Composition for lips

Abstract

To provide a composition for lips capable of improving dullness of lips.SOLUTION: There is provided a composition for lips comprising an oily base in which an effect of improving dullness of lips can be imparted to a composition for lips by blending ascorbyl tetrahexyldecanoate. Preferably, the composition for lips comprises at least any one selected from the group consisting of allantoins, pyridoxines and panthenols and comprises glycyrrhetic acids and / or tocopherols.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for lips. More specifically, the present invention relates to a composition for lips that has an effect of improving lip dullness. [Background technology]

[0002] The lips are formed by the lip-side mucosa in the oral cavity being inverted outward, and are usually referred to as the vermilion border anatomically. Thus, the lips are essentially different from normal skin on the face and body in that their basic structure is not skin but mucosa. For example, the lips have histological characteristics such as the absence of sebaceous glands present in normal skin, only scattered sebaceous glands being present and substantially no fat present on the stratum corneum, an extremely thin stratum corneum compared to normal skin, and a marked lack of melanocytes. In addition, the lips also have the morphological characteristics of being exposed to the outside of the body and constantly exposed to the external environment, despite being a mucosal tissue.

[0003] Due to the overlap of these histological and morphological characteristics, the lips are inherently very sensitive and have the unique problem of being prone to problems. For this reason, external compositions applied to the lips (lip compositions) are characterized by containing a very large amount of an oily base such as petrolatum, which protects the stratum corneum of the lips by forming an oil film.

[0004] Here, in general topical compositions, it is known that the "affinity between the base and the skin" (ease of the base to blend with the skin) and the "affinity between the base and the drug" (ease of dissolving the drug in the base) have a large effect on the percutaneous absorption of the drug (distribution to the stratum corneum) (Non-Patent Document 1), and the formulation of the topical skin composition is designed taking into consideration the balance between these. For example, in the case of a water-soluble drug, it is known that the use of an oily base improves both the "percutaneous absorption due to the affinity between the base and the skin" and the "percutaneous absorption due to the affinity between the base and the drug", but the use of a water-soluble base reduces both the "percutaneous absorption due to the affinity between the base and the skin" and the "percutaneous absorption due to the affinity between the base and the drug". In addition, in the case of fat-soluble drugs, it is known that the use of an oily base improves "transdermal absorbability due to the affinity between the base and the skin" but decreases "transdermal absorbability due to the affinity between the base and the drug," and that the use of a water-soluble base decreases "transdermal absorbability due to the affinity between the base and the skin" but improves "transdermal absorbability due to the affinity between the base and the drug."

[0005] Therefore, in lip compositions that use a large amount of oily base, water-soluble drugs, which have improved "perdermal absorbability due to the affinity between the base and the skin" and "perdermal absorbability due to the affinity between the base and the drug," are more advantageous in terms of perdermal absorption than fat-soluble drugs, which have reduced "perdermal absorbability due to the affinity between the base and the drug."

[0006] On the other hand, L-ascorbic acid is a water-soluble drug known to have an excellent effect of suppressing melanin production and a reducing effect on the produced melanin, which is effective for beautifying the skin, and has been incorporated into external compositions. However, since L-ascorbic acid has an enediol group, it has a structure that is easy to donate hydrogen, and is unstable in preparations due to its susceptibility to oxidation. In order to improve such poor oil solubility and formulation stability problems, L-ascorbic acid ester derivatives in which the hydroxyl groups of L-ascorbic acid are esterified have been provided. However, as described in Patent Document 1, since the L-ascorbic acid ester derivatives have residual hydroxyl groups at the 2- and 3-positions, and therefore the effect of improving poor oil solubility and formulation stability problems is not sufficient, further, L-ascorbic acid tetra-branched fatty acid ester derivatives in which all hydroxyl groups of L-ascorbic acid are esterified are provided, thereby improving the solubility in oil. Patent Document 1 also describes that L-ascorbic acid tetra-branched fatty acid ester derivatives are easily absorbed percutaneously through the stratum corneum. Patent Document 1 discloses that the whitening effect is improved by using L-ascorbyl tetra-2-hexyldecanoate as an L-ascorbic acid tetra-branched fatty acid ester derivative in combination with arbutin, kojic acid, tranexamic acid, dipotassium glycyrrhizinate, magnesium L-ascorbyl phosphate, and 2-O-α-glucosyl-L-ascorbic acid. L-ascorbyl tetra-2-hexyldecanoate has a structure in which isopalmitic acid, a sebum fatty acid, is bound to L-ascorbic acid. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] JP 2003-306419 A [Non-patent literature]

[0008] [Non-Patent Document 1] Edited by Michiteru Otani, "Tidbits on Ointments vol.1", [online], Maruho Co., Ltd., [Retrieved November 30, 2018], Internet <URL: https: / / www.maruho.co.jp / medical / pharmacist / infostore / vol01 / 05.html> Summary of the Invention [Problem to be solved by the invention]

[0009] Lips are inherently very sensitive and have a unique problem of being prone to problems. One example of such a problem is dull lips. Lips have a significantly low number of melanocytes and are easily exposed to external factors such as ultraviolet rays, so they become dull by directly receiving damage from external factors. While the entire face is often cared for by applying lotions and creams, the lips are not given appropriate care, which exacerbates the problem of dull lips. However, no lip compositions capable of improving dullness have been investigated so far.

