Solid beverage composition and method for using same
By designing solid beverage compositions containing specific proportions of carbohydrates, glycerol, electrolytes, and sweeteners, the shortcomings of traditional beverages in terms of osmotic pressure and nutritional supplementation are addressed, achieving isotonicity, sugar-free properties, antioxidant effects, and health benefits, thereby enhancing athletic performance and taste.
Patent Information
- Application Number
- PCT/CN2025/111182
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-07-30
- Filing Date
- 2025-07-29
- Publication Date
- 2026-02-05
AI Technical Summary
Existing beverages, while replenishing body fluids and electrolytes, fail to achieve comprehensive benefits. Furthermore, the increasing demand for sugar-free beverages may lead to health problems due to improper osmotic pressure, and traditional sweeteners cannot meet the needs for low-calorie and health-promoting functions.
A solid beverage composition containing carbohydrates, glycerol, electrolytes (such as lactate and succinate), vitamins, and sweeteners (such as allulose) is prepared into a solid dosage form by uniformly mixing, adjusting the osmotic pressure within the isotonic range to provide nutritional supplementation and taste.
It achieves the effects of replenishing electrolytes and vitamins while maintaining water balance, improving athletic performance, meeting sugar-free requirements, providing antioxidant and health benefits, having a good taste, and matching the osmotic pressure of the human body for rapid electrolyte replenishment.
Smart Images

Figure PCTCN2025111182-APPB-I100001 
Figure PCTCN2025111182-APPB-I100002 
Figure PCTCN2025111182-APPB-I100003
Abstract
Description
Solid beverage compositions and their methods of use Technical Field
[0001] This invention belongs to the field of food, beverage or supplement technology, and specifically relates to a solid beverage composition. Background Technology
[0002] As people's living standards continue to improve, their consumption of beverages is increasing. Furthermore, people hope that existing beverages can achieve more comprehensive effects while replenishing body fluids and electrolytes.
[0003] Excessively high osmotic pressure may cause gastric retention, nausea, vomiting, and severe diarrhea in individuals with poor gastrointestinal function, as well as dehydration and electrolyte imbalances due to these side effects. Conversely, excessively low osmotic pressure may lead to low intestinal osmotic pressure, causing water to be absorbed into the intestinal wall cells, resulting in edema. Therefore, while ensuring that beverages can replenish body fluids and / or electrolytes and provide certain nutritional and health benefits, it is essential to control the beverage's osmotic range to make it suitable for a wider range of people.
[0004] Succinate can participate in the TCA cycle in the body, playing an important role in redox reactions, thereby promoting metabolism, improving athletic performance, relieving fatigue, and improving blood circulation. Lactate, as an important product and regulator in glycolysis, participates in energy metabolism and the regulation of cellular redox state during exercise, thereby improving athletic performance, promoting vasodilation, and regulating blood flow.
[0005] Furthermore, with people paying increasing attention to healthy eating, sugar-free beverages are gaining popularity. Allulose, as a novel sweetener, not only provides sweetness but also has low-calorie and blood sugar-regulating effects, as well as certain antioxidant and neuroprotective functions. Its safety has been recognized by countries including the United States, Japan, and South Korea. Allulose is a perfect substitute for sucrose. Summary of the Invention
[0006] In one aspect, the present invention provides a solid beverage composition comprising, by weight: 20-70% carbohydrates; 5-20% glycerol; 10-60% electrolytes; 0-8% vitamins, wherein the electrolytes comprise lactate and / or succinate and one or more selected from sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, phosphate, sulfate, citrate, and glycinate.
[0007] In some implementations, glycerin may be in powder form.
[0008] In some implementations, the carbohydrate is selected from one or more of high-fructose corn syrup, sucrose, fructose, maltodextrin, glucose, and allulose.
[0009] In some embodiments, the carbohydrate is one or more of glucose, sucrose, fructose, and allulose, comprising 30-60%. In some embodiments, the carbohydrate is glucose or sucrose, preferably glucose.
