Concentrate comprising a semiochemical composition

Abstract

The invention relates to the field of semiochemical products, and describes in particular a composition in the form of a concentrate of these products which can be diluted in water, comprising a semiochemical composition, in particular a lipophilic and water-dispersible semiochemical composition, as well as its preparation process. The invention also relates to the non-therapeutic use of the diluted composition according to the invention for topical administration, in particular cutaneous administration to an animal or a human.

Description

Title of the invention: Concentrate comprising a semiochemical composition Technical field of the invention

[0001] The invention relates to the field of semiochemical products, and describes in particular a composition in the form of a concentrate of these products which can be diluted in water, comprising a semiochemical composition, in particular a lipophilic and water-dispersible semiochemical composition, as well as its preparation process. The invention also relates to the non-therapeutic use of the diluted composition according to the invention for topical administration, in particular cutaneous administration to an animal or a human. State of the prior art

[0002] The semiochemicals according to the invention correspond to mixtures of several chemical compounds, described for the first time in particular by Silverstein, RM (1977). Semiochemicals are chemical substances emitted by a plant or an animal which provoke a non-therapeutic behavioral or physiological reaction in another organism. When the semiochemical product affects an individual of the same species (an "intraspecific" semiochemical product), it is called a pheromone (Wyatt TD, 2003). There are several types of pheromones allowing different types of behavioral interactions or communication, for example appeasing pheromones, sex pheromones, territorial marking pheromones and alert pheromones. When the semiochemical product affects an individual of a different species (an "interspecific" semiochemical product), it is called an allelochemical substance.Among allelochemicals, an allomone is an allelochemical that triggers a reaction in the target species, this reaction being favorable to the species that releases the allomone (the opposite is a kairomone).

[0003] Since 1995, specialties whose active ingredients are semiochemical agents have been placed on the market. Some of their uses require the product to be deposited on the animal's skin, for example to achieve the desired effects on an animal in an open environment or to protect it against pests such as parasites or biting insects, or on human skin. The physicochemical constraints of the semiochemical components, and in particular their volatility and insolubility in water, have led to the use of excipients such as ethoxydiglycol in marketed specialties. The use of this type of excipient is now increasingly limited by the regulations in force, but also by the general public who tend to reject them because of their synthesis methods and their potential direct and environmental toxicity. It therefore appeared necessary to develop aqueous formulations of semiochemical compounds in different galenic forms. Presentation of the invention

[0004] The invention aims to develop a composition based on semiochemical products (also called compounds, active ingredients or agents) in a concentrated form allowing the preparation of a new galenic form, preferably non-toxic and environmentally friendly, in particular a composition in the form of a concentrate diluted in water, comprising a semiochemical composition. A composition in the form of a concentrate allows in particular an end user to obtain a ready-to-use composition following the performance of a dilution step, in particular a dilution of the concentrate in water.This dilution is easy to carry out and can be carried out on site, before or at the time of use, preferably extemporaneously, according to final quantities and concentrations desired by the end user, thus reducing the weight of the composition in the form of a concentrate distributed and the volume of water, in particular large quantities of water, for transport, and allowing use on large surfaces, for example livestock buildings. The composition in the form of a concentrate has in particular a long shelf life (at least 2 years). A non-therapeutic use of said composition in the form of a concentrate, after dilution, relates to a topical, in particular cutaneous administration of the composition to an animal, in particular poultry such as hens, in particular on the skin of poultry such as hens, in particular to prevent infestation by parasites such as the red poultry mite (Dermanyssus sp.or Omithonyssus sylviarum). Another non-therapeutic use of said composition in the form of a concentrate, after dilution, relates to a topical, in particular cutaneous administration of the composition to an animal, for example birds or mammals, in particular on the skin of birds or mammals, or to a human, in particular on human skin, in particular to prevent infestation or bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks. Summary of the invention

[0005] The invention is defined by the independent claims. The dependent claims define particular or preferred embodiments of the invention.

[0006] According to a first aspect, the invention relates to a composition in the form of a concentrate which can be diluted in water, comprising: (a) at least one ester of fatty acid and polyoxyethylene sorbitan; b) a lipophilic and water-dispersible semiochemical composition, in particular a semiochemical composition comprising bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate in a content at least equal to 40% by weight of the composition in the form of a concentrate, the total sum of the compounds present in the composition in the form of a concentrate being equal to 100%.

