Pyridazinone compounds and uses thereof

Abstract

Disclosed herein are substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne muscular dystrophy (DMD).The disclosed compounds are useful, inter alia, for treating DMD and regulating inflammatory inhibitors IL-1, IL-6, or TNF-α.In certain aspects, the disclosure provides a method for treating neuromuscular conditions through selective inhibition of fast-twitch fiber skeletal muscle myosin.In particular, the disclosed method can be used in the treatment of DMD and other neuromuscular conditions.

Description

[Technical field]

[0001] cross reference This application claims the benefit of U.S. Provisional Application No. 63 / 280,457, filed November 17, 2021, which is incorporated by reference in its entirety. [Background technology]

[0002] Skeletal muscle is the largest organ system in the human body that serves two primary purposes. The first is the generation of force that allows muscle contraction, locomotor activity, and posture maintenance; the second is the metabolism of glucose, fatty acids, and amino acids. Contraction of skeletal muscles during daily activities and exercise naturally leads to muscle stress, breakdown, and remodeling, which is important for muscle adaptation. In individuals with neuromuscular conditions (e.g., Duchenne muscular dystrophy (DMD)), muscle contraction leads to successive rounds of amplified muscle breakdown that the body struggles to repair. Ultimately, as patients age, pathophysiological processes emerge that lead to excessive inflammation, fibrosis, and accumulation of fat deposits in muscle, presaging a rapid decline in physical function and a contribution to mortality.

[0003] DMD is a genetic disorder that affects skeletal muscles and is characterized by progressive muscle degeneration and weakness. There remains a need for treatments that reduce muscle destruction in patients with neuromuscular conditions (e.g., DMD). Summary of the Invention [Means for solving the problem]

[0004] Summary of the Invention As used herein, the compounds of formula (Ia) or (Ib): [ka] or a salt thereof, wherein Y 1 is N or CR 4 and R1 teeth, hydrogen, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 3~10Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from R 2 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6, -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and -C(O)NR 7 R 8 is selected from Each R 3 is halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 , -CN, and halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 4 is hydrogen, halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 , -CN, and halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, Each R 5 teeth, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6, -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), and -CN, are independently selected from Each R 6 teeth, hydrogen, C 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 7 represents hydrogen, as well as halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, R 8 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R6 ), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from p is 0, 1, or 2].

[0005] As used herein, the compound of formula (II): [ka] or a salt thereof, wherein Y 11 is N or CR 14 and R 11 teeth, hydrogen, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16, -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from R 12 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from Each R 13 is halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 14 is hydrogen, halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 15 teeth, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, are independently selected from Each R 16 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 17 represents hydrogen, as well as halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2].

[0006] As used herein, the compound of formula (III): [ka] or a salt thereof, wherein R 21 teeth, hydrogen, Halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , and -CN, C 2~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 (each replaced as necessary) is selected from R 22 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 (each replaced as necessary) is selected from Each R 23 is halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -NO 2 , -CN, and halogens, -OR 26 , -SR 26 , -N(R 26 ) 2 , -NO 2and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 25 teeth, Halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O)2 R 26 , -NO 2 , =O, =S, =N(R 26 ), and -CN, are independently selected from Each R 26 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from p is 0, 1, or 2].

[0007] As used herein, the compound of formula (IV): [ka] or a salt thereof, wherein R 31 teeth, hydrogen, Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2, =O, =S, =N(R 36 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 (each replaced as necessary) is selected from R 32 teeth, C 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each being replaced as necessary), and Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R36 ), and -CN, C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each of which is optionally substituted with one or more substituents independently selected from is selected from Each R 33 is halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2 , -CN, and halogens, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 34 is hydrogen, halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2 , -CN, and halogens, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 35 teeth, Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36, -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), and -CN, are independently selected from Each R 36 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from p is 0, 1, or 2].

[0008] As used herein, the formula (V): [ka] or a salt thereof, wherein X 41 is O or S, R 41 teeth, hydrogen, Halogen, -OR 46 , -SR 46 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from R 42 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2, -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45each being replaced as necessary), and -C(O)NR 47 R 48 is selected from Each R 43 is halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 , -CN, and halogens, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 45 teeth, Halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46, -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, are independently selected from Each R 46 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 47 represents hydrogen, as well as halogens, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, R 48 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from p is 0, 1, or 2].