[0010] In some implementations, the carbohydrate is allulose.
[0011] In some embodiments, the electrolyte is 15-50% lactate and / or succinate and sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, sulfate, citrate, glycine salt or combinations thereof.
[0012] In some embodiments, the electrolyte is one or more of sodium chloride, sodium citrate, magnesium citrate, potassium chloride, calcium carbonate, zinc glycinate, sodium succinate, calcium lactate, magnesium succinate, magnesium lactate, zinc sulfate, and zinc lactate.
[0013] In some implementations, the electrolyte is 1-20% sodium succinate, 0-10% potassium chloride, 0-10% calcium lactate, 1-10% magnesium succinate, magnesium citrate or magnesium lactate, 0-5% zinc sulfate, zinc glycinate or zinc lactate.
[0014] In another aspect, the present invention provides a solid beverage composition comprising, by weight: 20-60% allulose; 5-20% glycerol; 10-60% electrolyte; 0-8% vitamin, wherein the electrolyte is selected from one or more of sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, phosphate, sulfate, citrate, and glycine.
[0015] In some implementations, the electrolyte is 20-50.5% sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, sulfate, citrate, glycine salt, or a combination thereof.
[0016] In some implementations, the electrolyte is one or more of sodium chloride, sodium citrate, magnesium citrate, magnesium sulfate, potassium chloride, potassium citrate, calcium carbonate, calcium citrate, zinc glycinate, and zinc sulfate.
[0017] In some implementations, the electrolyte is 5-20% sodium chloride or sodium citrate, 10-20% magnesium citrate or magnesium sulfate, 0-10% potassium chloride or potassium citrate, 0-5% calcium carbonate or calcium citrate, and 0-1% zinc glycinate or zinc sulfate.
[0018] In some embodiments, the solid beverage composition further comprises 0-2% of one or more sweeteners selected from acesulfame potassium, sucralose, mogrosides, steviol glycosides, tripotassium glycyrrhizate, sodium / calcium cyclohexylsulfamate, sorbitol, asparagine methyl ester acesulfame potassium, xylitol, erythritol, maltitol, and lactitol.
[0019] In some embodiments, the sweetener is one or more selected from mogrosides, steviol glycosides, sorbitol, xylitol, erythritol, maltitol, and lactitol. In some embodiments, the sweetener is mogrosides, steviol glycosides, or allulose, preferably steviol glycosides.
[0020] In some embodiments, the solid beverage composition further comprises 1-15% of an acidity regulator selected from one or more of citric acid, malic acid, fumaric acid, adipic acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, and phosphoric acid; 0-4% of an anti-caking agent selected from one or more of cream of tartar, calcium silicate, silicon dioxide, microcrystalline cellulose, tricalcium phosphate, and magnesium stearate; and 0-8% of a flavoring selected from one or more of vanilla flavoring, strawberry flavoring, cocoa flavoring, and orange flavoring.
[0021] In some embodiments, the acidity regulator is one or more of citric acid, malic acid, ascorbic acid, acetic acid, and phosphoric acid, at a concentration of 1-10%. In some embodiments, the acidity regulator is one or more of citric acid and malic acid, at a concentration of 1-5%.
[0022] In some embodiments, the anti-caking agent is one or more of 0-2% silica, microcrystalline cellulose, tricalcium phosphate, and magnesium stearate. In some embodiments, the anti-caking agent is one or more of silica and microcrystalline cellulose.
[0023] In some implementations, the flavoring is 0-6% of one or more of strawberry flavoring and orange flavoring.
[0024] In some implementations, the vitamin is selected from one or more of vitamin A, vitamin B, vitamin C, vitamin D, and vitamin E.
[0025] In some embodiments, the vitamin is 0-4% of one or more of vitamin B and vitamin C. In some embodiments, the vitamin is 0-1% of vitamin B3, 0-1% of vitamin B6, 0-1% of vitamin B12, and 0-2% of vitamin C.
