinations thereof.

[0134] According to the various embodiments, the amount of butter present in the chemical peeling component may be at least 1%, alternatively from about 1% to about 10%; alternatively, from about 2% to about 9%, alternatively from about 3% to about 8%, alternatively from about 4% to about 7%, alternatively from about 5% to about 6%, or any combination, sub-combination, range, or an appropriate sub-range thereof by weight, based on the weight of the chemical peeling component. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0135] In some embodiments, at least one butter has a melting point in the range of about 30 to about 45 degrees Celsius.

[0136] Thus, any one or combination of oils may be present, by weight, on the basis of the total weight of the chemical peeling component, from about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, up to about 20 percent by weight, including the increments and ranges between these and between them.

[0137] In certain embodiments, when present, the amount of at least one oil in the chemical peeling component of the skin-enhancing system may be at least about 20%, and may range from about 20% to about 60%, or from about 25% to about 55%, or from about 30% to about 50%, or any appropriate combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peeling component of the skin-enhancing system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.The chemical peeling component of the skin improvement system may comprise more than one oil, such as a mixture of oils in which one or the mixture of oils is present in an amount which, alone or in combination, is at least 20% by weight based on the weight of the chemical peeling component of the skin improvement system, and in which the total amount of oil is present up to about 60% of the chemical peeling component of the skin improvement system.

[0138] Thus, any one or combination of oils may be present, by weight, on the basis of the total weight of the chemical peeling component of the skin enhancement system, from about at least 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 31, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59 to about 60 percent by weight, including the increments and ranges between these and between them. Solvent

[0139] According to the various embodiments, water is present in the chemical peeling component of the skin improvement system in a range of approximately 20% to approximately 80%, or approximately 30% to approximately 60%, or approximately 35% to approximately 50%, or approximately 45% to approximately 49%, or approximately 60% to approximately 80%, or approximately 65% ​​to approximately 75%, or any appropriate combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peeling component of the skin improvement system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0140] In certain particular embodiments, in which the chemical peeling component is in the form of an emulsion, water is present in the chemical peeling component of the skin enhancement system in a range of about 20% to about 80%, or about 30% to about 60%, or about 35% to about 50%, or about 45% to about 49%, or any appropriate combination, subcombination, range or subrange of these by weight, based on the weight of the chemical peeling component of the skin enhancement system.

[0141] In certain particular embodiments, in which the chemical peeling component is a form of toner, water is present in the chemical peeling component of the skin-enhancing system in a range of approximately 20% to approximately 80%, or approximately 60% to approximately 80%, or approximately 65% ​​to approximately 75%, or any appropriate combination, subcombination, range, or subrange thereof by weight, based on the weight of the chemical peeling component of the skin-enhancing system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0142] Thus, water is present, by weight, on the basis of the total weight of the chemical peeling component of the skin enhancement system, from about 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 31, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59 to about 60 percent by weight, including increments and ranges within and between these values.

[0143] In certain embodiments, water is present in the chemical peeling component in a range of approximately 40% to approximately 60%, or approximately 45% to approximately 55%, or approximately 48% to approximately 50%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peeling component. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0144] Thus, in certain embodiments, water is present, by weight, based on the total weight of the chemical peeling component, from about 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59 to about 60 percent by weight, including increments and ranges within and between these values.

[0145] The water used in the photoprotective composition may be sterile demineralized water and / or floral water such as rose water, corn water, chamomile water or lime water and / or natural thermal water or mineral water such as, for example: Vittel water, Vichy basin water, Uriage water, La Roche Posay water, La Bourboule water, Enghien-les-Bains water, Saint Gervais-les-Bains water, Neris-les-Bains water, Allevar-les-Bains water, Digne water, Maizieres water, Neyrac-les-Bains water, Lons-le-Saunier water, water Good waters, water from Rochefort, Saint Christau water, Les Fumades water, Tercis-les-Bains water, or Avène water. The aqueous phase may also include reconstituted thermal water, that is, water containing trace elements such as zinc, copper, magnesium, etc., recreating the characteristics of thermal water.

[0146] The pH of the chemical peeling component of the skin improvement system is not limited but is generally not less than 3. In some embodiments, the pH of the chemical peeling component is not limited but is generally not less than 3, and more particularly in a range of about 3 to about 4.5, or about 3.5 to about 4.1 or about 3.8. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the chemical peeling component, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3-propanediamine, or by adding a mineral or organic acid, advantageously a carboxylic acid, such as citric acid.

[0147] In some embodiments, the chemical peeling component comprises one or more water-based solvents selected from the group consisting of glycols, for example, glycerin and pentylene glycol, alcohols for solubilizing the acid, for example, monoalcohols such as C1-C8 monohydric alcohols like ethanol, propanol, butanol, isopropanol, isobutanol, benzyl alcohol, and phenylethyl alcohol, and combinations thereof. In some embodiments, the water-based solvents include glycerin and pentylene glycol. In some embodiments, the glycerin content ranges from approximately 5% to approximately 20%.

[0148] According to the various embodiments, the amount of water-based solvent present in the chemical peeling component is in the range of approximately 1% to approximately 20%, or approximately 2% to approximately 18%, or approximately 10% to approximately 15%, or any appropriate combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peeling component. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0149] Thus, any one or combination of water-based solvents may be present, by weight, on the basis of the total weight of the chemical peeling component, from about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, up to about 20 percent by weight, including increments and ranges within and between these values.

[0150] In some embodiments, the chemical peeling component of the skin improvement system comprises one or more solvents including alcohol As a solubilizing acid, for example, monoalcohols such as the monoalcohol C1-C8 of alcohols such as ethanol, propanol, butanol, isopropanol, isobutanol, and benzyl alcohol and phenylethyl alcohol. In some embodiments, the alcoholic solvent is chosen from one or a combination of ethanol and isopropyl alcohol.

[0151] According to the various embodiments, the amount of alcohol present in the chemical peeling component of the skin improvement system is in the range of approximately 5% to approximately 20%, or approximately 6% to approximately 18%, or approximately 10% to approximately 15%, or any appropriate combination, sub-combination, range, or sub-range of these values ​​by weight, based on the weight of the chemical peeling component of the skin improvement system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0152] Thus, any one or combination of alcohols may be present, by weight, on the basis of the total weight of the chemical peeling component of the skin enhancement system, from about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, up to about 20 percent by weight, including increments and ranges within and between these values. Surfactant

[0153] According to the description, the chemical peeling component of the skin enhancement system comprises one or more surfactants.