[0007] According to a second aspect, the invention relates to a process for preparing a composition in the form of a concentrate according to the invention, comprising the following steps: a) mixing the semiochemical composition, said at least one fatty acid ester and polyoxyethylene sorbitan and optionally said at least one additive, with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous mixture; b) optionally add a perfume; c) the composition obtained in step a) or b) is recovered in the form of a concentrate.

[0008] According to a third aspect, the invention relates to the non-therapeutic use of a composition diluted in water according to the invention for topical administration, in particular cutaneous administration to poultry such as chickens, in particular on the skin of poultry such as chickens, in particular to prevent infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum); or for topical administration, in particular cutaneous administration to an animal, for example birds or mammals, in particular on the skin of birds or mammals, or to a human, in particular on human skin, in particular to prevent infestation or bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks. Detailed description of the invention

[0009] The invention is now described in more detail and in a non-limiting manner in the following description. Unless otherwise indicated (for example specific mention of v% / v%), all percentages relating to quantities are mass percentages. Any reference to ranges of values ​​in the description and / or the claims implies, unless otherwise stated, that the limits of the ranges are included.

[0010] The invention relates to a composition in the form of a concentrate which can be diluted in water, comprising: (a) at least one ester of fatty acid and polyoxyethylene sorbitan; b) a lipophilic and water-dispersible semiochemical composition, in particular a semiochemical composition comprising bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate in a content at least equal to 40% by weight of the composition in the form of a concentrate, the total sum of the compounds present in the composition in the form of a concentrate being equal to 100%.

[0011] In a particular embodiment of the invention, said semiochemical composition comprises from 40% to 60% by weight of bis(2-ethylhexyl) adipate and from 40% to 60% by weight of 1-isopropyl-2,2-dimethyltrimethylene diisobutyrate, the total sum of the compounds present in the semiochemical composition being equal to 100%.

[0012] In a preferred embodiment of the invention, said semiochemical composition comprises 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of 1-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

[0013] The composition according to the invention is in the form of a concentrate which can be diluted in water, in particular water supplied by the end user. In particular, the composition is in the form of a concentrate, in particular in the form of a homogeneous and liquid mixture, preferably in the form of a concentrate of yellow or brown color, and of medium viscosity.

[0014] In the context of the invention, the term "concentrate" or the expression "in the form of a concentrate" refers to a composition in the form of a concentrate which can be subject to further processing, in particular dilution, in particular in water, in order to obtain a so-called "ready-to-use" composition. The composition is said to be "in the form of a concentrate" to mean that its content of semiochemical composition is higher than the content of said semiochemical composition normally used in animals or in humans in a non-therapeutic application.

[0015] In a particular embodiment of the invention, said at least one ester of fatty acid and of polyoxyethylene sorbitan (also called ethoxylated sorbitan, sorbitan ester) includes in particular esters of fatty acid in C8-C24, preferably in C16-C22 and of polyoxyethylene sorbitan which may comprise from 1 to 150 oxyethylenated groups, such as for example polysorbate 20 in particular marketed under the name Tween 20® by the company CRODA, polysorbate 21 in particular marketed under the name Tween 21® by the company CRODA, polysorbate 40 in particular marketed under the name Tween 40® by the company CRODA, polysorbate 60 in particular marketed under the name Tween 60® by the company CRODA, polysorbate 61 in particular marketed under the name Tween 61® by the company CRODA, polysorbate 65, notably marketed under the name Tween 65® by the company CRODA, polysorbate 80, notably marketed under the name name Tween 80® by the company CRODA, polysorbate 81 marketed in particular under the name Tween 81® by the company CRODA and polysorbate 85 marketed in particular under the name Tween 85® by the company CRODA.

[0016] In a particular embodiment of the invention, the composition in the form of a concentrate comprises a single fatty acid ester of polyoxyethylene sorbitan, or a mixture of fatty acid esters of polyoxyethylene sorbitan as described above.

[0017] In a preferred embodiment of the invention, the composition in the form of a concentrate comprises a single ester of fatty acid and polyoxyethylene sorbitan, in particular polysorbate 85 (also called polyoxyethylene sorbitan trioleate) notably marketed under the name Tween 85® by the company CRODA.