[0026] In some embodiments, the osmolality of the solid beverage composition after reconstitution is 280-320 mosmol / kg. In some embodiments, the osmolality of the solid beverage composition after reconstitution is 285-310 mosmol / kg.
[0027] In some embodiments, the osmolality of the solid beverage composition after reconstitution is 290-300 mosmol / kg.
[0028] In another aspect, the present invention provides a method of using the solid beverage composition as described above, the method of use comprising administering the solid beverage composition to a subject in need at a dose of 5-40 g per day.
[0029] In some embodiments, the solid beverage composition is administered to the subject in need at an amount of 8-35 g per day. In some embodiments, the solid beverage composition is administered to the subject in need at amounts of 1-50 g, 5-40 g, 8-35 g, 10-30 g, or 15-20 g per day. In some embodiments, the solid beverage composition may be prepared as a solid dosage form or a liquid dosage form.
[0030] In some embodiments, the solid beverage composition comprises: 20-70%, preferably 30-60% carbohydrates; 8-15%, preferably 9-15% glycerol; 18-60%, preferably 20-50.5% or 20-45% electrolytes; 0-5%, preferably 0-4% vitamins; and 1-15%, preferably 1-10%, or 2-6% acidity regulators. In some embodiments, the solid beverage composition further comprises 0-4%, preferably 0-2% anti-caking agents. In some embodiments, the solid beverage composition further comprises 0-2%, preferably 0-1% sweeteners. In some embodiments, the solid beverage composition further comprises 0-8%, preferably 0-5% flavorings.
[0031] The solid beverage composition of this invention can replenish electrolytes and vitamins lost due to strenuous exercise or severe diarrhea, maintain electrolyte balance, and provide high nutritional and health benefits as well as a feeling of fullness. The glycerol in the composition has a strong hydrating effect, thus retaining body fluids; when combined with electrolytes, it simultaneously achieves ideal hydration and rapid electrolyte replenishment. The composition of this invention also has isotonic properties and significantly enhances taste and flavor. The lactate / succinate formulation of this invention can effectively enhance athletic performance, supporting athletes in high-intensity and long-duration training. The allulose formulation meets sugar-free requirements, not only increasing sweetness, reducing calories, and regulating blood sugar, but also possessing antioxidant and health-promoting functions. Attached Figure Description
[0032] Figure 1 shows the effect of different compositions on the forelimb strength of mice. Detailed Implementation
[0033] The present invention will now be further described with reference to preferred embodiments thereof. While the invention will be described in conjunction with preferred embodiments, it should be understood that they are not intended to limit the invention to these embodiments. Rather, the invention is intended to cover alternatives, modifications, and equivalents that may be included within the spirit and scope of the invention as defined in the claims. Furthermore, numerous specific details are set forth in the detailed description of the invention to provide a thorough understanding of the invention. However, it will be apparent to those skilled in the art that the invention may be practiced without these specific details. In other instances, well-known methods, procedures, components, and other features have not been described in detail so as not to unnecessarily obscure aspects of the invention.
[0034] As used herein, the term “or” is intended to include both “and” and “or”. In other words, the term “or” can also be replaced with “and / or”.
[0035] As used herein, unless the context clearly indicates otherwise, the singular forms “a / an” and “the” are intended to include the plural forms as well.
[0036] As used herein, the terms “comprising” or “including” or variations thereof refer to items that are included in the context of the term in their non-restrictive sense, but do not exclude items not specifically mentioned. It also includes the more restrictive verbs 'consistently composed of' and 'comprises of'.
[0037] The inventors have adjusted the composition and dosage of each component in the solid beverage composition to achieve ideal appearance, taste, balanced nutritional supplementation, and multiple effects such as isotonicity, enhanced exercise, and sugar-free properties.
