Piperidinyl indole derivative, preparation method therefor and use thereof

Piperidinindole derivatives are designed to modulate the complement bypass pathway, addressing the inadequacies of existing treatments for diseases mediated by complement factor B dysregulation, providing therapeutic efficacy.

HK40135216APending Publication Date: 2026-07-17HEBEI YILING MEDICINE INST
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
HEBEI YILING MEDICINE INST
Filing Date
2026-06-10
Publication Date
2026-07-17
Patent Text Reader

Abstract

The present application provides a piperidinyl indole derivative, a preparation method and application thereof, in particular, the present application provides a compound with structural formula A and I or a pharmaceutically acceptable form thereof, which can be used for preparing a drug for treating a disease or disorder mediated by a disorder of a complement bypass pathway, in particular, a drug for treating a disease or disorder mediated by complement factor B.
Need to check novelty before this filing date? Find Prior Art

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202480069167.5 (22) Application Date 2024.12.16 (66) Domestic Priority Data 202410033993.6 2024.01.10 CN (85) PCT International Application Entering National Phase Date 2026.04.28 (86) PCT International Application Application Data PCT / CN2024 / 139628 2024.12.16 (87) PCT International Application Publication Data WO2025 / 148628 ZH 2025.07.17 (71) Applicant Hebei Yiling Pharmaceutical Research Institute Co., Ltd. Address 050035 No. 238, Tianshan Street, High-tech Development Zone, Shijiazhuang City, Hebei Province (72) Inventors: Jia Zhenhua, Hou Yunlong, Li Mengnan, Guo Zhifang, Tong Yanan, Li Faguang, Wang Xiaohang (74) Patent Agency: Beijing Sanyou Intellectual Property Agency Co., Ltd. 11127 Patent Attorneys: Zhang Debin, Han Lei (51) Int.Cl. C07D 401 / 06 (2006.01) A61K 31 / 454 (2006.01) A61P 27 / 00 (2006.01) (54) Invention Name: Piperidindole Derivatives and Their Preparation Methods and Applications (57) Abstract: This invention provides a piperidinindole derivative, its preparation method and applications. Specifically, this invention provides compounds having structural formulas A and I or their pharmaceutically acceptable forms, which can be used to prepare drugs for treating diseases or disorders mediated by complement bypass pathway dysregulation, particularly drugs for treating diseases or disorders mediated by complement factor B. CN 122161820 A 2026.06.05 CN 1 22 16 18 20 A