[0018] In a particular embodiment of the invention, said at least one ester of fatty acid and of polyoxyethylene sorbitan is present in a content ranging from 25% to 60% by weight, preferably from 30% to 40% by weight, even more preferably from 34.90% or 35% by weight, relative to the total weight of the composition in the form of a concentrate.

[0019] The composition according to the invention further comprises a semiochemical composition as active agent, as defined above. A particular semiochemical composition is described above as well as in the preferred embodiments and experimental examples which follow. The semiochemical compositions contained in the compositions according to the invention are in particular intended for non-therapeutic use, for example use for their behavioral or protective effect against pests (parasites, insects, etc.) on the animals or humans to which they are administered or on the animals interacting with the latter, in the form of a composition diluted from the composition in the form of a concentrate according to the invention.

[0020] According to a particular embodiment, the semiochemical composition may be present in the composition in the form of a concentrate in a content ranging from 60% to 70% by weight, preferably 65% ​​by weight of semiochemical composition, relative to the total weight of the composition in the form of a concentrate.

[0021] The composition according to the invention may further comprise at least one additive provided that it does not interfere with the desired properties of the composition in the form of a concentrate.

[0022] In a particular embodiment of the invention, said at least one additive is chosen from the group consisting of a preservative agent, in particular an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

[0023] In the context of the invention, the term “preservative” refers to a agent protecting the composition according to the invention against the transformation of its physical or chemical state, its color, its odor or even protecting it from contamination or microbial degradation, for example by inhibiting the development of microorganisms during the storage or use time of the composition according to the invention. Such an agent must be compatible with use of the composition according to the invention in contact with an animal or a human, and is advantageously non-irritating to the skin and eyes.

[0024] Examples of preservatives are known to those skilled in the art and include in particular benzyl alcohol, didecyldimonium chloride, caprylyl glycol, phenylpropanol, sodium benzoate, phenyl acetate, sorbic acid, dehydroacetic acid, potassium sorbate, phenoxyethanol, cetrimonium bromide, triclosa, parabens, thiazolinones.

[0025] In the context of the invention, the term "antioxidant agent" refers to a preservative agent capable of inhibiting reactions promoted by oxygen, thus preventing oxidation.

[0026] Examples of antioxidant agents are known to those skilled in the art and include in particular cinnamic acids and their derivatives such as pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, notably marketed under the name Tinogard TT® by the company BASF, vitamin A (retinol) and derivatives, vitamin C (ascorbic acid) and derivatives (ascobate), vitamin E (tocopherol) and derivatives (tocopheryl), preferably Tinogard TT®.

[0027] The composition according to the invention may comprise from 0% to 2% by weight, preferably from 0.02% to 0.3% by weight, even more preferably 0.1% by weight of antioxidant agent, relative to the total weight of the composition.

[0028] In the context of the invention, the term "perfume" or perfuming agent refers to any hydrophobic substance designating a pure body or a mixture insoluble or very slightly soluble in water capable of releasing a pleasant odor.

[0029] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 1% or 2% by weight of perfume, relative to the total weight of the composition.

[0030] In the context of the invention, the term "masking agent" refers to an agent that reduces or inhibits the basic odor or taste of the product.

[0031] Examples of masking agents are known to those skilled in the art and include in particular beta sitosterol, citric acid, bisabolol, calendula officenalis flower extract.

[0032] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 1% or 2% by weight of a masking agent, relative to the total weight of the composition.

[0033] In a preferred embodiment of the invention, the composition in the form of a concentrate comprises: (a) polyoxyethylene sorbitan trioleate; (b) a semiochemical composition comprising bis(2-ethylhexyl) adipate and 1-isopropyl-2,2-dimethyltrimethylene diisobutyrate in a content of at least 40% by weight of the composition in concentrate form; and c) pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, the total sum of the compounds present in the composition in the form of a concentrate being equal to 100%.

[0034] In an even more preferred embodiment of the invention, the composition in the form of a concentrate comprises: a) from 25% to 60% by weight, preferably from 30% to 40% by weight, even more preferably from 34.9% or 35% by weight, expressed by weight relative to the total weight of the composition in the form of a concentrate, of polyoxyethylene sorbitan trioleate; b) from 60% to 70% by weight, preferably from 65% by weight, expressed by weight relative to the total weight of the composition in the form of a concentrate, of a semiochemical composition comprising bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, in particular from 40% to 60% by weight of bis(2-ethylhexyl) adipate and from 40% to 60% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, preferably 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; and c) from 0.02% to 0.3% by weight of pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, expressed by weight relative to the total weight of the composition in the form of a concentrate.