[0009] As used herein, the compound of formula (VI): [ka] or a salt thereof, wherein X 51 is selected from O and S; R 51 teeth, hydrogen, Halogen, -OR 56, -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from R 52 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 )2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from Each R 53 is halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN; halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 54 is hydrogen, halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings are preferably substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 -, and -CN, each optionally substituted with one or more substituents independently selected from Each R 55 teeth, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56, -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, are independently selected from Each R 56 teeth, hydrogen, C 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 57 represents hydrogen, as well as halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, [p is 0, 1, or 2].

[0010] As used herein, the compound of formula (VII): [ka] or a salt thereof, wherein R 61 teeth, hydrogen, Halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R66 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 (each replaced as necessary) is selected from R 62 teeth, Halogen, -OR 66 , -SR66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), and -CN, C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 each of which is optionally substituted with is selected from Each R 63 is halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -NO 2 , -CN, and halogens, -OR 66 , -SR 66 , -N(R 66 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 65 teeth, Halogen, -OR 66 , -SR 66 , -N(R 66 )2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), and -CN, are independently selected from Each R 66 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from [p is 0, 1, or 2].

[0011] As used herein, the compound of formula (VIII): [ka] or a salt thereof, wherein X 71 is selected from S and O; R 71 teeth, hydrogen, Halogen, -OR 76 , -SR 76, -N(R 76 ) 2 , -C(O)R 76 , -C(O)N(R 76 ) 2 , -N(R 76 )C(O)R 76 , -C(O)OR 76 , -OC(O)R 76 , -N(R 76 )C(O)N(R 76 ) 2 , -OC(O)N(R 76 ) 2 , -N(R 76 )C(O)OR 76 , -S(O)R 76 , -S(O) 2 R 76 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 76 , -SR 76 , -N(R 76 ) 2 , -C(O)R 76 , -C(O)N(R 76 ) 2 , -N(R 76 )C(O)R 76 , -C(O)OR 76 , -OC(O)R 76 , -N(R 76 )C(O)N(R 76 ) 2 , -OC(O)N(R 76 ) 2 , -N(R 76 )C(O)OR 76 , -S(O)R 76 , -S(O) 2 R 76 , -NO 2 , =O, =S, =N(R 76 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R75 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 76 , -SR 76 , -N(R 76 ) 2 , -C(O)R 76 , -C(O)N(R 76 ) 2 , -N(R 76 )C(O)R 76 , -N(R 76 )C(O)N(R 76 ) 2 , -OC(O)N(R 76 ) 2 , -N(R 76 )C(O)OR 76 , -C(O)OR 76 , -OC(O)R 76 , -S(O)R 76 , -S(O) 2 R 76 , -NO 2 , =O, =S, =N(R 76 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 75 (each replaced as necessary) is selected from R 72 teeth, Halogen, -OR 76 , -SR 76 , -N(R 76 ) 2 , -C(O)R 76 , -C(O)N(R 76 ) 2 , -N(R 76 )C(O)R76 , -N(R 76 )C(O)N(R 76 ) 2 , -OC(O)N(R 76 ) 2 , -N(R 76 )C(O)OR 76 , -C(O)OR 76 , -OC(O)R 76 , -S(O)R 76 , -S(O) 2 R 76 , -NO 2 , =O, =S, =N(R 76 ), and -CN, C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 75 each of which is optionally substituted with one or more substituents independently selected from is selected from Each R 73 is halogen, -OR 76 , -SR 76 , -N(R 76 ) 2 , -NO 2 , -CN, and halogens, -OR 76 , -SR 76 , -N(R 76 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 74 is hydrogen, halogen, -OR 76 , -SR 76 , -N(R 76 ) 2 , -NO 2 , -CN, and halogens, -OR 76 , -SR 76 , -N(R 76 ) 2 , -NO 2and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 75 teeth, Halogen, -OR 76 , -SR 76 , -N(R 76 ) 2 , -C(O)R 76 , -C(O)N(R 76 ) 2 , -N(R 76 )C(O)R 76 , -N(R 76 )C(O)N(R 76 ) 2 , -OC(O)N(R 76 ) 2 , -N(R 76 )C(O)OR 76 , -C(O)OR 76 , -OC(O)R 76 , -S(O)R 76 , -S(O) 2 R 76 , -NO 2 , =O, =S, =N(R 76 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 76 , -SR 76 , -N(R 76 ) 2 , -C(O)R 76 , -C(O)N(R 76 ) 2 , -N(R 76 )C(O)R 76 , -N(R 76 )C(O)N(R 76 ) 2 , -OC(O)N(R 76 ) 2 , -N(R 76 )C(O)OR 76 , -C(O)OR 76 , -OC(O)R 76 , -S(O)R 76 , -S(O)2 R 76 , -NO 2 , =O, =S, =N(R 76 ), and -CN, are independently selected from Each R 76 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from p is 0, 1, or 2].

