Novel nucleic acid molecules

Abstract

To provide improved therapeutic approaches for the treatment of diseases.SOLUTION: The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising the nucleic acid molecules. The nucleic acid molecules, (pharmaceutical) compositions or vaccines and kits are useful for treating a variety of diseases such as cancer, infectious diseases, autoimmune diseases, allergies or graft-versus host disease.SELECTED DRAWING: None

Description

[Background technology]

[0001] Unlike traditional protein-based vaccines, nucleic acid vaccines are based on nucleic acid molecules (DNA or RNA) that encode vaccine antigens. DNA vaccines typically consist of antigen-encoding genes inserted into bacterial plasmids under the control of eukaryotic promoters, while RNA vaccines typically use messenger RNA (mRNA) or other antigen-encoding RNA molecules. Like protein vaccines, nucleic acid vaccines can be delivered via a variety of different routes, including intramuscular, subcutaneous, mucosal, or transdermal delivery. However, unlike protein antigens, effective nucleic acid vaccines must enter the cytoplasm of cells at the injection site to induce antigen expression in vivo, allowing antigen presentation on major histocompatibility molecules (MHC) and T cell recognition (Non-Patent Document 1 and Non-Patent Document 2).

[0002] DNA vaccines are administered to a host and internalized by the host cells, where the antigen-encoding DNA plasmid is transcribed in the nucleus and translated in the cytoplasm by the host's cellular machinery. Unlike DNA vaccines, antigen-encoding mRNA only needs to enter the cytoplasm, where translation occurs to transfect the cell. In either case, the resulting protein is processed into peptides and ultimately presented on the surface of host cells in the context of major histocompatibility complex (MHC) molecules. The peptide-MHC complexes are recognized by antigen-specific T cells, resulting in a cellular host immune response (Non-Patent Document 2).

[0003] There are two types of MHC receptor presentation. MHC class I molecules (abundantly expressed on all nucleated cells and platelets) bind to endogenously produced peptides, such as viral peptides and tumor antigens, in the endoplasmic reticulum (ER). Specifically, MHC class I molecules present peptides resulting from proteolytic cleavage of endogenous proteins. The cleaved peptide fragments bind to the transporter of antigenic peptides (TAP) in the endoplasmic reticulum (ER), where they undergo further trimming of the N-terminal residues and bind to the MHC class I complex (Non-Patent Document 3).

[0004] In contrast, MHC class II molecules are primarily expressed by professional antigen-presenting cells (APCs), such as macrophages, B cells, and especially dendritic cells (DCs). MHC class II molecules obtain peptides from endocytosed antigens in endocytic vesicles. Specifically, class II molecules primarily present peptides from exogenous or plasma membrane proteins that are taken up by APCs during endocytosis. Antigens are processed through a series of endosomal compartments, which are equipped with a denaturing environment and a series of proteolytic and denaturing enzymes (Non-Patent Document 4). Because the majority of MHC class II epitopes are generated by peptide cleavage and processing by endosomal and lysosomal proteases, MHC class II epitopes are primarily derived from endocytosed proteins and antigens that reside in or pass through the endocytic pathway. Proteins that do not directly access the endocytic pathway (e.g., antigens naturally present in the cytoplasm, non-endocytic organelles, or nucleus) are generally poorly presented in the MHC class II context.

[0005] The antigen / MHC complex is recognized by T lymphocytes bearing antigen-specific TCRs (T cell receptors). Antigenic peptides presented in an MHC class I context are then recognized by CD8 + The complex of antigenic peptide and MHC class II molecule is recognized by cytotoxic T lymphocytes (CTLs), but not by CD4 + -Recognized by T helper cells. CD8 + CTLs mediate important cell-mediated effector functions, including cytotoxicity against cancerous or virus-infected cells, but CD4 +T helper cells play a key role in regulating CTL effector function and antibody production. Nucleic acid vaccines offer many advantages over traditional peptide / protein vaccines, including simplified vaccine design, which reduces costs and production time. Furthermore, nucleic acid vaccines can easily deliver multiple antigens in a single immunization and induce both humoral and cellular immune responses, reducing the likelihood of tumor / pathogen escape. Furthermore, unlike peptide-based vaccines, nucleic acid-based vaccines are not restricted by the patient's HLA type. Furthermore, in vivo antigen expression and endogenous post-translational modifications result in native protein structures that ensure proper processing and immune presentation. From a safety perspective, there is no need to purify proteins from pathogens, and cloning or synthesizing nucleic acids avoids the need for the use of pathogenic microorganisms in vaccine production, making nucleic acid vaccines generally safe and tolerable (Non-Patent Documents 1 and 2).

[0006] Despite their promising properties, DNA vaccines have been found to induce lower immune responses than other types of vaccines, including peptide, cellular, viral vector, and RNA vaccines. The relatively low immunogenicity of DNA vaccines, coupled with concerns about their potential for tumorigenesis via integration into the host genome, makes RNA-based vaccines particularly attractive. However, antigens encoded by RNA vaccines are typically translated in the cytoplasm and degraded by the proteasome, primarily targeting CD8+ cells. + This results in MHC class I-mediated presentation to T cells. To enhance CTL-mediated immune responses or induce antibody production, additional stimulation of productive T helper cell responses via the MHC class II pathway is highly desirable (Non-Patent Document 2).

[0007] Various strategies have been tested in preclinical models to explore the therapeutic potential of nucleic acid vaccines, including novel plasmid vectors and codon optimization to enhance antigen expression, new gene transfection systems or electroporation to increase delivery efficiency, protein or live viral vector boosting regimens to maximize immunostimulation, and the composition of nucleic acid vaccines with conventional or molecular adjuvants (Non-Patent Document 1). Several studies have shown that adding a lysosomal targeting signal to the antigen-coding sequence can result in productive T helper cell responses. Furthermore, tumor antigen mRNA fused to a signal peptide and HLA class II sorting can result in HLA class I and II presentation (Patent Document 1, Non-Patent Document 5, and Non-Patent Document 6). Diebold et al. (Non-Patent Document 7) demonstrated that dendritic cells expressing cDNA as transferrin receptor (TfR) or invariant chain fusions can generate MHC class II-specific immune responses in addition to MHC class I responses. Kreiter et al. (Non-Patent Document 6) reported that combining an N-terminal leader peptide with an MHC class I transport signal (MITD) attached to the C-terminus of an RNA-encoded antigen significantly improved the presentation of MHC class I and class II epitopes in human and mouse dendritic cells (DCs).

[0008] Nucleic acid vaccine technology has made great strides in the 20 years since its initial discovery. + and CD4 + There remains a lack of effective strategies to enhance both T cell responses and thereby improve the therapeutic or prophylactic efficacy of nucleic acid-based vaccines. Boyle et al. (Non-Patent Document 8), Deliyannis et al. (Non-Patent Document 9), and Xu et al. (Non-Patent Document 10) all describe DNA vaccines encoding fusion proteins with the extracellular domain of CTLA4. These extracellular domains specifically target the fusion antigen Ka1. [Prior art documents] [Patent documents]

[0009] [Patent Document 1] International Publication No. 2002 / 12281

Non-Patent Literature

[0010]

Non-Patent Literature 1

Non-Patent Literature 2

Non-Patent Literature 3

Non-Patent Literature 4

Non-Patent Literature 5

Non-Patent Literature 6

Non-Patent Literature 7

Non-Patent Literature 8

Non-Patent Literature 9

Non-Patent Literature 10

Summary of the Invention

Problems to be Solved by the Invention

[0011] The object of the present invention is to fulfill the need in the art and to provide improved therapeutic approaches for the treatment of the diseases identified herein. The object underlying the present invention is solved by the claimed subject matter, in particular by providing nucleic acids encoding fusion proteins with functional transmembrane domains for improved antigen "loading" of MHC-I and MHC-II in the respective cellular compartments. DETAILED DESCRIPTION OF THE INVENTION

[0012] Although the present invention is described in detail below, it should be understood that the invention is not limited to the particular methodology, protocols, and reagents described herein, as these may vary. It should also be understood that the terms used herein are not intended to limit the scope of the invention, which is limited only by the appended claims. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0013] The following describes the components of the present invention. While these components are listed with specific embodiments, it should be understood that they can be combined in any number and in any manner to create further embodiments. The various described examples and preferred embodiments should not be construed as limiting the invention to only the explicitly described embodiments. This description should be understood to support and encompass embodiments combining the explicitly described embodiments with any number of the disclosed and / or preferred components. Furthermore, unless the context indicates otherwise, any order and combination of all components described herein should be considered disclosed by the description of this application.

[0014] Unless the context otherwise requires, throughout the following specification and claims, the term "comprise" and variations such as "comprises" and "comprising" will be understood to mean the inclusion of the specified elements, integers, or steps, but not the exclusion of any other unspecified elements, integers, or steps. The term "consisting of" is a specific embodiment of the term "comprises," in which any other unspecified elements, integers, or steps are excluded. In the context of the present invention, the term "comprising" encompasses the term "consisting of." Thus, the term "comprising" encompasses "including" and "consisting of," e.g., a composition "comprising" X may consist solely of X or may include additional elements (e.g., X+Y).

[0015] The terms "a," "an," and "the," and similar references used in describing the present invention (particularly in the claims) should be construed to cover both the singular and the plural unless otherwise stated herein or otherwise clearly contradicted by context. The recitation of ranges of values ​​herein is merely intended to serve as a shorthand method of referring individually to each separate value within the range. Unless otherwise stated herein, each separate value is incorporated into the specification as if it were individually recited herein. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.

[0016] The term "substantially" does not exclude "completely", for example, a composition that is "substantially free" of Y may be completely free of Y. Where necessary, the term "substantially" may be omitted from the definition of the present invention.

[0017] The term "about" in reference to a number x means x±10%.

[0018] In the present invention, different features of alternatives and embodiments may be combined with each other unless otherwise specified.

[0019] For clarity and readability, the following definitions are provided. Any technical features mentioned in these definitions can be read in each and every embodiment of the present invention. Further definitions and explanations may be specifically provided in connection with these embodiments.

[0020] definition artificial nucleic acid molecule An artificial nucleic acid molecule may typically be understood as a nucleic acid molecule (e.g., DNA or RNA) that does not occur in nature. In other words, an artificial nucleic acid molecule may be understood as a non-natural nucleic acid molecule. Such a nucleic acid molecule may be non-natural due to its individual sequence (not occurring in nature) and / or other modifications (e.g., structural modifications of nucleotides that do not occur in nature). An artificial nucleic acid molecule may be a DNA molecule, an RNA molecule, or a hybrid molecule comprising a DNA portion and an RNA portion. Typically, an artificial nucleic acid molecule can be designed and / or produced by genetic modification methods to correspond to a desired artificial nucleotide sequence (heterologous sequence). In this context, an artificial sequence is usually a sequence that cannot occur in nature, i.e., differs from the wild-type sequence by at least one nucleotide. The term "wild-type" may be understood as a sequence that occurs in nature. Furthermore, the meaning of the term "artificial nucleic acid molecule" is not limited to "one single molecule" but is typically understood to include a collection of identical molecules. Thus, an artificial nucleic acid molecule may also refer to a plurality of identical molecules contained in an aliquot.

[0021] DNADNA is a common abbreviation for deoxyribonucleic acid. DNA is a nucleic acid molecule, i.e., a polymer composed of nucleotides. These nucleotides are typically monomers of deoxyadenosine monophosphate, deoxythymidine monophosphate, deoxyguanosine monophosphate, and deoxycytidine monophosphate, which are composed solely of a sugar moiety (deoxyribose), a base moiety, and a phosphate moiety and polymerize with a characteristic backbone structure. The backbone structure is typically formed by a phosphodiester bond between the sugar moiety (i.e., deoxyribose) of a first nucleotide and the phosphate moiety of an adjacent second monomer. The specific order of the monomers, i.e., the order of the bases attached to the sugar / phosphate backbone, is called the DNA sequence. DNA can be single-stranded or double-stranded. In the double-stranded form, nucleotides of the first strand typically hybridize with nucleotides of the second strand, for example, by A / T base pairing and G / C base pairing.

[0022] Heterologous sequences Two sequences are typically understood to be "heterologous" if they are not derived from the same gene, i.e., heterologous sequences do not naturally occur in the same nucleic acid molecule (e.g., the same mRNA) even though they may originate from the same organism.

[0023] Cloning Site A cloning site is typically understood to be a segment of a nucleic acid molecule suitable for the insertion of a nucleic acid sequence, for example, a nucleic acid sequence comprising an open reading frame. The insertion may be performed by any molecular biological method known to those skilled in the art, for example, by restriction enzyme treatment and ligation. A cloning site typically contains one or more restriction enzyme recognition sites (restriction enzyme sites). These one or more restriction enzyme sites can be recognized by a restriction enzyme that cuts DNA at these sites. A cloning site containing more than one restriction enzyme site is sometimes called a multiple cloning site (MCS) or polylinker.

[0024] nucleic acid moleculeA nucleic acid molecule is a molecule comprising, preferably consisting of, a nucleic acid component. The term nucleic acid molecule preferably refers to a DNA or RNA molecule. It is preferably used synonymously with the term "polynucleotide." A nucleic acid molecule is preferably a polymer comprising or consisting of nucleotide monomers covalently linked to each other by sugar / phosphate backbone phosphodiester bonds. The term "nucleic acid molecule" also includes modified nucleic acid molecules, such as, for example, base-modified, sugar-modified, or backbone-modified DNA or RNA molecules.

[0025] Open reading frame An open reading frame (ORF) in the present invention may typically be a sequence of several nucleotide triplets that can be translated into a peptide or protein. An open reading frame preferably comprises an initiation codon at its 5' end, i.e., a combination of three consecutive nucleotides (ATG) that usually encodes the amino acid methionine, followed by a region having a length that is usually a multiple of three nucleotides. An ORF preferably terminates with a stop codon (e.g., TAA, TAG, TGA). Typically, this is the only stop codon in an open reading frame. Thus, an open reading frame in the present invention is preferably a nucleotide sequence consisting of a number of nucleotides divisible by three, which begins with an initiation codon (e.g., ATG) and preferably terminates with a stop codon (e.g., TAA, TGA, or TAG). An open reading frame can be isolated or incorporated into a longer nucleic acid sequence, for example, in a vector or mRNA. An open reading frame may also be referred to as a "(protein) coding sequence," or preferably, a "coding sequence."

[0026] peptideA peptide or polypeptide is typically a polymer of amino acid monomers linked by peptide bonds. It typically contains fewer than 50 monomer units. However, the term peptide does not exclude molecules with more than 50 monomer units. Longer peptides, typically containing 50-600 monomer units, are also called polypeptides.

[0027] Multivalent / Multivalent Compositions The terms "polyvalent composition" or "multivalent composition" are recognized and understood by those skilled in the art and are intended to refer to, for example, a composition or vaccine comprising different antigens or epitopes of different antigens, or different epitopes of the same antigen, or any combination thereof. These terms describe that the vaccine or composition has more than one valence. In the context of the present invention, a multivalent cancer vaccine comprises at least one artificial nucleic acid molecule, for example, RNA encoding antigenic peptides or proteins derived from several different antigens, or RNA encoding different epitopes derived from the same antigen, or a combination thereof.

[0028] protein A protein typically comprises one or more peptides or proteins. Proteins are typically folded into a three-dimensional form, which may be necessary for the protein to perform its biological function.

[0029] Restriction enzyme site A restriction enzyme site, also called a "restriction enzyme recognition site," is a nucleotide sequence recognized by a restriction enzyme. A restriction enzyme site is typically a short, preferably palindromic, nucleotide sequence, e.g., a sequence comprising 4 to 8 nucleotides. A restriction enzyme site is preferably specifically recognized by a restriction enzyme. A restriction enzyme typically cleaves a nucleotide sequence containing the restriction enzyme site at this site. In a double-stranded nucleotide sequence, such as a double-stranded DNA sequence, a restriction enzyme typically cleaves both strands of the nucleotide sequence.

[0030] RNA, mRNA RNA is a common abbreviation for ribonucleic acid. RNA is a nucleic acid molecule, i.e., a polymer composed of nucleotides. These nucleotides are usually monomers of adenosine monophosphate, uridine monophosphate, guanosine monophosphate, and cytidine monophosphate, linked together along a so-called backbone. The backbone is formed by a phosphodiester bond between the sugar (i.e., ribose) of the first monomer and the phosphate moiety of the second adjacent monomer. A specific sequence of monomers is called an RNA sequence. RNA can usually be obtained, for example, by transcription of a DNA sequence inside a cell. In eukaryotic cells, transcription usually occurs inside the nucleus or mitochondria. In vivo, transcription of DNA usually results in so-called premature RNA, which must be processed into so-called messenger RNA (usually abbreviated as mRNA). For example, processing of premature RNA in eukaryotes involves various different post-transcriptional modifications, such as splicing, 5'-capping, polyadenylation, and export from the nucleus or mitochondria. This entire process is also called RNA maturation. Mature messenger RNA usually provides a nucleotide sequence that can be translated into the amino acid sequence of a specific peptide or protein. Typically, a mature mRNA contains a 5'-cap, a 5'-UTR, an open reading frame, a 3'-UTR, and a poly(A) sequence. RNA (preferably mRNA) of the present invention can be prepared using any method known in the art, such as solid-phase RNA synthesis, as well as in vitro methods (e.g., RNA in vitro transcription reactions, etc.).

[0031] RNA in vitro transcription / in vivo transcriptionThe terms "RNA in vitro transcription" or "in vivo transcription" refer to the process by which RNA is synthesized in a cell-free system (in vitro). DNA, particularly plasmid DNA (or PCR product), is usually used as a template for generating RNA transcripts. RNA can be obtained by DNA-dependent in vitro transcription of a suitable DNA template, which according to the present invention is preferably a linearized plasmid DNA template. The promoter for controlling in vitro transcription can be any promoter of any DNA-dependent RNA polymerase. Specific examples of DNA-dependent RNA polymerases are T7, T3, and SP6 RNA polymerases. DNA templates for in vitro RNA transcription can be obtained by cloning nucleic acids, particularly cDNAs corresponding to the respective RNA to be in vitro transcribed, and introducing them into a vector suitable for in vitro transcription, such as plasmid DNA. In a preferred embodiment of the present invention, the DNA template is linearized with an appropriate restriction enzyme before being transcribed in vitro. cDNA can be obtained by reverse transcription of mRNA or chemical synthesis. Furthermore, DNA templates for in vitro RNA synthesis can also be obtained by gene synthesis.

[0032] Reagents used for RNA in vitro transcription typically include: a DNA template (linear plasmid DNA or PCR product) with a promoter sequence that has high binding affinity for the respective RNA polymerase, such as a bacteriophage-encoded RNA polymerase (T7, T3, SP6, or Syn5); ribonucleotide triphosphates (NTPs) for the four bases (adenine, cytosine, guanine, and uracil); optionally, a cap analog as defined herein (e.g., m7G(5')ppp(5')G(m7G)); optionally, further modified nucleotides as defined herein; a promoter within the DNA template. a DNA-dependent RNA polymerase (e.g., T7, T3, SP6, or Syn5 RNA polymerase) capable of binding to the sequence; optionally, a ribonuclease (RNase) inhibitor to inactivate potentially contaminating RNases; optionally, a pyrophosphatase to degrade pyrophosphates that may inhibit RNA in vitro transcription; MgCl2 to provide Mg2+ ions as a cofactor for the polymerase; a buffer (TRIS or HEPES) to maintain a suitable pH value, which may also contain an antioxidant (e.g., DTT), and / or an optimal concentration of a polyamine such as spermidine, or a buffer system as disclosed in WO 2017 / 109161. In the context of nucleic acid vaccine production, it may be necessary to provide GMP-grade RNA. GMP-grade RNA can be suitably produced using a manufacturing process approved by regulatory authorities. Therefore, in a particularly preferred embodiment, RNA production is carried out under current Good Manufacturing Practice (GMP) in accordance with WO 2016 / 180430, and various quality control steps are carried out at the DNA and RNA levels. Therefore, the RNA of the present invention is GMP-grade RNA, particularly GMP-grade RNA mRNA.

[0033] The resulting RNA product is preferably purified using PureMessenger® (CureVac, Tubingen, Germany; RP-HPLC according to WO 2008 / 077592) and / or tangential flow filtration (described in WO 2016 / 193206). When nucleic acid sequences are described in the context of the present invention, these sequences generally include both the specific RNA or DNA sequence and its respective corresponding DNA or RNA counterpart. For example, when a DNA sequence is provided, those skilled in the art will understand that the corresponding RNA sequence can be obtained by exchanging thymine for uracil residues, and vice versa.

[0034] Nucleic acid molecule sequence The sequence of a nucleic acid molecule is typically understood to be the specific and particular order, i.e., succession, of its nucleotides. The sequence of a protein or peptide is typically understood to be the order, i.e., succession, of its amino acids.

[0035] Sequence identityTwo or more sequences are identical if they have the same length and order of nucleotides or amino acids. The percentage of identity typically describes the degree to which two sequences are identical. That is, it typically describes the percentage of nucleotides that match the identical nucleotides in a reference sequence at that sequence position. When determining the degree of identity (% identity), the compared sequences are usually considered to have the same length, i.e., the length of the longest sequence among the sequences being compared. This means that a first sequence consisting of 8 nucleotides is 80% identical to a second sequence consisting of 10 nucleotides that includes the first sequence. In other words, in the present invention, sequence identity preferably relates to the percentage of nucleotides or amino acids that have identical positions in two or more sequences of the same length. Specifically, the "% identity" of two amino acid sequences or two nucleic acid sequences can be determined by aligning the sequences for optimal comparison purposes (e.g., gaps can be introduced into one sequence for optimal alignment with the other sequence) and comparing the amino acids or nucleotides at corresponding positions. Gaps are usually considered to be non-identical positions, regardless of their actual position in the alignment. "Optimal alignment" is usually the alignment of two sequences that results in the highest percent identity. The percent identity is determined by the number of identical nucleotides in the sequences being compared (i.e., % identity = # of identical positions / total # of positions x 100). The determination of percent identity between two sequences can be accomplished using mathematical algorithms known to those skilled in the art.

[0036] stabilized nucleic acid moleculesA stabilized nucleic acid molecule is a nucleic acid molecule, preferably a DNA or RNA molecule, that has been modified to be more stable than an unmodified nucleic acid molecule against degradation or degradation, for example, by environmental factors or enzymatic degradation, such as degradation by exonucleases or endonucleases. Preferably, the stabilized nucleic acid molecule of the present invention is stabilized in a cell (e.g., a prokaryotic or eukaryotic cell), preferably a mammalian cell (e.g., a human cell). The stabilizing effect can also be exerted outside the cell, for example, in a buffer solution, for example, during the production process of a pharmaceutical composition containing the stabilized nucleic acid molecule.

[0037] Transfection The term "transfection" refers to the introduction of a nucleic acid molecule, such as a DNA or RNA (e.g., mRNA) molecule, into a cell, preferably a eukaryotic cell. In the present invention, the term "transfection" includes any method known to those skilled in the art for introducing a nucleic acid molecule into a cell, preferably a eukaryotic cell, such as a mammalian cell. Such methods include, for example, electroporation, lipofection (e.g., based on cationic lipids and / or liposomes), calcium phosphate precipitation, nanoparticle-based transfection, virus-based transfection, or cationic polymer (e.g., DEAE-dextran or polyethyleneimine)-based transfection. Preferably, the introduction is non-viral.

[0038] vectorThe term "vector" refers to a nucleic acid molecule, preferably an artificial nucleic acid molecule. A vector in the present invention is suitable for incorporating or carrying a desired nucleic acid sequence, such as a nucleic acid sequence containing an open reading frame. Such a vector may be a storage vector, an expression vector, a cloning vector, a transfer vector, or the like. A storage vector is a vector that can conveniently store a nucleic acid molecule, such as an mRNA molecule. Thus, the vector may contain, for example, a sequence corresponding to a desired mRNA sequence or a portion thereof (e.g., a sequence corresponding to the 3'-UTR and coding sequence of an mRNA). An expression vector can be used to produce an expression product such as RNA (e.g., mRNA), or a peptide, polypeptide, or protein. For example, an expression vector may contain sequences necessary for transcription of a contiguous sequence of the vector, such as a promoter sequence (e.g., an RNA polymerase promoter sequence). A cloning vector is typically a vector that contains a cloning site that can be used to incorporate a nucleic acid sequence into the vector. A cloning vector may be, for example, a plasmid vector or a bacteriophage vector. A transfer vector may be a vector suitable for transferring a nucleic acid molecule into a cell or organism, such as a viral vector. A vector in the present invention may be, for example, an RNA vector or a DNA vector. Preferably, the vector is a DNA molecule. Preferably, a vector in the sense of the present application comprises a cloning site, a selection marker (e.g., an antibiotic resistance factor), and a sequence suitable for propagation of the vector (e.g., an origin of replication).

[0039] Vehicle A vehicle is typically understood to be a material suitable for storing, transporting, and / or administering a compound (e.g., a pharmaceutically active compound). For example, it may be a physiologically acceptable liquid suitable for storing, transporting, and / or administering a pharmaceutically active compound.

[0040] This application is submitted with an electronic format Sequence Listing (WIPO Standard ST.25), which is part of the description of this application. The information contained in the electronic format of the Sequence Listing submitted with this application is incorporated herein by reference in its entirety. Reference herein to a "SEQ ID NO:" refers to the corresponding nucleic acid sequence or amino acid (aa) sequence in the Sequence Listing with the respective identifier. For many sequences, the Sequence Listing also provides additional details, such as information about specific structural features, sequence optimization, GenBank identifiers, or their coding capabilities. In particular, such information may be included in the WIPO Standard ST.25 Sequence Listing numerical identifiers. <223> Therefore, the numerical identifier <223> The information provided thereunder is expressly incorporated herein in its entirety and should be understood as an integral part of the description of the underlying invention.

[0041] The present invention is based, in part, on the surprising discovery that fusion of antigens to appropriate "targeting" sequences derived from a group of signaling proteins involved in the immune response favorably routes these antigens to MHC class I and MHC class II processing compartments. These "targeting" sequences preferably comprise or consist of transmembrane domains. Proteins containing the "targeting" sequences used (e.g., CTLA4) are "fast-recycling" proteins that are expressed on the outer surface of the plasma membrane and are typically readily and repeatedly internalized to enter the endosomal pathway, which preferably intersects with the MHC class I pathway, and particularly the MHC class II pathway. Thus, the "targeting" approach of the present invention differs from other prior art approaches in that it is preferable to target antigens to a desired intracellular pathway rather than a specific cell type. For efficient delivery of antigenic sequences to MHC class I and MHC class II processing compartments, nucleic acid molecules can be engineered to encode antigens / epitopes fused to appropriate amino acid sequences derived from fast-recycling proteins present in the plasma membrane. Targeting can be achieved by using the full-length amino acid sequence of the protein, or preferably its transmembrane (and optionally cytoplasmic) domain, preferably with an appropriate signal peptide. Fusing these sequences to the antigenic peptide or protein of interest preferably promotes localization of the antigen / epitope to the plasma membrane and recycling to cellular compartments such as the endoplasmic reticulum, endosomes, or lysosomes, where MHC class I and II processing and loading occur. The unprecedented targeting strategy presented herein utilizes immune response activation signaling (IRST) proteins present in the plasma membrane of immune cells. epm ) protein group, exploiting the fast recycling properties conferred by amino acid sequences (especially transmembrane domains) derived from the protein group. This effectively routes antigenic peptides or proteins to the plasma membrane, anchoring them therein, and subsequently fusion with IRST. epm By recycling the encoded antigen / epitope via its derived protein domain to a cellular compartment that intersects with the MHC processing and loading pathway, presentation of the encoded antigen / epitope by MHC class I and MHC class II in recipient cells, and thus induction of an antigen-specific immune response against immunogenic epitopes or whole antigens by nucleic acid-based vaccines, is preferably increased. Thus, the targeting approach presented herein utilizes membrane-bound IRSTs rather than using state-of-the-art approaches that directly target translated antigenic proteins or peptides to endosomal / lysosomal compartments via fusion of different trafficking sequences. epm Utilizing common pathways for fast protein recycling.

[0042] To this end, we generated nucleic acid molecules encoding such antigenic fusion proteins and investigated their therapeutic potential in tumor models. Therefore, antigenic proteins, peptides, or epitopes of interest were linked to selected domains or full-length proteins derived from several fast-recycling immune response-activating signaling proteins. Typically, nucleic acid constructs were designed by removing the extracellular domain of the protein and replacing it with the antigen / epitope. The inclusion of a signal peptide and a transmembrane domain optimizes transport and anchoring to external sites in the plasma membrane. Furthermore, appropriate linkers were introduced to enable correct presentation of the immunogenic peptide by MHC class I and class II molecules. Helper T cell epitopes may also be included to enhance the induction of antigen-specific immune responses against the encoded epitope. This design strategy enabled targeting of specific epitopes or entire antigens to MHC class I and class II-enriched cellular compartments.

[0043] Surprisingly, antigenic fusion proteins have been shown to effectively induce antigen-specific T cell responses and effectively reduce tumor growth in mouse models. The novel targeting approach presented herein provides a convenient and effective means to preferably ensure antigen entry into the MHC processing pathway. This targeting strategy preferably improves the induction of antigen-specific immune responses against antigenic peptides, proteins, or epitopes, opening up new possibilities for improving the therapeutic efficacy of nucleic acid vaccines.

[0044] In a first aspect, the present invention relates to an artificial nucleic acid molecule comprising at least one coding region, said at least one coding region encoding: a. at least one antigenic peptide or protein, and b. at least one further amino acid sequence derived from at least one immune response signaling protein located in the outer plasma membrane, as defined below. Preferably, said at least one further amino acid sequence comprises or consists of at least one transmembrane domain of said protein. Without wishing to be bound by a particular theory, it is believed that at least one immune response signaling protein located in the outer plasma membrane (herein referred to as "IRST") epm At least one additional amino acid sequence derived from the IgG1A-specific ... + and CD4 + It is postulated to result in co-stimulation and expansion of T cell subsets.

[0045] Therefore, the artificial nucleic acid molecule of the present invention (which can preferably be RNA as described below) contains at least one IRST epm The artificial nucleic acid molecule (preferably RNA) of the present invention encodes an amino acid sequence derived from an IRST (preferably selected based on its ability to route the fused amino acid sequence to a desired compartment of MHC processing and loading), and at least one antigenic peptide or protein (preferably selected based on the particular disease or condition to be treated or prevented). Both are typically expressed as a fusion protein, also referred to herein as an "antigen fusion protein." As described below, the artificial nucleic acid molecule (preferably RNA) of the present invention can be expressed by combining several (identical or different) IRSTs. epmAn artificial nucleic acid molecule (preferably RNA) of the invention can encode an antigenic polypeptide construct comprising an amino acid sequence derived from the polypeptide, several (identical or different) antigenic peptides or proteins, and optionally further (poly-)peptides, proteins, or protein domains (e.g., signal peptides, peptide linkers, and T-helper epitopes) in any combination disclosed herein. However, the artificial nucleic acid molecule (preferably RNA) of the invention can encode an antigenic polypeptide construct comprising at least one antigenic peptide or protein and at least one IRST. epm It is believed that the polypeptide encodes an "antigenic polypeptide construct" that contains additional amino acid sequences derived therefrom.

[0046] Code Region IRST epm Derived amino acid sequence Surprisingly, the inventors have discovered that antigenic peptides or proteins bind to the immune response activation signaling protein ("IRST"), which is located on the outer plasma membrane. epm ") effectively mediate MHC presentation and preferably result in an increased T cell response. Without wishing to be bound by theory, IRST epm The derived amino acid sequence may preferably contain a targeting sequence that mediates translocation to a defined intracellular compartment for MHC processing and loading, resulting in enhanced MHC class I and class II presentation of antigenic peptides and proteins fused thereto. The term "immune response activation signal transduction" refers to a cascade of processes in which a signal interacts with a receptor, causes changes in the level or activity of second messengers or other downstream targets, and ultimately leads to the activation or perpetuation of an immune response. Hence, the term "IRST epm By "proteins" is meant proteins located in the outer plasma membrane, i.e., the leaflet of the plasma membrane facing away from the cytoplasm, which are involved in such signaling cascades. Thus, IRST epm The protein is preferably expressed on the plasma membrane of an immune cell, more preferably an antigen-presenting cell (APC). Due to the complexity of the intracellular signaling pathway, the term IRSTepm It is recognized that proteins can include proteins with dual roles in regulating the immune response and can have inhibitory and activating effects in different settings. epm The proteins are shown in Table 1 below. Preferably, the protein is "IRST epm The protein is rapidly recycled at the cell surface.

[0047] As explained above, the artificial nucleic acid molecule of the present invention comprises at least one IRST as defined herein. epm A protein includes at least one amino acid sequence "derived from" a protein. As used herein, the term "derived" generally indicates that a sequence is isolated from, related to, based on, or homologous to a reference sequence. Thus, a sequence "derived from" a reference sequence includes a sequence identical to the reference sequence (i.e., a full-length sequence exhibiting 100% sequence identity with the reference sequence), as well as variants, fragments, and derivatives of the reference sequence. This definition can apply, mutatis mutandis, to both amino acid and nucleic acid sequences.

[0048] The artificial nucleic acid molecules (preferably RNA) of the present invention preferably contain, in at least one coding region, an IRST as described herein. epm The polypeptide encodes at least one amino acid sequence derived from the polypeptide or a fragment, variant, or derivative of any of said proteins.

[0049] The term "(protein / amino acid sequence) variant" as used herein generally refers to a "sequence variant", i.e. a protein or (poly)peptide comprising an amino acid sequence that differs by at least one amino acid residue from the reference (or "parent") amino acid sequence of a reference (or "parent") protein or (poly)peptide.

[0050] Thus, a "variant" protein / (poly)peptide may preferably contain at least one amino acid mutation, substitution, insertion, or deletion in its amino acid sequence compared to the respective reference sequence. The substitution can be selected from conservative or non-conservative substitutions. A protein / (poly)peptide "variant" may contain at least one conservative amino acid substitution, in which amino acids from the same class are exchanged for one another. In particular, these are amino acids with aliphatic side chains, positively or negatively charged side chains, aromatic groups in the side chains, or amino acids whose side chains are capable of forming, for example, hydrogen bridges (e.g., side chains with hydroxyl functions). Conservative constructions allow, for example, an amino acid with a polar side chain to be substituted with another amino acid with a corresponding polar side chain, or, for example, an amino acid characterized by a hydrophobic side chain to be substituted with another amino acid with a corresponding hydrophobic side chain (e.g., threonine (serine) for serine (threonine) or isoleucine (leucine) for leucine (isoleucine)). However, non-conservative amino acid substitutions are also contemplated herein.

[0051] Preferably, the term "variant" as used herein includes naturally occurring variants, such as preproproteins, proproteins, and proteins / (poly)peptides that have undergone post-translational proteolytic processing (which may include removal of the N-terminal methionine, the signal peptide, and / or conversion of an inactive or non-functional protein into an active or functional one), and naturally occurring mutant proteins / (poly)peptides. The term "variant" further encompasses engineered variants of proteins / (poly)peptides that can be (sequence-) modified to introduce or eliminate specific biological properties and / or functionality. The term "transcript variant" or "splice variant" in the context of a protein / (poly)peptide refers to a variant generated from messenger RNA that is initially transcribed from the same gene and subsequently undergoes alternative (or differential) splicing, whereby specific exons of the gene may be included or excluded from the final processed messenger RNA (mRNA). It should be noted that the term "variant" may be essentially defined by a minimum degree of sequence identity (and preferably a desired biological function / property) compared to a reference protein / (poly)peptide. Thus, fragments or specific derivatives (which also differ in amino acid sequence from the reference protein / (poly)peptide) can also be classified as "variants". A "variant" as defined herein can therefore be derived from, isolated from, related to or based on a reference protein / (poly)peptide or a fragment or derivative thereof.

[0052] The term "(protein / amino acid sequence) variant" as used herein preferably refers to a (poly)peptide having at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to the amino acid sequence of the respective naturally occurring (wild-type) protein / (poly)peptide or fragment or derivative thereof.

[0053] The term "(protein / amino acid sequence) fragment" as used herein generally refers to a protein / (poly)peptide consisting of a contiguous subsequence of the full-length amino acid sequence of a reference (or "parent") protein / (poly)peptide, which, with respect to its amino acid sequence, is truncated at the N-terminus, C-terminus, and / or within the sequence compared to the amino acid sequence of said reference protein / (poly)peptide. Such truncation can occur either at the amino acid level or at the nucleic acid level, respectively. In other words, a "fragment" can usually be a short portion of the full-length sequence of an amino acid sequence. Thus, a fragment usually consists of a sequence identical to the corresponding stretch within the full-length amino acid sequence. The term includes naturally occurring fragments (e.g., fragments resulting from naturally occurring in vivo protease activity) and engineered fragments.