[0035] In a particular embodiment of the invention, the composition in the form of a concentrate has a Brookfield viscosity of between 5 mPa.s and 200 mPa.s, in particular of between 10 mPa.s and 100 mPa.s, as measured at 25°C. The viscosity within the meaning of the present invention is a Brookfield viscosity measured at room temperature (25°C), preferably after 24 hours, using a viscometer, for example a Brookfield digital viscometer (model LDVI Prime), spindle S 61 and rotation speed 100 RPM.

[0036] In a particular embodiment of the invention, the composition in the form of a concentrate has a pH of between 7.0 and 11.0, preferably a pH of between 7.5 and 10.0.

[0037] In a particular embodiment of the invention, the composition diluted in water according to the invention has a pH of between 5.0 and 8.0, preferably a pH between 7.0 and 8.0. Preferably, the diluted composition has a pH value compatible with topical application, in particular cutaneous application of the composition on the skin of an animal or human skin.

[0038] The invention also relates to a composition diluted in water, comprising: a) a composition in the form of a concentrate according to the invention; and b) water.

[0039] This dilution can be carried out by an end user (in particular extemporaneously) in any location, in any quantities, for example in small-scale or industrial-scale quantities (such as livestock buildings).

[0040] In a particular embodiment of the invention, the composition diluted in water is in the form of an aqueous suspension, in particular an oil-in-water (O / W) emulsion, preferably in the form of a homogeneous mixture.

[0041] In the context of the invention, the term "emulsion" refers to a mixture of two immiscible liquid substances, such as oil and water. In an oil-in-water (O / W) emulsion, the oil is dispersed in the water in the form of droplets, especially small droplets.

[0042] In the context of the invention, the term “homogeneous mixture” refers to a mixture whose different constituents cannot be distinguished with the naked eye.

[0043] In a preferred embodiment of the invention, the composition diluted in water comprises: a) 5% (v% / v%) of said composition in the form of a concentrate having a content ranging from 60% to 70% by weight, preferably 65% ​​by weight of the semiochemical composition; and b) 95% (v% / v%) water.

[0044] In another particular embodiment of the invention, the composition in the form of a concentrate according to the invention is diluted in water with a dilution factor equal to 1 / 20.

[0045] Preferably, said composition in the form of a concentrate has a content ranging from 60% to 70% by weight, preferably 65% ​​by weight of the semiochemical composition, and / or the composition diluted in water has a content ranging from 2% to 5% by weight, preferably 3 to 3.5% by weight, preferably 3.25% by weight of the semiochemical composition.

[0046] The invention also relates to a process for preparing a composition in the form of a concentrate according to the invention, comprising the following steps: a) mixing the semiochemical composition, said at least one fatty acid ester and polyoxyethylene sorbitan and optionally said at least one additive, with stirring and at a temperature between 65°C and 75°C, preferably at a temperature temperature of 70°C, so as to obtain a homogeneous mixture; b) optionally add a perfume; c) the composition is recovered in the form of a concentrate obtained in step a) or b).

[0047] In a particular embodiment of the process according to the invention, at the end of step a), the composition in the form of a concentrate is cooled to room temperature.

[0048] The invention also relates to a process for preparing a composition diluted in water, comprising a step of diluting the composition in the form of a concentrate according to the invention in water, in particular with a dilution factor equal to 1 / 20.

[0049] According to another aspect, the invention relates to a non-therapeutic use of a composition diluted in water according to the invention. According to this use, the composition diluted in water according to the invention is used to obtain the expected semiochemical effect(s) of the semiochemical composition that it contains. Thus, a composition diluted in water according to the invention is used to improve the management of the behaviors or interactions of the target animals or their well-being, by the transmission of information or signals vectorized by the semiochemical agents.

[0050] A use of the composition diluted in water according to the invention is for example a use as a tool or means for improving animal breeding. A use of the composition diluted in water according to the invention is for example a use as a tool or means for adapting the animal to its environment.

[0051] The use of the composition diluted in water according to the invention comprises the topical administration, in particular cutaneous, of said composition to an animal, in particular a mammal, or to a human, or to animals treated in a group.