[0154] According to certain particular embodiments, the chemical peeling component comprises a mixture of surfactants including one or a combination of surfactants, for example selected from the group consisting of stearic acid, polysorbate 20, glyceryl stearate (and) PEG-100 stearate, cetearyl alcohol (and) ceteareth-20, and glyceryl stearate, sorbitan stearate and combinations thereof.

[0155] According to certain particular embodiments, the chemical peeling component comprises a mixture of surfactants comprising at least stearic acid, polysorbate 20, glyceryl stearate (and) PEG-100 stearate, cetearyl alcohol (and) ceteareth-20 and glyceryl stearate.

[0156] In accordance with such embodiments, the amount of surfactant present in the composition can be from about 1% to about 20%, alternatively from about 2% to about 19%, alternatively from about 3% to about 18%, alternatively from about 4% to approximately 17%, or approximately 5% to approximately 16%, or approximately 6% to approximately 15%, or approximately 7% to approximately 14%, or approximately 8% to approximately 13%, or approximately 9% to approximately 12%, or approximately 10% to approximately 11%, or any appropriate combination, sub-combination, range, or sub-range of these by weight, based on the weight of the composition. The man of the The profession, however, will appreciate that other areas fall within the scope of the invention.

[0157] In some embodiments, the selected surfactants are sulfate-free. In certain specific embodiments, the surfactant mixture comprises two or more sulfate-free surfactants. The term "sulfate-free" as used here means that sulfate has not been added as a component. In some embodiments, a composition is sulfate-free. Those skilled in the art will understand that sulfate may be present in a composition through its presence in one or more of the formulation's components; thus, in some embodiments, a composition may be "essentially sulfate-free" when sulfate is present at a concentration not exceeding 5% by weight, and in some cases not exceeding 3% by weight, and in some cases not exceeding 1% by weight, based on the weight of the cleaning composition. Therefore, the term "sulfate-free" means that the surfactant does not contain sulfate.

[0158] According to these embodiments, each of the surfactants in the surfactant mixture is present in the composition in an amount of approximately 0.5% to approximately 8%, or approximately 1% to approximately 4%, or any appropriate combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the moisturizing peeling cream. In some embodiments, a surfactant mixture is present in the composition in an amount of approximately 5% to approximately 8%, or any appropriate combination, sub-combination, range, or sub-range of these values ​​by weight, based on the weight of the moisturizing exfoliating cream. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0159] Thus, each of the surfactants, in particular when selected from stearic acid, polysorbate 20, glyceryl stearate (and) PEG-100 stearate, cetearyl alcohol (and) ceteareth-20, and glyceryl stearate, alone or in combination, is present in an amount by weight, based on the total weight of the moisturizing skin cream, of about 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7 to about 8 percent by weight, including the increments and pages within and between these values.

[0160] In some embodiments, the surfactants are selected from anionic surfactants, amphoteric / zwitterionic surfactants, and nonionic surfactants. According to some embodiments, the chemical peeling component of the skin-enhancing system comprises a surfactant or a mixture of surfactants that includes two or more surfactants selected from anionic surfactants, amphoteric / zwitterionic surfactants, nonionic surfactants, and combinations thereof. In some of these embodiments, the mixture of two or more surfactants includes surfactants that are selected from only one of the anionic surfactants, amphoteric / zwitterionic surfactants, or nonionic surfactants. In some embodiments, the mixture of two or more surfactants includes Surfactants are selected from at least two anionic surfactants, amphoteric / zwitterionic surfactants, and nonionic surfactants. In some embodiments, the surfactant mixture comprises only two surfactants. In other embodiments, the surfactant mixture comprises three or more surfactants.

[0161] In some embodiments, the anionic surfactants may be selected from, for example, alkyl sulfonates, alkyl sulfosuccinates, alkyl ether sulfosuccinates, alkyl sulfoacetates, alkyl sulfosuccinamates, alkyl ether carboxylates, alkyl succinates, fatty acyl taurates, fatty acyl isethionates, fatty acyl sarcosinates, acyl glutamates, fatty acyl glycinates and alkyl phosphates.

[0162] In some embodiments, the amphoteric / zwitterionic surfactants may be selected from, for example, amphocarboxylates, alkylbetaines, amidoalkylbetaines, amphophosphates, phosphobetaines, pyrophosphobetaines, carboxyalkylpolyamines and amidoalkylsultaines.

[0163] In some embodiments, the non-ionic surfactants may be chosen from, for example, alkyl polyglucosides having alkyl groups with a carbon chain length from C10 to C16.

[0164] In some embodiments, the selected surfactants are sulfate-free. In some particular embodiments, the surfactant mixture comprises two or more surfactants that are sulfate-free. The term "sulfate-free" as used here means that sulfate has not been added as a component. In some embodiments, a composition is sulfate-free. Those skilled in the art will understand that sulfate may be present in a composition through its presence in one or more of the formulation components; thus, in some embodiments, a composition may be "essentially sulfate-free" when sulfate is present at a concentration not exceeding 5% by weight, and in some cases not exceeding 3% by weight, and in some cases is present at a maximum of 1% by weight, based on the weight of the cleaning composition.Thus, the term "sulfate-free" means that the surfactant does not contain sulfate.

[0165] According to the various embodiments, each of the surfactants in the surfactant mixture is present in the composition in an amount of approximately 2% to approximately 12%, or approximately 3% to approximately 4%, or any appropriate combination, sub-combination, range, or sub-range of these values ​​by weight, based on the weight of the chemical peeling component of the skin-enhancing system. In some embodiments, a surfactant mixture is present in the composition in an amount of approximately 4% to approximately 25%, or approximately 6% to approximately 12%, or approximately 6% to approximately 8%, or any appropriate combination, sub-combination, range, or sub-range of these values ​​by weight. a sub-range of these weight values, based on the weight of the chemical peeling component of the skin improvement system. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0166] Thus, each of the surfactants, alone or in combination, is present in an amount by weight, based on the total weight of the chemical peeling component of the skin enhancement system, of about 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, up to about 25 percent by weight, including increments and ranges. Thickening

[0167] According to the description, the chemical peeling component of the skin improvement system may include at least one thickener. In some embodiments, the chemical peeling component includes two or more thickeners. In some embodiments, the chemical peeling component includes one or a combination of thickeners selected from the group consisting of aluminum starch octenylsuccinate, xanthan gum, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, and combinations thereof. In some particular embodiments, the chemical peeling component includes aluminum starch octenylsuccinate, xanthan gum, and a hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer.