[0054] The term "(protein / amino acid sequence) fragment" as used herein may mean at least 5 contiguous amino acid residues, at least 10 contiguous amino acid residues, at least 15 contiguous amino acid residues, at least 20 contiguous amino acid residues, at least 25 contiguous amino acid residues, at least 40 contiguous amino acid residues, at least 50 contiguous amino acid residues, at least 60 contiguous amino acid residues, at least 70 contiguous amino acid residues, at least 80 contiguous amino acid residues, at least 90 contiguous amino acid residues, at least 100 contiguous amino acid residues, at least 125 contiguous amino acid residues, at least 150 contiguous amino acid residues, at least 175 contiguous amino acid residues, at least 200 contiguous amino acid residues, or at least 250 contiguous amino acid residues of the amino acid sequence of a reference protein / (poly)peptide, or a variant or derivative thereof.

[0055] A preferred fragment of a sequence in the context of the present invention consists of a contiguous stretch of amino acids that corresponds to a contiguous stretch of an entity in the reference protein / (poly)peptide, which represents at least 20%, preferably at least 30%, more preferably at least 40%, more preferably at least 50%, even more preferably at least 60%, even more preferably at least 70%, and most preferably at least 80% of the entire (i.e. full-length) reference protein / (poly)peptide from which the fragment is derived, or a variant or derivative thereof.

[0056] The sequence identity indicated for such a fragment preferably refers to the entire amino acid sequence of the reference protein / (poly)peptide. Preferably, a "fragment" may typically comprise or consist of an amino acid sequence having at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to the amino acid sequence of the reference protein / (poly)peptide or a variant or derivative thereof.

[0057] As used herein, the term "(protein / amino acid sequence) derivative" is generally understood as a protein / (poly)peptide that has been modified to contain new or additional properties or functions relative to a reference (or "parent") protein / (poly)peptide. Derivatives can be modified to have desired biological functionality (e.g., by introducing or removing moieties or domains that confer, enhance, reduce, or eliminate target binding affinity or specificity or enzymatic activity), manufacturing properties (e.g., by introducing moieties that improve solubility, improve excretion, or allow for purification), or pharmacokinetic / pharmacodynamic properties for drug use (e.g., by introducing moieties that confer stability, bioavailability, improved absorption, distribution, and / or reduced clearance). Derivatives can be prepared by introducing or removing moieties or domains that confer the desired biological property or functionality. Such portions or domains can be introduced into the amino acid sequence (e.g., at the amino- and / or carboxyl-terminal residues) post-translationally or at the nucleic acid sequence level using standard genetic engineering techniques (see Sambrook J et al., 2012 (4th ed.), Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York). A "derivative" may be derived from (and therefore optionally include) a naturally occurring (wild-type) protein / (poly)peptide amino acid sequence, or a variant or fragment thereof. It is understood that "(protein / amino acid sequence) derivatives" can differ in their amino acid sequence from the reference protein / (poly)peptide from which they are derived (e.g., by the introduction or removal of (poly)peptide portions and / or protein domains) and can therefore also be "variants." However, while "(protein / amino acid sequence) variants" are primarily defined in terms of sequence identity with the reference amino acid sequence, derivatives are preferably characterized by the presence or absence of particular biological properties or functionality compared to the reference protein. Nevertheless, a "(protein / amino acid sequence) derivative" may comprise or consist of an amino acid sequence having preferably at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95%, or even 97% sequence identity to the amino acid sequence of a reference protein / (poly)peptide or variant or fragment thereof.

[0058] According to a preferred embodiment of the present invention, the artificial nucleic acid molecule (preferably RNA) of the present invention encodes in at least one of its coding regions at least one further amino acid sequence derived from any of the proteins set out in Table 1 below, or from a (preferably functional) fragment, variant or derivative of any of said proteins.

[0059] Preferably, in the context of the present invention, a "functional" fragment, variant, or derivative exhibits substantially the same or equivalent biological functionality as the respective "parent" or "reference" sequence. This definition is applicable to "functional" protein / peptide / amino acid sequence fragments, variants, or derivatives, as well as to "functional" nucleic acid sequence / polynucleotide fragments, variants, or derivatives. The desired biological function is preferably indicated in the context of the respective sequence. In general, a "functional" protein / peptide / amino acid sequence fragment, variant, or derivative may exhibit the same or equivalent binding properties, targeting properties, immune response induction properties, etc., as the "parent" or "reference" sequence. A "functional" nucleic acid sequence / polynucleotide fragment, variant, or derivative may preferably exhibit the same or equivalent ability as their "parent" or "reference" sequence to be encoded and expressed (i.e., optionally transcribed and translated) to produce a desired protein / peptide / amino acid sequence. A "functional" IRST epm Protein fragments, variants, and derivatives are preferably capable of targeting antigenic proteins or peptides (preferably fused thereto) to the MHC class I and preferably MHC class II processing compartments, and thus are "functional" IRSTs. epm The use of protein fragments, variants and derivatives is preferably directed to CD4 + Enhances T helper cell responses and therefore CD8 + Enhances CTL and / or antibody-mediated immunity. [Table 1-1] [Table 1-2] [Table 1-3]

[0060] According to a preferred embodiment, the artificial nucleic acid molecule (preferably RNA) according to the invention comprises, in at least one coding region thereof, at least one IRST. epmThe polypeptide may encode a further amino acid sequence derived therefrom, which sequence comprises or consists of an amino acid sequence according to any of SEQ ID NOs: 157 to 179, or a (preferably functional) fragment, variant or derivative of any of said sequences, said fragment, variant or derivative preferably comprising or consisting of an amino acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to any of these sequences.

[0061] Thus, the coding region of the artificial nucleic acid molecule (preferably RNA) of the present invention may preferably comprise a nucleic acid sequence according to any of SEQ ID NOs: 365 to 387, or a (preferably functional) fragment, variant, or derivative of any of said sequences, said fragment, variant, or derivative preferably comprising or consisting of an amino acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95%, or even 97% sequence identity to any of these sequences.

[0062] The term "(nucleic acid sequence / polynucleotide / gene) variant" refers to a nucleic acid sequence variant, i.e., a nucleic acid sequence or gene in which at least one nucleic acid comprises a nucleic acid sequence that differs from the reference (or "parent") nucleic acid sequence of the reference (or "parent") nucleic acid or gene. A variant nucleic acid or gene can therefore preferably comprise at least one mutation, substitution, insertion, or deletion in its nucleic acid sequence compared to the respective reference sequence. Preferably, the term "variant" as used herein includes naturally occurring variants and engineered variants of a nucleic acid sequence or gene. Thus, a "variant" as defined herein can be derived from, isolated from, related to, based on, or homologous to a reference nucleic acid sequence. A "variant" may preferably have at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95%, or even 97%, sequence identity to the respective naturally occurring (wild-type) nucleic acid sequence or gene, or the nucleic acid sequence of a homologue, fragment, or derivative thereof.

[0063] The term "(nucleic acid sequence / polynucleotide / gene) fragment" refers to a contiguous subsequence of a full-length reference (or "parent") nucleic acid sequence or gene. In other words, a "fragment" can usually be a short portion of a full-length nucleic acid sequence or gene. Thus, a fragment typically consists of a sequence identical to a corresponding stretch within a full-length nucleic acid sequence or gene. This term includes naturally occurring and engineered fragments. Preferred fragments of a sequence in the context of the present invention consist of a contiguous stretch of nucleic acid corresponding to a contiguous stretch of the entity in the nucleic acid or gene from which the fragment is derived, which represents at least 20%, at least 30%, more preferably at least 40%, more preferably at least 50%, even more preferably at least 60%, even more preferably at least 70%, and most preferably at least 80% of the entire (i.e., full-length) nucleic acid sequence or gene from which the fragment is derived. Sequence identity indicated for such fragments preferably refers to the entire nucleic acid sequence or gene. Preferably, a "fragment" may comprise a nucleic acid sequence having at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95%, or even 97% sequence identity to the reference nucleic acid sequence or gene from which it is derived.

[0064] The term "(nucleic acid sequence / polynucleotide / gene) derivative" is generally understood as a nucleic acid sequence / polynucleotide / gene that has been modified to contain new or additional properties or functions relative to a reference (or "parent") nucleic acid sequence / polynucleotide / gene. Derivatives can be modified to have desired biological functionality (e.g., resistance to enzymatic degradation, translation efficiency), manufacturing properties, or pharmacokinetic / pharmacodynamic properties for drug use (e.g., by introducing moieties that confer stability, bioavailability, improved absorption, distribution, and / or reduced clearance). Derivatives can be prepared by introducing or removing nucleic acid sequences or additional moieties that confer desired biological properties or functionality. Such nucleic acid sequences or additional moieties can be introduced using standard genetic engineering techniques (see Sambrook J et al., 2012 (4th ed.), Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York). A "derivative" may be derived from (and therefore optionally include) a naturally occurring (wild-type) nucleic acid sequence / polynucleotide / gene, or a variant or fragment thereof. It is understood that "(nucleic acid sequence / polynucleotide / gene) derivatives" can differ in nucleic acid sequence from the reference nucleic acid sequence / polynucleotide / gene from which they are derived (e.g., by the introduction or removal of a (poly)nucleotide) and can therefore also be "variants." However, although "(nucleic acid sequence / polynucleotide / gene) derivatives" are primarily defined in terms of % sequence identity with the reference nucleotide sequence, "derivatives" are preferably characterized by the presence or absence of particular biological properties or functionality compared to the reference nucleic acid sequence / polynucleotide / gene. Nevertheless, a "(nucleic acid sequence / polynucleotide / gene) derivative" may comprise or consist of an amino acid sequence having preferably at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95%, or even 97% sequence identity to the nucleic acid sequence of a reference nucleic acid sequence / polynucleotide / gene or a variant or fragment thereof.

[0065] In the context of the present invention, "(nucleic acid sequence / polynucleotide) derivatives" may include, in particular, nucleic acid sequences / polynucleotide sequences that are modified or stabilized compared to the "parent" or "reference" nucleic acid sequence from which they are derived. However, it is understood that such modified / stabilized nucleic acid sequences / polynucleotides may also be defined as "variants".

[0066] A "functional" fragment, variant or derivative of said nucleic acid sequence is preferably an IRST as defined herein. epm The nucleotide sequence encodes (and thus allows for the expression of) a further amino acid sequence derived therefrom.

[0067] According to a preferred embodiment, the coding region of the artificial nucleic acid molecule (preferably RNA) according to the present invention may preferably comprise SEQ ID NOs: 365 to 387, 573 to 595, 781 to 803, 989 to 1011, 1197 to 1219, 1613 to 1635, 1821 to 1843, 2029 to 2051, 2237 to 2259, 2445 to 2467, 2653 to 2675, 2861 to 2883, or a (preferably functional) fragment, variant, or derivative of any of said sequences, and said fragment, variant, or derivative is preferably any of these It comprises or consists of a nucleic acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to any sequence.

[0068] The artificial nucleic acid molecule (preferably RNA) according to the present invention comprises at least one or at least two multiple (identical or different) IRSTs. epm It is understood that the nucleic acid sequence may encode a derived amino acid sequence (see "Monocistronic, bi-, and multicistronic RNA").

[0069] Generally, "identical" sequences (or molecules characterized by said sequences, such as (poly)peptides or nucleic acid molecules) share 100% sequence identity, whereas "different" sequences (or molecules characterized by said sequences, such as (poly)peptides or nucleic acid molecules) share less than 100%, for example 99% or less, 90% or less, 80% or less, 70% or less, 60% or less, 50% or less, 40% or less, 30% or less, 20% or less, 10% or less, 5% or less, or 2% or less sequence identity.

[0070] Particularly preferred IRST epmThe protein may be CTLA4. The further amino acid sequence encoded by at least one coding region of the artificial nucleic acid molecule (preferably RNA) of the invention may be derived from CTLA4.

[0071] Thus, in a preferred embodiment, the artificial nucleic acid molecule (preferably RNA) of the invention may encode in at least one coding region thereof a further amino acid sequence from CTLA4 comprising or consisting of an amino acid sequence according to SEQ ID NO: 169, or a (preferably functional) fragment, variant or derivative thereof, said fragment, variant or derivative preferably comprising or consisting of an amino acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to SEQ ID NO: 169.

[0072] Preferably, an artificial nucleic acid molecule (preferably RNA) of the invention may comprise in at least one coding region thereof a nucleic acid sequence comprising or consisting of a nucleic acid sequence according to SEQ ID NO: 377, 585, 793, 1001, 1209, 1417, 1625, 1833, 2041, 2249, 2457, 2665 or 2873, or a (preferably functional) fragment, variant or derivative of any of said sequences, said fragment, variant or derivative preferably being highly preferred for any of these sequences. In any case, the nucleic acid sequence may comprise or consist of a nucleic acid sequence having, in order of increasing order, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity.

[0073] Transmembrane domain (TMD) According to a preferred embodiment, at least one IRST is encoded in at least one coding region of an artificial nucleic acid molecule (preferably RNA) according to the invention. epm Further amino acid sequences derived from IRST epm Therefore, in the artificial nucleic acid molecule (preferably RNA) of the present invention, said at least one further IRST may comprise or consist of a transmembrane domain derived from epm The derived amino acid sequence may preferably comprise or consist of b. at least one transmembrane domain.

[0074] A "transmembrane domain" is a protein domain that spans a membrane, typically a short (less than 50 amino acids) helical or beta-strand domain. Transmembrane domains can be determined experimentally, for example, by X-ray diffraction, or predicted based on sequence similarity or using known prediction tools such as MHMM, Memsat, Phobius, hydrophobic moment plot methods, etc. Without wishing to be bound by theory, "fast recycling" IRSTepm The derived transmembrane domains can advantageously anchor the fusion antigenic peptides or proteins to the plasma membrane, where they can be recycled and targeted to the cellular compartments of MHC1 and especially MHCII processing.

[0075] According to a preferred embodiment of the present invention, the artificial nucleic acid molecule (preferably RNA) of the present invention encodes, in at least one coding region thereof, at least one transmembrane domain as set out in Table 2 below, or a (preferably functional) fragment, variant or derivative of said transmembrane domain. [Table 2-1] [Table 2-2] [Table 2-3]

[0076] According to a preferred embodiment, the artificial nucleic acid molecule according to the invention comprises, in at least one coding region thereof, at least one IRST. epm The polypeptide may encode a transmembrane domain derived from a polypeptide of the present invention, which domain comprises or consists of an amino acid sequence according to any of SEQ ID NOs: 180-208, or a (preferably functional) fragment, variant, or derivative of any of said sequences, said fragment, variant, or derivative preferably comprising or consisting of an amino acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to any of these sequences.

[0077] Thus, the artificial nucleic acid molecule (preferably RNA) of the present invention may comprise, in at least one coding region thereof, a nucleic acid sequence according to SEQ ID NOs: 388 to 416, 596 to 624, 804 to 832, 1012 to 1040, 1220 to 1248, 1428 to 1456, 1636 to 1664, 1844 to 1872, 2052 to 2080, 2260 to 2288, 2468 to 2496, 2676 to 2704, 2884 to 2912, or a nucleic acid sequence comprising or consisting of a (preferably functional) fragment, variant, or derivative of any of said sequences, and said fragment, variant, or derivative may The entity preferably comprises or consists of a nucleic acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to any of these sequences.

[0078] More preferably, the artificial nucleic acid molecule (preferably RNA) of the invention may encode in at least one coding region thereof a CTLA4-derived transmembrane domain comprising or consisting of an amino acid sequence according to SEQ ID NO: 200, or a (preferably functional) fragment, variant or derivative thereof, said fragment, variant or derivative preferably comprising or consisting of an amino acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to SEQ ID NO: 200.

[0079] Preferably, an artificial nucleic acid molecule (preferably RNA) of the present invention may comprise in at least one coding region thereof a nucleic acid sequence comprising or consisting of a nucleic acid sequence according to any of SEQ ID NOs: 408, 616, 824, 1032, 1240, 1448, 1656, 1864, 2072, 2280, 2488, 2696 or 2904, or a (preferably functional) fragment, variant or derivative of any of said sequences, said fragment, variant or derivative preferably being a preferred or consisting of a nucleic acid sequence having, in increasing order of sequence identity, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97%.

[0080] Cytoplasmic domain (CD) According to a preferred embodiment, at least one IRST is encoded in at least one coding region of an artificial nucleic acid molecule (preferably RNA) according to the invention. epm The further amino acid sequence derived therefrom may optionally be (further) IRST epm Therefore, in the artificial nucleic acid molecule (preferably RNA) of the present invention, said at least one further IRST may comprise or consist of a derived cytoplasmic domain. epm The derived amino acid sequence may preferably (further) comprise or consist of: c. at least one cytoplasmic domain.

[0081] The "cytoplasmic domain" is typically the intracellular domain that interacts with the interior of the cell. Without wishing to be bound by any particular theory, IRST epm It is envisaged that the derived cytoplasmic domains confer further advantageous targeting properties to antigenic peptides or proteins encoded in the MHC1 and particularly the MHCII processing compartment.

[0082] Preferably, IRST epm The cytoplasmic domain derived from IRST epm The cytoplasmic domain and transmembrane domain may be present in addition to the transmembrane domain derived from the same or different IRSTs. epm According to some preferred embodiments, the cytoplasmic domain and the transmembrane domain may be derived from one or more contiguous IRST proteins. epm present in the derived amino acid sequence.

[0083] Transmembrane domain + cytoplasmic domain (CD) According to a preferred embodiment, at least one IRST is encoded in at least one coding region of an artificial nucleic acid molecule (preferably RNA) according to the invention. epm Further amino acid sequences derived from IRST epm Transmembrane domain and IRST derived from epm Therefore, in the artificial nucleic acid molecule (preferably RNA) of the present invention, said at least one further IRST may comprise or consist of a cytoplasmic domain derived from epm The derived amino acid sequence may preferably comprise or consist of b. at least one transmembrane domain and c. at least one cytoplasmic domain. [Table 3-1] [Table 3-2] [Table 3-3]

[0084] According to a preferred embodiment, the artificial nucleic acid molecule according to the invention comprises, in at least one coding region thereof, at least one IRST. epmThe polypeptides may encode a transmembrane domain and at least one cytoplasmic domain derived therefrom, said domains comprising or consisting of an amino acid sequence according to any of SEQ ID NOs: 76625-76647, or a (preferably functional) fragment, variant, or derivative of any of said sequences, said fragment, variant, or derivative preferably comprising or consisting of an amino acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to any of these sequences.

[0085] Thus, the artificial nucleic acid molecule (preferably RNA) of the present invention comprises, in at least one coding region thereof, a nucleic acid sequence according to SEQ ID NOs: 76648 to 76670, 76694 to 76716, 76717 to 76739, 76671 to 76693, 77004 to 770017, 76763 to 76785, 76786 to 76808, 76809 to 76831, 76832 to 76854, 76855 to 76877, 76878 to 76900, 76901 to 76923, 76924 to 76946, 76947, 76740 to 76762, or 77066, or a (preferably functional) fragment, variant, or derivative of any of said sequences. and wherein said fragment, variant or derivative preferably comprises or consists of a nucleic acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to any of these sequences.

[0086] More preferably, the artificial nucleic acid molecule (preferably RNA) of the invention may encode in at least one coding region thereof a CTLA4-derived transmembrane domain comprising or consisting of an amino acid sequence according to SEQ ID NO: 76636, or a (preferably functional) fragment, variant or derivative thereof, said fragment, variant or derivative preferably comprising or consisting of an amino acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to SEQ ID NO: 76636.

[0087] Preferably, the artificial nucleic acid molecule (preferably RNA) of the present invention may comprise, in at least one coding region thereof, a nucleic acid sequence according to any of SEQ ID NOs: 76659, 76705, 76728, 76682, 77004 to 77017, 76774, 76797, 76820, 76843, 76866, 76912, 76889, 76935, 76947, 76751, 77066, or a nucleic acid sequence comprising or consisting of a (preferably functional) fragment, variant or derivative of any of said sequences, said fragment, variant or derivative preferably being , comprising or consisting of a nucleic acid sequence having, in order of increasing preference, at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably at least 70%, more preferably at least 80%, even more preferably at least 85%, even more preferably at least 90%, and most preferably at least 95% or even 97% sequence identity to any of the above sequences.

[0088] The nucleic acid sequences of the RNAs of the present invention can be adapted to enable differentiation of different RNA species in a composition containing more than one RNA species. Preferably, the nucleic acid sequences of the RNAs are adapted without introducing changes to the amino acid sequences encoded by each RNA. Preferably, the nucleic acid sequences of the RNAs are adapted over a stretch of 10 to 200 nucleotides to enable differentiation of different RNA species via PCR-based analytical methods. The adapted stretch can be located in an untranslated region (UTR), a coding sequence for a signal peptide, a coding sequence for an epitope, a linker region, a coding sequence for a helper epitope, the CTLA4 transmembrane domain, the CTLA4 cytoplasmic domain, and the CTLA4 transmembrane cytoplasmic domain. Preferably, the adapted stretch that enables differentiation of different RNA species in a composition is introduced into the CTLA4 transmembrane cytoplasmic domain. Non-limiting examples include a composition containing two different RNA species in which the adapted stretch that enables differentiation is located in the CTLA4 transmembrane cytoplasmic domain (e.g., SEQ ID NO: 77004 and SEQ ID NO: 77005). Further non-limiting examples include compositions comprising three different RNA species in the CTLA4 transmembrane cytoplasmic region where the differentiated stretch of sequences is located (e.g., SEQ ID NO: 77004, SEQ ID NO: 77005, and SEQ ID NO: 77006). Further non-limiting examples include compositions comprising 13 different RNA species in the CTLA4 transmembrane cytoplasmic region where the differentiated stretch of sequences is located (e.g., SEQ ID NO: 77004 through SEQ ID NO: 77017).

[0089] Antigenic peptides or proteins (AN) The artificial nucleic acid molecule (preferably RNA) according to the present invention has at least one coding region thereof encoding at least one antigenic peptide or protein. According to a preferred embodiment, the nucleic acid sequence encoding the at least one antigenic peptide or protein comprises at least one IRST. epm The artificial nucleic acid molecule of the present invention, preferably RNA, can be fused (in frame) to a nucleic acid sequence encoding the amino acid sequence derived from the artificial nucleic acid molecule of the present invention. Thus, expression of the ... epmThis can result in a fusion protein comprising at least one antigenic protein or peptide linked (optionally via a suitable linker) to a further amino acid sequence derived therefrom, which preferably directs the antigenic peptide or protein to MHC class I and more preferably MHC class II processing compartments, resulting in enhanced MHC class I and / or preferably MHC class II presentation. In general, the present invention provides an antigenic fusion protein encoded by an artificial nucleic acid molecule (preferably RNA) of the invention, which comprises any antigenic peptide or protein described herein and any IRST described herein, in any suitable order. epm It is envisaged to combine the sequences with further amino acid sequences derived therefrom, an optional linker, and an optional signal peptide.

[0090] The term "antigenic peptide or protein" generally refers to a peptide or protein that, under appropriate conditions, can interact with / be recognized by components of the immune system (such as antibodies or immune cells). An "antigenic peptide or protein" preferably interacts with / is recognized by components of the immune system via its "epitope" or "antigenic determinant". The term "antigenic peptide or protein" therefore refers to a (poly)peptide that comprises, consists of or is able to provide at least one (functional) epitope. It is particularly envisaged that the artificial nucleic acid molecule (preferably RNA) of the invention encodes a full-length antigenic peptide or protein, or preferably a fragment thereof. Said fragment can comprise or consist of a (functional) epitope of said antigenic peptide or protein. Preferably, said fragment or epitope is expressed in a host cell, directed to the MHC class I and preferably MHC class II processing compartment and recognized by components of the immune system.

[0091] The term "components of the immune system" preferably refers to immune cells, immune cell receptors, and antibodies of the adaptive immune system. An "antigenic peptide or protein" is preferably processed by intracellular machinery and presented to immune cells on MHC molecules, and is preferably capable of resulting in an antigen-specific immune response (e.g., cell-mediated immunity or the formation of antibodies). An "antigenic peptide or protein" may be a translation product of an artificial nucleic acid molecule (preferably RNA) of the present invention.

[0092] The term "epitope" or "antigenic determinant" refers to a portion or fragment of an antigenic peptide or protein that is recognized by the immune system. Such fragments typically contain from about 5 to about 20 or more amino acids. Epitopes can be "conformational" (or "discontinuous"), i.e., composed of a discontinuous sequence of amino acids in the antigenic peptide or protein from which they are derived, but organized into a three-dimensional structure, such as an MHC complex, or "linear" (i.e., consisting of a continuous sequence of amino acids in the antigenic peptide or protein from which they are derived). The term "epitope" generally encompasses "T cell epitopes" (recognized by T cells via T cell receptors) and "B cell epitopes" (recognized by B cells via B cell receptors). "B cell epitopes" are typically located on the outer surface of a (native) protein or peptide antigen as defined herein and can preferably comprise or consist of 5 to 15 amino acids, more preferably 5 to 12 amino acids, and even more preferably 6 to 9 amino acids. A "T cell epitope" is typically recognized by MHC-I- or MHC-II-binding T cells, i.e., as a complex formed by an antigenic protein or peptide fragment containing the epitope and an MHC-I or MHC-II surface molecule. A "T cell epitope" typically has a length of about 6 to about 20 or more amino acids, and T cell epitopes presented by MHC class I molecules are preferably about 8 to about 10 amino acids in length, e.g., 8, 9, or 10 (or 11 or 12) amino acids in length. T cell epitopes presented by MHC class II molecules are preferably about 13 or more amino acids in length, e.g., 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, or more amino acids. In the context of the present invention, the term "epitope" may in particular refer to a T-cell epitope.

[0093] When referring herein to an artificial nucleic acid molecule (preferably RNA) encoding "at least one antigenic peptide or protein," it is assumed that the artificial nucleic acid molecule may encode one or more full-length (wild-type / mutant / derivative) antigenic peptides or proteins, or one or more fragments, in particular (functional) epitopes, of the (wild-type / mutant / derivative) antigenic peptides or proteins. The (wild-type / mutant / derivative) antigenic peptides or proteins, or fragments thereof, preferably comprise, consist of, or provide at least one (functional) epitope. That is, the (wild-type / mutant / derivative) antigenic peptides or proteins, or fragments thereof, preferably comprise or consist of a native epitope (preferably recognized by B cells), or are capable of being processed and presented by MHC-I or MHC-II molecules and providing an MHC-binding epitope (preferably recognized by T cells). A "functional" epitope refers to an epitope that can induce a desired adaptive immune response in a subject.

[0094] At least one antigenic peptide or protein encoded by the artificial nucleic acid molecule (preferably RNA) of the present invention comprises at least one IRST epm The derived amino acid sequence can be optionally fused to or contained at the N-terminus, C-terminus, or within the sequence via a suitable peptide linker (providing an "antigenic fusion protein" as defined herein). Thus, the artificial nucleic acid molecule (preferably RNA) of the present invention can be an IRST as defined herein. epm Specifically contemplated herein are derived amino acid sequences (including antigenic peptides or proteins) that encode and produce functional epitopes as defined herein.

[0095] The selection of an appropriate antigenic peptide or protein generally depends on the condition or disease to be treated or prevented. In general, an artificial nucleic acid molecule (preferably RNA) can encode any antigenic peptide or protein (or any desired combination of antigenic peptides or proteins) in at least one coding region thereof. It is also contemplated herein to provide artificial nucleic acid molecules, preferably RNA, that encode any combination of multiple at least 2, 3, 4, 5, 6, 7, 8, 9, or 10 or more (identical or different) antigenic peptides or proteins (preferably as defined herein, see e.g., multivalent vaccines). Preferred antigenic peptides and proteins are specifically set forth below.

[0096] Antigenic peptides or proteins derived from tumor antigens According to a preferred embodiment, the artificial nucleic acid molecule (preferably RNA) according to the invention encodes, in at least one of its coding regions, at least one antigenic peptide or protein derived from a tumor antigen. The term "tumor antigen" refers to an antigen derived from or associated with a (preferably malignant) tumor or cancerous disease. As used herein, the terms "cancer" and "tumor" are used interchangeably to refer to a neoplasm characterized by uncontrolled, usually rapid, proliferation of cells that tend to invade surrounding tissues and metastasize to distant body sites. This term includes benign and malignant neoplasms. Malignant cancers are usually characterized by anaplasia, invasion, and metastasis, while benign malignancies are usually lacking these characteristics. The terms "cancer" and "tumor" particularly refer to neoplasms characterized by tumor growth, but also cancers of the blood and lymphatic system. "Tumor antigens" are typically derived from tumor / cancer cells, preferably mammalian tumor / cancer cells, and can be located within or on the surface of tumor cells derived from mammalian, preferably human, tumors, e.g., systemic or solid tumors. "Tumor antigens" generally include tumor-specific antigens (TSAs) and tumor-associated antigens (TAAs). TSAs are presented only by tumor cells, not by normal "healthy" cells. They usually result from tumor-specific mutations. TAAs are more common, but are usually presented by both tumor and healthy cells. These antigens can be recognized and the antigen-presenting cells can be destroyed by cytotoxic T cells. Furthermore, tumor antigens can also be present on the surface of tumors, for example, in the form of mutated receptors. In this case, they can be recognized by antibodies.

