Leave-on disinfectant composition

Abstract

To provide a leave-on disinfectant composition that has bactericidal properties, can leave the bactericidal components on the surface of an object for a long time when applied to the object, and is easy to be absorbed in the skin surface when applied to the skin.SOLUTION: Provided is a leave-on disinfectant composition containing component (A): a polyol having bactericidal properties, and component (B): a compound other than component (A) (however, excluding water and lower alcohols), when the octanol / water partition coefficient of component (A) is logPA and the octanol / water partition coefficient of component (B) is logPB, the difference between logPB and logPA (logPB-logPA) being -2.20 or more and 3.00 or less, the total content of component (A) and component (B) in the composition being 3.0 mass% or more and 10 mass% or less, and the mass ratio of component (A) to component (B) [(A) / (B)] being 7.5 or less.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to leave-on disinfectant compositions. [Background technology]

[0002] According to recent surveys, it is now known that contact infection is the most common route of bacterial or viral infection in people's daily lives. Contact infection occurs mainly when hands come into contact with infected people, doorknobs, handles, tableware, toys, other daily necessities, interior items, etc.

[0003] There is a demand for methods to prevent such bacterial or viral infections caused by contact behavior in daily life. As a method for preventing contact infection of bacteria or viruses through hands, a method of applying an alcohol-based disinfectant to hands and fingers for sterilization and disinfection is known. However, alcohol such as ethanol used as a sterilizing or disinfecting component is highly volatile and difficult to remain on the skin surface for a long time, so the duration of the sterilizing performance is insufficient.

[0004] Therefore, leave-on type skin disinfectant or antibacterial composition containing a bactericidal component other than ethanol is also being considered. For example, Patent Document 1 discloses that a sustained-effect bactericidal antiseptic cream containing a cationic bactericidal disinfectant, a lower alcohol, an oily base, a higher aliphatic alcohol, a lipophilic and hydrophilic nonionic surfactant, a water-soluble polyhydric alcohol and purified water has a sustained disinfecting effect on the skin, fingers and traumatic wounds and an effect of preventing rough hands. Patent Document 2 discloses that an antibacterial composition containing 0.1 to 10% by weight of soluble azelaic acid and having a pH within a specific range can exert antibacterial activity sufficient for practical use. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2007-284412 A [Patent Document 2] JP 2016-188258 A Summary of the Invention [Problem to be solved by the invention]

[0006] In the compositions described in Patent Documents 1 and 2, a specific bactericide or antibacterial agent is used. However, according to the study by the present inventors, it has been found that the cationic bactericide used in Patent Document 1 is less effective at killing bacteria on the human skin surface than inorganic materials such as stainless steel and glass. As also described in Patent Document 2, the amount of the bactericide or antibacterial agent to be incorporated in the composition for skin may be substantially limited from the viewpoint of skin irritation, safety to the human body, etc. Therefore, in the conventional technology, the bactericidal properties and sustained effect of the bactericide or antibacterial agent on the skin are not sufficient, and further improvement is desired. In particular, in a leave-on type composition that is applied to the skin and used without being washed off, a technology that allows the bactericidal component to remain on the skin surface for a long time is also important in order to obtain a sustained bactericidal effect. However, Patent Documents 1 and 2 do not mention this technology. Furthermore, for leave-on compositions, compatibility with the skin surface when applied is also important, but this point is not discussed in Patent Documents 1 and 2.

[0007] The present invention relates to a leave-on disinfectant composition which has bactericidal properties, is capable of leaving a bactericidal component on the skin surface for a long period of time when applied to the skin, and is easily compatible with the skin surface. [Means for solving the problem]

[0008] The present inventors have found that a leave-on disinfectant composition containing a polyol having bactericidal properties and a compound that satisfies a specific relationship with the polyol in a specific ratio exerts the above-mentioned effects. That is, the present invention relates to the following. [1] A leave-on disinfectant composition comprising component (A): a polyol having bactericidal properties, and component (B): a compound other than component (A) (excluding water and lower alcohols), wherein component (B) has an octanol / water partition coefficient smaller than logP A The octanol / water partition coefficient of the component (B) is logP B In this case, logP B and logP A Difference from (logP B -logP A ) is -2.20 or more and 3.00 or less, the total content of the component (A) and the component (B) in the composition is 3.0 mass% or more and 10 mass% or less, and the mass ratio of the component (A) to the component (B) [(A) / (B)] is 7.5 or less. [2] A method for disinfecting skin, comprising the step of applying the leave-on disinfectant composition described in [1] above to the skin. [3] A method for sustaining the bactericidal effect of a polyol (A) having bactericidal properties, the method comprising the steps of using the component (A) and a compound (B) other than the component (A) (excluding water and lower alcohols), the component (B) being such that the octanol / water partition coefficient of the component (A) is less than logP A The octanol / water partition coefficient of the component (B) is logP B In this case, logP B and logP A Difference from (logP B -logP A ) is -2.20 or more and 3.00 or less, and the mass ratio of the component (A) to the component (B) [(A) / (B)] is 7.5 or less. Effect of the Invention