[0038] The solid beverage composition of the present invention is simple and convenient to prepare; it only requires uniform mixing of the raw materials. In a preferred embodiment, the preparation method of the solid beverage composition of the present invention may include the following steps: Step 1, raw material sieving: all raw materials are sieved and set aside; Step 2, weighing: the materials in Step 1 are weighed according to the formula; Step 3, mixing: the materials are mixed using a mixing device to obtain the solid beverage composition. The solid beverage composition of the present invention can be packaged in PE bags for the inner packaging and in cardboard boxes for the outer packaging. In the preparation method of the present invention, some components can be added appropriately in the above steps depending on the properties of the raw materials.
[0039] Considering ease of consumption, the solid beverage composition of the present invention can be packaged in 16 g portions, which dissolve effectively with 450 mL of water during preparation; or in 10 g portions, which dissolve effectively with 280 mL of water during preparation; or packaged and prepared in other suitable amounts. The osmolality after preparation is 280-320 mosmol / kg, preferably 290-300 mosmol / kg, which is within the isotonic range and the same as the osmolality of the human body. This allows it to directly replenish electrolyte losses in body fluids, promoting rapid balance of water, salt, acid-base, and osmolality within the body. It also has a strong hydration effect, thus maintaining body hydration, helping the body quickly eliminate fatigue, restore physical strength, and maintain optimal condition, meeting the body's needs. Furthermore, the resulting product exhibits a better taste, better palatability, uniform appearance, excellent stability, and a good balance of solubility, without problems such as clumping, moisture absorption, or agglomeration. In addition, the solid beverage composition of the present invention can also enhance exercise and meet sugar-free requirements.
[0040] The technical features, implementation methods, and beneficial effects of the present invention will be further described in detail below with reference to specific implementation examples. The embodiments described below are only some embodiments of the present invention, and not all embodiments. Unless otherwise specified, the materials and reagents described in the following embodiments are all commercially available products that can be purchased from the market. Example Preparation of solid beverage compositions Example 1
[0041] Step 1: Sift the following ingredients: Vitamin C, Vitamin B, Sodium Succinate, Potassium Chloride, Calcium Lactate, Magnesium Citrate, Zinc Glycine, Glycerin Powder, Citric Acid, and Glucose through a 20-mesh sieve to obtain a fine powder for later use.
[0042] Step 2, Weigh the following materials sieved in Step 1: 100 g Vitamin C, 50 g Vitamin B, 2500 g Sodium Succinate, 700 g Potassium Chloride, 900 g Calcium Lactate, 2500 g Magnesium Citrate, 20 g Zinc Glycine, 2000 g Glycerin Powder, 400 g Citric Acid, and 10000 g Glucose. Set aside.
[0043] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 40 minutes to obtain the solid beverage composition of Example 1. Example 2
[0044] Step 1: Sift the following ingredients: Vitamin C, Vitamin B, Sodium Succinate, Potassium Chloride, Calcium Lactate, Magnesium Lactate, Zinc Sulfate, Glycerin Powder, Citric Acid, Glucose, Stevia Glycoside, Silicon Dioxide, and Sweet Orange Flavor. Sift through a 20-mesh sieve to obtain a fine powder for later use.
[0045] Step 2, Weigh the following materials sieved in Step 1: 150 g Vitamin C, 60 g Vitamin B, 3000 g Sodium Succinate, 750 g Potassium Chloride, 950 g Calcium Lactate, 900 g Magnesium Lactate, 20 g Zinc Sulfate, 2500 g Glycerin Powder, 300 g Citric Acid, 8500 g Glucose, 30 g Steviosides, 150 g Silicon Dioxide, and 150 g Sweet Orange Flavor. Set aside.
[0046] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 2. Example 3
[0047] Step 1: Sift the following ingredients: Vitamin C, Vitamin B6, Vitamin B12, Sodium Succinate, Potassium Chloride, Calcium Lactate, Magnesium Lactate, Zinc Sulfate, Glycerin Powder, Citric Acid, Glucose, Stevioside, Silicon Dioxide, and Strawberry Flavor. Sift through a 20-mesh sieve to obtain a fine powder for later use.