[0012] Disclosed herein are pharmaceutical compositions comprising the compounds or salts provided herein.

[0013] Disclosed herein is a method for treating neuromuscular conditions or movement disorders, comprising administering a compound or salt provided herein to a subject in need thereof.In some embodiments, the neuromuscular condition is selected from Duchenne muscular dystrophy, Becker muscular dystrophy, myotonic dystrophy type 1, myotonic dystrophy type 2, facioscapulohumeral muscular dystrophy, oculopharyngeal muscular dystrophy, limb-girdle muscular dystrophy, tendonitis, and carpal tunnel syndrome.In some embodiments, the neuromuscular condition is Duchenne muscular dystrophy.In some embodiments, the movement disorder comprises muscle spasms.In some embodiments, the muscle spasms are selected from spasticity associated with multiple sclerosis, Parkinson's disease, Alzheimer's disease, or cerebral palsy, or injury, or traumatic event, such as stroke, traumatic brain injury, spinal cord injury, hypoxia, meningitis, encephalitis, phenylketonuria, or amyotrophic lateral sclerosis. References

[0014] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] Detailed Description of the Invention While preferred embodiments of the present invention have been shown and described herein, it will be apparent to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions may now occur to those skilled in the art without departing from the invention. It should be understood that various modifications to the embodiments of the invention described herein may be used in practicing the invention. It is intended that the following claims define the scope of the invention, and that methods and structures within the scope of these claims and their equivalents be covered thereby.

[0016] In certain aspects, the present disclosure provides methods for treating neuromuscular conditions through selective inhibition of fast fiber skeletal muscle myosin. In particular, the methods of the present disclosure can be used in the treatment of DMD and other neuromuscular conditions.

[0017] Skeletal muscle is mainly composed of two types of fibers, slow-twitch fibers (i.e., type I) and fast-twitch fibers (i.e., type II). In each muscle, the two types of fibers are arranged in a mosaic-like arrangement, with differences in the composition of fiber types in different muscles and at different times in growth and development. Slow-twitch fibers have superior aerobic energy generation capacity. Slow-twitch fibers have a slower contraction rate but are more fatigue-resistant. Slow-twitch fibers typically have higher concentrations of mitochondria and myoglobin than fast-twitch fibers, and are surrounded by more capillaries than fast-twitch fibers. Although slow-twitch fibers contract at a lower rate and produce a lower power rate compared to fast-twitch fibers due to lower myosin ATPase activity, they can maintain contractile function for a longer period of time, for example, in stabilization, postural control, and endurance exercises.

[0018] Fast-twitch fibers in humans are further divided into two major fiber types depending on the specific skeletal fast-twitch myosin (type IIA, type IIx / d) they express. A third type of fast-twitch fiber (type IIB) exists in other mammals but has rarely been identified in human muscle. Fast-twitch fibers have superior anaerobic energy-generating capacity and can generate large amounts of tension for short periods of time. Typically, fast-twitch fibers have lower concentrations of mitochondria, myoglobin, and capillaries compared to slow-twitch fibers and therefore can fatigue more quickly. Fast-twitch fibers generate the force required for power and resistance activities more quickly.

[0019] The proportion of types I and II may vary in different individuals. For example, a non-athlete individual may have close to 50% of each muscle fiber type. Power athletes may have a higher proportion of fast twitch fibers, e.g., 70-75% type II in sprinters. Endurance athletes may have a higher proportion of slow twitch fibers, e.g., 70-80% in long distance runners. The proportion of types I and II may also vary depending on the age of the individual. The proportion of type II fibers, especially type IIx fibers, may decrease as an individual ages, resulting in a loss of lean muscle mass.