[0168] In some embodiments, the chemical peeling component of the skin-enhancing system comprises one or more thickeners for a water-based system, selected, for example, from acrylates / beheneth-25 methacrylate copolymer, acrylate copolymers, acrylate / alkyl acrylate Cl0-30 crosspolymer, sodium acrylate (and) caprylic / capric triglyceride copolymer, carbomer, xanthan gum, hydroxypropyl guar, carrageenan, ceratonia siliqua (locust bean gum), ammonium polyacryloyldimethyltaurate, ammonium acryloyldimethyltaurate / steareth-25 methacrylate crosspolymer, polyacrylate-6 crosspolymer, and combinations thereof. In some embodiments, the chemical peeling component of the skin-enhancing system comprises two or more thickeners.

[0169] In certain particular embodiments, the thickener(s), when present, comprise one or a combination of beheneth-25 acrylate / methacrylate copolymer and acrylate copolymer.

[0170] According to these embodiments which include one or more thickeners, each thickener is present in the composition in an amount of approximately 0.01% to approximately 15%, or approximately 1% to approximately 10%, or approximately 2% to approximately 5%, or approximately 1% to approximately 3%, or any appropriate combination, sub-combination, range or sub-range thereof by weight, based on the weight of the peeling component chemical. And in certain embodiments, the total amount of thickener present in the composition is at least about 3%, or about 4%, or about 10% or more, or in an amount of about 3% to about 15%, from about 3% to about 10%, or from about 3% to about 5%, or any suitable combination, subcombination, range, or subrange of these by weight, based on the weight of the chemical peeling component. Those skilled in the art, however, will appreciate that other ranges fall within the scope of the invention.

[0171] Thus, one or more thickeners in the chemical peeling component, when present, are present by weight, based on the total weight of the chemical peeling component, of approximately 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.5, 4.0, 4.5, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, up to about 15 percent, including increments and ranges within and between these values. OTHER INGREDIENTS

[0172] In accordance with the various embodiments, each of the oxidizing and chemical peeling components of the skin enhancement system may further comprise additional ingredients, generally including, but not limited to, chelating agents, pH regulators, active components, humectants, antioxidants, plant extracts, vegetable oils and butters, perfumes, pearlescent agents, odor absorbers, colorants, essential oils, vitamins, antimicrobials, and preservatives, and combinations thereof. Non-limiting examples of some of these optional additional ingredients are provided below. Chelating agent

[0173] In certain embodiments, one or more other components, such as chelating agents, may be present in one or both of the oxidizing component and the chemical peeling component of the skin enhancement system, in amounts of about 0.01% to about 2% by weight, about 0.02% to about 1.5% by weight, about 0.02% to about 1%, about 0.02% to about 0.5% and about 0.025% to about 0.15%, or any combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the oxidizing component or the chemical peeling component of the skin enhancement system. In some exemplary embodiments, the chelating agents are selected from ethylenediaminetetraacetic acid (EDTA), tetrasodium glutamate diacetate, tetrasodium etidronate, tetrasodium pyrophosphate, pentasodium ethylenediamine tetramethylene phosphonate, sodium etamine, and combinations thereof.

[0174] Thus, one or a combination of chelating agents may be present, by weight, on the based on the total weight of the skin enhancement system, each or combination present from approximately 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0 up to approximately 2 percent by weight, including increments and ranges between and between these. Optional active ingredients and other ingredients

[0175] In some embodiments, there may be one or more additives present in the skin improvement system, the additive being selected from, for example, humectants, such as acetamide MEA, glycols, such as glycerin and propylene glycol; alcohol; antimicrobial components, salicylic acid, alpha acid;antioxidants, including, in particular, phenolic compounds such as chalcones, flavones, flavanones, flavanols, flavonols, dihydroflavonols, isoflavonoids, neoflavonoids, catechins, anthocyanidins, tannins, lignans, auronoids, stilbenoids, alkylacenes, curcumins, hydroxybenzoketones, methoxyphenols, naphthoquinones and phenolic terpenes, resveratrol, curcumin, pinoresinol, ferulic acid, hydroxytyrosol, cinnamic acid, caffeic acid, p-coumaric acid, baicalin (Scutellaria Baicalensis root extract), pine bark extract (Pibud Pinaster bark extract), ellagic acid; Hyaluronic acid and its derivatives; and vitamins and vitamin derivatives, such as tocopherol and ascorbic acid and their combinations.

[0176] In some embodiments, the additives may comprise one or a combination of antimicrobial agents and their salts, selected for example from chlorphenesin, caprylyl glycol, phenoxyethanol, caprylhydroxamic acid, benzoic acid, salicylic acid, benzyl alcohol, phenethyl alcohol, benzalkonium chloride, 4-hydroxyacetophenone, piroctone olamine, hexyl glycerin, ethylhexylglycerin, octylglycerin, benzylglycerin, 3-heptoyl-2,2-propandiol and 1,2-hexandiol, pentylene glycol, and combinations thereof.

[0177] In certain embodiments, there may be one or more other additives present in the skin improvement system, the other components being selected from fillers such as clays; talc; powders, including spherical / silica powders and mineral powders; carbohydrate-based gelling agents; organic thickeners with, for example, anionic, cationic, non-ionic and amphoteric polymer associative thickeners and their combinations; penetrants; sequestrants; perfumes; dispersants; film-forming agents; ceramides; opacifiers and their combinations.

[0178] In certain embodiments, one or more additional ingredients may be selected from the group consisting of chelating agents, pH adjusters, humectants, antioxidants, plant extracts, vegetable oils and butters, active components, essential oils, vitamins, antimicrobials and preservatives, perfumes, pearlescent agents, odor absorbers, coloring materials, fillers such as clays, talc, powders, including spherical / silica powders and mineral powders, carbohydrate-based gelling agents, organic thickeners, penetrants, sequestrants, perfumes, dispersants, film-forming agents, ceramides, opacifiers and combinations thereof.

[0179] In certain particular embodiments, one or more additives in any of the components are chosen from the group consisting of sodium hydroxide, trisodium ethylenediamine disuccinate, tocopherol, hydrogen peroxide, chlorophenesin, salicylic acid, phenoxyethanol, bisabolol, sodium hydroxide, trisodium ethylenediamine disuccinate, tocopherol, sodium hyaluronate, propanediol, hydrogen peroxide and their combinations.

[0180] In some embodiments, any one of the components is essentially free, or free, or devoid of one or more ingredients selected from the group consisting of silicones, including silicone oils, sulfates and their combinations.

[0181] Although the optional components mentioned above are given by way of example, it will be understood that other optional components compatible with cosmetic applications known in the art may be used.

[0182] According to the various embodiments, the number of additives present in the skin enhancement system can range from about 0 to about 50%, from about 0.5 to about 30%, from about 1.5 to about 20% and from about 5 to about 15%, or any appropriate combination, sub-combination, range or sub-range of these by weight, based on the weight of the oxidizing component or the chemical peeling component of the skin enhancement system.