[0048] Step 2: Weigh the following materials sieved in Step 1: 150 g Vitamin C, 50 g Vitamin B6, 10 g Vitamin B12, 3000 g Sodium Succinate, 750 g Potassium Chloride, 950 g Calcium Lactate, 1600 g Magnesium Lactate, 30 g Zinc Sulfate, 2500 g Glycerin Powder, 300 g Citric Acid, 7700 g Glucose, 25 g Steviosides, 100 g Silicon Dioxide, and 200 g Strawberry Flavor. Set aside.
[0049] Step 3, mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 3. Example 4
[0050] Step 1: Sift the following ingredients through a 20-mesh sieve: Vitamin C, Vitamin B, Sodium Succinate, Potassium Chloride, Calcium Lactate, Magnesium Lactate, Zinc Sulfate, Glycerin Powder, Citric Acid, and Allulose. The resulting powder is ready for use.
[0051] Step 2, Weigh the following materials sieved in Step 1: 150 g Vitamin C, 60 g Vitamin B, 3000 g Sodium Succinate, 750 g Potassium Chloride, 950 g Calcium Lactate, 900 g Magnesium Lactate, 20 g Zinc Sulfate, 2500 g Glycerin Powder, 300 g Citric Acid, and 8500 g Allulose. Set aside.
[0052] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 4. Example 5
[0053] Step 1: Sift the following ingredients through a 20-mesh sieve: Vitamin C, Vitamin B, Sodium Succinate, Potassium Chloride, Calcium Lactate, Magnesium Succinate, Zinc Sulfate, Glycerin Powder, Citric Acid, and Allulose. The resulting powder is ready for use.
[0054] Step 2, Weigh the following materials sieved in Step 1: 150 g Vitamin C, 60 g Vitamin B, 3000 g Sodium Succinate, 750 g Potassium Chloride, 950 g Calcium Lactate, 1600 g Magnesium Succinate, 30 g Zinc Sulfate, 2500 g Glycerin Powder, 400 g Citric Acid, and 8000 g Allulose. Set aside.
[0055] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 5. Example 6
[0056] Step 1: Sift the following ingredients: Vitamin C, Vitamin B, Sodium Chloride, Sodium Citrate, Potassium Chloride, Calcium Carbonate, Magnesium Citrate, Zinc Sulfate, Glycerin Powder, Citric Acid, and Glucose through a 40-mesh sieve to obtain a fine powder for later use.
[0057] Step 2: Weigh the following materials sieved in Step 1: 150 g Vitamin C, 60 g Vitamin B, 1300 g Sodium Chloride, 1500 g Sodium Citrate, 750 g Potassium Chloride, 450 g Calcium Carbonate, 2500 g Magnesium Citrate, 30 g Zinc Sulfate, 2000 g Glycerin Powder, 250 g Citric Acid, and 6500 g Glucose. Set aside.
[0058] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 6. Example 7
[0059] Step 1: Sift the following ingredients through a 40-mesh sieve: Vitamin C, Vitamin B, Sodium Chloride, Sodium Citrate, Potassium Chloride, Calcium Carbonate, Magnesium Citrate, Zinc Sulfate, Glycerin Powder, Citric Acid, and Allulose. The resulting powder is ready for use.
[0060] Step 2, Weigh the following materials sieved in Step 1: 150 g Vitamin C, 60 g Vitamin B, 1300 g Sodium Chloride, 1500 g Sodium Citrate, 750 g Potassium Chloride, 450 g Calcium Carbonate, 2500 g Magnesium Citrate, 30 g Zinc Sulfate, 2000 g Glycerin Powder, 400 g Citric Acid, and 6500 g Allulose. Set aside.
[0061] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 7. Example 8
[0062] Step 1: Sift the following ingredients through a 40-mesh sieve: Vitamin C, Vitamin B, Sodium Chloride, Potassium Chloride, Calcium Citrate, Magnesium Sulfate, Zinc Glycine, Glycerin Powder, Citric Acid, and Allulose. The resulting powder is ready for use.