[0009] According to the present invention, a leave-on disinfectant composition can be provided which has bactericidal properties, is capable of leaving a bactericidal component on the surface of an object for a long period of time when applied to the object, and is easily absorbed into the skin surface when applied to the skin. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] [Leave-on disinfectant composition] The leave-on disinfectant composition of the present invention (hereinafter, also simply referred to as "the composition (of the present invention)") is a leave-on disinfectant composition containing component (A): a polyol having bactericidal properties, and component (B): a compound other than component (A) (excluding water and lower alcohols), wherein component (B) has an octanol / water partition coefficient smaller than logP A The octanol / water partition coefficient of the component (B) is logP B In this case, logP B and logP A Difference from (logP B -logP A ) is -2.20 or more and 3.00 or less, the total content of the component (A) and the component (B) in the composition is 3.0 mass% or more and 10 mass% or less, and the mass ratio of the component (A) to the component (B) [(A) / (B)] is 7.5 or less. Because the composition of the present invention has the above-mentioned configuration, it has bactericidal properties, and when applied to an object, the bactericidal component can remain on the surface of the object for a long period of time, and when applied to the skin, it becomes a leave-on disinfectant composition that is easily absorbed into the skin surface.

[0011] The reason why the composition of the present invention exhibits the above-mentioned effects is not clear, but is thought to be as follows. The polyol, which is component (A), has a hydrophilic hydroxyl group and a hydrophobic portion containing carbon atoms. The hydrophilic portion has a high affinity with water molecules and forms an interaction. On the other hand, the hydrophobic portion distorts or destroys the three-dimensional hydrogen bond network of water. This has the same effect as ethanol, etc. The distortion or destruction of the three-dimensional hydrogen bond network of water changes the water environment around the bacteria. This change is thought to have the effect of denaturing, for example, the hydrophilic membrane protein of bacteria.

[0012] From the viewpoint of compatibility with the skin surface, it is preferable that component (A) is a low molecular weight polyol as described below. Although component (A), which is a low molecular weight polyol, is less volatile than ethanol, when used as a bactericidal component for a leave-on disinfectant composition, it may volatilize over time after application to the skin surface, and the durability of the bactericidal performance may decrease. As a result of the inventors' investigation, it was found that the volatilization of component (A) can be suppressed by using a compound (component (B)) whose octanol / water partition coefficient difference with component (A) is within a specific range in a predetermined ratio. This action makes it possible to allow component (A), which is a bactericidal component, to remain on the surface of the object for a long time when the composition is applied to the object, and it is considered that the durability of the bactericidal performance of component (A) is improved. In addition, it is believed that when the total content of components (A) and (B) in the composition is 3.0% by mass or more, sufficient bactericidal performance can be ensured, and when it is 10% by mass or less, the composition can be quickly absorbed into the skin surface.

[0013] From the viewpoint of the high usefulness of the present invention, the subject to which the composition of the present invention is applied is preferably the skin, more preferably the skin excluding the scalp. That is, the composition of the present invention is preferably a leave-on disinfectant composition for the skin. In this specification, the term "leave-on disinfectant composition for the skin" refers to a disinfectant composition for the skin that is used after application to the skin without being removed by washing with water or the like. From the viewpoint of the high usefulness of the present invention, the composition of the present invention is more preferably a leave-on disinfectant composition for hands.

[0014] The bacteria against which the composition of the present invention exerts its bactericidal properties are not particularly limited, so long as they are inactivated or killed by contact with the composition. For example, the microorganisms listed in the Ministry of Health, Labor and Welfare's guidelines for infectious disease control in daycare centers can be applied. Specific examples of bacteria include gram-positive bacteria such as Bacillus anthracis, Mycobacterium tuberculosis, Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis, and gram-negative bacteria such as Francisella tularensis, Yersinia pestis, Brucella, Bacillus mallei, Vibrio cholerae, Salmonella, Shigella, Escherichia coli, and Bordetella pertussis.

[0015] The composition of the present invention can also be used as a disinfectant composition against not only bacteria but also viruses, such as enveloped viruses arenavirus, Ebola virus, smallpox virus, Nairo virus, Marburg virus, coronavirus, monkeypox virus, betacoronavirus, influenza virus, RS virus, herpes virus, mumps virus, varicella-zoster virus, rubella virus, and measles virus, and non-enveloped viruses such as enterovirus, adenovirus, coxsackievirus, norovirus, and rotavirus. In this example, the bactericidal activity is evaluated using enterococci as an example, but the bacteria or viruses targeted by the method of the present invention are not limited to this.