[0183] In certain embodiments, one or more additives, alone or in combination, may be present in one or both of the oxidizing component and the chemical peeling component of the skin enhancement system from about 0.05 to about 50% by weight, from about 0.05% to about 2.5% by weight, from about 0.1% to about 2%, from about 0.25% to about 1.5% and from about 0.5% to about 1.25%, or any appropriate combination, subcombination, range or subrange of these by weight, based on the weight of the oxidizing component or the chemical peeling component of the skin enhancement system.

[0184] In certain embodiments, one or more other additives, such as preservatives, vitamins and the like, alone or in combination, may be present in one or both of the oxidizing component and the chemical peeling component of the skin enhancement system from about 0.05 to about 50%. weight, from about 0.05% to about 25% by weight, from about 0.1% to about 10%, from about 0.25% to about 5% and from about 0.5% to about 3.5%, or any appropriate combination, sub-combination, range or sub-range of these by weight, based on the weight of the oxidizing component or chemical peeling component of the skin enhancement system.

[0185] Thus, one or a combination of optional additives may be present in one or both components, oxidant and chemical peel, of the skin improvement system, by weight, based on the weight of the oxidant component or the chemical peel component of the product, skin improvement system, each or the combination present of approximately 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 at approximately 50 percent by weight, including increments and ranges between and between these. MANUFACTURING ITEMS

[0186] According to the various embodiments, the skin enhancement system may be supplied in a kit or other manufactured article.

[0187] In various embodiments, the invention relates to a manufacturing article for the skin improvement system comprising at least a first and a second composition contained separately, the first composition comprising an oxidizing component, comprising at least one oxidizing agent and water, and the second composition comprising a chemical peeling component comprising at least one hydroxy acid and water, wherein the first and second compositions are contained for separate dispensing for application to the skin, in any order, and the skin improvement system being usable according to any one of a number of possible application cycles of the skin improvement protocol, the oxidizing component being used therein in conjunction with the chemical peeling component, applied sequentially, once or more frequently,with applications of at least one of the components on a daily basis for a few days or several days.

[0188] In some embodiments, each of the oxidizing component and the chemical peeling component is supplied in a form with or without rinsing and is selected from the group consisting of a suspension, an emulsion cream, a serum, an essence, a gel and a tonic.

[0189] In some embodiments, the manufactured article comprises the first and second compositions, each contained separately in a single-use container.

[0190] In some embodiments, the manufactured article comprises the first and second compositions, each contained separately in a multi-use container.

[0191] In some embodiments, the manufactured article comprises the first and second compositions, each contained separately as unique units in a plurality of single-use containers.

[0192] In some embodiments, each of the first and second compositions is contained in the form of a mask, liquid, stick, spray, ointment, paste, foam, scum, shaving cream, wipe, patch, strip or film-forming product.

[0193] In some embodiments, the first composition is an oxidizing component contained for application as a rinse-off mask, and the second composition is a chemical peeling component contained for application as a leave-on cream.

[0194] In some embodiments disclosed herein, the skin care formulation may be disposed in a first compartment of a sachet and the application surface may be a surface of a second compartment of the sachet, and wherein the first compartment and the second compartment are fluidly separated by a breakable barrier.

[0195] In some embodiments described herein, a component of the skin-enhancing system can be coupled to an application surface of an applicator. In some embodiments disclosed herein, the application surface can be a surface of a mask configured to conform to the wearer's face. In some embodiments disclosed herein, the application surface can be selected from the group consisting of a bristle surface of a brush, a roller surface of a rolling applicator, and a blade surface of a spatula.

[0196] It will be appreciated that in the various embodiments of the conditioning, the sub-compositions which are conditioned are kept separate until the composition is intended to be applied to the keratinous tissues.

[0197] In one embodiment, the manufactured article may be a package with separate compartments or chambers, separated by a breakable, hermetic seal between the chambers. During use, the seal is broken by the user to make contact with the separately packaged sub-components and dispense them for application to the skin. In still other embodiments, the manufactured article may be a double-chamber tube. In yet other embodiments, the manufactured article may be a double-chamber pump. In some other embodiments, the packaging for one or both components may be a single container containing a suspension of encapsulated material that is shaken / broken to disperse and mix. And in still other embodiments, the packaging is, moreover, sufficient to retain each of the components until it is intended to be applied to the keratin tissue.

[0198] In some embodiments, one or both of the first and second parts may be delivered by application by spraying, or by another applicator chosen from a pump or a brush.

[0199] According to the different embodiments, a component of the skin improvement system can be adapted for direct application, or for the formation of a mask, from a form which is a suspension, a lotion, a cream, a serum, an essence, a gel, a stick, a spray, an ointment, a paste, a mousse, a cream, a wipe, a patch, a strip, a film-forming product.

[0200] METHODS AND PROTOCOLS FOR PROVIDING SKIN-SMOOTHING BENEFITS

[0201] The invention also proposes, in various embodiments, a protocol for improving the skin using oxidizing application components and acids, comprising applying to a skin area, excluding the skin around the eyes, (a) a first composition comprising an oxidizing component that includes an oxidizing agent and water; and (b) a second composition comprising a chemical peeling component that includes one or a combination of hydroxy acids and water, the first and second compositions being applied sequentially, in any order. In some embodiments, the oxidizing component is applied first, followed by the chemical peeling component, and in other embodiments, the chemical peeling component is applied first, followed by the oxidizing component.

[0202] In some embodiments, the steps of the protocol further include (c) rinsing the skin after application of at least one of the first and second compositions, and include (a), (b) and (c) in any order, step (c) being able to be repeated.

[0203] The protocol can be chosen from one or a combination of application cycles.

[0204] In some embodiments, after a first instance of step (a), step (b) is repeated once a day, over a plurality of days.

[0205] In some embodiments, step (a) is repeated once every third, fourth or fifth day and step (b) is skipped on the days when step (a) is repeated.

[0206] In one embodiment of a protocol cycle, after a first instance of step (a), step (b) is repeated once a day, over a plurality of days. For example, in a particular embodiment, on day 1, the oxidizing component is applied first, followed by the chemical peeling component, and then, on at least one or more subsequent days, the chemical peeling component is applied daily.