[0052] In a particular embodiment according to the invention, the composition diluted in water is administered topically, in particular cutaneously, on the skin of an animal or on human skin.

[0053] In a particular embodiment according to the invention, the animal is a domestic animal or a farm animal, in particular a mammal, preferably the animal is chosen from the group consisting of pets such as rabbits, cats, dogs, birds or from the group of farm animals such as horses or production animals such as pigs, cattle, poultry, for example chickens.

[0054] In a particular embodiment according to the invention, the composition diluted in water comprises a composition in the form of a concentrate according to the invention comprising a semiochemical composition and water, said semiochemical composition comprising bis(2-ethylhexyl) adipate and diisobutyrate. l-isopropyl-2,2-dimethyltrimethylene, in particular from 40% to 60% by weight of bis(2-ethylhexyl) adipate and from 40% to 60% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, preferably 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; and relates to the non-therapeutic use of said composition diluted in water for topical, in particular cutaneous, administration to poultry such as chickens, in particular on the skin of poultry such as chickens, in particular for preventing infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum).

[0055] In another particular embodiment according to the invention, the composition diluted in water comprises a composition in the form of a concentrate according to the invention comprising a semiochemical composition and water, said semiochemical composition comprising bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, in particular from 40% to 60% by weight of bis(2-ethylhexyl) adipate and from 40% to 60% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, preferably 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate;and relates to the non-therapeutic use of said composition diluted in water for topical administration, in particular cutaneous to an animal, for example birds or mammals, in particular on the skin of birds or mammals, or to a human, in particular on human skin, in particular to prevent infestation or bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks.;

[0056] Preferably, in the context of the uses mentioned above, the composition diluted in water according to the invention comprises: a) 5% (v% / v%) of the composition in the form of a concentrate according to the invention having a content ranging from 60% to 70% by weight, preferably 65% ​​by weight of the semiochemical composition; and b) 95% (v% / v%) of water; and / or the composition in the form of a concentrate is diluted in water with a dilution factor equal to 1 / 20.

[0057] The above-mentioned uses of the composition diluted in water according to the invention are non-therapeutic uses, and exclude any therapeutic use carried out on the animal or human body. Examples

[0058] The following examples are given for purely illustrative purposes, and should not be interpreted in any way as limiting the invention.

[0059] Example 1. Concentrate that can be diluted in water

[0060] Compositions in the form of a concentrate dilutable in water according to the invention having the composition shown in the following Table 1 were prepared.

[0061] [Tables 1] Compound name INCI CAS No. Weight percentage Semiochemical composition CS 1 / / 65% Polysorbate 85 POLYSORBATE 85 9005-70-3 34.9% Tinogard TT PENTAERYTHRITY L TETRA- DLT-BUTYL HY- DROXYHYDROCIN NAMATE 6683-19-8 0.1%

[0062] Semiochemical compositions CS1 used as an example in the formulation of Table 1

[0063] CS1: 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of 1-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

[0064] Example 2. Process for preparing the concentrate which can be diluted in water according to Example 1

[0065] The concentrates which can be diluted in water according to Example 1 were prepared according to the following protocol: 1. In a container suitable for receiving the final volume of the mixture, the semiochemical composition CS1, Tinogard TT and Polysorbate 85 were weighed and added. 2. The mixture was then stirred and heated to 70°C until a homogeneous mixture was obtained. 3. The composition was recovered in the form of a concentrate. The composition in the form of a concentrate that could be diluted in water was orange or brown in color and of medium viscosity.

[0066] Example 3. Dilution of the composition in the form of a concentrate

[0067] For the use of the composition prepared in the form of a concentrate according to Example 1, a dilution is carried out for example by the end user. If the final diluted composition is composed of 3.25% of semiochemical composition, for example CS1, the dilution to be carried out is a dilution by 20 since the concentrate is 65% of semiochemical composition such as CSL Table 2 below shows examples of dilution for different volumes.

[0068] [Tables2] Component Dilution by 20 Concentrate according to example 1 (65%) (L) 2.5 5 10 25 Water (L) 47.5 95 190 475 Final mix (3.25%) 50L 100L 200L 500L

[0069] Thus, a 5l container of composition in the form of concentrate is for example used for a final volume of 100L.

