An oral liquid formulation of apixaban

Abstract

An oral liquid formulation of apixaban comprising a therapeutically effective amount of apixaban, a salt or prodrug thereof; one or more viscosifying agents; one or more buffering agents to provide a formulation pH of 3.5 to 4.5, and one or more pharmaceutically acceptable excipients. The present invention also relates to process of preparation of an oral liquid formulation of apixaban. The viscosifying agent may be sorbitol (10-500 mg / ml), the buffer may be citrate (0.5-50 mg / ml), further components include anti-foaming agents, thickening agents, humectants, sweetening agents, preservatives and flavourings.