[0207] In one embodiment of a protocol cycle, step (a) is repeated once every third, fourth, or fifth day, and step (b) is skipped on the days when step (a) is repeated. For example, in a first embodiment of a protocol cycle, on day 1, the oxidizing component is applied first, followed by the chemical peeling component; then, on days 2, 3, and 4, the chemical peeling component is applied daily; on day 5, the oxidizing component is applied followed by the chemical peeling component; and then, on days 6 and 7, the chemical peeling cream is applied. And, for example, in a second embodiment of a protocol cycle, on day 1, the oxidizing component is applied first, possibly followed by the chemical peeling component; and then, on days 2–7, the chemical peeling component is applied daily.And, for example, in a third embodiment of a protocol cycle, on day 1, the oxidizing component is applied first, and then, on days 2, 3 and 4, the chemical peeling component is applied each day, and on day 5 the oxidizing component is applied, then on days 6 and 7, the chemical peeling cream is applied.

[0208] Other protocol cycles are possible and the preceding examples are not limiting.

[0209] In some embodiments, the protocol is practiced for at least one day.

[0210] In some embodiments, the protocol is performed for at least three days, with at least one application of at least one component each day. In some embodiments, the protocol is performed for at least three days or more, with at least one application of at least one component during the time period, although one or more days may not include the application of a component.

[0211] In some embodiments, the protocol is performed for at least 28 days, with at least one application of at least one component each day. In some embodiments, the protocol is performed for at least 28 days, with at least one application of at least one component during the time period, although one or more days may not include the application of any component.

[0212] In some embodiments, a component of the skin enhancement system is applied to keratinous tissue, for example, body or facial skin, in some particular embodiments to the face and generally excluding the eye contour, at a temperature of about 15°C to about 30°C, or about 20°C to about 25°C.

[0213] The skin enhancement system is suitable for home use or home application. As such, a component of the skin enhancement system according to the present invention is applied by a non-professional or is self-applied in a non-clinical environment.

[0214] A component of the skin improvement system can be applied in any manner, for example, by spreading, spraying, wiping, dispensing, etc. (hereinafter "application") onto the keratinous tissue. This can generally be accomplished with, for example, a spray bottle, an absorbent cotton swab moistened with the concentrated solution, a moistened sable brush, or by gently wiping with a moistened absorbent fibrous material, such as a square of gauze or a non-woven pad, but other techniques for applying the solution that coat the skin uniformly are also possible.

[0215] A component of the skin improvement system intended for application without rinsing is applied and left to air dry without being removed until the user performs their usual cleansing routine. Of course, a component of the skin improvement system may optionally be removed after application and a selected time interval, although the results may not be as desirable. Drying may be aided by directing a gentle stream of air, warm air, over the treated area or by other similar procedures. A single, even application of a component of the skin improvement system to the keratinous tissue is generally sufficient.Additional or multiple applications before or immediately after the applied solution has dried are normally unnecessary but may be helpful in certain situations, for example, when applying to keratinous tissues on parts of the body other than the face, or when applying to keratinous tissues that are in strong need of exfoliation. For rinse-off forms of a skin-enhancing system component, the component must be rinsed off, especially before applying any other composition or product to the skin. EXAMPLE 1: Raw materials

[0216] The percentages of each ingredient, as they may be illustrated in the following examples, are indicated as the quantity of active ingredient, the raw materials being able to be present in an amount equal to the quantity of active ingredient, or if the raw material has a concentration of active ingredient which is less than 100%, then the composition comprises the raw material which includes an active ingredient and a suitable solvent, the concentration of active ingredient in the raw material being indicated below.

[0217] The following raw materials for the ingredients, as indicated in the TABLES below, comprise active ingredients present at less than 100%, as follows:

[0218] [Table 1] Representative raw materials Active percentage Raw material Percentage of active ingredients (%) Hydrogen peroxide 50 Pentasodium tetramethylenediamine phosphonate 33 Tetrasodium glutamate diacetate 47.5 Phosphoric acid 85 Stearic acid 53 Trisodium ethylenediamine disuccinate 37 Hydroxyethyl acrylate / acryloyldimethyl taurate copolymer Sodium 90 Lactic acid 90 Dicaprylyl ether 99.97 Glycolic acid 70 EXAMPLE 2: Inventive compositions

[0219] Oxidizing component

[0220] [Table 2] Oxidizing component. Embodiments in cream form (as a creamy cleansing emulsion to be rinsed off) INGREDIENT: OXIDIZED CREAM BASE. OXIDIZING CREAM TE A OXIDIZING CREAM EB OXIDIZING CREAM C 50% oil 20% oil 50% oil STEARETH-2 3.5 3.50 3.50 1.75 STEARETH-20 1.5 1.50 1.50 0.75 HYDROGEN PEROXIDE 4.0 4.00 4.00 4.00 C15-19 ALKANE 50.00 50.00 20.00 50.00 SCLEROTIC GUM 1.0 1.00 1.00 1.00 ETHYLENEDIAMINE TETRAMETHYLENE PENTASODIUM PHOSPHONATE 0.3 GLUTAMATE DIACETATE TE- 0.15 0.15 0.15 TRASODIUM OTHER INGREDIENTS (PHOSPHORIC ACID, SODIUM PHOSPHATE, TE-TRASODIUM PYROPHOSPHATE, TOCOPHEROL, SODIUM SALICYLATE) 0.7 0.6 0.6 0.6 WATER qs qs qs qs

[0221] [Table 3] Embodiments of tonic with an oxidizing component (in the form of a leave-on tonic) OXIDIZING TONIC INGREDIENT (% by weight) Hydrogen peroxide 4 Water 96

[0222] Chemical peeling component: Forms: Emulsion, Cream and Liquid

[0223] [Table 4] Embodiments of peeling component cream (in the form (of a leave-in moisturizer in a creamy emulsion) INGREDIENT BASE PEELING MOISTURIZING PEELING MOISTURIZING 1 PEELING MOISTURIZING 2 PEELING MOISTURIZING 3 10% Glycerin 5% Glycerin 7% Glycerin GLYCERIN 10.00 10.00 5.00 7.00 GLYCOLIC ACID 14.28 14.28 14.28 14.28 SALICYLIC ACID 0.45 0.45 0.45 0.45 C12-15 ALKYL BENZOATE 4.00 4.00 4.00 4.00 CAPRYLIC / CAPRIQUE TRIGLYCERIDE 5.00 5.00 5.00 5.00 CACAO (COCOA) SEED BUTTER (COCOA) THEOBROMA 1.00 1.00 1.00 1.00 BUTYROSPERMUM PARKII (SHEA) BUTTER 2.00 2.00 2.00 2.00 COCONUT CAPRYLATE / CAPRATE 3.00 3.00 3.00 3.00 GLYCERYL STEARATE 2.00 2.00 2.00 2.00 CETEARYL ALCOHOL (and) CETEARETH-20 1.00 1.00 1.00 1.00 Glyceryl Stearate (and) PEG-100 Stearate 2.00 2.00 2.00 2.00 Stearic Acid 1.00 1.00 1.00 1.00 Polysorbate 20 2.00 2.00 2.00 2.00 Sodium Hydroxide 4.5 2.25 2.25 2.25 Xanthan Gum 0.20 0.20 0.20 0.20 Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer 4.00 4.00 4.00 4.00 WATER qs qs qs qs OTHER INGREDIENTS (PHENOXYETHANOL, ETHYLENEDIAMIN ETRISODIUM DISUCCINATE, TO-COPHEROL, CHLOR-PHENESINE) 1.40 1.40 1.40 1.40

