SKIN CARE COMPOSITIONS

Abstract

SKIN CARE COMPOSITIONS Skin care compositions and, preferably, skin care compositions providing one or more improvements in the appearance of the skin and, in some cases, in the health of the skin are disclosed herein. According to one aspect of the invention, there is provided a skin care composition comprising hyaluronic acid or a salt thereof, a silicone-based surfactant, one or more peptides, an extract and a component.

Description

Title of the invention: COMPOSITIONS FOR SKIN CARE

[0001] CONTEXT

[0002] Reactive Oxygen Species (ROS) are free radicals that can react with various cellular proteins in the skin, for example, collagen, elastin, and glycosaminoglycans. ROS cause cross-linking of collagen and elastin, leading to the appearance of wrinkles and a decrease in the skin's ability to self-repair. Thus, skin damage caused by ROS may contribute to aging physiology or lead to skin disorders. Antioxidants can capture and reduce the excessive production of ROS and mitigate the damage they cause to cells in different tissues, including the skin.

[0003] Furthermore, in the skin health field, recent consumer trends require products to be as simple as possible, while still providing acceptable skin health benefits that consumers have become accustomed to with products containing a number of ingredients. However, when fewer ingredients are used, more emphasis is placed on optimizing the results and effectiveness of each ingredient to provide antioxidant and skin health benefits to the consumer.

[0004] BRIEF SUMMARY

[0005] This summary is intended only to present a simplified summary of certain aspects of one or more embodiments of the present disclosure. Other areas of application of the present disclosure will become apparent in the detailed description provided below. This summary is not intended to be an exhaustive overview, nor is it intended to identify key or crucial elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is to present one or more concepts in a simplified form as a prelude to the detailed description below.

[0006] Certain aspects of the invention relate to skin care compositions and, preferably, to skin care compositions providing one or more improvements to the appearance of the skin and, in some cases, to the health of the skin. According to one aspect of the invention, a skin care composition containing hyaluronic acid or a salt thereof, a silicone-based surfactant, one or more peptides, an extract and a fatty component is provided.

[0007] According to another aspect of the invention, a method for reducing wrinkles and / or improving the elasticity, homogeneity, luminosity and / or firmness of the skin is provided. In certain embodiments, the method comprises applying a skin care composition on the skin, said skin care composition containing hyaluronic acid or one of its salts, a silicone-based surfactant, one or more peptides, an extract and a fatty component.

[0008] It should be understood that the detailed description and specific examples, while indicating certain typical aspects of the disclosure, are provided solely for the purpose of illustration and do not limit the scope of the disclosure. Brief description of the drawings

[0009] The embodiment of the present technology will now be described, by way of example only, with reference to the attached figures, in which:

[0010] [Fig. 1] is a bar graph showing the reduction of oxidizing species after application of non-limiting exemplary compositions in accordance with one aspect of the invention;

[0011] [Fig. 2] is a bar graph of the effect on gene expression analysis following application of non-limiting exemplary compositions in accordance with one aspect of the invention;

[0012] [Fig. 3] is a bar graph of the effect on loricrin expression following application of non-limiting exemplary compositions in accordance with one aspect of the invention;

[0013] [Fig. 4] is a bar chart of the effect on the expression of ELOVL1, IVL, KLK5, KLK7 and TGM1 after application of non-limiting exemplary compositions in accordance with one aspect of the invention; and

[0014] [Fig. 5] is a bar chart of the effect on HBEGF, TGFB2 and FGF2 expression following application of non-limiting exemplary compositions in accordance with one aspect of the invention.

[0015] It should be understood that the various aspects are not limited to the conformations and instruments illustrated by the drawings. DETAILED DESCRIPTION

[0016] For purposes of illustration, the principles of the present invention are described with reference to various exemplary embodiments thereof. Although certain embodiments of the invention are specifically described herein, any person of ordinary skill in the art will readily recognize that the same principles may also be applied to and used in other compositions and methods. Before explaining in detail the disclosed embodiments of the present invention, it should be understood that the invention is not limited in its application to the details of any particular embodiment disclosed herein. The terminology used herein is intended to describe and not to limit.

[0017] In this document and in the appended claims the singular form of any class of ingredients refers not only to a chemical species of that class, but also to a mixture of such chemical species. The terms "comprising", "including" and "having" may be used interchangeably. The term "include" shall be interpreted as "include, but not be limited to". The term "including" shall be interpreted as "including, but not limited to".

[0018] As used herein, ranges serve as a shorthand way to describe each individual value within the range. Any value within the range can be selected as the endpoint of the range. Thus, a range of 1 to 5 specifically includes 1, 2, 3, 4, and 5, as well as subranges such as 2 - 5, 3 - 5, 2 - 3, 2 - 4, 1 - 4, etc.

[0019] When referring to a number, the term "about" means any number within a 10% window on either side of the number. For example, the phrase "about 2% by weight" means a number between 1.8% by weight and 2.2% by weight.

[0020] Unless otherwise indicated, abbreviations and symbols used herein have their ordinary meanings. The abbreviation "% by weight" means the percentage by weight relative to the skin care composition. The symbol "°" means a degree, such as a degree of temperature or a degree of angle. The symbols "h", "min", "ml", "nm" and "pm" mean hour, minute, milliliter, nanometer and micrometer, respectively. The abbreviation "UV-VIS" referring to a spectrometer or spectroscopy means Ultraviolet-Visible. The abbreviation "rpm" means revolutions per minute.

[0021] In chemical structures and names, the symbols "C", "H" and "O" denote carbon, hydrogen and oxygen respectively. The symbols "-", "=" and "=" denote a single bond, a double bond and a triple bond respectively.

[0022] “Volatile” as used herein means that the flash point is less than about 100°C. “Non-volatile,” as used herein, means that the flash point is above about 100°C.

[0023] Any member of a species list used to illustrate or define a genus may be mutually different from, overlap with, be a subset of, be equivalent to, be nearly identical to, or be identical to any other member of the species list. Furthermore, unless explicitly stated, for example when stating a Markush group, the list of species that define or illustrate the genus is open, and it is recognized that there may be other species that might define or illustrate the genus just as well, if not better, than any other species on the list.

[0024] The phrases "a mixture of", "a combination of", or "a combination of two or more of" do not require that the mixture include all of A, B, C, D, E, and F (although all of A, B, C, D, E, and F may be included). Rather, it indicates that a mixture of two or more of A, B, C, D, E, and F may be included. In other words, this is equivalent to the phrase "one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture of two or more of A, B, C, D, E, and F". Similarly, the phrase "a salt thereof" also refers to "salts of its salts".Thus, when the disclosure refers to "an element selected from the group consisting of A, B, C, D, E, F, a salt thereof and a mixture thereof", it indicates that one or more of the elements A, B, C, D and F, one or more of the salts of A, a salt of B, a salt of C, a salt of D, a salt of E and a salt of F, or a mixture of any two of the elements A, B, C, D, E and F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E and a salt of F may be included.

[0025] All components and elements positively stated in the present disclosure may be negatively excluded from the claims. In other words, the skin care compositions of the present disclosure may be free or substantially free of all components and elements positively stated in the present disclosure. In some cases, the skin care compositions of the present disclosure may be substantially free of non-incidental amounts of the ingredient(s) or compound(s) described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound added by itself to the skin care composition.For example, a skin care composition may be substantially free of a non-incidental amount of an ingredient or compound, although such ingredient(s) or compound(s) may be present as part of a raw material that is included as a mixture of two or more compounds.

[0026] Some of the identified component categories may overlap. In cases where there may be overlap and the skin care composition contains both components (or the composition contains more than two overlapping components), an overlapping compound does not represent more than one component. For example, some compounds may be characterized as both a surfactant and an emulsifier. If a particular skin care composition includes both a surfactant and an emulsifier, a compound characterized as both a surfactant and an emulsifier will serve only as a polyol or a sweetener - but not both at the same time.

[0027] In some instances, the skin care compositions of the present disclosure may be substantially free of non-incidental amounts or added amounts of the ingredient(s) or compound(s) described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound that is added by itself to the skin care composition. For example, a skin care composition may be substantially free of a non-incidental amount of an ingredient or compound, although that ingredient(s) or compound(s) may be present as part of a starting material that is included as a mixture of two or more compounds.

[0028] For readability, chemical functional groups are presented in their adjectival form; for each of the adjectives, the word "group" is implied. For example, the adjective "alkyl," without the noun following it, should be read as "an alkyl group."

[0029] As used herein, the term "subject" refers to individuals (e.g., humans) to be treated with the methods or compositions of the present invention. Subjects include, but are not limited to, mammals (e.g., murine, simian, equine, bovine, porcine, canine, feline, and the like) and, more preferably, humans. In the context of the invention, the term "subject" generally refers to an individual who will receive or has received treatment for a condition characterized by the presence of biofilm-forming bacteria, or in anticipation of possible exposure to biofilm-forming bacteria.

[0030] As used herein, the term "in vitro" refers to an artificial environment and to the processes or reactions that occur in an artificial environment. In vitro environments include, but are not limited to, test tubes and cell cultures. The term "in vivo" refers to the natural environment (e.g., an animal or a cell) and to the processes or reactions that occur in a natural environment.

[0031] Aspects of the invention relate to skin care compositions and, preferably, to skin care compositions providing one or more improvements in the appearance of the skin and, in some cases, in the health of the skin. According to one aspect of the invention, there is provided a skin care composition containing hyaluronic acid or a salt thereof, a silicone-based surfactant, one or more peptides, an extract and a fatty component.

[0032] According to another aspect of the invention, there is provided a method for reducing wrinkles and / or improving the elasticity, homogeneity, luminosity and / or firmness of the skin. In some embodiments, the method comprises applying a skin care composition thereto, wherein the skin care composition comprises hyaluronic acid or one of its salts, a silicone-based surfactant, one or more peptides, an extract and a fatty component.

[0033] The skin care compositions may be in the form of a serum, a lotion, a cream, a balm, a gel, a mesotherapy injection composition, and / or other similar products. In some preferred embodiments, the skin care composition is a topical skin care composition, which may be in the form of a serum, a lotion, a cream, a balm, and / or other similar products. In some embodiments, the skin care composition is in the form selected from: a serum, a cream, a moisturizer, a mask, a cleanser, a facial makeup, and a balm (e.g., a lip balm). In some aspects, the skin care compositions of the present disclosure may be applied by injection (e.g., subcutaneous or dermal injection).In some aspects, the skin care composition refers to a product intended for use in the home or professional setting. In some cases, the skin care composition may be in the form of an injectable mesotherapy composition.

[0034] In some embodiments, the skin care compositions may comprise a single phase, which contains all of the components and / or ingredients of the skin care composition. In other embodiments, the skin care composition may comprise two or more phases, for example, two, three, four, or five phases. The composition may comprise a single phase or be a multi-phase system, for example, a system comprising a polar phase and an oil phase, optionally in the form of a stable emulsion. For example, the skin care composition may be in the form of an emulsion comprising more than one phase, such as two or three phases. In some cases, the skin care composition may be in the form of an oil-in-water emulsion or a water-in-oil emulsion.In at least one preferred embodiment, the skin care composition is a topical cream comprising an oil-in-water emulsion.

[0035] Suitable components, such as those listed below, may be included or excluded from the formulations of the skin care compositions depending on the specific combination of other ingredients and the form of the skin care compositions. The skin care compositions of the present disclosure may be liquid, semi-solid, or solid. The skin care compositions may be provided in any container, tube or container with a porous cap, roll-on container, bottle, container with an open end, etc.

[0036] According to the invention, the skin care compositions comprise:

[0037] hyaluronic acid or one of its salts;

[0038] a silicone-based surfactant;

[0039] one or more peptides

[0040] an extract; and

[0041] a fatty component.

[0042] Skin care compositions generally comprise hyaluronic acid and / or a salt thereof. The hyaluronic acid and / or a salt thereof may comprise hyaluronic acid in the form of a salt, such as sodium hyaluronate. In some embodiments, the hyaluronic acid and / or a salt thereof comprises hyaluronic acid or non-adventitious amounts of hyaluronic acid. In other embodiments, the hyaluronic acid and / or a salt thereof comprises salts of hyaluronic acid (e.g., sodium hyaluronate) or non-adventitious amounts of salts of hyaluronic acid.

[0043] The amount of hyaluronic acid and / or a salt thereof in the skin care composition may be from about 0.05 to about 5% by weight, based on the total weight of the skin care composition. For example, the total amount of hyaluronic acid and / or a salt thereof in the skin care composition may be from about 0.05 to about 5% by weight, from about 0.05 to about 4% by weight, from about 0.05 to about 3% by weight, from about 0.05 to about 2% by weight, from about 0.05 to about 1.5% by weight, from about 0.05 to about 1% by weight, from about 0.05 to about 0.8% by weight, from about 0.05 to about 0.6% by weight, from about 0.05 to about 0.4% by weight; from about 0.1 to about 5% by weight, from about 0.1 to about 4% by weight, about 0.1 to about 3% by weight, about 0.1 to about 2% by weight, about 0.1 to about 1.5% by weight, about 0.1 to about 1% by weight, about 0.1 to about 0.8% by weight, about 0.1 to about 0.6% by weight, about 0.1 to about 0.4% by weight; about 0.2 to about 5% by weight, about 0.2 to about 4% by weight, about 0.2 to about 3% by weight, about 0.2 to about 2% by weight, about 0.2 to about 1.5% by weight, about 0.2 to about 1% by weight, about 0.2 to about 0.8% by weight, about 0.2 to about 0.6% by weight, about 0.2 to about 0.4% by weight; about 0.5 to about 5% by weight, about 0.5 to about 4% by weight, about 0.5 to about 3% by weight, about 0.5 to about 2% by weight, about 0.5 to about 1.5% by weight, about 0.5 to about 1% by weight; about 0.75 to about 5% by weight, about 0.75 to about 4% by weight, about 0.75 to about 3% by weight, about 0.75 to about 2% by weight, about 0.75 to about 1.5% by weight; from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight, from about 1 to about 1.5% by weight; from about 1.5 to about 5% by weight, from about 1.5 to . about 4% by weight, about 1.5 to about 3% by weight, about 1.5 to about 2% by weight; about 2 to about 5% by weight, about 2 to about 4% by weight, about 2 to about 3% by weight; about 3 to about 5% by weight, about 3 to about 4% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.Without being limited to any particular theory, certain embodiments of the skin care composition may provide desirable improvements to the appearance and / or health of the skin while utilizing a total amount of hyaluronic acid and / or a salt thereof of about 1 wt% or less, about 0.8 wt% or less, about 0.6 wt% or less, about 0.5 wt% or less, about 0.4 wt% or less, or any range formed from the ranges and upper limits mentioned in this paragraph, wherein the weight percentage is based on the total weight of the skin care composition.