[0010] Therefore, an object of the present invention is to provide a composition for lips that can improve dullness of the lips. [Means for solving the problem]

[0011] The lip composition uses a large amount of an oily base, and the base composition is crucially different from that of a composition applied to normal skin. In addition, in view of the technical common knowledge regarding transdermal absorbability, even if the same drug component is used, the transdermal absorbability varies depending on the type of base. Naturally, the difference in transdermal absorbability affects the action and effect exhibited. Therefore, in view of the technical common knowledge regarding transdermal absorbability, even if a drug component can exert an action and effect when blended in a topical composition applied to normal skin, the same action and effect cannot be expected in the lip composition.

[0012] As described above, L-ascorbyl tetra 2-hexyldecanoate is used in external compositions as a useful skin-beautifying ingredient. However, no external compositions containing L-ascorbyl tetra 2-hexyldecanoate are known that are specifically intended for use on the lips, and only those that are intended for use on normal skin are known. Since L-ascorbyl tetra 2-hexyldecanoate is designed to have higher oil solubility, its percutaneous absorption should be lower when it is mixed with an oily base, and in light of common technical knowledge regarding percutaneous absorption, even if it is applied to a composition for the lips, the effects that have been touted in normal compositions for external use on the skin cannot be expected. In addition, Patent Document 1 also describes that L-ascorbic acid tetra-branched fatty acid ester derivatives are easily absorbed percutaneously through the stratum corneum, but the reason why the percutaneous absorption is easy is that the L-ascorbic acid tetra-branched fatty acid ester derivatives have isopalmitic acid, which is one of the sebum fatty acids, in the molecule, and therefore have an affinity with the sebum present on the skin to which they are applied. Since there is practically no sebum on the lips, the effect of affinity with sebum as in normal skin cannot be expected. In other words, even if it is known that L-ascorbic acid tetra-branched fatty acid ester derivatives facilitate percutaneous absorption, even if they are incorporated into a composition for lips, the effect of facilitating percutaneous absorption as can be expected in a normal composition for external use on the skin cannot be expected.

[0013] In this situation, the present inventors conducted intensive research and surprisingly found that dull lips can be significantly improved by blending L-ascorbyl tetra-2-hexyldecanoate, which is not expected to be effective in lip compositions in light of common technical knowledge, into a lip composition. The present invention was completed through further research based on this finding.

[0014] That is, the present invention provides the following aspects. Item 1. A composition for lips that contains (A) an oily base and (B) ascorbyl tetrahexyldecanoate and is used to improve dullness of the lips. Item 2. The lip composition according to Item 1, wherein the content of the component (A) is 50 to 99.5% by weight. Item 3. The lip composition according to Item 1 or 2, wherein the component (A) contains a solid oil. Item 4. The lip composition according to Item 3, wherein the content of the solid oil is 30 to 70% by weight. Item 5. The composition for lips according to any one of Items 1 to 4, further comprising at least one selected from the group consisting of allantoins, pyridoxines, and panthenols. Item 6. The lip composition according to any one of Items 1 to 5, further comprising glycyrrhetinic acids and / or tocopherols. Item 7. A method for imparting an effect of improving lip dullness to a lip composition, comprising blending ascorbyl tetrahexyldecanoate in the lip composition containing an oily base. Effect of the Invention

[0015] The lip composition of the present invention can improve dullness of the lips. [Brief description of the drawings]

[0016] [Figure 1] 1 shows the measurement results showing the effect of the lip composition of Test Example 1 in improving melanin unevenness (effect of improving dullness). [Diagram 2] 1 shows the measurement results showing the improving effect on the average melanin concentration (dullness improving effect) of the lip composition of Test Example 1. [Diagram 3] 1 shows the measurement results showing the effect of the lip composition of Test Example 1 in improving the roughness of the texture of the lip surface (effect of improving lip wrinkles). [Figure 4] 1 shows the measurement results showing the effect of the lip composition of Test Example 1 in improving the depth of lip wrinkles (lip wrinkle improving effect). [Diagram 5] 1 is a photograph of lips (enlarged photograph of the lower lip) showing the effect of improving dullness and lip wrinkles by the lip composition of Test Example 2. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] 1. Lip composition The lip composition of the present invention is characterized by containing (A) an oily base (hereinafter also referred to as component (A)) and (B) ascorbyl tetrahexyldecanoate (hereinafter also referred to as component (B)) and being used to improve dullness of the lips. The lip composition of the present invention will be described in detail below.