[0224] [Table 5] Embodiments of a toner with a peeling component (in the form of a leave-on toner) INGREDIENTS PEELING TONIC 1 (MODIFIED JESSNER-TYPE HOME PEEL) PEELING TONIC 2 POTASSIUM HYDROXIDE 2.00 LACTIC ACID 11.11 SALICYLIC ACID 0.45 PHENYLETHYL RESORCINOL 0.75 DENATURED ALCOHOL 10.69 WATER 75.00 LACTIC ACID 4.20 SALICYLIC ACID 0.20 BETAINE 0.93 SODIUM CHLORIDE 0.93 DICAPRYLYL ETHER 1.86 MACADAMIA TERNIFOLIA SEED OIL 0.47 SQUALANE 4.64 GLYCERIN 4.65 PROPANEDIOL 2.79 PENTYLENE GLYCOL 3.72 CARRAGENINE 0.093 SODIUM HYALURONATE 0.0093 SODIUM HYDROXIDE 1.32 FRAGRANCE 0.029 WATER 74.15

[0225] The skin-enhancing system of the invention is used by employing any combination of an oxidizing component and a chemical peeling component, such as, in particular, a selection from the examples provided in the tables above. Table 6 below provides a list of inventions that are combinations of formulations of oxidizing components and chemical peeling components from the tables above, as well as comparative compositions that include oxidizing or chemical peeling components alone, from which the examples in Table 6 are selected for use in the test studies presented in the examples below. As used herein, the term "Peeling Moisturizer" refers to moisturizing forms of the chemical peeling component, for example, but not limited to, creamy emulsion forms thereof.

[0226] [Table 6] Inventive and comparative test compositions (the compositions of the inventive system include the specified oxidizing and peeling chemical components which are used individually for comparisons in the examples as specified comparative compositions) Part A Part B TEST EXAMPLE INGREDIENTS USED IN THE EXAMPLE BELOW OXIDIZING COMPONENT CHEMICAL PEELING COMPONENT Control acid 70% glycolic acid Examples 3 and 4 N / AN / A Comp 1 Peroxide; 50% oil Examples 3, 4 and 6 CREAM BASE OXID. Compound 2 Acids; high oil content Examples 3, 4 and 6 N / A MOISTURIZING PEELING BASE Compound 3 (Jessner type) Acids; nominal oil content Example 3 N / A PEELING TONIC 1 (Jessner type) Compound 4 Acids; high oil content Example 4 N / A PEELING MOISTURIZING 1 Compound 5 Peroxide; nominal oil content Example 4 OXIDIZING TONIC INVENTIVE 1 Examples 3, 4 and 6 OXIDIZING CREAM BASE MOISTURIZING PEELING BASE INVENTIVE 2 Example 3 OXIDIZING CREAM BASE PEELING TONIC 1 (Jessner type) INVENTIVE 3 Example 4 OXIDIZING TONIC MOISTURIZING PEELING 1

[0227] EXAMPLE 3: In vitro test of the stratum corneum for lipid disorganization with cream and toner forms of the chemical peeling component

[0228] In vitro tests on the stratum corneum (SC) were performed to evaluate lipid disorganization, and the AT was determined using differential scanning calorimetry (DSC), measuring the heat change associated with thermal denaturation under constant heating conditions. The compositions and control samples were applied to an in vitro stratum corneum surface (~0.1 g / sample) for 15 min at 75% relative humidity. Depending on the application, which included the use of oxidizing components followed by chemical peeling components, the applications were performed sequentially (i.e., not simultaneously / in parallel). After single or sequential applications, the stratum corneum surface was cleaned and rinsed with distilled water and left to dry overnight at 75% relative humidity. The DSC profile was measured from 20°C to 120°C at 5°C / min to provide AT for lipid-related peaks at 70-75 C and 80-85 C.AT is calculated by the change in peak temperature by comparing the temperature of the untreated control to the compositions as listed in TABLE 7 below. The results are presented in TABLE 7 and in [Fig. 1]. Composition Ingredients AT Control Acid 70% Glycolic Acid -9.968 + / - 0.47 Comp 1 Peroxide; 50% Oil -3.823 + / - 1.33 Comp 2 Acids; High Oil -5.99367 + / - 1.11 INVENTIVE 1 Comp 1 (OXIDIZED CREAM BASE) followed by Comp 2 (PEELING HYDRATORY BASE) -13.8335 + / - 1.54 Comp 3 Acids; Nominal Oil -6.6205 + / - 0.57 INVENTIVE 2 Comp 1 (OXIDIZED CREAM BASE) followed by Comp 3 (PEELING TONIC 1) -14.345 + / - 1.51

[0229] [Table 7] Lipid disorganization: Oxidizing component (in emulsion cream form) with chemical peeling component of creamy moisturizer and leave-on toner forms.

[0230] With reference to TABLE 7, the study demonstrates the synergistic effect on skin rejuvenation in a stratum corneum model when a rinse-off form of the oxidizing component is used with a leave-on moisturizing emulsion or with a chemical peeling tonic component.

[0231] EXAMPLE 4: In vitro test of the stratum corneum for lipid disorganization with cream and tonic forms of oxidizing component

[0232] In vitro tests on the stratum corneum to evaluate lipid disorganization were performed as described above. Studies were conducted with each of the test compositions as listed in TABLE 8, to evaluate the effect of the compositions on the stratum corneum. The results are presented in TABLE 8 and [Fig. 2].

[0233] [Table 8] Lipid disorganization: Tonic form of the oxidizing component with emulsion form of the chemical peeling component (moisturizer) Composition Ingredients AT Control Acid 70% Glycolic Acid -8.60 + / - 0.08 Comp 4 Acids; high oil -1.49 + / - 0.66 Comp 5 Peroxide; nominal oil -0.11 + / - 0.29 INVENTIVE 3 Comp 5 (OXIDIZING TONIC) followed by Comp 4 (PEELING MOISTURIZER) -4.13 + / - 0.24 1)

[0234] With reference to TABLE 8, the study demonstrates the synergistic effect on skin rejuvenation in a stratum corneum model when a tonic form of the oxidizing component is used with a moisturizing chemical peeling component in a leave-on emulsion.