[0020] Contraction of skeletal muscle leads to muscle damage in subjects with neuromuscular diseases (e.g., DMD), and this damage appears to be more pronounced in fast-twitch fibers. In dystrophic mouse models, rapid muscle weakness after lengthening injury is observed to be more prevalent in fast-twitch fibers, primarily type II fibers, compared with slow-twitch fibers, primarily type I fibers. It has also been shown that the degree of rapid muscle weakness and tissue damage in dystrophic mouse models is proportional to the peak of muscle strength that occurs during lengthening injury. Excessive contraction-induced injury occurs prior to the inflammation and irreversible fibrosis that characterize the pathology of late-stage DMD. Contraction-induced muscle injury in these patients could conceivably be reduced by limiting the peak of muscle force generation in type II fibers and increasing the reliance on healthier type I fibers. N-benzyl-p-tolyl-sulfonamide (BTS), an inhibitor of skeletal fast-twitch fiber myosin, has been shown to protect muscle from pathological muscle disorganization in embryos from a zebrafish model of DMD.

[0021] Inhibitors of skeletal muscle myosin that are not selective for type II fibers may result in excessive inhibition of skeletal muscle contraction and unwanted inhibition of skeletal muscle contraction, including respiratory function. Because the heart shares some structural components (e.g., type I myosin) with type I skeletal muscle fiber. Without being bound to a particular mechanistic theory, the present disclosure provides selective inhibitors of fast-twitch fiber skeletal muscle myosin as a treatment option for Becker muscular dystrophy (BMD), Duchenne muscular dystrophy (DMD), limb-girdle muscular dystrophy (LGMD), McArdle's disease, and other neuromuscular conditions. Targeted inhibition of type II skeletal muscle myosin may reduce skeletal muscle contraction while minimizing the impact on the subject's daily activities.

[0022] When unaccustomed, excessive exercise is imposed on healthy muscles, it results in pain and a persistent decrease in strength and range of motion. In addition, proteins including creatine kinase (CK), lactate dehydrogenase, and myoglobin leak into the circulation from damaged muscle fibers. These biomarkers are not unique to either fast-twitch or slow-twitch fibers and therefore do not provide details regarding the differential response of fibers to injury. Troponin I (TNNI) is a component of the troponin complex that controls calcium-induced initiation of muscle contraction. Different isoforms exist for each type of striated muscle, with distinct differences in that TNNI1 is present in slow-twitch skeletal muscle, TNNI2 in fast-twitch skeletal muscle, and TNNI3 in cardiac muscle. It was demonstrated using selective enzyme-linked immunosorbent assay (ELISA) that TNNI2, but not TNNI1, is elevated in the circulation after injurious exercise even under demanding conditions.

[0023] DMD and BMD are caused by the absence (DMD) or truncation (BMD) of the dystrophin protein. 5Dystrophin provides a structural link between the actin cytoskeleton and the basement membrane through the dystrophin-glycoprotein complex. When dystrophin is absent or truncated, muscle contraction increases muscle tension and injury with normal use. Although susceptibility to injury is much higher in DMD muscles than in BMD or healthy muscles, fast-twitch fibers still appear to be more susceptible than slow-twitch fibers, and young DMD patients have a higher incidence of fast-twitch fiber destruction. 7 and histological evidence of early loss of type IIx fibers. Example 10 shows the relative susceptibility of these fibers to leaking muscle contents, such as troponin, creatine kinase, or myoglobin. In some embodiments, the present disclosure provides selective inhibitors of fast fiber skeletal muscle myosin as a treatment option for DMD, BMD, McArdle's disease, or limb-girdle muscular dystrophy. definition

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0025] As used in this specification and claims, the singular forms "a," "an," and "the" include plural references unless the context clearly dictates otherwise. x~y " or "C x ~C y " (when used with a chemical moiety such as, for example, alkyl, alkenyl, or alkynyl) means that the chemical moiety includes groups that contain a number of carbon atoms, from x or more carbon atoms to y or less carbon atoms. x~y " or "C x ~C y " is not meant to limit the number of carbon atoms that may be attached to a chemical moiety when that chemical moiety is substituted with a second chemical moiety. For example, the term "C 1~6 Alkyl" or "C 1 ~C 6"Alkyl" refers to substituted or unsubstituted saturated hydrocarbon groups, including straight chain alkyl groups (e.g., linear alkyl groups) and branched alkyl groups, containing 1, 2, 3, 4, 5, or 6 carbon atoms; 1~6 Any number of carbon atoms may be present in any of the alkyl substituents. For example, C 1~6 When the alkyl is optionally substituted with a second chemical moiety that contains two carbon atoms, C 1~6 It will be understood that an alkyl can contain between 1 and 8 carbon atoms.

[0026] The term “C x~y alkenyl" and "C x~y "Alkynyl" refers to substituted or unsubstituted unsaturated aliphatic groups analogous in length and possible substitution to the alkyls described above, but which contain at least one double or triple bond respectively.