[0018] (A) Oil base The lip composition of the present invention contains an oily base as component (A). Because an oily base has a strong affinity with an oil-soluble drug, the oil-soluble drug is inherently poor in percutaneous penetration and efficacy, but the lip composition of the present invention, despite containing an oily base, can achieve a remarkable improvement effect on dull lips.

[0019] The oil base includes (A1) solid oil and (A2) liquid oil. The oil base preferably contains at least solid oil. When the oil base contains solid oil, the fluidity is lost or extremely poor, which is preferable in that it is easy to fix the oil film of the lip composition to the lips, which is a localized part. On the other hand, in an oil base that has no fluidity or has extremely poor fluidity, the dispersibility of the oil-soluble drug is inherently poor, so that the distribution of the oil-soluble drug to the skin and the expression of its efficacy are poor. However, in the lip composition of the present invention, even if the oil base contains solid oil, a remarkable improvement effect on the dullness of the lips can be obtained.

[0020] (A1) solid oil (hereinafter also referred to as component (A1)) is an oil that maintains a solid form at 25° C. The solid oil used in the present invention may be any oil that is usually used in cosmetics, topical medicines, etc., and examples of such solid oils and fats include solid oils and fats, waxes, synthetic waxes, solid hydrocarbons, higher alcohols, and higher fatty acids. Examples of the wax include solid fats and oils such as cacao butter, lanolin, ozokerite, hydrogenated jojoba oil, and hardened castor oil; waxes such as candelilla wax, rice bran wax, beeswax, white beeswax, cotton wax, carnauba wax, shellac wax, Japan wax, and jojoba wax; synthetic waxes such as myristyl myristate, cetyl myristate, stearyl stearate, cetyl stearate, cetyl palmitate, cholesteryl stearate, cholesteryl oleate, dextrin palmitate, and inulin stearate; solid hydrocarbons such as petrolatum, polyethylene wax, paraffin wax, ceresin wax, microcrystalline wax, and gelled hydrocarbons; higher alcohols such as cetyl alcohol, stearyl alcohol, behenyl alcohol, and batyl alcohol; higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, 12-hydroxystearic acid, and undecylenic acid; and silicone wax.

[0021] Among these solid oils, solid fats and oils, waxes, synthetic waxes, and solid hydrocarbons are preferred, as they provide a more favorable effect of improving lip dullness; waxes and solid hydrocarbons are more preferred; white beeswax, petrolatum, microcrystalline wax, and gelled hydrocarbons are even more preferred; and petrolatum and microcrystalline wax are particularly preferred.

[0022] These solid oils may be used alone or in combination of two or more.

[0023] (A2) liquid oil (hereinafter also referred to as component (A2)) is an oil that maintains a liquid form at 25°C. The liquid oil used in the present invention may be any oil that is commonly used in cosmetics, topical medicines, etc., and examples thereof include vegetable oils such as avocado oil, camellia oil, macadamia nut oil, olive oil, jojoba oil, etc.; fatty acids such as oleic acid, isostearic acid, etc.; ester oils such as cetyl ethylhexanoate, ethylhexyl palmitate, octyldodecyl myristate, neopentyl glycol diethylhexanoate, glyceryl tri-2-ethylhexanoate, octyldodecyl oleate, isopropyl myristate, glyceryl triisostearate, and glyceryl di-methylmethoxycinnamate-monoethylhexanoate; silicone oils such as dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane, etc.; and liquid hydrocarbon oils such as liquid paraffin, squalene, squalane, etc.

[0024] Among these liquid oils, preferred are liquid hydrocarbon oils, and more preferred are liquid paraffin.

[0025] These liquid oils may be used alone or in combination of two or more.

[0026] The content of component (A) in the lip composition of the present invention is not particularly limited, as long as it occupies a relatively large proportion in the lip composition, but is preferably 50 to 99.5% by weight, more preferably 60 to 99.5% by weight, even more preferably 70 to 99.5% by weight, and even more preferably 75 to 99.5% by weight. In this way, when the topical composition contains most of an oily base, the transdermal permeability and efficacy of the oil-soluble drug are inherently worsened. However, in the lip composition of the present invention, even if the composition contains most of an oily base, a significant improvement effect on lip dullness can be obtained.

[0027] In addition, when the lip composition of the present invention contains the component (A1), the content of the component (A1) in the lip composition is not particularly limited, and from the viewpoint of better fixing the oil film of the lip composition to the lips and the viewpoint of the feeling of use, for example, 30 to 70% by weight, preferably 30 to 65% by weight, more preferably 30 to 60% by weight, even more preferably 40 to 60% by weight, and even more preferably 50 to 60% by weight. Lip compositions containing such a large amount of solid oil have no or very poor fluidity, so that the dispersibility of oil-soluble drugs is inherently poor, and the distribution of oil-soluble drugs to the skin and the expression of efficacy are further deteriorated. However, the lip composition of the present invention can obtain a remarkable improvement effect on dullness of the lips even if it contains a large amount of solid oil.