[0063] Step 2, Weigh the following materials sieved in Step 1: 150 g Vitamin C, 60 g Vitamin B, 3000 g Sodium Chloride, 750 g Potassium Chloride, 200 g Calcium Citrate, 500 g Magnesium Sulfate, 30 g Zinc Glycine, 2000 g Glycerin Powder, 300 g Citric Acid, and 6500 g Allulose. Set aside.
[0064] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 8. Example 9
[0065] Step 1: Sift the following ingredients: Vitamin C, Vitamin B, Sodium Chloride, Potassium Chloride, Calcium Carbonate, Magnesium Sulfate, Zinc Glycine, Glycerin Powder, Malic Acid, Citric Acid, Erythritol, Sweet Orange Flavor, and Stevia Glycosides through a 20-mesh sieve to obtain a fine powder for later use.
[0066] Step 2: Weigh the following materials sieved in Step 1: 50 g Vitamin C, 50 g Vitamin B, 2000 g Sodium Chloride, 500 g Potassium Chloride, 100 g Calcium Carbonate, 100 g Magnesium Sulfate, 10 g Zinc Glycinate, 1000 g Glycerin Powder, 5500 g Erythritol, 300 g Citric Acid, 300 g Malic Acid, 200 g Sweet Orange Flavor, and 30 g Stevia Glycosides. Set aside.
[0067] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 9. Example 10
[0068] Step 1: Sift the following ingredients: Vitamin C, Vitamin B, Sodium Chloride, Potassium Citrate, Calcium Citrate, Magnesium Citrate, Zinc Glycine, Glycerin Powder, Malic Acid, Citric Acid, Erythritol, Sweet Orange Flavor, and Monk Fruit Extract. Sift through a 20-mesh sieve to obtain a fine powder for later use.
[0069] Step 2: Weigh the following materials sieved in Step 1: 50 g Vitamin C, 50 g Vitamin B, 3000 g Sodium Chloride, 1000 g Potassium Citrate, 300 g Calcium Citrate, 200 g Magnesium Citrate, 20 g Zinc Glycine, 1500 g Glycerin Powder, 6500 g Erythritol, 300 g Citric Acid, 300 g Malic Acid, 200 g Sweet Orange Flavor, and 30 g Monk Fruit Extract. Set aside.
[0070] Step 3, Mixing: Combine the ingredients from Step 2 using a three-dimensional mixing device for 30 minutes to obtain the solid beverage composition of Example 10. Example 11: Permeability Test
[0071] The osmotic pressure of the solid beverage composition of the above embodiments and commercially available competing beverages was tested using the osmolarity determination method of the 2016 edition of the Chinese Standard Operating Procedures for Drug Inspection.
[0072] Sample preparation: Weigh a certain amount of sample and prepare a solution of the corresponding concentration.
[0073] Osmotic pressure determination: Take 100 μl (±10%) of the above solution and put it into the sample tube. Lift the measuring probe of the freezing point permeameter, place the sample tube on the sample needle, and make sure that no air bubbles are generated in the sample tube when adding the sample. Press the sample probe, enter the sample name, confirm and the sample will be automatically measured, and the result will be printed and recorded.
[0074] The osmotic pressure data of the solid beverage composition of this invention are shown in the table below:
[0075]
[0076] The osmotic pressure of the solid beverage compositions in Examples 2, 4, and 5 of this invention is all in the range of 280-320 mosmol / kg, with Examples 4 and 5 even reaching 290-300 mosmol / kg. The osmotic pressure of human body fluids is approximately 280-320 mosmol / L, while the osmotic pressure of commercially available competing products 1-4 is in the range of 196-271 mosmol / kg, and most of them do not achieve the ideal isotonic effect.