[0044] The hyaluronic acid and / or a salt thereof may comprise non-chemically modified hyaluronic acid, chemically modified hyaluronic acid, cross-linked hyaluronic acid, hydrolyzed hyaluronic acid, or a combination of two or more thereof. For example, the hyaluronic acid and / or a salt thereof may comprise or consist of hydrolyzed hyaluronic acid(s). The hyaluronic acid and / or a salt thereof may have a low molecular weight (e.g., an average molecular weight of 300 kDA or less). In some embodiments, the hyaluronic acid and / or a salt thereof has an average molecular weight (MW) of about 100,000 Da or less. For example, the molecular weight of hyaluronic acid and / or a salt thereof is from about 10 kDa to about 75 kDa, from about 25 kDa to 75 kDa, from about 35 kDa to about 75 kDa, from about 40 kDa to about 75 kDa, from about 45 kDa to about 75 kDa, from about 50 kDa to about 75 kDa,from about 55 kDa to about 75 kDa, from about 60 kDa to about 75 kDa; from about 10 kDa to about 65 kDa, from about 25 kDa to 65 kDa, from about 35 kDa to about 65 kDa, from about 40 kDa to about 65 kDa, from about 45 kDa to about 65 kDa, from about 50 kDa to about 65 kDa, from about 55 kDa to about 65 kDa; from about 10 kDa to about 60 kDa, from about 25 kDa to 60 kDa, from about 35 kDa to about 60 kDa, from about 40 kDa to about 60 kDa, from about 45 kDa to about 60 kDa, from about 50 kDa to about 60 kDa; from about 10 kDa to about 55 kDa, from about 25 kDa to 55 kDa, from about 35 kDa to about 55 kDa, from about 40 kDa to about 55 kDa, from about 45 kDa to about 55 kDa; from about 10 kDa to about 50 kDa, from about 25 kDa to 50 kDa, from about 35 kDa to about 50 kDa, from about 40 kDa to about 50 kDa; from about 10 kDa to about 45 kDa, from about 25 kDa to 45 kDa; from about 10 kDa to about 40 kDa, from about 25 kDa to 40 kDa, from about 30 kDa to about 40 kDa,or any range or subrange thereof. In at least one mode of , embodiment, the skin care composition comprises hyaluronic acid having a molecular weight of about 50 kDa. In at least one embodiment, the hyaluronic acid and / or a salt thereof may comprise or consist of hydrolyzed hyaluronic acid(s) having a molecular weight of about 10 kDa to about 75 kDa.

[0045] Further, the skin care compositions generally comprise one or more peptides. The one or more peptides may comprise a plurality of peptides, such as 2, 3, 4, 5, 6, 7, 8, 9, 10 peptides, or any other range formed therefrom. For example, the skin care composition may comprise 2 to 10 peptides, 2 to 8 peptides, 2 to 7 peptides, 2 to 6 peptides, 2 to 5 peptides, 2 to 4 peptides; 3 to 10 peptides, 3 to 8 peptides, 3 to 7 peptides, 3 to 6 peptides, 3 to 5 peptides, 3 or 4 peptides; from 4 to 10 peptides, from 4 to 8 peptides, from 3 to 7 peptides, from 3 to 6 peptides, from 3 to 5 peptides, from 3 or 4 peptides; from 4 to 10 peptides, from 4 to 8 peptides, from 4 to 7 peptides, from 4 to 6 peptides, from 4 or 5 peptides; from 5 to 10 peptides, from 5 to 8 peptides, from 5 to 7 peptides, from 5 or 6 peptides; from 6 to 10 peptides, from 6 to 8 peptides, from 6 or 7 peptides, or any range or subrange formed from these.In at least one embodiment, the skin care composition comprises 2 or more peptides, 3 or more peptides, 4 or more peptides, 5 or more peptides, 6 or more peptides, 7 or more peptides, or 8 or more peptides.

[0046] The peptide(s) may comprise dipeptide diaminobutyroyl benzylamide diacetate, acetyl tetrapeptide-11, acetyl tetrapeptide-9, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, or a combination of two or more thereof. The peptide(s) may comprise or be selected from dipeptides. In at least one embodiment, the peptide(s) comprise or consist of dipeptide diaminobutyroyl benzylamide diacetate, acetyl tetrapeptide-11, acetyl tetrapeptide-9, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7. For example, the peptide(s) may comprise two or more peptides selected from the group consisting of dipeptide diaminobutyroyl benzylamide diacetate, acetyl tetrapeptide-11, acetyl tetrapeptide-9, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7.

[0047] The peptide(s) may be present in the skin care composition in an amount of up to about 1% by weight, based on the total weight of the skin care composition. In some cases, the skin care composition may include one or more peptides in an amount of up to about 0.7% by weight, up to about 0.4% by weight, up to about 0.2% by weight, up to about 0.1% by weight, or up to about 0.05% by weight; from about 0.001 to about 1% by weight; from about 0.001 to about 0.7% by weight, from about 0.001 to about 0.7% by weight; from about 0.01 to about 0.4% by weight, from about 0.01 about 0.2% by weight, about 0.01 to about 0.1% by weight, about 0.01 to about 0.05% by weight, about 0.01 to about 0.01% by weight; about 0.005 to about 0.7% by weight, about 0.005 to about 0.4% by weight, about 0.005 to about 0.2% by weight, about 0.005 to about 0.1% by weight; about 0.01 to about 1% by weight, about 0.01 to about 0.7% by weight, about 0.01 to about 0.4% by weight, about 0.01 to about 0.2% by weight, about 0.01 to about 0.1% by weight; from about 0.1 to about 1% by weight, from about 0.1 to about 0.7% by weight, from about 0.1 to about 0.4% by weight, from about 0.1 to about 0.2% by weight; from about 0.2 to about 0.7% by weight, from about 0.2 to about 0.4% by weight, from about 0.4 to about 1% by weight, from about 0.4 to about 0.7% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.

[0048] In addition to hyaluronic acid and / or its salt, vitamin E and the peptide, the skin care composition generally comprises an extract comprising Haberlea rhodopensis leaf extract, Silybum marianum extract, Pseudoalteromonas ferment extract or a combination of two or more thereof. In at least one embodiment, the extract consists essentially of Silybum marianum extract, Pseudoalteromonas ferment extract or a combination thereof. In some preferable embodiments, the skin care composition comprises Haberlea rhodopensis leaf extract.

[0049] The extract(s) may be present in the skin care composition in an amount of up to about 1% by weight, based on the total weight of the skin care composition. In some cases, the skin care composition may include extracts in an amount of up to about 0.7% by weight, up to about 0.4% by weight, up to about 0.2% by weight, up to about 0.1% by weight, or up to about 0.05% by weight; from about 0.001 to about 1% by weight; from about 0.001 to about 0.7% by weight, from about 0.001 to about 0.4% by weight, from about 0.001 to about 0.2% by weight, from about 0.001 to about 0.1% by weight, from about 0.001 to about 0.05% by weight, from about 0.001 to about 0.01% by weight; from about 0.005 to about 0.7% by weight, from about 0.005 to about 0.4% by weight, from about 0.005 to about 0.2% by weight, from about 0.005 to about 0.1% by weight; from about 0.01 to about 1% by weight, from about 0.01 to about 0.7% by weight, from about 0.01 to about 0.4% by weight, from about 0.01 to about 0.2% by weight, from about 0.01 to about 0.1% by weight; from about 0.1 to about 1% by weight, from about 0.1 to about 0.7% by weight, from about 0.1 to about 0.4% by weight, from about 0.1 to about 0.2% by weight; from about 0.2 to about 0.7% by weight, from about 0.2 to about 0.4% by weight, from about 0.4 to about 1% by weight, . from about 0.4 to about 0.7% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.

[0050] The skin care composition generally comprises one or more silicone-based surfactants. The amount of silicone-based surfactant(s) present in the skin care composition may be from about 0.1 to about 5% by weight, based on the total weight of the skin care composition.For example, the total amount of one or more silicone surfactants in the skin care composition may be about 0.1 to about 4 wt. %, about 0.1 to about 3 wt. %, about 0.1 to about 2 wt. %, about 0.1 to about 1 wt. %, about 0.5 to about 5 wt. %, about 0.5 to about 4 wt. %, about 0.5 to about 3 wt. %, about 0.5 to about 2 wt. %, about 1 to about 5 wt. %, about 1 to about 4 wt. %, about 1 to about 3 wt. %, about 1 to about 2 wt. %, about 2 to about 5 wt. %, about 2 to about 4 wt. %, about 2 to about 3 wt. %; from about 3 to about 5% by weight, from about 3 to about 4% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.

[0051] The silicone-based surfactant may comprise or consist of anionic silicone-based surfactants. For example, the silicone-based surfactant(s) may comprise methylsilanol mannuronate, hydroxyethylacetomonium PG-dimethicone, polyglyceryl lauryl polydimethylsiloxyethyl dimethicone, or a combination of two or more thereof.

[0052] In addition to the silicone-based surfactant(s), the skin care composition may include one or more nonionic surfactants, one or more amphoteric surfactants, one or more anionic surfactants, and / or one or more cationic surfactants. In some embodiments, however, the silicone-based surfactants are the only surfactants in the skin care composition.

[0053] In some embodiments, the skin care composition may include one or more nonionic surfactants in an amount that may vary, but may be from about 0.1 to about 5% by weight, based on the total weight of the skin care composition. In some instances, the skin care composition comprises one or more nonionic surfactants in an amount ranging from about 0.1 to about 5% by weight, from about 0.1 to about 4% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1% by weight; from about 0.5 to about 5% by weight, from about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight; wt.%; from about 1 to about 5 wt.%, from about 1 to about 4 wt.%, from about 1 to about 3 wt.%, from about 1 to about 2 wt.%; from about 2 to about 5 wt.%, from about 2 to about 4 wt.%, from about 2 to about 3 wt.%; from about 3 to about 5 wt.%, from about 3 to about 4 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0054] The skin care composition may comprise one or more nonionic surfactants selected from pegylated castor oil or oils, polyglycerol ester or esters, poloxamer(s), fatty alcohol ethoxylate(s), alkylphenol ethoxylate(s), tertiary amine oxide or oxides, glucoside(s), and a combination of two or more thereof. In at least one embodiment, the only surfactants in the skin care composition are nonionic surfactants selected from pegylated castor oil or oils and polyglycerol esters.

[0055] The pegylated castor oils may have a pegylated chain of about 10 to about 80. In some embodiments, the pegylated castor oils may have a pegylated chain of about 10 to about 80, about 10 to about 70, about 10 to about 60, about 10 to about 50, about 10 to about 40; about 20 to about 80, about 20 to about 70, about 20 to about 60, about 20 to about 50, about 20 to about 40; about 40 to about 80, about 40 to about 70, about 40 to about 60, about 60 to about 80, or any range or subrange thereof. In at least one embodiment, the nonionic surfactant(s) comprise several pegylated castor oils, including PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-20 castor oil, or a combination thereof.In at least one embodiment, the skin care composition comprises one or more nonionic surfactants comprising or consisting of PEG-60 hydrogenated castor oil and / or PEG-20 castor oil.

[0056] Other examples of nonionic surfactants worth mentioning include long-chain alkyl glucosides having C8-C22 alkyl groups; coconut fatty acid monoethanolamides such as cocamide MEA; coconut fatty acid diethanolamides, fatty alcohol ethoxylates (alkylpolyethylene glycols); alkylphenol polyethylene glycols; alkyl mercaptan polyethylene glycols; fatty amine ethoxylates (alkylaminopolyethylene glycols); fatty acid ethoxylates (acylpolyethylene glycols); polypropylene glycol ethoxylates; fatty acid alkylolamides (polyethylene glycol fatty acid amides); N-alkyl-, N-alkoxypolyhydroxy fatty acid amides; sucrose esters; sorbitol esters; polyglycol ethers; and combinations of two or more of these.

[0057] The skin care composition may optionally include one or more amphoteric surfactants.In some cases, the skin care composition comprises one or more amphoteric surfactants in an amount of from about 0.1 to about 5% by weight, from about 0.1 to about 4% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1% by weight; from about 0.5 to about 5% by weight, from about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight; from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight; from about 2 to about 5% by weight, from about 2 to about 4% by weight, from about 2 to about 3% by weight; from about 3 to about 5% by weight, from about 3 to about 4% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.

[0058] Amphoteric surfactants include, among others, derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical may be linear or branched and in which one of the aliphatic substituents contains about 8 to about 18 carbon atoms and the other contains a water-solubilizing anionic group, for example, carboxy, sulfonate, sulfate, phosphate or phosphonate. Examples of such compounds include sodium 3-dodecylaminopropionate, sodium 3-dodecylaminopropane sulfonate, N-alkyl taurines and N-higher alkyl aspartic acids.

[0059] Other examples of amphoteric surfactants include, but are not limited to, a range of betaines, including, for example, high alkyl betaines, such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxy-methyl betaine, lauryl dimethyl alpha-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl)carboxy methyl betaine, stearyl bis-(2-hydroxypropyl)carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, and lauryl bis-(2-hydroxypropyl)alpha-carboxyethyl betaine, sulfobetaines such as coco dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, amido-betaines, amidosulfobetaines and the like. Betaines having a long-chain alkyl group, particularly coco, may be useful, as may those that include an amido group, such as cocamidopropyl and cocoamidoethyl betaines.The amphoteric surfactant(s) may be in the form of a salt.

[0060] The skin care composition may optionally include one or more anionic surfactants. In some cases, the skin care composition comprises one or more anionic surfactants in an amount of about 0.1 to about 5% by weight, about 0.1 to about 4% by weight, about 0.1 to about 3% by weight, about 0.1 to about 2% by weight, about 0.1 to about 1% by weight; about 0.5 to about 5% by weight, about 0.5 to about 4% by weight, about 0.5 to about 3% by weight, about 0.5 to about 2% by weight.%; from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight; from about 2 to about 5% by weight, from about 2 to about 4% by weight, from about 2 to about 3% by weight; from about 3 to about 5% by weight, from about 3 to about 4% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.

[0061] The anionic surfactant(s) may be selected from long-chain (C6-C22) alkylated materials such as long-chain alkyl sulfates, long-chain alkyl sulfonates, long-chain alkyl phosphates, long-chain alkyl ether sulfates, long-chain alkyl alpha olefin sulfonates, long-chain alkyl taurates, long-chain alkyl isethionates (SCI), long-chain glyceryl ether sulfonates (AGES), sulfosuccinates, or a combination of two or more thereof. These anionic surfactants may be alkoxylated, for example, ethoxylated, although alkoxylation is not necessary. These surfactants are generally highly soluble in water in their sodium, potassium, alkyl, and ammonium salt or ammonium alkanol forms and can provide high foaming cleaning power.For example, the anionic surfactants may include sodium laureth sulfate, sodium lauryl sulfate, sodium pareth sulfate, and combinations thereof. The anionic surfactants may be in salt form. The skin care composition may include or be free of cationic surfactants.