[0028] When the lip composition of the present invention contains the component (A2), its content is not particularly limited, but may be, for example, 15 to 60% by weight, preferably 20 to 55% by weight, and more preferably 20 to 50% by weight.

[0029] Furthermore, when the lip composition of the present invention contains both the component (A1) and the component (A2), the ratio of the component (A1) to the component (A2) is determined by the content of each of the above-mentioned components. The content of the component (A1) per 1 part by weight of the component (A2) is, for example, 0.5 to 3.5 parts by weight, preferably 0.5 to 3 parts by weight, and more preferably 1 to 3 parts by weight.

[0030] (B) Ascorbyl tetrahexyldecanoate The lip composition of the present invention contains ascorbyl tetrahexyldecanoate as component (B). Ascorbyl tetrahexyldecanoate is an L-ascorbic acid derivative in which all hydroxyl groups of L-ascorbic acid are esterified with isopalmitic acid (2-hexyldecanoic acid), and refers to L-ascorbyl tetra-2-hexyldecanoate (ascorbyl tetraisopalmitate).

[0031] Ascorbyl tetrahexyldecanoate has a very strong affinity with oily bases, so that external compositions containing oily bases inherently have poor percutaneous penetration and efficacy, but the lip composition of the present invention can achieve a significant improvement effect on lip dullness. In addition, ascorbyl tetrahexyldecanoate has isopalmitic acid, which is one of the sebum fatty acids, in its molecule, and inherently improves efficacy by affinity with sebum present on the skin to which it is applied, but since there is substantially no sebum on the lips to which the lip composition of the present invention is applied, it cannot be expected to have affinity with sebum like normal skin. However, the lip composition of the present invention can achieve a significant improvement effect on lip dullness.

[0032] The content of component (B) in the lip composition of the present invention is not particularly limited and can be set appropriately depending on the effect of improving lip dullness to be achieved, but can be, for example, from 0.5 to 5 parts by weight, preferably from 0.7 to 4 parts by weight, and more preferably from 1 to 3 parts by weight.

[0033] The ratio of the (A) component to the (B) component is determined by the content of each of the above components, and the content of the (B) component per 100 parts by weight of the (A) component may be, for example, 1 to 4.5 parts by weight. Since the lip composition of the present invention can provide a significant improvement effect on lip dullness, even if the content of the (B) component per 100 parts by weight of the (A) component is, for example, 1 to 3 parts by weight, 1 to 2.5 parts by weight, 1 to 2 parts by weight, or 1 to 1.5 parts by weight, the composition can effectively provide a significant improvement effect on lip dullness.

[0034] When the (A) component contains the (A1) component, the ratio of the (A1) component to the (B) component is determined by the content of each of the above components, and the content of the (B) component per 100 parts by weight of the (A1) component is, for example, 1.5 to 7.5 parts by weight, preferably 2 to 7.5 parts by weight. Since the lip composition of the present invention can obtain a remarkable improvement effect on lip dullness, even if the content of the (B) component per 100 parts by weight of the (A1) component is, for example, 1.5 to 6 parts by weight, 1.5 to 5 parts by weight, 1.5 to 4 parts by weight, 1.5 to 3 parts by weight, or 1.5 to 2.5 parts by weight, the remarkable improvement effect on lip dullness can be effectively obtained.

[0035] (C) Allantoins, pyridoxines, and / or panthenols The lip composition of the present invention may further contain at least one selected from the group consisting of allantoins, pyridoxines, and panthenols as component (C). These components are water-soluble drugs and have good percutaneous absorption when used with an oily base. In the lip composition of the present invention, in combination with ascorbyl tetrahexyldecanoate, it is possible to improve the effect of improving dullness of the lips.

[0036] In the composition for lips of the present invention, one or more of allantoins, pyridoxines, and panthenols may be used alone or in combination. From the viewpoint of obtaining a better effect of improving dullness of the lips, it is preferable to contain all of the above allantoins, pyridoxines, and panthenols.

[0037] Allantoins are allantoin and its derivatives, and specifically include allantoin, allantoin chlorhydroxyaluminum, allantoin hydroxyaluminum, etc. Among these allantoins, allantoin is preferred. These allantoins may be used alone or in combination of two or more.

[0038] When the lip composition of the present invention contains allantoins, the content of the allantoins in the lip composition is, for example, 0.01 to 2% by weight, and preferably 0.3 to 1% by weight.

[0039] Pyridoxines are vitamin B6, its derivatives, and their salts, specifically pyridoxine, pyridoxal, pyridoxamine, and inorganic acid salts thereof (e.g., hydrochloride, sulfate, nitrate, hydrobromide, phosphate, etc.). Among these pyridoxines, pyridoxine hydrochloride is preferred. These pyridoxines may be used alone or in combination of two or more.

[0040] When the lip composition of the present invention contains a pyridoxine, the content of the pyridoxine in the lip composition is, for example, 0.01 to 2% by weight, and preferably 0.05 to 0.5% by weight.