[0097] Preferably, the at least one antigenic peptide or protein encoded by at least one coding region of an artificial nucleic acid molecule (preferably RNA) of the invention can be derived from the following: melanoma antigen recognized by T cells 1, eukaryotic translation initiation factor 4 gamma 1, histone H1.2, cyclin-dependent kinase 4, 40S ribosomal protein S21, DNA replication licensing factor MCM4, actin, gamma intestinal smooth muscle, melanocyte protein PMEL, phospholipid transfer protein, vimentin, eukaryotic translation initiation factor 3 subunit D, melanoma-associated antigen 1, fructose bisphosphate aldolase A, guanine nucleotide-binding protein G(I) / G(S) / G(T) subunit beta 2, ER membrane protein complex subunit 7, actin, cytoplasmic 1, high mobility group protein B1, coiled-coil-helix-coiled-coil-helix domain-containing protein 2. 2), HLA class II histocompatibility antigens, DP beta 1 chain, 60S ribosomal protein L13, thymosin beta 10, guanine nucleotide-binding protein G(s) subunit alpha isoforms short, guanine nucleotide-binding protein subunit beta 2-like 1, Bax inhibitor 1, Wilms tumor protein, gamma secretase C-terminal fragment 59, thymidylate synthase, 60S ribosomal protein L10, Lys-63-specific deubiquitinating enzyme BRCC36, myelin basic protein, HLA class I histocompatibility antigens, A-2 alpha chain, regulator complex protein LAMTOR5, 40S ribosomal protein S25, POTE ankyrin domain family member F, mortality factor 4-like protein 11), melanoma-associated antigen 3, heme oxygenase 1, G2 / mitosis-specific cyclin-B1, proteasome subunit alpha type 5, protein THEMIS2, fatty acid synthase, mammaglobin A, actin-related protein 2, 60S ribosomal protein L28, 60S acidic ribosomal protein P0, cellular tumor antigen p53, proteasome subunit beta type 3, DNA (cytosine-5)-methyltransferase 1, catenin beta-1, myosin-9, reticulocalvin-2, heterogeneous nuclear ribonucleoprotein A1, 60S ribosomal protein L8, ribonucleoside diphosphate reductase subunit M2, melanoma-associated antigen B2, protein SSX2, proliferating cell nuclear antigen, receptor tyrosine-protein kinase erbB-2, heat shock protein HSP90-beta, ornithine decarboxylase, ubiquitin-conjugating enzyme E2 E3, 60S ribosomal protein L19, small nuclear ribonucleoprotein-related proteins B and B', elongation factor 2, putative small nuclear ribonucleoprotein G-like protein 15, serine-tRNA ligase, cytoplasm, beta-2-microglobulin, ADP / ATP translocase 2, acyl-CoA desaturase, ubiquitin-60S ribosomal protein L40, prelamin-A / C, heat shock cognate 71 kDa protein, melanoma-associated antigen 2, beta-adrenergic receptor kinase 1, farnesyl pyrophosphate synthase, 40S ribosomal protein S8, glutamate carboxypeptidase 2, serine / threonine protein phosphatase PP1-beta catalytic subunit, ATP-binding cassette subfamily F member 2, gamma interferon-inducible lysosomal thiol reductase, stress-70 protein, mitochondria, mucin-1, RacGTPase-activating protein 1, HLA class I histocompatibility antigen, B-39 alpha chain, 40S ribosomal protein S16, tyrosinase, HLA class I histocompatibility antigen, alpha chain E, bifunctional purine biosynthesis protein PURH, transferrin receptor protein 1, ELAV-like protein 1, U1 small nuclear ribonucleoprotein A, heat shock 70 kDa protein 1-like, HLA class II histocompatibility antigen, DR alpha chain, T-complex protein 1 subunit alpha, carcinoembryonic antigen-related cell adhesion molecule 5, histone H2AX, lamin-B1, 60S acidic ribosomal protein P2, actin, cytoplasmic 2, B lymphocyte antigen CD20, actin, aortic smooth muscle, putative global transcription activator SNF2L2, myo Tubularin-related protein 5, proteasome subunit beta type-1, 60S ribosomal protein L7a, histone H3.3, 60S ribosomal protein L24, 40S ribosomal protein S3, HLA class I histocompatibility antigen, Cw-7 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, serine / threonine protein kinase Sgk1, serine / threonine protein phosphatase PP1-alpha catalytic subunit, heterogeneous nuclear ribonucleoprotein K, L-dopachrome tautomerase, protein flightless-1 homolog, dual specificity protein phosphatase 5, TSC22 domain family protein 3, cancer / testis antigen 1, serine / threonine protein phosphatase 2A65 kDa regulatory subunit A alpha isoform, protein transport protein Sec23B, protein transport protein Sec23A, CD59 glycoprotein, collagen alpha-5(IV) chain, AT-rich interactive domain-containing protein 3A, polypyrimidine tract-binding protein 1, spermine synthase, glutamine-fructose-6-phosphate aminotransferase [isomerization]1, eukaryotic translation initiation factor 3 subunit L, protein BTG2, DNA-directed RNA polymerase II subunit RPB1, myeloblastin, HLA class I histocompatibility antigen, Cw-3 alpha chain, importin subunit alpha-5, rRNA 2'-O-methyltransferase fibrillarin, cyclin-A2, probable ATP-dependent RNA helicase DDX5, cytochrome c oxidase subunit 2, IST1 homolog, 60S ribosomal protein L35, triosephosphate isomerase, sorting nexin-5, melanoma-associated antigen 4, ubiquilin-4, HLA class I histocompatibility antigen, Cw-2 alpha chain, interferon-induced transmembrane protein 1, amyloid beta A4 protein, heat shock 70 kDa protein 1B, HLA class I histocompatibility antigen, A-1 alpha chain, G antigen 12H, transaldolase, putative pre-mRNA splicing factor ATP-dependent RNA helicase DHX16, 14-3-3 protein gamma, serine / threonine protein kinase SMG1, cyclin-L1, glyceraldehyde-3-phosphate dehydrogenase, very long-chain fatty acid protein 1 elongation of very long chain fatty acids protein 1, microtubule-associated protein RP / EB family member 2, T-complex protein 1 subunit epsilon, sphingolipid delta(4)-desaturase DES1, and elongation of very long chain fatty acids protein 55), ORM1-like protein 2, baculovirus IAP repeat-containing protein 7, E3 ubiquitin protein ligase TRIM68, putative HTLV-1-associated endogenous sequence, myelin proteolipid protein, SAM and SH3 domain-containing protein 1, E3 ubiquitin-protein ligase SIAH1, muscleblind-like protein 2, annexin A1, nuclear ubiquitous casein and cyclin-dependent kinase substrate 1, pleiotropic regulator 1 1), NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3, CD99 antigen, guanine nucleotide-binding protein G(o) subunit alpha, calsyntenin-1, GPI transamidase component PIG-T, perilipin-3, WD40 repeat-containing protein SMU1, protein S100-B, annexin A11, histone H2B type 2-F, calmodulin, phosphoinositide-3-kinase interacting protein 1, THO complex subunit 4, neuroblastoma differentiation-associated protein AHNAK, phosphoserine aminotransferase, histone deacetylase 7, gelsolin, tight junction protein ZO-1, NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial endothelial cell membrane protein 1 (MIT) Andria, LIM domain transcription factor LMO4, spectrin beta chain, non-erythroid 1, NADH dehydrogenase [ubiquinone] 1 subunit C2, testican-2, alpha-addacin, V-type proton ATPase subunit F, 40S ribosomal protein SA, Bcl-2-related transcription factor 1, ATP synthase-binding factor 6, mitochondria, phosphatidylethanolamine-binding protein 1, 40S ribosomal protein S29, septin-2, methyl-CpG-binding domain protein 3, transformation / transcription domain-associated protein, transcription factor HES-1, paralemmin-2, sodium / potassium transport ATPase subunit alpha-3, stathmin, heterogeneous nuclear ribonucleoprotein L-like, nodal modulator 33), interferon-induced GTP-binding protein Mx2, neuronal membrane glycoprotein M6-b, contactin-1, cytosolic nonspecific dipeptidase, noelin-2, serine / threonine protein kinase DCLK1, U2 small nuclear ribonucleoprotein B, nuclear autoantigen sperm protein, 60S ribosomal protein L5, endoplasmic reticulum-Golgi intermediate compartment protein 1, programmed cell death protein 4, endoplasmin, eukaryotic translation initiation factor 3 subunit F, cofilin-1, pyruvate kinase PKM, dolicholyl diphosphooligosaccharide protein glycosyltransferase subunit STT3A, 5'(3')-deoxyribonucleotidase, cytosolic, CKLF-like MARVEL transmembrane domain-containing protein 6, cleavage and polyadenylation specificity factor subunit 1 1), neutral amino acid transporter B(0), protein PRRC1, provably ATP-dependent RNA helicase DDX49, nuclear pore complex protein Nup160, ATP synthase subunit beta, mitochondria, signal peptidase complex subunit 2, protein kinase C iota type, histone acetyltransferase p300, histone H2A type 1-A, small nuclear ribonucleoprotein G, nucleosome assembly protein 1-like 1, 40S ribosomal protein S11, structural maintenance of chromosomes protein 3 3), centrin-2, GTP-binding nuclear protein Ran, 40S ribosomal protein S3a, ATP-dependent RNA helicase A, T complex protein 1 subunit eta, proteasome-associated protein ECM29 homolog, GPN loop GTPase 1, 60S ribosomal protein L10a, heterogeneous nuclear ribonucleoprotein C1 / C2, hydroxymethylglutaryl-CoA synthase, cytoplasm, sterol O-acyltransferase 1, tuberin, eukaryotic Biological translation elongation factor 1 epsilon-1, phosphoinositide 3-kinase regulatory subunit 4, annexin A2, U2 small nuclear ribonucleoprotein A', serine / threonine protein kinase SIK1, nucleolin, L-lactate dehydrogenase B chain, L-lactate dehydrogenase A chain, Aladdin, microtubule-associated protein 4, peroxiredoxin-5, mitochondria, HLA class I histocompatibility antigen, B-7 alpha chain, carbamoyl phosphate synthase [ammonia], mitochondria, coiled-coil domain-containing protein 12, kinectin, Ke latin, type I cytoskeleton 18, 40S ribosomal protein S5, nucleosome assembly protein 1-like 4, U4 / U6 small nuclear ribonucleoprotein Prp31, ELAV-like protein 3, small histocompatibility protein HA-1, low-affinity immunoglobulin epsilon Fc receptor, 26S proteasome non-ATPase regulatory subunit 2, ATP-dependent RNA helicase DDX3X, putative homeodomain transcription factor 2, transcription factor BTF3, ribosome biogenesis protein BRX1 homolog, HLA class I histocompatibility antigen, B-8 alpha chain, dynamin-2 , ELAV-like protein 4, ATP-dependent RNA helicase DDX3Y, histone demethylase UTY, Pumilio homolog 3, histone H4, histone H3.2, protein S100-A9, macrophage migration inhibitory factor, hemoglobin subunit alpha, 40S ribosomal protein S17, collagen alpha-1(I) chain, collagen alpha-2(I) chain, T-complex protein 1 subunit theta, Cullin-1, DNA replication licensing factor MCM7, BolA-like protein 2, DNA topoisomerase ATPase 2-beta, proteasome subunit alpha type-4, bifunctional glutamate / proline-tRNA ligase, sodium / potassium transport ATPase subunit alpha-1, MICOS complex subunit MIC60, peptidyl-prolyl cis-trans isomerase A, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, zinc finger MYM-type protein 2, transforming protein RhoA, putative endoplasmin-like protein, plasminogen activator inhibitor 1 RNA-binding protein,Uncharacterized protein C20orf24, importin subunit beta-1, melanoma-associated antigen D2, protein Spindly, coatomer subunit epsilon, targeting protein for Xklp2, H / ACA ribonucleoprotein complex subunit 4, H / ACA ribonucleoprotein complex subunit 3, cerebellar degeneration-associated protein 2, exocyst complex component 2, 1-phosphatidylinositol 3-phosphate 5-kinase, proteasome activator complex subunit 3, nuclear pore complex protein Nup205, neurogenic locus Notch homolog protein Protein 1, lysosomal protective protein, serine / threonine protein kinase 38-like, alpha-1B glycoprotein, neuropilin-2, calreticulin, filamin A, syntenin-1, cathepsin D, HLA class I histocompatibility antigen, B-51 alpha chain, profilin-1, lymphocyte-specific protein 1, synemin, insulin receptor substrate 2, ETS translocation variant 5, E3 ubiquitin protein ligase Mdm2, U1 small nuclear ribonucleoprotein 70 kDa, coatomer subunit G mannose 1, T complex protein 1 subunit gamma, DCN1-like protein 1, U3 small nuclear ribonucleoprotein protein IMP3, phosphoglycerate kinase 1, diphthamide biosynthesis protein 1, methionine aminopeptidase 2, dipeptidyl peptidase 9, chloride intracellular channel protein 4, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, acyl protein thioesterase 2, 26S proteasome non-ATPase regulatory subunit 14, Golgi apparatus-specific blocker Refeldin A-resistant guanine nucleotide exchange factor 1, E3 ubiquitin protein ligase BRE1A, Abl interacting factor 2, nuclear pore complex protein Nup88, thioredoxin-like protein 4A, transmembrane emp24 domain-containing protein 2, glycogen phosphorylase, muscle morphology, junction plakoglobin, dolicholyl diphosphooligosaccharide protein glycosyltransferase subunit 2, putative eukaryotic translation initiation factor 2 subunit 3-like protein,Serine / threonine protein kinase / endoribonuclease IRE1, interferon-induced GTP-binding protein Mx1, mitotic spindle-associated MMXD complex subunit MIP18, sulfiredoxin-1, nucleolar GTP-binding protein 1, 10 kDa heat shock protein, mitochondria, anoctamin-6, nucleolar preribosomal-associated protein 1, RNA-binding protein 34, S-adenosylmethionine synthase isoform type 2, transmembrane protein 209, HLA class I histocompatibility antigen, B-13 alpha chain, ubiquitin carboxyl-terminal hydrolase 11, ataxin-10, vacuolar protein sorting-associated protein 13B, SWI4 Suppressor of 1 homologue, Golgin subfamily A member 7, stomatin-like protein 2, mitochondria, nuclear pore complex protein Nup107, N-alpha-acetyltransferase 10, cytochrome c oxidase subunit 6B1, general transcription factor II-I repeat domain-containing protein 2B, heterogeneous nuclear ribonucleoprotein A0, condensin complex subunit 3, regulation of nuclear pre-mRNA domain-containing protein 1A, helicase SRCAP, spartin, uncharacterized protein ZMYM6NB, CLIP-associated protein 1, alpha actinin-4, nucleolar protein 58, serine / threonine protein kinase Kist, transcription factor Sp2, apolipoprotein L1, tankyrase 2, uncharacterized protein C19orf43, heat shock protein HSP90-alpha, X-ray repair cross-complementing protein 5 5), nucleolar protein 7, U5 small nuclear ribonucleoprotein 200kDa helicase, 15kDa selenoprotein, ribosomal RNA processing protein 1 homolog B, 116kDa U5 small nuclear ribonucleoprotein component, tumor-associated antigen Ma1, retinoic acid-inducible protein 1, ADP-ribosylation factor GTPase-activating protein 2, nucleolar protein 56, RNA-binding protein 14, eukaryotic initiation factor 4A-I, septin-7, protein polybromo-1, annexin A4, centromeric protein F, 60S ribosomal protein L22-like 1, histone H2B type 1-A,ADP-dependent glucokinase, heterogeneous nuclear ribonucleoprotein U, high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, E3 ubiquitin protein ligase UBR2, m7GpppX diphosphatase, microtubule-actin cross-linking factor 1, isoforms 1 / 2 / 3 / 5, YTH domain-containing protein 1, eukaryotic translation initiation factor 5A-1, activating transcription factor 7-interacting protein 1, transmembrane protein 258, U3 small nucleolar RNA-associated protein 6 homolog, nucleolus RNA helicase 2, DNA-directed RNA polymerase II subunit RPB7, RRP12-like protein, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, 26S protease regulatory subunit 4, nucleolar protein 11, prothymosin alpha, bezatin, protein AF-10, negative elongation factor C / D, transcription factor E2F1, RNA-binding protein 6, eukaryotic translation initiation factor 4 gamma 3, adjacent to the BRCA1 gene protein (Next to BRCA1 gene 1 protein, mitochondrial import receptor subunit TOM7 homolog, heterogeneous nuclear ribonucleoprotein U-like protein 1, poly[ADP-ribose] polymerase 1, eukaryotic translation initiation factor 3 subunit C, condensin 2 complex subunit G2, signal transducer and activator of transcription 1-alpha / beta, signal transducer and activator of transcription 3, ataxin 2-like protein, G-patch domain-containing protein 4, Golgi resident protein GCP60, AP-1 complex subunit sigma-3, cleavage stimulator subunit 3, ATP-dependent RNA helicase DDX24, Mediator of RNA polymerase II transcription subunit 23, sorting and assembly machinery component 50 homolog homolog), protein LAP2, spectrin beta chain, erythrocyte, E3 ubiquitin protein ligase RBBP6, 40S ribosomal protein S18, keratinocyte-associated protein 2, dolicholyl diphosphooligosaccharide protein glycosyltransferase subunit DAD1,Minor histocompatibility antigen H13, catenin alpha-2, TBC1 domain family member 31, poly[ADP-ribose] polymerase 4, basic leucine zipper and W2 domain-containing protein 1, neutral alpha-glucosidase AB, RuvB-like 2, protein MCM10 homolog, plexin-C1, DNA repair protein XRCC1, protein AATF, short transient receptor potential channel 4-associated protein, cell cycle progression protein 1, dihydrofolate reductase, mitochondria, splicing factor 3A subunit 3, RNMT activating miniprotein, coatomer subunit delta, coatomer subunit alpha, mothers against decapentaplegic homolog 9 9), ubiquitin-like protein FUBI, lysine tRNA ligase, cytochrome c oxidase subunit 6A1, mitochondria, polycomb protein SUZ12, SNARE-associated protein Snapin, signal recognition particle 54 kDa protein, putative JmjC domain-containing histone demethylating protein 2C, putative ATP-dependent RNA helicase DDX11-like protein 8, general transcription factor 3C polypeptide 1, and Tonsoku-like protein protein), nuclear pore complex protein Nup214, ATP-dependent 6-phosphofructokinase, platelet type, alpha-endosulfine, 60S ribosomal protein L26, DNA mismatch repair protein Msh2, chromodomain-helicase-DNA binding protein 8, cell division cycle protein 27 homolog, transmembrane protein 43, clathrin heavy chain 1, disintegrin and metalloproteinase domain-containing protein 10, protein CASP, Gem-associated protein 5, ribosome biogenesis protein LAS1L, WD repeat-containing protein 34, DnaJ homolog subfamily B member 4, tyrosine protein kinase Fyn, activating signal cointegrator 1, putative mitochondrial import inner membrane translocase subunit Tim23B,Peroxisomal acyl-coenzyme A oxidase 1, HLA class II histocompatibility antigens, DO alpha chain, poly[ADP-ribose] polymerase 14, mediator of RNA polymerase II transcription subunit 18, 60S ribosomal protein L7, zinc finger protein 548, Protein FAM32A, heat shock protein HSP90-alpha A2, Myc-related zinc finger protein, heterogeneous nuclear ribonucleoprotein A2 / B1, type V proton ATPase 116 kDa subunit a isoform 4, zinc finger protein 770, protein SSXT, zinc finger and BTB domain-containing protein 43, signaling adapter molecule 2, Cirhin, DTW domain-containing protein 1, bone morphogenetic protein receptor type 2, dedicator of cytokinesis protein 7 7), SUMO-activating enzyme subunit 1, superkiller virucidal activity 2-like 2, 60S ribosomal protein L15, transcription elongation factor SPT6, 60S ribosomal protein L18a, catalase, tuftelin-interacting protein 11, hepatocellular carcinoma-derived growth factor-related protein 2, putative annexin A2-like protein, protein transport protein Sec16A, transcription elongation factor SPT5, splicing factor 3B subunit 4, serine / threonine protein kinase 17B, pre-mRNA splicing factor CWC22 homolog, serine / threonine protein kinase mTOR, E3 ubiquitin protein ligase RNF213, RNA polymerase I-specific transcription initiation factor RRN3, nuclear receptor corepressor 2, HLA class II histocompatibility antigen, DQ alpha 1 chain, nuclear pore membrane glycoprotein 210 210), NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, lysine-specific histone demethylase 1A, thioredoxin-interacting protein, 60S ribosomal protein L27, putative elongation factor 1 alpha-like 3, long-chain fatty acid CoA ligase 4, signal recognition particle receptor subunit alpha, embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, DNA-directed RNA polymerase I, II, and III subunit RPABC5, dystonin, 60S ribosomal protein L23a, ATP citrate synthase, protein quaking (Proteinquaking), homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, transducin-like enhancer protein 2, gamma interferon-inducible protein 16, cytoplasmic dynein 1 heavy chain 1, staphylococcal nuclease domain-containing protein 1, thioredoxin, ribonucleoside diphosphate reductase large subunit, lamin B receptor, asparagine synthase [glutamine hydrolysis], heterogeneous nuclear ribonucleoprotein L, caprin-1, DNA-dependent protein kinase catalytic subunit, RAC-betacellulosic acid Serine / threonine protein kinase, replication factor C subunit 1, pre-mRNA processing factor 40 homolog A, helicase-like transcription factor, pre-mRNA splicing factor RBM22, kinesin-like protein KIF18A, vacuolar protein sorting-associated protein 13A, raftlin, coiled-coil domain-containing protein 94, signal-induced proliferation-associated 1-like protein 2, pre-mRNA processing splicing factor 8, serine / arginine-rich splicing factor 3, T complex protein 1 subunit zeta-2, and periphytonuclear endothelial cell membrane protein 1 (PEF1). Lin-1, metastasis-associated protein MTA2, spataxin, heterogeneous nuclear ribonucleoprotein A / B, protein RRP5 homolog, 60 kDa heat shock protein, mitochondria, protein transport protein Sec61 subunit beta, 40S ribosomal protein S19, protein DEK, cyclin-dependent kinase regulatory subunit 2, protein disulfide-isomerase A3, heterogeneous nuclear ribonucleoprotein R, lamina-associated polypeptide 2, isoform alpha, ATP synthase F(0) complex subunit C1, Mitochondria, cytospin-A, zinc finger protein 557, zinc finger protein 669, WD repeat-containing protein 6, signal transducer and activator of transcription 6, antigenic peptide transporter 1, retinoic acid receptor RXR-gamma, eukaryotic translation initiation factor 2 alpha kinase 1, CDK5 regulatory subunit-associated protein 2, trifunctional purine biosynthesis protein adenosine 3, R3H domain-containing protein 4, WD repeat-containing protein 27, UAP56 interactor, histone acetyltransferase KAT8, putative tRNAN6-Adenosine threonylcarbamoyltransferase, deoxynucleotidyltransferase terminal interacting protein 2, serpin B8, ATP synthase subunit alpha, mitochondrial, 1,4-alpha glucan branching enzyme, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, putative threonine-tRNA ligase 2, cytoplasmic, coiled-coil domain-containing protein 127, glucosylceramidase, ATPase family AAA domain-containing protein 5, casein kinase II subunit alpha, gamma tubulin complex component 2, integrator complex subunit 11, Pogo transposable element with KRAB domain, nuclear factor erythroid 2-related factor 2, serpin B9, folliculin-interacting protein 2, exportin 5, protein transport protein Sec61 subunit gamma, brefeldin A-inhibitory guanine nucleotide exchange protein 1, charged multivesicular body protein 5 5), calpain small subunit 1, PR domain zinc finger protein 15, DnaJ homolog subfamily C member 11, ubiquitin-conjugating enzyme E2 variant 3, spermatid perinuclear RNA-binding protein, cytosolic carboxypeptidase 1, DNA repair protein RAD51 homolog 1, eukaryotic translation initiation factor 3 subunit C-like protein, methionine aminopeptidase 1, tyrosine protein phosphatase non-receptor type 11, protein UXT, nalidilisin, Mediator of RNA polymerase II transcription subunit 13, Absent in melanoma 1 protein, ubiquitin carboxyl-terminal hydrolase 22, ADP-sugar pyrophosphatase, RasGTPase-activating protein-binding protein 1, nuclear pore complex protein Nup155, zinc finger protein 550, zinc finger protein 674, nucleoporin NUP188 homolog, signal recognition particle subunit SRP72, oxysterol-binding protein-related protein 8, putative cation-transporting ATPase 13A3, band 4.1-like protein 2, 26S proteasome non-ATPase regulatory subunit 13, cytochrome b-c1 complex subunit 9, mitotic checkpoint protein BUB3, exocyst complex Coalescence component 4, patatin-like phospholipase domain-containing protein 2, tubulin beta-4A chain, ATP-binding cassette subfamily F member 3, pre-mRNA splicing factor ATP-dependent RNA helicase DHX15, actin-associated protein 2 / 3 complex subunit 2, protein FAM60A, chromobox protein homolog 6, splicing factor 3B subunit 1, FAS-associated factor 2, 26S proteasome non-ATPase regulatory subunit 3, histone deacetylase 9, F-box only protein 5, ATP-binding cassette subfamily D member 1, V-type proton ATPase subunit d1, enhancer of rudimentary homologhomolog), ATP synthase subunit epsilon-like protein, mitochondria, polyadenylate-binding protein 1, protein OS-9, interferon induction, double-stranded RNA-activated protein kinase, alpha-taxillin, tetratricopeptide repeat protein 9C, transmembrane emp24 domain-containing protein 4, non-receptor tyrosine protein kinase TYK2, E3 ubiquitin protein ligase AMFR, proteasome subunit alpha type 2, nucleolysin TIA-1 isoform p40, nucleolysin TIAR, kinesin-like protein KIF20A, non-specific lipid transfer protein, ectonucleoside triphosphate diphosphohydrolase 1, FACT complex subunit SSRP1, two stranded RNA-binding protein Staufen homolog 1, serine / threonine protein phosphatase 6 regulatory subunit 3, SUMO-specific isopeptidase USPL1, 5'-nucleotidase domain-containing protein 1, serine / arginine-rich splicing factor 6, serine / threonine protein kinase 17A, A-kinase anchor protein 2, zinc finger protein Rlf, histone lysine N-methyltransferase SETD2, nesprin-2, uncharacterized C14orf119, cyclin G-related kinase, peroxisomal membrane protein 2, nucleoporin GLE1, nuclear pore complex protein Nup93, 60S ribosomal export protein NMD3, 14 kDa phosphohistidine phosphatase, MKI67 FHA domain-interacting nucleolar phosphoprotein, kinesin-associated protein 3, U4 / U6 small nuclear ribonucleoprotein Prp4, transmembrane emp24 domain-containing protein 3, E3 ubiquitin protein ligase MARCH7, midasin, and Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 22), zinc finger protein 330, protein FAM208B, heat shock 70 kDa protein 14, COP9 signalosome complex subunit 6, axin 1, proteasome subunit beta type 8, dedicator of cytokinesis protein 11, mitochondrial Rho GTPase 2, cysteine-rich PDZ-binding protein, exosome complex exonuclease RRP44, collagen type IV alpha 3-binding protein, vigilin, WD repeat-containing protein 1, cytoplasmic FMR1-interacting protein 1, eukaryotic translation initiation factor 3 subunit I, epidermal growth factor receptor substrate 15, E3 ubiquitin protein ligase Topors, tubulin beta chain, cohesin subunit SA-2, phosphatidylinositol 3,4,5-phosphate-dependent Rac exchanger 1 protein, phospholipid transport ATPase IG, vacuolar protein sorting-associated protein 26A, syntaxin-binding protein 3, centrosomal protein Protein CEP57L1, pleckstrin homology domain-containing family B member 2, zinc finger protein 706, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2, V-type proton ATPase subunit E2, 40S ribosomal protein S13, cation-independent mannose-6-phosphate receptor, nucleoporin Nup37, RNA polymerase II elongation factor ELL, heterogeneous nuclear ribonucleoprotein F, tetratricopeptide repeat protein 13, tapasin, condensin-2 complex subunit D3, endoplasmic reticulum-Golgi intermediate compartment protein 3, threonine-tRNA ligase, cytoplasmic, choline / ethanolamine phosphotransferase 1, 28S ribosomal protein Protein S17, mitochondria, protein Niban, ubiquitin carboxyl-terminal hydrolase 7, E3 ubiquitin protein ligase RNF19A, interleukin enhancer-binding factor 2, transitional endoplasmic reticulum ATPase, nuclear factor NF-kappa-B p100 subunit, phospholipase D2, acidic fibroblast growth factor intracellular binding protein, alanine-tRNA ligase, cytoplasm, histone-lysine N-methyltransferase 2C, attractin, histone-lysine N-methyltransferase, H3 lysine-79 specific, dynamin-1-like protein, pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, chromodomain-helicase-DNA-binding protein 7, polypyrimidine tract-binding protein 3, HLA class I histocompatibility antigen, B-52 alpha chain, cell division cycle-associated 7-like protein, mediator of RNA polymerase II transcription subunit 10, hypoxia-inducible factor 1-alpha, metastasis-associated protein MTA3, oxysterol-binding protein-associated protein 3, tRNA(adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, nucleolar complex protein 4 homolog, geminin, chromodomain helicase DNA-binding protein 1-like, and skeletal muscle growth protein 5 (Up-regulated in during skeletal muscle growth protein 5), integrator complex subunit 3, mitogen-activated protein kinase 6, RNA-binding motif protein, X-linked-like-1, serine / threonine protein kinase PLK1, glycoprotein endo alpha-1,2-mannosidase-like protein, cold-inducible RNA-binding protein, DNA mismatch repair protein Msh6, serine hydroxymethyltransferase, cytosol, store-operated calcium entry-associated regulatory factor, FACT complex subunit SPT16, histone-lysine N-methyltransferase EZH1, trafficking protein particle complex subunit 4, DnaJ homolog subfamily C member 3,Meckelin, serine / threonine protein kinase pim-2, RNA-binding protein 7, glutathione S-transferase Mu2, protein patched homolog 1, ARF GTPase-activating protein GIT2, thioredoxin-related transmembrane protein 2, zinc finger CCCH domain-containing protein 18, putative ATP-dependent RNA helicase DDX47, eukaryotic translation initiation factor 2 subunit 3, AP-1 complex subunit beta 1, septin 6, DNA topoisomerase 2 alpha, coilin, ATPase family AAA domain-containing protein 2, choline phosphate cytidylyltransferase A, serine / threonine protein kinase pim-1, death-associated protein kinase 2, transcription termination factor 2, C-1-tetrahydrofolate synthase, cytoplasmic, major histocompatibility complex class I-related gene protein, Delta(24)-sterol reductase, protein SET, constitutive coactivator of PPAR gamma-like protein 1, DNA replication complex GINS protein PSF1, AP-1 complex subunit mu-2, dolichol phosphate mannosyltransferase subunit 1, heterogeneous nuclear ribonucleoprotein M, plus tin-3, THO complex subunit 2, 60S ribosomal protein L4, hexokinase-2, ribosome-binding protein 1, proteasome subunit beta type 5, anaphase-promoting complex subunit 2, protein tyrosine kinase 2 beta, NEDD8 ultimate buster 1, baculovirus IAP repeat-containing protein 6, E3 ubiquitin protein ligase CBL-B, basigin, phosphatidylinositol 4 kinase type 2-beta, histone-binding protein R BBP7, high mobility group protein B3, lymphocyte antigen 75, putative RRN3-like protein RRN3P1, chloride intracellular channel protein 1, transmembrane emp24 domain-containing protein 7, myosin light polypeptide 6, proteasome inhibitor PI31 subunit, kinesin-like protein KIF20B, rRNA processing protein FCF1 homolog, cyclin-dependent kinase 6, filamin A, replication protein A 32kDa subunit, ATP-dependent RNA helicase DHX8,Cysteine ​​and glycine-rich protein 1, ER membrane protein complex subunit 2, cleavage stimulatory factor subunit 1, exportin-2, protein KIAA0100, cyclin-dependent kinase inhibitor 3, eukaryotic translation initiation factor 3 subunit M, sigma non-opioid intracellular receptor 1, DNA repair protein RAD50, nuclear pore complex protein Nup153, protein SCO1 homolog, mitochondria, F-box / LRR repeat protein 3, von Willebrand factor, DNA nucleotidyl exotransferase, endothelial differentiation-associated factor 1, serine / arginine-rich splicing factor 9, putative E3 ubiquitin protein ligase macorin-2, antigen KI-67, RNA polymerase Mediator of transcription enzyme II subunit 17, non-canonical poly(A) RNA polymerase PAPD5, interleukin-9 receptor, trafficking protein particle complex subunit 5, magnesium transporter protein 1, transforming acidic coiled-coil-containing protein 3, membrane-associated tyrosine- and threonine-specific cdc2 inhibitory kinase, Ig kappa chain C region, multifunctional protein ADE2, TPT1-like protein, AP-5 complex subunit zeta-1, protein transport protein Sec31A, DnaJ homolog subfamily C member 7, WD repeat-containing protein 82, Disco-interacting protein 2 homolog A, DNA replication licensing factor MCM5, and Discus large homolog 1 (Disks) large homolog 1), ubiquitin-conjugating enzyme E2 J1, nucleolar transcription factor 1, citrate synthase, mitochondria, GMP reductase 2, single Ig IL-1-related receptor, sulfhydryl oxidase 1, cyclin D1-binding protein 1, HLA class II histocompatibility complex, DRB1-15 beta chain, pre-mRNA-splicing factor ISY1 homolog, CUGBP Elav-like family member 1, gamma secretase subunit PEN-2, tyrosine protein kinase BAZ1B, influenza virus NS1A-binding protein, target of rapamycin complex subunit LST8, splicing factor 3B subunit 2, importin subunit alpha-1, cullin-4A, carbonic anhydrase 9, BTB / POZ domain-containing adaptor 3 for CUL3-mediated RhoA degradationMelanoma-associated antigen 10, 26S proteasome non-ATPase regulatory subunit 6, 40S ribosomal protein S26, long-chain fatty acid-CoA ligase 3, N6-adenosine methyltransferase subunit METTL14, ubiquitin-conjugating enzyme E2 H, adenylosuccinate synthetase isoenzyme 2, serine / threonine protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform, actin-binding protein IPP, mitogen-activated protein kinase 4, tyrosine protein phosphatase non-receptor type 23, mitochondrial carrier homolog 1, microspherule protein 1, splicing factor 3B subunit 3, casein kinase I isoform delta, protein kinase A, seipin, CMP-N-acetylneuraminic acid-beta-galactosamide-alpha-2,3-sialyltransferase 2, cleft lip and palate transmembrane protein 1 palate transmembrane protein 1), proteasome subunit beta type 6, RNA-binding protein 42, alpha-enolase, unconventional myosin Ic, THO complex subunit 5 homolog, solute carrier family 35 member B1, sarcoplasmic / endoplasmic reticulum calcium ATPase 1, ATP-dependent RNA helicase DDX50, splicing factor, proline- and glutamine-rich, DDB1- and CUL4-associated factor 11, EH domain-containing protein 1, COP9 signalosome complex subunit 7a, cullin-2, glutathione S-transferase A4, WD repeat ubiquitin-containing protein 19, serine palmitoyltransferase 2, apoptosis-associated speck-like protein containing CARD, DNA damage-induced transcript 3 protein, Erlin-2, DNA polymerase alpha subunit B, thyroid adenoma-associated protein, AP-3 complex subunit delta-1, extended synaptotagmin-2, transportin-1, NudC domain-containing protein 3, ubiquitin carboxyl-terminal hydrolase 35, proline and serine-rich protein 1, Hsp90 co-chaperone Cdc37, ubiquitin-conjugating enzyme E2S, talin-1, kinetochore protein NDC80 homolog,Integrator complex subunit 4, BRISC complex subunit Abro1, filament formation enhancer 1, SET and MYND domain-containing protein 4, leucine-rich PPR motif-containing protein, mitochondria, HAUS augmin-like complex subunit 1, T complex protein 1 subunit zeta, FERM, RhoGEF and pleckstrin domain-containing protein 2, mannose-1-phosphate guanyltransferase alpha, structural maintenance of chromosomes flexible hinge domain-containing protein 1, A-kinase anchor protein 11, tRNA splicing ligase RtcB homolog, sister chromatid cohesion protein PDS5 homolog A A), autophagy-related protein 101, ATP-binding cassette subfamily F member 1, ankyrin repeat and KH domain-containing protein 1, phosphopantothenoylcysteine ​​decarboxylase, bifunctional methylenetetrahydrofolate dehydrogenase / cyclohydrolase, mitochondrial, leucine-rich repeat flightless-interacting protein 2, ADP-ribosylation factor GTPase-activating protein 3, plexin B2, ankyrin repeat and LEM domain-containing protein 2, signal transducer and activator of transcription 5B, DNA-directed RNA polymerase I subunit RPA2, and Son of sevenless homolog 1. 1), formin-like protein 1, cytoskeleton-associated protein 5, DNA dC->dU editing enzyme APOBEC-3F, general transcription factor 3C polypeptide 2, DCC-interacting protein 13 alpha, nucleoside diphosphate kinase 3, dipeptidyl peptidase 8, myotubularin, ubiquitin fusion degradation protein 1 homolog, epidermal growth factor receptor substrate 15-like 1, serine / threonine protein kinase N1, sphingomyelin phosphodiesterase 4, putative dolicholyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, gamma-tubulin complex component 5, bromodomain adjacent to zinc finger domain protein 2A, serine / threonine protein phosphatase 4 regulatory subunit 3A,Protein yippee-like 5, protein TASOR, protein FAM177A1, 60S ribosomal protein L34, TBCC domain-containing protein 1, T complex protein 1 subunit beta, plectin, GDP-mannose 4,6 dehydratase, protein arginine N, -methyltransferase 3, non-conventional myosin-If, TBC1 domain family member 9B, poly[ADP-ribose] polymerase 10, transport and Golgi organization protein 6 homolog, protein transport protein Sec24A, GMP synthase [glutamine hydrolysis], nuclear pore complex protein Nup133, SHC SH2 domain-binding protein 1,3-hydroxyacyl-CoA dehydrogenase type 2, translation initiation factor eIF-2B subunit delta, ubiquitin-related protein 2-like, DNA dC->dU editing enzyme APOBEC-3B, proteasome activator complex subunit 4, cAMP-dependent protein kinase type I-alpha regulatory subunit, 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 4, calcium and integrin-binding protein 1, zinc transporter ZIP6, DDB1 and CUL4-associated factor 15, alpha-ketoglutarate-dependent dioxygenase FTO, serine / threonine protein phosphatase 6 catalytic subunit, U4 / U6 small nuclear ribonucleoprotein Prp3, putative helicase MOV-10, ubiquitin carboxyl-terminal hydrolase 10, CAD protein, importin-4, filamin B, putative helicase with zinc finger domain, Rho GTPase-activating protein 12, proline-rich protein 12, WD repeat-containing protein 70, hexokinase-1, niscalin, protein SPT2 homolog, Bardet-Biedl syndrome 1 protein, ubiquitin-like domain-containing CTD phosphatase 1, programmed cell death protein 5, Na(+) / H(+) exchange regulatory cofactor NHE-RF1, Homs1, tumor necrosis factor receptor superfamily member 10B, glucocorticoid regulatory element-binding protein 1, hydroxyacyl-coenzyme A dehydrogenase, mitochondria, myocyte-specific enhancer factor 2A, zinc finger protein 106, RhoGTPase-activating protein 35, putative RNA-binding protein 23, anamorsin, anaphase-promoting complex subunit 1, intraflagellar transport protein 172 homolog, protein PRRC2B, TRPM8 channel-associated factor 1, DNA damage-binding protein 1, ORM1-like protein 3, WD repeat-containing protein 18, chitinase domain-containing protein 1, protein VPRBP, E3 ubiquitin protein ligase TRIM22, tetratricopeptide repeat protein 17, ninein, golgin subfamily A member 4, multiple C2 and transmembrane domain-containing protein 1, nucleoside diphosphate-binding moiety X motif 19, putative helicase senataxin, foliculin-interacting protein 1, Ras GTPase-activating-like protein IQGAP1, 26S proteasome non-ATPase regulatory subunit 1, F-box only protein 8 8), melanoma inhibitory activity protein 3, IQ domain-containing protein D, phosphate dihydroxyacetone acyltransferase, protein DBF4 homolog A, F-box only protein 25, Hermansky-Pudlak syndrome 5 protein, guanine nucleotide-binding protein subunit beta-5, cytosolic phospholipase A2, 60S acidic ribosomal protein P1, ATP-binding cassette subfamily B member 7, mitochondria, dual specificity mitogen-activated protein kinase kinase 7, Lon protease homolog 2, peroxisome, protein bilizer homolog, histone- Lysine N-methyltransferase SETD1A, endosomal / lysosomal potassium channel TMEM175, serine / threonine protein kinase TAO2, cell division control protein 6 homolog, AT-rich interactive domain-containing protein 4B, transcriptional activator BRG1, ankyrin repeat and SOCS box protein 3, ribonuclease P / MRP protein subunit POP1, translin-related protein X, phosphotriesterase-related protein, methionine adenosyltransferase 2 subunit beta, chromosome transmission fidelity protein 8 homologhomolog), catenin alpha-1, splicing factor 3A subunit 1, aurora kinase B, Vam6 / Vps39-like protein, Kelch-like protein 13, interleukin-6 receptor subunit beta, ankyrin repeat domain-containing protein 17, protein IWS1 homolog, G2 / M phase-specific E3 ubiquitin protein ligase, adenomatous polyposis coli protein (Adenomatous polyposis coli protein) protein), flotillin-2, calpastatin, cyclin-dependent kinase 9, E3 ubiquitin protein ligase listerin, guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1, protein PRR14L, MAP kinase-activated protein kinase 5, Nck-related protein 1, nuclear pore glycoprotein p62, DNA excision repair protein ERCC-6-like, Kelch repeat and BTB domain-containing protein 4, N-acetylneuraminic acid lyase, DENN domain-containing protein 4C, fatty acyl-CoA reductase 2, 28S ribosomal protein S33, mitochondrial, RNA-binding protein 4B, zinc finger protein 143, cAMP response element modulator, WD repeat-containing protein 43, CTD small phosphatase-like protein 2, Ras-related GTP-binding protein C, DNA repair and recombination protein RAD54B, HIV Tat-specific factor 1, negative elongation factor A, Rho-associated protein kinase 1, E3 ISG15-protein ligase HERC5, renal carcinoma differentiation gene 1 protein, E3 ubiquitin-protein ligase UBR4, prolyl 4-hydroxylase subunit alpha-1, archaemetzincin-2, EH domain-binding protein 1, hyaluronan-mediated motility receptor, conserved oligomeric Golgi complex subunit 5, ribosomal L1 domain-containing protein 1, regulator of G protein signaling 10, protein Jade-2, DNA-directed RNA polymerase II subunit RPB3, electron transfer flavoprotein subunit beta, protein Mis18-alpha, phosphatidylinositol 4-kinase beta, cytochrome P45020A1, Ectopic P Granule Protein 5 Homolog, CCAAT / Enhancer-Binding Protein Zeta, MORF4 Family-Related Protein 1-Like 1, Proteasome Subunit Beta Type 2, cAMP-Dependent Protein Kinase Type I Beta Regulatory Subunit, Rap1 GTPase-GDP Dissociation Stimulator 1, Putative E3 Ubiquitin-Protein Ligase HERC4, Protein SON, Proteasome Activator Complex Subunit 2, CCR4-NOT Transcription Complex Subunit 1, DNA Fragmentation Factor Subunit Beta, CREB-Binding Protein, SCAN Domain-Containing Protein 1, Cyclin-Dependent Kinase Inhibitor 1C, ERI1 Exoribonuclease 3, Cyclin-I, Tight Junction Protein ZO-2, DNA-Directed RNA Polymerase II Subunit RPB11-b1 , conserved oligomeric Golgi complex subunit 4, Cip1-interacting zinc finger protein, neufericin, cyclin-dependent kinase 1, RCC1 and BTB domain-containing protein 1, eukaryotic translation initiation factor 3 subunit H, zinc finger SWIM domain-containing protein 1, DNA-directed RNA polymerase II subunit RPB4, Rho guanine nucleotide exchange factor 2, E3 ubiquitin protein ligase TRIM37, DEP domain-containing protein 1A, small nuclear ribonucleoprotein Sm D1, lipopolysaccharide-responsive and beige-like anchor protein, electron transfer flavoprotein subunit