[0062] Skin care compositions generally comprise a fatty component consisting of one or more fatty compounds. The fatty component may comprise a fatty ester, a fatty alcohol, a fatty ether, an oil, a wax, or a combination of two or more thereof. The fatty component may be present in an amount ranging from about 7 to about 40% by weight, based on the total weight of the skin care composition. In some instances, the one or more fatty compounds are present in an amount of about 7 to about 40% by weight, about 7 to about 36% by weight, about 7 to about 32% by weight, about 7 to about 29% by weight, about 7 to about 26% by weight, about 7 to about 23% by weight, about 7 to about 19% by weight, from about 7 to about 15% by weight; from about 7 to about 40% by weight, from about 7 to about 36% by weight, from about 7 to about 32% by weight, from about 7 to about 29% by weight, from about 7 to about 26% by weight, from about 7 to about 23% by weight, from about 7 to about 19% by weight, from about 7 to about 15% by weight; from about 12 to about 40% by weight, from about 12 to about 36% by weight, from about 12 to about 32% by weight, from about 12 to about 29% by weight, from about 12 to about 26% by weight, from about 12 to about 23% by weight, from about 12 to about 19% by weight; from about 17 to about 40% by weight, from about 17 to about 36% by weight, from about 17 to about 32% by weight, from about 17 to about 29% by weight, from about 17 to about 26% by weight, from about 17 to about 23% by weight;from about 21 to about 40% by weight, from about 21 to about 36% by weight, from about 21 to about 32% by weight, from about 21 to about 29% by weight, from about 21 to about 26% by weight; from about 25 to about 40% by weight, from about 25 to about 36% by weight, from about 25 to about 32% by weight, from about 25 to about 29% by weight; from about 28 to about 40% by weight, from about 28 to about 36% by weight, from about 28 to about 32% by weight; from about 31 to about 40% by weight, from about 31 to about 36% by weight, or any range or subrange thereof, based on the total weight of the skin care composition. ;

[0063] The fatty compounds may include or be selected from one or more oils. The term "oil" refers to any fatty substance that is in liquid form at room temperature (24-25°C) and atmospheric pressure (760 mmHg). The oil may be a hydrocarbon-based oil, such as a saturated hydrocarbon oil, an unsaturated hydrocarbon oil, lipids, triglycerides, a natural oil, and / or a synthetic oil. The oil(s) may be synthetic oils and / or vegetable oils. For example, the oil may be a synthetic oil, such as a mineral oil and / or an alkane (paraffins). Light (low viscosity) oils based on highly branched hydrocarbons may also be suitable in some cases. In at least one embodiment, the skin care composition comprises an oil, such as isododecane, isodecane, decane, dodecane, or a combination of two or more thereof.

[0064] In some embodiments, the oil is selected from plant or vegetable based oils, such as coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower seed oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina oil, pennycress oil, castor oil, wheat germ oil, apricot kernel oil, pistachio oil, poppy seed oil, pine oil, avocado oil, hazelnut oil, grapeseed oil, rapeseed oil, cade oil, peach kernel oil, coffee bean oil, jojoba oil, and a mixture thereof. In at least one embodiment, the oil or oils are selected from the fatty component comprising a vegetable oil selected from sunflower oil, corn oil, Rosa moschata seed oil, soybean oil, pumpkin oil, hydrogenated vegetable oil, grape seed oil, sesame seed oil, hazelnut oil, apricot oil, macadamia oil, arara oil, castor oil, avocado oil, caprylic / capric acid triglycerides, jojoba oil and shea butter oil, and a combination of two or more thereof.In at least one preferred embodiment, the skin care composition comprises a vegetable oil selected from corn oil, Rosa moschata seed oil, hydrogenated vegetable oil, or a combination of two or more thereof.

[0065] The oil may be one of the cyclic, linear or branched, volatile or non-volatile silicone oils, unmodified or modified with organic groups. The silicone oil may be selected from polydialkylsiloxanes, such as polydimethylsiloxanes (PDMS), and liquid polyorganosiloxanes. In some cases, the silicone oil may be selected from polydialkylsiloxanes, octamethylcyclotetrasiloxane, tetra(trimethylsilyl)pentaerythritol, octamethylcyclotetrasiloxane, polydiphenylsiloxanes, polyalkylarylsiloxanes, or a combination of two or more thereof. Skin-compatible oils can be silicone-based, for example, linear and cyclic polydimethyl siloxane, organofunctional silicones (alkyl and alkyl aryl), and amino silicones.

[0066] Other skin-compatible oils include a range of liquid hydrocarbons, for example, linear and branched oils such as liquid paraffin, squalene, squalane, mineral oil, low viscosity synthetic hydrocarbons, such as polyalphaolefins and polybutene. In at least one preferred embodiment, the oil comprises or consists of a dimethicone.

[0067] The fatty compounds may, in certain cases, include or be chosen from one or more waxes. Non-limiting examples of waxes in this category include, for example, synthetic wax, ceresin, paraffin, ozokerite, polyethylene waxes, illipe butter, beeswax, carnauba wax, microcrystalline wax, lanolin, lanolin derivatives, candelilla, cocoa butter, shellac wax, spermaceti, bran wax, kapok wax, sugarcane wax, montan wax, whale wax, berry wax, acacia flower wax, vegetable waxes [such as sunflower (Helianthus annuus) seed, carnauba, candelilla, ouricure or Japan, cork fiber or sugarcane wax], or a mixture of these waxes. In some embodiments, the component fat comprises a wax selected from Rhus verniciflua bark wax, Butyrospermum parkii (shea) butter or a combination thereof.

[0068] The fatty component may comprise a fatty ester selected from stearyl stearate, dihydroabietyl behenate, octyldodecyl behenate, isocetyl behenate, isostearyl lactate, lauryl lactate, linoleyl lactate, oleyl lactate, isostearyl octanoate, isocetyl octanoate, octyl octanoate, decyl oleate, isocetyl isostearate, isocetyl laurate, isocetyl stearate, isodecyl octanoate, isodecyl oleate, isonyl isononanoate, isostearyl palmitate, ricinoleate methyl acetyl, octyl isonanoate, 2-ethylhexyl isonanoate, octyldodecyl erucate, oleyl erucate, ethyl palmitate, isopropyl palmitate, such as 2-ethylhexyl palmitate, 2-octyldecyl, alkyl myristates such as 2-octyldodecyl isopropyl myristate, isobutyl stearate, 2-hexyldecyl laurate, isocetyl stearate, octyldodecyl stearoyl stearate,or a combination thereof. In some embodiments, the fatty ester is selected from glycerol fatty esters, sorbitan fatty esters, ethoxylated fatty esters, synthetic esters, and a combination of two or more thereof.

[0069] The fatty component may comprise one or more liquid fatty alcohols. The fatty alcohol may be selected from linear or branched, saturated or unsaturated, preferably unsaturated or branched, alcohols comprising from 6 to 40 carbon atoms, preferably from 8 to 30 carbon atoms. Examples of fatty alcohols include octyldodecanol, 2-butyloctanol, 2-hexyldecanol, 2-undecylpentadecanol, isostearyl alcohol, oleyl alcohol, linolenic alcohol, ricinoleyl alcohol, undecylenyl alcohol and linoleyl alcohol, as well as a combination of two or more thereof.

[0070] The skin care composition may comprise one or more polyols, for example in an amount of about 4 to about 32% by weight, based on the total weight of the skin care composition.For example, the skin care composition may include one or more polyols in an amount ranging from about 4 to about 32% by weight, from about 4 to about 28% by weight, from about 4 to about 22% by weight, from about 4 to about 19% by weight, from about 4 to about 16% by weight, from about 4 to about 13% by weight; from about 7 to about 32% by weight, from about 7 to about 28% by weight, from about 7 to about 22% by weight, from about 7 to about 19% by weight, from about 7 to about 16% by weight, from about 7 to about 13% by weight; from about 10 to about 32% by weight, from about 10 to about 28% by weight, from about 10 to about 22% by weight, from about 10 to about 19% by weight, from about 10 to about 16% by weight; from about 13 to about 32% by weight, from about 13 to about 28% by weight, from about 13 to about . 22% by weight, from about 13 to about 19% by weight; from about 16 to about 32% by weight, from about 16 to about 28% by weight, from about 16 to about 22% by weight, from about 16 to about 19% by weight; from about 19 to about 32% by weight, from about 19 to about 28% by weight, from about 19 to about 24% by weight; from about 10 to about 28% by weight, from about 10 to about 22% by weight, from about 10 to about 19% by weight, from about 10 to about 16% by weight. %, from about 19 to about 24% by weight; from about 22 to about 32% by weight, from about 22 to about 28% by weight; from about 25 to about 32% by weight, from about 25 to about 28% by weight, from about 28 to about 32% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.

[0071] Advantageously, the polyol(s) comprise a plurality of polyols, the plurality of polyols comprising glycerin and one or more glycols.

[0072] The polyol(s) may be selected from glycols or compounds having many hydroxyl groups. The term "polyol" should be interpreted as meaning, for the purposes of the present disclosure, an organic molecule comprising at least two free hydroxyl groups. The polyols of the skin care composition may be glycols or compounds with many hydroxyl groups. In some cases, the polyol(s) are selected from the group of C2-C32 polyols. The polyol(s) may have from 2 to 32 carbon atoms, from 3 to 16 carbon atoms or from 3 to 12 carbon atoms.

[0073] Polyols that may be included in the skin care composition, in some cases, include ethylene glycol, propylene glycol, butylene glycol, caprylyl glycol, hexylene glycol, glycerin, diglycerin, diethylene glycol, and dipropylene glycol, and mixtures thereof. In some cases, the polyol is propylene glycol and / or caprylyl glycol. In other cases, the skin care composition includes at least propylene glycol, and optionally one or more polyols other than propylene glycol, such as glycerin and / or hexanediol.

[0074] Non-limiting examples of polyols that may optionally be included in the skin care composition include and / or may be selected from alkanediols such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, caprylyl glycol, 1,2-hexanediol, 1,2-pentanediol and 4-methyl-1,2-pentanediol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol mono-n-propyl ether, diethylene glycol mono-isopropyl ether, diethylene glycol mono-isopropyl ether, diethylene glycol mono-n-butyl ether, diethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1-methyl-l-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-isopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, dipropylene glycol mono-isopropyl ether, sorbitol, sorbitan, triacetin, and a combination of two or more of these.

[0075] The polyol(s) may optionally be glycols or glycol ethers such as, for example, monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or their ethers such as, e.g., monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, e.g., monoethyl ether or monobutyl ether of diethylene glycol. In some cases, the polyol(s) may include or be selected from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, 1,3-propanediol, diethylene glycol, dipropylene glycol, 1,4-butanediol, 1,5-pentanediol, hexane-1,6-diol, glycerin, diglycerin, caprylyl glycol, and a mixture thereof.Non-limiting examples of polyols that may be included in the skin care composition, in some instances, include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, diglycerin, diethylene glycol and dipropylene glycol, and a combination of two or more thereof.

[0076] In some embodiments, the skin care composition comprises two or more polyols. In at least one embodiment, the skin care composition comprises propylene glycol and glycerin. In some instances, the polyols comprise propylene glycol and glycerin. In some preferred embodiments, the skin care compositions may have a polyol system comprising propylene glycol and glycerin in a weight ratio of propylene glycol to glycerin of about 2:1 to about 1:3. For example, the skin care composition may have a weight ratio of propylene glycol to glycerin of about 2:1 to about 1:3, about 1:1 to about 1:3, about 1:1.25 to about 1:3, about 1:1.5 to about 1:3, about 1:1.75 to about 1:3, about 1:2 to about 1:3, about 1:1 to about 1:2.5, about 1:1.25 to about 1:2.5, about 1:1.5 to about 1:2.5, from about 1:1.5 to about 1:2.5, . from about 1:1.75 to about 1:2.5, from about 1:2 to about 1:2; from about 1:1 to about 1:2, from about 1:1.25 to about 1:2, from about 1:1.5 to about 1:2, about 1:1.75 to about 1:2; from about 1:1 to about 1:1.5, from about 1:1.25 to about 1:1.5, from about 1:1 to about 1:1.25, or any range or subrange thereof.

[0077] The skin care compositions may optionally comprise one or more humectants. The one or more humectants may be selected from the polyols described herein. Examples of humectants that may be incorporated in certain embodiments include triethylene glycol, tripropylene glycol, propylene glycol, caprylyl glycol, glycerin, polyethylene glycols, polypropylene glycol, glycerin, sorbitol, hexylene glycol, butylene glycol, hyaluronic acid, 1,2 hexanediol, saccharide isomerate, and a combination of two or more thereof. In some cases, the one or more humectants comprise at least one of the following: glycerin, caprylyl glycol, propylene glycol, or polyethylene glycol, and, optionally, one or more additional humectants.Humectants can reduce evaporation and aid in preservation by decreasing water activity and also impart a desirable sweetness or flavor to the compositions. In at least one embodiment, the humectant(s) comprise glycerin.

[0078] Without being limited to any particular theory, it is believed that skin care compositions may provide enhanced and / or additional benefits by incorporating certain amino acids, vitamin E, vitamin B, and / or pyrrolidone carboxylic acid and / or salts thereof in certain amounts and ratios. For example, the addition of pyrrolidone carboxylic acid and / or sodium PCA and / or niacinamide / vitamin B3 in combination with vitamin E (e.g., alpha-tocopherol) and a thiourea derivative of histidine (e.g., ergothioneine) may unexpectedly enhance and / or provide additional benefits in combination with the components of the skin care compositions disclosed herein.

[0079] The skin care composition may include a vitamin E. As used herein, unless otherwise indicated, the term "vitamin E" refers to a family of four tocopherol isomers and four tocotrienol isomers. All eight vitamin E isomers have a 6-chromanol ring structure and a side chain. The four tocopherols have fully saturated side chains and include alpha-tocopherol, gamma-tocopherol, beta-tocopherol, and delta-tocopherol. The four tocotrienols include unsaturated side chains as well as alpha-tocotrienol, gamma-tocotrienol, beta-tocotrienol, and delta-tocotrienol. For example, vitamin E may be or include one or more of alpha-tocopherol, gamma-tocopherol, beta-tocopherol, delta-tocopherol, alpha-tocotrienol, gamma-tocotrienol, beta-tocotrienol, delta-tocotrienol, or any combination thereof. In at least one embodiment, the vitamin E comprises at least one of the four tocopherols. It should be noted that the vitamin E and / or its isomers may be or include natural forms of vitamin E, synthetic forms of vitamin E, or combinations thereof. One or more of the vitamin E isomers may be in the "d" form, the "1" form, or mixtures thereof. In some embodiments, the vitamin E is vitamin E acetate or vitamin E succinate. In some instances, the vitamin E is tocopheryl acetate.

[0080] In some embodiments, the skin care composition comprises one or more vitamin E selected from vitamin E acetate, vitamin E succinate, vitamin E acetate, or a combination of two or more of these vitamins.Vitamin E may, in some instances, be selected from the group consisting of alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, delta-tocotrienol, tocopherol acetate, tocopherol phosphate, natural extracts enriched with vitamin E derivatives, and combinations of two or more thereof. In at least one instance, vitamin E comprises tocopherol (e.g., alpha-tocopherol) or topically acceptable salts thereof.

[0081] The total amount of vitamin E in the skin care compositions may be from about 0.05 to about 5% by weight, based on the total weight of the skin care composition. For example, the total amount of vitamin E in the skin care composition may be from about 0.05 to about 3% by weight, from about 0.05 to about 1.5% by weight, from about 0.05 to about 1% by weight, from about 0.05 to about 0.8% by weight, from about 0.05 to about 0.6% by weight, from about 0.05 to about 0.4% by weight; from about 0.1 to about 5% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 1.5% by weight, from about 0.1 to about 1% by weight, from about 0.1 to about 0.8% by weight, from about 0.1 to about 0.6% by weight, from about 0.1 to about 0.4% by weight; from about 0.2 to about 5% by weight, from about 0.2 to about 3% by weight, about 0.2 to about 1.5% by weight, about 0.2 to about 1% by weight, about 0.2 to about 0.8% by weight, about 0.2 to about 0.6% by weight, about 0.2 to about 0.4% by weight; about 0.5 to about 5% by weight, about 0.5 to about 3% by weight, about 0.5 to about 1.5% by weight, about 0.5 to about 1% by weight; about 0.75 to about 5% by weight, about 0.75 to about 3% by weight, about 0.75 to about 1.5% by weight; from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight, from about 1 to about 1.5% by weight; from about 1.5 to about 5% by weight, from about 1.5 to about 4% by weight, from about 1.5 to about 3% by weight. weight, from about 1.5 to about 2% by weight; from about 2 to about 5% by weight, from about 2 to about 4% by weight, from about 2 to about 3% by weight; from about 3 to about 5% by weight, from about 3 to about 4% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.

[0082] In some embodiments, the skin care composition comprises a histidine thiourea derivative. The histidine thiourea derivative may comprise ergothioneine or, in some embodiments, consists of ergothioneine. The thiourea derivative of histidine (e.g., ergothioneine) may be present in an amount ranging from about 0.0001 to about 2 wt. %, for example, from about 0.0001 to about 0.5 wt. %, from about 0.0001 to about 0.1 wt. %, from about 0.0001 to about 0.05 wt. %, from about 0.0001 to about 0.01 wt. %, from about 0.0001 to about 0.009 wt. %, from about 0.0001 to about 0.008 wt. %, from about 0.0001 to about 0.0075 wt. %; from 0.001 to about 2 wt. %, from about 0.001 to about 1.5 wt. %, from about 0.001 to about 1.25 wt. %, from about 0.001 to about 1 wt. %, from about 0.001 to about 0.5 wt. %, from about 0.001 to about 0.1 wt. %, from about 0.001 to about 0.05 wt. %, from about 0.001 to about 0.01 wt. %, from about 0.001 to about 0.009 wt. %, from about 0.001 to about 0.008% by weight, from about 0.001 to about 0.0075% by weight, from about 0.001 to about 0.007% by weight, from about 0.001 to about 0.0065% by weight, from about 0.001 to about 0.006% by weight, from about 0.001 to about 0.0055% by weight, from about 0.001 to about 0.005% by weight, from about 0.001 to about 0.0045% by weight, from about 0.001 to about 0.005% by weight, from about 0.001 to about 0.005% by weight, from about 0.001 to about 0.004% by weight weight, from about 0.001 to about 0.0035 wt%, from about 0.001 to about 0.003 wt%, from about 0.001 to about 0.0025 wt%, from about 0.001 to about 0.002 wt%, from about 0.001 to about 0.0015 wt%, or any range or subrange thereof, based on the total weight of the composition (e.g. the weight of the active ingredient), where the weight refers to the active weight of the thiourea derivative of histidine or EGT).In some embodiments, the thiourea derivative of histidine (e.g., ergothioneine) is present in an amount of about 0.0015 wt.%, about 0.002 wt.%, about 0.0025 wt.%, about 0.003%, about 0.0035 wt.%, about 0.004 wt.%, about 0.0045 wt.%, about 0.005 wt.%, about 0.0055 wt.%, about 0.006 wt.%, about 0.0065 wt.%, about 0.007 wt.%, about 0.007 wt.%, about 0.0075 wt.%, about 0.008 wt.%, about 0.009% by weight, about 0.01% by weight, about 0.05% by weight, about 0.1% by weight, about 0.5% by weight, about 1% by weight, or any range or . sub-range formed of these, relative to the total weight of the composition (e.g. the weight referring to the active weight of the thiourea derivative of histidine or EGT).

[0083] The skin care composition may comprise one or more vitamins B. Vitamin B may include or consist of vitamin B3 and / or its derivatives. The formula of vitamin B3 may include the following structure:

[0084] where R is -CONH2 (i.e. niacinamide), -COOH (i.e. nicotinic acid) or -CH2 OH (i.e. nicotinic alcohol); a derivative thereof and / or a salt thereof.

[0085] Vitamin B3 and / or one of its derivatives may be selected from the group consisting of nicotinic acid esters, non-vasodilating nicotinic acid esters, nicotinic amino acids, nicotinic alcohol esters of carboxylic acids (e.g., straight or branched chain, cyclic or acyclic, saturated or unsaturated - including aromatic), substituted or unsubstituted nicotinic acid N-oxide, niacinamide N-oxide, tocopherol nicotinate, inositol hexanicotinate, and a combination of two or more thereof. Examples of niacinamide derivatives include nicotinylated amino acids, derived, for example, from the reaction of an activated nicotinic acid compound (e.g., nicotinic acid azide or nicotinyl chloride) with an amino acid, and nicotinic alcohol esters of organic carboxylic acids (e.g., C1-C18).Examples of such derivatives include nicotinuric acid and nicotinyl hydroxamic acid.

[0086] Other derivatives of niacinamide include nicotinic alcohol esters, such as nicotinic alcohol esters of carboxylic acids, salicylic acid, acetic acid, glycolic acid, palmitic acid and others. Other examples of niacinamide derivatives include 2-chloronicotinamide, 6-aminonicotinamide, 6-methylnicotinamide, n-methylnicotinamide, n,n-diethylnicotinamide, n-(hydroxymethyl)-nicotinamide, quinolinic acid amide, nicotinanilide, n-benzylnicotinamide, n-ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methyl-isonicotinic acid, thionicotinamide, nialamide, 1-(3-pyridylmethyl)urea, 2-mercaptonicotinic acid, nicomol, niaprazine, and combinations thereof. In at least one embodiment, the vitamin B comprises or consists of niacinamide.

[0087] The amount of vitamin B present in the skin care composition may be from about 0.05 to about 5% by weight, based on the total weight of the skin care composition. For example, the skin care composition skin may comprise a total amount of vitamin B of about 0.05 to about 4% by weight, about 0.05 to about 3% by weight, about 0.05 to about 2% by weight, about 0.05 to about 1% by weight, about 0.05 to about 0.7% by weight; about 0.1 to about 4% by weight, about 0.1 to about 3% by weight, about 0.1 to about 2% by weight, about 0.1 to about 1% by weight, about 0.1 to about 0.7% by weight; about 0.3 to about 5% by weight; about 0.3 to about 4% by weight; about 0.3 to about 3% by weight; from about 0.3 to about 1% by weight, from about 0.3 to about 0.7% by weight; from about 0.5 to about 5% by weight, from about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight, from about 0.5 to about 1% by weight, from about 0.5 to about 0.7% by weight;from about 0.7 to about 5% by weight, from about 0.7 to about 4% by weight, from about 0.7 to about 3% by weight, from about 0.7 to about 2% by weight, from about 0.7 to about 1% by weight; from about 1 to about 5% by weight; from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight, from about 1 to about 1.5% by weight, from about 1 to about 1.25% by weight; from about 1.25 to about 5% by weight, from about 1.25 to about 4% by weight, from about 1.25 to about 3% by weight, from about 1.25 to about 2% by weight; from about 1.5 to about 5% by weight, from about 1.5 to about 4% by weight, from about 1.5 to about 3% by weight, from about 1.5 to about 2% by weight; from about 2 to about 5% by weight, from about 2 to about 4% by weight, from about 2 to about 3% by weight;from about 3 to about 5% by weight, from about 3 to about 4% by weight, or any range or subrange thereof, based on the total weight of the skin care composition. In some embodiments, the amount of vitamin B in the skin care composition is about 4.75 wt%, about 4.5 wt%, about 4.25 wt%, about 4 wt%, about 3.75 wt%, about 3.5 wt%, about 3.25 wt%, about 3 wt%, about 2.75 wt%, about 2.5 wt%, about 2.25 wt%, about 2 wt%, about 1.75 wt%, about 1.5 wt%, about 1.25 wt%, about 1 wt%, about 0.5 wt%, or any range thereof, based on the total weight of the composition. ;

[0088] Pyrrolidone carboxylic acid and / or a salt thereof may be incorporated into certain embodiments of the skin care composition. The pyrrolidone carboxylic acid and / or a salt thereof may be in the form of a salt, such as sodium PCA. In certain embodiments, the total amount of pyrrolidone carboxylic acid and / or a salt thereof is pyrrolidone carboxylic acid or non-incidental amounts of pyrrolidone carboxylic acid. In other embodiments, the total amount of pyrrolidone-carboxylic acid and / or a salt thereof consists of salts of pyrrolidone-carboxylic acid (e.g. sodium PCA) or non-accidental amounts of salts of pyrrolidone-carboxylic acid. Pyrrolidone-carboxylic acid and / or a salt thereof may include L-pyrrolidone-carboxylic acid and / or a salt thereof.

[0089] In some embodiments, the skin care composition comprises pyrrolidone carboxylic acid and / or its salt(s) in an amount of about 0.05 to about 5% by weight, based on the total weight of the skin care composition. For example, the total amount of pyrrolidone carboxylic acid and / or salt(s) thereof present in the skin care composition may be about 0.05 to about 4% by weight, about 0.05 to about 3% by weight, about 0.05 to about 2% by weight, about 0.05 to about 1% by weight, about 0.05 to about 0.7% by weight; from about 0.1 to about 5 wt%, from about 0.1 to about 4 wt%, from about 0.1 to about 3 wt%, from about 0.1 to about 2 wt%, from about 0.1 to about 1 wt%, from about 0.1 to about 0.7 wt%;from about 0.3 to about 5% by weight, from about 0.3 to about 4% by weight, from about 0.3 to about 3% by weight, from about 0.3 to about 2% by weight, from about 0.3 to about 1% by weight, from about 0.3 to about 0.7% by weight; from about 0.5 to about 5% by weight, from about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight, from about 0.5 to about 1% by weight, from about 0.5 to about 0.7% by weight; from about 0.7 to about 5% by weight, from about 0.7 to about 4% by weight, from about 0.7 to about 3% by weight, from about 0.7 to about 2% by weight, from about 0.7 to about 1% by weight; from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight, from about 1 to about 1.5% by weight, from about 1 to about 1.25% by weight;from about 1.25 to about 5% by weight, from about 1.25 to about 4% by weight, from about 1.25 to about 3% by weight, about 1.25 to about 2% by weight; from about 1.5 to about 5% by weight, about 1.5 to about 4% by weight, about 1.5 to about 3% by weight, about 1.5 to about 2% by weight; from about 2 to about 5% by weight, about 2 to about 4% by weight, from about 2 to about 3% by weight; from about 3 to about 5% by weight, from about 3 to about 4% by weight, or any range or subrange thereof, based on the total weight of the skin care composition. ;

[0090] Skin care compositions may comprise one or more amino acids. The amino acids may be selected from arginine, lysine, serine, citrulline, omithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, one of their salts or a combination of two or more of these.

[0091] The skin care composition may comprise one or more amino acids in an amount of about 0.01 to about 5% by weight based on the total weight of the skin care composition. In some embodiments, the skin care composition may include an amino acid in an amount of about 0.01 to about 2% by weight, about 0.01 to about 1.7% by weight, about 0.01 to about 1.4% by weight, about 0.01 to about 1.2% by weight, about 0.01 to about 1% by weight, about 0.01 to about 0.8% by weight, about 0.01 to about 0.6% by weight, about 0.01 to about 0.4% by weight, about 0.01 to about 0.2% by weight, about 0.01 to about 0.1% by weight, about 0.01 to about 0.05% by weight;from about 0.05 to about 3% by weight, from about 0.05 to about 2% by weight, from about 0.05 to about 1.7% by weight, from about 0.05 to about 1.4% by weight, from about 0.05 to about 1.2% by weight, from about 0.05 to about 1% by weight, from about 0.05 to about 0.8% by weight, from about 0.05 to about 0.6% by weight, from about 0.05 to about 0.4% by weight, from about 0.05 to about 0.2% by weight, from about 0.05 to about 0.1% by weight; from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1.7% by weight, from about 0.1 to about 1.4% by weight, from about 0.1 to about 1.2% by weight, from about 0.1 to about 1% by weight, from about 0.1 to about 0.8% by weight, from about 0.1 to about 0.6% by weight, from about 0.1 to about 0.4% by weight, from about 0.1 to about 0.2% by weight;from about 0.3 to about 3% by weight, from about 0.3 to about 2% by weight, from about 0.3 to about 1.7% by weight, from about 0.3 to about 1.4% by weight, from about 0.3 to about 1.2% by weight, from about 0.3 to about 1% by weight, from about 0.3 to about 0.8% by weight, from about 0.3 to about 0.6% by weight; from about 0.6 to about 3% by weight, from about 0.6 to about 2% by weight, from about 0.6 to about 1.7% by weight, from about 0.6 to about 1.4% by weight, from about 0.6 to about 1.2% by weight, from about 0.6 to about 1% by weight; from about 1 to about 3% by weight, from about 1 to about 2% by weight, from about 1 to about 1.7% by weight, from about 1 to about 1.4% by weight, from about 1 to about 1.2% by weight; from about 1.5 to about 3% by weight, from about 1.5 to about 2% by weight, from about 2 to about 3% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.;

[0092] The total amount of amino acid(s) present in the skin care composition may be from about 0.1 to about 7% by weight, based on the total weight of the skin care composition. For example, the total amount of amino acid(s) in the skin care composition may be from about 0.1 to about 6% by weight, from about 0.1 to about 5% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1.7% by weight, from about 0.1 to about 1.4% by weight, from about 0.1 to about 1.2% by weight, from about 0.1 to about 1% by weight, from about 0.1 to about 0.8% by weight, from about 0.1 to about 0.6% by weight, from about 0.1 to about 0.4% by weight, about 0.1 to about 0.2% by weight; from about 0.3 to about 7% by weight, from about 0.3 to about 5% by weight, from about 0.3 to about 3% by weight, from about 0.3 to about 2% by weight, from about 0.3 to about 1.7% by weight, from about 0.3 to about 1.4% by weight, from about 0.3 to about 1.2% by weight, from about 0.3 to about 1% by weight, from about 0.3 to about 0.8% by weight, from about 0.3 to about 0.6% by weight;from about 0.6 to about 7% by weight, from about 0.6 to about 5% by weight, from about 0.6 to about 3% by weight, from about 0.6 to about 2% by weight, from about 0.6 to about 1.7% by weight, from about 0.6 to about 1.4% by weight, from about 0.6 to about 1.2% by weight, from about 0.6 to about 1% by weight; from about 1 to about 7% by weight, from about 1 to about 5% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight, from about 1 to about 1.7% by weight, from about 1 to about 1.4% by weight, from about 1 to about 1.2% by weight; from about 1.5 to about 7% by weight, from about 1.5 to about 5% by weight, from about 1.5 to about 3% by weight, from about 1.5 to about 2% by weight; from about 2 to about 7% by weight, from about 2 to about 5% by weight, from about 2 to about 3% by weight;from about 3 to about 7% by weight, from about 3 to about 5% by weight, from about 4 to about 7% by weight, from about 4 to about 6% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.;

[0093] In certain preferred embodiments, the skin care composition comprises taurine, arginine and glycine or a combination of two or more thereof.

[0094] The skin care composition may be specifically formulated to contain taurine, arginine, and glycine in a taurine / arginine / glycine (taurine:arginine:glycine) weight ratio of (1.5 - 69):(0.5 - 40):(0.5 - 1.5), respectively. For example, the skin care composition may be formulated to have a weight ratio of taurine to arginine to glycine (taurine:arginine:glycine) of about 85:45:1 to about 45:24:1. In some embodiments, the skin care composition has a weight ratio of taurine to arginine to glycine of about 80:42:1 to about 50:30:1; about 75:40:1 to about 55:29:1; from about 70:37:1 to about 60:31:1, or any range or subrange thereof. In at least one embodiment, the skin care composition comprises a weight ratio of taurine, arginine, and glycine of about (65):(34):(1), respectively.

[0095] In at least one embodiment, the skin care composition comprises: • taurine, arginine and glycine, wherein the skin care composition has a weight ratio of taurine, arginine and glycine (taurine:arginine:glycine) of (1.5 - 69):(0.5 - 40):(0.5 - 1.5), respectively (e.g. in a weight ratio of about (65):(34):(1), respectively); • ergothioneine (EGT); • alpha-tocopherol; and • vitamin B3 / niacinamide.

[0096] In at least one embodiment, the skin care composition comprises: • taurine, arginine and glycine, wherein the skin care composition has a weight ratio of taurine, arginine and glycine (taurine:arginine:glycine) of (1.5 - 69):(0.5 - 40):(0.5 - 1.5), respectively (e.g. in a weight ratio of about (65):(34):(1), respectively); • ergothioneine (EGT); • alpha-tocopherol; and • pyrrolidone-carboxylic acid and / or one of its salts (e.g. sodium PCA).

[0097] In at least one embodiment, the skin care composition comprises: • taurine, arginine and glycine, wherein the skin care composition has a weight ratio of taurine, arginine and glycine (taurine:arginine:glycine) of (1.5-69):(0.5-40):(0.5-1.5), respectively (e.g., in a weight ratio of about (65):(34):(1), respectively); • ergothioneine (EGT); • T alpha-tocopherol; • pyrrolidone-carboxylic acid and / or one of its salts (e.g. sodium PCA); and • vitamin B3 / niacinamide.

[0098] In at least one embodiment, the skin care composition comprises: • ergothioneine (EGT); • T alpha-tocopherol; and • pyrrolidone-carboxylic acid and / or one of its salts (e.g. sodium PCA), • wherein the skin care composition has a weight ratio of alpha-tocopherol, EGT and pyrrolidone-carboxylic acid and / or a salt thereof (alpha-tocopherol: EGT: pyrrolidone-carboxylic acid and / or a salt thereof) of (0.5 - 2): (0.5 - 20): (0.5 - 20), respectively (e.g. 1:1:1) (e.g. 1:1:2) (e.g. 1:10: 10), the weight ratios being given relative to the % by weight of raw material of the ingredients.

[0099] In at least one embodiment, the skin care composition comprises: • ergothioneine (EGT); • alpha-tocopherol; and • niacinamide, • wherein alpha-tocopherol, EGT and niacinamide are in a weight ratio of (0.5 - 2):(0.5 - 20):(0.5 - 20), respectively (e.g. 1:1:1) (e.g. 1:1:2) (e.g. 1:1:3) (e.g. 1:2:1) (e.g. 1:3:1) (e.g. 2:1:1) and (e.g. 3:1:1), the weight ratios being given relative to the % by weight of raw material of the ingredients.

[0100] In at least one embodiment, the skin care composition comprises: • ergothioneine (EGT); • alpha-tocopherol; and • pyrrolidone-carboxylic acid and / or one of its salts (e.g. sodium PCA), • wherein the skin care composition has a weight ratio of alpha-tocopherol:EGT:pyrrolidone-carboxylic acid and / or a salt thereof (alpha-tocopherol:EGT:pyrrolidone-carboxylic acid and / or a salt thereof) of (50 - 250): (0.5 - 20): (50 - 250), respectively (e.g. 50:1:50, 50:1:100, 50:1:150, 50:1:200, 50: 1:250, 100:1:50, 100:1:100, 100:1:150, 100:1:200, 100:1:250, 150:1:50, 150:1:100, 150:1:150, 150:1:200, 150:1:250, 200:1:50, 200:1:100, 200:1:150, 200:1:200, 200:1:250, 250:1:50, 250:1:100, 250:1:150, 250:1:200, 250:1:250, or any range or sub-range thereof), the weight ratios being based on the % by weight of active substance of the ingredients.

[0101] In at least one embodiment, the skin care composition comprises: • ergothioneine (EGT); • alpha-tocopherol; and • niacinamide • wherein the skin care composition has a weight ratio of alpha-tocopherol to EGT to niacinamide (alpha-tocopherolEGT:niacinamide) of (50 - 250):(0.5 - 20):(100 - 500), respectively (e.g. 50:1:100, 50:1:150, 50:1:200, 50:1:250, 50:1:300, 50:1:350, 50:1:400, 50:1:450, 50:1:500, 100:1:100, 100:1:150, 100:1:200, 100:1:250, 100:1:300, 100:1:350, 100:1:400, 100:1:450, 100:1:500, 150:1:100, 150:1:150, 150:1:200, 150:1:250, 150:1:300, 150:1:350, 150:1:400, 150:1:450, 150:1:500, 200:1:100, 200:1:150, 200:1:200, 200:1:250, 200:1:300, 200:1:350, 200:1:400, 200:1:450, 200:1:500, 250:1:100, 250:1:150, 250:1:200, 250:1:250, 250:1:300, 250:1:350, 250:1:400, 250:1:450, 250:1:500, or any range or sub-range thereof), the weight ratios being based on the % by weight of active substance of the ingredients.

[0102] In at least one embodiment, the skin care composition comprises: • ergothioneine (EGT); • alpha-tocopherol; • niacinamide; and • pyrrolidone-carboxylic acid and / or one of its salts (e.g. PCA of sodium).

[0103] In at least one embodiment, the skin care compositions have a weight ratio of taurine, arginine, to glycine, niacinamide, camosine, and alpha-tocopherol of about 2:1:1:1 or 2:2:1:1, respectively.

[0104] In at least one embodiment, the skin care composition is formulated to have a weight ratio of alpha-tocopherol to EGT of about 6:1 to about 1:6. For example, the skin care composition may have a weight ratio of alpha-tocopherol to EGT of about 6:1 to about 1:6, about 5:1 to about 1:6, about 4:1 to about 1:6, about 3:1 to about 1:6, from about 2:1 to about 1:6, from about 1:1 to about 1:6; from about 6:1 to about 1:5, from about 5:1 to about 1:5, from about 4:1 to about 1:5, from about 3:1 to about 1:5, from about 2:1 to about 1:5, from about 1:1 to about 1:5; from about 6:1 to about 1:4, from about 5:1 to about 1:4, from about 4:1 to about 1:4, from about 3:1 to about 1:4, from about 2:1 to about 1:4, from about 1:1 to about 1:4; from about 6:1 to about 1:3, from about 5:1 to about 1:3, from about 4:1 to about 1:3, from about 3:1 to about 1:3, from about 2:1 to about 1:3, from about 1:1 to about 1:3; from about 6:1 to about 1:2, from about 5:1 to about 1:2, from about 4:1 to about 1:2, about 3:1 to about 1:2, about 2:1 to about 1:2, about 1:1 to about 1:2; from about 6:1 to about 1:1, about 5:1 to about 1:1, about 4:1 to about 1:1, about 3:1 to about 1:1, about 2:1 to about 1:1, about 1:1, or any range or subrange thereof.

[0105] Additionally or alternatively, the skin care compositions may be formulated to have a weight ratio of alpha-tocopherol to niacinamide and / or EGT to niacinamide of about 1:1 to about 1:11.In some embodiments, the skin care compositions have an alpha-tocopherol / niacinamide and / or EGT / niacinamide weight ratio of about 1:1 to about 1:11, about 1:1 to about 1:9, about 1:1 to about 1:7, about 1:1 to about 1:6, about 1:1 to about 1:5, about 1:1 to about 1:4, about 1:1 to about 1:3; about 1:2 to about 1:11, about 1:2 to about 1:9, about 1:2 to about 1:7, about 1:2 to about 1:6, about 1:2 to about 1:5, about 1:2 to about 1:4, about 1:2 to about 1:3; from about 1:3 to about 1:11, from about 1:3 to about 1:9, from about 1:3 to about 1:7, from about 1:3 to about 1:6, from about 1:3 to about 1:5, from about 1:3 to about 1:4, from about 1:3, or any range or subrange thereof.

[0106] According to one embodiment, the skin care compositions may be formulated to further comprise: pyrrolidone carboxylic acid and / or a salt thereof, optionally in an amount of between 0.05 and 3% by weight relative to the total weight of the skin care composition.

[0107] Additionally or alternatively, the skin care compositions may be formulated to have a weight ratio of alpha-tocopherol to pyrrolidone carboxylic acid and / or a salt thereof and / or EGT to pyrrolidone carboxylic acid and / or a salt thereof of about 1:1 to about 1:11. In some embodiments, the skin care compositions have a weight ratio of alpha-tocopherol to pyrrolidone carboxylic acid and / or a salt thereof and / or EGT to pyrrolidone carboxylic acid and / or a salt thereof of about 1:1 to about 1:11, about 1:1 to about 1:9, about 1:1 to about 1:7, about 1:1 to about 1:6, about 1:1 to about 1:5, about 1:1 to about 1:4, about 1:1 to about 1:3; from about 1:2 to about 1:11, from about 1:2 to about 1:9, from about 1:2 to about 1:7, from about 1:2 to about 1:6, from about 1:2 to about 1:5, from about 1:2 to about 1:4, from about 1:2 to about 1:3; from about 1:3 to about 1:11, from about 1:3 to about 1:9, from about 1:3 to about 1:7, from about 1:3 to about 1:6, from about 1:3 to about 1:5, from about 1:3 to about 1:4, from about 1:3, or any range or sub- range of these.

[0108] In some embodiments, the skin care compositions comprise a weight ratio of alpha-tocopherol, EGT, and pyrrolidone-carboxylic acid and / or a salt thereof (alpha-tocopherol:EGT:pyrrolidone-carboxylic acid and / or a salt thereof) of (0.5 - 2): (0.5 - 20): (1 - 20), respectively (e.g. 1:1:1) (e.g. 1:1:2) (e.g. 1:10:10), the weight ratios being based on the weights of the ingredients relative to the total weight of the composition. In other embodiments, the skin care composition comprises alpha-tocopherol, EGT and sodium PCA in a weight ratio of (50-250): (0.5-20): (50-250), respectively (e.g. 200:1:200), the weight ratios being based on the % by weight of active ingredient of the ingredients relative to the total weight of the composition. In some embodiments, the skin care composition may be formulated to have a weight ratio of alpha-tocopherol, EGT, and pyrrolidone carboxylic acid and / or a salt thereof (alpha-tocopherol:EGT:pyrrolidone carboxylic acid and / or a salt thereof) of about 1:2:6 to about 1:0.5:1.5, about 1:1.5:4 to about 1:0.75:2; about 1:1.1:3.3 to about 1:0.9:2.7.

[0109] In some embodiments, the skin care composition comprises a weight ratio of alpha-tocopherol, EGT, and niacinamide (alpha-tocopherol:EGT:niacinamide) in a weight ratio of (0.5 - 2):(1 - 20):(1 - 20), respectively (e.g., 1:1:1) (e.g., 1:1:2) (e.g., 1:1:3), wherein the weight ratios are based on the weight % of the raw materials of the ingredients relative to the total weight of the composition. In some embodiments, the skin care composition may be formulated to have a weight ratio of alpha-tocopherol, EGT, and niacinamide (alpha-tocopherol:EGT:niacinamide) of about 1:2:6 to about 1:0.5:1.5, about 1:1.5:4 to about 1:0.75:2; about 1:1.1:3.3 to about 1:0.9:2.7.In other embodiments, the skin care composition comprises a weight ratio of alpha-tocopherol, EGT, and niacinamide (alpha-tocopherol:EGTmiacinamide) in a weight ratio of (100-250):(0.5-5):(200-600) (e.g., 200:1:400), wherein the weight ratios are based on the % active ingredient weight of the ingredients.

[0110] In at least one embodiment, the skin care composition comprises: • niacinamide (e.g. 0.5% to 5% by weight of the composition) (e.g. about 3% by weight); • alpha-tocopherol (e.g. from 0.1% to 2% by weight of the composition) (e.g. about 0.5% by weight); and • ergothioneine (EGT) (e.g. 0.001 to 0.005% by weight of the composition) (e.g. about 0.0025% by weight).

[0111] In at least one embodiment, the skin care composition comprises: • ascorbyl glucoside (e.g. from 0.5% to 5% by weight of the composition) (e.g. about 2% by weight), the ascorbyl glucoside being present in a amount preferably ranging from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight; from about 2 to about 5% by weight, from about 2 to about 4% by weight, from about 2 to about 3% by weight; from about 3 to about 5% by weight, from about 3 to about 4% by weight, or any range or sub-range thereof, relative to the total weight of the skin care composition; and • astaxanthin (e.g. from 0.001% to 0.05% by weight of the composition) (e.g. about 0.01% by weight).

[0112] In at least one embodiment, the skin care composition comprises: • ergothioneine (EGT); • alpha-tocopherol; • niacinamide (vitamin B); • pyrrolidone-carboxylic acid and / or one of its salts (e.g. PCA of sodium); • hyaluronic acid (e.g. having a molecular weight of 50 kDa); • magnesium sulfate; and • nicotinamide adenine dinucleotide (NAD).

[0113] One or more thickening agents may be included in the skin care composition. The amount of thickening agent(s) in the skin care composition may be from about 0.1 to about 10% by weight, based on the total weight of the skin care composition. For example, the thickening agents may be present in the skin care compositions in an amount ranging from about 0.1 to about 9% by weight, from about 0.1 to about 8% by weight, from about 0.1 to about 7% by weight, from about 0.1 to about 6% by weight, from about 0.1 to about 5% by weight, from about 0.1 to about 4% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1% by weight; from about 0.1 to about 10% by weight.%, from about 0.1 to about 9% by weight, from about 0.1 to about 8% by weight, from about 0.1 to about 7% by weight, from about 0.1 to about 6% by weight, from about 0.1 to about 5% by weight, from about 0.1 to about 4% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1% by weight; from about 0.5 to about 10% by weight, from about 0.5 to about 9% by weight, from about 0.5 to about 8% by weight, from about 0.5 to about 7% by weight, from about 0.5 to about 6% by weight, from about 0.5 to about 5% by weight, from about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% more, from about 0.5 to about 1% by weight; from about 0.75 to about . 10% by weight, from about 0.75 to about 9% by weight, from about 0.75 to about 8% by weight, from about 0.75 to about 7% by weight, from about 0.75 to about 6% by weight, from about 0.75 to about 5% by weight, from about 0.75 to about 4% by weight, from about 0.75 to about 3% by weight, from about 0.75 to about 2% by weight; from about 1 to about 10% by weight, from about 1 to about 9% by weight, from about 1 to about 8% by weight, from about 1 to about 7% by weight, from about 1 to about 6% by weight, from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight; from about 1.5 to about 10% by weight, from about 1.5 to about 9% by weight, from about 1.5 to about 8% by weight, from about 1.5 to about 7% by weight, from about 1.5 to about 6% by weight, from about 1.5 to about 5% by weight, from about 1.5 to about 4% by weight, from about 1.5 to about 3% by weight;from about 2 to about 10% by weight, from about 2 to about 9% by weight, from about 2 to about 8% by weight, from about 2 to about 7% by weight, from about 2 to about 6% by weight, from about 2 to about 5% by weight, from about 2 to about 4% by weight; from about 3 to about 10% by weight, from about 3 to about 9% by weight, from about 3 to about 8% by weight, from about 3 to about 7% by weight, from about 3 to about 6% by weight, from about 3 to about 5% by weight; from about 4 to about 10% by weight, from about 4 to about 9% by weight, from about 4 to about 8% by weight, from about 4 to about 7% by weight, or from about 4 to about 6% by weight, including any range or subrange thereof, based on the total weight of the skin care composition.;

[0114] The thickening agent(s) may be selected from carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, gums, polysaccharides, and combinations of two or more thereof. Polysaccharides include cellulose, carboxymethylhydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylhydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof.

[0115] Non-limiting examples of carboxylic acid polymers include crosslinked carboxylic acid polymers containing one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids and substituted acrylic acids, such as carbomers. For example, the thickening agent(s) may include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, guar hydroxypropyltrimonium chloride, guar hydroxypropyltrimonium chloride, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, carboxymethyl dextran sodium, sodium carrageenan, tragacanth gum, xanthan gum, or a combination of two or more of these. In some embodiments, the thickening agent(s) may comprise or consist of one or more natural gums, such as those selected from xanthan gum, guar gum, biosaccharide gum, cellulose, acacia seneca gum, sclerotium gum, agarose, pechtin, gellan gum, hyaluronic acid, and a combination of two or more thereof.In some embodiments, the thickening agent comprises polyglycerides, including agar, agarose, pectin, guars, or a combination of two or more thereof.

[0116] In some cases, the skin care composition may be formulated to contain thickening agents selected from thickening polymers, such as polyvinyl alcohol, sodium polyacrylate, sodium polymethacrylate, polyacrylic acid glycerol ester, carboxyvinyl polymer, polyacrylamide, polyvinyl pyrrolidone, polyvinyl methyl ether, polyvinyl sulfone, maleic acid copolymer, polyethylene oxide, polydiallyl amine, polyethylene imine, water-soluble cellulose derivatives (e.g., carboxymethylcellulose, methylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, cellulose sulfate sodium salt), and / or starch derivatives (e.g., starch oxide, starch dialdehyde, dextrin, British gum, acetyl starch, starch phosphate, carboxymethyl starch, hydroxyethyl starch, hydroxypropyl starch).In some embodiments, the thickening agents are selected from hydroxypropylmethylcellulose, polyethylene glycols (PEG), polyacrylic acids, crosslinked homopolymer of acrylic acid, alkyl acrylate crosspolymer CiO_3o and a combination of two or more thereof.

[0117] Preferably, the thickening agent(s) comprise sodium polyacrylate, polyacrylate crosspolymer-6, cellulose, xanthan gum or a combination of two or more thereof. In at least one preferred embodiment, one or more thickening agents comprise or consist of sodium polyacrylate, polyacrylate crosspolymer-6, cellulose and xanthan gum.

[0118] The skin care composition generally comprises water in an amount of about 15 to about 60% by weight, based on the total weight of the composition. for skin care. For example, the total amount of water in the skin care composition may be about 15 to about 60% by weight, about 15 to about 55% by weight, about 15 to about 50% by weight, about 15 to about 46% by weight, about 15 to about 42% by weight, about 15 to about 38% by weight, about 15 to about 34% by weight; about 20 to about 60% by weight, about 20 to about 55% by weight, about 20 to about 50% by weight, about 20 to about 46% by weight, about 20 to about 42% by weight, about 20 to about 38% by weight, about 20 to about 34% by weight; from about 25 to about 60% by weight, from about 25 to about 55% by weight, from about 25 to about 50% by weight, from about 25 to about 46% by weight, from about 25 to about 42% by weight, from about 25 to about 38% by weight;from about 30 to about 60% by weight, from about 30 to about 55% by weight, from about 30 to about 50% by weight, from about 30 to about 46% by weight, from about 30 to about 42% by weight; from about 35 to about 60% by weight, from about 35 to about 55% by weight, from about 35 to about 50% by weight, from about 35 to about 46% by weight, from about 35 to about 42% by weight; from about 40 to about 60% by weight, from about 40 to about 55% by weight, from about 40 to about 50% by weight, from about 40 to about 46% by weight; from about 44 to about 60% by weight, from about 44 to about 55% by weight, from about 44 to about 50% by weight; from about 48 to about 60% by weight, from about 48 to about 55% by weight, from about 52 to about 60% by weight, or any range or subrange thereof, based on the total weight of the skin care composition.;

[0119] The skin care compositions may include one or more additional vitamins, such as vitamin C, vitamin D, and vitamin K. The additional vitamins may be individually present in the skin care composition in an amount of about 0.01 to about 5% by weight, based on the total weight of the skin care composition.In some cases, the amount of additional vitamins present in the skin care composition is about 0.01 to about 4% by weight, about 0.01 to about 3% by weight, about 0.01 to about 2% by weight, about 0.01 to about 1% by weight, about 0.01 to about 0.5% by weight, about 0.01 to about 0.1% by weight, about 0.01 to about 0.1% by weight; from about 0.1 to about 5% by weight, from about 0.1 to about 4% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1% by weight, from about 0.1 to about 0.5% by weight, from about 0.1 to about 0.1% by weight; from about 0.5 to about 5% by weight, from about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight, from about 0.5 to about 1%. by weight; from about 0.75 to about 5% by weight, from about 0.75 to about 4% by weight, from about 0.75 to about 3% by weight, from about 0.75 to about 2% by weight, from about 0.75 to about 1% by weight; from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2% by weight; from about 2 to about 5% by weight, from about 2 to about 4% by weight, from about 2 to about 3% by weight; from about 3 to about 5% by weight, from about 3 to about 4% by weight, including any intermediate range or sub-range, based on the total weight of the skin care composition.

[0120] As used herein, "vitamin C" may be ascorbic acid or its derivatives. Ascorbic acid exists as two enantiomers commonly referred to as "1" (for "levo") and "d" (for "dextro"). The "1" isomer is the most commonly encountered. Ascorbic acid is also referred to as L(+)-ascorbic acid or 1-ascorbic acid. Ascorbic acid derivatives may be or include, but are not limited to, L-ascorbic acid, calcium ascorbate, calcium ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L-ascorbyl phosphate (also known as: magnesium ascorbate phosphate or ascorbic acid phosphate magnesium salt), L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, sodium L-ascorbate (+), dehydro-l-(+)-ascorbic acid dimer, sodium ascorbyl phosphate (also known as: sodium ascorbic acid phosphate,1-ascorbyl sodium phosphate, 2-phospho-L-ascorbic acid trisodium salt, L-ascorbic acid 2-phosphate trisodium salt or L-ascorbyl-2-phosphate sodium), ascorbic acid-2-glucoside, ascorbyl dipalmitate, ascorbyl pectinate methylsilanol, ascorbyl stearate, disodium ascorbyl sulfate, 6-ascorbyl palmitate, calcium ascorbyl phosphate, ascorbyl acetate, ascorbyl propionate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl glucoside, ascorbic acid polypeptide, ascorbyl ethyl ether, pectinate of ascorbyl ethyl silanol, or the like, or combinations thereof.

[0121] As used herein, the term "vitamin D" refers to a group of fat-soluble secosteroids responsible for increasing the intestinal resorption of calcium, magnesium, and phosphate, as well as many other biological effects. The two main forms are vitamin D2 or ergocalciferol, and vitamin D3 or cholecalciferol. Vitamin D includes vitamin Di (a mixture of molecular compounds ergocalciferol and lumisterol), vitamin D2 (ergocalciferol), vitamin D3 (cholecalciferol), vitamin D4 (22-dihydroergocalciferol), and vitamin D5 (sitocalciferol).

[0122] As used herein, "vitamin K" is a group of compounds with the common chemical structure 2-methyl-1,4-naphthoquinone. Vitamin K plays a role in blood clotting, bone metabolism, and the regulation of blood calcium levels. Vitamin K includes vitamin Ki (phylloquinone) and vitamin K2 (menaquinone). Vitamin K2 generally has unsaturated isoprenylated side chains and is designated MK-4 to MK-13, depending on the length of its side chain.

[0123] Optionally, solvents may also be included in the skin care composition. The solvent(s) may include water-soluble alcohols, such as C2-8 alcohols, including ethanol; glycols, including propylene glycol, dipropylene glycol, tripropylene glycol, and mixtures thereof; glycerides, including mono-, di-, and triglycerides; medium- or long-chain organic acids, alcohols, and esters; surfactants, including emulsifying and dispersing agents; amino acids, including glycine; structuring agents, including thickening and gelling agents, e.g., polymers, silicates, and silicon dioxide; emollients; fragrances; and colorants, including dyes and pigments.

[0124] Other ingredients may be present in the skin care composition. These include ingredients for thickening, preserving, emulsifying, adding fragrance, adjusting pH, and coloring. For example, the skin care composition may include one or more emulsifiers, a pH adjuster, a colorant, a fragrance, a preservative, an antioxidant, emollients, or the like. The skin care compositions may include any of the following additional ingredients in an amount ranging from about 0.01 to about 5% by weight. In some cases, the amount of additional ingredients present in the skin care composition, individually or cumulatively, is about 0.01 to about 4% by weight, about 0.01 to about 3% by weight, about 0.01 to about 2% by weight, about 0.01 to about 1% by weight, about 0.01 to about 0.5% by weight, about 0.01 to about 0.1% by weight;from about 0.1 to about 5% by weight, from about 0.1 to about 4% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, from about 0.1 to about 1% by weight, from about 0.1 to about 0.5% by weight, from about 0.1 to about 0.1% by weight; from about 0.5 to about 5% by weight, from about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight, from about 0.5 to about 1% by weight; from about 0.75 to about 5% by weight, from about 0.75 to about 4% by weight, from about 0.75 to about 3% by weight, from about 0.75 to about 2% by weight, from about 0.75 to about 1% by weight; from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, from about 1 to about 2%; % by weight; from about 2 to about 5% by weight, from about 2 to about 4% by weight, from about 2 to about 3% by weight; from about 3 to about 5% by weight, from about 3 to about 4% by weight, including any intermediate range or sub-range, based on the total weight of the skin care composition.

[0125] Skin care compositions may contain one or more additional ingredients that are emollients. Non-volatile emollients are preferred. Non-volatile emollients include non-silicone emollients and silicone emollients. Non-volatile and non-silicone emollients include C1215 alkyl benzoate. The non-volatile silicone material may be a polyethersiloxane, a polyalkylarylsiloxane, or a polyethersiloxane copolymer. Phenyl trimethicone is an example of a non-volatile silicone material. Examples include, but are not limited to, PPG-14 butyl ether, PPG-3 myristyl ether, secondary alcohol ethoxylates, stearyl alcohol, stearic acid and its salts, glyceryl monoricinoleate, isobutyl palmitate, glyceryl monostearate, isocetyl stearate, sulfated tallow, oleyl alcohol, propylene glycol, isopropyl laurate, mink oil, sorbitan stearate,cetyl alcohol, hydrogenated castor oil, stearyl stearate, hydrogenated soybean glycerides, isopropyl isostearate, hexyl laurate, dimethyl brassylate, decyl oleate, diisopropyl adipate, n-dibutyl sebacate, diisopropyl sebacate, 2-ethyl hexyl palmitate, isononyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, 2-ethyl hexyl palmitate, 2-ethyl hexyl stearate, di-(2-ethyl hexyl)dipate, di-(2-ethyl hexyl)succinate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, octacosanol, butyl stearate, glyceryl monostearate, polyethylene glycols, oleic acid, triethylene glycol, acetylated lanolin alcohols, acetylated lanolin, petrolatum, lanolin isopropyl ester, fatty acids, butyl myristate, isostearic acid, palmitic acid, PEG-23 oleyl ether, oleyl oleate,isopropyl linoleate, cetyl lactate, lauryl lactate, myristyl lactate, hydroxyalkyl quaternized, aminogluconate, vegetable oils, isodecyl oleate, isostearyl neopentanoate, myristyl lemyristate, oleyl ethoxy myristate, diglycol stearate, ethylene glycol monostearate, myristyl stearate, isopropyl lanolate, paraffin waxes, glycyrrhizic acid, hydroxyethyl amide stearate, or a combination of two or more of these.

[0126] Skin care compositions may optionally include one or more additional ingredients that are antioxidants. For example, one or more antioxidants may be added to the composition to protect the ingredients and maintain long-term stability of the composition. Examples of optional antioxidants include, but are not limited to, citric acid, butylated hydroxytoluene, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate. In at least one embodiment, the antioxidants are selected from flavonoids, phytoalexins, camosine, ascorbic acid, tocotrienol, lipoic acid, a carotenoid, melatonin and a combination of two or more thereof.

[0127] Non-limiting examples of fragrances and perfumes include odorous compounds selected from: 7-acetyl-1,2,3,4,5,6,7,8-octahydro-1,1,6,7-tetramethylnaphthalene, α-ionone, [3-ionone, y-ionone α-isomethylionone, methylcedrylone, methyl dihydrojasmonate, methyl-1,6,10-trimethyl-2,5,9-cyclododecatriene-1-yl ketone, 7-acetyl-1,1,3,4,4,6-hexamethyltetraline, 4-acetyl-6-tert-butyl-1,1-dimethylindane, hydroxyphenylbutanone, benzophenone, methyl [3-naphthyl ketone, 6-acetyl-l,l,2,3,3,5-hexamethylindane, 5-acetyl-3-isopropyl-l,l,2,6-tetramethylindane, 1-dodecanal, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde, 7-hydroxy-3,7-dimethyloctanal, 10-undecene-l-al, isohexenylcyclohexylcarboxaldehyde, formyltricyclodecane, condensation products of hydroxycitronellal and methyl anthranilate, condensation products of hydroxycitronellal and indole,condensation products of phenylacetaldehyde and indole, 2-methyl-3-(para-tert-butylphenyl)propionaldehyde, ethylvanillin, heliotropin, hexylcinnamaldehyde, amylcinnamaldehyde, 2-methyl-2-(isopropylphenyl)propionaldehyde, coumarin, y-decalactone, cyclopentadecanolide, 16-hydroxy-9-hexadecenoic acid lactone, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-y-2-benzopyran, [3-naphthol] methyl ether, ambroxane, dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1b]furan, cedrol, 5-(2,2,3-trimethylcyclopen t-3-enyl)-3-methylpentan-2-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1 -yl)-2-buten-1-ol, caryophyllene alcohol, tricyclodecenyl propionate, tricyclodecenyl acetate, benzyl salicylate, cedryl acetate, tert-butylcyclohexyl acetate, and a combination of two or more of these.

[0128] Other fragrances may include odorous compounds selected from essential oils, resinoids, and resins from a variety of sources, such as, for example, Peruvian balsam, olibanum resinoid, styrax, labdanum resin, nutmeg, cassia oil, benzoin resin, coriander, and lavandin.

[0129] Other suitable fragrances include odorant compounds selected from phenylethyl alcohol, terpineol, linalool, linalool acetate, geraniol, nerol, 2-(1,1-dimethylethyl)cyclohexanol acetate, benzyl acetate and eugenol. The fragrances or perfumes may be used alone or in admixture with each other.

[0130] The skin care composition may also include one or more colorants. The colorants may be pigments, dyes, or mixtures thereof. Non-limiting examples of pigments include titanium dioxide, zinc oxide, kaolin, mica, etc. Non-limiting examples of colorants include food colorants suitable for food, pharmaceutical, and cosmetic applications, and mixtures thereof. Some coloring agents are known as FD&C dyes.

[0131] The colorants may be present in an amount ranging from about 0.0001 to about 0.4% by weight, inclusive of all percentages and sub-ranges, based on the total weight of the skin care composition. In some embodiments, the colorants may be present in an amount ranging from about 0.0001 to about 4% by weight, inclusive of all percentages and sub-ranges, based on the total weight of the skin care composition. In some embodiments, emulsifiers may be added to prevent the ingredients from separating.

[0132] In other embodiments, the skin care composition may include any of the following substances in any amount desired to achieve the desired effect in the composition (amounts that may be used in certain embodiments are indicated): one or more alkali salts, e.g., sodium chloride, sodium sulfate, sodium carbonate, sodium bicarbonate, and / or their equivalents (0-5% by weight); sequestrants, e.g., tetrasodium EDTA, and / or their equivalents (0-2% by weight); biocides, e.g., triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether), DMDM ​​hydantoin, formaldehyde, and / or imidazolidinyl urea, and / or their equivalents (0-2% by weight); organic acids, for example, citric acid and / or formic acid and / or their equivalents (0 to 2% by weight); viscosity modifiers (0 to 2% by weight); fragrances and / or perfumes (0 to 5% by weight);preservatives, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid (0 to 2% by weight); pearlitic agents, for example, distearic glycol esters, such as ethylene glycol distearate, but also monoglycol esters of fatty acids (0 to 3% by weight); stabilizers, for example, metal salts of fatty acids, such as, for example, magnesium stearate (0 to 3% by weight); stabilizers, for example, metal salts of fatty acids, such as, for example, ethylene glycol stearate (0 to 3% by weight), magnesium stearate, aluminum stearate and / or zinc stearate (0 to 2% by weight); and dyes and pigments approved and suitable for cosmetic use. In some embodiments, the preservatives may include one or more of citric acid, sodium lactate, sodium benzoate, benzoic acid, ; potassium sorbate, sodium phytate, ethanol or a combination of two or more of these.

[0133] The skin care composition may include one or more pH adjusters to increase or decrease the overall pH of the skin care composition. For example, one or more acids may be included to decrease the pH of the skin care composition. Examples of acids suitable for decreasing the pH of the skin care composition include, but are not limited to, citric acid, acetic acid, etc. The skin care composition may include one or more bases, such as sodium hydroxide, potassium hydroxide, and the like, to increase the pH of the skin care composition. Additional or alternative acids and bases suitable for adjusting the pH of the skin care composition are readily known to a person of ordinary skill in the art.

[0134] The amount of pH adjuster in the skin care composition may be based on the desired pH of the composition and / or the final skin care product. For example, the total amount of the pH builder may vary from about 0.05 to about 20% by weight, based on the total weight of the skin care composition. In some cases, the total amount of pH builder is from about 0.05 to about 15% by weight, from about 0.1 to about 10% by weight, or from about 0.12 to about 5% by weight, including intermediate ranges and sub-ranges, based on the total weight of the skin care composition.

[0135] In some embodiments, the skin care composition has a pH of about 4 to about 10.0. In other embodiments, the skin care composition has a pH of about 4.5 to about 8.0. In some embodiments, the skin care composition has a pH of about 5 to about 7.5. In other embodiments, the skin care composition has a pH of about 5.5 to about 7. In still other embodiments, the skin care composition has a pH of about 6 to about 7.

[0136] In some embodiments, the additional ingredient is selected from camosine, cica (asiaticoside), magnesium sulfate, saccharide isomerate, a keto-carotenoid (e.g., astaxanthin), nicotinamide adenine dinucleotide (NAD), and a combination of two or more thereof.

[0137] Anti-inflammatory agents may be included as additional ingredients in the skin care composition. The anti-inflammatory agent(s) may be selected from the group consisting of the following: dexamethasone, prednisolone, corticosterone, budesonide, sulfasalazine, mesalamine, cetirizine, diphenylhydramine, antipyrine, methyl salicylate, loratadine, thymol, carvacrol, bisabolol, allantoin, eucalyptol, phenazone, propyphenazone, a nonsteroidal anti-inflammatory drug (NSAID), and any combination of these.

[0138] Additionally or alternatively, the skin care composition may include one or more additional agents selected from anti-itching agents. Examples of anti-itching agents include methyl sulfonyl methane, sodium bicarbonate, calamine, allantoin, kaolin, peppermint, tea tree oil, camphor, menthol, and / or hydrocortisone.

[0139] In some embodiments, the skin care compositions may include additional ingredients selected from nonionic block copolymers. Examples of nonionic block copolymers include: poloxamer 338, poloxamer 407, poloxamer 237, poloxamer 217, poloxamer 124, poloxamer 184, poloxamer 185, or a combination of two or more thereof.

[0140] The skin care composition may optionally include a delivery vesicle [e.g. a multilamellar vesicle ("MLV"]. For example, the skin care composition may contain one or more ingredients encapsulated in a delivery vesicle, such as a multilamellar vesicle. The multilamellar vesicle may include liposome structuring agents comprising polyglyceryl-10 dioleate and at least one of polyglyceryl-10 dilinoleate or polyglyceryl-10 dipalmitate in a weight ratio of polyglyceryl-10 dioleate to at least one of polyglyceryl-10 dilinoleate or polyglyceryl-10 dipalmitate of between 300:1 and 5:1. In some cases, the multilamellar vesicle includes one or more ingredients selected from: polyglyceryl-10 dilinoleate, polyglyceryl-10 dipalmitate, polyglyceryl-10 dioleate, polyglyceryl-10, caprylic / capric triglyceride, and combinations thereof.The skin care composition may include a delivery vesicle when in the form of a transdermal injection (e.g., a mesotherapy composition).

[0141] Suspending agents such as silicas or clays such as bentonite, montmorillonite or hectorite, including those available under the trademark Bentone, may also be used to thicken liquid skin care compositions. The composition may be thickened using non-polymeric organic gelling agents, including selected dibenzylidene alditols (e.g. dibenzylidene sorbitol).

[0142] The skin care compositions of the disclosure may be made using methods known in the art. Generally, the ingredients are combined and optionally heated when the components are to be melted. The components are mixed. Preferably, volatile substances, such as fragrance substances, are incorporated into the composition during the final stages of the mixing cycle to prevent their volatilization. After mixing, the composition can be poured directly into the dispensers and the container capped to preserve the product until use.

[0143] The present disclosure provides, in another aspect, a skin care composition for use in inhibiting, treating, or reducing damage to the skin caused by reactive oxygen species. The skin care composition may be any of the skin care compositions disclosed herein.

[0144] The present disclosure provides, in another aspect, a method of inhibiting or reducing damage to the skin caused by reactive oxygen, wherein the method comprises administering to the skin an effective amount of one of the skin care compositions disclosed herein. The method may comprise the use of a skin care composition, wherein the skin care composition (e.g., one of the skin care compositions described herein) is administered by transdermal injection. Additionally or alternatively, the method may comprise the use of a skin care composition, wherein the skin care composition (e.g.,any skin care composition disclosed herein) is delivered topically to the skin using a serum, cream, moisturizer, mask, cleanser, oil, ointment, lotion, gel, salve, facial makeup paste, toner, essence, and balm (e.g., lip balm). EXAMPLES

[0145] Example 1

[0146] A non-limiting example of a skin care composition (Composition Example A) was prepared as a cream in accordance with certain aspects of the invention. The formulation of Composition Example A is shown in Table 1.

[0147] [Tableauxl] Compound name INCI Ex. A (% by weight) Water 43-48 Glycerin 11.9- 12.3 Propanediol, 5-5.2 Methylpropanediol and pentylene glycol 1.1 Ethyl oleate 7.8-8.1 Shea Butter (Butyrospermum parkii) 4.9 - 5.2 Cetyl Alcohol, Arachidyl Alcohol, Behenyl Alcohol and Stearyl Stearate 5.2 Magnesium Stearate 0.1-0.2 Hydrogenated Vegetable Oil, Zea mays (Corn) Oil and Rosa moschata Seed Oil 5 Dimethicone 0.9 - 1.3 Caprylic / Capric Triglyceride 0.1-0.2 Cera camauba / Copernicia cerifera (Carn auba) Wax / Cire de Camauba and Rhus ver niciflua peel cera 0.4 PEG-20 Castor Oil and PEG-60 Hydrogenated Castor Oil 0.3 Sodium Stearoyl Glutamate 1 Peanut Glucoside 0.4 - 0.6 Taurine 0.1-0.2 Cellulose and Xanthan Gum 1.6 Sodium Polyacrylate and Polyacrylate-C rosspolymer 6 0.9 Tocopherol 0.01 - 0.05 Tocopheryl Acetate 0.2 - 0.4 Sodium PCA 0.1-0.2 Ergothioneine 0.0001 -0.00 1 Niacinamide 0.15-0.3 Carnosine 0.1-0.2 Hydrolyzed Hyaluronic Acid 0.1-0.3 Arginine and Glycine 0.08 Adenosine 0.01 - 0.05 Polyglyceryl-10 Dipalmitate 0.1-0.3 Silybum Marianum Extract 0.01 - 0.05 Dipeptide diaminobutyroyl benzylamide diacetate 0.01 - 0.03 Mannitol 1 - 1.3 Magnesium sulfate 0.001 - 0.005 Nicotinamide adenine dinucleotide 0.001 - 0.005 Methylsilanol mannuronate 3.9 - 4.2 Calcium pantothenate 0.01 - 0.05 Inositol 0.01 - 0.05 Retinol 0.01 - 0.05 Acetyl tetrapeptide-11, acetyl tetrapeptide-9, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 0.003 Biotin 0.0001 -0.00 05 Haberlea rhodopensis leaf extract 0.01 - 0.05 Preservatives and buffering agents (citric acid, lactate sodium, sodium benzoate, benzoic acid, potassium sorbate, sodium phytate and ethanol) 1 Colorants 0.000067 Fragrance 0.5

[0148] Example 2

[0149] Composition Example A was clinically evaluated by cutometric evaluation, relief analysis and in vivo clinical evaluation. Thirty female volunteers aged 49 to 69 years and having healthy skin with wrinkles, fine lines, dullness, uneven tone, lack of firmness and crow's feet of grade 2 or higher, according to the scale described in Doublet, Atlas of Skin Aging, were selected for the evaluation of Composition Example A.

[0150] The volunteers underwent a product-free period of approximately two weeks before applying Composition Example A. After the product-free period, Composition Example A was applied twice daily, specifically once in the morning and once in the evening, for 28 days. The volunteers were evaluated prior to application of Composition Example A, the 7th day after application of Composition Example A and the 28th day after application of Composition Example A.

[0151] Cutometric evaluation

[0152] The cutometric evaluation was performed on the skin of the cheeks of each volunteer's face. Each volunteer underwent a 20-minute acclimation period in an air-conditioned room at a temperature of 21 ± 1.5 °C before the cutometric measurements. The same area of ​​skin was used for each of the cutometric measurements. The procedure for the cutometric measurements included the following steps: application of constant negative pressure, removal of the constraint, and a relaxation period. Inside the cutometer, a penetration depth was determined by a non-contact optical measuring system. This optical measuring system contained a light source and a light receiver, as well as two facing prisms, which projected light from the transmitter to the receiver. The intensity of the light varied depending on the depth of skin penetration.The skin's resistance to negative pressure (firmness) and its ability to return to its initial position (elasticity) were obtained and displayed as curves (penetration depth in mm / time) in real time.

[0153] Cutometric evaluation allows to measure the elastic and mechanical properties of the skin surface and to quantify skin aging objectively. The experimental conditions of the cutometric measurements were as follows: probe diameter: 2 mm; pressure: 300 mbar; on time: 2 s off time: 2 s repetition (number of cycles): 1. The cutometric measurements evaluated the following skin properties: net elasticity, skin length recovery speed, length of skin retraction after elongation and extent of skin length recovery.

[0154] Table 2 summarizes the results of the cutometric measurements at the initial evaluation before the application of Composition Example A, at the 7th day of application of Composition Example A and at the 28th day of application of Composition Example A.

[0155] [Tables2] Initial evaluation (D0) Evaluation on day 7 (D7) AJ7-D0 Evaluation on day 28 (D28) AJ28-D0 Net elasticity 0.496 0.528 7% 0.549 11% Skin length recovery rate 0.337 0.363 9% 0.375 13% Length of skin retraction after elongation 0.095 0.101 7% 0.107 14% Extent of skin length recovery 0.495 0.521 6% 0.535 9%

[0156] Relief analysis

[0157] The evaluation of the skin relief was carried out using a silicone skin replica using a silicone paste. The skin replica was taken from the subject's crow's feet wrinkles on the right or left (according to randomization). The skin replicas were then analyzed with the QU ANTIRIDES® software to analyze, quantify and characterize the wrinkles of a silicone resin impression. This software is specially designed to study the effectiveness of cosmetic products after treatment. The QU ANTIRIDES® software analyzes the images obtained and determines the different characteristics of the detected objects (relief): number of wrinkles, wrinkle depth, wrinkle length and wrinkle surface.

[0158] Table 3 summarizes the results of the relief measurements during the initial evaluation before the application of Composition Example A and at the 28th day of application of Composition Example A.

[0159] [Tables3] Initial assessment (D0) Assessment on day 28 (D28) AD28-D0 Number of wrinkles 108 80.5 -20% Surface area of ​​wrinkles 13.3 11.5 -14% Length of wrinkles 80.8 64.1 -18% Depth of wrinkles 86.4 89.9 4%

[0160] In vivo clinical evaluation

[0161] For the in vivo clinical evaluation, the skin of each volunteer was evaluated by an expert at the initial evaluation before the application of Composition Example A, at the 7th day of application of Composition Example A and at the 28th day of application of Composition Example A. Specifically, the skin of each volunteer was evaluated by assessing the appearance of the volunteer's crow's feet, the homogeneity of skin tone, the brightness of the skin and the firmness of the skin. The expert performed the evaluation by normalizing the position and illumination of the parameter using the dedicated scale, with lower numerical values ​​corresponding to a lower intensity of the parameter and numerical values ​​higher with greater intensity of said parameter.

[0162] A summary of the volunteer's assessment of crow's feet, skin tone homogeneity, skin brightness, and skin firmness is presented in Table 4.

[0163] [Tables4] Initial assessment (D0) Assessment on day 7 (D7) AJ7-D0 Assessment on day 28 (D28) AJ28-D0 Brightness 4.2 (± 1.3) 4.5 (± 1.2) 11% 4.7 (± 1.3) 16% Homogeneity 4.3 (± 1.2) 4.4 (± 1.2) 1% 4.6 (± 1.2) 6% Appearance of crow's feet 4(± 1.3) 3.9 (± 1.2) -2% 3.8 (± 1.4) -6% Skin firmness 4.7 (± 1.3) 4.8 (± 1.4) 3% 5 (± 1.4) 9%

[0164] Example 3

[0165] Composition Example A was clinically evaluated by macrophotography to assess cell turnover. Specifically, dihydroxyacetone (DHA) was applied to both forearms of each volunteer in Example 2 using a DHA patch. The DHA patch remained on the volunteers' arms for 4 hours. DHA is widely used in self-tanning products (e.g., sunless tanning), as application of DHA to the skin is known to cause the skin to turn brown. This coloration is due to interactions of DHA with amino acids in the skin. Without being limited to any particular theory, it is believed that DHA penetrates the stratum corneum, eventually reaching the upper layers of the stratum granulosum, and binds to the skin forming a DHA-skin complex (DHA-SC).Since DHA-SC is an integral part of the skin surface, its substantivity is limited only by natural skin desquamation or physical removal from corneocytes.

[0166] Measurements were taken on the part of the forearm receiving DHA and then Composition Example A and on the part of the other forearm receiving only DHA. Specifically, photographs of these two areas were taken before application of DHA (to obtain a baseline), after application of DHA but before application of Composition Example A, and on days 4, 5, 6 and 7 of application of Composition Example A. For each day of application, Composition Example A was applied once in the morning and once in the evening to the same area of ​​the forearm; the other forearm was used as a control area.

[0167] The absolute measurements were expressed as L*a*b*, where L* represents the relative brightness from total black (L*= 0) to total white (L*= 100); a* represents the balance between red and green; and b* represents the balance between yellow and blue. Using the absolute measurements, the following parameter was calculated for each area: AE = V (AU+Aa^Ab^:

[0168] color difference observed in an area, between two moments. AE is a measure of the visual difference between colors.

[0169] It was determined that there was a statistically significant decrease in the AE parameter on day 4, day 5, day 6 and day 7, for the forearm treated with the composition of Example A and the control forearm compared to the initial evaluation after skin coloring due to the application of DHA. With respect to the L parameter, there was also a statistically significant increase on day 4, day 5, day 6 and day 7, compared to the initial evaluation after skin coloring due to the application of DHA, indicating an increase in skin lightening. With respect to the b* parameter, there was a greater statistically significant decrease on the treated area on day 5, showing a better effect on skin pigmentation achieved by the Example A composition. Maintaining AE and ITA parameters indicates that skin color and pigmentation have been maintained.These results confirm the regenerating effect of Example A of composition after 7 days of application.

[0170] Example 4

[0171] Composition Example A was evaluated against two comparative compositions (Comparative Compositions 1 and 2) to evaluate the effectiveness of the respective compositions. The list of ingredients of Comparative Compositions 1 and 2 is provided below.

[0172] The list of ingredients of comparative composition 1 is provided below.

[0173] Water, Glycerin, Butyrospermum parkii (Shea) Butter, Propanediol, Polymethyl methacrylate, Methylsilanol mannuronate, Cetyl alcohol, Sodium potassium aluminum silicate, Dimethicone, Methylpropanediol, Sodium chloride, Phenoxyethanol, Butylene glycol, Hydroxyethylacrylate / sodium acryloyldimethyltaurate copolymer, Polyacrylate crosspolymer-6, Parfum (Fragrance), Ci 77891 (Titanium dioxide), Silica, Sucrose palmitate, Tocopheryl acetate, PEG-20 castor oil, Ethylhexyl salicylate, Chlorphenesin, Hydrolyzed hyaluronic acid, Alcohol Denat, Glucose, Disodium Edta, Glyceryl linoleate, Prunus amygdalus Dulcis (Sweet almond) oil, Butyl methoxydibenzoylmethane, potassium chloride, diethylhexyl syringylidenemalonate, carbomer, PEG-60 hydrogenated castor oil, Polysorbate 60, Sodium Lactate, Sorbitan Isostearate, Calcium Chloride, Zea Mays (Corn) Oil, Benzyl Alcohol, Sodium Hydroxide, Haberlea Rhodopensis Leaf Extract, Polysorbate 20, Magnesium Sulfate, Glutamine, Citric Acid, Inositol, Calcium Pantothenate, Retinol, Sodium Phosphate, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Sodium Hyaluronate, Sodium Citrate, Ascorbic Acid, Sodium Acetate, Sodium Benzoate, Soluble Collagen, Potassium Sorbate, Lysine HCl, Arginine HCl, Rosa Moschata Seed Oil, Alanine, Dehydroacetic Acid, Histidine HCl, Valine, Leucine, Threonine, Isoleucine, Tryptophan, Phenylalanine, Tyrosine, Glycine, Polysorbate 80, serine, cystine, cyanocobalamin, glutathione, asparagine, aspartic acid, ornithine HCl, glutamic acid, nicotinamide adenine dinucleotide, proline, biotin, methionine, taurine, hydroxyproline, glucosamine HCl, tocopherol, coenzyme A, palmitoyl tripeptide-1,Sodium glucuronate, palmitoyl tetrapeptide-7, thiamine diphosphate, Ci 17200 (Red 33), retinyl acetate, niacin, niacinamide, pyridoxine HCl, riboflavin, sodium tocopheryl phosphatr, thiamine HCl and folic acid.

[0174] A list of the ingredients of Comparative Composition 2 is provided below.

[0175] Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat., Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupin Protein, Pisum Sativum Extract / Pea Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Cera Alba / Beeswax, Orbignya Oleifera Seed Oil, Simmondsia Chinensis (Jojoba) Butter, Cetearyl Glucoside, Acid citric acid, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polysorbate 60, potassium cetyl phosphate, sorbitan isostearate, tocopherol, dimethicone / polyglycerin-3 crosspolymer, benzyl alcohol, geraniol,limonene, chlorphenesin, dipropylene glycol, phenoxyethanol, sodium benzoate and fragrance.

[0176] Specifically, oxidative species (ROS) reduction, elasticity, (ECM), ECM / DEJ, barrier, and vitality were evaluated for each of the compositions of Composition Example A and Comparative Compositions 1 and 2. A summary of the evaluation of Composition Example A and B versus Comparative Compositions 2-4 is shown in FIGURES 1-5. Specifically, [Fig.l] is a bar chart of the effect on oxidative species reduction. [Fig.2] is a bar chart of the effect on gene expression analysis, specifically DEJ QPCR. [Fig.3] is a bar chart of the effect on loricrin expression. [Fig.4] is a bar chart of the effect on ELOVLl expression, IVL, KLK5, KLK7 and TGM1. [Fig.5] is a bar graph of the effect on the expression of HBEGF, TGFB2 and FGF2.

Claims

Claims

1. A skin care composition comprising: hyaluronic acid or a salt thereof; a silicone-based surfactant; one or more peptides; an extract; and a fatty component.

2. The skin care composition of claim 1, wherein the hyaluronic acid or a salt thereof comprises hydrolyzed hyaluronic acid.

3. A skin care composition according to claim 1 or claim 2, wherein the silicone surfactant is selected from anionic silicone surfactants.

4. A skin care composition according to claim 1 or claim 2, wherein the silicone-based surfactant comprises methylsilanol mannuronate, hydroxyethylacetomonium PG-dimethicone, polyglyceryl lauryl polydimethylsiloxyethyl dimethicone, or a combination of two or more thereof.

5. A skin care composition according to any preceding claim, wherein the peptide(s) comprise dipeptide diaminobutyroyl benzylamide diacetate, acetyl tetrapeptide-11, acetyl tetrapeptide-9, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, or a combination of two or more thereof.

6. A skin care composition according to any preceding claim, wherein the one or more peptides comprise two or more peptides selected from the group consisting of dipeptide diaminobutyroyl benzylamide diacetate, acetyl tetrapeptide-11, acetyl tetrapeptide-9, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7.

7. A skin care composition according to any one of claims 1 to 5, wherein the peptide(s) comprise dipeptide diaminobutyroyl benzylamide diacetate, acetyl tetrapeptide-11, acetyl tetrapeptide-9, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7.

8. A skin care composition according to any preceding claim, wherein the extract comprises Haberlea rhodopensis leaf extract.

9. A skin care composition according to any preceding claim, wherein the fatty component comprises a fatty ester, a fatty alcohol, a fatty ether, an oil, a wax, or a combination of two or more thereof.

10. A skin care composition according to any preceding claim, wherein the fatty component is present in an amount of between 7 and 40% by weight, plus or minus 10%, based on the total weight of the skin care composition.

11. A skin care composition according to claim 9 or claim 10, wherein the fatty component comprises a fatty ester comprising stearyl stearate, dihydroabietyl behenate, octyldodecyl behenate, isocetyl behenate, isostearyl lactate, lauryl lactate, linoleyl lactate, oleyl lactate, isostearyl octanoate, isocetyl octanoate, octyl octanoate, decyl oleate, isocetyl isostearate, isocetyl laurate, isocetyl stearate, isodecyl octanoate, isodecyl oleate, isononyl isononanoate, isostearyl palmitate, acetyl methyl ricinoleate, octyl isononanoate, 2-ethylhexyl isononanoate, octyldodecyl erucate, oleyl erucate, ethyl palmitate, isopropyl palmitate, such as 2-ethylhexyl palmitate, 2-octyldecyl, alkyl myristates such as 2-octyldodecyl isopropyl myristate, isobutyl stearate,2-hexyldecyl laurate, isocetyl stearate, octyldodecyl stearate, or a combination thereof,

12. Cl. A skin care composition according to any one of claims 9 to 11, wherein the fatty component comprises a vegetable oil comprising sunflower oil, corn oil, Rosa moschata seed oil, soybean oil, pumpkin oil, hydrogenated vegetable oil, grape seed oil, sesame seed oil, hazelnut oil, apricot oil, macadamia oil, arara oil, castor oil, avocado oil, caprylic / capric acid triglycerides, jojoba oil and shea butter oil, or a combination thereof.

13. The skin care composition of claim 12, wherein the vegetable oil is selected from corn oil, Rosa moschata seed oil, hydrogenated vegetable oil, or a combination of two or more thereof.

14. A skin care composition according to any one of claims 9 to 11, wherein the fatty component comprises a linear or branched silicone oil.

15. A skin care composition according to any one of claims 9 to 11, wherein the fatty component comprises a wax selected from Rhus vemiciflua bark wax, Butyrospermum parkii butter, or a combination thereof.

16. A skin care composition according to any preceding claim further comprising one or more polyols, optionally in an amount of 4 to 32% by weight, plus or minus 10%, based on the total weight of the skin care composition.

17. The skin care composition of claim 16, wherein the one or more polyols comprise a plurality of polyols, the plurality of polyols comprising glycerin and one or more glycols.

18. The skin care composition of claim 17, wherein the glycol(s) comprises ethylene glycol, propylene glycol, butylene glycol, caprylyl glycol, hexylene glycol, diethylene glycol, dipropylene glycol, or a combination of two or more thereof.

19. A skin care composition according to any preceding claim further comprising: a non-ionic surfactant, optionally in an amount of 0.1 to 5% by weight, plus or minus 10%, based on the total weight of the skin care composition.

20. The skin care composition of claim 19, wherein the nonionic surfactant is selected from the group consisting of pegylated castor oils, polyglycerol esters, poloxamers, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, glucosides, and a combination of two or more thereof.

21.

22.

23.

24.

25.

26.

27.

28.

29.

30.

31. The skin care composition of claims 19 and 20, wherein the pegylated castor oil has a pegylated chain of 10 to 80. A skin care composition according to any one of claims 19 to 21, wherein the non-ionic surfactant comprises several pegylated castor oils. The skin care composition of claim 22, wherein the plurality of pegylated castor oils comprises PEG-60 hydrogenated castor oil and PEG-20 castor oil. A skin care composition according to any preceding claim further comprising: an amino acid component comprising ergothioneine. The skin care composition of claim 24, wherein the amino acid component further comprises taurine, arginine, glycine, or a combination of two or more thereof. The skin care composition of claim 24, wherein the amino acid component further comprises taurine, arginine and glycine. A skin care composition according to any preceding claim further comprising: vitamin B, optionally present in an amount of from 0.05 to 3% by weight, plus or minus 10%, based on the total weight of the skin care composition. The skin care composition of claim 27, wherein the vitamin B comprises niacinamide. A skin care composition according to any preceding claim further comprising: pyrrolidone carboxylic acid and / or a salt thereof, optionally in an amount of between 0.05 and 3% by weight based on the total weight of the skin care composition. The skin care composition of claim 29, wherein the skin care composition has a weight ratio of pyrrolidone carboxylic acid and / or a salt thereof to niacinamide of 1:1 to 1:

11. A skin care composition according to any one of claims 28 to 30, wherein the skin care composition The skin further includes alpha-tocopherol and has a weight ratio of alpha-tocopherol to niacinamide of 1:1 to 1:

11.

32. A skin care composition according to any preceding claim, wherein the water is present in an amount of 15 to 60% by weight, plus or minus 10%, based on the total weight of the skin care composition.

33. A method of reducing wrinkles and / or improving the elasticity, evenness, luminosity and / or firmness of the skin, comprising: applying to the skin a skin care composition according to any one of the preceding claims.

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