[0077] The solid beverage composition of this invention is isotonic, with the same osmotic pressure as the human body, and can directly replenish the loss of electrolytes in body fluids, promoting the rapid balance of water, salt, acid and alkali and osmotic pressure in the body. Example 12 Stability Test
[0078] Accelerated stability tests were conducted on Examples 2 and 4 according to the guidelines for stability testing in the Chinese Pharmacopoeia. The test results are as follows:
[0079]
[0080] The results show that all quality indicators of the formulated composition remained stable, demonstrating good stability. Example 13: Athletic Performance Test
[0081] Forty 8-week-old male ICR mice were purchased from Nanjing Wukong Biotechnology Co., Ltd. The mice were housed in an environment with four mice per cage, maintained at 23 ± 2℃ and 55 ± 5% humidity, with a 12-hour light-dark cycle, to allow them to acclimatize for one week. The mice had free access to water and food. Each group of mice was housed individually in standard cages. The experimental groups were as follows: the 40 mice were randomly divided into 5 groups (n=8) and treated for 4 weeks according to the following protocol: control group, and experimental groups (Examples 2, 4, 6, and 9), as shown in the table below:
[0082]
[0083] Forelimb grip strength test in mice: Forelimb grip strength was measured weekly using a stainless steel grid to assess muscle strength. Grip strength was measured 1 hour after drug administration. In brief, each mouse was first placed in the testing chamber for 10 minutes to acclimatize. Then, each mouse was placed on top of the grid of the grip strength meter, ensuring the mouse's forepaws were fully on the grip support. The mouse was gripped by the base of its tail, avoiding pressure on the grid. The animal was then gently pulled backward from the grid via its tail, along the axis of the grip strength measurement. The pull was slow enough to allow the mouse to resist the pull, and once the mouse released the grid, the score (gf) displayed on the grip strength measurement screen was recorded. Each animal underwent three independent trials, and the average of the three trials was calculated and recorded.
[0084] Figure 1 shows the effects of different embodiments on the forelimb strength of mice. As can be seen from the figure, after administering Examples 2, 4, 6, and 9 to mice, the forelimb grip strength of the mice was improved to varying degrees compared to the control group. Examples 2 and 4 showed significant strength increases after one week of administration, with increases of approximately 48.1% and 29.6% compared to Example 6, and approximately 42.9% and 25.0% compared to Example 9, respectively. This effect lasted for four weeks compared to the control group, and in the fourth week, Examples 2 and 4 showed an increase of approximately 32% compared to Example 6, and an increase of 37.5% compared to Example 9. It can be seen that adding succinate and lactate is more effective than adding citrate and chloride because succinate can participate in the TCA cycle in the body, promote metabolism, and play an important role in redox reactions, thereby improving athletic ability and performance; lactate, as an important product and regulator in glycolysis, participates in energy metabolism and the regulation of cellular redox state during exercise, thus improving athletic ability and performance. The solid beverage composition of this invention has a strong hydrating effect, effectively maintaining the body's water content. Its isotonic effect allows for rapid and effective electrolyte replenishment, while significantly enhancing athletic performance. Furthermore, it provides sweetness while being low in calories and sugar.
[0085] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any person skilled in the art can make various changes, modifications, substitutions and variations to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the claims and their equivalents.
Claims
1. A solid beverage composition, characterized in that, The solid beverage composition comprises, by weight: 20-70% carbohydrates; 5-20% glycerol; 10-60% electrolytes; and 0-8% vitamins, wherein the electrolytes comprise lactate and / or succinate and one or more selected from sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, phosphate, sulfate, citrate, and glycine.
2. The solid beverage composition according to claim 1, characterized in that, The carbohydrate is selected from one or more of high fructose corn syrup, sucrose, fructose, maltodextrin, glucose, and allulose.
3. The solid beverage composition according to claim 1 or 2, characterized in that, The carbohydrate is one or more of glucose, sucrose, fructose, and allulose, comprising 30-60% of the total carbohydrate.
4. The solid beverage composition according to any one of claims 1 to 3, characterized in that, The carbohydrate is allulose.
5. The solid beverage composition according to any one of claims 1 to 4, characterized in that, The electrolyte is 15-50% lactate and / or succinate and sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, sulfate, citrate, glycine salt or a combination thereof.