alpha, mitochondria, solute carrier family 43 member 3, integrin alpha-4, uridine cytidine kinase-like 1, KH domain-containing, RNA-binding, signal transduction-related protein 1, Rho guanine nucleotide exchange factor 18, steroid receptor RNA activator 1, cytochrome c oxidase subunit 7C, mitochondria, flotillin-1, breast cancer type 1 susceptibility protein, Ral GTPase-activating protein subunit beta, F-box only protein 2222), glycerol-3-phosphate dehydrogenase, mitochondrial, propionyl-CoA carboxylase beta chain, mitochondrial, utrophin, testis-expressed sequence 10 protein, SEC14-like protein 1, ethylmalonyl-CoA decarboxylase, HEAT repeat-containing protein 2, 60S ribosomal protein L6, mitochondrial dynamics protein MID51, zinc finger protein 131, vacuolar protein sorting-associated protein 53 homolog, putative sodium-binding neutral amino acid transporter 10, KN motif and ankyrin repeat domain-containing protein 2, pyridoxal-dependent decarboxylase domain-containing protein 1, pinin, type V proton ATPase subunit H, ubiquitin-conjugating enzyme E2B, inhibitor of nuclear factor kappa B kinase-interacting protein, double-strand break repair protein rad21 homolog, PRA1 family protein 3, DEP domain-containing protein 1B, ATP-binding cassette subfamily B member 10, mitochondrion, SHC converting protein 1, serine / threonine protein phosphatase PP1-gamma catalytic subunit, eukaryotic translation initiation factor 2 subunit 1, anaphase-promoting complex subunit 7, TATA-binding protein-associated factor 172, 2'-5'-oligoadenylate synthase 3, LisH domain-containing protein ARMC9, ankyrin repeat and SOCS box protein 6, DNA polymerase epsilon catalytic subunit A, sestrin-1, type V proton ATPase catalytic subunit A, trinucleotide repeat-containing gene 6A protein Protein quality, TNFAIP3-interacting protein 2, phosphatidylinositol 3-kinase regulatory subunit gamma, TELO2-interacting protein 1 homolog, leucine-rich repeat and coiled-coil domain-containing protein 1, transmembrane emp24 domain-containing protein 9, F-box / LRR repeat protein 5, programmed cell death 6-interacting protein, ribosome production factor 1, exotocin-2, Bloom syndrome protein, U1 small nuclear ribonucleoprotein C, transcription factor RFX3, ubiquitin carboxyl-terminal hydrolase 34, polymerase I and transcript release factor, mediator of RNA polymerase II transcription subunit 12, heterogeneous nuclear ribonucleoprotein C-like 1, serine / threonine protein kinase ATR, neurochondrin, adrenocortical dysplasia protein homolog, RanGTPase-activating protein 1, arfaptin-2, pericentrin, Hermansky-Pudlak syndrome 4 protein, choline / ethanolamine kinase, WD repeat-containing protein 3, peroxisomal membrane protein 4, dynactin subunit 1, AP-3 complex subunit mu-1, arsin, RNA-binding protein 28, zinc finger MYM-type protein 3, RNA polymerase II-associated protein 1, general transcription factor 3C polypeptide 5, EH domain-containing protein 4, huntingtin, Set1 / Ash2 histone methyltransferase complex subunit ASH2, non-POU domain-containing octamer-binding protein, ancient ubiquitous protein 1, coiled-coil domain-containing protein 93, putative ATP-dependent RNA helicase DD X27, nuclear respiratory factor 1, Fanconi anemia group D2 protein, E3 ubiquitin protein ligase UHRF1, cyclic AMP-dependent transcription factor ATF-1, HEAT repeat-containing protein 5B, NmrA-like family domain-containing protein 1, tetratricopeptide repeat protein 21B, inositol 1,4,5-trisphosphate receptor type 1, perilipin-2, V-type proton ATPase subunit C1, protein NOXP20, short-term transient receptor potential channel 1, mitochondrial import receptor subunit TOM22 homolog, AP-3 complex subunit mu-2, phosphorylation Acid dehydrogenase, mitochondria, quinone oxidoreductase, dual specificity protein phosphatase 14, cell division cycle and apoptosis regulator protein 1, protein PAT1 homolog 1, tropomyosin alpha 4 chain, 40S ribosomal protein S15a, prefoldin subunit 4, neurobitisin-like protein 2, E3 ubiquitin protein ligase RNF130, calmodulin-regulated spectrin-related protein 1, HEAT repeat-containing protein 3, carbohydrate sulfotransferase 14, isochorismatase domain-containing protein 1, Rab GTPase-activating protein 1-like, 76 kDa centrosomal protein, exportin-1, von Willebrand factor A domain-containing protein 8, Ras-related protein Rab-5A, MAU2 chromatid cohesion factor homolog, Kelch-like protein 24, protein FAM171B, protein Yippy-like 1, inhibitor of nuclear factor kappa-B kinase subunit alphaalpha), putative ATP-dependent RNA helicase DDX56, uncharacterized protein C18orf8, protein LLP homolog, AP-2 complex subunit sigma, maestro fever-like repeat-containing protein family member 1, nucleolar protein 9, high mobility group protein 20A, HLA class II histocompatibility antigen, DR beta 3 chain, importin-9, protein asunder homolog, ribonuclease UK114, zinc finger BED domain-containing protein 1, tyrosine protein kinase JAK1, putative RNA-binding protein 15, AKT-interacting protein, Werner syndrome ATP-dependent helicase, protein downstream neighbor of Son Son), protein Artemis, adenosylhomocysteinase 2, ligand-dependent nuclear receptor interactor 1, Kelch-like protein 8, adenosylhomocysteinase, DNA-directed RNA polymerase I, II, and III subunit RPABC3, transcription factor 25, nuclear export protein nudC, COP9 signalosome complex subunit 1, nuclear protein TPR, neutral alpha-glucosidase C, UPF0585 protein C16orf13, BTB / POZ domain-containing protein KCTD3, DBF4-type zinc finger-containing protein 2, NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondria, protein unc-50 homolog, vacuolar membrane protein 1, S UMO-activating enzyme subunit 2, mitotic checkpoint serine / threonine protein kinase BUB1 beta, EKC / KEOPS complex subunit TPRKB, PRKC apoptosis WT1 regulatory protein, putative methyltransferase TARBP1, E3 ubiquitin protein ligase HUWE1, 26S proteasome non-ATPase regulatory subunit 8, leucine tRNA ligase, cytoplasm, striatin-interacting protein 2, zinc finger protein Pegasus, A-kinase anchor protein 10, mitochondrion, RNA polymerase II subunit AC-terminal domain phosphatase, DNA repair protein complementing XP-Gcells), protein phosphatase 1G, interleukin-1 receptor-associated kinase-like 2, dual specificity protein kinase CLK2, sterol regulatory element-binding protein 2, actin-related protein 2 / 3 complex subunit 4, replication factor C subunit 5, histone deacetylase 3, 40S ribosomal protein S10, protein unc-93 homolog B1, sodium- and chloride-dependent taurine transporter, cullin-7, kinetochore-associated protein 1, histone deacetylase 1, syntaxin-binding protein 5, speriolin-like protein, erythroid differentiation-related factor 1, ubiquitin-conjugating enzyme E2 J2, E3 ubiquitin protein ligase Hakai, annexin A5, cAMP-dependent protein kinase catalytic subunit alpha, cytochrome c, COMM domain-containing protein 2, Akirin-1, ORM1-like protein 1, sodium channel and clathrin linker 1, tetratricopeptide repeat protein 14, structural maintenance of chromosomes protein 4, BCL-6 corepressor, NEDD8-activating enzyme E1 regulatory subunit, RANBP2-like and GRIP domain-containing protein 2, mediator of RNA polymerase II transcription subunit 19, Afadin, tubulin beta 2A chain, N-alpha-acetyltransferase 50, origin recognition complex subunit 1, syntaxin-binding protein 2, Abl interactor 1, FERM domain-containing protein 4A, 60S ribosomal subunit biogenesis protein NIP7 homolog, dolichol phosphate mannosyltransferase subunit 3, Protein enabled homolog homolog, F-actin capping protein subunit beta, centromere protein W, histone H1.1, crooked neck-like protein 1, exportin T, chondroitin sulfate glucuronyltransferase, 78 kDa glucose-regulated protein, X-ray repair cross-complementing protein 66), WD and tetratricopeptide repeat protein 1, DNA replication licensing factor MCM3, retinoblastoma-like protein 1, alpha-2-macroglobulin receptor-associated protein, immunoglobulin-binding protein 1, myeloid leukemia factor 2, histone lysine N-methyltransferase NSD3, cecernin-1, DNA dC->dU editing enzyme APOBEC-3D, syntaxin-18, WD repeat-containing protein 91, tubulin-specific chaperone A, MAP3K12 binding inhibitor protein 1, spectrin alpha chain, non-erythroid 1, transcription factor ATRX, nuclear receptor corepressor 1, protein kinase C delta type, ATP-dependent RNA helicase DDX42, E3 ubiquitin protein ligase TTC3, and part of the RAB6A-GEF complex Inner protein 1, B cell receptor-associated protein 31, poly(A)-specific ribonuclease PARN, translation initiation factor eIF-2B subunit epsilon, RNA-binding protein 8A, pre-mRNA processing factor 6, cleavage and polyadenylation specificity factor subunit 7, 39S ribosomal protein L20, mitochondria, melanoma-associated antigen F1, lysine-specific demethylase 2B, translation factor GUF1, mitochondria, V-type proton ATPase subunit E1, 60S ribosomal protein L9, actin-related protein 2 / 3 complex subunit 5, prefoldin subunit 6, serine hydroxymethyltransferase, mitochondria, interferon alpha-inducible protein 6, phagocytosis and cell motility protein 2 (Engulfment and cell motility protein 2, transcription initiation factor IIE subunit beta, F-box only protein 21, cytochrome c oxidase subunit 7A-related protein, mitochondria, mitochondrial ubiquitin ligase activator of NFKB 1, NAD(P)H dehydrogenase [quinone] 1, lysine-specific demethylase 5D, major facilitator superfamily domain-containing protein 1212), casein kinase II subunit beta, Sec1 family domain-containing protein 1, receptor expression-enhancing protein 3, kinetochore protein Nuf2, E3 ubiquitin protein ligase macolin-1, putative ATP-dependent RNA helicase DHX37, exosome complex component RRP41, angiogenesis-associated migratory cell protein (Angio-associated migratory cell protein), trans-3-hydroxy-L-proline dehydratase, helicase with zinc finger domain 2, Fanconi anemia group I protein, pescadillo homolog, nucleolus and spindle-associated protein 1, retinoblastoma-associated protein, DNA repair protein XRCC2, Derlin-1, DNA (cytosine-5)-methyltransferase 3A, putative rhophilin-2-like protein RHPN2P1, TRAF2 and NCK-interacting protein kinase, nucleoside diphosphate kinase 6, methylsterol monooxygenase 1, protein HIRA, putative phospholipid transport ATPase IF, integrator complex subunit Unit 12, signal peptidase complex catalytic subunit SEC11C, sororin, histone H2B type 1-K, integrator complex subunit 8, Toll-interacting protein, amyloid protein-binding protein 2, 182 kDa tankyrase 1-binding protein, cytoplasmic FMR1-interacting protein 2, heat shock protein 105 kDa, chromodomain-helicase-DNA-binding protein 2, 26S protease regulatory subunit 10B, zinc finger MYND domain-containing protein 11, general transcription factor IIH subunit 5, ubiquitin carboxyl-terminal hydrolase 19, Serrate RNA effector molecule homolog, RasGTPase-activating protein-binding protein 2, heat shock 70 kDa protein 4, coatomer subunit beta, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, DDB1 and CUL4-associated factor 10, negative elongation factor E, coiled-coil domain-containing protein 66, E3 ubiquitin protein ligase MGRN1, WD repeat-containing protein 36, nonconventional myosin Ie, PH domain leucine-rich repeat-containing protein phosphatase 1, paxillin, kinesin-like protein KIF21A, 2',3'-cyclic nucleotide 3'-phosphodiesterase, protein FAM192A, proteasome subunit beta type 4, sorting nexin-14, Krueger Pell-like factor 6, tropomodulin-3, nuclear receptor-binding protein, nitrogen permease regulator 2-like protein, OTU domain-containing protein 5, histone-binding protein RBBP4, sorting nexin-24, poly(rC)-binding protein 2, vacuolar fusion protein CCZ1 homolog, ATP-dependent RNA helicase DDX19B, elongation factor 1-gamma, adenylate cyclase type 3, MICOS complex subunit MIC19, ferritin light chain, glutaredoxin-3, pre-B cell leukemia transcription factor 3, AP-2 complex subunit alpha-1, 40S ribosomal protein S24, enhancer of mRNA decapping protein 3, neuroblastoma amplified sequence, protein phosphatase 1 regulatory subunit 7, exosome component 10, cyclin-dependent kinase 14, translocation protein SEC62, constitutive coactivator of peroxisome proliferator-activated receptor gamma, protein SCAF11, Rho GTPase-activating protein 21, alphaaptin-1, AP-2 complex subunit mu, ubiquitin carboxyl-terminal hydrolase 36, glutathione S-transferase kappa 1, Kelch repeat and BTB domain-containing protein 7, calcium homeostasis endoplasmic reticulum protein, RNA polymerase II-associated protein 3, zinc finger E-box-binding homeobox 1, dynein light chain 1, cytoplasm, 39S ribosomal protein L2, mitochondria, figetin-like protein 1 1), WD repeat-containing protein 46, exosome complex component RRP40, ubiquinol-cytochrome c reductase complex assembly factor 1, antizyme inhibitor 1, transketolase, carbohydrate sulfotransferase 10, LanC-like protein 1, histone H2A.V, E3 ubiquitin protein ligase TRIP12, non-conventional myosin VI, integrin-linked protein kinase, serine / threonine protein kinase WNK1, centromere protein M, ankyrin repeat family A protein 2, and small elongation complex subunit 1. 1), deoxynucleoside triphosphate triphosphohydrolase SAMHD1, lanosterol 14-alpha demethylase, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4, TFIIH basal transcription factor complex helicase XPD subunit, thymidine kinase, cytosol, peroxiredoxin-6, LYR motif-containing protein 1, SWI / SNF complex subunit SMARCC2, lysine-specific histone demethylase 1B, induced myeloid leukemia cell differentiation protein Mcl-1, V-type proton ATPase 16kDa proteolipid subunit, HLA class II histocompatibility antigen, DP alpha 1 chain, ATP synthase subunit g, mitochondria, interferon regulatory factor 9, cleavage and polyadenylation specificity factor subunit 2Centrin-specific protease 6, zinc finger CCCH domain-containing protein 4, squalene monooxygenase, RNA cytidine acetyltransferase, ribonuclease inhibitor, UDP-glucose:glycoprotein glucosyltransferase 2, bifunctional apoptosis regulator, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1, zinc finger protein 302, phosphatidylinositol 4-phosphate 5-kinase type 1 alpha, transmembrane emp24 domain-containing protein 10, phosphatidylinositol-binding clathrin assembly protein, DnaJ homolog subfamily B member 14, ezrin, moesin, transcription elongation factor B polypeptide 2, small kinetochore-associated protein protein), RANBP2-like and GRIP domain-containing protein 1, mitochondrial fission 1 protein, spliceosomal RNA helicase DDX39B, activating signal cointegrator 1 complex subunit 2, fibroblast growth factor receptor 1, 60S ribosomal protein L7-like 1, tyrosine protein kinase JAK2, replication factor C subunit 2, SAGA-associated factor 29, B-cell linker protein, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, Myc proto-oncogene protein, translationally controlled oncoprotein, baculovirus IAP repeat-containing protein 2, serine / threonine protein kinase Chk1, 40S ribosomal protein S9, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, BRISC and BRCA1-A complex member 1, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3, tyrosine tRNA ligase, cytoplasmic, target of rapamycin complex 2 subunit MAPKAP1, activator of 90 kDa heat shock protein ATPase homolog 1, class E basic helix-loop-helix protein 40, 60S ribosomal protein L27a, cilium- and flagella-associated protein 20, polyribonucleotide 5'-hydroxyl kinase Clp1,Elongator complex protein 3, nodal modulator 2, low-density lipoprotein receptor adaptor protein 1, protein FAM136A, selenoprotein T, cAMP-dependent protein kinase catalytic subunit beta, small EDRK-rich factor 2, A-kinase anchor protein 13, renin receptor, chromosome alignment retention phosphoprotein 1, mediator of RNA polymerase II transcription subunit 27, zinc finger and BTB domain-containing protein 40, protein FAM3C, pseudouridylate synthase 7 homolog, sa Iclin-dependent kinase 11A, cyclin-dependent kinase 11B, zinc finger FYVE domain-containing protein 16, cyclic AMP-dependent transcription factor ATF-6 beta, bridging integrator 3, 26S proteasome non-ATPase regulatory subunit 11, RNA-binding protein 43, serine / threonine protein kinase Chk2, 60S ribosomal protein L13a, G2 / mitosis-specific cyclin B2, tryptophan-tRNA ligase, mitochondria, B lymphocyte antigen CD19, astrotactin-2, Rab GDP dissociation inhibitor beta, non-conventional myosin-Id, Nipped-B-like protein, E3 ubiquitin-protein ligase RAD18, motile sperm domain-containing protein 2, microtubule-associated protein RP / EB family member 1, DNA replication licensing factor MCM2, methionine synthase reductase, leucine-rich repeat-containing protein 58, proteasome assembly chaperone 2, neurogidin, 40S ribosomal protein S7, PRELI domain-containing protein 3B, cyclin-T1, dolicholyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit, large proline-rich protein BAG6, myosin-7B, DnaJ homolog subfamily B member 5, nuclear factor interleukin-3 regulatory protein, Ras-related protein Rab-7a, fiji-related protein homolog, CUGBP Elav-like family member 2, serine / threonine protein kinase PAK2, serine / threonine / tyrosine-interacting-like protein 1, monocarboxylate transporter 7, oxysterol-binding protein-related protein 9,DnaJ homolog subfamily A member 1, copine 8, forkhead box protein K2, RNA polymerase II subunit AC-terminal domain phosphatase SSU72, alpha-galactosidase A, Mis18-binding protein 1, desmin, DNA-(purinic or apyrimidinic site) lyase, tRNA (cytosine(34)-C(5))-methyltransferase, condensin-2 complex subunit H2, protein C10, TRAF3-interacting JNK activation modulator, eukaryotic translation initiation factor 3 subunit E TCF3 fusion partner, inorganic pyrophosphatase, LBH domain-containing protein 1, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondria, ubiquilin-2, gammataxin, di-N-acetylcytobiase, sorting nexin-17, Ras-related GTP-binding protein A, tropomyosin alpha-3 chain, tetratricopeptide repeat protein 39C, aurora kinase A, histone H2B type 2-E, sorbitol dehydrogenase, serine / threonine protein kinase N ek6, U3 small nuclear ribonucleoprotein protein MPP10, 60S ribosomal protein L31, importin-8, replication factor C subunit 4, putative polycomb group protein ASXL1, protein PML, DNA-directed RNA polymerase I, II, and III subunit RPABC2, translational activator GCN1, zinc finger protein 195, fragile X mental retardation syndrome-associated protein 1, dual specificity tyrosine phosphorylation-regulated kinase 1A, integrator complex subunit 1, RNA pseudouridylate synthase domain-containing Protein 4, phosducin-like protein 3, Golgi phosphoprotein 3, guanine nucleotide-binding protein G(I) / G(S) / G(O) subunit gamma-5, cartilage-related protein, ubiquitin-associated domain-containing protein 2, heterogeneous nuclear ribonucleoprotein Q, semaphorin-7A, pentatricopeptide repeat domain-containing protein 3, mitochondria, Egl9 homolog 2, Parkinson's disease 7 domain-containing protein 1, nuclear pore complex proteins Nup98-Nup96, glycogen synthase kinase-3 beta,BTB / POZ domain-containing protein KCTD20, tubulin gamma-1 chain, LYR motif-containing protein 2, NF-kappa-B inhibitor beta, kinesin-like protein KIF18B, histone deacetylase 5, HCLS1-related protein X-1, 40S ribosomal protein S4, X isoform, E3 ubiquitin protein ligase MARCH6, Kelch-like protein 20, terminal uridyl transferase 4, TNF receptor-associated factor 1, DnaJ homolog subfamily B member 12, E3 ubiquitin protein ligase UBR5, DNA Methyltransferase 1-associated protein 1, zinc finger MIZ domain-containing protein 1, inhibitor of apoptosis 5, 39S ribosomal protein L55, mitochondrial, phosphate carrier protein, mitochondrial, formin-binding protein 1, F-box-only protein 33, protein-lysine N-methyltransferase EEF2KMT, growth factor receptor-binding protein 2, 60S ribosomal protein L23, neuroepithelial cell transforming gene 1 protein, isoleucine-tRNA ligase, cytoplasmic, uncharacterized protein KIAA155 1, 60S ribosomal protein L30, protein BRICK1, protein PRRC2C, cytoskeleton-associated protein 2-like, cyclin-dependent kinase 12, cold shock domain-containing protein E1, eukaryotic translation initiation factor 4H, cell division cycle 5-like protein, biogenesis of lysosome-related organelle complex 1 subunit 1, beta-catenin-like protein 1, 60S ribosomal protein L37a, peroxisomal multifunctional enzyme type 2, ubiquitin 40S ribosomal protein S27a, RAD50-interacting protein 1, dynamin-binding protein Protein, diphosphoinositol polyphosphate phosphohydrolase 1, diphosphoinositol polyphosphate phosphohydrolase 2, coatomer subunit beta', plakophilin-4, tRNA pseudouridine synthase-like 1, protein ERGIC-53, F-box-only protein 3, ATP synthase mitochondrial F1 complex assembly factor 1, tRNA (guanine(26)-N(2))-dimethyltransferase, poly[ADP-ribose] polymerase 3, drebrin-like protein, YEATS domain-containing protein 4,Sorting nexin-3, copper transport protein ATOX1, U3 small nucleolar RNA-associated protein 14 homolog A, acetolactate synthase-like protein, inosine-5'-monophosphate dehydrogenase 2, transmembrane protein 107, mitochondrial import receptor subunit TOM5 homolog, ribosome biogenesis protein WDR12, WD repeat-containing protein 74, 104 kDa centrosome, Proteins include putative E3 ubiquitin protein ligase TRIM8, UPF0769 protein C21orf59, E3 ubiquitin protein ligase Itchy homolog, ubiquilin-1, ferritin heavy chain, single-stranded DNA binding protein 2, PERQ amino acid-rich containing GYF domain-containing protein 2, transcription adaptor 1, zinc finger protein 296, UV-stimulated scaffold protein A, WD repeat-containing protein 63, programmed cell death protein 6, WD repeat-containing protein 62, beta-parvin, and DnaJ homolog subfamily. LiA member 2, protein sel-1 homolog 1, HLA class II histocompatibility antigen, DRB1-11 beta chain, retinoic acid receptor alpha, vacuolar protein sorting-associated protein 51 homolog, Misshapen-like kinase 1, arginine-glutamic acid dipeptide repeat protein, manganese transport ATPase 13A1, myotubularin-related protein 10, double-stranded RNA-specific adenosine deaminase, adenylate cyclase type 6, cytochrome c oxidase subunit 6C, N-alpha-acetyltransferase transferase 30, COP9 signalosome complex subunit 2, cell division cycle-related protein 2, zinc finger protein 697, telomere protection protein 1, uridine diphosphate glucose pyrophosphatase, ubiquitin carboxyl-terminal hydrolase 48, RNA-binding protein EWS, immediate early response gene 5 protein, PCI domain-containing protein 2, MAP7 domain-containing protein 1, 60S ribosomal protein L18, WD repeat and coiled-coil-containing protein C2orf44, canadaptin, double-stranded RNA binding Protein Stauffen homolog 2, F-box only protein 11, E3 ubiquitin protein ligase CHFR, heterogeneous nuclear ribonucleoprotein U-like protein 2, cathepsin Z, MOB kinase activator 1A, lysine-specific demethylase 5C, lysine-specific demethylase 5A, putative cation-transporting ATPase 13A4, centrin-specific protease 5, SRR1-like protein, epidermal growth factor receptor kinase substrate 8, cytoplasmic dynein 1 light intermediate chain 1, zinc finger protein 619, fatty acyl-CoA reductase 1, NHP2-like protein 1,RNA-binding protein 27, RNA-binding protein 26, geranylgeranyl pyrophosphate synthase, myosin phosphatase Rho-interacting protein, protein kinase C delta-binding protein, histidine triad nucleotide-binding protein 1, interferon-related developmental regulator 1, GPI mannosyltransferase 3, ubiquitin-like protein 7, exportin-6, male-specific lethal 3 homolog, flap endonuclease 1, elongation factor 1 alpha 1, COP9 signalosome complex subunit 3, HIG1 domain family Member 2A, mitochondrial, 3-phosphoinositide-dependent protein kinase 1, sodium-binding neutral amino acid transporter 2, intraflagellar transport protein 81 homolog, cleavage and polyadenylation specificity factor subunit 3, 57 kDa centrosomal protein, interferon-stimulated gene 20 kDa protein, DNA-directed RNA polymerase II subunit RPB2, protein kintoun, leucine-rich repeat-containing protein 20, putative 18S rRNA (guanine-N(7))-methyltransferase, heterogeneous nuclear ribonucleoprotein Protein A3, transmembrane protein 263, glutathione S-transferase P, adenylosuccinate lyase, ER membrane protein complex subunit 1, JmjC domain-containing protein 8, AN1-type zinc finger protein 5, cullin-3, MICOS complex subunit MIC27, selenoprotein H, centromeric protein H, beta-hexosaminidase subunit alpha, zinc phosphodiesterase ELAC protein 2, BRCA1-A complex subunit BRE, SRSF protein kinase 1, insulin-like growth factor 2 mRNA binding protein 2, coiled-coil domain-containing protein 85B, 55 kDa centrosomal protein, COMM domain-containing protein 4, 14-3-3 protein theta, armadillo repeat-containing X-linked protein 3, uncharacterized protein C6orf226, DNA-directed RNA polymerase I subunit RPA1, syntaxin binding protein 1, small nuclear ribonucleoprotein SmD2, T-complex protein 1 subunit delta, nucleophosmin, serine / arginine repeat matrix protein 2, PC4 and SFRS1 interacting protein;Naridilisin (N-arginine dibasic convertase), isoform CRA_d, Ragulator complex protein LAMTOR4, golgin subfamily B member 1, E3 SUMO protein ligase PIAS3, prohibitin, maspardin, chromodomain-helicase-DNA-binding protein 6, V-type proton ATPase subunit D, tapelin, coronin-1C, importin subunit alpha-4, pre-mRNA processing factor 19, single-stranded DNA-binding protein, mitochondria, vacuolar protein sorting-associated protein 33A, STAGA complex 65 subunit gamma, F-box-only protein 38, protein C-ets-1, DNA repair endonuclease XPF, clathrin light chain A, inhibitor of growth protein 4, protein zer-1 homolog, apolipoprotein L2, serine / arginine-associated protein 53, transcription initiation factor IIB, Ras suppressor protein 1, V-type proton ATPase 116 kDa subunit a isoform 1, scavenger receptor class B member 1, importin-11, periodic tryptophan protein 1 homolog, sequestosome-1, DNA replication licensing factor MCM6, lupus La protein, 40S ribosomal protein S2, DNA-directed RNA polymerase I, II, and III subunit RPABC4, dual specificity protein kinase CLK3, mitochondrial import inner membrane translocase subunit TIM50, cyclin-dependent kinase 7, interleukin enhancer-binding factor 3, poly(U)-binding splicing factor PUF60, Fc receptor-like A, heterogeneous nuclear ribonucleoprotein H, nucleolar complex protein 2 homolog, DNA topoisomerase 1, and true Eukaryotic initiation factor 4A-II, inner kinetochore protein, ZW10 interactor, epsilon sarcoglycan, protein disulfide isomerase A6, transcription factor E2F7, GDP-L-fucose synthase, runt-related transcription factor 3, chromodomain helicase DNA-binding protein 4, SRA stem-loop interacting RNA-binding protein, mitochondria, poly[ADP-ribose] polymerase 9, zinc finger protein 451, coatomer subunit zeta-1, eukaryotic translation initiation factor 4B,Death-associated protein kinase 3, leucine-rich repeat-containing protein 47, guanylate-binding protein 1, actin-related protein 2 / 3 complex subunit 1B, proteasome maturation protein, putative ATP-dependent RNA helicase DDX41, general vesicle transport factor p115, SH2 domain-containing protein 3C, polyadenylate-binding protein-interacting protein 1, histone H3.1, putative ATP-dependent RNA helicase DDX6, poly(rC)-binding protein 1, steroid hormone receptor ERR1, cytoskeleton-associated protein 4, integrin beta-7, eukaryotic translation initiation factor 3 subunit A, F-box-only protein 7, GPN-loop GTPase 2, melanoma-associated antigen 12, basic leucine zipper and W 2 domain-containing protein 2, stomatin-like protein 3, condensin complex subunit 1, septin-11, glutamine-dependent NAD(+) synthetase, mitogen-activated protein kinase kinase kinase 5, ubiquitin-like modifier activating enzyme 1, Disco-interacting protein 2 homolog B, HLA class I histocompatibility antigen, A-24 alpha chain, integrator complex subunit 2, UPF0428 protein CXorf56, MMS19 nucleotide excision repair protein homolog, AF4 / FMR2 family member 4, Ras-related C3 botulinum toxin substrate 1, bone morphogenetic protein receptor type 1B, multiple epidermal growth factor-like domain protein 8, keratin, type II cytoskeleton 1, tumor suppressor candidate 3, Rho GTPase-activating protein 24, nuclear nucleic acid-binding protein C1D, Pecanex-like protein 1, melanoma antigen preferentially expressed in tumors, RNA exonuclease 4, YTH domain-containing family protein 2, putative bifunctional methylenetetrahydrofolate dehydrogenase / cyclohydrolase 2, HLA class I histocompatibility antigen, A-29 alpha chain, ubiquitin-like protein ISG15, N-acetyltransferase 8, protein prune homolog 2, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, glutathione peroxidase 1, dermokine, PRELI domain-containing protein 1, mitochondria, putative WAS protein family homolog 3Mitochondrial import inner membrane translocase subunit Tim23, SLAM family member 6, putative ubiquitin carboxyl-terminal hydrolase FAF-Y, annexin A3, microtubule-associated protein 1B, glyoxylate reductase / hydroxypyruvate reductase, 40S ribosomal protein S4, Y isoform 1, putative ATP-dependent RNA helicase DDX4, EH domain-containing protein 2, ubiquitin carboxyl-terminal hydrolase 45, trinucleotide repeat-containing gene 18 protein, aldo-ketoreductase family 1 member C1, protein phosphatase 1 regulatory subunit 35, Frizzled-2, E3 ubiquitin protein ligase HECTD1, V-type proton ATPase subunit S1, peroxisomal membrane protein PEX16, pro-interleukin-16, amidophosphoribosyltransferase, Hsc70-interacting protein, YEATS domain-containing protein 2, protein A arginine N-methyltransferase 1, cyclic AMP response element binding protein 3-like protein 2, solute carrier family 25 member 46, general transcription factor II-I, 40S ribosomal protein S30, 2'-5'-oligoadenylate synthase 1, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1, reticulocalvin 1, S-adenosylmethionine synthase isoform type 1, membranalin, dynamin-like 120 kDa protein, mitochondrion, growth hormone-inducible transmembrane protein, heat shock-associated 70 kDa protein 2, eukaryotic translation initiation factor 3 subunit B, Ras-specific guanine nucleotide-releasing factor 1, voltage-dependent anion-selective channel protein 2, protein unc-13 homolog D, Golgi apparatus protein 1, eukaryotic translation initiation factor 6, putative ribonuclease ZC3H12D, lagulator complex protein LAMTOR1, ribonucleoside diphosphate reductase subunit M2 B, zinc finger protein 638, B and T lymphocyte attenuator, CD44 antigen, Cordon-bleu protein-like 1, CC chemokine receptor type 7, lagulator complex protein LAMTOR3,IgG receptor FcRn large subunit p51, serine / threonine protein kinase LATS1, E3 ubiquitin protein ligase CHIP, T cell activation Rho GTPase-activating protein, platelet endothelial cell adhesion molecule, TBC1 domain family member 22A, endoplasmic reticulum resident protein 44, lipolysis-stimulating protein, Protein receptor, glucose-6-phosphate isomerase, cystatin C, Ras-related protein Rab-11A, cadherin EGF LAG seven-pass G-type receptor 1, tumor protein p53-inducible protein 11, short-chain dehydrogenase / reductase 3, putative ribosome biogenesis protein RLP24, ceruloplasmin, ceramide glucosyltransferase, dystrophin, uncharacterized protein CXorf21, MyoD family inhibitor domain-containing protein, and obscurin-like protein 1 1), beta 1,4-galactosyltransferase 1, plasma membrane calcium transporting ATPase 1, vesicle-associated membrane protein 3, protein CDV3 homolog, peroxiredoxin-1, methyltransferase-like protein 7A, HLA class II histocompatibility antigen, DO beta chain, receptor tyrosine-protein phosphatase alpha, ATP-binding cassette subfamily A member 6, 14-3-3 protein beta / alpha, glycosyltransferase 8 domain-containing protein 1, serine incorporator 3, NACHT, LRR and PYD domain-containing protein 2, bakki Human IAP repeat-containing protein 5, alpha-mannosidase 2, DnaJ homolog subfamily C member 5, Fas inhibitor of apoptosis molecule 3, HLA class II histocompatibility antigen, DM alpha chain, heterogeneous nuclear ribonucleoprotein A1-like 2, transcriptional regulatory protein BACH2, zinc finger protein 107, putative ATP-dependent RNA helicase DDX46, kynureninase, interleukin-4 receptor subunit alpha, polypeptide N-acetylgalactosaminyltransferase 1, fibromodulin, pericentriolar material 1 protein, 60S ribosomal protein L3, glycosylphosphatidylinositol anchor attachment 1 protein, AT-rich interactive domain-containing protein 5B, carbohydrate sulfotransferase 2, Kelch-like ECH-associated protein 1, DmX-like protein 1, 14-3-3 protein zeta / delta, plexin B3,Elongation factor Tu, mitochondria, protocadherin-9, monoglyceride lipase, afadin and alpha-actinin binding protein, platelet glycoprotein 4, transmembrane protein C16orf54, cullin-related NEDD8 dissociating protein 1, proline and serine-rich protein 2, procathepsin H, RUN and FYVE domain-containing protein 1, neurofibromin, leukosialin, arrestin domain-containing protein 4, TP53 target gene 5 protein, vitamin D binding protein, tumor necrosis factor receptor superfamily member 13C, phosphate-regulated neutral endopeptidase, interleukin-1 beta, interleukin-17 receptor A, putative heat shock 70 kDa protein 7, cytochrome b ascorbate-dependent protein 3, vesicle-associated membrane protein 1, Ras GTPase-activating protein nGAP, BRCA2 and CDKN1A interacting protein, Rab GTPase-activating protein 1, melanoma-associated antigen C2, CC motif chemokine 3, Ig gamma-1 chain C region, serum albumin, basement membrane-specific heparan sulfate proteoglycan core protein, protein phosphatase 1M, guanine nucleotide-binding protein G(I) / G(S) / G(T) subunit beta-1, HLA class I histocompatibility antigen, A-23 alpha chain, zinc finger protein ZPR1, cytochrome c oxidase assembly factor 3 homolog, mitochondria, Rho-GAP domain, Arf-GAP with ANK repeat and PH domain-containing protein 1, keratin, type I cytoskeleton 9, anion exchange protein Protein 2, tumor susceptibility gene 101 protein, A-kinase anchor protein 1, mitochondria, 4-hydroxyphenylpyruvate dioxygenase-like protein, nucleosome remodeling factor subunit BPTF, centrin-3, uridine cytidine kinase 2, isovaleryl-CoA dehydrogenase, mitochondria, alkyldihydroxyacetonephosphate synthase, peroxisome, polyadenylate binding protein 4, polyadenylate binding protein 3, bromodomain adjacent to zinc finger domain protein 2B, protein unc-45 homolog A, iron-sulfur cluster assembly 2 homolog, mitochondria,ATP-dependent RNA helicase DHX36, multidrug resistance protein 1, WD repeat-containing protein 11, serine-rich coiled-coil domain-containing protein 2, protein KRI1 homolog, 192 kDa centrosomal protein, zinc finger protein 829, protein kinase C-binding protein 1, AT-rich interactive domain-containing protein 1A, Msx2-interacting protein, long-chain fatty acid CoA ligase 1, intercellular adhesion molecule 3, molasses protein, cytochrome c oxidase subunit 7A2, mitochondrial A, HLA class I histocompatibility antigen, Cw-5 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, dihydropyrimidinase-related protein 2, deoxyuridine 5'-triphosphate nucleotidyl hydrolase, mitochondrion, translocon-associated protein subunit alpha, endoplasmic reticulum resident protein 29, lysosomal alpha glucosidase, armadillo repeat-containing protein 8, pre-rRNA processing protein TSR1 homolog, protein FAM98B, 40S ribosomal protein S28, Rab GDP dissociation inhibitor alpha, lysosome-associated membrane glycoprotein 2, menin, uncharacterized protein C1orf131, protein MON2 homolog, major facilitator superfamily domain-containing protein 10, protein CNPPD1, E3 ubiquitin protein ligase MYCBP2, NEDD4 family interacting protein 1, inositol hexakisphosphate kinase 2, translocon-associated protein subunit delta, cleavage and polyadenylation specificity factor subunit 5, zinc finger protein 2 81, calpain-1 catalytic subunit, copine-1, ornithine decarboxylase antizyme 1, ER degradation-promoting alpha-mannosidase-like protein 1, nuclear membrane integral protein 1, ER membrane protein complex subunit 4, 60S ribosomal protein L17, charged multivesicular body protein 2a, pre-mRNA cleavage complex 2 protein Pcf11, myosin-7, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondria, protein diaphanous homolog 3, cytochrome b-c1 complex subunit 8,Intron-binding protein Aquarius, serine / threonine protein kinase 38, 39S ribosomal protein L43, mitochondria, protein Diaphanus homolog 1, 60S ribosomal protein L37, vacuolar protein sorting-associated protein 4A, COMM domain-containing protein 3, POTE ankyrin domain family E, TAR DNA-binding protein 43, hemoglobin subunit delta, ubiquitin-conjugating enzyme E2 D2, CDK5 regulatory subunit-associated protein 1, nuclear export mediator factor NEMF, late secretory pathway protein AVL9 homolog, elongation factor 1-beta, poly(A) RNA polymerase GLD2, small elongation complex subunit 2, regulator of apoptosis 1, zinc finger protein 24, G1 / S-specific cyclin E2, signal peptidase complex subunit 1, Lon protease homolog, mitochondrial, deoxynucleotidyl transferase terminal interacting protein 1, retinoblastoma-like protein 2, cullin-4B, DDB1 and CUL4-associated factor 8, zyxin, protein SDA1 homolog, muscleblind-like protein 3, U6 snRNA-associated Sm-like protein LSm7, RuvB-like 1, calcium-binding protein 39-like, small subunit processome component 20 homolog, mitochondrial processing peptidase subunit alpha, DNA ligase 1, gamma-aminobutyric acid receptor-associated protein-like 1, translocation chain-associated membrane protein 1, NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, heme oxygenase 2, WD repeat-containing protein 35, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12, nuclear factor erythroid 2-related factor 3, Rho GTPase-activating protein 1, tubulin alpha-1C chain, sorting nexin-4, CWF19-like protein 1, methionine tRNA ligase, cytoplasmic, nuclease-sensitive element-binding protein 1, pre-mRNA 3'-end processing protein WDR33, fatty acid desaturase 2, Surfeit locus protein 4 4), protein BIVM-ERCC5, interferon-induced helicase C domain-containing protein 1, suppressor of fusion homolog;Astrocytic phosphoprotein PEA-15 PEA-15), protein ELYS, solute carrier family 23 member 2, splicing factor 3B subunit 5, protein kinase from lymphokine-activated killer T cells, signal transducer and activator of transcription 2, zinc finger protein 280C, peroxisomal acyl-coenzyme A oxidase 3, oxidative stress-induced growth inhibitor 2, iron-responsive element-binding protein 2, StAR-related lipid transfer protein 7, mitochondrial, F-actin capping protein subunit alpha-2, mitochondrial folate transporter / carrier, protein lysine N-methyltransferase METTL10, cytochrome c oxidase subunit 4 isoform 1, mitochondrial, guanine nucleotide-binding protein-like 3-like protein, Rho-associated BTB domain-containing protein 1, pre-mRNA splicing factor SPF27, serine / arginine-rich splicing factor 1, ribosome biogenesis protein BMS1 homolog, BRCA1-related protein, lipopolysaccharide-induced tumor necrosis factor alpha, TraB domain-containing protein, ho Sphatidylinositol 4-kinase alpha, microsomal glutathione S-transferase 3, prolyl endopeptidase, vacuolar protein sorting-associated protein 41 homolog, GTPase-activating protein and VPS9 domain-containing protein 1, 26S proteasome non-ATPase regulatory subunit 4, protein SDE2 homolog, ADP-ribosylation factor 5, regulation of nuclear pre-mRNA domain-containing protein 2, ADP / ATP translocase 3, 60S ribosomal protein L36, myotrophin, Protein PRRC2A, NSFL1 cofactor p47, interferon regulatory factor 2-binding protein 1, serine / threonine protein kinase 4, S-formyl glutathione hydrolase, E3 ubiquitin / ISG15 ligase TRIM25, omega amidase NIT2, COP9 signalosome complex subunit 8, asparagine-tRNA ligase, cytoplasmic, glucose-6-phosphate 1-dehydrogenase, transgelin-2, malignant T cell amplification sequence 1, synaptic vesicle membrane protein VAT-1 homolog, calnexin,Parafibromin, transcription factor 12, extended synaptotagmin-1, spectrin beta chain, non-erythroid 4, COX assembly mitochondrial protein 2 homolog, lymphocyte cytosolic protein 2, DNA polymerase epsilon subunit 3, sorting nexin 1, BAG family molecular chaperone regulator 3, beta-enolase, RNA-binding tag, Protein 4, Destrin, Eukaryotic Translation Initiation Factor 1A, Y Chromosome, 5'-3' Exoribonuclease 2, Nucleoporin SEH1, Reticulon-4, 26S Protease Regulatory Subunit 6A, Heat Shock 70kDa Protein 4L, Cytoskeleton-Associated Protein 2, Coiled-Coil Domain-Containing Protein 124, Serine-Threonine Kinase Receptor-Associated Protein, 26S Proteasome Non-ATPase Regulatory Subunit 12, Ataxin-3, Polyglutamine-Binding Protein 1, Transcriptional Repressor p66-alpha, Paired Amphipathic Helix Protein Sin3a Sin3a), ribose-5-phosphate isomerase, transmembrane and coiled-coil domain-containing protein 1, dynein light chain roadblock type 1, Rho guanine nucleotide exchange factor 1, isocitrate dehydrogenase [NADP] cytoplasm, trifunctional enzyme subunit alpha, mitochondrial, cleavage stimulation factor subunit 2, telomeric repeat-binding factor 2-interacting protein 1, RNA-binding protein FUS, far upstream element-binding protein 3, TATA-binding protein-associated factor 2N, prosaposin, Myb-binding protein 1A, barrier-to-autointegration factorfactor), signal recognition particle subunit SRP68, protein FAM219A, tripeptidyl peptidase 1, HLA class I histocompatibility antigen, B-38 alpha chain, proteasome subunit beta type 7, neudecin, tubulin beta 6 chain, actin-related protein 2 / 3 complex subunit 3, solute carrier family 35 member F5, myoferlin, HLA class I histocompatibility antigen, B-44 alpha chain, fructose-bisphosphate aldolase B, neutral cholesterol ester hydrolase 1, FERM domain-containing protein 6, cyclic AMP-dependent transcription factor ATF-4, transcription factor AP-1, growth arrest and DNA damage-inducible protein GADD45 alpha, putative C-mannosyltransferase DPY19L4, integrin alpha-3, protein transporter protein Sec61 subunit alpha isoform 2, RhoGTPase-activating protein 7, exosome complex component RRP42, WD repeat-containing protein 48, protein LDOC1, BTB / POZ domain-containing protein KCTD4, DNA-binding protein SATB2, tribbles homolog 3, small nuclear ribonucleoprotein E, SH3 domain-binding glutamic acid-rich-like protein 3, HLA class