Novel, reversible dpp1 inhibitors and uses thereof
Pharmaceutical compositions with compounds of formula (I) enhance the efficacy and specificity of DPP1 inhibitor treatments by modulating DPP1 activity, addressing limitations in current therapies.
HK40135097APending Publication Date: 2026-07-17INSMED INC
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- INSMED INC
- Filing Date
- 2026-04-29
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Current treatments for diseases treated by DPP1 inhibitors are limited in efficacy and specificity, necessitating the development of more effective pharmaceutical compositions that target DPP1 inhibitors.
Method used
Pharmaceutical compositions comprising compounds of formula (I) or their pharmaceutically acceptable salts or deuterated forms, which are designed to treat diseases by modulating DPP1 activity.
Benefits of technology
The compounds provide enhanced therapeutic efficacy and specificity in treating diseases targeted by DPP1 inhibitors.
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Smart Images
Figure 00000144_0000
Abstract
Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts or deuterated forms thereof, wherein R0 , L and R1 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt or deuterated form thereof, e.g., in the treatment of a disease that is treatable by administration of a DPP1 inhibitor.
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