[0027] "Amino" is -NH 2 Refers to a part.

[0028] "Cyano" refers to a -CN moiety.

[0029] "Nitro" is -NO 2 Refers to a part.

[0030] "Oxa" refers to an --O-- moiety.

[0031] "Oxo" refers to the moiety =O.

[0032] "Thioxo" refers to the moiety =S.

[0033] "Imino" refers to the =NH moiety.

[0034] "Oximo" refers to the =N-OH moiety.

[0035] "Hydrazino" is =N-NH 2 Refers to a part.

[0036] "Alkyl" refers to a linear or branched hydrocarbon moiety that is fully saturated, consisting solely of carbon and hydrogen atoms. In certain embodiments, an "alkyl" contains 1 to 15 carbon atoms (e.g., C 1 ~C 15 In certain embodiments, alkyl comprises 1 to 13 carbon atoms (e.g., C 1 ~C 13 In certain embodiments, alkyl comprises 1 to 8 carbon atoms (e.g., C 1 ~C 8 In certain embodiments, alkyl contains 1 to 6 carbon atoms (e.g., C 1 ~C 6 In other embodiments, alkyl contains 1 to 5 carbon atoms (e.g., C 1 ~C 5 In other embodiments, alkyl contains 1 to 4 carbon atoms (e.g., C 1 ~C 4 In other embodiments, alkyl contains 1 to 3 carbon atoms (e.g., C 1 ~C 3 In other embodiments, alkyl contains 1 to 2 carbon atoms (e.g., C 1 ~C 2 In other embodiments, an alkyl group contains one carbon atom (e.g., C 1 In other embodiments, the alkyl group contains 5 to 15 carbon atoms (e.g., C 5 ~C 15 In other embodiments, alkyl contains 5 to 8 carbon atoms (e.g., C 5 ~C 8 In other embodiments, alkyl contains 2 to 5 carbon atoms (e.g., C 2 ~C 5 In other embodiments, alkyl contains 3 to 5 carbon atoms (e.g., C 3 ~C 5In other embodiments, the alkyl group is selected from methyl, ethyl, 1-propyl (n-propyl), 1-methylethyl (2-propyl, iso-propyl), 1-butyl (n-butyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert-butyl), and 1-pentyl (n-pentyl). The alkyl is attached to the remainder of the molecule by a single bond.

[0037] "Aminoalkyl" refers to a moiety attached through a nitrogen atom of the form -N(H)(alkyl) or -N(alkyl)(alkyl), where the moiety is N(alkyl)(alkyl), the two alkyl groups attached to the nitrogen can be the same or different alkyl groups.

[0038] "Alkoxy" refers to a moiety attached through an oxygen atom of the formula -O-alkyl, where alkyl is an alkyl chain as defined above.

[0039] "Alkenyl" refers to a linear or branched hydrocarbon moiety consisting solely of carbon and hydrogen atoms containing at least one carbon-carbon double bond. In certain embodiments, an alkenyl contains 2-12 carbon atoms. In certain embodiments, an alkenyl contains 2-8 carbon atoms. In other embodiments, an alkenyl contains 2-4 carbon atoms. An alkenyl is attached to the remainder of the molecule by a single bond, for example, ethenyl (i.e., vinyl), prop-1-enyl (i.e., allyl), but-1-enyl, pent-1-enyl, penta-1,4-dienyl, and the like.

[0040] "Alkynyl" refers to a linear or branched hydrocarbon moiety consisting solely of carbon and hydrogen atoms, containing at least one carbon-carbon triple bond, having 2 to 12 carbon atoms, and optionally further containing at least one carbon-carbon double bond. In certain embodiments, an alkynyl contains 2 to 8 carbon atoms. In other embodiments, an alkynyl contains 2 to 6 carbon atoms. In other embodiments, an alkynyl contains 2 to 4 carbon atoms. An alkynyl is attached to the remainder of the molecule by a single bond, for example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like.