II histocompatibility complex, DRB1-4 beta chain, HLA class I histocompatibility complex, Cw-4 alpha chain, fatty acid-binding protein, liver, polymeric immunoglobulin receptor, DAZ-associated protein 2, Lck-interacting transmembrane adaptor 1, cysteine-rich protein 2-binding protein, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, phosphatidylinositol 5-phosphate 4-kinase type 2 alpha, calsyntenin-3, Ras-related protein Rab-20, structure-specific endonuclease subunit Unit SLX4, myosin regulatory light polypeptide 9, centrosome-associated protein 350, StAR-related lipid transfer protein 5, WASH complex subunit 7, lysocardiolipin acyltransferase 1, puromycin-sensitive aminopeptidase-like protein, myocyte-specific enhancer factor 2D, ribosomal RNA processing protein 36 homolog, G1 / S-specific cyclin-D3, dipeptidyl peptidase 1, histone acetyltransferase KAT6A, putative ATP-dependent RNA helicase DHX57, histone arginine methyltransferase CARM1, myosin regulatory light chain 12A, cytochrome c oxidase subunit NDUFA4, Ras-related protein Rab-5B, dermcidin, RING finger and transmembrane domain-containing protein 2, inositol 1,4,5-trisphosphate receptor type 3, E3 ubiquitin protein ligase TRIM56, DNA repair protein (DNA repair protein) complementing XP-C cells. repair protein complementing XP-C cells), HLA class I histocompatibility antigens, B-35 alpha chain, ubiquitin-conjugating enzyme E2C, Bardet-Biedl syndrome 2 protein, protein S100-A8, zinc finger protein 608, BTB / POZ domain-containing protein KCTD1, RNA-binding protein with serine-rich domain 1, laminin subunit beta-3, UDP-N-acetylglucosamine-dolicholyl-phosphate N-acetylglucosamine phosphotransferase, DAZ-associated protein 1, ribosomal protein S6 kinase alpha-1, type II inositol 3,4-bisphosphate 4-phosphatase, zinc finger CCHC domain-containing protein 14, prefoldin subunit Knit 5, protein prenyltransferase alpha subunit repeat-containing protein 1, peroxisomal membrane protein PEX14, protein FAM134C, dolichol kinase, eukaryotic peptide chain release factor subunit 1, cyclin H, phosphorylated CTD interacting factor 1, Golgi-associated PDZ and coiled-coil motif-containing protein, protein farnesyltransferase / geranylgeranyltransferase type 1 subunit alpha, SPRY domain-containing protein 3, platelet-activating factor acetylhydrolase IB subunit alpha, elongation factor Tu GTP-binding domain-containing protein 1, protein RMD5 homolog B, putative E3 ubiquitin protein ligase HECTD4, KIF1-binding protein, cDNA FLJ25829 fis, clone TST08126, heat shock protein beta-1, serpin B12, S1 RNA-binding domain-containing protein 1, agrin, Abhydrolase domain-containing protein 2, muskelin, DNA polymerase delta catalytic subunit, zinc finger protein 419, angiomotin, protein Smaug homolog 22), N-acetylgalactosamine-6-sulfatase, putative C-mannosyltransferase DPY19L3, Src substrate cortactin, signal peptidase complex catalytic subunit SEC11A, matrin-3, NFX1-type zinc finger-containing protein 1, UPF0505 protein C16orf62, DNA damage-regulated autophagy modulator protein 2, semaphorin-4C, Niemann-Pick C1 protein, transmembrane 9 superfamily member 2, cyclin-dependent kinase 19, putative glutathione amino acid tRNA ligase, mitochondria, chondroitin sulfate proteoglycan 4, peroxisomal carnitine O-octanoyltransferase, WD repeat-containing protein 44, cytochrome c oxidase subunit 1, regulator of microtubule dynamics protein 1, GPI transamidase component PIG-S, ubiquitin protein ligase E3C, transcription elongation regulator 1, sorting nexin-9, N-acetylglucosamine-6-sulfatase, thymosin beta-4, integrin ral membrane protein GPR155, intraflagellar transport protein 122 homolog, calponin-3, inactive hydroxysteroid dehydrogenase-like protein 1, calcyclin-binding protein, F-box-only protein 31, MORN repeat-containing protein 1, leukocyte receptor cluster member 8, serine / threonine protein kinase NLK, histone acetyltransferase KAT6B, protein FAM26F, MORN repeat-containing protein 2, putative ATP-dependent RNA helicase YTHDC2, leucine-rich repeat-containing protein 1, sphingomyelin phosphodiesterase 2, myosin regulatory light chain 12B, sorting nexin-6, peptidyl-prolyl cis-trans isomerase-like 2, nucleolar GTP-binding protein 2, serine / threonine protein kinase MRCK alpha, 2-oxoisovalerate dehydrogenase subunit alpha, structural maintenance of mitochondria, chromosomal protein 1A, ubiquitin-like modifier activating enzyme 6, SAFB-like transcriptional modulator, putative heat shock protein HSP90 beta 2, ubiquitin-like protein 3, Kelch repeat and BTB domain-containing protein 6, WD repeat-containing protein 81, DDB1 and CUL4-associated factor 13, T-complex protein 11-like protein 1, aspartate-tRNA ligase, cytoplasmic, MAP kinase-activated protein kinase 2, thyroid receptor-interacting protein 11, clusterin-related protein 1, ubiquitin carboxyl-terminal hydrolase 32, low-density lipoprotein receptor class A domain-containing protein 3, homeodomain-interacting protein kinase 2, zinc finger protein 318, E3 ubiquitin protein ligase BRE1B, O-acetyl-ADP-ribose deacetylase 1, coiled-coil domain-containing protein 141, endoribonuclease Dicer, EVI5-like protein, MAP kinase-interacting serine / threonine protein kinase 2, nicotinamide phosphoribosyltransferase, fibronec Tin type III domain-containing protein 3B, alpha caturin, TOX high mobility group box family member 4, nuclear factor of activated T cells 5, elongation complex protein 5, protein FAM13A, transcription factor E2F3, tubulin-specific chaperone cofactor E-like protein, phospholipid scramblase 4, complex I intermediate-associated protein 30, mitochondrion, replication protein A 70 kDa DNA-binding subunit, adenylyl cyclase-associated protein 1, protein arginine N-methyltransferase 7, LIM domain kinase 2, NADPH-cytochrome P450 reductase, peptidyl-prolyl cis-trans isomerase D, ankyrin repeat and IBR domain-containing protein 1, regulator of small G protein signaling 2, protein-glutamate O-methyltransferase, zinc transporter 5, peptidyl-prolyl cis-trans isomerase FKBP8, eye absent homolog 33), nicotinamide riboside kinase 1, PCNA interacting partner, beta-mannosidase, putative ATP-dependent RNA helicase DDX17, synergin gamma, Kremen protein 2, guanine nucleotide exchange factor VAV3, DNA polymerase zeta catalytic subunit, histone acetyltransferase type B catalytic subunit, interferon regulatory factor 2-binding protein-like, protein YIF1B, ubiquitin carboxyl-terminal hydrolase 8, group XV phospholipase A2, putative C-mannosyltransferase DPY19L1, putative E3 ubiquitin protein ligase HERC1, iduronate 2-sulfatase, type 2 lactosamine alpha -2,3-sialyltransferase, protein FAM65B, protein RCC2, DNA ligase 3, FAS-related factor 1, geranylgeranyltransferase type 2 subunit alpha, CLIP-related protein 2, zinc finger protein 746, G-patch domain and KOW motif-containing protein, retinoid-inducible serine carboxypeptidase, Kelch-like protein 15, trafficking protein particle complex subunit 3, Xaa-Pro aminopeptidase 1, PMS1 protein homolog 1, SEC23-interacting protein, syndetin, CDK5 regulatory subunit-associated protein 3, endophilin-B1, GON-4-like protein, MH C class I polypeptide-related sequence A, zinc finger protein 5 with KRAB and SCAN domains, zinc finger CW-type PWWP domain protein 1, conserved oligomeric Golgi complex subunit 6, nonconventional myosin-Va, N6-adenosine methyltransferase 70 kDa subunit, arylamine N-acetyltransferase 1, CD82 antigen, lathosterol oxidase, synembryn-B, mitochondrial enolase superfamily member 1, serine / threonine protein kinase N2, Hermansky-Pudlak syndrome 1 protein, protein 4.1, lysine-specific demethylase 2A, TP53-regulated kinase, tubulin beta 4B chain, integrin alpha V, protein disulfide isomerase A5, oligoribonuclease, mitochondria, protein furry homolog-likehomolog-like), N-alpha-acetyltransferase 16, NatA auxiliary subunit, trophinin, vacuolar protein sorting-associated protein 13C, F-box / LRR-repeat protein 14, F-box / LRR-repeat protein 17, transmembrane protein 218, protein unc-13 homolog B, RNA-binding protein Raly, interferon-inducible protein with tetratricopeptide repeats 1, mitochondrial import receptor subunit TOM70, RNA polymerase II-associated factor 1 homolog, cytokine receptor-like factor 3, cytosolic aminopeptidase, protein zyg-11 homolog B, N-acetylglucosamine-1-phosphotransferase subunit alpha / beta, protein transport protein Sec61 subunit alpha isoform 1, mitogen-activated protein kinase kinase kinase 7, intraflagellar transport protein 43 homolog, zinc finger protein 627, zinc finger protein 614, zinc Kfinger protein 324B, S100P-binding protein, early endosomal antigen 1, phospholipid scramblase 1, sialidase 1, inhibitor of nuclear factor kappa B kinase subunit beta, deoxyribose phosphate aldolase, Rho-associated BTB domain-containing protein 3, ribosomal protein S6 kinase delta 1, nucleoporin NDC1, importin-7, cyclin-dependent kinase 2-associated protein 1, PAS domain-containing serine / threonine protein kinase, vacuolar protein sorting-associated protein 18 homolog, transmembrane and TPR repeat-containing protein 3, alpha / beta hydrolase domain-containing protein 17B, immediate early response gene 5-like protein, casein kinase II subunit alpha, DNA excision repair protein ERCC-6-like 2, 3'(2'),5'-diphosphate nucleotidase 1, MAP kinase-activating death domain protein, dynactin subunit 2, mucosa-associated lymphoid tissue lymphoma metastasis protein 1 (Mucosa-associated lymphoid tissue lymphoma metastasis protein 1) lymphoid tissue lymphoma translocation protein1), putative deoxyribonuclease TATDN1, interferon regulatory factor 3, tubulin polyglutamylase complex subunit 2, regulator of microtubule dynamics protein 3, putative histidine tRNA ligase, mitochondria, 39S ribosomal protein L52, mitochondria, tectonin beta-propeller repeat-containing protein 2, 7SK snRNA methylphosphate capping enzyme, proline-rich nuclear receptor coactivator 1, ubiquinone biosynthesis protein COQ9, mitochondria, clustered mitochondrial protein homolog, dexamethasone-inducible protein, semaphorin-4F, fatty acid-binding protein, epidermis, acyl amino acid releasing enzyme, zinc finger MYM-type protein 4, YTH domain-containing family protein 3, A-kinase anchor protein 6, lambda crystallin homolog, telomerase protein component 1, DNA helicase B, presenilin-1, zinc finger protein 428, NF-kappa B inhibitor, putative ATP-dependent RNA helicase DHX35, proline 3-hydroxylase OGFOD1, N-alpha-acetyltransferase 20, E3 ubiquitin-protein ligase RNF135, thrombospondin-3, NADH-ubiquinone oxidoreductase chain 5, 52 kDa repressor of protein kinase inhibition, homeodomain-interacting protein kinase 1, serine / threonine protein kinase RIO3, YY1-related protein 1, myosin 14, LIM domain and actin-binding protein 1, zinc finger protein 462, protein YIPF5, putative SMEK homolog 3, charged multivesicular body protein 4b, microphthalmia-associated transcription factor, unhealthy ribosome biogenesis protein 2 homologhomolog), putative 28S rRNA (cytosine-C(5))-methyltransferase, vesicle-associated membrane protein 7, leucyl-cystinyl aminopeptidase, mitogen-activated protein kinase kinase kinase kinase kinase 2, GRAM domain-containing protein 4, nuclear factor erythroid 2-related factor 1, uncharacterized protein KIAA2013, lysophospholipid acyltransferase LPCAT4, actin-associated protein 6, hepatocyte growth factor-regulated tyrosine kinase substrate, zinc finger protein 74, phosphofuranose-dependent cluster sorting protein 1, PH domain leucine-rich repeat-containing protein phosphatase 2, HMG box-containing protein 1, aryl hydrocarbon receptor, LIM and SH3 domain protein 1, E3 ubiquitin protein ligase synoviolin, vacuolar protein sorting-associated protein 13D, ubiquitin carboxyl-terminal hydrolase 25, RNA polymerase-associated protein CTR9 homolog, charged multivesicular body protein Protein 7, RAB6A-GEF complex partner protein 2, UDP-glucose:glycoprotein glucosyltransferase 1, DNA-directed RNA polymerase II subunit RPB9, nitric oxide synthase, endothelial, peptidyl-prolyl cis-trans isomerase FKBP3, ubiquitin carboxyl-terminal hydrolase 15, WASH complex subunit strumpellin, selenocysteine ​​insertion sequence-binding protein 2-like, nuclear cap-binding protein subunit 2, methyltransferase-like protein 22, F-box-only protein 9, DmX-like protein 2, ectonucleotide pyrophosphatase / phosphodiesterase family member 2, creatine kinase type B, protein FAM91A1, paired-box protein Pax-3, integrin beta-3, protein SEC13 homolog, histone lysine N-methyltransferase SETDB2, Scm-like protein with four MBT domains 1 (Scm-like) with four MBT domains protein 1, forkhead box protein M1, protein kinase C and neuronal casein kinase substrate inneurons protein 2), clathrin interactor 1, protein FAM189B, nuclear receptor-interacting protein 1, centriole, cilia and spindle-associated protein, ubiquitin carboxyl-terminal hydrolase 38, recombining binding protein suppressor of hairless, Holliday junction recognition protein, integrin alpha-5, immunoglobulin superfamily member 8, signal-induced growth-associated 1-like protein 1, eukaryotic translation initiation factor 2A, mitochondrial import inner membrane translocase subunit Tim17-A, protein strawberry notch homolog 1, splicing factor 3B subunit 6, glutamine tRNA ligase, BRCA2-interacting transcriptional repressor EMSY, E3 SUMO protein ligase NSE2, retinal dehydrogenase 1, alpha-N-acetylglucosaminidase, E3 SUMO protein ligase RanBP2, endoplasmic reticulum metallopeptidase 1, leucine-rich repeat flightless-interacting protein 1, uncharacterized protein C15orf41, high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, sodium / potassium transporting ATPase subunit alpha-2, neuroplastin, leukotriene A-4 hydrolase, DNA-directed RNA polymerase I and III subunit RPAC1, mitotic spindle assembly checkpoint protein MAD2A, exosome complex component RRP4, SET domain-containing protein 4, transmembrane protein 70, mitochondria, mitotic spindle assembly checkpoint protein MAD1, akirin 2, BCL2 / adenovirus E1B 19kDa protein-interacting protein 2, U3 small nucleolar RNA-associated protein 15 homolog, fascin, proteasome subunit alpha type 7, 14-3-3 protein epsilon, spindlin-3, LETM1 and EF-hand domain-containing protein 1, mitochondrial, nucleolar protein 14, ubiquitin-conjugating enzyme E2Z, elongation complex protein 1, DNA repair protein XRCC4, importin 5, splicing factor 1, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, acetyl-coenzyme A transporter 1, zinc finger protein 275, E3 ubiquitin protein ligase HACE1, AT-rich interactive domain-containing protein 2, tetraspanin 33, peroxisome assembly factor 2, oral-facial-digital syndrome type 1 protein (OFDS1) protein, nuclear factor of activated T cells, cytoplasmic 1, TBC1 domain family member 8, protein MEF2BNB, complex I assembly factor TMEM126B, mitochondria, DNA polymerase delta subunit 3, gamma secretase subunit APH-1A, Bcl-2 modifier, epididymis-specific alpha mannosidase, Ras association domain-containing protein 3, uncharacterized protein C15orf61, spindlin-1, cholinesterase, acetyl-CoA carboxylase 1, transmembrane protein 87A, lysyl oxidase homolog 3, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 1-related), prostamide / prostaglandin F synthase, E3 ubiquitin protein ligase TRIM4, MAGUKp55 subfamily member 2, far upstream element-binding protein 1, dimethylaniline monooxygenase [N-oxide forming] 4, dihydropyrimidine dehydrogenase [NADP(+)], spermatogenesis-related protein 20, AN1-type zinc finger protein 6, YTH domain-containing family protein 1, SUN domain-containing protein 2, 45 kDa calcium-binding protein, integrator complex subunit 6, Protein Lines homolog 1, proline-rich protein 7, zinc finger MIZ domain-containing protein 2, RNA-binding protein Protein 5, serine / arginine-rich splicing factor 10, tetraspanin-4, ribosomal RNA small subunit methyltransferase NEP1, presenilin-2, prolyl 3-hydroxylase 2, mitogen-activated protein kinase kinase kinase 1, coiled-coil domain-containing protein 121, osteoclast-stimulating factor 1, 39S ribosomal protein L35, mitochondria, UDP-N-acetylhexosamine pyrophosphorylase-like protein 1, RNA-binding protein 39, thioredoxin-like protein AAED1, eukaryotic translation initiation factor 3 subunit K, protein timeless homolog, zinc finger and BTB domain-containing protein 6, ATP-binding cassette subfamily A member 3, vinculin, microtubule-associated protein 1A, c-Jun amino-terminal kinase-interacting protein 2, plakophilin-2, 39S ribosomal protein L34, mitochondria, Ras-related protein Rab-27A, serine / threonine-protein kinase Tousled-like 1 kinase tousled-like 1, protein S100-A4, centriolin, transcriptional repressor CTCF, golgin subfamily A member 3, death-inducer obliterator 1, glycogen debranching enzyme, transmembrane protein 181, A-kinase anchor protein 9, E3 ubiquitin protein ligase MYLIP, guanine nucleotide-binding protein G(i) subunit alpha-2, peptidyl prolyl cis-trans isomerase FKBP4, metaxin-1, uncharacterized protein KIAA1143, disabled homolog 2, serine / threonine protein kinase tousled-like 2, squamous cell carcinoma antigen recognized by T cells 3, natural resistance-associated macrophage protein 2, S-adenosyl-L-methionine-dependent tRNA4-Demethylwyosine synthase, Puromycin-sensitive aminopeptidase, Protocadherin gamma-A11, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, Protocadherin lipid 1, H(+) / Cl(-) exchanger 7, Zinc finger protein 407, Desmoplakin, Kelch-like protein 7, H(+) / Cl(-) exchanger 3, Protein phosphatase 1 regulatory subunit 3C, Interleukin-17 receptor C, Solute carrier family 22 member 18, Sodium / potassium ATP-transporting ATPase subunit beta 1, ATP-binding cassette subfamily B member 8, mitochondria, sorbin and SH3 domain-containing protein 2, histidine tRNA ligase, cytoplasm, putative cation-transporting ATPase 13A2, nonconventional myosin-Ib, MAP / microtubule affinity-regulating kinase 3, NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria, ceramide synthase 5, transcription intermediary factor 1-beta, arginine-tRNA ligase, cytoplasm, neurosecretory protein VGF, U8 snoRNA decapping enzyme, epididymal secretory protein E1, phenylalanine tRNA ligase alpha subunit, zinc finger protein 536, vascular endothelial growth factor A, decapping and exoribonuclease protein, glia-derived nexin, PITH domain-containing protein 1, gamma-aminobutyric acid receptor subunit beta-3, lysine-specific demethylase 3B, protein diaphanous homolog 2, nuclear protein localization protein 4 homolog, aldehyde dehydrogenase family 1 member A3, ubiquitin-like protein 5, zinc finger BED domain-containing protein 5, RhoGTPase-activating protein 5, tyrosine protein phosphatase non-receptor type 1, ATP-dependent RNA helicase DDX18, chromosomal protein structural maintenance 2, dihydropyrimidinase-related protein 1, mitochondrial import receptor subunit TOM20 homolog, ADP-ribosylation factor 3, WD repeat-containing protein 26, mitogen-activated protein kinase kinase kinase 3, zinc finger protein 579, uridine phosphorylase 1, MORF4 family-related protein 1, exocyst complex component 1, keratin, type I cytoskeleton 10, Rho GTPase-activating protein 18, mitotic checkpoint serine / threonine protein kinase BUB1, transmembrane protein 131, ceramide synthase 6, MICOS complex subunit MIC25, E3 ubiquitin protein ligase RNF114, JNK1 / MAPK8-associated membrane protein, coiled-coil domain-containing protein 14, brefeldin A-inhibitory guanine nucleotide exchange protein 2, exosome complex component MTR3, PR domain zinc finger protein 4, protein CutA, trafficking protein particle complex subunit 2-like protein, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, cyclin-dependent kinase 2-associated protein 2, wings apart-like protein homolog, pre-mRNA splicing factor ATP-dependent RNA helicase PRP16, and two-pore calcium channel protein 1. 1), DNA / RNA-binding protein KIN17, ribonucleoprotein PTB-binding 1, sterol regulatory element-binding protein 1, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4, proline-rich nuclear receptor coactivator 2, zinc finger protein 526, ProteinWiz (ProteinWiz), PHD finger protein 23, carboxymethylenebutenolidase homolog, protein phosphatase 1 regulatory subunit 15B, putative PIP5K1A and PSMD4-like protein, acyl-protein thioesterase 1, alpha-1,2-mannosyltransferase ALG9, ankyrin repeat domain-containing protein 10, endoplasmic reticulum transport protein SEC20, triple function domain protein, inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinase 1, putative ATP-dependent RNA helicase DDX10, zinc finger protein 292, leucine-rich repeat and calponin homology domain-containing protein 3, calcium-binding protein 39, small integral membrane protein 15, protein phosphatase 1A, ATP-dependent RNA helicase DHX29, structural maintenance of chromosomes protein 6 6), caldesmon, REST corepressor 1, calmodulin-like protein 4, F-box / WD repeat-containing protein 5, zinc finger RNA-binding protein, L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, Hom s 5, harmonin, tRNA selenocysteine ​​1-related protein 1, vacuolar protein sorting-associated protein 35, argininosuccinate synthase, RNA-binding protein 3, 40S ribosomal protein S6, myosin-11, carbonic anhydrase 12, myosin-10, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, electrogenic sodium bicarbonate cotransporter 11), epidermal growth factor receptor, 39S ribosomal protein L49, mitochondria, ELKS / Rab6-interacting / CAST family member 1, statherin, ATP-dependent RNA helicase DDX1, 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 3, formin-like protein 3, elongator complex protein 2, prostaglandin G / H synthase 1, ATP-dependent DNA helicase Q5, nucleolar protein 10, thioredoxin-like protein 1, ETS translocation mutant 3, actin, alpha skeletal muscle, KAT8-regulated NSL complex subunit 3, neutral and basic amino acid transporter protein rBAT, myotubularin-related protein 2, glutathione S-transferase Mu4, ADP-ribosylation factor-like protein 2-binding protein, A-kinase phase interacting protein 1, sorting nexin 7, serine protein kinase ATM, poly[ADP-ribose] polymerase, piezo-type mechanosensitive ion channel component 1, multidrug resistance-associated protein 1, glutathione-specific gamma-glutamyl cyclotransferase 1, macrophage metalloelastase, SURP and G-patch domain-containing protein 1, factor VIII intron 22 protein, succin, epithelial discoidin domain-containing receptor 1, pseudouridylate synthase 7 homolog-like protein, La-associated protein 1, adenylate kinase 2, mitochondria, ATR-interacting protein, transmembrane protein 41B, protein SZT2, transient receptor potential cation channel subfamily V member 2, phosphatidylcholine translocator ABCB4, Ras GTPase-activating-like protein IQGAP2, F-box DNA helicase 1, Fas inhibitor of apoptosis molecule 1, interferon regulatory factor 2-binding protein 2, inactive serine / threonine protein kinase VRK3, complement C1q tumor necrosis factor-related protein 3, coiled-coil domain-containing protein 106, LIM and senescent cell antigen-like-containing domain protein 11), fibrinogen alpha chain, cytospin-B, DNA-directed RNA polymerase III subunit RPC7, regulator of nonsense transcripts 1, keratin, type II cytoskeleton 2 epidermis, Gem-related protein 4, histone lysine N-methyltransferase ASH1L, MORC family CW-type zinc finger protein 4, C-terminal binding protein 2, basic salivary proline-rich protein 2, salivary acidic proline-rich phosphoprotein 1 / 2, histone chaperone ASF1A, beclin-1, putative methyltransferase-like protein 15P1, putative peripheral benzodiazepine receptor-associated protein, protein FAM216A, AP-2 complex subunit beta, PHD and RING finger domain-containing protein 1, E3 ubiquitin protein ligase TRAF7, voltage-dependent anion-selective channel protein 3, F-box / WD repeat-containing protein 11, protein O-GlcNAcase, tubulin folding cofactor B, activation signal cointegrator 1 complex subunit 1, polypyrimidine tract-binding protein 2, mitochondrial genome maintenance exonuclease 1, NEDD4-binding protein 2-like 1, zinc finger and BTB domain-containing protein 38, protein sel-1 homolog 3, Repressor of RNA polymerase III transcription MAF1 homolog, versican core protein, histone lysine N-methyltransferase 2E, endothelial PAS domain-containing protein 1, histone lysine N-methyltransferase NSD2, amyloid-like protein 2, transcription initiation factor TFIID subunit 4, cysteine- and histidine-rich protein 1, formin-like protein 2, KRR1 small subunit process component ent homolog, V-type proton ATPase 116 kDa subunit a isoform 3, dimecrin, histone deacetylase 4, solute carrier family 2, facilitated glucose transporter member 1, tripeptidyl peptidase 2, putative UDP sugar transporter protein SLC35A5, putative ATP-dependent RNA helicase DDX60-like, cystatin A, splicing factor U2AF 65 kDa subunit, membrane-associated transcription factor site 1 protease, UBX domain-containing protein 4, kinesin-like protein KIF11, FAST kinase domain-containing protein 2, LEM domain protein 2, galectin-3, solute carrier family 12 member 6, BCL2 / adenovirus E1B 19 kDa protein-interacting protein 3, serine / threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Bardet-Biedl syndrome 4 protein, progestin and adipoQ receptor family member 4, 40S ribosomal protein S23, peroxisomal membrane protein PMP34, polycystic kidney disease and egg jelly-related protein receptor, protein red, protein KHNYN, 40S ribosomal protein S15, putative methyltransferase NSUN6, Sin3 histone deacetylase corepressor complex component SDS3, protein S100-A10, melanoma-associated antigen D4, calcium / calmodulin-dependent protein kinase type IV, E3 ubiquitin-protein ligase RNF19B, gardin, testin, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1), calcium uptake protein 2, mitochondrial, tetratricopeptide repeat protein 25, inhibitor of growth protein 5, son of sevenless homolog 2, trans-Golgi network integral membrane protein 2, insulin-like growth factor 2mRNA-binding protein 3, transcription factor SOX-8, serine / threonine protein kinase DCLK2, golgin subfamily A member 5, TBC1 domain family member 13, HLA class II histocompatibility antigen, DR beta 5 chain, E3 SUMO protein ligase CBX4, PWWP domain-containing protein MUM1, interferon-induced transmembrane protein 2, DNA polymerase kappa, methionine synthase, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD / H box 1 1), translocation protein SEC63 homolog, chromodomain Y-like protein, procollagen lysine, 2-oxoglutarate 5-dioxygenase 2, F-box only protein 28, tripartite motif-containing protein 34, tubulin tyrosine ligase, DNA topoisomerase 3-beta-1, Hermansky-Pudlak syndrome 3 protein, G / T mismatch-specific thymine DNA glycosylase, transducin beta-like protein 3, negative regulator of reactive oxygen species, BAG family molecular chaperone regulator 2, ganglioside GM2 activator, RNA-binding protein 12B, beta-galactoside alpha-2,6-sialyltransferase 1, dynactin subunit 5, N-terminal Xaa-Pro-Lys N-methyltransferase 1, Ran-binding protein 9, E3 ubiquitin protein ligase RNF216, SET domain-containing protein 5, F-box / WD repeat-containing protein 7, TRIO and F-actin binding protein, pleckstrin homology domain-containing family A member 2, beta-actin-like protein 2, stimulator of interferon genes protein, putative V-set and immunoglobulin domain-containing like protein IGHV4OR15-8, Ig kappa chain VI region HK102, arachidonate 5-lipoxygenase, U2snRNP-associated SURP motif-containing protein, HLA class I histocompatibility antigen, A-3 alpha chain, nuclear pore complex protein Nup50, trinucleotide repeat-containing gene 6B protein, four and a half LIM domains protein 2, protein disulfide isomerase, radial spoke head protein 3 homolog, collagen alpha-3(VI) chain, synaptobrevin homolog YKT6, myotubularin-related protein 6, polypeptide N-acetylgalactosaminyltransferase 2, cytochrome c oxidase subunit 5B, mitochondria, Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase, serglycin, UDP-glucuronic acid decarboxylase 1, integrin beta-2, forkhead-associated domain-containing protein 1 1), zinc finger protein 36, C3H1 type-like 2, chloride intracellular channel protein 6, Rab3GTPase-activating protein non-catalytic subunit, guanylate-binding protein 4, cell division control protein 42 homolog, 40S ribosomal protein S27-like, septin-9, macrosialin, serine / threonine protein kinase RIO1, transcription elongation factor protein 1, transmembrane protein 14A, protein nepro homolog, torsin-4A, protein CEBPZOS, HLA class I histocompatibility antigen, B-57 alpha chain, Ras-related protein M-Ras, DNA polymerase delta subunit 2, zinc finger protein 343, ADP-ribosylation factor 6, discoidin, CUB and LCCL domain-containing protein 2, deoxyhypusine synthase, lysophospholipid acyltransferase 5, nuclear cap-binding protein subunit 1, 40S ribosomal protein S27, serpin H1, tetratricopeptide repeat protein 30A, A-kinase anchor protein 8-like, actin-associated protein 3, inositol-tetrakisphosphate 1-kinase, STE20-related kinase adduct Adapter protein alpha, grancalcin, transcriptional repressor p66-beta, cytochrome b-245 heavy chain, lanosterol synthase, protein phosphatase 1 regulatory subunit 12A, protein FAM168A, HLA class II histocompatibility antigen, DRB1-16 beta chain, rotatin, histone H2A type 1-B / E, SH3 domain-binding glutamic acid-rich-like protein, WD repeat domain phosphoinositide-interacting protein 3, lysine-specific demethylase 6B, poly[ADP-ribose] ] polymerase 8, intraflagellar transport protein 25 homolog, histone lysine N-methyltransferase setd3, Rho guanine nucleotide exchange factor 12, cell division cycle protein 16 homolog, ATP-dependent zinc metalloprotease YME1L1, ubiquitin thioesterase OTUB1, homeobox-containing protein 1, protein FAM162A, group XIIB secretory phospholipase A2-like protein, SH3 domain-binding protein 2, 14-3-3 protein eta, CTTNBP2N-terminal-like protein, claspin, ADP-ribosylation factor 4, geranylgeranyltransferase type 1 subunit beta, galectin-2, CAAX prenyl protease 1 homolog, phospholipase D1, DNA-directed RNA polymerase III subunit RPC4, serine / threonine protein kinase MARK2, FGFR1 oncogene partner 2, 4F2 cell surface antigen heavy chain, bromodomain-containing protein 8, mitochondrial coenzyme A transporter SLC25A42, terminal uridyltransferase 7, hiscin, serine / threonine protein phosphatase 2B catalytic subunit beta isoform, transcription factor SOX-9, F-box / LRR linker PEAT protein 6, adiponectin receptor protein 1, ribosomal protein S6 kinase beta-1, zinc finger protein 655, putative aminopeptidase NPEPL1, dolicholyl diphosphooligoglycoprotein glycosyltransferase subunit 1, nuclear transcription factor Y subunit gamma, COUP transcription factor 2, chromodomain helicase DNA-binding protein 1, glycogen phosphorylase, brain type, a disintegrin and metalloproteinase domain-containing protein 23, insulin-like growth factor I, centrin-specific protease 2, actin, alpha cardiac muscle 1, apoptosis-inducing factor 1, mitochondria, toothless protein homolog (Denticleless) protein homolog), sarcoplasmic / endoplasmic reticulum calcium ATPase 2, chromodomain helicase-DNA binding protein 3, histone-lysine N-methyltransferase EHMT1, mediator of RNA polymerase II transcription subunit 6, chromatin complex subunit BAP18, anaphase-promoting complex subunit 16, exocyst complex component 6, dehydrodolicholyl diphosphate synthase complex subunit NUS1, tetratricopeptide repeat protein 27, DNA-directed RNA polymerase II subunit RPB11-b2, tensin-1, keratin, type I cytoskeleton 19, UPF0568 protein C14orf166, and Disheveled-associated activator of morphogenesis1), thiopurine S-methyltransferase, tuftelin, autophagy-related protein 9A, serine / threonine protein phosphatase 6-regulatory ankyrin repeat subunit C, leucine-rich repeat-containing protein 41, transmembrane protein 50A, snRNA-activator protein complex subunit 4, galectin-8, WAS / WASL-interacting protein family member 1, ATP synthase F(0) complex subunit C2, mitochondria, MIT domain-containing protein 1, 28S ribosomal protein S24, mitochondria, glycine-tRNA ligase, ubiquitin protein ligase E3A, bifunctional polynucleotide phosphatase / kinase, serine / threonine protein kinase PLK2, ubiquitin carboxyl-terminal hydrolase 16, cholesteryl ester transfer protein, Rho GDP dissociation inhibitor 1, F-box / LRR repeat protein 19, interleukin-12 subunit alpha, tumor necrosis factor receptor superfamily member 19, 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, protein phosphatase 1 regulatory subunit 15A, transmembrane protein 140, DNA damage-inducible transcript 4 protein, tetratricopeptide repeat protein 28, beta-2-syntrophin, jouberin, ribose phosphate pyrophosphokinase 1, inactive tyrosine protein kinase 7, protein LYRIC, HLA class I histocompatibility complex, alpha chain G, transcriptional adaptor 2-alpha, myeloid cell nuclear differentiation antigen, integrin beta-1, solute carrier family 25 member 43, UDP-N-acetylglucosamine transporter, zinc finger protein 573, ubiquitin binding Enzyme E2 E1, all-trans-retinol 13,14-reductase, laminin subunit gamma 1, bromodomain and WD repeat-containing protein 1, ATP-dependent RNA helicase DDX51, cytosolic purine 5'-nucleotidase, sterol regulatory element-binding protein cleavage activating protein, tankyrase-1, zinc finger protein 609, M-phase inducer phosphatase 2, uncharacterized protein C8orf59, intraflagellar transport protein 27 homolog, RNA-binding motif, single-strand interacting protein 2, S-phase kinase-associated protein 1, mitochondrial fission process protein 1, protein SHQ1 homolog, carbo Oxypeptidase Q, serine / threonine protein kinase 10, cardiolipin synthase (CMP formation), splicing regulatory glutamine / lysine-rich protein 1, ATP-binding cassette subfamily A member 7, AT-rich interactive domain-containing protein 1B, sodium / potassium transporting ATPase subunit beta 3, RING finger protein 214, UDP-glucuronosyltransferase 1-10, developmentally regulatory GTP-binding protein 2, transcription factor Maf, serine / threonine protein kinase 35, GRIP and coiled-coil domain-containing protein 2, transcription factor IIIB 90kDa subunit, TAF6-like RNA polymerase II p300 / CBP-associated factor-associated factor 65kDa subunit 6L, serine / threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B, ankyrin repeat domain-containing protein 27, zinc finger protein 148, glutamic acid-rich WD repeat-containing protein 1, TBC domain-containing protein kinase-like protein, enhancer of mRNA decapping protein 4, quinone oxidoreductase-like protein 1, transcription initiation factor TFIID subunit 2, beta-hexosaminidase subunit beta, transmembrane protein 234, 28S ribosomal protein S29, mitochondrial, CAS1 domain-containing protein 1, ubiquitin carboxyl-terminal hydrolase 4,Biogenesis of lysosome-related organelle complex 1 subunit 3, ankyrin repeat domain-containing protein 11, zinc finger and homeobox protein 2, hepatoma-derived growth factor, cancer / testis antigen 2, histone deacetylase 6, conserved oligomeric Golgi complex subunit 7, striatin-4, tricarboxylate transport protein, mitochondria, general transcription factor IIF subunit 2, RNA demethylase ALKBH5, phosphatidylinositide phosphatase SAC2, tRNA splicing endonuclease subunit Se n34, WAS / WASL-interacting protein family member 2, protocadherin gamma-C3, round spermatid basic protein 1-like protein, alpha-mannosidase 2C1, transcription factor p65, serine protease 23, splicing factor, arginine / serine-rich 15, neuropathy target esterase, tubulin epsilon chain, MICOS complex subunit MIC13, endonuclease domain-containing 1 protein, sodium-dependent phosphate transport protein 4, deubiquitinating protein Protein VCIP135, 220 kDa kinase D interacting substrate, multivesicular body subunit 12A, heterogeneous nuclear ribonucleoprotein D-like, gamma-adducin, nucleotide exchange factor SIL1, protein FAM76B, nuclear division apparatus protein 1, isoaspartyl peptidase / L-asparaginase, chromobox protein homolog 2, cilium and flagella associated protein 97, heme binding protein 1, SCY1-like protein 2, E3 ubiquitin protein ligase RNF123, transcription termination factor 1, COP9 signalosome complex subunit 4, UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit, conserved oligomeric Golgi complex subunit 2, Rho-associated protein kinase 2, uncharacterized protein C1orf43, protein FAM179B, cyclic AMP-responsive element-binding protein 1, endothelin-converting enzyme 1, torsin1A-interacting protein 1, ATP-binding cassette subfamily E member 1,5'-3' exoribonuclease 1, MAX gene-related protein, protein MAK16 homolog, Arf-GAP domain with Rho-GAP, ANK repeat and PH domain-containing protein 3, lysine-specific demethylase 5B, signal recognition particle 9 kDa protein, DnaJ homolog subfamily C member 16, CSC1-like protein 1, 39S ribosomal protein L38, mitochondria, golgin subfamily A member 2, N-alpha-acetyltransferase 25, NatB auxiliary subunit, ADP-ribosylation factor-like protein 2, protein Asterix, Dapper homolog 1 1), transmembrane protein 64, transcription factor EB, magnesium transporter NIPA2, DnaJ homolog subfamily C member 8, membrane-bound transcription factor site-2 protease, coiled-coil domain-containing protein 134, kynurenine 3-monooxygenase, peptidyl-prolyl cis-trans isomerase F, mitochondria, GH3 domain-containing protein, AF4 / FMR2 family member 1, trafficking protein particle complex subunit 9, calcineurin B homologous protein 1, poly(ADP-ribose) glycohydrolase ARH3, TERF1-interacting nuclear factor 2, prefoldin subunit 2, pumilio homolog 1 (Pumilio homolog 1) 1), Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2, protein CMSS1, beta-lactamase-like protein 2, ERO1-like protein alpha, protein SLX4IP, vacuolar protein sorting-associated protein 8 homolog, RING finger protein 145, type II inositol 1,4,5-trisphosphate 5-phosphatase, transmembrane anterior posterior transformation protein 1 homolog, glutamyl tRNA (Gln) amidotransferase subunit A, mitochondrial, G1 / S-specific cyclin D2, transcription termination factor 1, mitochondrial, sterol 26-hydroxylase, mitochondrial, alpha / beta hydrolase domain-containing protein 17C, PHD finger protein 10,SNF-related serine / threonine protein kinase, transcription initiation factor TFIID subunit 1-like, shootin-1, glucocorticoid receptor, histone H2A deubiquitinase MYSM1, CD9 antigen, calcium signal-regulating cyclophilin ligand, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6, tyrosyl-DNA phosphodiesterase 2, 60 kDa SS-A / Ro ribonucleoprotein, insulin degrading enzyme, cytosolic 5'-nucleotidase 3A, mediator of RNA polymerase II transcription subunit 26, ribosomal protein S6 kinase alpha-3, DNA polymerase eta, glycylpeptide N-tetradecanoyltransferase 1, DNA-directed RNA polymerase I, II, and III subunit RPABC1, volume-regulatory anion channel subunit LRRC8D, peptide-N(4)-(N-acetyl-beta-glucosaminyl) asparagine amidase, GA-binding protein subunit beta-1, reverse formin-2, oxysterol-binding protein, phospholipid hydroperoxide glutathione peroxidase, mitochondria, chromatin assembly factor 1 subunit B, putative heat shock protein HSP90-alphaA5, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Rho GTPase-activating protein 4, WD repeat-containing protein 47, putative ubiquitin carboxyl-terminal hydrolase FAF-X, endoplasmic reticulum aminopeptidase 1, HEAT repeat-containing protein 1, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, serine / threonine protein kinase 11-interacting protein, atlastin-3, glycerol-3-phosphate acyltransferase 4, bifunctional coenzyme A synthase, arginyl aminopeptidase-like 1, acidic leucine-rich nuclear phosphoprotein 32 family member A, mannosyl oligosaccharide glucosidase, rRNA methyltransferase 1, mitochondrial tRNA splicing endonuclease subunit Sen15, Ecto-NOX disulfide-thiol exchanger 1, zinc finger protein 662, glutamine-fructose-6-phosphate aminotransferase [isomerization]2,Transcription intermediary factor 1-alpha, nicotinate phosphoribosyltransferase, 5-aminolevulinic acid synthase, nonspecific, mitochondrial, actin-binding protein anillin, putative deoxyribonuclease TATDN3, WD repeat-containing protein 61, protein SCAF8, MKL / myocardin-like protein 2, TRPM8 channel-associated factor 2, rapamycin-insensitive companion of mTOR, nuclear receptor subfamily 2 group C member 2, lysophospholipid acyltransferase 7, complex I assembly factor TIMMD C1, mitochondria, KATNB1-like protein 1, putative ATP-dependent RNA helicase DHX30, RNA-binding protein 12, transmembrane protein 214, PHD finger protein 3, COP9 signalosome complex subunit 5, neutral amino acid transporter A, AP-5 complex subunit beta 1, PX domain-containing protein kinase-like protein, putative inactive carbonic anhydrase 5B-like protein, small integral membrane protein 4, DNA crosslink repair 1A protein, Mothers against decapentaplegic homolog 2, TIP41-like protein, retinol dehydrogenase 10, Hippocampus abundant transcript-like protein 1), N-acetyltransferase 9, MOB kinase activator 3A, transcriptional repressor protein YY1, Kelch-like protein 6, squalene synthase, N-alpha-acetyltransferase 38, NatC auxiliary subunit, dedicator of cytokinesis protein 2, E3 ubiquitin protein ligase TRIM11, tRNA-specific adenosine deaminase 1, transmembrane protein 248, E3 ubiquitin protein ligase RNF167, uncharacterized protein C20orf196, polycomb protein EED, exosome complex component RRP46, Kelch-like protein 11, POTE ankyrin domain family member I, activity-dependent neuroprotective homeobox protein, DNA-binding protein inhibitor ID-4, cecernin-2, ETS-related transcription factor Elf-1, TCDD-inducible poly[ADP-ribose] polymeraseproliferation-related protein 2G4, NudC domain-containing protein 1, ATPase family AAA domain-containing protein 2B, zinc finger and homeobox protein 3, methylmalonyl-CoA mutase, mitochondrial, protein RRNAD1, phospholipase A-2 activating protein, glycerol-3-phosphate acyltransferase 3, protein FAM122B, uncharacterized protein KIAA1, 109, phenylalanine-tRNA ligase, mitochondria, serine / threonine protein phosphatase 2B catalytic subunit alpha isoform, thioredoxin domain-containing protein 11, bladder cancer-associated