[0041] Panthenols are panthenol, its derivatives, and their salts, and specifically include panthenol, pantothenyl ethyl ether, alkaline earth metal salts of pantothenic acid (e.g., calcium salt, etc.), alkali metal salts of pantothenic acid (e.g., sodium salt, etc.), acetylpantothenyl ethyl ether, etc. Among these panthenols, panthenol is preferable. These panthenols may be used alone or in combination of two or more.

[0042] When the lip composition of the present invention contains a panthenol, the content of the panthenol in the lip composition is, for example, 0.01 to 5% by weight, and preferably 0.1 to 2% by weight.

[0043] (D) Glycyrrhetinic acids and / or tocopherols The lip composition of the present invention can further contain glycyrrhetinic acids and / or tocopherols as component (D). These components are oil-soluble drugs and inherently have poor percutaneous absorption when used with an oily base material. However, in the lip composition of the present invention, in combination with ascorbyl tetrahexyldecanoate, it is possible to improve the effect of improving dullness of the lips.

[0044] The lip composition of the present invention may contain one or more of glycyrrhetinic acids and tocopherols. In order to obtain a better effect of improving dullness of the lips, it is preferable to contain both glycyrrhetinic acids and tocopherols.

[0045] The glycyrrhetinic acid is glycyrrhetinic acid, its derivatives, and their salts, and specifically includes glycyrrhetinic acid, glycerin glycyrrhetinate, stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, etc. Among these glycyrrhetinic acids, glycyrrhetinic acid is preferable. These glycyrrhetinic acids may be used alone or in combination of two or more.

[0046] When the lip composition of the present invention contains glycyrrhetinic acids, the content of the glycyrrhetinic acids in the lip composition is, for example, 0.01 to 5% by weight, and preferably 0.1 to 2% by weight.

[0047] The tocopherols are tocopherol and its derivatives, and specifically include α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, tocopherol (linoleate / oleate), etc. Among these tocopherols, tocopherol acetate is preferable. These tocopherols may be used alone or in combination of two or more.

[0048] From the viewpoint of obtaining an even better effect of improving dullness of the lips, the lip composition of the present invention preferably contains at least one selected from the group consisting of allantoins, pyridoxines, panthenols, glycyrrhetinic acids, and tocopherols, more preferably contains all of allantoins, pyridoxines, panthenols, glycyrrhetinic acids, and tocopherols, and even more preferably contains all of allantoin, pyridoxine hydrochloride, panthenol, glycyrrhetinic acid, and tocopherol acetate.

[0049] Other Ingredients The composition for lips of the present invention may contain medicinal ingredients other than the above-mentioned components (B), (C), and (D) as necessary, so long as the effects of the present invention are not impaired. Examples of such medicinal ingredients include anti-inflammatory agents, anti-aging agents, astringents, antioxidants, moisturizing agents, blood circulation promoters, antibacterial agents, bactericides, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation mitigators, analgesics, cell activators, enzyme components, herbal medicine components, etc.

[0050] Furthermore, the lip composition of the present invention may contain additives such as surfactants, thickeners, aqueous bases, buffers, chelating agents, antioxidants, stabilizers, preservatives, fragrances, refreshing agents, colorants, dispersants, fluidizing agents, moisturizing agents, humectants, etc., as necessary, to the extent that the effects of the present invention are not impaired. Among these components, surfactants, thickeners, and aqueous bases are preferred.

[0051] The surfactant may be a nonionic surfactant, an anionic surfactant, a cationic surfactant, or an amphoteric surfactant, and preferably a nonionic surfactant. The nonionic surfactant may be a lipophilic nonionic surfactant or a hydrophilic nonionic surfactant. The nonionic surfactant may be either a lipophilic nonionic surfactant or a hydrophilic nonionic surfactant, or both of them may be used.

[0052] Examples of lipophilic nonionic surfactants include sorbitan fatty acid esters such as sorbitan monostearate, sorbitan monoisostearate, and sorbitan sesquioleate; glycerin polyglycerin fatty acid such as glycerin monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; and glycerin alkyl ethers. Among these lipophilic nonionic surfactants, preferred are sorbitan fatty acid esters and glycerin polyglycerin fatty acid, and more preferred are sorbitan monostearate and glycerin monostearate. These lipophilic nonionic surfactants may be used alone or in combination of two or more.

[0053] When the lip composition of the present invention contains a lipophilic nonionic surfactant, the content of the lipophilic nonionic surfactant is, for example, 0.5 to 10 parts by weight, and preferably 0.8 to 8 parts by weight.