6. The solid beverage composition according to any one of claims 1 to 5, characterized in that, The electrolyte is 1-20% sodium succinate, 0-10% potassium chloride, 0-10% calcium lactate, 1-10% magnesium succinate, magnesium citrate or magnesium lactate, 0-5% zinc sulfate, zinc glycinate or zinc lactate.
7. A solid beverage composition, characterized in that, The solid beverage composition comprises, by weight: 20-60% allulose; 5-20% glycerol; 10-60% electrolyte; and 0-8% vitamin, wherein the electrolyte is selected from one or more of sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, phosphate, sulfate, citrate, and glycine.
8. The solid beverage composition according to claim 7, characterized in that, The electrolyte is 20-50.5% sodium, potassium, chloride, calcium, magnesium, zinc, carbonate, sulfate, citrate, glycine salt or a combination thereof.
9. The solid beverage composition according to claim 7 or 8, characterized in that, The electrolyte is 5-20% sodium chloride or sodium citrate, 10-20% magnesium citrate or magnesium sulfate, 0-10% potassium chloride or potassium citrate, 0-5% calcium carbonate or calcium citrate, and 0-1% zinc glycinate or zinc sulfate.
10. The solid beverage composition according to any one of claims 1 to 9, characterized in that, The solid beverage composition further comprises 0-2% of one or more sweeteners selected from the following: acesulfame potassium, sucralose, mogroside, steviol glycoside, tripotassium glycyrrhizate, sodium / calcium cyclohexylsulfamate, sorbitol, asparagine methyl ester acesulfame potassium, xylitol, erythritol, maltitol, and lactitol.
11. The solid beverage composition according to claim 10, characterized in that, The sweetener is one or more of the following: mogroside, steviol glycoside, sorbitol, xylitol, erythritol, maltitol, and lactitol, at a concentration of 0-1.5%.
12. The solid beverage composition according to any one of claims 1 to 11, characterized in that, The solid beverage composition further comprises 1-15% of an acidity regulator selected from one or more of citric acid, malic acid, fumaric acid, adipic acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, and phosphoric acid; 0-4% of an anti-caking agent selected from one or more of cream of tartar, calcium silicate, silicon dioxide, microcrystalline cellulose, tricalcium phosphate, and magnesium stearate; and 0-8% of a flavoring selected from one or more of vanilla flavoring, strawberry flavoring, cocoa flavoring, and orange flavoring.
13. The solid beverage composition according to claim 12, characterized in that, The acidity regulator is one or more of citric acid, malic acid, ascorbic acid, acetic acid, and phosphoric acid, at a concentration of 1-10%.
14. The solid beverage composition according to claim 12 or 13, characterized in that, The anti-caking agent is one or more of the following: 0-2% silica, microcrystalline cellulose, tricalcium phosphate, and magnesium stearate.
15. The solid beverage composition according to any one of claims 12 to 14, characterized in that, The flavoring is one or more of strawberry flavoring and orange flavoring, at a concentration of 0-6%.
16. The solid beverage composition according to any one of claims 1 to 15, characterized in that, The vitamins are selected from one or more of vitamins A, B, C, D, and E.
17. The solid beverage composition according to any one of claims 1 to 16, characterized in that, The vitamins mentioned are 0-1% vitamin B3, 0-1% vitamin B6, 0-1% vitamin B12, and 0-2% vitamin C.
18. The solid beverage composition according to any one of claims 1 to 17, characterized in that, The osmolar concentration of the solid beverage composition after reconstitution is 280-320 mosmol / kg.
19. The solid beverage composition according to claim 18, characterized in that, The osmolality of the solid beverage composition after reconstitution is 290-300 mosmol / kg.
20. A method of using a solid beverage composition as described in any one of claims 1 to 19, characterized in that, The method of use includes administering the solid beverage composition to the subject in need at a dose of 5-40 g per day.
21. The method of use according to claim 20, characterized in that, The solid beverage composition was administered to the subjects in need at a dose of 8-35 g per day.
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