protein, membrane cofactor protein, nuclear factor of activated T cells, cytoplasmic 2, Smith-Magenis syndrome chromosomal region candidate gene 8 protein, Krueppel-like factor 3, CDK5 and ABL1 enzyme substrate 1, 40S ribosomal protein S14, phosphatidylinositol 4-phosphate 5-kinase type 1 beta, cyclin-dependent kinase 16, SAP domain-containing ribonucleoprotein, protein NDRG1, WAS protein family homolog 1, interferon regulatory factor 4, DNA-directed DNA / RNA polymerase mu, actin-like protein 6A, dedicator of cytokinesis protein 4, protein-free homolog, telomere-associated protein RIF1, Ras-binding domain-containing protein 1, cytochrome P450 2J2, protein scribble homolog, proheparin-binding EGF-like growth factor, cytosolic acyl-coenzyme A thioester hydrolase, cohesin subunit SA-1, myomegalin, twinfilin-1, stromal interaction molecule 1, putative U3 small nuclear RNA-associated protein 11, centromere-associated protein E, zinc finger C3H1 domain-containing protein, EF-hand domain-containing protein D1, keratin, type II cytoskeleton 8, retrotransposon-derived protein PEG10, cyclin-dependent kinase 2, UBX domain-containing protein 11, Pecanex-like protein Protein 3, Rho guanine nucleotide exchange factor 3, ADP-ribosylation factor-like protein 4C, ribosome biogenesis protein BOP1, KDEL motif-containing protein 2, chromosomal protein structural maintenance 5, La-related protein 4B, acid ceramidase, proteasome assembly chaperone 1, radixin, retinoblastoma binding protein 5, forkhead box protein N2, rRNA processing protein UTP23 homolog, Src kinase-related phosphoprotein 2, volume-regulatory anion channel subunit LRRC8C, acyl-CoA dehydrogenase family member 9, mitochondria, beta-synuclein,Short coiled-coil protein, collagen alpha-2(VI) chain, ubinuclein-2, plasma membrane vesicle-associated protein, mitofusin-2, small integral membrane protein 20, stromal interaction molecule 2, threonylcarbamoyladenosine tRNA methylthiotransferase, alpha-soluble NSF attachment protein, putative E3 ubiquitin protein ligase UBR7, BRCA1-related ATM activator 1, group XIIA secreted phospholipase A2, transcription factor 20, potassium channel subfamily K member 4, casein kinase I isoform alpha, bombesin receptor-activating protein C6orf89, peripheral plasma membrane protein CASK, proline-rich protein PRCC, serine / threonine protein kinase SIK2, host cell factor 1, transducin-like enhancer protein 4, and biogenesis of lysosome-related organelle complex 1 subunit 6 6), queuin tRNA ribosyltransferase subunit QTRTD1, RNA-binding protein 33, leucine-rich repeat-containing protein 59, transcription factor Sp3, eukaryotic initiation factor 4A-III, E3 ubiquitin protein ligase RNF181, mediator of RNA polymerase II transcription subunit 7, transcription elongation factor SPT4, homeobox protein TGIF2, carnitine O-palmitoyltransferase 1, hepatic isoform, cGMP-inhibitory 3',5'-cyclic phosphodiesterase B, polymerase delta-interacting protein 3, Runt-related transcription factor 2 , THUMP domain-containing protein 3, serpin B6, interleukin 32, sodium-binding neutral amino acid transporter 1, nucleoside diphosphate kinase A, cytochrome b, putative uncharacterized protein ZNF436-AS1, beta-1-syntrophin, mitotic-spindle assembly protein 2A, calcium / calmodulin-dependent protein kinase II inhibitor 1, necdin, FERM domain-containing protein 8, serine / threonine protein phosphatase 2A catalytic subunit beta isoform, transcription factor 4, SHC converting protein 4, dedicator of cytokinesis protein 8,Ankyrin repeat domain-containing protein 54, transcription factor jun-B, periodic tryptophan protein 2 homolog, RUS1 family protein C16orf58, pterin-4-alpha-carbinolamine dehydratase, tyrosine protein phosphatase non-receptor type 13, chloride intracellular channel protein 5, PHD finger protein 20-like protein 1, 55 kDa erythrocyte membrane protein, tetratricopeptide repeat protein 4, roundabout homolog 1 1), putative methyltransferase NSUN3, Toll-like receptor 9, E3 ubiquitin protein ligase DTX3L, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1, GRB2-related adaptor protein, fructosamine-3-kinase, TATA element regulator, nuclear autoantigen Sp-100, solute carrier family 41 member 3, putative polycomb group protein ASXL2, protein ZGRF1, transmembrane emp24 domain-containing protein 5, E3 ubiquitin protein ligase RNF31, B cell receptor-associated protein 29, mRNA cap guanine N7 methyltransferase, uromodulin Phosphorin, signal transducer CD24, integrin alpha-6, NF-kappa-B essential modulator, kinesin-like protein KIFC1, translation machinery-associated protein 16, valine-tRNA ligase, COMM domain-containing protein 9, 28S ribosomal protein S21, mitochondria, Kalirin, prostaglandin F2 receptor negative regulator, BTB / POZ domain-containing protein 2, Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase, tRNA-dihydrouridine(20) synthase [NAD(P)+]-like, surfate locus protein 6, Rho GTPase-activating protein 19, eukaryotic translation initiation factor 4E, CXC motif chemokine 14, phagocytosis and cell motility protein 1, collagen alpha-1(XVIII) chain, isochorismatase domain-containing protein 2, coatomer subunit gamma-2, DNA-directed RNA polymerase III subunit RPC1, kazurin,Synaptojanin 2-binding protein, 85 kDa centrosomal protein, transmembrane protein 69, lariat debranching enzyme, receptor activity-modifying protein 2, F-box-only protein 32, transcription cofactor vestige-like protein 4, SH3 domain-binding protein 1, epsin-2, mitogen-activated protein kinase 3, lagulator complex protein LAMTOR2, mitogen-activated protein kinase 9, adipocyte plasma membrane-associated protein, [pyruvate dehydrogenase [acetyltransferase]]-phosphatase 1, mitochondrial, 28S ribosomal protein S12, mitochondrial, WD repeat and FYVE domain-containing protein 1, protein disulfide isomerase A4, protein DEPP, antigenic peptide transporter 2, CDC42 small effector protein 1, cyclin-dependent kinase 13, MICOS complex subunit MIC10, nicastrin, protein FAM73A, complement C1q subcomponent subunit C, 28S ribosomal protein S7, mitochondrial, serine / threonine protein kinase TAO1, Ras GTPase-activating protein 3, protein LDOC1L, cytosolic 10-formyltetrahydrofolate dehydrogenase, smoothelin, WW domain-binding protein 5, phosphatidylinositide phosphatase SAC1, 39S ribosomal protein L3, mitochondrial, inositol triphosphate 3-kinase B, erythrocyte band 7 integral membrane protein, solute carrier family 35 member E1, putative 28S rRNA (cytosine(4447)-C(5))-methyltransferase, Y-box binding protein 3, proline, glutamic acid, and leucine-rich protein 1, HCLS1-binding protein 3, ubiquitin carboxyl-terminal hydrolase 37, protein-L-isoaspartate (D-aspartic acid) O-methyltransferase, transcriptional activator Myb, abnormal spindle-like microcephaly-associated protein, exportin-4, GMP reductase 1, sperm-associated antigen 7, tyrosine protein kinase Fer, coronin-1B, acidic leucine-rich nuclear phosphoprotein 32 family member B, Schlafen family member 5, macrophage erythroblast adhesion factor, histone acetyltransferase KAT2A,Mitotic spindle assembly checkpoint protein MAD2B, RecQ-mediated genome instability protein 1, upregulator of cell proliferation, nucleoside diphosphate kinase, c-myc promoter binding protein, molybdate anion transporter, integrator complex subunit 5, 170 kDa centrosomal protein, protein CASC5, ephrin A4, tumor suppressor p53-binding protein 1, proteasome ATPase-associated factor 1, gephyrin, helicase SKI2W, pleckstrin homology domain-containing family G member 2, serine / threonine protein kinase receptor R3, AP-5 complex subunit mu-1, nuclear receptor subfamily 1 group D member 1, DnaJ homolog subfamily B member 2, merlin, ashwin, transmembrane protein 176A, synaptotagmin-like protein 2, serine / threonine protein kinase RIO2, AP-3 complex subunit beta-1, forkhead box protein O1, protein STON1-GTF2A1L, lysine-specific demethylase 7A, inactive phospholipase C-like protein 2, transcription Factor MafG, protein TBRG4, nesprin-1, type I inositol 1,4,5-triphosphate 5-phosphatase, discus large homolog 3, long-chain fatty acid CoA ligase 5, trafficking protein particle complex subunit 1, bromodomain testis-specific protein, heterochromatin protein 1-binding protein 3, histone H1.3, malectin, glyoxalase domain-containing protein 4, SRSF protein kinase 2 twinfilin-2, ATPase WRNIP1, transgelin, echinoderm microtubule-associated protein-like 3 , histone deacetylase complex subunit SAP18, RE1 silencing transcription factor, protein tyrosine phosphatase type IVA1, phospholipase D3, microfilament-associated protein 1, putative protein arginine N-methyltransferase 9, protein NYNRIN, NADH-cytochrome b5 reductase 1, centrosomal protein POC5, protrudin, transcription initiation factor TFIID subunit 8, motile sperm domain-containing protein 1, splicing factor, arginine / serine-rich 19,BTB / POZ domain-containing adaptor for CUL3-mediated RhoA degradation protein 2, centrin-specific protease 3, interferon regulatory factor 1, 40S ribosomal protein S4, Y isoform 2, transmembrane protein 147, transcriptional regulator Kaiso, HCG2043421, isoform CRA_c, WD repeat-containing protein 78, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, , aldehyde dehydrogenase family 16 member A1, protein phosphatase 1D, caspase-1, CMP-N-acetylneuraminic acid-beta-galactosamide-alpha-2,3-sialyltransferase 1, putative 40S ribosomal protein S10-like, protein DENND6A, N-glycosylase / DNA lyase, Kelch-like protein 5, RNA-binding protein 40, major prion protein, fibroblast growth factor receptor substrate 2, fragile X mental retardation protein 1, signal recognition particle 14 kDa protein, sarcolemmal membrane-associated protein, 5-formyltetrahydrofolate cycloligase, 2',5'-phosphodiesterase 12, receptor tyrosine-protein phosphatase U, translocon-associated protein subunit gamma, guanine nucleotide-binding protein-like 3, Ran-binding protein 6, transcription factor Sp4, histone deacetylase complex subunit SAP13 0, adaptor protein CIKS, PDZ and LIM domain protein 5, ankyrin repeat domain-containing protein 40, uroporphyrinogen decarboxylase, DNA repair protein RAD51 homolog 3, CGG triplet repeat-binding protein 1, ubiquitin carboxyl-terminal hydrolase BAP1, ATP-dependent DNA helicase Q1, sorting nexin-8, syntaxin-binding protein 6, protein syndesmos, mitogen-activated protein kinase kinase kinase 6, gametogen-binding protein 2, ATP-dependent phosphofructokinase 6, muscle type 6, ADP-ribosylation factor-like protein 6-interacting protein 1, protein dpy-30 homolog, Ras-like protein family member 11A, core histone macro-H2A.1, vacuolar protein sorting-associated protein 16 homolog, ER luminal protein retention receptor 2, ubiquitin-conjugating enzyme E2 L3, phosphatidic acid cytidyltransferase 1, putative oxidoreductase GLYR1, 39S ribosomal protein L37, mitochondria, HLA class II histocompatibility antigen, DQ beta 1 chain, mitogen-activated protein kinase 14, mitogen-activated protein kinase 7, endoplasmic reticulum lectin 1, Rho GTPase-activating protein 17, EP300-interacting inhibitor of differentiation 1, codanin-1,Tetratricopeptide repeat protein 19, mitochondrial, high-affinity cationic amino acid transporter 1, protein strawberry notch homolog 2, lavankyrin-5, HEAT repeat-containing protein 6, mitochondrial antiviral signaling protein, liprin-alpha-1, chromodomain helicase-DNA binding protein 9, Ras-specific guanine nucleotide releasing factor RalGPS2, transmembrane 9 superfamily member 1, dipeptidyl peptidase 2, lysophosphatidylcholine acyltransferase 1, E1A-binding protein p400, DNA fragmentation factor subunit alpha, DNA mismatch repair protein Mlh1, receptor-interacting serine / threonine protein kinase 4, alpha tubulin N-acetyltransferase 1, HLA class I histocompatibility antigen, B-40 alpha chain, RILP-like protein 1, aminopeptidase B, protein fem-1 homolog A, DNA polymerase alpha catalytic subunit, protein DGCR6L, histone deacetylase 10, DENN domain-containing protein 4B, transmembrane protein 102, cell differentiation protein RCD1 homolog, GSK3-beta interacting protein, multiple inositol polyphosphate phosphatase 1, THAP domain-containing protein 11, synaptosomal-associated protein 29, inversin, small integral membrane protein 10, kinesin light chain 1, tRNA splicing endonuclease subunit Sen2, putative phospholipase B-like 2, AP-1 complex subunit gamma-1, E3 ubiquitin protein ligase RFWD2, integrin alpha-X, chitobiosyldiphosphodolichol beta-mannosyltransferase , tripartite motif-containing protein 44, histone H1.4, liprin-beta-1, zinc finger HIT domain-containing protein 2, RELT-like protein 1, rhotekin, long-chain fatty acid transport protein 1, coiled-coil domain-containing protein 50, pumilio homolog 2, alpha actinin-1, vacuolar protein sorting-related protein 54, Erlin-1, ubiquitin carboxyl-terminal hydrolase 28, echinoderm microtubule-associated protein-like 5, GRB2-associated binding protein 1, protein BANP, DNA excision repair protein ERCC-1,Zinc finger and BTB domain-containing protein 17, autophagy-related protein 16-1, segment polarity protein dishevelled homolog DVL-2, GRIP1-related protein 1, circadian clock protein PASD1, cyclin J-like protein, tristetraprolin, and Ral GTPase-activating protein subunit alpha-1, DENN domain-containing protein 5B, caspase recruitment domain-containing protein 19, eukaryotic translation initiation factor 4 gamma 2, phospholipase DDHD1, major facilitator superfamily domain-containing protein 1, beta-glucuronidase, putative protein PLEKHA9, putative ATP-dependent RNA helicase DDX59, putative histone H2B type 2-D, osteoporosis-associated transmembrane protein 1, structure-specific endonuclease subunit SLX1, nicalin, E3 ubiquitin protein ligase XIAP, rhomboid domain-containing protein 2, telomere length regulatory protein TEL2 homolog, leucine-rich repeat serine / threonine protein kinase 2, U3 small nucleolar RNA-associated protein 18 homolog, CAP-G ly domain-containing linker protein 1, autophagy-related protein 13, WD repeat and FYVE domain-containing protein 3, transcription initiation factor TFIID subunit 4B, phosphatidylinositol N-acetylglucosaminyltransferase subunit H, adiponectin receptor protein 2, protein GPR107, tumor protein p53-inducible protein 13, p53 apoptosis-stimulating protein 2, Kelch domain-containing protein 3, leucine-rich repeat and calponin homology domain-containing protein 1, vascular endothelial growth factor receptor 1, transcription factor E2-alpha, pre-mRNA processing factor 17, leupaxin, transmembrane protein 2, huntingtin-interacting protein 1, NIPA-like protein 3, glucosamine-6-phosphate isomerase 2, U6 snRNA-associated Sm-like protein LSm8, copper chaperone of superoxide dismutase, major facilitator superfamily domain-containing protein 8, integrator complex subunit 7,Cytoplasmic dynein 1 light intermediate chain 2, protein angel homolog 1, protein cramped-like, transmembrane protein 261, apoptosis-resistant E3 ubiquitin protein ligase 1, endonuclease G, mitochondria, something about silencing protein 10, calpain-7, putative ATP-dependent RNA helicase DDX60, KAT8-regulated NSL complex subunit 1, protein NPAT, Rab3 GTPase-activating protein catalytic subunit, transmembrane protein 223, tRNA wibtosin synthase protein 2 homolog, T-complex protein 11-like protein 2, TATA box-binding protein-associated factor RNA polymerase I subunit B, Rab-like protein 2A, inactive ubiquitin carboxyl-terminal hydrolase 54, inner nuclear membrane protein Man1, ribosomal protein S6 kinase alpha-4, ligand for Numb protein X 2, DDB1 and CUL4-associated factor 16, HCG2044777, TELO2-interacting protein 2, bromodomain-containing protein 9, zinc finger protein 644, dual specificity protein phosphatase 10, Tax1-binding protein 1, THAP domain-containing protein 4, DNA topoisomerase I, mitochondria, NFATC2-interacting protein, ATPase family AAA domain-containing protein 1, protein hook homolog 1, polypeptide N-acetylgalactosaminyltransferase 18, kinesin-like protein KIF1C, trafficking protein particle complex subunit 11, cytochrome P450 4V2, NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondria, cAMP-dependent protein kinase type II-alpha regulatory subunit, transmembrane protein 245, acetyl-CoA acetyltransferase, mitochondria, AP-1 complex subunit sigma-1A, mRNA export factor, SKI oncogene, breast cancer type 2 susceptibility protein, E3 UFM1-protein ligase 1, ribonuclease H2 subunit B, beta-secretase 2, growth arrest-specific protein 7,Lethal(2) giant larvae protein homolog 2, activating signal cointegrator 1 complex subunit 3, zinc finger protein 532, DNA-directed RNA polymerase II subunit RPB11-a, ubiquitin / ISG15-conjugating enzyme E2 L6, Kelch-like protein 12, tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like, activating molecule for BECN1-regulated autophagy protein 1, angiomotin-like protein 1, pleckstrin homology domain-containing family A member 4, liprin-alpha-3, fiber bundle and elongation protein zeta-2,5'-nucleotidase domain-containing protein 3, growth arrest-specific protein 8, SLIT-ROBO Rho GTPase-activating protein 2, DNA dC->dU editing enzyme APOBEC-3A, N-acetylgalactosamine kinase, and U6 snRNA-associated Sm-like protein LSm4, keratinocyte-associated transmembrane protein 2, E3 ubiquitin protein ligase UBR1, riboflavin kinase, TFIIH basal transcription factor complex helicase XPB subunit, GPN-loop GTPase 3, nitrogen permease regulator 3-like protein, SH3KBP1-binding protein 1, serine / threonine protein phosphatase 4 regulatory subunit 3B, nonconventional myosin XVIIIa, Ras GTPase-activating-like protein IQGAP3, proteins TRIM6-TRIM34, calponin-2, developmentally regulated GTP-binding protein 1, transcription initiation factor TFIID subunit 1, zinc finger BED domain-containing protein 4, ubiquitin-like modifier activating enzyme 7, protein C12orf4, prefoldin subunit 1, phosphatidic acid phosphatase LPIN1, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, mitochondrial fission regulator 1, palladin, forkhead box protein J3, tyrosine-protein phosphatase non-receptor type 12, phospholipase A1 member A, eye abscent homolog 2, dual specificity protein phosphatase 6, COMM domain-containing protein 8, nuclear factor NF-kappa-B p105 subunitKetosamine-3-kinase, E3 ubiquitin-protein ligase RLIM, cyclin-L2, WD repeat domain phosphoinositide interacting protein 4, DDB1 and CUL4-associated factor 4-like protein 1, Partitioning defective 3 homolog, 3-ketodihydrosphingosine reductase, upstream binding protein, Protein 1, xyloside xylosyltransferase 1, suppressor APC domain-containing protein 2, translocon-associated protein subunit beta, vacuolar protein sorting-associated protein 33B, putative inactive glycosyltransferase 25 family member 3, HMG domain-containing protein 4, protein orai-3, copine-3, myeloid-derived growth factor, BTB / POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 1), calcium-independent phospholipase A2-gamma, sperm-specific antigen 2, glycerol-3-phosphate acyltransferase 1, mitochondrial replication initiator 1, uncharacterized protein C15orf39, uncharacterized protein C5orf34, FAD synthase, inhibitor of Bruton's tyrosine kinase, cell growth regulatory nucleolar protein, EF-hand domain-containing protein 1, centrosome-associated protein CEP250, SH3 domain tetratricopeptide repeat-containing protein 1, Kelch-like protein 21, cullin-9, optineurin, Kelch domain-containing protein 10, cation channel sperm-associated protein 2, solute carrier family 35 member C2 , carboxypeptidase D, peroxisome biogenesis factor 3, kinesin-like protein KIF3A, lysosomal trafficking regulator, uncharacterized aarF domain-containing protein kinase 2, transportin-3, mediator of RNA polymerase II transcription subunit 24, CAP-Gly domain-containing linker protein 2, solute carrier family 35 member E4, sestrin-3, bromodomain adjacent to zinc finger domain protein 1A, dehydrogenase / reductase SDR family member 1, cyclin-dependent-like kinase 5, heat shock factor protein 2, serine / threonine protein kinase TBK1, ubiquitin-binding factor E4 B, band 4.1-like protein 3, ADNP homeobox protein 2, ubiquitin carboxyl-terminal hydrolase 6, mediator of DNA damage checkpoint protein 1, mitochondrial fission factor, PDZ domain-containing protein GIPC1,Serine incorporator 1, nectin 2, phosphopantothenate cysteine ​​ligase, paraspeckle component 1, tumor necrosis factor receptor superfamily member 6, vacuolar protein sorting-associated protein 29, EMILIN-2, ubiquitin carboxyl-terminal hydrolase 33, mediator of RNA polymerase II transcription subunit 14, histone-lysine N-methyltransferase 2B, coronin, signal-induced growth-associated protein 1, 2-hydroxyacyl-CoA lyase 1, Kelch-like protein 22, vacuolar protein sorting-associated protein 11 homolog, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, acylglycerol kinase, mitochondria, transmembrane protein 9B, insulin-like growth factor 2 mRNA-binding protein 1, tartrate-resistant acid phosphatase type 5, Kelch-like protein 18, glycogen phosphorylase, liver type, protein Mis18-beta, guanine nucleotide-binding protein G(i) subunit alpha-1, Disheveled-associated activator of morphogenesis 2 2), protein VAC14 homolog, ubiquitin-like protein 4A, vesicle trafficking protein SEC22b, zinc finger CCCH-type antiviral protein 1, phosphatidylinositol N-acetylglucosaminyltransferase subunit A, coiled-coil domain-containing protein 84, vesicle-associated membrane protein 4, UPF0606 protein KIAA1549L, phosphatidylglycerophosphatase and protein tyrosine phosphatase 1, uncharacterized protein C11orf24, 60S ribosomal protein L32, EF-hand calcium-binding domain-containing protein 7, glucose-fructose oxidoreductase domain-containing protein 2, nucleolar protein 6, NAD kinase, methyltransferase-like protein 9, GTP-binding protein 2, protocadherin beta-6, myotubularin-related protein 4, serine palmitoyltransferase small subunit A, G-patch domain-containing protein 11, GRB2-related binding protein 2,Copper-transporting ATPase 1, coiled-coil and C2 domain-containing protein 2A, helicase ARIP4, uncharacterized protein C20orf144, gamma-soluble NSF attachment protein, lysine-specific demethylase 6A, protein S100-A6, collagen alpha-2(VIII) chain, ephrin type B receptor 1, Fer-1-like protein 5, molybdenum cofactor sulfolase, cysteine-rich protein 2, interferon-inducible protein 2 with tetratricopeptide repeats, Fas-binding factor 1, IQ motif and SEC7 domain containing protein 2, beta-secretase 1, GDNF family receptor alpha-1, H / ACA ribonucleoprotein complex subunit 2, Rho guanine nucleotide exchange factor 17, uncharacterized protein C2orf15, nesprin-3, ankyrin repeat domain-containing protein 35, putative ATP-dependent RNA helicase DDX53, DNA-binding protein RFX6, BTB / POZ domain-containing protein KCTD7, Fanconi anemia group M protein, collagen alpha-4(IV) chain, complement C4-A, collagen alpha-1(X) IX) chain, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2, kinesin-like protein KIF27, meprin A subunit beta, F-box / LRR repeat protein 4, PHD finger protein 14, arylsulfatase E, NACHT, LRR and PYD domain-containing protein 9, Kelch-like protein 2, protein RER1, L-lactate dehydrogenase A-like 6B, diacylglycerol O-acyltransferase 2, PWWP domain-containing protein 2B, DNA mismatch repair protein Mlh3 , cathepsin K, synaptojanin-1, zinc finger MYND domain-containing protein 15, histone H2A type 2-A, D-dopachrome decarboxylase, FAST kinase domain-containing protein 1, F-box-only protein 41, threonine synthase-like 1, beta-1,4-galactosyltransferase 7, usherin, nucleoside diphosphate kinase B, endoplasmic reticulum aminopeptidase 2, Wiskott-Aldrich syndrome protein, cartilage intermediate lamina protein 1, putative phosphoglycerate mutase 4, tumor protein D52,Histidine protein methyltransferase 1 homolog, glutaredoxin-2, mitochondria, polycystin-1, cilium- and flagella-associated protein 52, oxysterol-binding protein 2, UV excision repair protein RAD23 homolog B, protein Boule-like, beta-1,3-galactosyltransferase 6, sodium-binding monocarboxylate transporter 2, rabenosin-5, leucine-rich repeat-containing protein 28, NUAK family SNF1-like kinase 2, laminin subunit alpha-4, otoferlin, procollagen lysine, 2-oxoglutarate 5-dioxygenase 1, galectin-1, ovochymase-1, envoplakin, neuron navigator 2, VIP peptide, activin receptor type 2A, EF-hand serine / threonine protein phosphatase 1, Kin of IRRE-like protein 3 3), ankyrin repeat domain-containing protein 26, microsomal glutathione S-transferase 1, gamma enolase, matrix remodeling-related protein 5, HMG domain-containing protein 3, selenide, water dikinase 2, transmembrane glycoprotein NMB, cytochrome b-245 light chain, transcription factor 7-like 2, tumor protein p63-regulated gene 1-like protein, transmembrane protein 141, protein FAM188B, protein TANC1, 5-oxoprolinase, tryptophan tRNA ligase, cytoplasmic, leishmanolysin-like peptidase, kinesin-like protein KIF7, 40S ribosomal protein S12, anthrax toxin receptor 1, and Cutin-related protein 2 / 3 complex subunit 1A, nicotinic acid nucleotide pyrophosphorylase [carboxylation], Caskin-2, protein Wnt-5a, dehydrogenase / reductase SDR family member 4, fatty acid desaturase 1, RalBP1-related Eps domain-containing protein 1, cadherin-5, mitogen-activated protein kinase kinase kinase MLT, transcription initiation protein SPT3 homolog, HEAT repeat-containing protein 5A, solute carrier family 26 member 6, CD109 antigen, stress-inducible phosphoprotein 1, nuclear receptor coactivator 7, liprin-alpha-4, mesoderm-induced early response protein 1,Kynurenine-oxoglutarate transaminase 3, leucine zipper-like transcriptional regulator 1, ubiquitin-like conjugated ATG3, protein shisa-5, cell adhesion molecule-associated / downregulated oncogene, breast cancer anti-estrogen resistance protein 3, phosphoacetylglucosamine mutase, Ras-related protein Rab-14, glutamate receptor ionotropic, kainate 2, DNA-directed RNA polymerase III subunit RPC3, enhancer of polycomb homolog 1, nuclear protein 1, melanoma-associated antigen 11, inositol polyphosphate multikinase, sorting nexin 18, poly[ADP-ribose] polymerase 12, ubiquitin-conjugating enzyme E2 K, leucine-rich repeat and immunoglobulin-like domain protein 2, trifunctional enzyme subunit beta, mitochondrial, cytoplasmic dynein 2 heavy chain 1, thimet oligopeptidase, mTOR regulatory-related protein, protein FAM83H, DDB1 and CUL4-associated factor 12, creatine kinase M type, nestin, ADP-ribosylation factor-binding protein GGA1, DDRGK domain-containing protein 1, laminin subunit alpha-1, upstream stimulatory factor 1, reticulocalvin 3, low-density lipoprotein receptor-related protein 4, PR domain zinc finger protein 10, glutathione S-transferase Mu3, ribosomal protein S6 kinase alpha-5, protein CLEC16A, zinc transporter SLC39A7, armadillo repeat-containing 8, isoform CRA_g, uncharacterized protein KIAA0355, caseinolytic peptidase B protein homolog, hypoxanthine-guanine phosphoribosyltransferase, receptor tyrosine-protein phosphatase F, rhofilin-2, E3 ubiquitin-protein ligase Arcadia, dedicator of cytokinesis protein 5, dynein heavy chain 14, axoneme, U5 small nuclear ribonucleoprotein 40 kDa protein, progesterone-induced blocking factor 1, vesicle-associated membrane protein-related protein A, switch-related protein 70, prolow-density lipoprotein receptor-related protein 1, noelin,D-3-phosphoglycerate dehydrogenase, serine / threonine protein kinase 24, serine protease HTRA1, 39S ribosomal protein L12, mitochondria, peptidyl-prolyl cis-trans isomerase FKBP9, E3 ubiquitin-protein ligase TRIM21, Wee1-like protein, Protein kinase, hydroxyacylglutathione hydrolase, mitochondria, solute carrier family 12 member 4, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, USP6 N-terminal-like protein, collagen alpha-1(XV) chain, nuclear fragile X mental retardation interacting protein 2, protein unc-119 homolog B, exocyst complex component 6B, aminoacylase-1, kelch domain-containing protein 7B, pre-rRNA processing protein FTSJ3, ryanodine receptor 1, nucleobindin-1, striatin-3, serine / threonine protein kinase ULK4, GTP-binding protein Rheb, putative E3 ubiquitin protein ligase HERC3, dedicator of cytokinesis protein 1, proline-rich protein 11, sister chromatid cohesion protein PDS5 homolog B, breast cancer anti-estrogen resistance protein 1, vitamin K-dependent protein S, POZ-, AT-hook, and zinc finger-containing protein 1, putative global transcriptional activator SNF2L1, hepatocyte growth factor receptor, leucine-rich repeat-containing protein 42, AMP deaminase 2, protein phosphatase Thrombomodulin ATP homolog 3, serine / threonine protein kinase PLK3, BTB / POZ domain-containing protein 3, general transcription factor IIF subunit 1, protein SOGA1, serine / threonine protein phosphatase 4 catalytic subunit, zinc finger protein 3, neuroligin, mitochondria, T-box transcription factor TBX3, Bardet-Biedl syndrome 10 protein, inositol triphosphate 3-kinase C, serine / threonine protein phosphatase 5, phospholipase DDHD2, zinc finger protein 530, phospholysine phosphohistidine inorganic pyrophosphate phosphatase, SPRY domain-containing SOCS box protein 1, supervillin, UDP-N-acetylglucosamine / UDP-glucose / GDP-mannose transporter, complement decay-accelerating factor, LIM and calponin homology domain-containing protein 1, lysosomal Pro-X carboxypeptidase, putative RNA polymerase II subunit B1 CTD phosphatase RPAP2, heat shock 70 kDa protein 13,Alpha / beta hydrolase domain-containing protein 14B, non-conventional myosin X, mimitin, mitochondria, protein TALPID3, 63 kDa centrosomal protein, very long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3, HAUS augmin-like complex subunit 6, neural cell adhesion molecule L1, oxysterol-binding protein-associated protein 1, caspase recruitment domain-containing protein 8, Ras-related protein Rap-2c, sorting nexin-30, serine / threonine protein kinase D3, progressive ankylosis protein homolog, bleomycin hydrolase, trafficking protein particle complex subunit 2, pyruvate carboxylase, mitochondria, peroxisome proliferator-activated receptor gamma coactivator 1 alpha, cadherin EGF LAG 7-pass G-type receptor 2, cytokinesis protein dedicator 9, c-Jun amino-terminal kinase interacting protein 4, E3 ubiquitin protein ligase SHPRH, alpha-mannosidase 2x, H / ACA ribonucleoprotein complex subunit 1, zinc finger protein 503, tubulin polyglutamylase TTLL4, oxysterol-binding protein-related protein 10, origin recognition complex subunit 5, serine / threonine protein kinase PLK4, discus large homolog 5, H / ACA ribonucleoprotein complex non-core subunit NAF1, prolyl 3-hydroxylase 1, protein FAM46B, nuclear factor type 1X, multiple PDZ domain protein, serine / threonine protein kinase SIK3, ribonuclease P protein subunit p21, serine / threonine protein kinase MRCK beta, serine / threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, snRNA activator protein complex subunit 1, Rab protein geranylgeranyltransferase component A1, cystine / glutamate transporter, ER degradation-promoting alpha mannosidase-like protein 3, RNA pseudouridylate synthase domain-containing protein 2, DENN domain-containing protein 1B, trimethylguanosine synthase, catechol O-methyltransferase,E3 ubiquitin protein ligase DZIP3, myotubularin-related protein 13, epoxide hydrolase 1, RNA-binding motif protein, X-linked-like 2, tyrosine protein phosphatase non-receptor type 9, cell cycle checkpoint control protein RAD9A, UHRF1-binding protein 1-like, plasma membrane calcium-transporting ATPase 4, aminoacyl-tRNA synthase complex-interacting multifunctional protein 1, neuronal Wiskott-Aldrich syndrome protein, collagen alpha-1(VII) chain, Kelch repeat and BTB domain-containing protein 2, protein FAM63A, RNA-binding protein with multiple splicing 2, discoidin domain-containing receptor 2, actin filament-associated protein 1, protein Smaug homolog 1, serum paraoxonase / arylesterase 2, ankyrin repeat and BTB / POZ domain-containing protein 2, zinc-binding alcohol dehydrogenase domain-containing protein 2, serine / threonine protein kinase 3, actin-associated protein 10, lipoma-preferred partner partner), zinc finger protein RFP, very long-chain enoyl-CoA reductase, elongation protein 4 homolog (S. cerevisiae), isoform CRA_b, dual specificity protein phosphatase 4, anoctamin-1, actin-binding LIM protein 3, kelch-like protein 9, cytoplasmic aconitate hydratase, protein FAM178B, cell cycle control protein 50A, tRNA wibtosin synthesis protein 4, cholinephosphotransferase 1, glycogen synthase kinase-3 alpha, tectoni ck-3, paired amphipathic helix protein Sin3b, ATP-binding cassette subfamily D member 3, CCR4-NOT transcription complex subunit 4, minichromosome maintenance complex-binding protein, integral membrane protein 2C, protein C-ets-2, interferon-inducible 35 kDa protein, RNA-binding protein NOB1, selenocysteine ​​insertion sequence-binding protein 2, enoyl-CoA delta isomerase 2, mitochondrial, receptor tyrosine protein kinase erbB-3, division-defective 3 homolog B, F-box-only protein 42,Brain-specific angiogenesis inhibitor 1-related protein 2, hemoglobin subunit gamma 2, zinc transporter 6, La-related protein 4, zinc transporter 7, ribonuclease P protein subunit p30, tensin 2, volume-regulatory anion channel subunit LRRC8E, kinesin-like protein KIF3B, cytochrome c oxidase assembly protein COX11, mitochondria, tripartite motif-containing protein 47, monocarboxylate transporter 1, DDB1 and CUL4-related factor 4, kinesin-like protein KIF1A, kinesin-like protein KIF13A, ATP synthase F(0) complex subunit B1, mitochondria, LIM domain-containing protein Ajuba ajuba), UDP-glucose 6-dehydrogenase, transcriptional enhancer factor TEF-3, Mid1-interacting protein 1, lipase maturation factor 2, ganglioside-induced differentiation-associated protein 2, BAG family molecular chaperone regulator 4, InaD-like protein, RNA-binding protein fox-1 homolog 2, protein TANC2, putative E3 ubiquitin-protein ligase HECTD2, medium-chain-specific acyl-CoA dehydrogenase, mitochondria, prenylcysteine ​​oxidase 1, interferon alpha-inducible protein 27-like protein 2, RNA-binding protein 38, ephrin-A1, glycine dehydrogenase (decarboxylation), mitochondria, protein FAM50A, ELM2, and SANT domain-containing protein Protein 1, UPF0668 protein C10orf76, synaptonemal complex protein SC65, 5'-AMP-activated protein kinase catalytic subunit alpha-1, peroxisome assembly protein 26, thioredoxin domain-containing protein 5, cell cycle and apoptosis regulator protein 2, X-box binding protein 1, protein YIF1A, PAB-dependent poly(A)-specific ribonuclease subunit PAN2, methionine-R-sulfoxide reductase B1, calcineurin-binding protein CABIN-1, protein RTF2 homolog, endoplasmic reticulum-Golgi intermediate compartment protein 2, general transcription factor 3C polypeptide 3, N-acylneuraminic acid cytidylyltransferase,Zinc finger protein ZXDC, PRKCA binding protein, talin-2, SURP and G-patch domain-containing protein 2, kinesin-1 heavy chain, syntaxin-8, galectin-3 binding protein, ankyrin repeat and zinc finger domain-containing protein 1, E3 ubiquitin protein ligase NEURL1B, transcription and mRNA export factor ENY2, V-type proton ATPase 21 kDa proteolipid subunit, putative RNA-binding protein 19, selenoprotein O, zinc finger protein 622, origin recognition complex subunit 3, serine / threonine protein phosphatase 6 regulatory ankyrin repeat subunit A, 39S ribosomal protein L22, mitochondria, chromosome transmission fidelity protein 8 homolog isoform 2, zinc finger protein 574, and ubiquitin-conjugating enzyme E2 T, anthrax toxin receptor 2, cilium- and flagella-associated protein 58, mitogen-activated protein kinase-binding protein 1, glucosamine 6-phosphate N-acetyltransferase, UPF0472 protein C16orf72, NAD(P) transhydrogenase, mitochondria, E3 ubiquitin protein ligase RNF220, collagen alpha-1(XII) chain, serine / threonine protein kinase OSR1, inositol pentakisphosphate 2-kinase, general transcription factor IIH subunit 2, polycomb group RING finger protein 6, isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, protein MMS22-like, HAUS augmin-like complex subunit 7, PIN2 / TERF1-interacting telomerase inhibitor 1, homeobox protein Hox-A13, tubby-related protein 4, Golgi apparatus membrane protein TVP23 homolog B, phosphoribosyl pyrophosphate synthase-related protein 1, protein phosphatase methylesterase 1, uncharacterized aarF domain-containing protein kinase 5, protein canopy homolog 4, zinc transporter ZIP3, L-xylulose reductase, protein S100-A16, zinc finger SWIM domain-containing protein 8,Charged multivesicular body protein 3, aspartyl aminopeptidase, TSC22 domain family protein 4,5'-AMP-activated protein kinase subunit gamma-1, CD99 antigen-like protein 2, CD81 antigen, inositol 1,4,5-trisphosphate receptor-interacting protein, ankyrin-2, leucine-rich repeat protein SHOC-2, angiomotin-like protein, Protein 2, zinc finger protein 580, proteasome subunit beta type-10, torsin-1A interacting protein 2, 95 kDa centrosome protein, securin, 26S protease regulatory subunit 8, nucleoporin NUP53, nicotinamide / nicotinic acid mononucleotide adenylyltransferase 1, mediator of RNA polymerase II transcription subunit 13-like protein, protein FAM172A, N-acetyl-D-glucosamine kinase, Hsp70-binding protein 1, ribosomal RNA processing protein 7 homolog A, methylmalonic aciduria and homocystinuria type D protein, mitochondrial, glycerol-3-phosphate dehydrogenase 1-like protein, 3-ketoacyl-CoA thiolase, mitochondrial, COMM domain-containing protein 6, replication protein A 14kDa subunit, peptidyl-prolyl cis-trans isomerase CWC27 homolog, uncharacterized protein C16orf45, NF-kappa-B inhibitor-interacting Ras-like protein 1, FRAS1-related extracellular matrix protein 2, semaphorin-3C, maturin, U11 / U12 small nuclear ribonucleoprotein 48kDa protein, inactive tyrosine protein kinase transmembrane receptor ROR1, vacuolar protein sorting-related protein 4B, UPF0469 protein KIAA0907, melanoma-associated antigen D1, HLA class I histocompatibility antigen, alpha chain F, zinc finger protein 506, kinesin-like protein KIF22, phosphatidylinositol phosphate phosphatase Inositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, sarcosine dehydrogenase, mitochondrial, glutamine and serine-rich protein 1, alpha parvin, transmembrane protein 97, importin subunit alpha-7, 60S ribosomal protein L11, TBC1 domain family member 22B, neuronal calcium sensor 1, glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial, E3 ubiquitin-protein ligase RNF187, von Willebrand factor A domain-containing protein 5A, class E basic helix-loop-helix protein 41, box C / D snoRNA protein 1, C-terminal binding protein 1,Acyl-CoA synthetase family member 4, Fos-related antigen 2, mitofusin-1, retinoic acid receptor gamma, uncharacterized protein C17orf85, very long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1, tripartite motif-containing protein 65, thioredoxin reductase 1, cytoplasm, Cdc42 effector protein 3, regulator of chromosome condensation, glutamine-rich protein 1, sphingosine-1-phosphate phosphatase 1, WD repeat-containing protein 92, nonconventional myosin IXa, biogenesis of lysosome-related organelle complex 1 subunit 4, neurobeechiin-like protein 1, phosphomannomutase 1, putative phospholipid transfer ATPase IIA, thioredoxin domain-containing protein 9, inter-alpha trypsin inhibitor heavy chain H5, E3 ubiquitin protein ligase CBL, E3 SUMO protein ligase PIAS1, tenascin, NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondria, glutathione synthetase, ectonucleoside triphosphate diphosphohydrolase 4, type V proton ATPase subunit B, brain isoform, TBC1 domain family member 14, DNA-directed RNA polymerase I and III subunit RPAC2, X-linked retinitis pigmentosa GTPase regulator, PTB domain-containing phagocytic adaptor protein 1, Protein Churchill, SUN domain-containing protein 1, E3 ubiquitin protein ligase pellino homolog 3, synebulin-A, SAP30-binding protein, zinc finger and BTB domain-containing protein 7B, ubinuclein-1, cysteine-tRNA ligase, cytoplasm, protein FAM135A, PERQ amino acid-rich with GYF domain-containing protein 1 1), cytochrome c1, hemoprotein, mitochondria, FUN14 domain-containing protein 1, isocitrate dehydrogenase [NAD] subunit gamma, mitochondria, DNA damage-binding protein 2, integrin beta-5, histone lysine N-methyltransferase 2A,KN motif and ankyrin repeat domain-containing protein 1, small ubiquitin-related modifier 1, delrin-3, replication factor C subunit 3, beta-crystallin B2, elongation complex protein 6, kelch domain-containing protein 2, phocadhesin, 26S proteasome non-ATPase regulatory subunit 7, U4 / U6.U5 tri-snRNP-associated protein 2, calpain 5, cyclin E mutant ex7del, BTB / POZ domain-containing protein 10, beta-soluble NSF attachment protein, SMC5-S MC6 complex localization factor protein 2, WW domain-binding protein 2, F-box / WD repeat-containing protein 8, ceramide synthase 2, WD repeat-containing protein WRAP73, transmembrane protein 165, zinc finger protein AEBP2, charged multivesicular body protein 4a, transcriptional adaptor 3, trafficking kinesin-binding protein 2, [pyruvate dehydrogenase (acetyltransferase)] kinase isozyme 4, mitochondria, cytochrome b-c1 complex subunit Rieske (Cytochrome b-c1 complex subunit Rieske), mitochondria, protein bicaudal D homolog 2, nibrin, SNW domain-containing protein 1, sperm-associated antigen 5, TSC22 domain family protein 1, RBPJ-interacting corepressor 1, kinesin-like protein, general transcription factor II-I repeat domain-containing protein 1, RNA-binding protein PNO1, vacuolar protein sorting-associated protein 52 homolog, actin-associated protein 5, Ran-binding protein 17, intermediate filament family orphan 2, ubiquitin-conjugating enzyme E2 G2, myeloid leukemia factor 1, poly(A) polymerase alpha, protein IMPACT, proto-oncogene tyrosine protein kinase receptor Ret, heat shock factor protein 1, PDZ domain-containing RING finger protein 4, mother against decapentaplegic homolog 4, RING finger protein 113A, neuron navigator 3, conserved oligomeric Golgi complex subunit 3, CASP8-related protein 2, glutathione S-transferase omega-1, BAH and coiled-coil domain-containing protein 1, dynactin subunit 4,Transcription