[0070] Example 4. Organoleptic measurements of the composition in the form of a concentrate according to Example 1

[0071] 3 criteria (appearance, color, odor) were selected for the organo measurements leptics. Appearance: Liquid Color: Yellow / Brown Odor: Characteristic odor.

[0072] Example 5, pH measurements of the composition in the form of a concentrate according to example 1

[0073] The pH measurements were carried out using an LE 438 IP 67 electrode marketed by Mettler Toledo®. This is a 2-in-1 glass pH electrode with integrated temperature sensor and liquid electrolyte for rapid laboratory measurements; for aqueous samples, such as acids, bases, etc.

[0074] The specifications of this electrode are mentioned in the following Table 3.

[0075] [Tables3] Measuring range pH 0 - 14 Zero point 7.00 ± 0.25 Temperature range 0 - 80 °C Temperature sensor NTC 30 KQ Membrane resistance (25 °C) < 250 MQ Reference electrolyte 3 mol / L KC1 solution saturated with AgCl Reference system Ag / AgCl Reference diaphragm Gel

[0076] Before any measurement, the pH meter used was calibrated. Indeed, the nature of the semiochemical composition can cause the pH of the emulsion to change because certain semio- Chemicals have an acidic pH. In the context of topical application, particularly cutaneous, it is therefore necessary to measure the pH of each composition obtained and possibly adjust the pH. pH measurements were carried out after obtaining the composition in the form of a concentrate, or the composition diluted in water according to the invention, and are reported below: Concentrated at 65%: 7.5 < pH < 10.0 Diluted composition (dilution factor 1 / 20): 5.5 < pH < 7.5.

[0077] Example 6 Measurement of the viscosity of the composition in the form of a concentrate according to example 1

[0078] Viscosity is the resistance of a fluid to the sliding of one layer relative to another. For each composition, the viscosity must be checked after each manufacture. Viscosity is influenced by a number of factors including temperature, the measuring device used, the measuring speed used, the time of measurement relative to manufacture (measurements at T0 and T+24h, T+48h). The viscosity measurement must be carried out when the solution is at room temperature, preferably at T+24h.

[0079] The measurement of the viscosity of the composition in the form of a concentrate according to Example 1 was carried out using the Brookfield digital viscometer (model DV-I Prime), mobile S 61 and at a rotation speed of 100 RPM.

[0080] The DV-I Prime Brookfield viscometer measures the viscosity of fluids at a given velocity gradient. The operating principle consists of rotating a spindle (which is immersed in the liquid to be tested) by means of a calibrated spring. The measuring range (in centipoise or milliPascal-second) is determined by the spindle rotation speed, the size and shape of the spindle, the section where the spindle is rotating and the full scale of the calibrated spring torque.

[0081] The specifications of the DV-I Prime Brookfield viscometer are reported in the following Table 4.

[0082] [Table 4]: Speeds (rpm) 0.0; 0.3; 0.6; 1.5; 3; 6; 12; 30; 60; 0.5; 1; 2; 2.5; 4; 5; 10; 20; 50; 100 Viscosity Range (cP) 15 - 2,000,000 Operating Environment Temperature Range 0°C to 40°C (32°F to 104°F) 20% to 80% RH: Non-condensing Analog Torque Output 0-1 VDC (0 to 100% Torque) Viscosity measurement accuracy ± 1 °C: -of full scale Viscosity measurement reproducibility 0.2% of full scale used Spindles used S61; S62; S63; S64

[0083] Following these measurements, the composition in the form of a concentrate according to Example 1 had a viscosity of between 10 and 100 cP or mPa.s. References

[0084] - Silverstein, RM, 1977. "Complexity, diversity and specificity of behavior- modifying Chemicals; examples from Coleoptera and Hymenoptera," Chemical Control of Insect Behavior:Theory and Application. Publishers HH Shorey & JJMcKelvey pp.231-251 New York: Plénum Press); - Wyatt TD, 2003 "Pheromones and Animal Behavior. Communication by smell and taste, pp.1-4 New York: Cambridge University Press.

Claims

Claims

1. Composition in the form of a concentrate which can be diluted in water, comprising: a) at least one polyoxyethylene sorbitan fatty acid ester; b) a lipophilic and water-dispersible semiochemical composition, in particular a semiochemical composition comprising bis(2-ethylhexyl) adipate and 1-isopropyl-2,2-dimethyltrimethylene diisobutyrate in a content of at least 40% by weight of the composition in the form of a concentrate, the total sum of the compounds present in the composition in the form of a concentrate being equal to 100%.