[0054] Examples of hydrophilic nonionic surfactants include polyoxyethylene (hereinafter abbreviated as POE), POE sorbitan fatty acid esters such as POE sorbitan monostearate; POE sorbit fatty acid esters such as POE sorbit monooleate; POE glycerin fatty acid esters such as POE glycerin monoisostearate; POE stearyl ether, POE cholestanol ether, and other POE alkyl phenyl ethers; POE nonylphenyl ether, and other POE alkyl phenyl ethers; Pluronic (registered trademark), and other Pluronic-type surfactants; POE·polyoxypropanesulfonyl ethers; Examples of the hydrophilic nonionic surfactants include POE·POP alkyl ethers such as propylene (hereinafter abbreviated as POP) cetyl ether, tetraPOE·tetraPOP ethylenediamine condensates such as Tetronic, POE castor oil, POE castor oil hydrogenated castor oil derivatives such as POE hydrogenated castor oil, POE beeswax·lanolin derivatives, alkanolamides, POE propylene glycol fatty acid esters, POE alkylamines, POE fatty acid amides, sucrose fatty acid esters, POE nonylphenyl formaldehyde condensates, alkylethoxydimethylamine oxides, trioleyl phosphates, etc. Among these hydrophilic nonionic surfactants, POE sorbitan fatty acid esters are preferred, and POE sorbitan monostearate is more preferred. These hydrophilic nonionic surfactants may be used alone or in combination of two or more.

[0055] When the lip composition of the present invention contains a hydrophilic nonionic surfactant, the content of the hydrophilic nonionic surfactant is, for example, 0.5 to 7 parts by weight, and preferably 0.8 to 2.5 parts by weight.

[0056] Examples of the thickener include oil-soluble thickeners and water-soluble thickeners, and preferably oil-soluble thickeners. Examples of the oil-soluble thickener include dextrin fatty acid esters such as dextrin palmitate, dextrin oleate, and dextrin stearate; sucrose fatty acid esters in which three or less of eight hydroxyl groups are esterified with higher fatty acids, and the higher fatty acids are stearic acid and palmitic acid; and benzylidene derivatives of sorbitol such as monobenzylidene sorbitol and dibenzylidene sorbitol. Among these oil-soluble thickeners, dextrin fatty acid esters are preferred, and dextrin palmitate is more preferred. These oil-soluble thickeners may be used alone or in combination of two or more.

[0057] When the lip composition of the present invention contains a thickener, the content of the thickener is, for example, 0.2 to 5 parts by weight, and preferably 0.5 to 1.5 parts by weight.

[0058] Examples of the aqueous base include water, polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, and dipropylene glycol, and preferred are water and glycerin.

[0059] When the lip composition of the present invention contains an aqueous base, the content of the aqueous base can be, for example, more than 0 parts by weight and not more than 20 parts by weight, preferably more than 0 parts by weight and not more than 18 parts by weight. When the lip composition of the present invention contains water among the aqueous bases, the content of water can be, for example, more than 0 parts by weight and not more than 7 parts by weight, preferably more than 0 parts by weight and not more than 5 parts by weight.

[0060] Formulation The formulation form of the lip composition of the present invention is not particularly limited, and examples thereof include gel, paste, and solid forms. Specific forms of the lip composition of the present invention include oily preparations that do not contain water, and water-in-oil emulsions that contain a small amount of water. More specific forms of the lip composition of the present invention include lip balm, lip gloss, and lipstick. The lip composition of the present invention may be any of general skin cosmetics, medicinal cosmetics, quasi-drugs, and medicines, but is preferably a medicine.

[0061] Method for producing lip composition The lip composition of the present invention is prepared by mixing desired amounts of the above-mentioned components (A) and (B), the components (C) and (D) which are blended as necessary, the other medicinal components described above, additives, etc.

[0062] Method of using the lip composition The lip composition of the present invention can be applied to the lips for the purpose of improving lip dullness. Therefore, the lip composition of the present invention can be used by people who are aware of lip dullness. The lip composition of the present invention can also be used as part of daily care to prevent lip dullness. In the method of using the lip composition of the present invention, it can be applied to the lips, for example, 1 to 3 times a day, preferably 1 to 2 times a day. In order to achieve a desirable effect, the lip composition of the present invention is preferably applied continuously, and the application period can be, for example, 3 weeks or more, preferably 4 weeks or more, and more preferably 8 weeks or more.

[0063] 2. Method for improving dull lips As described above, in a lip composition containing an oily base, ascorbyl tetrahexyldecanoate shows an effect of improving lip dullness. Therefore, the present invention further provides a method for imparting an action of improving lip dullness to a lip composition, which is characterized by blending ascorbyl tetrahexyldecanoate in a lip composition containing an oily base.

[0064] In the present invention, dull lips refer to a condition in which lips, which have a significantly low number of melanocytes, are directly damaged by external factors such as ultraviolet rays, resulting in a darker color on the lip surface. Specifically, this is visually recognized as uneven color (uneven color) due to spots, darkening, etc. In addition, in the present invention, improving dull lips refers to lightening the darker parts of the lips in a lip composition containing an oily base, lowering the average color density, and making the uneven color closer to uniform, compared to a composition not containing ascorbyl tetrahexyldecanoate.