[0235] The results presented in this Example 4, combined with the results of Example 3, demonstrate that a consistently higher level of lipid disorganization is observed in the stratum corneum treated with the protocol that includes the use of a skin-enhancing system comprising a single application of an oxidizing component containing hydrogen peroxide followed by a single application of a chemical peeling component, regardless of the formulation forms. In particular, the data clearly show that there is a synergistic (i.e., greater than additive) skin-rejuvenating effect, as evidenced by the lipid disorganization, when different combinations of rinse-off and non-rinse-off forms of the oxidizing component and the chemical peeling components are used. EXAMPLE 5: Ex vivo skin study

[0236] Compositions including Acid Control, Comp 1, Comp 3 and INVENTIVE 2 were evaluated in an ex vivo study to show biological effects on skin samples.

[0237] Fresh samples of normal post-abdominoplasty human skin were collected, defatted, and cleaned. Excipients were prepared using a 12 mm biopsy punch. Three punches were produced for each application condition at two different time points: Day 1 and Day 7. Before culturing the skin tissue, the biopsies were treated with different applications according to the following procedure:

[0238] Comp 1 (OXIDIZING CREAM BASE): 50 µl of part A and 50 µl of part B were applied for 15 minutes. After application, the formula was removed and the sample surfaces were cleaned and dried before being recultured.

[0239] Comp 3 (PEELING TONIC 1):

[0240] A sterile cotton-tipped applicator was soaked in modified Jessner Home Peel and the formula was applied topically to ex vivo skin samples for 10 minutes. After application, the expiant surfaces were cleaned and dried before re-culture.

[0241] INVENTIVE 2 (OXIDIZING CREAM BASE followed by TONIC) PEELING 1): 50 µl of part A and 50 µl of part B were applied for 15 minutes. After application, the formula was removed and the sample surfaces were cleaned and dried before being recultured.

[0242] All ex vivo skin expiants were cultured at the air-liquid interface in Dulbecco's Modified Eagle Medium (DMEM with 10% fetal bovine serum and 1% penicillin-streptomycin) at 37°C. On days 1 and 7, the samples were split and placed in formalin and OCT gel for hematoxylin and eosin (H&E) immunofluorescence staining and frozen sectioning, respectively. Involucrine immunofluorescence staining was performed by first fixing frozen section samples for 10 minutes at -20°C in methanol. The slides were then permeabilized with 0.1% Triton-X in PBS. The samples were blocked with 10% normal goat serum for one hour at room temperature. Tissue sections were then incubated with rinvolucrine polyclonal rabbit (Abcam, ab81468, 1:150) for one hour.The slides were then incubated with the secondary antibody using Goat Anti-Rabbit IgG H&L Alexa Fluor 594 in a 1 / 200 dilution in a blocking solution and counterstained with DAPI. All sections were then imaged using a fluorescence microscope (Leica DM500, Wetzlar, Germany).

[0243] All samples were examined without and with involucrine, which is a key biomarker indicating the kinetics of skin renewal.

[0244] Referring now to the drawings, [Fig. 3] represents microscopic examination images of the samples tested on day 1 (reference) for H&E (A = acid control, B = Comp 3, C = Comp 1 and D = INVENTIVE 2) and on day 7 for H&E and involucrine staining (E = acid control, F = Comp 3, G = Comp 1 and H = INVENTIVE 2). Further analysis of involucrine expression at J7, as also shown in [Fig. 3], suggests that the INVENTIVE 2 formulation as described had an increased effect compared to Comp 1 and Comp 3 used alone, in which, without being bound by theory, it is envisaged that the inventive application results in an increase in the level of involucrine greater than the level observed for each of the comparators alone.This suggests that the inventive application with the INVENTIVE 2 formulation as described has the potential to synergistically stimulate skin barrier renewal when considered with the stratum corneum data from previous examples. EXAMPLE 6: Clinical Study

[0245] In the study, one application regimen consisted of twice-weekly application of an oxidizing component in the form of a rinse-off mask, followed by daily application of a chemical peeling component in the form of a leave-on moisturizing cream, and was compared to a regimen consisting of daily application of a moisturizing chemical peeling component alone (without any oxidizing component). The compositions used were Comp 4 (PEELING MOISTURIZING 1) and INVENTIVE 3 (Comp 5 (OXIDIZING TONIC) followed by Comp 4 (PEELING MOISTURIZING 1)).

[0246] Figure 4 illustrates the effects of the system of the invention on skin radiance reflection, Figure 5 illustrates the effects of the system of the invention on the appearance of pores, Figure 6 illustrates the effects of the system of the invention on visual smoothness, Figure 7 illustrates the effects of the system of the invention on fine lines, and Figure 8 illustrates the effects of the system of the invention on wrinkles. The results of following the illustrated inventive protocol over a period ranging from a few days to 28 days demonstrated a rapid and statistically significant improvement in skin radiance within one day, an improvement in the appearance of pores and visual smoothness within three days, an improvement in facial fine lines within fourteen days, and an improvement in facial wrinkles within twenty-eight days.The results show that the system and protocol of the invention resulted in a statistically significant improvement in skin radiance and overall facial fine lines compared to the use of the hydrating peel alone. These results, as shown in Example 5, are consistent with the in vitro results described in Examples 3-5.

[0247] The articles "a" and "an," as used herein, mean one or more when applied to any feature in the embodiments of the present invention described in the description and claims. The use of "a" and "an" does not limit the meaning to a single feature unless such a limitation is specifically indicated. The articles "the" or "the" preceding singular or plural nouns or noun phrases denote a particular specified feature or particular specified features and may have a singular or plural connotation depending on the context in which it is used. The adjective "all" means one, some, or all without distinction of quantity whatsoever.

[0248] “At least one”, as used here, means one or more and thus includes individual components as well as mixtures / combinations.

[0249] The transitional terms “comprising,” “essentially consisting of,” and “consisting of,” when used in the appended claims, in their original and amended forms, define the scope of the claim with respect to any additional unlisted claim elements or steps, if any, which are excluded from the scope of the claim(s). The term “comprising” is intended to be inclusive or open and does not exclude any additional unlisted element, method, step, or material. The term “consisting of” excludes any element, step, or material other than those specified in the claim and, in the latter case, ordinary impurities associated with the specified material(s). The term “essentially consisting of” limits the scope of a claim to the specified elements, steps, or materials and to those which do not materially affect the characteristics fundamental and novel risks of the claimed invention. All the materials and processes described herein that embody the present invention can, in other embodiments, be more specifically defined by one of the transitional terms "comprising", "essentially made of" and "made of".