elongation factor B polypeptide 1, tight junction-associated protein 1, anaphase-promoting complex subunit 5, DNA replicative ATP-dependent helicase / nuclease DNA2, integrin alpha-9, sarcospan, catenin delta-1, ankycorbin, lamina-associated polypeptide 2, isoform beta / gamma, intraflagellar transport protein 74 homolog, actin-associated protein 8, neuron-specific calcium-binding protein hippocalcin, pre-mRNA processing factor 40 homolog B, tumor protein D54, mitogen-activated protein kinase Protein kinase kinase kinase 4, myristoylated alanine-rich C kinase substrate, kinetochore protein Spc25, B9 domain-containing protein 1, zinc finger homeobox protein 3, membrane metalloendopeptidase-like 1, vesicle-associated membrane protein-associated protein B / C, zinc finger CCCH domain-containing protein 11A, 60S ribosomal protein L39-like, transcription initiation factor TFIID subunit 7, transforming growth factor beta-1, MAX-like protein X, tRNA pseudouridine synthase A, mitochondria, asparagine synthase kinesin domain-containing protein 1, mRNA capping enzyme, zinc finger protein SNAI2, ETS translocation variant 1, 5'-AMP-activated protein kinase catalytic subunit alpha-2, kinesin-like protein KIFC3, cathepsin L1, aspartyl / asparaginyl beta-hydroxylase, leucine-rich repeat-containing protein 61, zinc finger protein 721, flavin reductase (NADPH), voltage-dependent anion-selective channel protein 1, KH domain-containing, RNA-binding, signal transduction-related protein 3, Putative E3 ubiquitin protein ligase HERC6, ER membrane protein complex subunit 3, homeobox protein Hox-B7, zinc finger C2HC domain-containing protein 1A, T-box transcription factor TBX15, putative zinc finger protein 724, zinc finger protein 486, zinc finger protein 675, prolyl endopeptidase-like, UBX domain-containing protein 8, gamma-aminobutyric acid receptor subunit pi, ATP-dependent RNA helicase DDX54, lysine-specific demethylase 4B, protocadherin-1,Zinc finger protein 490, NKG2D ligand 3, uncharacterized protein C18orf63, peptidyl-prolyl cis-trans isomerase B, plasma alpha-L-fucosidase, notchless protein homolog 1, adenosine 3'-phospho-5'-phosphosulfate transporter 1, nucleus accumbens-associated protein 1, bioorientation of chromosomes in cell division protein 1-like 1), CDK5 and ABL1 enzyme substrate 2, putative tRNA (cytidine(32) / guanosine(34)-2'-O)-methyltransferase, tRNA splicing endonuclease subunit Sen54, beta-galactosidase-1-like protein 2, protein Archease, formin-binding protein 1-like, eukaryotic translation initiation factor 2 subunit 2, centromere / kinetochore protein zw10 homolog, pyridoxal kinase, tyrosine protein phosphatase non-receptor type 14, phosphatidic acid cytidyltransferase 2, M-phase phosphoprotein 8, ribonuclease P / MRP protein subunit POP5, DENN domain-containing protein 5A, nuclear receptor coactivator 6, UDP-N-acetylhexosamine pyrophosphorylase, mediator of RNA polymerase II transcription subunit 22, transcription factor C OE2, Niban-like protein 1, GREB1-like protein, vesicle integral membrane protein VIP36, dynactin subunit 6, sperm-associated antigen 16 protein, Abelson tyrosine protein kinase 2, opioid growth factor receptor, proteasome ubiquitin receptor ADRM1, gamma-aminobutyric acid receptor-related protein, B-cell CLL / lymphoma 9-like protein, retrovirus-like aspartic protease 1, procollagen lysine, 2-oxoglutarate 5-dioxygenase 3, bifunctional arginine demethylase and lysyl hydroxylase JMJD6, histone lysine N-methyltransferase SETD7, Ras-related and pleckstrin homology domain-containing protein 1, death factor 4-like protein 2, kinesin-like protein KIF15, pleckstrin-like domain family B member 1, zinc finger protein ubi-d4,KxDL motif-containing protein 1, transmembrane protein 160, very long chain-specific acyl-CoA dehydrogenase, mitochondria, signal recognition particle receptor subunit beta, small G protein signaling modulator 3, sodium-dependent lysophosphatidylcholine symporter 1, DNA-directed RNA polymerase III subunit RPC5, protein Tob2, UPF0488 protein, Protein C8orf33, DNA-directed RNA polymerase III subunit RPC2, protein spire homolog 1, spectrin beta chain, non-erythroid 2, phosphatidylinositol transfer protein beta isoform, CCAAT / enhancer-binding protein beta, Ras and Rab interactor 2, histone lysine N-methyltransferase 2D, ADP-ribose pyrophosphatase, mitochondrial, peptidyl-prolyl cis-trans isomerase FKBP14, transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha), isoform CRA_c, putative pituitary tumor transforming gene 3 protein Protein, WW domain-containing transcriptional regulatory protein 1, AP-5 complex subunit sigma-1, protein EFR3 homolog A, tubulin polyglutamylase TTLL7, BolA-like protein 3, MORC family CW-type zinc finger protein 3, cleavage stimulatory factor subunit 2 tau variant, pleckstrin homology domain-containing family A member 5, coronin-2B, alpin, reticulon-1, 41 kDa centrosomal protein, NEDD8-conjugating enzyme Ubc12, protein S100-A13, ATP synthase subunit a, fibronectin type III domain-containing protein 3A, serine / threonine protein phosphatase 2A 56 kDa regulatory subunit delta isoform, lipase maturation factor 1, pituitary tumor transforming gene 1 protein-interacting protein, GRAM domain-containing protein 1B, DNA topoisomerase 3-alpha, uncharacterized protein, dynamin-1, cell division cycle protein 23 homolog, pre-mRNA splicing factor SYF1, focal adhesion kinase 1, SH2B adaptor protein 1, breast cancer metastasis suppressor 1-like protein, putative protein N-methyltransferase FAM86B1, dual specificity protein kinase CLK1, non-structural maintenance of chromosomes element 4 homolog A, nephrocystin-1, ectonucleoside triphosphate diphosphohydrolase 6, protein LSM12 homolog,Tubulin-tyrosine ligase-like protein 12, leucine-rich repeat-containing protein 57, nuclear factor type 1C, diphosphoinositol polyphosphate phosphohydrolase 3-alpha, Ras and Rab interactor 1, acyl-CoA dehydrogenase family member 10, coiled-coil domain-containing protein 115, serine / threonine protein kinase B-raf, GTPase, Arf-GAP with ANK repeats and PH domain-containing protein 3, 28S ribosomal protein S15, mitochondrial, E3 ubiquitin protein ligase NEDD4, monofunctional C1-tetrahydrofolate synthase, mitochondrial, 3-hydroxybutyrate dehydrogenase type 2, cysteine-rich with EGF-like domain protein 1 1), zinc finger MYM-type protein 1, exotocin-like 2, LysM and putative peptidoglycan-binding domain-containing protein 2, SLAIN motif-containing protein 2, SWI / SNF complex subunit SMARCC1, charged multivesicular body protein 1a, cytochrome c oxidase assembly protein COX14, uncharacterized protein KIAA1522, kinesin-like protein KIF2C, protein-cysteine ​​N-palmitoyltransferase HHAT, deoxyguanosine kinase, mitochondrial, potassium voltage-dependent channel subfamily G member 1, thyroid transcription factor 1-related protein 26, 89 kDa centrosomal protein, leucine zipper putative tumor suppressor factor 1, Rap guanine nucleotide exchange factor 6, histone lysine N-methyltransferase EHMT2, Fanconi anemia group C protein, COBW domain-containing protein 5, MICAL-like protein 2, zinc finger protein 217, protein CASC3, GPI anchor transamidase, caspase-8, centrin-1, ubiquitin carboxyl-terminal hydrolase 43, protein deglycase DJ-1, zinc finger and BTB domain-containing protein 2, dual specificity mitogen-activated protein kinase kinase 1, Rho-associated GTP-binding protein RhoE, reticulon-3, sialin, kit ligand, nuclear receptor coactivator 3,Calmodulin-regulated spectrin-related protein 2, Wiskott-Aldrich syndrome protein family member 2, histone H1x, Mothers against decapentaplegic homolog 6, Activating transcription factor 7-interacting protein 2 2), uncharacterized protein C17orf112, leukocyte tyrosine kinase receptor, PRELI domain-containing protein 3A, sugar phosphate exchanger 3, type I inositol 3,4-bisphosphate 4-phosphatase, E3 ubiquitin-protein ligase TRIM38, DNA primase small subunit, pleckstrin phase-like domain B member 2, GDH / 6PGL endoplasmic reticulum bifunctional protein, D-beta-hydroxybutyrate dehydrogenase, mitochondria, ubiquitin carboxyl-terminal hydrolase isozyme L5, chloride channel CLIC-like protein 1, zinc finger SWIM domain-containing protein 7, mRNA decapping enzyme 1A, centromeric protein J, G protein pathway suppressor 2, protein CYR61, Rho guanine nucleotide exchange factor 35, integrin alpha-7, transcriptional coactivator YAP1, spermatogenesis-associated serine-rich Protein 2, myotubularin-related protein 14, GATS-like protein 2, oxidative stress-responsive serine-rich protein 1, Tigger transposable element-derived protein 2, mediator of RNA polymerase II transcription subunit 20, guanine nucleotide-binding protein G(I) / G(S) / G(O) subunit gamma-12, mediator of RNA polymerase II transcription subunit 25, protein FAM84B, protein FAN, nitric oxide synthase-interacting protein, striatin, phosducin-like protein, protein phagy homolog, tubby-associated protein 3, SEC14 domain and spectrin repeat-containing protein 1, NHS-like protein 1, lysine-specific demethylase 3A, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, LON peptidase N-terminal domain and RING finger protein 1,DNA topoisomerase 2-binding protein 1, MAP7 domain-containing protein 3, BRCA1-associated RING domain protein 1, DNA-directed RNA polymerase, mitochondria, GAS2-like protein 3, putative 8-oxo-dGTP diphosphatase NUDT15, transmembrane and TPR repeat-containing protein 2, selenoprotein N, zinc finger protein 383, tumor necrosis factor receptor superfamily member 3, transmembrane protein 39A, tetraspanin-10, serine / threonine protein kinase LATS2, BRF1 protein, apoptosis-inducing factor 2, GLTSCR1-like protein, calmodulin-binding transcription activator 1, syndecan 3, uncharacterized protein C1orf198, cell division cycle protein 20 homolog, SH3 domain-containing protein 19, ephrin-A5, synphilin-1, SWI / SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 D member 1), protein FAM204A, dual specificity mitogen-activated protein kinase kinase 3, germinal center-associated nuclear protein, protein transport protein Sec24B, putative UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase LOC100288842, glycogenin-2, EF-hand calcium-binding domain-containing protein 11, ATP-dependent 6-phosphofructokinase, liver type, hydroxyacylglutathione hydrolase-like protein, StAR-related lipid transport protein 13, dynactin subunit 3, alpha-internexin, dehydrogenase / reductase SDR family member on chromosome X, transcription initiation factor IIA subunit 1, copine-2, acyl-CoA:lysophosphosphatidylglycerol acyltransferase 1, dolicholyldiphosphooligosaccharide protein glycosyltransferase subunit 4, Fas-activated serine / threonine kinase,Zinc finger CCCH domain-containing protein 7A, golgin-45, oxidoreductase HTATIP2, neural regeneration-related protein, E3 ubiquitin protein ligase TRIM23, vacuolar protein sorting-associated protein 45, sulfate anion transporter 1, uncharacterized protein C5orf42, small nuclear ribonucleoprotein Sm D3, selenoprotein K, Bcl-2 homologous antagonist / killer, mitochondrial peptide methionine sulfoxide reductase, latent transforming growth factor beta-binding protein 3, uncharacterized protein C11orf80, integrin alpha-11, A-kinase anchor protein 12, Ras-related protein Rab-1B, acetyl-CoA carboxylase 2, RNA-binding motif protein, X-linked 2, tubulin-specific chaperone C, tensin-3, uncharacterized protein CXorf57, ER luminal protein retention receptor 3, disabled homolog 2-interacting protein protein), 7-methylguanosine phosphate-specific 5'-nucleotidase, ataxin-2, caveolin-2, calcium-responsive transactivator, melanophilin, coiled-coil domain-containing protein 130, alpha actinin-3, serine / threonine protein kinase ULK3, myelin expression factor 2, multifunctional methyltransferase subunit TRM112-like protein, protein FAM214A, potassium voltage-gated channel subfamily KQT member 5, sialic acid O-acetylesterase, protein ELFN1, TATA box-binding protein, mitogen-activated protein Protein kinase kinase kinase 12, Aurora kinase A-interacting protein, Tetratricopeptide repeat protein 12, Transcription factor E2F4, CAP-Gly domain-containing linker protein 4, Glutamine synthetase, Signal peptide peptidase-like 2A, Glucoside xylosyltransferase 1, GEM-interacting protein, Zinc finger protein 277, Ubiquitin carboxyl-terminal hydrolase 14, Calcium-binding mitochondrial carrier protein Aralar1, N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, GTP-binding protein Rit1,Matrix Gla protein, cell surface glycoprotein MUC18, polypeptide N-acetylgalactosaminyltransferase 5, calcyphosine, PEST proteolytic signal-containing nuclear protein, serine / threonine protein kinase Nek7, calpain-3, membrane-associated transport protein, V-type proton ATPase subunit B, kidney isoform, sialidase-4, zincfin, Ga protein 552, colipase-like protein 2, ATP-binding cassette subfamily G member 1, fumarate hydratase, mitochondria, protein phosphatase inhibitor 2, tyrosine protein kinase HCK, 2-oxoglutarate dehydrogenase, mitochondria, uncharacterized protein ENSP00000382042, testicular acid phosphatase, lysosomal acid phosphatase, protein FAM195A, nuclear inhibitor of protein phosphatases 1, exosome complex component CSL4, sodium-binding neutral amino acid transporter 5, protein arginine N-methyltransferase 5, peptidase M20 domain-containing protein 2, drebrin, NAD(P)H hydration epimerase, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta 1, DCN1-like protein 2, DnaJ homolog subfamily B member 9, NACHT, LRR and PYD domain-containing protein 7, schizophrenia Statin-B, fatty aldehyde dehydrogenase, D(2) dopamine receptor, reticulon-2, COBW domain-containing protein 6, myosin light chain 1 / 3, skeletal muscle isoform, zinc finger Ran-binding domain-containing protein 2, peptidyl-prolyl cis-trans isomerase FKBP1A, immunoglobulin superfamily member 10, olfactomedin-like protein 2B, proteasome activator complex subunit 1, putative uncharacterized protein C10orf113, protein disulfide isomerase TMX3, plastin-2, transmembrane protein 14D, Nck-related protein 1-like, CXXC-type zinc finger protein 1, guanine nucleotide-binding protein G(s) subunit alpha isoform XLas, integrator complex subunit 10, protein FAM217A, HAUS augmin-like complex subunit 8, mesoderm development candidate 11), zinc finger protein 827, DNA-directed RNA polymerase I subunit RPA49, symplekin, protein spinster homolog 3, 28S ribosomal protein S9, mitochondria, melanocyte-stimulating hormone receptor, enteropeptidase, poly(A) polymerase gamma, ribosomal RNA processing protein 1 homolog A, a disintegrin and metalloproteinase domain-containing protein 15, activator of basal transcription 1 (Activator of basal transcription 1), ribonuclease K6, centromeric protein N, olfactory receptor 5K3, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase, isoform A, serine / threonine protein phosphatase 6 regulatory subunit 1, leukocyte-associated immunoglobulin-like receptor 1, 39S ribosomal protein L44, mitochondria, Ig lambda-2 chain C region, sialoadhesin, transmembrane inner ear expressed protein, tetraspanin-18, protein glutamine gamma glutamyltransferase 4, endothelin-1 receptor, protein FAM127A, period circadian protein homolog 1, autism susceptibility gene 2 protein, voltage-gated T-type calcium channel subunit alpha- 1G, protein hook homolog 2, cyclin Y-like protein 2, BPI-fold-containing family A member 2, solute carrier family 2, facilitated glucose transporter member 2, peroxidasin-like protein, mitochondrial import receptor subunit TOM6 homolog, phosphorylase b kinase gamma catalytic chain, skeletal muscle / cardiac isoform, inosine-5'-monophosphate dehydrogenase 1, proline and serine-rich protein 3, WD repeat-containing protein 54, protein FAM117A, carboxylesterase 3, Bardet-Biedl syndrome 7 protein, exocyst complex component 5, putative phospholipid transport ATPaseVA, pre-B cell leukemia transcription factor-interacting protein 1, MICALC-terminal-like protein, protein transport protein Sec24C, epiplakin, inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4, kinesin heavy chain isoform 5A, hyaluronan and proteoglycan-binding protein 2, intraflagellar transport protein 46 homolog, kinesin-like protein KIF21B, OTU domain-containing protein 6B, CXC motif chemokine 9, uncharacterized protein CXorf23, centrosomal protein of 170 kDa protein B, testis-specific Y-encoded-like protein 2 2), oxysterol receptor LXR beta, Williams-Beuren syndrome chromosome region 16 protein, zinc finger protein 559, glutamic acid-rich protein 3, GLIPR1-like protein 2, pleckstrin homology domain-containing family G member 3, putative vomeronasal receptor-like protein 4, gamma-glutamyltransferase 6, serine / threonine protein kinase pim-3, ribonuclease H2 subunit C, neurexin-3, mucin-16, non-structural maintenance of chromosomes element 1 homolog homolog), E2F-associated phosphoprotein, actin-binding LIM protein 1, non-canonical poly(A) RNA polymerase PAPD7, nuclear receptor-binding factor 2, gypsy retrotransposon integrase-like protein 1, monocarboxylate transporter 4, coiled-coil domain-containing protein 60, inactive phospholipase D5, microtubule cross-linking factor 1, ATP synthase subunit delta, mitochondria, G-patch domain-containing protein 2, protein disulfide-isomerase A2, ATP-binding cassette subfamily A member 9, nonconventional myosin-Ih, band 4.1-like protein 1, gigaxonin, acyl-CoA-binding domain-containing protein 6, complement receptor type 2, eukaryotic elongation factor 2 kinase, large subunit GTPase 1 homolog, tRNA(uracil(54)-C(5))-methyltransferase homolog, nectin-1, zinc finger protein 460, Ras-binding domain-containing protein 2, SLIT-ROBO RhoGTPase-activating protein 3, ETS domain-containing protein Elk-4, nucleoporin-like protein 2, U2 small nuclear ribonucleoprotein cofactor 35 kDa subunit-associated protein 2, bestrophin 3, heparan-alpha-glucosaminide N-acetyltransferase, protein SGT1 homolog, choline phosphate cytidylyltransferase B, fibrillin-3, GPALPP motif-containing protein 1, meiotic arrest female protein 1, ETS domain-containing protein Elk-3, embigin, protein TFG, phosphomannomutase 2, V-type proton ATPase subunit G 1, T-box transcription factor TBX20, beta-1,3-galactosyltransferase 5, olfactory receptor 12D2, laminin subunit alpha-5, forkhead box protein O3, tumor necrosis factor receptor superfamily member 18, leukocyte elastase inhibitor, solute carrier family 22 member 9, nuclease EXOG, mitochondria, leucine-rich repeat LGI family member 4, anosmin-1, 152 kDa centrosome protein, selenocysteine-specific elongation factor, hairy / enhancer-of-split related with YRPW motif protein 1 1), scaffold attachment factor B1, cytochrome b-c1 complex subunit 2, mitochondria, tetratricopeptide repeat protein 8, ubiquitin carboxyl-terminal hydrolase 1, phospholipid phosphatase 5, zinc finger protein 623, zinc finger protein 791, zinc finger protein with KRAB and SCAN domains 1, zinc finger protein 397, O-acetyl-ADP-ribose deacetylase MACROD1, Ig lambda chain V-II region BOH, Ig kappa chain VI region walker, MYCBP-related protein, 60S ribosomal protein L36a, phospholipase ABHD3, TBC1 domain family member 9, RasGTPase-activating protein 1, solute carrier family 35 member E2B, calcium channel flower homolog, T cell-specific surface glycoprotein CD28, sterile alpha motif domain-containing protein 9-like, hydroxysteroid dehydrogenase-like protein 2, tripartite motif-containing protein 26, vitamin D 25-hydroxylase, pre-mRNA splicing factor SLU7, WD repeat-containing protein 75, zinc finger protein 213, zinc finger protein 845, Ras-related protein Rab-6A, zinc finger protein 264, estradiol 17-beta-dehydrogenase 8, dual specificity protein phosphatase 16, protein lin-7 homolog C, major vault protein, interferon-inducible protein 44, Golgi pH regulator A, ethanolamine kinase 1, phosphatidylinositol 3-kinase regulatory subunit alpha, protein phosphatase 1K, mitochondrial, transmembrane protein 222, DC-STAMP domain-containing protein 2, basic salivary proline-rich protein 4 4), Ig kappa chain VI region WAT, fibronectin, FERM domain-containing protein 3, zinc finger protein 507, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8, olfactory receptor 8I2, phosphotyrosine and 3-phosphotyrosine to 3-phosphoinositide dual adaptor, splicing factor 3A subunit 2, dynein heavy chain 6, axoneme, HLA class I histocompatibility antigen, A-30 alpha chain, tryptophan 2,3-dioxygenase, MK L / myocardin-like protein 1, Rho guanine nucleotide exchange factor 5, protein phosphatase 2C-like domain-containing protein 1, histatin 3, 60S ribosomal protein L36a-like, cancer / testis antigen 47A, 97 kDa centrosomal protein, thyroid hormone receptor-related protein 3, beta-galactoside alpha-2,6-sialyltransferase 2, transcription factor ETV6, gamma-glutamyl transpeptidase 1, and suppressor of tumorigenicity 18 protein (Suppression of tumorigenicity 18).protein), calpain 12, neuropeptide FF receptor 1, AP-1 complex subunit gamma-like 2, uncharacterized protein C2orf16, programmed cell death protein 10, TBC1 domain family member 2B, hematopoietic SH2 domain-containing protein, thrombospondin type 1 domain-containing protein 7B, paired-box protein Pax-9, mucin-3A, 5-phosphohydroxy-L-lysine phospholyase, extracellular matrix protein FRAS1, transmembrane protein 201, monoacylglycerol lipase ABHD12, low-density lipoprotein receptor-related protein 1B, DENN domain-containing protein 1A, basic helix-loop-helix domain-containing protein KIAA2018, olfactory receptor 5H15, leucine-rich repeat-containing protein 16A, calcium / calmodulin-dependent protein kinase type 1, G protein-coupled receptor 98, tumor suppressor candidate 2, stress-associated endoplasmic reticulum protein 1, annexin A7, and tetraspanin-8 , 60S ribosomal protein L12, putative ATP-dependent RNA helicase DDX52, ribulose-phosphate 3-epimerase, eukaryotic translation initiation factor 5B, ubiquitin carboxyl-terminal hydrolase 40, trace amine-associated receptor 6, tetrapeptide repeat homeobox protein 1, serine / threonine protein phosphatase 4 regulatory subunit 2, protein capicua homolog (Protein capicua homolog), sphingomyelin phosphodiesterase 3, sodium channel protein type 5 subunit alpha, calcineurin subunit B type 2, methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial, Kelch repeat and BTB domain-containing protein 12, titin, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, pre-mRNA splicing factor SYF2, zinc finger protein 215, collagen alpha-6(VI) chain, zinc finger protein 491, phosphoenolpyruvate carboxykinase, cytosolic [GTP], zinc finger protein 726, PDZ domain-containing protein 8, zinc finger protein 470, glucose-6-phosphate translocase, protein bassoon bassoon), ciliogenesis-associated TTC17-interacting protein, heparan sulfate 6-O-sulfotransferase 2, stabilin-2, desmoglein-2, tumor necrosis factor ligand superfamily member 11, arginase-1, repetin, potassium-transporting ATPase alpha chain 1, C1GALT1-specific chaperone 1, UPF0729 protein C18orf32, cholesterol 24-hydroxylase, spermidine synthase, ATRAF-interacting protein with FHA domain-containing protein A, protein FAM173B, Leydig cell tumor 10 kDa protein homolog, brain-specific angiogenesis inhibitor 1-related protein 2-like protein 1, general transcription factor 3C polypeptide 4, synaptojanin-2, protein KIAA2022, regulatory factor X-related protein, prefoldin subunit 3Poly(ADP-ribose) glycohydrolase, sorting nexin 29, 3-hydroxyisobutyryl-CoA hydrolase, mitochondria, oxysterol-binding protein 1, F-BAR and double SH3 domains protein 2 2), remodeling and spacing factor 1, zymogen granule protein 16 homolog B, ubiquitin carboxyl-terminal hydrolase 3, Rap guanine nucleotide exchange factor 2, dynein heavy chain 1, axoneme, dedicator of cytokinesis protein 3, nucleoporin p58 / p45, MARCKS-related protein, MARVEL domain-containing protein 2, ADP-ribosylation factor-binding protein GGA2, cancer-associated nucleoside triphosphatase, nonconventional myosin-VIIb, cyclin-dependent kinase-like 5, Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, leucine-rich repeat-containing protein 40, solute carrier family 7 member 13, aromatase, thromboxane A synthase, hypoxia up-regulated protein 1 1), translin, ADP-ribosylation factor-like protein 11, peptidyl-prolyl isomerase domain and WD repeat-containing protein 1, proto-oncogene vav, protein mab-21-like 3, Suppressor of tumorigenicity 7 protein-like, apolipoprotein B receptor, dystrophin-associated protein 2, orexin receptor type 1, nucleolar protein 16, 60S ribosomal protein L29, potassium-transporting ATPase alpha chain 2, sodium-driven chloride bicarbonate exchanger, uncharacterized protein C9orf171, ankyrin repeat and LEM domain-containing protein 1, vasohibin 2, putative nuclease HARBI1, hyaluronidase-4, G protein-coupled receptor family C group 6 member A, nucleoporin Nup43, delta(14)-sterol reductase,Phospholipid transport ATPase ID, GTP-binding protein 1, G-patch domain-containing protein 8, IQ motif and SEC7 domain-containing protein 1, selenoprotein S, DnaJ homolog subfamily C member 13, leucine-rich repeat and fibronectin type III domain-containing protein 4, dynein heavy chain 9, axoneme, dynein heavy chain 10, axoneme, echinoderm microtubule-associated protein-like 4, melatonin receptor type 1A, CTP synthase 2, ubiquitin-like modifier activating enzyme ATG7, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, neutrophil cytosolic factor 4, collagen alpha-2(IV) chain, protein unc-13 homolog C, TBC1 domain family member 4, acyl-coenzyme A synthetase enzyme ACSM5, mitochondria, FH1 / FH2 domain-containing protein 1, FYVE, RhoGEF and PH domain-containing protein 5, cilium- and flagella-associated protein 54, alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondria, WD repeat-containing protein 7, transcription factor SOX-30, cationic amino acid transporter 3, mitogen-activated protein kinase kinase kinase 10, glypican-4, transmembrane protein with metallophosphoesterase domain, transcription factor SOX-6, 28S ribosomal protein S14, mitochondria, steroid 21-hydroxylase, XK-related protein 5, N-acetylated-alpha-linked acidic dipeptidase 2 (N-acetylated-alpha-linked acidic dipeptidase 2), mucin-17, butyrophilin-like protein 8, zinc finger protein 28, major facilitator superfamily domain-containing protein 9, small nuclear ribonucleoprotein-related protein N, coiled-coil domain-containing protein 42A, Frizzled-4, putative tripartite motif-containing protein 49B, CC chemokine receptor type 9, 72 kDa centrosomal protein, adenosine receptor A2b, protein CREG1, P2X purinergic receptor 7, F-box-only protein 44, BEN domain-containing protein 7, Rho guanine nucleotide exchange factor 11, lethal (3) malignant brain tumor-like protein 3,Metalloreductase STEAP2, CD97 antigen, putative uncharacterized protein ENSP00000381562, ubiquitin carboxyl-terminal hydrolase isozyme L3, transmembrane protein 114, leucine 20 homeobox, protein Tob1, deoxyribonuclease 1-like 1, neuronal acetylcholine receptor subunit alpha 4, lymphocyte antigen 86, dentin matrix acidic phosphoprotein 1, striatin-interacting protein 1, zinc finger protein 425, inactive phospholipase C-like protein 1, tyrosine protein phosphatase non-receptor type 2, SPARC-related modular calcium-binding protein 1, NACHT, LRR and PYD domain-containing protein 4, olfactory receptor 4K1, BUB3-interacting and GLEBS motif-containing protein ZNF207, protein SSX4, putative uncharacterized protein ENSP00000383407, von Willebrand factor A domain-containing protein 5B2, cytochrome c oxidase subunit 8C, mitochondria, retrotransposon gag domain-containing protein Protein 1, nuclear receptor coactivator 2, laminin subunit alpha-2, Toll-like receptor 3, transmembrane channel-like protein 2, clathrin coat assembly protein AP180, RING finger protein 148, zinc finger protein ZFPM2, brain dopamine neurotrophic factor, testis- and ovary-specific PAZ domain-containing protein 1, vomeronasal organ type 1 receptor 3, receptor expression-enhancing protein 2, secretogranin-1, protocadherin-19, protein RMD5 homolog A, protein dopey-2, protein FAM193A, vesicle transport protein SFT2B, CXC chemokine receptor type 4, sialic acid-binding Ig-like lectin 9, leucine-rich repeat and calponin homology domain-containing protein 2, dynein regulatory complex protein 1, gamma-aminobutyric acid receptor subunit delta, anaphase-promoting complex subunit CDC26, nuclear transcription factor Y subunit alpha, nonconventional myosin XV, olfactory receptor 5D18, sodium- and chloride-dependent glycine transporter 2, peroxiredoxin-4, leucine-rich repeat-containing protein 26,Dystrophia myotonica WD repeat-containing protein, zinc finger protein 853, integrin beta-6, AF4 / FMR2 family member 2, RAS guanyl-releasing protein 2, coiled-coil domain-containing protein 8, cornulin, Metastasis-associated in colon cancer protein 1, mitochondrial import inner membrane translocase subunit Tim17-B, Protocadherin Fat 4, transmembrane protein 205, CX3C chemokine receptor 1, inositol polyphosphate 5-phosphatase K, torsin-3A, PAX-interacting protein 1, G protein-regulated inducer of neurite outgrowth 3 3), class A basic helix-loop-helix protein 15, glutathione peroxidase 7, N-terminal EF-hand calcium-binding protein 2, Ig ​​heavy chain V-II region MCE, CDGSH iron-sulfur domain-containing protein 3, mitochondria, apolipoprotein L6, synapsin-2, chloride transport protein 6, dCTP pyrophosphatase 1, histamine H1 receptor, pyruvate dehydrogenase protein X component, mitochondria, mismatch repair endonuclease PMS2, CD160 antigen, solute carrier family 15 member 3, tRNA dimethylallyltransferase enzymes, mitochondria, voltage-dependent L-type calcium channel subunit alpha-1D, Ras-related protein Rab-30, colorectal mutant oncoprotein, beta-1,4-galactosyltransferase 6, exophilin-5, ribosome biogenesis protein TSR3 homolog, actin filament-associated protein 1-like 2, eukaryotic peptide chain release factor GTP-binding subunit ERF3B, cytochrome c oxidase subunit 5A, mitochondria, protein ENL, CD2 antigen cytoplasmic tail-binding protein 2, neurabin-2, von Willebrand factor A domain-containing protein 9,Ubiquitin carboxyl-terminal hydrolase 47, mitochondrial carrier homolog 2, maximum binding protein MNT, nuclear pore complex protein Nup85, N-alpha acetyltransferase 35, NatC auxiliary subunit, cyclic GMP-AMP synthase, myosin light chain kinase 2, skeletal / cardiac muscle, C-type lectin domain family 4 member F, proteasome assembly chaperone 4, cytochrome c oxidase assembly protein COX15 homolog, R3H domain, In-containing protein 2, protein FAM46A, DnaJ homolog subfamily C member 10, androglobin, ankyrin repeat domain-containing protein 13C, eye absent homolog 1, histone lysine N-methyltransferase EZH2, bistem, dipeptidyl peptidase 3, deleted in malignant brain tumors 1 protein protein), pleckstrin homology domain-containing family B member 1, multidrug resistance-associated protein 4, CapZ-interacting protein, mucin-20, AFG3-like protein 2, obscurin, lipase member J, protein phosphatase 1 regulatory subunit 14B, kinesin-like protein KIFC2, sorting nexin-19, mucin-7, putative uncharacterized protein FLJ37218, protein FAM78A, cytochrome c oxidase subunit 7B, mitochondria, 39S ribosomal protein L17, mitochondria, CLOCK-interacting pacemaker, DNA-binding protein RFX7, protein EVI2B, copper-transporting ATPase 2, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondria, core-binding factor subunit beta, CWF19-like protein 2, E3 ubiquitin-protein ligase RING1, ubiquitin-conjugating enzyme E2 A, deoxyribonuclease 2 alpha, intraflagellar transport protein 80 homolog, protein Yippy-like 3, calcium-dependent secretion activating factor 1, protein YIPF1, 7-dehydrocholesterol reductase, gamma-tubulin complex component 6, intraflagellar transport protein 140 homolog, nuclear pore glycoprotein 210-like, ribonuclease 3, protein S100-A7, protein AF-17, Fanconi anemia group E protein, NEDD8-activating enzyme E1 catalytic subunit, WD repeat-containing protein 97, hematological and neurological expressed 1 protein, uncharacterized protein C20orf195, putative glycosylation-dependent cell adhesion molecule 1, nucleolar and coiled body phosphoprotein 1, intraflagellar transport protein 88 homolog, syndecan-1, XK-related protein 9.Uncharacterized protein C9orf78, cTAGE family member 5, glutaryl-CoA dehydrogenase, mitochondria, BMP / retinoic acid-inducible neural-specific protein 2, homeodomain-interacting protein kinase 3, bone marrow stromal antigen 2, myocyte-specific enhancer factor 2C, stromal cell-derived factor 2, lymphoid limiting membrane protein, myosin-binding protein H-like, WD repeat-containing protein 5, a disintegrin and metalloproteinase domain-containing protein 17, cerebral cavernous hemangioma 2 protein, DNA dC->dU editing enzyme APOBEC-3C, protein FAM185A, far-upstream element-binding protein 2, vacuolar protein sorting associating protein VTA1 homolog, TBC1 domain family member 30, intercellular adhesion molecule 1, vesicle, overexpressed in cancer, prosurvival protein 1, translocating chain-associated membrane protein 2 2), target of Nesh-SH3, serine / threonine protein kinase VRK1, uncharacterized protein DKFZp434B061, putative coiled-coil-helix domain-containing protein CHCHD2P9, mitochondria, ataxin-7, eukaryotic translation initiation factor 3 subunit G, serine / threonine protein phosphatase 2A 65 kDa regulatory subunit A beta isoform, exocyst complex component 3, cathepsin B, G1 / S-specific cyclin E1, ubiquitin carboxyl-terminal hydrolase 30, ubiquitin carboxyl-terminal hydrolase 51, interleukin-1 receptor accessory protein-like 1, ankyrin-1, transmembrane protein 106C, phosphatidylinositol transfer protein alpha isoform, transportin-2, polyhomeotic-like protein 3, charged multivesicular body protein 2b, ubiquitin D, RING finger protein unkempt (RING finger protein unkempt) homolog), protein SMG7, E3 ubiquitin protein ligase RNF144A,Mediator of RNA polymerase II transcription subunit 15, cytochrome c oxidase subunit 8A, mitochondria, NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria, calcipressin-1, vesicle fusion ATPase, putative ATP-dependent RNA helicase DHX33, alpha-synuclein, carbonic anhydrase 2, complement factor H, RalBP1-related Eps domain-containing protein 2, semaphorin 3A, core histone macroH2A.2, melanotransferrin, SKI family transcriptional corepressor 2, collagen Alpha 1(VI) chain, Dachshund homolog 1, protein BTG1, cyclin-dependent kinase 18, T-box transcription factor TBX2, IgGFc-binding protein, voltage-dependent L-type calcium channel subunit alpha-1C, zinc finger protein 516, guanine nucleotide-binding protein G(olf) subunit alpha, melanoma-associated antigen 9, protocadherin gamma-B2, RING finger protein 112, transcription factor SOX-10, peroxisome assembly protein 12, collagen alpha-1(XI) chain, tripartite motif-containing protein 67, H(+) / Cl(-) exchanger 5, putative phospholipid-transporting ATPase VB, aldose reductase, receptor tyrosine-protein phosphatase zeta, kinesin-like protein KIF2A, arginyl-tRNA protein transferase 1, ATP synthase subunit epsilon, mitochondrial, alpha protein kinase 2, putative hexokinase HKDC1, metastasis-associated protein MTA1, seizure 6-like protein 2, chloride channel protein 2, RNA 3'-terminal phosphate cyclase , poly(rC)-binding protein 4, oxidation resistance protein 1, kinesin light chain 4, E3 ubiquitin-protein ligase TRIM33, receptor tyrosine protein phosphatase gamma, chromobox protein homolog 8, cathepsin F, integrin beta-8, C-type lectin domain family 11 member A, keratin, type I cytoskeleton 27, ankyrin repeat and SAM domain-containing protein 1A, eukaryotic translation initiation factor 2-alpha kinase 4, transforming growth factor-beta-induced protein ig-h3, jerky protein homolog,Fucose-1-phosphate guanylyltransferase, ATP-binding cassette subfamily A member 13, sodium-dependent phosphate transporter 2, outer dense fiber protein 2-like, G1 / S-specific cyclin D1, phosphatidylinositol 3-kinase catalytic subunit type 3, immunity-related GTPase family Q protein, transmembrane O-methyltransferase, sulfate transporter, protein eva-1 homolog A, putative tyrosine-protein phosphatase auxilin, ankyrin repeat and SOCS box protein 11, protein cordon blue, bestrophin-1, putative ribosome-binding factor A, mitochondria, protocadherin cancer Ma-A2, formin-1, nuclear receptor subfamily 1 group D member 2, interleukin-17 receptor D, rootletin, serine incorporator 5, glutamate receptor ionotropic, kainate 3, plexin-A2, tRNA(uracil-5-)-methyltransferase homolog A, WD repeat-containing protein 60, hemicentin-1, E3 ubiquitin-protein ligase MIB2, lysosome-associated membrane glycoprotein 1, dynein heavy chain domain-containing protein 1, uncharacterized Protein C17orf51, UPF0669 protein C6orf120, La-related protein 7, DNA-binding protein RFX5, alpha-1-syntrophin, Nance-Horan syndrome protein, Dickkopf-related protein 3, voltage-dependent T-type calcium channel subunit alpha-1H, HLA class I histocompatibility complex, A-69 alpha chain, F-box / LRR repeat protein 18, arrestin domain-containing protein 1, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, receptor tyrosine-protein phosphatase mu, thioredoxin domain-containing protein 12, adhesion G protein-coupled receptor A3, proline synthase cotranscriptional bacterial homolog protein, solute carrier family 52, riboflavin transporter, member 2, cystic fibrosis transmembrane conductance regulator, kinesin-like protein KIF3C, endothelin B receptor, sideroflexin-3, tubulin alpha-3E chain, SH3 domain-containing RING finger protein 3,GTP-binding protein Di-Ras2, low-density lipoprotein receptor-related protein 2, pyrin, trinucleotide repeat-containing gene 6C protein, Fanconi anemia group B protein, coagulation factor VIII, E3 ubiquitin protein ligase TRIM13, lysophosphatidic acid receptor 1 collagen alpha-1(XXII) chain, low-affinity sodium-glucose cotransporter, density regulatory protein, uncharacterized protein C15orf52, zinc finger SWIM domain-containing protein 6, protocadherin gamma A12, importin subunit alpha-3, cubilin, putative segment polarity protein dishevelled homolog DVL1P1, aggrecan core protein, prohibitin-2, Rho GTPase-activating protein 33, myotubularin-related protein 3, phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform, biotin protein ligase, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4, protein AHNAK2, inosine triphosphate pyrophosphatase, cadherin-2, DNA helicase MCM9, putative signal peptidase complex catalytic subunit SEC11B, maestro fever-like repeat-containing protein family member 6, prolyl 4-hydroxylase subunit alpha-2, integral membrane protein DGCR2 / IDD, zinc finger protein 469, sorbin and SH 3 domain-containing protein 1, multidrug resistance-associated protein 5, Down syndrome critical region protein 3, V-set and immunoglobulin domain-containing protein 10-like, coronin-6, kinesin-like protein KIF13B, Tribbles homolog 2, STAM-binding protein, zinc finger E-box-binding homeobox 2, FERM domain-containing protein 5, tropomodulin-2, lymphoid enhancer-binding factor 1, general receptor for phosphoinositides 1-related scaffolding protein, dedicator of cytokinesis protein 10, protein ITFG3, heat shock protein beta-8, secreted phospholipase A2 receptor, FYVE, RhoGEF and PH domain-containing protein 6,Ankyrin repeat domain-containing protein SOWAHB, Nurim, integral membrane protein GPR137C, keratin, type II cytoskeleton 1b, netrin receptor UNC5A, receptor tyrosine protein phosphatase C, UPF0606 protein KIAA1549, RNA-binding protein Nova-1, zinc finger protein 317, lysophosphatidylcholine acyltransferase, ATP-binding cassette subfamily C member 11, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, sodium-dependent phosphate transport protein 2C, dynein light chain 4, axoneme, cyclin-dependent kinase 3, vitamin K-dependent gamma-carboxylase, BTB / POZ domain-containing protein KCTD15, cyclin-associated protein FAM58A, Lipid motif-containing protein 2, calcium / calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, guanine nucleotide-binding protein subunit beta-4, ubiquitin-like conjugating enzyme ATG10, protein SMG8, putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinating enzyme ALG13, protein naked cuticle homolog 1, protein S100-A1, tumor-associated antigen Ma2, transmembrane protein 106B, hephaestin, POU domain, class 2, transcription factor 1, maltase-glucoamylase, intestine, Kelch domain-containing protein 8B, VWFA and cache domain-containing protein 1, adenylate kinase isoenzyme 5, BTB / POZ domain-containing protein KCTD9, ankyrin-3, TBC1 domain family member 8B, intraflagellar transport protein 56, G-protein-coupled receptor 56, protocadherin fat 3, cortactin-binding protein 2, 5,6-dihydroxyindole-2-carboxylic acid oxidase, multidrug and toxin efflux protein 1, peroxisome biogenesis Factor 1, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondria, ropporin-1A, histone deacetylase 11, collagen alpha-1(VIII) chain, zinc finger HIT domain-containing protein 1, citronellol Rho-interacting kinase, uncharacterized protein C20orf194, sodium / potassium / calcium exchanger 1, paired box protein Pax-1, homeobox protein TGIF1, transmembrane 9 superfamily member 4, CUB and sushi domain-containing protein 1 (CUB and sushidomain-containing protein 1), FRAS1-related extracellular matrix protein 1, leucine-rich repeat protein 1, protein FAM127B, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, glioma tumor suppressor candidate region gene 1 protein, tectonic-1, zinc finger protein 618, palmitoyl protein thioesterase 1, serine / threonine protein kinase 36, tetratricopeptide repeat protein 31, neurobitisin, adenosylhomocysteinase 3, sickle tail protein homolog, fibrocystin, mastermind-like protein 2, frizzled-8, vesicle transport protein SFT2C, Pecanex-like protein 2, and suppressor of tumorigenicity 5 Protein, zinc finger and BTB domain containing protein 10, matrix metalloproteinase 24, peroxisome biogenesis factor 19, protein piccolo, prostaglandin reductase 1, electrogenic sodium bicarbonate symporter 4, neuronal PAS domain-containing protein 3, homeobox even-skipped homolog ...

Claims

1. An artificial nucleic acid molecule comprising at least one coding region, said at least one coding region comprising: at least one antigenic peptide or protein; and at least one additional amino acid sequence derived from at least one immune response activation signaling protein located in the outer plasma membrane; the at least one immune response activation signaling protein located in the outer plasma membrane is human CTLA4; An artificial nucleic acid molecule, characterized in that the at least one additional amino acid sequence comprises or consists of at least one transmembrane domain from human CTLA4.

2. An artificial nucleic acid molecule as described in claim 1, wherein the at least one additional amino acid sequence further comprises at least one cytoplasmic domain.

3. An artificial nucleic acid molecule as described in claim 1 or 2, wherein the at least one antigenic peptide or protein is selected from or derived from a tumor antigen, a virus, a bacterium, a protozoan, a fungus, or an alloantigen.

4. An artificial nucleic acid molecule described in any of claims 1 to 3, wherein the at least one antigenic peptide or protein comprises or consists of an amino acid sequence corresponding to any of SEQ ID NOs: 3719 to 27945, 76420 to 76439, and 76440 to 76474, and / or is encoded by a nucleic acid sequence corresponding to any of SEQ ID NOs: 27946 to 52172, 76495 to 76514, 52173 to 76399, 76570 to 76589, 76515 to 76549, and 76590 to 76624.

5. The tumor antigen is BRAF, PIK3CA, KRAS, IDH1, TP53, NRAS, AKTI, SF3B1, CDKN2A, RPSAP58, EGFR, NY-ESO1, MUC-1, 5T4, Her2, MAGE-A3, LY6K, CEACAM6, CEA, MCAK, KK-LC1, gastrin, VEGFR2, MMP-7, MPHOSPH1, MAGE-A4, MAGE-A1, MAGE-C1, PRAME, survivin, The artificial nucleic acid molecule according to claim 3 or 4, which is selected from MAGE-A9, MAGE-C2, FGFR2, WT1, PSA, PSMA, prostate-specific antigen precursor, Kitakyushu lung cancer antigen 1, trophoblast glycoprotein, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 2A isoform 1 / 2 / 3, multiple tumor suppressor 1 / cyclin-dependent kinase 4 inhibitor p16, GTPase NRas, or any combination thereof.

6. An artificial nucleic acid molecule described in any of claims 1 to 5, wherein the at least one further amino acid sequence comprises or consists of at least one transmembrane domain and at least one cytoplasmic domain, comprising or consisting of an amino acid sequence corresponding to SEQ ID NO: 76636, and is encoded by a nucleic acid sequence corresponding to any of SEQ ID NOs: 76659, 76682, 76705, 76728, 76751, 76774, 76797, 76820, 76843, 76866, 76889, 76912, 76935, 76947, 77066, and 77004 to 77017.

7. An artificial nucleic acid molecule described in any of claims 1 to 6, wherein the transmembrane domain comprises or consists of an amino acid sequence corresponding to SEQ ID NO: 200 and is encoded by a nucleic acid sequence corresponding to any of SEQ ID NOs: 408, 616, 824, 1032, 1240, 1448, 1656, 1864, 2072, 2280, 2488, 2696, and 2904.

8. An artificial nucleic acid molecule described in any one of claims 1 to 7, further encoding at least one signal peptide and / or at least one linker in the at least one coding region.

9. An artificial nucleic acid molecule described in any one of claims 1 to 8, wherein at least one coding region further encodes at least one T helper epitope.

10. An artificial nucleic acid molecule described in any one of claims 1 to 9, which comprises at least one coding region of the following formula (I) in the 5'→3' direction: 【Chemistry 1】 (In the formula, "SIG" encodes the signal peptide, "L" encodes a linker sequence, Each "AN" encodes the same or a different antigenic peptide or protein, "IM" encodes a helper epitope, "TMD / TMCD" encodes an amino acid sequence derived from the transmembrane domain of CTLA4 as defined in claim 7, or an amino acid sequence derived from the transmembrane domain and the cytoplasmic domain as defined in claim 6; m and o are each independently an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; b, d, and n are each independently an integer selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; c is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; e is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; a is 1, p is 1.

11. An artificial nucleic acid molecule described in any one of claims 1 to 10, wherein the artificial nucleic acid molecule is RNA selected from mRNA, viral RNA, replicon RNA, or circular RNA.

12. An artificial nucleic acid molecule described in any one of claims 1 to 11, wherein the artificial nucleic acid molecule is modified and / or stabilized.

13. - the G / C content of the at least one coding region is increased compared to the G / C content of the corresponding coding sequence of the corresponding wild-type artificial nucleic acid, and / or - the C content of said at least one coding region is increased compared to the C content of the corresponding coding sequence of the corresponding wild-type artificial nucleic acid, and / or - the codons of said at least one coding region are adapted to human codon usage, so that the Codon Adaptability Index (CAI) is increased or maximized in said at least one coding sequence of said artificial nucleic acid; An artificial nucleic acid molecule according to any one of claims 1 to 12, wherein the amino acid sequence encoded by the artificial nucleic acid is unchanged compared to the amino acid sequence encoded by the corresponding wild-type artificial nucleic acid.

14. The at least one coding region is selected from the group consisting of SEQ ID NOs: 585, 1001, 1417, 1833, 2249, 793, 1209, 1625, 2041, 2457, 2665, 2873, 616, 824, 1032, 1240, 1448, 1656, 1864, 2072, 2280, 2488, 2696, 2904, 76682, 76705, 76728, 76751, and 7677. 4, 76797, 76820, 76843, 76866, 76889, 76912, 76935, 76947, 77004 to 77017, 77066, 564, 772, 980, 1188, 1396, 1604, 1812, 2020, 2228, 2436, 2644, and 2852. The artificial nucleic acid molecule according to claim 13, comprising or consisting of a nucleic acid sequence corresponding to any one of the following:

15. The artificial nucleic acid molecule according to any one of claims 1 to 14, comprising the following elements in the 5'→3' direction: a) a 5'-cap structure, b) a 5'-UTR element; c) at least one coding sequence as defined in any one of claims 1 to 14, d) a 3'-UTR element, and e) Poly(A) tail.

16. An artificial nucleic acid molecule described in any one of claims 1 to 15, comprising at least one histone stem loop.

17. A vaccine characterized by comprising at least one artificial nucleic acid molecule described in any one of claims 1 to 16.

18. The vaccine of claim 17, comprising a pharmaceutically acceptable carrier and / or excipient.

19. A vaccine described in claim 17 or 18, comprising at least two multiple artificial nucleic acid molecules described in any of claims 1 to 16.

20. The vaccine described in claim 19, wherein at least two of the multiple artificial nucleic acid molecules encode different antigenic peptides or proteins.

21. The vaccine described in claim 20, wherein the antigenic peptide or protein is selected from the antigenic peptides or proteins defined in any of claims 3 to 5.

22. The artificial nucleic acid molecule a) complexed with one or more cationic or polycationic compounds, and / or 22. The vaccine of any one of claims 17 to 21, wherein the vaccine is b) complexed with one or more lipids to form lipid nanoparticles, lipoplexes, and / or liposomes.

23. The vaccine of claim 22, wherein the one or more cationic or polycationic compounds are cationic or polycationic polymers, cationic or polycationic peptides or proteins, cationic or polycationic polysaccharides, and / or cationic or polycationic lipids.

24. The vaccine of claim 23, wherein the cationic or polycationic peptide or protein is protamine.

25. A kit comprising an artificial nucleic acid molecule described in any one of claims 1 to 16, or a vaccine described in any one of claims 17 to 24.

26. An artificial nucleic acid molecule described in any one of claims 1 to 16, a vaccine described in any one of claims 17 to 24, or a kit described in claim 25, for use as a pharmaceutical.

27. ​​An artificial nucleic acid molecule described in any of claims 1 to 16, a vaccine described in any of claims 17 to 24, or a kit described in claim 25, for use in a method for the treatment or prevention of cancer; an infectious disease including viral, bacterial, fungal, or protozoan infection; an autoimmune disease; graft-versus-host disease (GvHD); or an allergy.

Images