[0065] In addition, in a lip composition containing an oily base, ascorbyl tetrahexyldecanoate not only shows an effect of improving dullness of the lips, but also shows an effect of improving wrinkles on the lips when used by a person who is aware of lip wrinkles. "Improving lip wrinkles" means that in a lip composition containing an oily base, the depth of lip wrinkles is made shallower and / or lip wrinkles are made less noticeable than when ascorbyl tetrahexyldecanoate is not contained, and particularly refers to the effect on vertical wrinkles on the lips.

[0066] Furthermore, in lip compositions containing an oily base, ascorbyl tetrahexyldecanoate not only shows an effect of improving dull lips, but also shows an effect of improving poor lip color when used by people who are aware of poor lip color. Poor lip color refers to a state in which the lips as a whole have little color (redness). The poorer the lip color, the closer the border between the lips (part with the mucous membrane as the basic structure) and the skin is to the color of the skin, so the area of ​​the reddish part in the front view of the lips is small, and as a result, the thickness of the lips in the vertical direction tends to be thin. In addition, there are cases in which the lips are actually thin and have little volume. Improving such poor lip color refers to increasing the color (redness) of the whole lips in a lip composition containing an oily base compared to when it does not contain ascorbyl tetrahexyldecanoate. When the poor color of the lips is improved more significantly, the redness increases up to the boundary between the lips (the part whose underlying structure is the mucous membrane) and the skin, and the area of ​​the reddish part when viewed from the front of the lips increases, and as a result, the effect of the lips increasing in the vertical direction (feeling of fuller lips) may be visible. This feeling of fuller lips is particularly easily visible in the lower lip. Furthermore, the effect of fuller lips may actually be obtained, with the volume of the lips increasing.

[0067] By providing a lip composition with an effect of improving not only lip wrinkles but also poor lip color and / or lip dullness, these effects can be combined to bring about an even healthier lip condition.

[0068] In the method for imparting an effect of improving lip dullness, the types and amounts of components used, the form of the lip composition, the method of use, etc. are as shown in the section "1. Lip composition" above. EXAMPLES

[0069] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these.

[0070] Test Example 1 [Preparation of lip composition] A lip composition was prepared according to the composition shown in Table 1. Specifically, component (A) and a surfactant were mixed and heated and dissolved in a water bath at 85°C to obtain a premixture. Component (B) was added to the premixture while thoroughly stirring, and then cooled to 35°C while stirring to obtain a lip composition.

[0071] Each of the obtained lip compositions was applied once a day for 8 weeks to the lips of 10 women who were aware of dull lips (uneven lip color). These 10 subjects were also aware of poor lip color (poor lip color overall) and wrinkles.

[0072] [Evaluation of improvement effects] (Sensory evaluation) After applying the lip composition for 8 weeks, the number of people who felt that the unevenness of the lip color was eliminated and the color improved to a uniform appearance was classified according to the following criteria, and the effect of improving dull lips was evaluated. In addition, the number of people who felt that the color of the lips improved to a healthy pink color was similarly classified according to the following criteria, and the effect of improving poor complexion was also evaluated. In addition, the number of people who felt that the lip wrinkles became shallower and the lip surface improved to a smooth appearance was also classified according to the following criteria, and the effect of improving lip wrinkles was also evaluated. The results are shown in Table 1. ○:7 or more people △:4~6 people ×: 3 people or less

[0073] (Measurement evaluation) Before applying the lip composition of Example 1 (initial stage) and after applying the lip composition for 8 weeks, the skin was analyzed using the ANTERA3D skin analyzer. TMThe melanin heterogeneity and average melanin concentration were measured using the ANTERA3D skin analyzer. Specifically, measurements were taken three times for each subject, initially and after 8 weeks, and the worst (highest) measurement of the three was taken as the definitive measurement (initial) and definitive measurement (after 8 weeks) for that subject. Furthermore, the definitive measurement (initial) and definitive measurement (after 8 weeks) for each of the 10 subjects were averaged. The results are shown in Figure 1 (melanin heterogeneity) and Figure 2 (average melanin concentration), respectively. The smaller the average definitive measurement value after 8 weeks compared to the average initial definitive measurement value, the greater the improvement effect on dullness of the lips. Furthermore, using the skin analyzer ANTERA3D TM In addition to the above measurements, lip surface roughness (roughness of the texture of the lip surface) and lip wrinkles (depth of lip wrinkles) were also measured and averaged using the same method. The smaller the average confirmed measurement value after 8 weeks compared to the initial confirmed measurement value, the greater the improvement effect on lip wrinkles. The results are shown in Figure 3 (lip surface roughness) and Figure 4 (lip wrinkles), respectively.