[0250] Except in the operational examples, or where otherwise indicated, all numbers expressing quantities of ingredients and / or reaction conditions shall be understood as being modified in all cases by the term "approximately", meaning to within 10% of the number indicated (e.g., "approximately 10%" means 9% - 11% and "approximately 2%" means 1.8% - 2.2%).

[0251] All percentages and ratios are, unless otherwise stated, calculated by weight. All percentages are, unless otherwise stated, calculated on the basis of the total composition. In general, unless expressly stated otherwise herein, "weight" or "quantity," as used herein in relation to the percentage of an ingredient, refers to the quantity of raw material comprising the ingredient, the raw material being described herein as comprising less than and up to 100% of the ingredient's activity. Therefore, the percentage by weight of an active ingredient in a composition is represented as the quantity of raw material containing the active ingredient that is used and may or may not reflect the final percentage of the active ingredient, the final percentage of the active ingredient being dependent on the percentage by weight of the active ingredient in the raw material.

[0252] All ranges and quantities given herein are intended to include subranges and quantities using any disclosed point as an endpoint. Thus, a range of "1% to 10%, such as 2% to 8%, such as 3% to 5%", is intended to encompass ranges of "1% to 8%", "1% to 5%", "2% to 10%", and so on. All numbers, quantities, ranges, etc., are intended to be modified by the term "approximately", whether or not expressly stated. Similarly, a given range of "approximately 1% to 10%" is intended to have the term "approximately" modifying both the 1% and 10% endpoints. Furthermore, it is understood that where a quantity of a component is given, it is intended, unless specifically stated otherwise, to mean the quantity of active material.

[0253] Notwithstanding the fact that the numerical ranges and parameters defining the broad scope of disclosure are approximations, unless otherwise indicated, the numerical values ​​shown in the specific examples are reported as accurately as possible. However, every numerical value inherently contains some errors necessarily resulting from the standard deviation found in their respective test measurements. The following example serves to illustrate embodiments of the present invention without being limiting in nature.

[0254] Although the invention has been described with reference to a preferred embodiment, those skilled in the art will understand that various changes can be made and that Equivalents may be substituted for elements thereof without departing from the scope of the invention. Furthermore, numerous modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from its essential scope. Therefore, it is understood that the invention is not limited to the particular embodiment disclosed as the best envisaged means of implementing this invention, but that the invention shall include all embodiments falling within the scope of the appended claims.

Claims

Demands

1. A manufactured article for the skin improvement system comprising: at least a first and a second composition contained separately, (a) the first composition comprising an oxidizing component selected from the group consisting of: (i) at least one oxidizing agent comprising hydrogen peroxide, optionally one or more agents selected from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and combinations thereof, and water, in which the oxidizing component is formulated in tonic form; and (ii) at least one oxidizing agent comprising hydrogen peroxide, optionally one or more agents selected from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and combinations thereof; one or a combination of surfactants comprising steareth-2 and steareth-20; one or more polymers comprising sclerotium gum; one or more vitamin actives, preservatives or combinations thereof and water present in an amount of about 35% to about 75%, by weight, based on the weight of the oxidizing component, the oxidizing component being formulated as a creamy emulsion, and (b) the second composition comprising a chemical peeling component selected from the group consisting of: (i) a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid; one or a combination of oils comprising squalane and nut oils; one or a combination of surfactants; one or more thickeners; one or more water-based solvents comprising glycerin; one or more active vitamins, preservatives, chelating agents, pH adjusters, or combinations thereof and water present in an amount of approximately 40% to approximately 50%, by weight, based on the weight of the skin-peel component, the chemical peel component being formulated as a creamy emulsion; and (ii) a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid; a or a com

2. combination of vegetable oils or butters; one or a combination of surfactants including betaine; one or more thickeners including carrageenan; one or more water-based solvents including glycerin or propanediol; one or more active ingredients including hyaluronic acid, perfumes, preservatives, chelating agents, pH adjusters, or combinations thereof;and water present in an amount of about 40% to about 50%, by weight, based on the weight of the skin peeling component, wherein the chemical peeling component is formulated as a tonic, wherein the first and second compositions are contained to be dispensed separately for application to the skin, in any order, and the skin enhancement system being usable according to any of a number of possible application protocols in which the oxidizing component is used in conjunction with the chemical peeling component, applied sequentially, once or more frequently, with applications of at least one of the components on a daily basis for a few days or several days. A protocol for improving the skin, including: (a) The provision of a first composition comprising an oxidizing composition selected from the group consisting of: (i) at least one oxidizing agent comprising hydrogen peroxide, optionally one or more agents selected from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and combinations thereof, and water, the oxidizing component being formulated as a tonic; and (ii) at least one oxidizing agent comprising hydrogen peroxide, optionally one or more agents selected from the group consisting of tetrasodium glutamate diacetate, tetrasodium phosphate, phosphoric acid, sodium phosphate and combinations thereof; one or a combination of surfactants comprising steareth-2 and steareth-20; one or more polymers comprising sclerotium gum; one or more vitamin actives, preservatives or combinations thereof and water present in an amount of about 35% to about 75%, by weight, based on the weight of the oxidizing component, the oxidizing component being formulated as a creamy emulsion; and (b) The supply of a second composition comprising a chemical peeling component selected from the group consisting of: (i) a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid; one or a combination of oils comprising squalane and nut oils; one or a combination of surfactants; one or more thickeners; one or more water-based solvents comprising glycerin; one or more active vitamins, preservatives, chelating agents, pH adjusters, or combinations thereof and water present in an amount of about 40% to about 50%, by weight, based on the weight of the dermal peeling component, the chemical peeling component being formulated as a creamy emulsion; and (ii) a hydroxy acid comprising lactic acid and at least one beta-hydroxy acid comprising salicylic acid; one or a combination of vegetable oils or butters;one or a combination of surfactants including betaine; one or more thickeners including carrageenan; one or more water-based solvents including glycerin or propanediol; one or more active ingredients including hyaluronic acid, perfumes, preservatives, chelating agents, pH adjusters, or combinations thereof and water present in an amount of approximately 40% to approximately 50%, by weight, based on the weight of the skin peeling component, in which the chemical peeling component is formulated as a tonic, (c) The application of the first composition to an area of ​​skin excluding the skin around the eye; (d) The application of the second composition to an area of ​​skin excluding the skin around the eye; the first and second compositions being applied sequentially, in any order.

3. Protocol according to claim 2, wherein the steps of the protocol further include (e) rinsing the skin after application of at least one of the first and second compositions, and include (c), (d) and (e) in any order, and wherein step (e) may be repeated.

4. Protocol according to claim 2 or 3, wherein after a first example of the step of applying the first composition, the step of applying the second composition is repeated once a day, over a plurality of days.

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