[0016] <Component (A): Polyol with bactericidal properties> The polyol having bactericidal properties used as component (A) refers to a compound having two or more hydroxyl groups in one molecule and having bactericidal properties. The term "having bactericidal properties" used herein refers to a composition containing 0.1 to 5% by mass of component (A) with the remainder being ethanol and water, and a bactericidal evaluation was performed using the Enterococcus hirae Farrow and Collins 1985 NBRC 3181 strain described in the Examples. The composition was tested for a bactericidal activity of 0.1 to 5% by mass of component (A) at a concentration of 0.01 mg / cm. 2 and the logarithmic reduction in the number of bacteria when the same amount of a composition obtained by removing component (A) from the composition is used, the difference (ab) between the logarithmic reduction in the number of bacteria when the composition is used in an amount such that (a) is 0.50 or more. The above bactericidal performance can be specifically evaluated by the method described in the Examples.

[0017] LogP is the octanol / water partition coefficient of component (A) AFrom the viewpoint of improving the bactericidal performance, logP is preferably −3.00 or more, more preferably −2.50 or more, even more preferably −2.00 or more, still more preferably −1.50 or more, still more preferably −1.20 or more, still more preferably −1.00 or more, and still more preferably −0.50 or more. A It is considered that the larger the value, the higher the hydrophobicity of component (A), and the easier it is to obtain the effect of distorting or destroying the three-dimensional hydrogen bond network of water. On the other hand, from the viewpoint of preventing percutaneous absorption of component (A) when the composition is applied to the skin and improving the bactericidal performance and its duration, it is also desirable to have a logP A is preferably 3.00 or less, more preferably 2.00 or less, and even more preferably 1.00 or less. Where: P A : The concentration ratio of component (A) in two solvent phases, 1-octanol and water, when component (A) is added to the two solvent phases and equilibrium is reached. logP A =log 10 (Concentration of component (A) in 1-octanol phase / Concentration of component (A) in aqueous phase) It is. LogP of component (A) A can be determined using ChemDraw Professional.

[0018] The boiling point of component (A) is not particularly limited, but from the viewpoint of improving the bactericidal performance and from the viewpoint of allowing component (A) to remain on the surface of the object for a long time when applied to the object and improving the durability of the bactericidal performance of the composition, it is preferably 100° C. or higher, more preferably 120° C. or higher, even more preferably 150° C. or higher, even more preferably 180° C. or higher, and even more preferably 200° C. or higher. In addition, from the viewpoint of improving compatibility with the skin surface, it is preferably 300° C. or lower, more preferably 270° C. or lower, and even more preferably 250° C. or lower. The above boiling points are those at normal pressure (1 atm) and 25°C.

[0019] From the viewpoint of improving the bactericidal performance of the composition and improving compatibility with the skin surface, the component (A) is preferably a low molecular weight compound. Specifically, the molecular weight of the component (A) is preferably 1,000 or less, more preferably 800 or less, even more preferably 500 or less, even more preferably 300 or less, even more preferably 250 or less, and even more preferably 200 or less. In addition, from the viewpoint of allowing the composition to remain on the skin surface for a long time when applied to the skin and improving the durability of the bactericidal performance of the composition, the molecular weight is preferably 50 or more, more preferably 80 or more, and even more preferably 100 or more.

[0020] The number of carbon atoms in component (A) is preferably 3 or more, more preferably 4 or more, and even more preferably 5 or more, from the viewpoint of improving the bactericidal performance and of allowing component (A) to remain on the surface of an object for a long period of time when applied to the object and improving the durability of the bactericidal performance of the composition, and from the viewpoint of improving the bactericidal performance by distorting or destroying the three-dimensional hydrogen bond network of water, the number of carbon atoms is preferably 24 or less, more preferably 20 or less, even more preferably 16 or less, still more preferably 12 or less, still more preferably 11 or less, and even more preferably 8 or less. Furthermore, from the viewpoint of improving the bactericidal performance and allowing component (A) to remain on the surface of an object for a long period of time when applied to the object, thereby improving the durability of the bactericidal performance of the composition, the number of hydroxy groups in component (A) is preferably 2 or more and 5 or less, more preferably 2 or more and 4 or less, even more preferably 2 or more and 3 or less, and still more preferably 2.

[0021] Examples of the component (A) include linear polyols and polyols having a cyclic structure that have bactericidal properties. The term "linear" in linear polyols includes both straight chains and branched chains. From the viewpoint of exhibiting bactericidal performance by distorting or destroying the three-dimensional hydrogen bond network of water, component (A) is preferably a chain polyol, more preferably a chain polyol having from 4 to 12 carbon atoms, and even more preferably a chain diol or triol having from 4 to 12 carbon atoms. In the chain polyol, the bonding position of the hydroxy group is not particularly limited.

[0022] The component (A) may be one or more members selected from the group consisting of dipropylene glycol and 1,2-hexanediol. Among the above, from the viewpoint of improving the bactericidal performance and improving compatibility with the skin surface, the component (A) is preferably dipropylene glycol.

[0023] <Component (B): Compound other than component (A)> Component (B) is a compound other than component (A) (excluding water and lower alcohols) that has an octanol / water partition coefficient of component (A) that is less than logP A , the octanol / water partition coefficient of component (B) is logP B In this case, logP B and logP A Difference from (logP B -logP A ) is greater than or equal to -2.20 and less than or equal to 3.00. As used herein, the term "lower alcohol" refers to a monoalcohol having 4 or less carbon atoms, and includes methanol, ethanol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, sec-butyl alcohol, and tert-butyl alcohol. The logP B and logP A Difference from (logP B -logP A ) is preferably −2.15 or more, more preferably −1.80 or more, even more preferably −1.60 or more, still more preferably −1.20 or more, and is preferably 2.20 or less, more preferably 1.80 or less, even more preferably 1.50 or less, still more preferably 1.00 or less, still more preferably 0.60 or less, still more preferably 0.30 or less, and still more preferably 0.10 or less, from the viewpoints of improving the bactericidal performance, allowing component (A) to remain on the surface of an object for a long period of time when applied to the object, and improving compatibility with the skin surface. logP B is the logP A can be found in a similar manner.

[0024] When two or more components (B) are used, logP B is not a weighted average of all components (B), but the logP B and logP A The difference between the two must be in the range of -2.20 to 3.00.

[0025] In addition, the boiling point BP of component (B) B is the boiling point BP of component (A) from the viewpoint of allowing component (A) to remain on the surface of an object for a long period of time when applied to the object and improving the durability of the bactericidal performance of the composition. A It is preferable that the boiling point BP of component (B) is not too low. B and the boiling point BP of component (A) A Difference from (BP B -BP A ) is preferably -50°C or higher, more preferably -30°C or higher, even more preferably -20°C or higher, even more preferably -10°C or higher, and even more preferably -5°C or higher. (BP B -BP A ) is not particularly limited, but is usually 150° C. or less, preferably 120° C. or less, and more preferably 100° C. or less. The above boiling points are all measured at normal pressure (1 atm) and 25°C.

[0026] The composition of the present invention contains component (A) as an active ingredient of a disinfectant. From this viewpoint, component (B) is preferably a compound having no bactericidal activity.

[0027] Component (B) is preferably a compound having a hydroxy group and a molecular weight of 1,000 or less, and more preferably a polyol having a molecular weight of 1,000 or less, from the viewpoints of miscibility with component (A), allowing component (A) to remain on the surface of an object for a long period of time when applied to the object and thereby improving the durability of the bactericidal performance of the composition, and improving compatibility with the skin surface. The molecular weight of component (B) is more preferably 800 or less, even more preferably 500 or less, and even more preferably 300 or less. From the viewpoint of suppressing volatilization of component (B), it is preferably 50 or more, more preferably 70 or more.

[0028] The number of carbon atoms in component (B) is preferably 2 or more, and more preferably 3 or more, from the viewpoint of allowing component (A) to remain on the surface of an object for a long time when applied to the object and improving the durability of the bactericidal performance of the composition, and ... the number of carbon atoms in component (B) is preferably 36 or less, more preferably 28 or less, even more preferably 24 or less, still more preferably 18 or less, still more preferably 12 or less, and even more preferably 8 or less, from the viewpoint of allowing component (A) to remain on the surface of an object for a long time when applied to the object and improving the durability of the bactericidal performance of the composition and improving compatibility with the skin surface. The number of hydroxy groups in component (B) is preferably 2 or more and 5 or less, more preferably 2 or more and 4 or less, and even more preferably 2 or more and 3 or less, from the viewpoint of allowing component (A) to remain on the surface of an object for a long period of time when applied to the object, thereby improving the durability of the bactericidal performance of the composition, and from the viewpoint of improving compatibility with the skin surface.

[0029] The polyol used as component (B) may be a chain polyol or a polyol having a cyclic structure. The term "chain" in the chain polyol includes both straight chain and branched chain. Component (B) is preferably a chain polyol from the viewpoint of allowing component (A) to remain on the surface of an object for a long period of time when applied to the object, thereby improving the durability of the bactericidal performance of the composition, as well as from the viewpoint of improving compatibility with the skin surface. In the chain polyol, the bonding position of the hydroxy group is not particularly limited.

[0030] Specific examples of polyols used as component (B) include linear diols such as ethylene glycol, propylene glycol (1,2-propanediol), 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol (1,4-butanediol), 2,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-heptanediol, 1,7-heptanediol, 1,8-octanediol, 1,2-nonanediol, 1,9-nonanediol, 1,2-decanediol, 1,10-decanediol, 1,2-dodecanediol, 1,12-dodecanediol, 1,2-tetradecanediol, 1,2-hexadecanediol, 1,16-hexadecanediol, diethylene glycol, and triethylene glycol; Linear triols or tetraols such as glycerol, diglycerol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2,5-pentanetriol, 1,2,6-hexanetriol, 1,2,7-heptanetriol, 1,2,8-octanetriol, 1,2,9-nonanetriol, and 1,2,10-decanetriol; Branched diols or triols such as 2-methyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 3-methyl-1,3-butanediol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, tripropylene glycol, 2-butyl-2-ethyl-1,3-propanediol, (lauryl / myristyl) glycol hydroxypropyl ether, 3,7,11,15-tetramethylhexadecane-1,2,3-triol; and Polymers such as polyethylene glycol, polyglycerin, PPG-10 butanediol, etc., can be mentioned, and one or more of these can be used. Among the above, from the viewpoint of allowing component (A) to remain on the surface of an object for a long period of time when applied to the object, thereby improving the durability of the bactericidal performance of the composition, and from the viewpoint of improving compatibility with the skin surface, component (B) is preferably one or more selected from the group consisting of propylene glycol (1,2-propanediol), 1,3-butylene glycol, 1,4-butylene glycol (1,4-butanediol), diethylene glycol, triethylene glycol, glycerol, diglycerol, 1,2,6-hexanetriol, and 2-ethyl-1,3-hexanediol, and more preferably one or more selected from the group consisting of 1,4-butylene glycol (1,4-butanediol) and glycerol.

[0031] <Content> The content of component (A) in the composition of the present invention is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, even more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, even more preferably 0.7% by mass or more, even more preferably 1.0% by mass or more, even more preferably 2.0% by mass or more, from the viewpoint of improving the bactericidal performance, and from the viewpoint of making component (A) remain on the surface of the object for a long time when applied to the object and improving the durability of the bactericidal performance of the composition. Also, from the viewpoint of improving the compatibility of the composition with the skin surface, it is preferably 7.5% by mass or less, more preferably 6.0% by mass or less, even more preferably 5.0% by mass or less, even more preferably 4.0% by mass or less.

[0032] The content of component (B) in the composition of the present invention is preferably 0.4% by mass or more, more preferably 0.7% by mass or more, even more preferably 1.0% by mass or more, and even more preferably 1.5% by mass or more, from the viewpoint of allowing component (A) to remain on the surface of the object for a long time when applied to the object and improving the durability of the bactericidal performance of the composition. Also, from the viewpoint of improving the compatibility of the composition with the skin surface, the content is preferably 9.9% by mass or less, more preferably 8.0% by mass or less, even more preferably 6.0% by mass or less, and even more preferably 5.0% by mass or less.

[0033] The total content of component (A) and component (B) in the composition of the present invention is 3.0% by mass or more, preferably 3.4% by mass or more, more preferably 3.75% by mass or more, and even more preferably 4.0% by mass or more, from the viewpoint of improving the bactericidal performance and from the viewpoint of allowing component (A) to remain on the surface of the object for a long time when applied to the object and improving the durability of the bactericidal performance of the composition. Also, from the viewpoint of improving the compatibility of the composition with the skin surface, the total content is 10% by mass or less, preferably 9.0% by mass or less, more preferably 8.0% by mass or less, and even more preferably 7.0% by mass or less.

[0034] The mass ratio of component (A) to component (B) in the composition of the present invention [(A) / (B)] is 7.5 or less, preferably 5.0 or less, more preferably 4.0 or less, and even more preferably 3.0 or less, from the viewpoint of allowing component (A) to remain on the surface of the object for a long time when applied to the object and improving the durability of the bactericidal performance of the composition. Also, from the viewpoint of improving the bactericidal performance of the composition, it is preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.3 or more, even more preferably 0.5 or more, and even more preferably 0.7 or more.

[0035] <Water> It is preferred that the composition of the present invention further contains water from the viewpoint of dissolving the components (A) and (B) and from the viewpoint of facilitating application to a target object such as the skin surface. When the composition of the present invention contains water, the content of water in the composition varies depending on the formulation, but from the viewpoint of dissolving component (A) and component (B) and of facilitating application to a target object such as the skin surface, the content of water is preferably 1 mass % or more, more preferably 5 mass % or more, and even more preferably 10 mass % or more, and is 97 mass % or less.

[0036] <Aqueous medium> The composition of the present invention preferably further contains an aqueous medium other than water from the viewpoint of dissolving the components (A) and (B) and from the viewpoint of facilitating application to a target such as the skin surface. Examples of the aqueous medium include lower alcohols such as ethanol and isopropyl alcohol. Among these, ethanol is preferred from the viewpoint of miscibility with the components (A) and (B). When the composition of the present invention contains an aqueous medium, the content of the aqueous medium in the composition varies depending on the dosage form, but from the viewpoint of dissolving component (A) and component (B) and of facilitating application to a target object such as the skin surface, it is preferably 10% by mass or more, more preferably 20% by mass or more, even more preferably 30% by mass or more, still more preferably 40% by mass or more, still more preferably 50% by mass or more, and is 97% by mass or less. The content of water and the aqueous medium in the composition may be the balance of component (A) and component (B).

[0037] <Other ingredients> In addition to the above-mentioned components, the composition of the present invention may contain other components as necessary, such as surfactants, pH adjusters, thickeners, UV absorbers, antioxidants, preservatives, antiperspirants, fragrances, moisturizers, texture adjusters, and anti-inflammatory agents.

[0038] The composition of the present invention may contain a bactericide other than component (A), but the effect of the present invention can be achieved even if the content is small. The bactericide may be one or more selected from the group consisting of cationic bactericides, iodine bactericides, phenolic bactericides, biguanide bactericides, terpenoid bactericides, chlorine bactericides, and amphoteric surfactant bactericides. These bactericides are preferably used in skin external preparation compositions.

[0039] Examples of cationic disinfectants include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, alkyltrimethylammonium chloride, and dialkyldimethylammonium chloride. Examples of iodine-based disinfectants include povidone iodine, polyvinyl alcohol iodine, and cyclodextrin iodine. Phenol-based disinfectants include isopropylmethylphenol, triclosan, and phenoxyethanol. Biguanide disinfectants include chlorhexidine gluconate. Terpenoid fungicides include dipotassium glycyrrhizinate, stearyl glycyrrhetinate, and β-glycyrrhetinic acid. Examples of chlorine-based disinfectants include hypochlorous acid, sodium hypochlorite, calcium hypochlorite, and chlorinated isocyanuric acid. Examples of amphoteric surfactant-based disinfectants include alkyldiaminoethylglycine hydrochloride and alkylpolyaminoethylglycine.

[0040] From the viewpoint of suppressing skin irritation and from the viewpoint of economy, the content of the bactericide in the composition of the present invention is preferably 5.0% by mass or less, more preferably 3.0% by mass or less, even more preferably 1.0% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, even more preferably 0.07% by mass or less, even more preferably 0.05% by mass or less, and may be essentially 0% by mass.

[0041] <Dosage form> The formulation of the composition is not particularly limited, but from the viewpoint of ease of application to the target object, it is preferable that the composition is in the form of a liquid, gel, or cream. The composition of the present invention may also be in the form of an emulsion composition, and the emulsion composition may be either an oil-in-water emulsion composition or a water-in-oil emulsion composition.

[0042] As described above, the composition of the present invention is preferably a leave-on disinfectant composition for skin, and more preferably a leave-on disinfectant composition for hands.Preferable dosage forms include, for example, stick preparations with a solid composition; roll-on preparations or spray preparations filled with a liquid composition; preparations filled with a liquid, gel or cream composition in a bottle, tube, dispenser-type container, etc., and sheet products impregnated with the composition.

[0043] [How to disinfect the skin] The present invention also provides a method of disinfecting skin comprising the step of applying to the skin a leave-on disinfectant composition of the present invention. The method for applying the composition to the skin can be appropriately selected depending on the application site, etc., and for example, the composition can be applied by painting or spraying it onto the skin surface.

[0044] In the above method, it is preferable that after applying the leave-on disinfectant composition to the skin, the composition is not removed by washing with water or the like, but is allowed to remain on the skin surface, in order to achieve the bactericidal activity and its persistence by using the composition as a leave-on disinfectant composition and allowing the bactericidal components, component (A) and component (B), to remain on the skin surface.

[0045] In the step of applying the composition to the skin, the amount of the composition to be applied is not particularly limited. From the viewpoint of exhibiting high bactericidal performance, the composition is usually applied in an amount of preferably 0.1 mL to 5 mL per palm.

[0046] The composition may be applied to the skin after washing the skin in advance with water, soap, body soap, hand soap, etc., or may be applied to unwashed skin. Since the skin after washing is in a state in which the naturally existing protective components of the skin have been washed away and the defense power against bacteria and viruses present in the external environment is reduced, it is more preferable to apply the composition to the skin after washing.

[0047] [How to maintain the bactericidal effect] The present invention further provides a method for sustaining the bactericidal effect of a polyol (A) having bactericidal properties, comprising a step of using the component (A) and a compound (B) other than the component (A), the component (B) being such that the octanol / water partition coefficient of the component (A) is less than logP A The octanol / water partition coefficient of the component (B) is logP B In this case, logP B and logP A Difference from (logP B -logP A ) is greater than or equal to -2.20 and less than or equal to 3.00. The specific polyol (A) can maintain the bactericidal effect by combining it with the compound (B) in a specific ratio based on the above-mentioned mechanism of action. In the above, the polyol (A), the compound (B), and the preferred embodiments thereof are the same as those described above. In the step of using component (A) and component (B), for example, the above-mentioned leave-on disinfectant composition can be used. Alternatively, in the step, component (A) and component (B) may be prepared separately and mixed just before application to the object, or component (A) and component (B) may be applied separately to the object and brought into contact with each other on the surface of the object.

[0048] The mass ratio of component (A) to component (B) [(A) / (B)], from the viewpoint of sustaining the bactericidal effect of component (A), is 7.5 or less, preferably 5.0 or less, more preferably 4.0 or less, even more preferably 3.0 or less, and is preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.3 or more, still more preferably 0.5 or more, and even more preferably 0.7 or more.

[0049] When the leave-on disinfectant composition is used in the method of the present invention, the total content of component (A) and component (B) in the composition is preferably 3.0% by mass or more, more preferably 3.4% by mass or more, even more preferably 3.75% by mass or more, and even more preferably 4.0% by mass or more. Also, it is preferably 10% by mass or less, more preferably 9.0% by mass or less, even more preferably 8.0% by mass or less, and even more preferably 7.0% by mass or less. EXAMPLES

[0050] The present invention will be described below with reference to examples, but the present invention is not limited to the scope of the examples. In the examples, various measurements and evaluations were carried out by the following methods.

[0051] (Residual amount of component (A)) The frosted glass was placed on a hot plate set at 30° C., and the leave-on disinfectant composition of each example was applied to the frosted glass using a spatula for 30 seconds (application amount: 15 μL / 7.5 cm 2 After leaving it in this state for 30 minutes, the residue on the frosted glass was extracted with 1 mL of ethanol. The ethanol extract was analyzed by gas chromatography to determine the amount of component (A) remaining on the glass surface (mg / cm 2 ) was sought. [GC measurement conditions] Measuring device: Agilent GC system “Aglient 6850” Column: Agilent J&W GC column DB-1 Carrier: Helium Flow rate: 2mL / min Injection volume: 2μL Column temperature: After maintaining at 60°C for 2 minutes, the temperature was increased to 270°C at 15°C / min and maintained at 270°C for 10 minutes. Detector: FID

[0052] (Easy to blend into skin) The palms and backs of the hands of the subjects were washed with "Biore U Foaming Hand Soap" (manufactured by Kao Corporation). After thoroughly wiping off the water, the subjects were left to stand for about 1 to 2 minutes. 1 mL (1 μL / cm ) of the composition shown in Tables 2 to 4 was applied. 2 The time it took for the skin to feel absorbed into the skin was measured. The measured time was scored as follows: 5: Absorbed into skin within 60 seconds 4: Absorbed into skin within 80 seconds 3. Absorbed into skin within 100 seconds 2: Absorbed into skin within 20 seconds 1:1 Did not blend into skin within 20 seconds

[0053] Reference Examples 1 to 8 (Evaluation of the bactericidal performance of component (A)) A composition for evaluation was prepared by blending the components in the amounts shown in Table 1 and mixing at room temperature. The blending amounts shown in Table 1 are the active ingredient amounts (mass %) of each component. The obtained composition for evaluation was used to evaluate the bactericidal performance of the component (A) used in this example by the following method.

[0054] (Preparation of bacterial solution) For the evaluation of bactericidal activity, a bacterial suspension of enterococci prepared by the following method was used. Enterococcus hirae Farrow and Collins 1985 NBRC3181 strain (National Institute of Technology and Evaluation) was used as the enterococcus. This bacterium was cultured in LB liquid medium, the bacterial cells were collected by centrifugation, and the OD was measured using pure water. 600 was adjusted to be 10.

[0055] (Bactericidal evaluation) 15 μL of the composition described in Table 1 was applied to a frosted glass surface (7.5 cm 2 The component (A) was applied uniformly to the entire surface (range) of the substrate (A) so that the amount of component (A) applied was the amount shown in Table 1. After leaving the composition to stand for 5 minutes and drying, a fixed amount (7.5 μL / 7.5 cm ) of the enterococcus liquid prepared by the above method was applied to the glass surface after application of the composition. 2After leaving the plate in this state for 10 minutes, the applied bacterial liquid was collected using two swabs. Next, the number of viable bacteria was measured using an incubation reader "Infinite pro" (manufactured by TECAN) by the method described below, and the reduction in the number of bacteria (number of viable bacteria / initial number of viable bacteria) was confirmed. The liquid was cultured at 37°C in an incubation reader "Infinite pro," and the absorbance (turbidity) at a wavelength of 600 nm was measured over time to create a growth curve of the number of viable bacteria in the bacterial liquid. At the same time, a bacterial liquid with a known number of viable bacteria was serially diluted, and cultured and a growth curve was created in the same way, and a calibration curve of the time to reach a certain turbidity and the number of viable bacteria was created. From the relationship between the time to reach a certain turbidity for each sample and the calibration curve, the number of viable bacteria in the collected bacterial liquid was estimated, and the amount of reduction in the number of bacteria was confirmed. The degree of reduction in the number of bacteria (log reduction value) was calculated by taking the -log value of the reduction in the number of bacteria, and this value was designated as a. Next, compositions were prepared by removing component (A) from the compositions of Reference Examples 1 to 8, and the bactericidal activity was evaluated in the same manner as above to determine the log reduction value. This value was designated b. The value ab is shown in Table 1 as the "bactericidal activity value." A larger value indicates higher bactericidal activity.

[0056] [Table 1]

[0057] As shown in Table 1, the component (A) used in this example is 0.01 mg / cm 2 The difference (ab) between the logarithmic reduction value a of the number of bacteria when the composition is used in an amount equal to or greater than the logarithmic reduction value b of the number of bacteria when the same amount of a composition in which component (A) is removed from the composition is used is 0.50 or more (Reference Examples 1 and 7), indicating that the composition has bactericidal performance.

[0058] Examples 1 to 21 and Comparative Examples 1 to 5 (Preparation and Evaluation of Leave-On Disinfectant Compositions) The leave-on disinfectant compositions of each example were prepared by blending the components in the amounts shown in Tables 2 to 4 and mixing at room temperature. The blending amounts shown in Tables 2 to 4 are the active ingredient amounts (mass%) of each component. The obtained leave-on disinfectant compositions were evaluated by the above-mentioned methods. The results are shown in Tables 2 to 4.

[0059] [Table 2]

[0060] [Table 3]

[0061] [Table 4]

[0062] The ingredients listed in the table are as follows: <Component (A)> *1: Dipropylene glycol: "Dipropylene glycol (mixture of isomers)" manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *2 1,2-Hexanediol, manufactured by Tokyo Chemical Industry Co., Ltd.

[0063] <Ingredient (B)> *3: Glycerol "Glycerin" manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *4: 1,4-butanediol, Fujifilm Wako Pure Chemical Industries, Ltd. *5: 1,3-butylene glycol, Fujifilm Wako Pure Chemical Industries, Ltd. *6: Triethylene glycol manufactured by Tokyo Chemical Industry Co., Ltd. *7: Diethylene glycol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *8: 1,2,6-Hexanetriol, Fujifilm Wako Pure Chemical Industries, Ltd. *9: 2-Ethyl-1,3-hexanediol "2-Ethyl-1,3-hexanediol (mixture of isomers)" manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *10: Diglycerol, manufactured by Tokyo Chemical Industry Co., Ltd. *11: 1,2-Propanediol, manufactured by Tokyo Chemical Industry Co., Ltd.

[0064] <Component (B'): Compound other than components (A) and (B)> *12:1-Decanol Fujifilm Wako Pure Chemical Industries, Ltd. *13: Sorbitol: Mitsubishi Corporation Life Sciences Co., Ltd. "Sorbit D-70" (70% sorbitol, 30% water)

[0065] From Tables 2 to 4, it is clear that the leave-on disinfectant composition of this Example has a large residual amount of component (A), which is a bactericidal component, and is easily absorbed into the skin. [Industrial Applicability]

[0066] According to the present invention, a leave-on disinfectant composition can be provided which has bactericidal properties, is capable of leaving a bactericidal component on the surface of an object for a long period of time when applied to the object, and is easily absorbed into the skin surface when applied to the skin.

Claims

1. Component (A): a polyol having bactericidal properties, and Component (B): A leave-on disinfectant composition containing a compound other than component (A) (excluding water and lower alcohols), The component (B) is a compound having an octanol / water partition coefficient of the component (A) that is equal to or greater than log P A The octanol / water partition coefficient of the component (B) is log P B In this case, logP B and logP A The difference between B -logP A ) is equal to or greater than -2.20 and equal to or less than 3.00, the total content of the component (A) and the component (B) in the composition is 3.0% by mass or more and 10% by mass or less, A leave-on disinfectant composition, wherein the mass ratio of component (A) to component (B) [(A) / (B)] is 7.5 or less.

2. The log P A The leave-on disinfectant composition of claim 1, wherein the β-glucan value is -3.00 or greater.

3. The leave-on disinfectant composition according to claim 1, wherein the component (A) is a chain polyol having from 4 to 12 carbon atoms.

4. The leave-on disinfectant composition according to claim 1, wherein the component (A) is at least one selected from the group consisting of dipropylene glycol and 1,2-hexanediol.

5. The boiling point BP of the component (B) B and the boiling point BP of the component (A). A Difference from (BP B -BP A 2. The leave-on disinfectant composition of claim 1, wherein the temperature is −30° C. or higher.

6. 2. The leave-on disinfectant composition according to claim 1, wherein component (B) is a compound having a hydroxy group and a molecular weight of 1,000 or less.

7. The leave-on disinfectant composition according to claim 6, wherein the number of hydroxy groups in component (B) is 2 or more and 4 or less.

8. The leave-on disinfectant composition of claim 1, further comprising an aqueous medium other than water.

9. A method for disinfecting skin, comprising the step of applying to the skin a leave-on disinfectant composition according to any one of claims 1 to 8.

10. A method for sustaining the bactericidal effect of a polyol (A) having bactericidal properties, comprising: The method includes a step of using the component (A) and a compound (B) other than the component (A) (excluding water and lower alcohols), The component (B) is a compound having an octanol / water partition coefficient of the component (A) that is equal to or greater than log P A The octanol / water partition coefficient of the component (B) is log P B In this case, logP B and logP A The difference between B -logP A ) is equal to or greater than -2.20 and equal to or less than 3.00, The method, wherein the mass ratio of component (A) to component (B) [(A) / (B)] is 7.5 or less.