2. Composition in the form of a concentrate according to claim 1, characterized in that the semiochemical composition comprises from 40% to 60% by weight of bis(2-ethylhexyl) adipate and from 40% to 60% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, the total sum of the compounds present in the semiochemical composition being equal to 100%.

3. Composition in the form of a concentrate according to claim 2, characterized in that the semiochemical composition comprises 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of 1-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

4. Composition in the form of a concentrate according to any one of claims 1 to 3, characterized in that the semiochemical composition is present in a content ranging from 60% to 70% by weight, preferably 65% ​​by weight, relative to the total weight of the composition in the form of a concentrate.

5. Composition in the form of a concentrate according to any one of claims 1 to 4, characterized in that said at least one ester of fatty acid and polyoxyethylene sorbitan is present in a content ranging from 25% to 60% by weight, preferably from 30% to 40% by weight, even more preferably 34.90% or 35% by weight, relative to the total weight of the composition in the form of a concentrate.

6. Composition in the form of a concentrate according to any one of claims 1 to 5, characterized in that it further comprises at least one additive chosen from the group consisting of a preservative agent, in particular an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

7. Composition in the form of a concentrate according to claim 6, characterized in that the antioxidant agent is chosen from cinnamic acids and their derivatives such as pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, vitamin A and derivatives, vitamin C and derivatives, and vitamin E and derivatives, preferably pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate.

8. Composition in the form of a concentrate according to any one of claims 1 to 7, characterized in that the antioxidant agent is present in a content ranging from 0.02% to 0.3% by weight, preferably 0.1% by weight, relative to the total weight of the composition in the form of a concentrate.

9. Composition in the form of a concentrate according to any one of claims 1 to 8, characterized in that it comprises: a) sorbitan polyoxyethylene trioleate; b) a semiochemical composition comprising bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; and c) pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate.

10. Composition in the form of a concentrate according to claim 9, characterized in that it comprises: a) from 25% to 60% by weight, preferably from 30% to 40% by weight, even more preferably from 34.9% or 35% by weight, expressed by weight relative to the total weight of the composition in the form of a concentrate, of polyoxyethylene sorbitan trioleate; b) from 60% to 70% by weight, preferably from 65% by weight, expressed by weight relative to the total weight of the composition in the form of a concentrate, of a semiochemical composition comprising bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, in particular from 40% to 60% by weight of bis(2-ethylhexyl) adipate and from 40% to 60% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, preferably 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate;and c) from 0.02% to 0.3% by weight, expressed by weight relative to the total weight of the composition in the form of a concentrate, of pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate.;

11. A composition diluted in water, comprising: a) a composition in the form of a concentrate according to any one of of claims 1 to 10; and b) water.

12. A water-diluted composition according to claim 11, comprising: a) 5% (v% / v%) of said composition in the form of a concentrate having a content ranging from 60% to 70% by weight, preferably 65% ​​by weight of the semiochemical composition; and b) 95% (v% / v%) of water.

13. A water-diluted composition according to claim 11, characterized in that the composition in the form of a concentrate is diluted in water with a dilution factor equal to 1 / 20.

14. Process for preparing a composition in the form of a concentrate according to any one of claims 1 to 10, comprising the following steps: a) mixing the semiochemical composition, said at least one fatty acid ester and polyoxyethylene sorbitan and optionally said at least one additive, with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous mixture; b) optionally adding a perfume; c) recovering the composition obtained in step a) or b) in the form of a concentrate.

15. Method according to claim 14, characterized in that at the end of step a), the composition in the form of a concentrate is cooled to room temperature.

16. Non-therapeutic use of a composition diluted in water according to any one of claims 11 to 13, for topical administration, in particular cutaneous administration to poultry such as chickens, in particular on the skin of poultry such as chickens, in particular for preventing infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum).

17. Non-therapeutic use of a water-diluted composition according to any one of claims 11 to 13, for topical, in particular cutaneous, administration to an animal, for example birds or mammals, in particular on the skin of birds or mammals, or to a human, in particular on human skin, in particular for preventing infestation or bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks.