Pyrimidin-4(3H)-one derivatives as TRPV4 antagonists

Abstract

The present invention relates to pyrimidin-4(3H)-one derivatives that act as TRPV4 receptor modulators. The present invention also relates to methods for preparing pyrimidin-4(3H)-one derivatives and to the use of said derivatives for the treatment of a wide range of diseases, syndromes, and disorders, particularly inflammation, pain, and urinary diseases or disorders.

Description

Technical field

[0001] The present invention relates to pyrimidin-4(3H)-one derivatives that act as TRPV4 receptor modulators. The invention also relates to processes for the preparation of pyrimidin-4(3H)-one derivatives and the use of said derivatives for the treatment of a wide range of diseases, syndromes and disorders, especially inflammation, pain and urological diseases or disorders. [Background technology]

[0002] Transient receptor potential 4 (TRPV4) belongs to the vanilloid subfamily of TRP channels. 2+ It is a permeable, non-selective cation channel. Although TRPV4 was originally identified as a channel activated by hypotonicity-induced cell swelling, it has been mediated by heat (>24–27°C), mechanical stimuli, endogenous substances such as arachidonic acid, and its cytochrome P450. It is also activated by a variety of physical and chemical stimuli, including metabolites derived from it (epoxyeicosatrienoic acid), endocannabinoids (anandamide and 2-arachidonoylglycerol), and synthetic phorbol derivatives (e.g. 4α-PDD). . (Non-Patent Document 1: Liedtke, W., et al., Cell, 2000, 103, 525-535; Non-Patent Document 2: Watanabe, H., et al., Nature, 2003, 424, 434-438; Non-Patent Document 3: Watanabe, H., et al., J Biol Chem, 2002, 277, 47044-47051; and Non-Patent Document 4: Watanabe, H., et al., J Biol Chem, 2002, 277, 13569-13577). TRPV4 is a versatile channel that is regulated by multiple stimuli and acts as an integrator that sums up the effects of all activator contributions.

[0003] TRPV4 channels are expressed in pain pathways such as dorsal root ganglion and trigeminal ganglion neurons. The use of TRPV4 knockout mice and TRPV4 knockdown studies indicate that TRPV4 is involved in both inflammatory and neuropathic pain states. TRPV4 knockout mice show reduced post-inflammatory thermal hyperalgesia induced by carrageenan or complete Freund's adjuvant (Tadaka, H., et al., J Biol Chem, 2004, 279, 35133-35138). Intrathecal injection of TRPV4 antisense oligonucleotides (ODN) reduces mechanical hyperalgesia induced by carrageenan or inflammatory mediators (Lee, H., et al., J Neurosci, 2005, 25, 1304-1310). Similarly, TRPV4 knockout mice show reduced mechanical hyperalgesia associated with chemotherapy or diabetes-induced neuropathy (Alessandri-Haber, N., et al., J Neurosci, 2006, 26, 3864). -3874). Intrathecal administration of TRPV4 antisense ODN markedly attenuates mechanical hyperalgesia and nociceptive behavior to hypotonic stimulation in chemotherapy, alcoholism, diabetes, and HIV treatment-induced neuropathy models. increase response (8: Alessandri-Haber, N., et al., J Neurosci, 2004, 24, 4444-4452; and 9: Alessandri-Haber, N., et al., J Neurosci, 2008, 28, 1046-1057). TRPV4 is abundant in colonic sensory nerves. Behavioral responses to noxious bloating of the colon are greatly reduced in TRPV4-knockout mice. Hyperalgesia and allodynia to colorectal distension induced by inflammatory mediators (e.g., PAR2 agonists, serotonin, and histamine) are also significantly suppressed by TRPV4 knockdown (Cenac, N., et al., Gastroenterology, 2008, 135, 937-946).

[0004] TRPV4 is highly expressed in urothelial cells and plays a role in sensing bladder filling. The development of cystitis-induced bladder dysfunction is severely impaired in TRPV4 knockout mice. TRPV4 antagonists increased functional bladder capacity and decreased voiding frequency in mice and rats with cystitis (Everaerts, W., et al., Proc Natl Acad Sci USA, 2010, 107, 19084-19089).

[0005] TRPV4 is widely distributed in various peripheral tissues including lung, spleen, testis, fat, brain, cochlea, skin, smooth muscle, kidney, liver, vascular endothelium, central nervous system, peripheral nervous system, and bone. Using the TRPV4 knockout / knockdown strategy, TRPV4 is involved in numerous physiological processes, including osmotic homeostasis, thermal and mechanosensation, vasoregulation, regulation of neural excitability, bladder micturition, and bone formation ( Non-Patent Document 12: Mizuno, N., et al., Am J Physiol Cell Physiol, 2003, 285, C96-101.; Non-Patent Document 5: Tadaka, H., et al., J Biol Chem, 2004, 279, 35133-35138. Non-Patent Document 7: Alessandri-Haber, N., et al., J Neurosci, 2006, 26, 3864-3874; Non-Patent Document 13: Koehler, R., et al. Arterioscler Thromb Vasc Biol, 2006, 26, 1495-1502 Non-Patent Document 14: Gevaert, T., et al., J Clin Invest, 2007, 117, 3453-3462; Non-Patent Document 15: Thorneloe, K.S., et al., J Pharmacol Exp Ther, 2008, 326, 432-442; Non-Patent Document 16: Masuyama, R., et al., Cell Metab, 2008, 8, 257-265).

[0006] Compounds having TRPV4 inhibitory activity are disclosed in Patent Documents 1-10. However, the compounds of the invention are not disclosed in any document. [Prior art documents] [Patent document]

[0007] [Patent document 1] WO2019244937 [Patent Document 2] WO2018055527 [Patent Document 3] WO2018055526 [Patent Document 4] WO2018055524 [Patent Document 5] WO2013012500 [Patent Document 6] WO2012174342 [Patent Document 7] WO2012174340 [Patent Document 8] WO2011119701 [Patent Document 9] WO2013146754 [Patent Document 10] WO2015046193 [Non-Patent Literature]

[0008] [Non-Patent Document 1] Liedtke, W., et al., Cell, 2000, 103, 525-535 [Non-Patent Document 2] Watanabe, H., et al., Nature, 2003, 424, 434-438 [Non-Patent Document 3] Watanabe, H., et al., J Biol Chem, 2002, 277, 47044-47051 [Non-Patent Document 4] Watanabe, H., et al., J Biol Chem, 2002, 277, 13569-13577 [Non-Patent Document 5] Tadaka, H., et al., J Biol Chem, 2004, 279, 35133-35138 [Non-Patent Document 6] Lee, H., et al., J Neurosci, 2005, 25, 1304-1310 [Non-Patent Document 7] Alessandri-Haber, N., et al., J Neurosci, 2006, 26, 3864-3874 [Non-Patent Document 8] Alessandri-Haber, N., et al., J Neurosci, 2004, 24, 4444-4452 [Non-Patent Document 9] Alessandri-Haber, N., et al., J Neurosci, 2008, 28, 1046-1057 [Non-Patent Document 10] Cenac, N., et al., Gastroenterology, 2008, 135, 937-946 [Non-Patent Document 11] Everaerts, W., et al., Proc Natl Acad Sci USA, 2010, 107, 19084-19089 [Non-Patent Document 12] Mizuno, N., et al., Am J Physiol Cell Physiol, 2003, 285, C96-101 [Non-Patent Document 13] Koehler, R., et al., Arterioscler Thromb Vasc Biol, 2006, 26, 1495-1502 [Non-Patent Document 14] Gevaert, T., et al., J Clin Invest, 2007, 117, 3453-3462 [Non-Patent Document 15] Thorneloe, K.S., et al., J Pharmacol Exp Ther, 2008, 326, 432-442 [Non-Patent Document 16] Masuyama, R., et al., Cell Metab, 2008, 8, 257-265 [Non-Patent Document 17] Cortright, D.N., et al., Curr Pharm Des, 2009, 15, 1736-1749 [Non-Patent Document 18] Jia, Y. et al., Biochim Biophys Acta, 2007, 1772, 915-927 [Non-Patent Document 19] Inoue, R., et al., Pharmacol Ther, 2009, 123, 371-385 [Non-Patent Document 20] Hsu, Y.J., et al., Biochim Biophys Acta, 2007, 1772, 928-936 [Non-Patent Document 21] Casas, S., et al., Diabetologia, 2008, 51, 2252-2562 [Non-Patent Document 22] Brierley, S.M., et al., Gastroenterology, 2008, 134, 2059-2069 [Outline of the invention] [Problems to be solved by the invention]

[0009] Mammalian diseases, syndromes, conditions, or disorders in which the diseases, syndromes, conditions, or disorders are affected by modulation of TRPV4 channels, e.g., chronic pain, neuropathic pain including diabetic neuropathy, postoperative pain, degenerative Arthrosis, rheumatoid arthritis pain, cancer pain, neuralgia, neuropathy, hyperalgesia, nerve damage, cardiovascular disease, kidney disease, diabetes, irritable bowel syndrome, inflammatory bowel disease, asthma, chronic obstructive pulmonary disease In the art are TRPV4 antagonists that can be used to treat inflammatory diseases, including (COPD) and chronic obstructive airway disease (COAD); urological diseases or disorders, including detrusor overactivity or overactive bladder, urinary incontinence; (Non-Patent Document 17: Cortright, D.N., et al., Curr Pharm Des, 2009, 15, 1736-1749; Non-Patent Document 18: Jia, Y. et al., Biochim Biophys Acta, 2007, 1772, 915 -927; Non-Patent Document 19: Inoue, R., et al., Pharmacol Ther, 2009, 123, 371-385; Patent Document 21: Casas, S., et al., Diabetologia, 2008, 51, 2252-2562; Non-Patent Document 22: Brierley, S.M., et al., Gastroenterology, 2008, 134, 2059-2069; K.S., et al., J Pharmacol Exp Ther, 2008, 326, 432-442; and Non-Patent Document 16: Masuyama, R., et al., Cell Metab, 2008, 8, 257-265). [Means for solving the problem]

[0010] Relative to other compounds disclosed in the art, the compounds of the present invention exhibit lower toxicity, favorable absorption and distribution, favorable solubility, favorable plasma protein binding, fewer drug-drug interactions, favorable metabolic stability, It can exhibit low inhibitory activity and / or low QT prolongation activity on human delayed rectifier potassium ion channel gene (hERG) channel.

[0011] The present invention provides: [1] A compound of formula (I) below: [formation] During the ceremony, R. 1 and R 2 are hydrogen, hydroxyl, halogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, (C 3 -C 7 ) cycloalkyl, and phenyl (C 0 -C 4 ) alkyl (where the (C 3 -C 7 )cycloalkyl or phenyl(C 0 -C 4 ) alkyl is halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, and (C 1 -C 6 ) optionally substituted with 1 to 4 substituents independently selected from the group consisting of haloalkoxy); or R 1 and R 2 is a 3- to 8-membered ring which, together with the atoms to which they are attached, may contain 0 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen (wherein said 3- to 8-membered ring are halogens, hydroxyls, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); preferably R 1 and R 2 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, and (C 3 -C 7 ) independently selected from the group consisting of cycloalkyl; or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic ring; R. 3 are hydrogen, fluorine, methyl, ethyl, and (C 1 -C 6 ) independently selected from the group consisting of haloalkyl; preferably R 3 is independently selected from the group consisting of hydrogen, fluorine, and methyl; X is a chemical bond, -N(R 4 )-, -(C(R 5 )(R 6 )) n -, -(C 3 -C 8 )cycloalkyl-, -C(R 5 )=C(R 6 )-, -C(=O)-, -CR 4 (N(R 5 )(R 6 ))-, -[(C(R 5 )(R 6 )) n O]-, -[(C(R 5 )(R 6 )) n N(R 4 )]-, -[(C(R 5 )(R 6 )) n S]-, and -[N(R 4 )(C(R 5 )(R 6 )) n ]-; preferably X is a chemical bond, -(C(R 5 )(R 6 )-(CH 2 ) m )-、-(C 3 -C 8 )cycloalkyl-, -CH=CH-, and -CH 2 is selected from the group consisting of O-; m is 0, 1, 2, or 3; more preferably X is a chemical bond, -C(R 5 )(R 6 )CH 2 -, -C(R 5 )(R 6 )-, -cyclopropyl-, -CH=CH-, and -CH 2 is selected from the group consisting of O-; even more preferably X is a chemical bond, -CH 2-, -CF 2 -, -CH 2 CH 2 selected from the group consisting of -, -CH(OH)-, and -CH(Me)-; R. 4 is hydrogen or (C 1 -C 6 ) is an alkyl; R. 5 and R 6 are hydrogen, halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, hydroxyl (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and (C 1 -C 6 ) independently selected from the group consisting of haloalkoxy; 5 and R 6 are hydrogen, halogen, hydroxyl, and (C 1 -C 6 ) independently selected from the group consisting of: alkyl; more preferably R 5 and R 6 is independently selected from the group consisting of hydrogen, fluorine, hydroxyl, and methyl; where R 5 If there are two or more, R 5 are the same or different; where R 6 If there are two or more, R 6 are the same or different; n is 1, 2, 3, or 4; preferably n is 1 or 2; q is 1, 2, 3, or 4; preferably q is 1 or 2; r is 1, 2, 3, or 4; preferably r is 1 or 2; s is 1, 2, 3, or 4; preferably s is 1 or 2; Ar 1 are aryl and heteroaryl (these are hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R 7 , -C(=O)NR 7 R. 8 , -NHSO 2 R. 7 , -SO 2 NR 7 R. 8 , (C 1 -C 6 ) alkylthio-, (C 1 -C 6 ) haloalkylthio-, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 7 R. 8 , tri(C 1 -C 6 ) alkylsilyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkenyl, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, heterocyclyl (C 0 -C 6 ) alkoxy, heteroaryl (C 0 -C 6 ) alkoxy, and optionally substituted with 1 to 6 substituents independently selected from the group consisting of substituents Q); 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkenyl, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, heterocyclyl (C 0 -C 6 )alkoxy, or heteroaryl(C 0 -C 6 )alkoxy is halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, phenyl, -NR a R. b , R a R. b N(C 1 -C 6 ) alkyl, R a R. b N(C 1 -C 6 )alkoxy, -C(=O)NR a R. b , -C(=O)R a , -SO 2 (C 1 -C 6 ) alkyl, -SO 2 NR a R. b , and R a R. b NC(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy; 3 -C 7 ) cycloalkyl may be optionally substituted with hydroxyl or cyano; wherein substituent Q is [formation] [formation] where the substituent Q is halogen, hydroxyl, or (C 1 -C 6 ) optionally substituted with alkyl; Preferably, aryl is phenyl or naphthyl, preferably heteroaryl is an unsaturated or partially saturated heteroatom having 1 to 4 heteroatoms independently selected from O, N and S, or carbonyl monocyclic or bicyclic 5-15 membered ring; more preferably aryl is phenyl; more preferably heteroaryl is 1-4 independently selected from O, N and S or a 9- to 10-membered heteroaromatic ring having 1-4 heteroatoms independently selected from O, N, and S; even more preferably , aryl is phenyl, and even more preferably heteroaryl is a 5-6 membered heteroaromatic ring having 1-4 heteroatoms independently selected from O, N, and S even more preferably heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl; indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; R. 7 and R 8 are hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, (C 3 -C 7 ) cycloalkyl, heterocyclyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 ) alkyl, benzyl, H 2 N(C 1 -C6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl; 7 and R 8 may contain a heteroatom selected from oxygen, sulfur and nitrogen together with the nitrogen atom to which they are attached, wherein said 3-10 membered ring is a halogen, hydroxyl, oxo , (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); R. a and R b is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 3 -C 7 )cycloalkyl, phenyl(C 0 -C 6 ) alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl; a and R b is a 3- to 7-membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen together with the nitrogen atom to which they are attached (wherein said 3- to 7-membered ring is (C 1 -C 6 ) optionally substituted with 1 to 3 substituents independently selected from alkyl); Ar 2 are aryl and heteroaryl (these are hydrogen, halogen, cyano, nitro, hydroxyl, -COR 9 , -CONR 9 R. 10 , -NHSO 2 R. 9 , -SO 2 NR 9 R. 10 , (C 1 -C 6 ) alkylthio-, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 9 R. 10 , tri(C 1 -C 6 ) alkylsilyl, (C 1 -C 6 ) haloalkylthio-, -SF 5 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, and heterocyclyl (C 0 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy); 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, or heterocyclyl (C 0 -C 6 )alkoxy is halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, -NR c R. d , R c R. d N(C 1 -C 6 ) alkyl, R c R. d N(C 1 -C 6 )alkoxy, -C(=O)NR c R. d , R c R. d NC(=O)(C 1 -C 6 ) alkoxy, benzyloxy, and cyano optionally substituted with 1 to 6 substituents independently selected from the group consisting of; preferably aryl is phenyl or naphthyl, preferably hetero Aryl is an unsaturated or partially saturated monocyclic or bicyclic 5- to 15-membered ring having 1-4 heteroatoms independently selected from O, N and S, or a carbonyl; aryl is phenyl, more preferably heteroaryl is a 5-6 membered ring having 1-4 heteroatoms independently selected from O, N and S, or O, N, is a 9- to 10-membered heteroaromatic ring having 1 to 4 heteroatoms independently selected from and S; even more preferably, aryl is phenyl; even more preferably, heteroaryl is is a 5- to 6-membered heteroaromatic ring having 1-4 heteroatoms independently selected from , O, N, and S; even more preferably, heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl, indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; R. 9 and R 10 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl;9 and R 10 may contain a heteroatom selected from oxygen, sulfur and nitrogen together with the nitrogen atom to which they are attached, wherein said 3-10 membered ring is a halogen, hydroxyl, oxo , (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); and R. c and R d is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl; c and R d may, together with the nitrogen atom to which they are attached, form a 3- to 7-membered ring which may contain heteroatoms selected from oxygen, sulfur, and nitrogen; or a pharmaceutically acceptable salt thereof;

[0012] [2] Compounds of formula (I) according to [1]: R. 1 and R 2 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, and (C 3 -C 7 ) independently selected from the group consisting of cycloalkyl; or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic ring; X is a chemical bond, -(C(R 5 )(R 6 )-(CH 2 ) m )-、-(C 3 -C 8 )cycloalkyl-, -CH=CH-, and -CH 2 selected from the group consisting of O-; m is 0, 1, 2, or 3; and R. 5 and R 6 are hydrogen, halogen, hydroxyl, and (C 1 -C 6 ) independently selected from the group consisting of: alkyl; or a pharmaceutically acceptable salt thereof;

[0013] [3] Compounds of formula (I) according to [1] or [2]: R. 1 and R 2 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, and (C 3 -C 7 ) independently selected from the group consisting of cycloalkyl; or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic ring; X is a chemical bond and -CR 5 R. 6 - is selected from the group consisting of; R. 5 and R 6 are hydrogen, halogen, hydroxyl, (C 1 -C 6 ) alkyl, and (C 1 -C 6 ) independently selected from the group consisting of alkoxy; q is 1, 2, or 3; r is 1, 2, or 3; s is 1, 2, or 3; Ar 1 is hydrogen, halogen, hydroxyl, cyano, -C(=O)R 7 , -C(=O)NR 7 R. 8 , -NR 7 R. 8 , -NHSO 2 R. 7 , -SO 2 NR 7 R. 8 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) aryl and heteroaryl optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy, phenyl, heteroaryl, phenoxy, and heterocyclyl; 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 )alkoxy, phenyl, heteroaryl, phenoxy, or heterocyclyl is halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, -NR a R. b , -C(=O)NR a R. b , and -C(=O)R a optionally substituted with 1 to 6 substituents independently selected from the group consisting of; R. 7 and R 8 are hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and (C 3 -C 7 ) independently selected from the group consisting of cycloalkyl; or R 7 and R 8 is a 3- to 7-membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen together with the nitrogen atom to which they are attached (wherein said 3- to 7-membered ring is halogen, hydroxyl, ( C. 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, and (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); R. a and R b is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and (C 3 -C 7 ) independently selected from the group consisting of cycloalkyl; or R a and R b may contain a heteroatom selected from oxygen, sulfur and nitrogen together with the nitrogen atom to which they are attached, wherein said 3- to 7-membered ring is independently from methyl and ethyl optionally substituted with 1 to 3 substituents selected from) may be formed; Ar 2 are aryl and heteroaryl (these are hydrogen, halogen, hydroxyl, cyano, -COR 9 , -CONR 9 R. 10 , -NHSO 2 R. 9 , -SO 2 NR 9 R. 10 , -NR 9 R. 10 , (C 1 -C 6 ) haloalkylthio-, -SF5 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy, phenyl, heteroaryl, phenoxy, and heterocyclyl; 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, phenyl, heteroaryl, phenoxy, or heterocyclyl is halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, -NR c R. d , and -C(=O)NR c R. d optionally substituted with 1 to 6 substituents independently selected from the group consisting of; and R. c and R d is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and hydroxy (C 1 -C 6 ) independently selected from the group consisting of alkyl; c and R d may, together with the nitrogen atom to which they are attached, form a 3- to 7-membered ring which may contain heteroatoms selected from oxygen, sulfur, and nitrogen; or a pharmaceutically acceptable salt thereof;

[0014] [4] The compound of formula (I) according to any one of [1] to [3]: R. 1 and R 2 is independently selected from the group consisting of hydrogen, methyl, and ethyl; or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 6-membered carbocyclic ring; Ar 1 is hydrogen, halogen, hydroxyl, cyano, -C(=O)R 7 , -C(=O)NR 7 R. 8 , -NR 7 R. 8 , -NHSO 2 R. 7 , -SO 2 NR 7 R. 8 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) alkoxy, phenyl, naphthyl, phenoxy, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzimidazolyl, indolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, phenoxy, pyrrolidinyl, independently selected from the group consisting of piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, and aziridinyl; 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) alkoxy, phenyl, phenoxy, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, imidazolyl, pyrazolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzimidazolyl, indolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, phenoxy, pyrrolidinyl, Piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydrofuranyl, oxetanyl, and aziridinyl are halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, and (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl; wherein said aryl is phenyl or naphthyl; wherein said heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl, is indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; R. 7 and R 8 are hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, and (C 3 -C 7 ) is cycloalkyl independently selected from the group consisting of; Ar 2 are aryl and heteroaryl (these are hydrogen, halogen, hydroxyl, cyano, -SCF 3 ,SCIENCE FICTION 5 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) independently from the group consisting of haloalkoxy, phenyl, naphthyl, phenoxy, pyridyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl, benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazolyl, and indolyl phenyl, naphthyl, phenoxy, pyridyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl , benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazolyl, or indolyl is hydrogen, halogen, hydroxyl, cyano, -SCF 3 ,SCIENCE FICTION 5 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, and (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkoxy; wherein said aryl is phenyl or naphthyl; wherein said heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl, is indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; or a pharmaceutically acceptable salt thereof;

[0015] [5] A compound of formula (I-a) below: [formation] During the ceremony, R. 1 and R 2 are hydrogen, hydroxyl, halogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, (C 3 -C 7 ) cycloalkyl, and phenyl (C 0 -C 4 ) alkyl (where the (C 3 -C 7 )cycloalkyl or phenyl(C 0 -C 4 ) alkyl is halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1-C 6 )alkoxy, and (C 1 -C 6 ) optionally substituted with 1 to 4 substituents independently selected from the group consisting of haloalkoxy); or R 1 and R 2 are, together with the atoms to which they are attached, 3- to 8-membered carbocyclic rings (wherein said 3- to 8-membered rings are halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); preferably R 1 and R 2 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, and (C 3 -C 7 ) independently selected from the group consisting of cycloalkyl; or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic ring; R. 3 are hydrogen, fluorine, methyl, ethyl, and (C 1 -C 6 ) independently selected from the group consisting of haloalkyl; 3 is independently selected from the group consisting of hydrogen, fluorine, and methyl; q is 1, 2, 3, or 4; preferably q is 1 or 2; r is 1, 2, 3, or 4; preferably r is 1 or 2; s is 1, 2, 3, or 4; preferably s is 1 or 2; Ar 1 are aryl and heteroaryl (these are hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R 7 , -C(=O)NR 7 R. 8 , -NHSO 2 R. 7 , -SO 2 NR 7 R. 8 , (C 1 -C 6 ) alkylthio-, (C 1 -C 6 ) haloalkylthio-, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 7 R. 8 , tri(C 1 -C 6 ) alkylsilyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkenyl, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, heterocyclyl (C 0 -C 6 ) alkoxy, heteroaryl (C 0 -C 6 ) alkoxy, and optionally substituted with 1 to 6 substituents independently selected from the group consisting of substituents Q); 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkenyl, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, heterocyclyl (C 0 -C 6 )alkoxy, or heteroaryl(C 0 -C 6 )alkoxy is halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, phenyl, -NR a R. b , R a R. b N(C 1 -C 6 ) alkyl, R a R. b N(C 1 -C 6 )alkoxy, -C(=O)NR a R. b , -C(=O)R a , -SO 2 (C 1 -C 6 ) alkyl, -SO 2 NR a R. b , and R a R. b NC(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy; 3 -C 7 ) cycloalkyl may be optionally substituted with hydroxyl or cyano; wherein substituent Q is [formation] [formation] where the substituent Q is halogen, hydroxyl, or (C 1 -C 6 ) optionally substituted with alkyl; Preferably, aryl is phenyl or naphthyl, preferably heteroaryl is an unsaturated or partially saturated heteroatom having 1 to 4 heteroatoms independently selected from O, N and S, or carbonyl monocyclic or bicyclic 5-15 membered ring; more preferably aryl is phenyl; more preferably heteroaryl is 1-4 independently selected from O, N and S or a 9- to 10-membered heteroaromatic ring having 1-4 heteroatoms independently selected from O, N, and S; even more preferably , aryl is phenyl, and even more preferably heteroaryl is a 5-6 membered heteroaromatic ring having 1-4 heteroatoms independently selected from O, N, and S even more preferably heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl; indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; R. 7 and R 8 are hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkyl, (C 3 -C 7 ) cycloalkyl, heterocyclyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6)haloalkoxy(C 1 -C 6 ) alkyl, benzyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl; 7 and R 8 may contain a heteroatom selected from oxygen, sulfur and nitrogen together with the nitrogen atom to which they are attached, wherein said 3-10 membered ring is a halogen, hydroxyl, oxo , (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); R. a and R b is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 3 -C 7 )cycloalkyl, phenyl(C 0 -C 6 ) alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl; a and R b is a 3- to 7-membered ring that may contain atoms selected from oxygen, sulfur, and nitrogen together with the nitrogen atom to which they are attached (wherein said 3- to 7-membered ring is (C 1 -C 6 ) optionally substituted with 1 to 3 substituents independently selected from alkyl); Ar 2 are aryl and heteroaryl (these are hydrogen, halogen, cyano, nitro, hydroxyl, -COR 9 , -CONR 9 R. 10 , -NHSO 2 R. 9 , -SO 2 NR 9 R. 10 , (C 1 -C 6 ) alkylthio, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 9 R. 10 , tri(C 1 -C 6 ) alkylsilyl, (C 1 -C 6 ) haloalkylthio-, -SF 5 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, and heterocyclyl (C 0 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy); 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 )alkoxy, aryl(C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, or heterocyclyl (C 0 -C 6 )alkoxy is halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, -NR c R. d , R c R. d N(C 1 -C 6 ) alkyl, R c R. d N(C 1 -C 6 )alkoxy, -C(=O)NR c R. d , R c R. d NC(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy, benzyloxy, and cyano; Preferably, aryl is phenyl or naphthyl, preferably heteroaryl is an unsaturated or partially saturated heteroatom having 1 to 4 heteroatoms independently selected from O, N and S, or carbonyl monocyclic or bicyclic 5-15 membered ring; more preferably aryl is phenyl; more preferably heteroaryl is 1-4 independently selected from O, N and S or a 9-10 membered heteroaromatic ring having 1-4 heteroatoms independently selected from O, N, and S; and More preferably, aryl is phenyl, and even more preferably, heteroaryl is a 5-6 membered heteroaromatic having 1-4 heteroatoms independently selected from O, N, and S. even more preferably heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl, indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; R. 9 and R 10 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl; 9 and R 10 may contain a heteroatom selected from oxygen, sulfur and nitrogen together with the nitrogen atom to which they are attached, wherein said 3-10 membered ring is a halogen, hydroxyl, oxo , (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); and R. c and R d is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )haloalkoxy(C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 )alkyl] 2 N(C 1 -C 6 ) independently selected from the group consisting of alkyl; c and R d may, together with the nitrogen atom to which they are attached, form a 3- to 7-membered ring which may contain heteroatoms selected from oxygen, sulfur, and nitrogen; or a pharmaceutically acceptable salt thereof;

[0016] [6] Compounds according to [1] to [5], selected from: (R)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; (S)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; (R)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (S)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; (R)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H) -on; 6-(2-(4-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H) -on; 2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(4-fluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; 6-(2-(4-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; 6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-(4-(tert-butyl)phenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-(5-fluoro-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-(benzo[d]isoxazol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; 6-(2-(5-methyl-2-phenyloxazol-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(quinoxalin-6-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 6-(2,2-difluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 6-(2-fluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-(2-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; 6-(2-(2-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; 6-(3-(1H-indol-3-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(3-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(1H-indazol-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 4-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl )ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one; (E)-6-(3-(3-chlorophenyl)acryloyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-((1R * ,2R * )-2-phenylcyclopropane-1-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-((1R * ,2R *)-2-(2,5-difluorophenyl)cyclopropane-1-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; (R)-6-(2-Hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; (R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (-)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (S)-6-(2-Hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-(4-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; (S)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; 6-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; 6-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; 6-(2-(2,6-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; (R)-6-(2-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-6-(2-hydroxy-4-phenylbutanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-Hydroxy-2-(6-methylpyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; 6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(2,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyride [4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyride [4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(naphthalen-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-Hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; (R)-4-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4, 3-d]pyrimidin-2-yl)cyclopropyl)benzonitrile; 4-(1-(6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3 -d]pyrimidin-2-yl)cyclopropyl)benzonitrile; (S)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyride [4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-isopropoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; (R)-2-(1-(2-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-(3-(cyclopentyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(trifluoromethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; 6-(2-(2,3-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; 6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-Hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; 6-(2-hydroxy-2-(3-(6-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 3-(1-Hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6( 4H)-yl)ethyl)benzonitrile; 6-(2-Hydroxy-2-(3-(pyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methoxypyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(1,3-dimethyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d] Pyrimidin-6(4H)-yl)ethyl)benzonitrile; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; (R)-2-(1-benzylcyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 2-(1-benzylcyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; 6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-methylthiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiazol-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-((R)-2-(3-chlorophenyl)-2-hydroxyacetyl)-2-((R / S)-1-phenylethyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4, 5-d]azepin-4-one; (R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4 ,5-d]azepin-4-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7-tetrahydro-4H-pyrrolo[3,4-d ] pyrimidine-4-one; (R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine -4(3H)-on; 7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine- 4(3H)-on; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; (R)-8-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[4,5-c]azepin-4-one; (R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4 ,5-c]azepin-4-one; 6-(2-hydroxy-2-(2-(pyrrolidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2-(piperidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-(azepan-1-yl)pyridin-4-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-5-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4, 3-d]pyrimidin-2-yl)cyclopropyl)thiophene-3-carbonitrile; 4-oxo-2-(1-phenylcyclopropyl)-N-(3-(trifluoromethyl)phenyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H )-carboxamide; 6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H) -on; 6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 2-Benzyl-6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H) -on; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(5-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-chloro-5-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-4-yl)thiophen-2-yl)cyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(2-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; (R)-2-(1-(4-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyride [4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl)cyclopropyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(4-hydroxy-2-naphthoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-Hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(2,3-dihydrobenzofuran-7-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-chloro-4-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-chloro-2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(3-(1H-indol-1-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-(5-chlorothiophen-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(4-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(4-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-6-(3-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(4-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; (R)-2-(1-(4-(1H-pyrazol-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; 6-(2-(4-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(5-(trifluoromethyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-1-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(naphthalen-1-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[4,5-c]azepin-4-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(6-(trifluoromethyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2-(trifluoromethyl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(6-chloro-1H-indole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H) -on; 2-(1-phenylcyclopropyl)-6-(5-(trifluoromethyl)-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(3-(2-fluorophenyl)-1H-pyrazole-5-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-(2-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(2-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; 2-(1-phenylcyclopropyl)-6-(2-(2-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(3-(3-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-3-(o-tryloxy)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-(3,4-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; 6-(2-(3-acetylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(3-ethylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-2-(1-(3-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(6-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; (R)-6-(2-hydroxy-2-(p-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ; 6-(2-(3-chloro-2-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorothiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-chlorothiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-4-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(naphthalen-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4 (3H)-on; 6-(2-(3-chloro-2-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(quinolin-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 2-(1-phenylcyclopropyl)-6-(2-(4-(pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(5-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(4-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-Hydroxy-2-(3-(6-methoxypyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methylpyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methylpyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(5-chlorothiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyride [4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-Hydroxy-2-(2-phenylpyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 6-(2-hydroxy-2-(1-methyl-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(2-methyl-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2-chloro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(5-chlorothiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-methyl-5-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 6-(2-hydroxy-2-(3'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 3'-(1-Hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6 (4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile; 6-(2-(4'-ethoxy-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(5,6-dimethylpyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyride [4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-(difluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-Cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(1-acetylpiperidin-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(6-chloropyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(6-(3-chlorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidin-4-yl)thiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(1-methylpiperidin-4-yl)thiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; 6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-acetylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-methoxyphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5, 4-c]azepin-4-one; 6-(2-(6-(Cyclohexen-1-en-1-yl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(1'-methyl-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-6-yl)acetyl)-2-(1- phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(6-Cyclohexylpyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(6-isopropylpyridin-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 6-(2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; 6-(2-amino-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-hydroxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-Cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazol-5-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methoxypropyl)thiophen-2-yl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(6-(3-(tert-butyl)phenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(tetrahydro-2H-pyran-4-yl)ethyl) Thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidin-5-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4', 5'-Tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-((R)-2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1-trifluoropropan-2-yl)phenyl ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-hydroxy-3-methylbutyl)thiophen-2-yl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; (R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethylthiophene-3-carboxamide; 1-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2 -(3-(trifluoromethyl)phenyl)ethane-1,2-dione; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(hydroxymethyl)phenyl)cyclopropyl)-3,5,6, 7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophene-2- yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(piperidin-1-ylmethyl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9) -hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)nicotinonitrile; (R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1′-biphenyl]-3-carboxamide; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-fluoro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5'-fluoro-2'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2',3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-([1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-bromopyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-Hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(4-(2-((3S,5S)-adamantan-1-yl)ethyl)thiophen-2-yl)cyclopropyl)-6-((RS)-2-hydroxy-2-( 3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethoxy)phenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-6-oxo-1,6-dihydropyridine-3) -yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3- (trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(5-(3-fluorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[3,4'-bipyridin]-5-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(6-(3-fluorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidine- 4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1′-biphenyl]-3-sulfonamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)- [11′-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl) )phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-3-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazole-4- yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1′-biphenyl]-4-sulfonamide; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxazol-5-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3 -yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-4-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isoindoline-2-carbonyl)thiophen-2-yl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4''-chloro-[1,1':4',1''-terphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoro) Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl) Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9) -hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3-methylbenzo[d]oxazol-2(3H)-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl ]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl] -3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridine-3) -yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperazin-1-yl)pyridine-3) -yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-((4-methylpiperazin-1-yl)methyl)-[ 1,1′-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-methoxypyridin-3-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-methylpiperidin-4-yl)-1H- pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(1-methylpiperidin-4-yl)-[1,1 '-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-Cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(thiazol-5-yl)thiophen-2-yl)cyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(tri fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl) Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine -4(3H)-on; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl ) cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl) Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyrrolidin-1-ylmethyl)-[1,1'-biphenyl ]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-Hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl) ) cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropyl-N-methylthiophene-3-carboxamide; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidine-1-carbonyl)thiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(3'-Fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-Hydroxy-2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4( 3H) - on; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(3'-Fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(quinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(isoquinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(quinolin-7-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(quinolin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9) -hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-N,N-dimethylnicotinamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(trifluoromethyl)cyclopropane-1-) carbonyl)-1.2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine- 4 - on; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxy Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[ 5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridine -3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2- Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazine-1-) yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9) -hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)picolinonitrile; (R)-2-(1-(4'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3- (trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl ]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 6-(2-(4-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyride [4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-Hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-2-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H -pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile; (R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[ 5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-sulfonamide; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(indolin-1-yl)acetyl)- 12,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7, 8,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-4-oxobutane acid; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3 ,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8) ,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1′-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide; (R)-6-(2-(3-(cyclopenten-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-1-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-2-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 8,8-difluoro-2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; (R)-N,N-dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7, 8,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; (R)-N-benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-diisopropylthiophene-3-carboxamide; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trans)-4-(trifluoromethyl)cyclohexane) -1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c ]azepine-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl) )-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4 -on; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methylindolin-5-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-(2-oxopyrrolidin-1-yl)) Propanoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine- 4 - on; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2 ,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; (R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2- (3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2- (3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2 -hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)phenyl)-2-hydroxyacetyl)-2-(1- phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(2,3-dihydrobenzofuran-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)) Cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; (R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)- 6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-N-Cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7 ,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide; (R)-3-Cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6) ,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-phenylpiperidin-1-yl)pyridine-3 -yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-( 3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-4-(2-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6) ,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)- 2-oxoethyl)benzoic acid; (R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7, 8,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)carbamoyl)bicyclo[2.2. 2] octane-1-carboxylic acid; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-(4-(phenoxymethyl)) Phenyl)acetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenyloxazol-5-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide; (R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6, 7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; (R)-N,N-dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7, 8,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide; (R)-N-(tert-butyl)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6, 7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-Cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-Cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-Chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro -6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl) )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclo Propyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine -4-on; (R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-( 2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyloxazolon-5-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenylthiazol-2-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d ]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl) Acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl) Acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6, 7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6, 7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoro) Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoro) Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-Cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8 ,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-3-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8 ,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1′-biphenyl]-4-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,4-dicarbonitrile; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl )-[1,1′-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8 ,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile; (R)-2-(1-(4-Cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-Cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-4-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-Cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-Cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2- Hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)- 2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-4-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-([1,1'-biphenyl]-3-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 6-([1,1'-biphenyl]-4-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-3-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4 -on; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(4-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4 -on; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 8-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[4,5-c]azepin-4-one; 2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(pentafluoro-(lambda)6-sulphanyl)phenyl)acetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-2-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; (E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; 5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1 ,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3 -yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1 ,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3 -yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'- biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'- biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1' -biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]- 3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepine -6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepine -6-yl)ethyl)-[1,1'-biphenyl]-4-carbonitrile; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5, 4-c]azepin-4-one; 5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)- yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 5-Chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6 (4H)-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; 6-(2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine- 4 - on; 6-(2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine- 4 - on; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c ]azepine-4-one; 6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c ]azepine-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenoxy)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; and (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(phenylethynyl)thiophen-2-yl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; or a pharmaceutically acceptable salt thereof.

[0017] [7] The compound of [6], selected from: (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[ 5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-( 3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-Chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro -6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidine- 4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; (R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H -pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-Cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7 ,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl) Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-Cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl] -3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)) Phenyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)- 2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-Cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1-trifluoropropan-2-yl)phenyl ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-methoxypyridin-3-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl ]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-Cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridine-3) -yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl ]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d ]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethoxy)phenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)- 6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(cyclopent-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoro) Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8 ,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl) Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-3-Cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6) ,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9) -hexahydro)-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)picolinonitrile; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenylthiazol-2-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trans)-4-(trifluoromethyl)cyclohexane) -1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c ]azepine-4-one; (R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9) -hexahydro)-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3-methylbenzo[d]oxazol-2(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; 5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3 -yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4', 5'-Tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4 -c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2- (3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl) )-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4 -on; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-Cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl) Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3 ,6)-Tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2- (3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl) )-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4 -on; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl) Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3 ,6)-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-4-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1′-biphenyl]-4-sulfonamide; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-Cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-( 2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6, 7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9) -hexahydro)-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)nicotinonitrile; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl) )phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)- [1,1′-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazole-4- yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepine -6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2- Hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2- (3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methylindolin-5-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclo Propyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine -4-on; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c ]azepine-4-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide; (R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6, 7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8) ,9)-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide ; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8 ,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1′-biphenyl]-3-carbonitrile; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl) Acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-Cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-2-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide; (R)-2-(1-(3-Cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(tri fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2 -hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxy Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl) ) cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; (R)-N,N-dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7, 8,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; 2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2- Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-Cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl )-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-Cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazol-5-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N,N-dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7, 8,9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5, 4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl) Acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(indolin-1-yl)acetyl)- 1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5 ,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-Cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] -3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methoxypropyl)thiophen-2-yl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8, 9-Hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro- 3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide; 6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9 - hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophene-2- yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoro) Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(trifluoromethyl)cyclopropane-1-) carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine- 4 - on; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoro) Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl ) acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3 -yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridine -3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyloxazol-5-yl)phenyl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c ]azepine-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]- 3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridine- 3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8, 9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)- 3,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2 ,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazine-1-) yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; (R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3, 5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1' -biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(3-(pentafluoro-(lambda)6-sulfanyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H- pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3- d]pyrimidine-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxazol-5-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4- c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1 ,1′]-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5, 6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro -4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6, 7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'- biphenyl)]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'- biphenyl)]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl )-[1,1′-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7, 8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl )-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8 -tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl) -3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1 ,1′]-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido [5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro -3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1′-biphenyl]-3-carboxamide; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6, 7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-5,6 ,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophene- 2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3 -yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro- 4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3 ,5,6,7,8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H -pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-( 3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7 ,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4, 3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-1-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[ 4,3-d]pyrimidin-4(3H)-one; 6-(2-(4''-chloro-[1,1':4',1''-terphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4 -c]azepine-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7, 8,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclo propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5, 6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-Hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4 ,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidin-5-yl)phenyl)cyclopropyl)-3,5 ,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8 ,9-Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-Cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro pyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6 ,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5 ,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[ 5,4-c]azepin-4-one; and 6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7 ,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; or a pharmaceutically acceptable salt thereof.

[0018] [8] A single enantiomer of a compound selected from the group consisting of: 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3 -d]pyrimidine-4(3H)-one; 6-(2-Hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H )-on; 6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidine-4(3H)-one; 2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d] Pyrimidin-6(4H)-yl)ethyl)benzonitrile; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine- 4(3H)-on; and 6-(2-Hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d ]pyrimidine-4(3H)-one; or a pharmaceutically acceptable salt thereof.

[0019] [9] A pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof according to any one of [1] to [8] and a pharmaceutically acceptable carrier;

[0020]

[10] The pharmaceutical composition of [9], further comprising another pharmacologically active agent;

[0021]

[11] A method of treating a condition or disorder mediated by TRPV4 receptor antagonistic activity in animals, including humans, comprising administering to the animal in need of such treatment a therapeutically effective amount of [1]-[8] or a pharmaceutically acceptable salt thereof;

[0022]

[12] The method of

[11] , wherein the condition or disorder is one or more selected from the group consisting of inflammation, pain, and urological diseases or disorders, and combinations thereof;

[0023]

[13] The condition or disorder is chronic pain; neuropathic pain, including diabetic neuropathy; postoperative pain; osteoarthritis; rheumatoid arthritis pain; Nerve injury; migraine; cluster and tension headaches; ischemia; irritable bowel syndrome; inflammatory bowel disease; neurodegeneration; fibromyalgia; inflammatory disorders, including asthma, chronic obstructive pulmonary disease (COPD) and chronic obstructive airway disease (COAD); pulmonary hypertension; and detrusor overactivity or overactive bladder, urinary incontinence, and nervous voiding urological diseases or disorders, including muscle overactivity or detrusor hyperreflexia, idiopathic detrusor overactivity or detrusor instability, benign prostatic hyperplasia, and lower urinary tract symptoms; and combinations thereof; The method of

[11] , which is one or more;

[0024]

[14] The compound of any one of [1] to [8], or a pharmaceutically acceptable salt thereof, for use in treating a condition or disorder mediated by TRPV4 receptor antagonistic activity;

[0025]

[15] The compound of any one of [1] to [8], or a pharmaceutically acceptable use of salts, solvates, or compositions thereof;

[0026]

[16] The use of

[15] , wherein the condition or disorder is one or more selected from the group consisting of inflammation, pain, and urological diseases or disorders, and combinations thereof;

[0027]

[17] The condition or disorder is chronic pain; neuropathic pain including diabetic neuropathy; postoperative pain; osteoarthritis; rheumatoid arthritis pain; Nerve injury; migraine; cluster and tension headaches; ischemia; irritable bowel syndrome; inflammatory bowel disease; neurodegeneration; fibromyalgia; inflammatory disorders, including asthma, chronic obstructive pulmonary disease (COPD) and chronic obstructive airway disease (COAD); pulmonary hypertension; and detrusor overactivity or overactive bladder, urinary incontinence, and nervous voiding urological diseases or disorders, including muscle overactivity or detrusor hyperreflexia, idiopathic detrusor overactivity or detrusor instability, benign prostatic hyperplasia, and lower urinary tract symptoms; and combinations thereof; a use according to

[15] , which is one or more;

[0028]

[18] A pharmaceutical comprising mixing the compound or a pharmaceutically acceptable salt thereof according to any one of [1] to [8] with a pharmaceutically acceptable carrier or excipient a method of making the composition;

[0029]

[19] A compound represented by the following formula (I-d): [formation] During the ceremony, R. 1 and R 2are hydrogen, hydroxyl, halogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 ) haloalkoxy, (C 3 -C 7 ) cycloalkyl, and phenyl (C 0 -C 4 ) alkyl (where the (C 3 -C 7 )cycloalkyl or phenyl(C 0 -C 4 ) alkyl is halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 )alkoxy, and (C 1 -C 6 ) optionally substituted with 1 to 4 substituents independently selected from the group consisting of haloalkoxy); or R 1 and R 2 is a 3- to 8-membered ring which, together with the atoms to which they are attached, may contain 0 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen (wherein said 3- to 8-membered ring are halogens, hydroxyls, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl); R. 3 are hydrogen, fluorine, methyl, ethyl, and (C 1 -C 6 ) independently selected from the group consisting of haloalkyl; q is 1, 2, 3, or 4; r is 1, 2, 3, or 4; s is 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof;

[0030]

[20] A compound selected from the group consisting of: (R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyri de[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,...

Claims

1. A compound of formula (I): 【Chemical 1】 During the ceremony, R 1 and R 2 is hydrogen and (C 1 -C 6 ) alkyl (only except that R 1 and R 2 are both hydrogen; or R 1 and R 2 together with the atoms to which they are attached form a 3- to 8-membered carbocyclic ring, wherein said 3- to 8-membered carbocyclic ring is free of halogen, hydroxyl, Roxyl, (C 1 -C 6 ) alkyl, and (C 1 -C 6 ) haloalkyl); R 3 are independently selected from the group consisting of hydrogen, fluorine, and methyl; X is a chemical bond, -N(R 4 )-, -(C(R 5 )(R 6 )) n -, -(C 3 -C 8 ) cycloalkyl-, -C(R 5 )=C(R 6 )-, -C(=O)-, -CR 4 (N(R 5 )(R 6 ))-, -[(C(R 5 )(R 6 )) n O]-, -[(C(R 5 )(R 6 )) n N(R 4 )]-, -[(C(R 5 )(R 6 )) n S]-, and -[N(R 4 )(C(R 5 )(R 6 )) n ]-; R 4 is hydrogen or (C 1 -C 6 ) alkyl; R 5 and R 6 is hydrogen, halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, hydroxyl (C 1 -C 6 ) alkyl, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and (C 1 -C 6 ) haloalkoxy; where R 5 If there are two or more, R 5 are the same or different; where R 6 If there are two or more, R 6 are the same or different; n is 1, 2, 3, or 4; q is 1, 2, 3, or 4; r is 1, 2, 3, or 4; s is 1, 2, 3, or 4; Ar 1 are aryl and heteroaryl (which are substituted with hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R 7 , -C(=O)NR 7 R 8 , -NHSO 2 R 7 , -SO 2 NR 7 R 8 , (C 1 -C 6 ) alkylthio-, (C 1 -C 6 ) haloalkylthio-, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 7 R 8 , Tori (C 1 -C 6 ) alkylsilyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) alkenyl, aryl (C 0 -C 4 )Al alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, heterocyclyl (C 0 -C 6 ) alkoxy, heteroaryl (C 0 -C 6 )Alkoxy and optionally substituted with 1 to 6 substituents independently selected from the group consisting of: may be selected from; Here, the above (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) alkenyl, aryl (C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) Alkyl, heterocyclo Lil (C 0 -C 6 ) alkoxy, or heteroaryl (C 0 -C 6 )Alkoxy is a group that includes halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkoxy, phenyl, -NR a R b , R a R b N(C 1 -C 6 ) alkyl, R a R b N(C 1 -C 6 ) alkoxy, -C(=O)NR a R b , -C(=O)R a , -SO 2 (C 1 -C 6 ) alkyl, -SO 2 NR a R b , and R a R b NC(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy wherein said (C 3 -C 7 ) Cycloalkyl is optionally hydroxyl or cyano. wherein the substituent Q is 【Chemistry 2】 【Chemistry 3】 where the substituent Q is halogen, hydroxyl, or (C 1 -C 6 ) optionally substituted with alkyl; R 7 and R 8 is hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) Haloalkyl, (C 1 -C 6 ) haloalkoxy, (C 3 -C 7 ) cycloalkyl, heterocyclyl, hydroxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) Alkyl, Benzyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl; or R 7 and R 8 are 3- to 10-membered rings which, together with the nitrogen atom to which they are attached, may contain heteroatoms selected from oxygen, sulfur, and nitrogen (wherein the 3- to 10-membered rings are not limited to halogen, hydroxyl, hydroxybenzoate ... Droxil, oxo, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) haloalkyl; may form a R a and R b is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy(C 1 -C 6 )a Lukil, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, phenyl (C 0 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )Al Kill NH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl or R a and R b are 3- to 7-membered rings which, together with the nitrogen atom to which they are attached, may contain heteroatoms selected from oxygen, sulfur, and nitrogen (wherein the 3- to 7-membered ring is (C 1 -C 6 ) alkyl); Ar 2 are aryl and heteroaryl (which are substituted with hydrogen, halogen, cyano, nitro, hydroxyl, -COR 9 , -CONR 9 R 10 , -NHSO 2 R 9 , -SO 2 NR 9 R 10 , (C 1 -C 6 ) alkylthio-, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 9 R 10 , Tori (C 1 -C 6 ) alkylsilyl, (C 1 -C 6 ) Haloalkylthio-, -SF 5 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) alkoxy, aryl (C 0 -C 4 ) Alkyl, heteroaryl Rule (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, and heterocyclyl (C 0 -C 6 ) Alcoki and optionally substituted with 1 to 6 substituents independently selected from the group consisting of wherein the (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) Cycloalco Kishi, (C 1 -C 6 ) alkoxy, aryl (C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl , aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, or heterocyclyl (C 0 -C 6 )Alkoxy is a group containing halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkoxy, -NR c R d , R c R d N(C 1 -C 6 ) alkyl, R c R d N(C 1 -C 6 ) alkoxy, -C(=O)NR c R d , R c R d NC(=O)(C 1 -C 6 ) Arco 1 to 6 independently selected from the group consisting of -C, ... and optionally substituted with a substituent of R 9 and R 10 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl; or R 9 and R 10 are those a 3- to 10-membered ring which, together with the nitrogen atom to which it is attached, may contain a heteroatom selected from oxygen, sulfur, and nitrogen, wherein said 3- to 10-membered ring is selected from halogen, hydroxyl, oxo, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) haloalkyl) and R c and R d is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy(C 1 -C 6 )a Lukil, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl; or R c and R d may, together with the nitrogen atom to which they are attached, form a 3- to 7-membered ring which may contain heteroatoms selected from oxygen, sulfur, and nitrogen; or a pharmaceutically acceptable salt thereof.

2. A compound of formula (I) according to claim 1, wherein: R 1 and R 2 is hydrogen and (C 1 -C 6 ) alkyl (only except that R 1 and R 2 are both hydrogen; or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic ring; X is a chemical bond, -(C(R 5 )(R 6 )-(CH 2 ) m )-, -(C 3 -C 8 ) cycloalkyl-, -CH=CH-, and -CH 2 O-; m is 0, 1, 2, or 3; and R 5 and R 6 is hydrogen, halogen, hydroxyl, and (C 1 -C 6 ) alkyl group are independently selected from; or a pharmaceutically acceptable salt thereof.

3. A compound of formula (I) according to claim 1 or claim 2, wherein: R 1 and R 2 is hydrogen and (C 1 -C 6 ) alkyl (only except that R 1 and R 2 are both hydrogen; or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic ring; X is a chemical bond and -CR 5 R 6 - selected from the group consisting of; R 5 and R 6 is hydrogen, halogen, hydroxyl, (C 1 -C 6 ) alkyl, and (C 1 -C 6 ) alkoxy; q is 1, 2, or 3; r is 1, 2, or 3; s is 1, 2, or 3; Ar 1 is hydrogen, halogen, hydroxyl, cyano, -C(=O)R 7 , -C(=O)NR 7 R 8 , -NR 7 R 8 , -NHSO 2 R 7 , -SO 2 NR 7 R 8 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) aryl and heteroaryl optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy, phenyl, heteroaryl, phenoxy, benzyloxy, and heterocyclyl; 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 )a Alkoxy, phenyl, heteroaryl, phenoxy, benzyloxy, or heterocyclyl are substituted with halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, -NR a R b , -C(=O)NR a R b , and -C(=O)R a from optionally substituted with 1 to 6 substituents independently selected from the group consisting of: R 7 and R 8 is hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and (C 3 -C 7 ) cycloalkyl; or R 7 and R 8 Ha, so a 3- to 7-membered ring which, together with the nitrogen atom to which it is attached, may contain heteroatoms selected from oxygen, sulfur, and nitrogen (wherein the 3- to 7-membered ring is not a halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, and (C 1 -C 6 ) haloalkyl); R a and R b is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and (C 3 -C 7 ) Cyclo alkyl; or R a and R b are 3- to 7-membered rings which, together with the nitrogen atom to which they are attached, may contain heteroatoms selected from oxygen, sulfur, and nitrogen, wherein said 3- to 7-membered rings contain 1 to 3 heteroatoms independently selected from methyl and ethyl; (which may be optionally substituted with a substituent of the formula: Ar 2 are aryl and heteroaryl (which are substituted with hydrogen, halogen, hydroxyl, cyano, -COR 9 , -CONR 9 R 10 , -NHSO 2 R 9 , -SO 2 NR 9 R 10 , -NR 9 R 10 , (C 1 -C 6 )Haloalkylthio- ,-SCIENCE FICTION 5 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy, phenyl, heteroaryl, phenoxy, benzyloxy, and heterocyclyl; wherein said (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) Cycloa Alkoxy, (C 1 -C 6 ) Alkoxy, phenyl, heteroaryl, phenoxy, benzyloxy The cycloalkyl or heterocyclyl is substituted with halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkoxy, -NR c R d , and -C(=O)NR c R d and R c and R d is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, and hydroxy (C 1 -C 6 ) alkyl; or R c and R d are combined together with the nitrogen atom to which it is attached, may form a 3- to 7-membered ring which may contain heteroatoms selected from oxygen, sulfur, and nitrogen; or a pharmaceutically acceptable salt thereof.

4. A compound of formula (I) according to any one of claims 1 to 3, wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, methyl, and ethyl (except when R 1 and R 2 are both hydrogen); or R 1 and R 2 may, together with the atoms to which they are attached, form a 3- to 6-membered carbocyclic ring; Ar 1 are aryl and heteroaryl (which are substituted with hydrogen, halogen, hydroxyl, Cyano, -C(=O)R 7 , -C(=O)NR 7 R 8 , -NR 7 R 8 , -NHSO 2 R 7 , -SO 2 NR 7 R 8 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) Alkoxy, phenyl, naphthyl, phenoxy, benzyl and optionally substituted with 1 to 6 substituents independently selected from the group consisting of oxy, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzothiazolyl, indazolyl, benzimidazolyl, indolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, and aziridinyl; 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) Alkoxy, phenyl, naphthyl, phenoxy, benzyloxy, pyridinyl aryl, pyrimidinyl, pyridazinyl, pyrazinyl, imidazolyl, pyrazolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzothiazolyl, indazolyl, benzimidazolyl, indolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydrofuranyl, oxetanyl, or aziridinyl is substituted or unsubstituted by halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, and (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkyl; wherein said aryl is phenyl or naphthyl; wherein said heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl, indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; R 7 and R 8 is hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) Haloalkyl, (C 1 -C 6 ) haloalkoxy, and (C 3 -C 7 ) cycloalkyl; Ar 2 are aryl and heteroaryl (which are hydrogen, halogen, hydroxyl, cyano, -SCF 3 ,SCIENCE FICTION 5 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkoxy, phenyl, naphthyl, phenoxy, benzyloxy, pyridinyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl, benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazolyl, and indolyl; wherein said phenyl, Naphthyl, phenoxy, benzyloxy, pyridinyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl, benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazolyl, or indolyl are substituted with hydrogen, halogen, hydroxyl, cyano, -SCF 3 ,SCIENCE FICTION 5 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, and (C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of haloalkoxy; wherein said aryl is phenyl or naphthyl; wherein said heteroaryl is pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazopyridinyl, indazolyl, oxadiazolyl, benzisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl; or a pharmaceutically acceptable salt thereof.

5. A compound of formula (Ia) below: 【Chemistry 4】 During the ceremony, R 1 and R 2 is hydrogen and (C 1 -C 6 ) alkyl (only except that R 1 and R 2 are both hydrogen; or R 1 and R 2 together with the atoms to which they are attached form a 3- to 8-membered carbocyclic ring, wherein said 3- to 8-membered ring is free of halogen, hydroxyl, Lu, (C 1 -C 6 ) alkyl, and (C 1 -C 6 ) one independently selected from the group consisting of haloalkyl optionally substituted with up to 6 substituents; R 3 are independently selected from the group consisting of hydrogen, fluorine, and methyl; q is 1, 2, 3, or 4; r is 1, 2, 3, or 4; s is 1, 2, 3, or 4; Ar 1 are aryl and heteroaryl (which are substituted with hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R 7 , -C(=O)NR 7 R 8 , -NHSO 2 R 7 , -SO 2 NR 7 R 8 , (C 1 -C 6 ) alkylthio-, (C 1 -C 6 ) haloalkylthio-, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 7 R 8 , Tori (C 1 -C 6 ) alkylsilyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) alkenyl, aryl (C 0 -C 4 )Al alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, heterocyclyl (C 0 -C 6 ) alkoxy, heteroaryl (C 0 -C 6 )Alkoxy and optionally substituted with 1 to 6 substituents independently selected from the group consisting of: may be selected from; Here, the above (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) alkenyl, aryl (C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, heterocyclic Krill (C 0 -C 6 ) alkoxy, or heteroaryl (C 0 -C 6 )Alkoxy is a group that includes halogen, hydroxyl, cyano, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkoxy, phenyl, -NR a R b , R a R b N(C 1 -C 6 ) alkyl, R a R b N(C 1 -C 6 ) alkoxy, -C(=O)NR a R b , -C(=O)R a , -SO 2 (C 1 -C 6 ) alkyl, -SO 2 NR a R b , and R a R b NC(=O)(C 1 -C 6 ) optionally substituted with 1 to 6 substituents independently selected from the group consisting of alkoxy; wherein said (C 3 -C 7 ) Cycloalkyl is hydroxyl or cyano. and optionally substituted; wherein the substituent Q is 【Chemistry 5】 【Chemistry 6】 where the substituent Q is halogen, hydroxyl, or (C 1 -C 6 ) optionally substituted with alkyl; R 7 and R 8 is hydrogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) Haloalkyl, (C 3 -C 7 ) cycloalkyl, heterocyclyl, hydroxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) Alkyl, Benzyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl; or R 7 and R 8 are 3- to 10-membered rings which, together with the nitrogen atom to which they are attached, may contain heteroatoms selected from oxygen, sulfur, and nitrogen (wherein said 3- to 10-membered rings are not limited to halogen, hydroxyl, oxo, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) haloalkyl) ； R a and R b is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy(C 1 -C 6 )a Lukil, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, phenyl (C 0 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 )Al Kill NH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl or R a and R b are 3- to 7-membered rings which, together with the nitrogen atom to which they are attached, may contain an atom selected from oxygen, sulfur, and nitrogen (wherein said 3- to 7-membered rings is (C 1 -C 6 ) alkyl); Ar 2 are aryl and heteroaryl (which are substituted with hydrogen, halogen, cyano, nitro, hydroxyl, -COR 9 , -CONR 9 R 10 , -NHSO 2 R 9 , -SO 2 NR 9 R 10 , (C 1 -C 6 ) alkylthio, (C 1 -C 6 ) alkylsulfinyl, (C 1 -C 6 ) alkylsulfonyl, -NR 9 R 10 , Tori (C 1 -C 6 ) alkyl Cyril, (C 1 -C 6 ) Haloalkylthio-, -SF 5 , (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) cycloalkoxy, (C 1 -C 6 ) alkoxy, aryl (C 0 -C 4 ) Alkyl, heteroaryl Rule (C 0 -C 4 ) alkyl, aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, and heterocyclyl (C 0 -C 6 ) Alcoki and optionally substituted with 1 to 6 substituents independently selected from the group consisting of wherein the (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 3 -C 7 ) Cycloalco Kishi, (C 1 -C 6 ) alkoxy, aryl (C 0 -C 4 ) alkyl, heteroaryl (C 0 -C 4 ) alkyl , aryl (C 0 -C 6 ) alkoxy, phenoxy, heteroaryl (C 0 -C 6 ) alkoxy, heterocyclyl (C 0 -C 4 ) alkyl, or heterocyclyl (C 0 -C 6 )Alkoxy is a group containing halogen, hydroxyl, (C 1 -C 6 ) alkyl, (C 3 -C 7 ) cycloalkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkoxy, -NR c R d , R c R d N(C 1 -C 6 ) alkyl, R c R d N(C 1 -C 6 ) alkoxy, -C(=O)NR c R d , R c R d NC(=O)(C 1 -C 6 ) Arco optionally substituted with 1 to 6 substituents independently selected from the group consisting of -oxy, benzyloxy, cyano, and -SF3; R 9 and R 10 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy(C 1 -C 6 ) alkyl, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl; or R 9 and R 10 are those a 3- to 10-membered ring which, together with the nitrogen atom to which it is attached, may contain a heteroatom selected from oxygen, sulfur, and nitrogen, wherein said 3- to 10-membered ring is selected from halogen, hydroxyl, oxo, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, -SO 2 (C 1 -C 6 ) alkyl, -SO 2 (C 1 -C 6 ) haloalkyl, -C(=O)(C 1 -C 6 ) alkyl, and -C(=O)(C 1 -C 6 ) haloalkyl) and R c and R d is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, hydroxy(C 1 -C 6 )a Lukil, (C 1 -C 6 )Alkoxy(C 1 -C 6 ) alkyl, (C 1 -C 6 ) Haloalkoxy (C 1 -C 6 ) alkyl, H 2 N(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylNH(C 1 -C 6 ) alkyl, and [(C 1 -C 6 ) alkyl] 2 N(C 1 -C 6 ) alkyl; or R c and R d may, together with the nitrogen atom to which they are attached, form a 3- to 7-membered ring which may contain heteroatoms selected from oxygen, sulfur, and nitrogen; or a pharmaceutically acceptable salt thereof.

6. A compound according to claims 1 to 5 selected from: (R)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-fluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-(tert-butyl)phenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-fluoro-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(benzo[d]isoxazol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-methyl-2-phenyloxazol-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(quinoxalin-6-yl)acetyl)-5,6,7,8-tetramethyl Hydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrafluoroethylene Lahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-fluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydrofuran Dropirido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(1H-indol-3-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(1H-indazol-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 4-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one; (E)-6-(3-(3-chlorophenyl)acryloyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-((1R * ,2R * )-2-phenylcyclopropane-1-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-((1R * ,2R * )-2-(2,5-difluorophenyl)cyclopropane-1-carbonyl)-2-(1-phenyl (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydrofuran tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclohexyl)-2-hydroxybenzoate Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclohexyl)-2-hydroxyacetyl)-2-(1-phenylcyclohexyl)-2-hydroxybenzoate Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2- Hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (-)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetate r)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydrofuran tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,6-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-4-phenylbutanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(6-methylpyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclohexyl) Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxy Diacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclo Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(3,5-difluorophenyl)-2-hydroxy Diacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclo Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclohexyl) (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclohexyl) (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclohexane Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclohexyl) (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclohexyl) (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(naphthalen-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydrofuran Lahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-4-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexachlorophenyl)-4-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexachlorophenyl benzonitrile; 4-(1-(6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8- Hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)benzonitrile; (S)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydro (roxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclohexyl) (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydro (roxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydro (roxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropane) propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-isopropoxyphenyl)acetyl)-2-(1-phenylcyclopropyl) r)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(2-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydro (roxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-chlorophenyl)cyclo Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(cyclopentyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclohexyl) (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(trifluoromethoxy)phenyl)acetyl)-2-(1-phenylcyclohexane (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenyl (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclohexane Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl) (phenyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylacetyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl ... (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluorophenyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluorophenyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Methyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydrofuran Lahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl) r)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(6-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile; 6-(2-hydroxy-2-(3-(pyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methoxypyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(1,3-dimethyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-methylthiazol-4-yl)-2-methylthiazol-4-yl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiazol-2-yl)-2-isothiazol-2-yl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiophene-2-yl)- (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophene-2- (yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-((R)-2-(3-chlorophenyl)-2-hydroxyacetyl)-2-((R / S)-1-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one; (R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7-tetrahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one; (R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one; 7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl) Pyr)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl) Pyr)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 6-(2-hydroxy-2-(2-(pyrrolidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2-(piperidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-(azepan-1-yl)pyridin-4-yl)-2-hydroxyacetyl)-2-(1-phenylsilyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexachlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexachlorophenyl 2-Hydroxypyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)thiophene-3-carbonite Lil; 4-oxo-2-(1-phenylcyclopropyl)-N-(3-(trifluoromethyl)phenyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxamide; 6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylacetyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(5-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-5-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-4-yl)thio) (phen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thio) (phen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2- Hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyra) ... (4-phenyl-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pi Rimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclohexyl) (propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluorophenyl)-2-methyl ... Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(1-methyl-1H-pyrazoline)- (4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pi Rimidin-4(3H)-one; 6-(4-hydroxy-2-naphthoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydro Pyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclohexane Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3-dihydrobenzofuran-7-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-4-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(1H-indol-1-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-chlorothiophen-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(3-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropanediol) propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetramethyl tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(1H-pyrazol-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(5-(trifluoromethyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-1-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylacetyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(6-(trifluoromethyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2-(trifluoromethyl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(6-chloro-1H-indole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrachloro-1H-indole tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(5-(trifluoromethyl)-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(2-fluorophenyl)-1H-pyrazole-5-carbonyl)-2-(1-phenylcyclopropyl) r)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(2-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(2-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(3-(3-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-3-(o-tolyloxy)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3,4-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-acetylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-ethylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(6-phenylpyridin-3-yl)-2-hydroxyacetyl)- (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxy Acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(p-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8- Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)- (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorothiophene-2-yl)- (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-chlorothiophene-2-yl)- (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxybenzoate) (hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxy Acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-4-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxybenzoate) (hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(naphthalen-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(quinolin-3-yl)acetyl)-5,6,7,8-tetrahydro lopirido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(4-(pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(5-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(4-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(6-methoxypyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylsilyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylsilyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methylpyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-methylpyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(5-chlorothiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- Fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiazolinone) (2-phen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-( Lambda)6-sulfanayl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro- Muda)6-sulfanayl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; 6-(2-hydroxy-2-(2-phenylpyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(1-methyl-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(2-methyl-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-chloro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiazolinone) (2-Ophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)silyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 6-(2-hydroxy-2-(3'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylsilyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylsilyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(5-chlorothiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-methyl-5-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydrofuran) (4,3-d)pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile Trill; 6-(2-(4'-ethoxy-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenyl) (phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(5,6-dimethylpyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(4'-(difluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1- 6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1- 6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-triphenyl)-2-methyl-2-propanol (fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepam Pin-4-on; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclohexyl) (isopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclohexyl) (propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- Fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-( Lambda)6-sulfanayl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropanediol) propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclohexyl) Propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl) (phenyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydro (oxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl) 1H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro- Muda)6-sulfanayl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl) (phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(1-acetylpiperidin-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; 6-(2-(6-chloropyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(6-(3-chlorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl ... (ethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo Propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidinyl)phenyl)-2-hydroxy- ... (Zin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(1-methyl) (piperidin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydro (xyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetone (ethyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-acetylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl-2-(2-hydroxyphenyl)-2-methyl ... Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-methoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(6-(cyclohexen-1-en-1-yl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenyl (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(1'-methyl-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-6-yl) Acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydro (hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(6-cyclohexylpyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2,2,2-trifluoromethyl)phenyl)-2,2,2-trifluoromethyl)-2,2,2-trifluoromethyl Ethoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(6-isopropylpyridin-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-phenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-amino-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl) Pyr)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylcyclohexane Propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-hydroxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl) (phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrid Mydin-4(3H)-one; 6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl-2-phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepam Pin-4-on; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazolinone) (phenyl-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methylphenyl)-2-hydroxyphenyl)-2-methyl ... (Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-(6-(3-(tert-butyl)phenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylsilyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9- Hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy 2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridinyl) (phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidinyl ... (Zin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrazol-4-yl Rimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazolinone) Azol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1- Trifluoropropan-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-hydroxyphenyl) (hydroxy-3-methylbutyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy 2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-N-Benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cycloproline Pyr)thiophene-3-carboxamide; (R)-N-Benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cycloproline Pyr)-N-methylthiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethylthiophene-3-carboxamide; 1-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-(3-(trifluoromethyl)phenyl)ethane-1,2-dione; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(hydro (Oxymethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetone (ethyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl) (yl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl) (yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)acetyl)- (fluoromethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(piperidinyl)phenyl)- ... (Zin-1-ylmethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo So-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl (phenyl)nicotinonitrile; (R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxybenzoyl) hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N- Dimethyl-[1,1'-biphenyl]-3-carboxamide; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridine-3- (yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； 6-(2-(3'-fluoro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(3'-fluoro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(5'-fluoro-2'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(2',3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(2'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-([1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl) r)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-bromopyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5- Isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(4-(2-((3S,5S)-adamantan-1-yl)ethyl)thiophen-2-yl)cyclopropyl)-6-((RS)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridinyl) (3-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)acetyl)- (fluoromethoxy)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-meth (4-pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (6-oxo-1,6-dihydropyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9- oxahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydroxy Doro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(5-(3-fluorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[3,4'-bipyridin]-5-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(6-(3-fluorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-sulfonamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)-[11'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (1H-pyrazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrazol- Rimid[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (phenyl-1H-pyrazol-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrazol-3-yl Rimid[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2- Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N- Dimethyl-[1,1'-biphenyl]-4-sulfonamide; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylsilyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxa (5-zol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridinyl) (4-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5- Isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-Cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline) Cetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-N-Benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cycloproline Pyr)-N-isopropylthiophene-3-carboxamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isopropyl)phenyl)- ... Endrine-2-carbonyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxy Acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2,3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (Nylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxy (Ciacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydride rho-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; (R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo So-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl (phenyl)-3-methylbenzo[d]oxazol-2(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1- 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl) Acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5- Phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5- Phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexyl Sahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexyl Sahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-((4- ... Tylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-meth (3-pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(1-methylpiperidin-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; thion-4(3H)-one; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-triphenyl)phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepam Pin-4-on; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- Isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(thiazol-5-yl)thiazol-2-yl)thiazol-2-yl)-2-hydroxyacetyl (2-phen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridinyl) (phenyl-3-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pi Rimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)-2-phenyl)-2-propanol) (fluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazolinone) Azol-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydro Oxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Rimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-phenoxyphenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl) pyr)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophene-2- (yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thio) (phen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxy Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxybenzoate) (hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)-2-hydroxyacetyl)- (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(tetrahydro-2H-pyra) ... (4-phenyl-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyridin Mydin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(tetra ... Hydro-2H-pyran-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetra ... Hydro-2H-pyran-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyran Rimid[5,4-c]azepin-4-one; (R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxybenzoate) (hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyrrolidin-1-ylmethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1- 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexane)-2-yl)-2-hydroxy-1-methyl-2-propanol) (Hexyl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetra ... Hydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridinyl) (phenyl-3-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetra ... Hydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)silyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropyl-N-methylthiophene-3-carboxamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidinyl)phenyl)-2-hydroxy- ... Zine-1-carbonyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-quinolin-3-yl)phenyl)- (phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-quinolin-3-yl)phenyl)- (phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclo (hexyl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2- Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyridine Do[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (Nylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (Nylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl) (1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)-2-hydroxyacetyl)- (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-triphenyl)phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetra ... hydro-2H-pyran-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl-2-phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridinyl) (phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazolinone) Azol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)silyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophene) (phenyl-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4- Isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropyl thiazolinone) (2-Ophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) (1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) (1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 1-(1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 1-(4-isopropylthiophen-2-yl)cyclopropyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophene) (phenyl-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4- Isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] Pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropyl thiazolinone) (2-phen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfanayl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyridine Do[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl 1-(1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl) 1-(1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(quinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(isoquinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(quinolin-7-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(quinolin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydro (oxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl (1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl) Pyr)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo So-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl (phenyl)-N,N-dimethylnicotinamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-( Trifluoromethyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-4-(2-chlorophenyl) ...3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-3-yl) (nyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H- (pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyra) ... (4-phenyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-methyl- (nyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo So-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl (phenyl)picolinonitrile; (R)-2-(1-(4'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydroxy Doro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyridyl Mydin-4(3H)-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl) 1-(5-isopropylpyridin-3-yl)cyclopropyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridin Mido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 1-(5-isopropylpyridin-3-yl)cyclopropyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- (Isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5- Phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridine-3- (yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) (1-(3-isopropylphenyl)cyclopropyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 1-(1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-2-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazoline) (4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-methyl-2-propanol) (phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazoline) (phenyl-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile; (R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-sulfonamide; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclo (Hexyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-( Indolin-1-yl)acetyl)-12,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridinyl Rimid[5,4-c]azepin-4-one; (R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-4-oxobutanoic acid; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-phenoxypyridine-4- (yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazolinone) Azol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazolinone) Azol-4-yl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridinyl) (3-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylphenyl) Lysin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-hydroxyphenyl)-4-methyl-2 ... hexo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide; (R)-6-(2-(3-(cyclopenten-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalene) (1-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalene) (2-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 8,8-difluoro-2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-N,N-Dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetate) (ethyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; (R)-N-Benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)a Cetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-diisopropylthiophene-3-carboxamide; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trifluoromethyl)phenyl)acetyl) trans)-4-(trifluoromethyl)cyclohexane-1-carbonyl)-1,2,3,6-tetrahydro Pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (5-indoline)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-(2-oxopyrrolidin-1-yl)propanoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropan-1 propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetate 1H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridine-4- (yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-(3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)phenyl)-2-hydro (hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)- (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropyl Thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropyl Pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridine) Zin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-methyl-2-benzo[b]thiophen-2-yl)phenyl)cyclopropyl) (phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)-2-hydroxyacetyl)- Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(2'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(2,3-dihydrobenzofuran-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1- (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one hmm; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydro Pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydrofuran) 6-(2-hydroxy-2-(3-(trifluoromethyl-4-pyridin-4-yl)phenyl)cyclopropyl)- ... Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)—N-cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide; (R)-3-Cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) (I)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-phenylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9- oxahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl) chloropropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-4-(2-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl (1,1'-biphenyl)-4-yl)methyl)(methyl)amino)-2-oxoethyl)benzoic acid; (R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)carbamoyl)bicyclo[2.2.2]octane-1- Carboxylic acid; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-(4-(phenoxymethyl)phenyl)acetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]phenyl)-2,3'-biphenyl ... Nyl)-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydro (xyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxy Acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5 ... (fluoromethyl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenyloxazol-5-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-N-Cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline) Cetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide; (R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl) Phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; (R)-N,N-Dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl) Cyclopropyl)thiophene-3-carboxamide; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide; (R)—N-(tert-butyl)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3- (yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]phenyl)-2,3'-difluoro ... [phenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trimethylsilyl ... Fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2- (S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylacetyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl ... (ethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenanthroline] nyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3- (yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclo (Hexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyl)-2-hydroxyphenyl)-2-(1-(3-(trifluoromethyl)phenyl)-2 ... (5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridinyl Rimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenyl) (2-( ... Mido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyridin Mydin-4(3H)-one; (R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1'- Biphenyl]-3-carbonitrile; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydro Oxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Rimid[5,4-c]azepin-4-one; (R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydro Oxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Rimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-3-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,4-dicarbonitrile; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexa Hydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] Phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorofluoro) (phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; 6-(2-([1,1'-biphenyl]-4-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridin Rimid[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexachlorophenyl) 6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl] phenyl]-3-carbonitrile; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexachlorophenyl) 6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl] phenyl]-4-carbonitrile; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; 6-(2-([1,1'-biphenyl]-4-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-([1,1'-biphenyl]-3-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-([1,1'-biphenyl]-4-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-3-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(4-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； 2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 8-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3- (yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophene) (2-phenyl-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl) (I)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-pentafluoro-(lambda)6-sulfonyl) aneil)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-2-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromo (phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexafluoro Sahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)phenyl)-2-methyl- (1,1'-biphenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9- oxahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexa Hydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydride rho-4H-pyrimido[5,4-c]azepin-4-one; 3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonyl Trill; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl] Phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-4-carbonitrile; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3- (yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexyl) (6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile Trill; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] Phenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyridine Do[4,3-d]pyrimidin-6(4H)-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl] Phenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropanediol) propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; 6-(2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenoxy)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; and (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(phenyl) (ethynyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidinyl Do[5,4-c]azepin-4-one; or a pharmaceutically acceptable salt thereof.

7. The compound of claim 6, selected from: (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)silyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropyl thiazolinone) (2-Ophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazoline) (phenyl-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl) (1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxybenzoate) (hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazolinone) Azol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl) chloropropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl) 1-(1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-meth (4-pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenanthroline] nyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexachlorophenyl) 6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl] phenyl]-4-carbonitrile; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclohexyl) (propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)acetyl)- (fluoromethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)—N-cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridine-3- (yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazolinone) Azol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydride rho-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydro (xyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophene-2- (yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl) (phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazoline) (4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) (1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)phenyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridin Rimid[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)-2-hydroxyacetyl)- Phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1- Trifluoropropan-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-meth (3-pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-triphenyl)phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepam Pin-4-on; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridinyl) (phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-methyl-2-propanol) (phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropyl thiazolinone) (2-phen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; (R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexyl Sahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl) (yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1'- Biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)acetyl)- (fluoromethoxy)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydrofuran) 6-(2-hydroxy-2-(3-(trifluoromethyl-4-pyridin-4-yl)phenyl)cyclopropyl)- ... Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(cyclopent-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiazolinone) (2-Ophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclo (Hexyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2- Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxybenzoyl) hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)- (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-3-Cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) (I)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 1-(1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo so-4,5,6,7,8,9-hexahydro)-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)picolinonitrile; (R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydro (oxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexachlorophenyl) 6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl] phenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenyl) (2-( ... Mido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridinyl Rimid[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2- 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5- Phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trifluoromethyl)phenyl)acetyl) trans)-4-(trifluoromethyl)cyclohexane-1-carbonyl)-1,2,3,6-tetrahydro Pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo so-4,5,6,7,8,9-hexahydro)-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3-methylbenzo[d]oxazol-2(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclohexyl) Propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) (1-(3-isopropylphenyl)cyclopropyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridinyl) (3-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl-2-phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridine) Zin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 1-(4-isopropylthiophen-2-yl)cyclopropyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- Isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-N-Benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cycloproline Pyr)-N-isopropylthiophene-3-carboxamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexyl) (6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile Trill; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- Fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-methyl-2-benzo[b]thiophen-2-yl)phenyl)cyclopropyl) (phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazolinone) Azol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy 2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl ... (ethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5- Isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetra ... hydro-2H-pyran-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl-2-phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepam Pin-4-on; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3,6)-tetrahydropyridin-4-yl)phenyl)cyclopropyl 1H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- Fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-methyl-2-benzo[b]thiophen-2-yl)phenyl)cyclopropyl) (phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazolinone) Azol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy 2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl ... (ethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5- Isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetra ... hydro-2H-pyran-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl-2-phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepam Pin-4-on; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3,6)-tetrahydropyridin-4-yl)phenyl)cyclopropyl 1H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridinyl) (4-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N- Dimethyl-[1,1'-biphenyl]-4-sulfonamide; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H- (pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trimethylsilyl ... Fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5- Phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropyl Thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3- (yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3- (yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)silyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo so-4,5,6,7,8,9-hexahydro)-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)nicotinonitrile; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5- Phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin Zin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1- (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Zin-4(3H)-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-triphenyl)phenyl)-2-propanol (fluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-quinolin-3-yl)phenyl)- (phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl (1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydro Oxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Rimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4(3H)- on; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophene) (phenyl-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]phenyl)-2,3'-difluoro ... [phenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; (R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-4-(2-chlorophenyl) ...3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-3-yl) (nyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonyl Trill; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetra ... Hydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy 2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetate 1H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxy (Ciacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4- Isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetra ... Hydro-2H-pyran-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyran Rimid[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (5-indoline)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; (R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide; (R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl) Phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-quinolin-3-yl)phenyl)- (phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyridin Mydin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophene) (2-phenyl-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-hydroxyphenyl)-4-methyl-2 ... hexo-4,5,6,7,8,9)-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-Benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)a Cetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalene) (2-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N-Cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline) Cetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl) 1-(5-isopropylpyridin-3-yl)cyclopropyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1- (phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridine-4- (yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-methyl- (nyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N,N-Dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetate) (ethyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide; 2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]phenyl)-2,3'-biphenyl ... Nyl)-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylsilyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydro (xyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorofluoro) (phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4-ol hmm; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazolinone) (phenyl-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-N,N-Dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl) Cyclopropyl)thiophene-3-carboxamide; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxy Acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)- (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)-2-hydroxyacetyl)- (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridinyl) (3-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexane)-2-yl)-2-hydroxy-1-methyl-2-propanol) (Hexyl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromo (phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetone (ethyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-( Indolin-1-yl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclo Propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-N-Cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)azoline) Cetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl) (I)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin thion-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-triphenyl)-2-methyl-2-propanol (fluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepam Pin-4-on; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenyl (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyridyl Mydin-4(3H)-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl] Phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclo (Hexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methylphenyl)-2-hydroxyphenyl)-2-methyl ... (Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridin Rimid[5,4-c]azepin-4-one; (R)-N-Benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cycloproline Pyr)-N-methylthiophene-3-carboxamide; (R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide; 6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5 ... (fluoromethyl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydro Oxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Rimid[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-( Trifluoromethyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridine-4- (yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydro Oxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Rimid[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo Propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophene) (phenyl-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pi Rimid[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridinyl) (phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (1H-pyrazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrazol- Rimid[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyl)-2-hydroxyphenyl)-2-(1-(3-(trifluoromethyl)phenyl)-2 ... (5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Rimid[5,4-c]azepin-4-one; 6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydride rho-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyridin Mido[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl) (1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrazol-4-yl Rimid[5,4-c]azepin-4-one; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4- Isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d] Pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyra) ... (4-phenyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropan-1 propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexa Hydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3- (Isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(pentafluoro-(lambda)6-sulfanyl)phenyl)acetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1- 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) (cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl) (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] Phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c] Azepin-4-one; (R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxybenzoate) (hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3- (yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxa (5-zol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1']-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-( λ) 6-sulfanyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl) Acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； (R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl) 1-(5-isopropylpyridin-3-yl)cyclopropyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; 6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydro (hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1- (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Methyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl)]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl)]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydride rho-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydride rho-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(pentafluoro-(λ)6-sulfanilic acid) (phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2- Hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyridine Do[4,3-d]pyrimidin-4(3H)-one; 6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl) (yl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylphenyl) Lysin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl] Phenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; (R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1']-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)silyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-o hmm; 2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N- Dimethyl-[1,1'-biphenyl]-3-carboxamide; 6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropyl Pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]aze Pin-4-on; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclo (hexyl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimidin Do[5,4-c]azepin-4-one; 6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)phenyl)-2-methyl- (1,1'-biphenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyridyl Mido[5,4-c]azepin-4-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one ； (R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylacetyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenyl Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H- Pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalene) (1-phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-hydroxy-2-(3-(pentafluoro-(λ)6-sulfanyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1- 6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3- (yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidinyl ... (Zin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (Nylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl 1-(1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropanediol) propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenyl) (phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylsilyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl (1-phenylcyclopropyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]a Zepin-4-one; 6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxy Acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; and 6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; or a pharmaceutically acceptable salt thereof.

8. A single enantiomer of a compound selected from the group consisting of: 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)silyl) chloropropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydrofuran Lahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile; 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; and 6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; or a pharmaceutically acceptable salt thereof.

9. A compound according to any one of claims 1 to 8 or a pharmaceutically acceptable salt thereof, and and a pharmaceutically acceptable carrier.

10. 10. The pharmaceutical composition of claim 9, further comprising another pharmacologically active agent.

11. Disease conditions or disorders mediated by TRPV4 receptor antagonist activity in non-human animals A method of treatment comprising administering to an animal in need of such treatment a therapeutically effective amount of a compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof. method.

12. 12. The method of claim 11, wherein the condition or disorder is one or more selected from the group consisting of inflammation, pain, and urinary diseases or disorders, and combinations thereof.

13. 12. The method of claim 11, wherein the condition or disorder is one or more selected from the group consisting of chronic pain; neuropathic pain including diabetic neuropathy; postoperative pain; osteoarthritis; rheumatoid arthritis pain; cancer pain; neuralgia; neuropathy; hyperalgesia, nerve injury; migraine; cluster headache and tension headache; ischemia; irritable bowel syndrome; inflammatory bowel disease; neurodegeneration; fibromyalgia; stroke; pruritus; psychiatric disorders including anxiety, anxiety about other stress-related disorders, and depression; inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD) and chronic obstructive airway disease (COAD); pulmonary hypertension; urinary diseases or disorders including detrusor overactivity or overactive bladder, urinary incontinence, neurogenic detrusor overactivity or detrusor hyperreflexia, idiopathic detrusor overactivity or detrusor instability, benign prostatic hyperplasia, and lower urinary tract symptoms; and combinations thereof.

14. 10. A compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof, for use in the treatment of a condition or disorder mediated by TRPV4 receptor antagonist activity.

15. For the manufacture of a medicament for treating a condition or disorder mediated by TRPV4 receptor antagonist activity. The compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof. , solvates, or compositions thereof.

16. 16. The use of claim 15, wherein the condition or disorder is one or more selected from the group consisting of inflammation, pain, and urinary diseases or disorders, and combinations thereof.

17. 16. The use of claim 15, wherein the condition or disorder is one or more selected from the group consisting of chronic pain; neuropathic pain including diabetic neuropathy; postoperative pain; osteoarthritis; rheumatoid arthritis pain; cancer pain; neuralgia; neuropathy; hyperalgesia, nerve injury; migraine; cluster headache and tension headache; ischemia; irritable bowel syndrome; inflammatory bowel disease; neurodegeneration; fibromyalgia; stroke; pruritus; psychiatric disorders including anxiety, anxiety about other stress-related disorders, and depression; inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD) and chronic obstructive airway disease (COAD); pulmonary hypertension; and urinary diseases or disorders including detrusor overactivity or overactive bladder, urinary incontinence, neurogenic detrusor overactivity or detrusor hyperreflexia, idiopathic detrusor overactivity or detrusor instability, benign prostatic hyperplasia, and lower urinary tract symptoms; and combinations thereof.

18. A compound according to any one of claims 1 to 8 or a pharmaceutically acceptable salt thereof; A method for preparing a pharmaceutical composition comprising mixing with a pharmaceutically acceptable carrier or excipient.

19. A compound represented by the following formula (Id): 【Chemistry 7】 During the ceremony, R 1 and R 2 is hydrogen and (C 1 -C 6 ) alkyl (only except that R 1 and R 2 are both hydrogen; or R 1 and R 2 together with the atoms to which they are attached form a 3- to 8-membered carbocyclic ring, wherein said 3- to 8-membered carbocyclic ring is free of halogen, hydroxyl, Roxyl, (C 1 -C 6 ) alkyl, and (C 1 -C 6 ) haloalkyl; R 3 are independently selected from the group consisting of hydrogen, fluorine, and methyl; q is 1, 2, 3, or 4; r is 1, 2, 3, or 4; s is 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.

20. A compound selected from the group consisting of: (R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl ... (R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)-2-methyl ... (ethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-2-(1-(2-bromopyridin-4-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-2-(1-(6-bromopyridin-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepi n-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo Propyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl) Cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridine-3-yl)- (cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-bromophenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-bromophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclo Propyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)silyl) (chloropropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophene-2- (yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one ； 6-(2-(3-bromophenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepine-4- on; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 6-(2-(3-bromophenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; 2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl] (phenyl)-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one and 2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; or a pharmaceutically acceptable salt thereof.

21. A compound selected from the group consisting of: 2-benzyl-6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(naphthalen-1-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-2-(1-benzylcyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; 2-(1-benzylcyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; (R)-6-(2-hydroxy-2-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)a cetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; and 6-(2-(4''-chloro-[1,1':4',1''-terphenyl]-3-yl)-2-hydroxyacetyl)-2-(1- (phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; or a pharmaceutically acceptable salt thereof.

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