[0074] [Table 1]

[0075] As is clear from Table 1, the lip compositions (Examples 1 to 7) containing ascorbyl tetrahexyldecanoate in an oily base exhibited a significant improvement effect on dullness of the lips compared to the lip compositions (Comparative Examples 1 to 4) not containing ascorbyl tetrahexyldecanoate. Such a significant improvement effect was observed not only on lip wrinkles, but also on poor color and wrinkles of the lips. Also, as is clear from Figures 1 and 2, it was found that the uniformity of melanin and the average concentration of melanin were significantly improved objectively, and dullness was significantly improved. Furthermore, in addition to the improvement effect on dullness of the lips, as is clear from Figures 3 and 4, it was found that the roughness of the lip surface and the depth of lip wrinkles were significantly improved objectively, and lip wrinkles were also significantly improved.

[0076] Test Example 2 [Preparation of lip composition] A lip composition was prepared according to the composition shown in Table 2. Specifically, components (A), (C), (D) and a surfactant were mixed and dissolved by heating in a water bath at 85°C to obtain a premixture. Component (B) was added to the premixture while thoroughly stirring, and the mixture was cooled to 35°C while stirring to obtain a lip composition.

[0077] The obtained lip composition was applied to the lips of women who were aware of dull lips once a day for 8 weeks. In addition to dull lips, these women were also aware of poor lip color and / or lip wrinkles. Among these women, the lip composition of Example 13 was applied to women 2 and 3. Woman 2 was aware of not only dull lips (particularly spot-like spots present under the lower lip) but also lip wrinkles. Woman 3 was strongly aware of dull lips (particularly dark spots present over a relatively wide area above the lower lip), and objectively, the dullness was a relatively large problem, and she was also aware of poor lip color. Enlarged photographs of a part of the lower lip of Woman 2 are shown in Figure 5 (Woman 2; initial, after 4 weeks of application, and after 8 weeks of application).

[0078] [Table 2]

[0079] As a result, when the lip compositions of Examples 8 to 13 were applied, the improvement effect against dull lips was more excellent. Also, not only for dull lips, but also for people who were aware of poor lip color, an even better improvement effect was observed, and for people who were aware of lip wrinkles, an even better improvement effect was observed.

[0080] Specifically, as shown in Figure 5, for the lip composition of Example 13, in the case of Woman 2, spot-like spots were observed at the area indicated by the white triangle mark in the photograph at the beginning, but after only 4 weeks, the spots were clearly fading, and after 8 weeks, the spots had almost disappeared, resulting in a more significant improvement effect on dullness. Also, as shown in Figure 5, in the case of Woman 2, the deepest vertical wrinkles indicated by the black arrow in the photograph became significantly shallower even after only 4 weeks, and overall the unevenness of the lip surface became significantly smoother, resulting in a more significant improvement effect on lip wrinkles.

[0081] In the case of the female 3 to whom the lip composition of Example 13 was applied, the darkening of the lips, which had been strongly felt over a relatively wide area, became less noticeable after only 4 weeks, and was further significantly eliminated after 8 weeks. Furthermore, in the case of the female 3, the color of the lips was clearly improved after only 4 weeks, and was further significantly eliminated after 8 weeks. As a result, the area of ​​redness in the lips of the female 3 increased, and in particular, the maximum thickness of the lower lip in the vertical direction increased from 7 mm at the beginning to 9 mm after 8 weeks of application, giving a feeling of fuller lips.

[0082] Prescription Examples Lip compositions having the formulations shown in Tables 3 and 4 were prepared. Specifically, component (A), component (D), surfactant, and thickener were mixed and dissolved by heating in a water bath at 85°C, and then component (C) and an aqueous base, which had been separately dissolved by heating in a water bath at 85°C, were mixed to obtain a premixture. Component (B) was added to the premixture while thoroughly stirring, and the mixture was cooled to 35°C while stirring to obtain lip compositions of Formulation Examples 1 to 15. For the lip compositions of all of the Formulation Examples, the effect of further improving lip dullness, the effect of further improving lip wrinkles, and the effect of further improving poor lip color, as well as the effect of feeling fuller lips and / or fuller lips were obtained, as observed in Test Example 2.

[0083] [Table 3]

[0084]

Table 4

Claims

1. A lip composition used to improve lip discoloration caused by spots or darkening, comprising (A) 50 to 99.5% by weight of a solid hydrocarbon and a liquid hydrocarbon, (B) ascorbyl tetrahexyldecanoate, (C) an allantoin and / or a pyridoxine, and (D) a glycyrrhetinic acid.

2. 2. The lip composition according to claim 1, wherein the content of the solid oil is 30 to 70% by weight.

3. The lip composition according to claim 1 or 2, further comprising a panthenol.

4. The lip composition according to any one of claims 1 to 3, further comprising tocopherols.

5. A method for imparting to a lip composition an effect of improving discoloration caused by spots or darkening of the lips, characterized in that (A) the lip composition contains 50 to 99.5% by weight of solid hydrocarbons and liquid hydrocarbons, and (B) ascorbyl tetrahexyldecanoate, (C) allantoins and / or pyridoxines, and (D) glycyrrhetinic acids.

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