[0041] An "alkylene" or "alkylene chain" refers to a divalent hydrocarbon moiety that is linear (e.g., straight) or branched. An "alkylene" or "alkylene chain" can link one part of a molecule to a second part. An "alkylene" or "alkylene chain" consists of only carbon and hydrogen atoms (substitution of an alkylene with one or more substituents containing atoms other than hydrogen, such as N, O, and S, can be specified). An "alkylene" or "alkylene chain" can contain no unsaturation (even if it is the point of attachment of the alkylenne to the rest of the molecule). In certain embodiments, an "alkylene" or "alkylene chain" contains 1 to 12 carbon atoms, such as methylene, ethylene, propylene, n-butylene, etc. An alkylene chain can be attached to one part of a molecule through one single bond and to a second part through one single bond. The points of attachment of the alkylene chain to the rest of the molecule and to the second moiety can be through one carbon within the alkylene chain or through any two carbons within the alkylene. In certain embodiments, the alkylene contains 1 to 8 carbon atoms (e.g., C 1 ~C 8 In other embodiments, the alkylene contains 1 to 5 carbon atoms (e.g., C 1 ~C 5 In other embodiments, the alkylene contains 1 to 4 carbon atoms (e.g., C 1 ~C 4In other embodiments, the alkylene contains 1 to 3 carbon atoms (e.g., C 1 ~C 3 In other embodiments, the alkylene contains 1 to 2 carbon atoms (e.g., C 1 ~C 2 In other embodiments, the alkylene contains one carbon atom (e.g., C 1 In other embodiments, the alkylene contains 5 to 8 carbon atoms (e.g., C 5 ~C 8 In other embodiments, the alkylene contains 2 to 5 carbon atoms (e.g., C 2 ~C 5 In other embodiments, the alkylene contains 3 to 5 carbon atoms (e.g., C 3 ~C 5 alkylene).

[0042] An "alkenylene" or "alkenylene chain" refers to a linear (e.g., straight) or branched divalent hydrocarbon moiety. An "alkenylene" or "alkenylene chain" can link one part of a molecule to a second part. An "alkenylene" or "alkenylene chain" consists of only carbon and hydrogen atoms (substitution of an alkenylene with one or more substituents containing atoms other than hydrogen, such as N, O, and S, can be specified). An "alkenylene" or "alkenylene chain" contains at least one carbon-carbon double bond. In certain embodiments, an "alkenylene" or "alkenylene chain" contains 2 to 12 carbon atoms. An alkenylene chain can be attached to one part of a molecule through one single bond and to a second part through one single bond. The points of attachment of the alkenylene chain to the rest of the molecule and to the second part can be through one carbon in the alkenylene chain or through any two carbons in the alkenylene chain. In certain embodiments, alkenylene contains 2 to 8 carbon atoms (e.g., C 2 ~C 8 In other embodiments, the alkenylene contains 2 to 5 carbon atoms (e.g., C 2 ~C5 In other embodiments, the alkenylene contains 2 to 4 carbon atoms (e.g., C 2 ~C 4 In other embodiments, the alkenylene contains 2 to 3 carbon atoms (e.g., C 2 ~C 3 In other embodiments, the alkenylene contains 5 to 8 carbon atoms (e.g., C 5 ~C 8 In other embodiments, the alkenylene contains 2 to 5 carbon atoms (e.g., C 2 ~C 5 In other embodiments, the alkenylene contains 3 to 5 carbon atoms (e.g., C 3 ~C 5 alkenylene).

[0043] An "alkynylene" or "alkynylene chain" refers to a linear (e.g., straight) or branched divalent hydrocarbon moiety. An "alkynylene" or "alkynylene chain" can link one part of a molecule to a second part. An "alkynylene" or "alkynylene chain" consists of only carbon and hydrogen (substitution of an alkynylene with one or more substituents containing atoms other than hydrogen, such as N, O, and S, can be specified). An "alkynylene" or "alkynylene chain" contains at least one carbon-carbon triple bond. In certain embodiments, an "alkynylene" or "alkynylene chain" contains 2 to 12 carbon atoms. An alkynylene chain can be attached to one part of a molecule through one single bond and to a second part through one single bond. The points of attachment of the alkynylene chain to the rest of the molecule and to the second part can be through one carbon in the alkynylene chain or through any two carbons in the alkynylene chain. In certain embodiments, alkynylene contains 2 to 8 carbon atoms (e.g., C 2 ~C 8 In other embodiments, the alkynylene contains 2 to 5 carbon atoms (e.g., C 2 ~C 5In other embodiments, the alkynylene contains 2 to 4 carbon atoms (e.g., C 2 ~C 4 In other embodiments, the alkynylene contains 2 to 3 carbon atoms (e.g., C 2 ~C 3 In other embodiments, the alkynylene contains two carbon atoms (e.g., C 2 In other embodiments, the alkynylene contains 5 to 8 carbon atoms (e.g., C 5 ~C 8 In other embodiments, the alkynylene contains 3 to 5 carbon atoms (e.g., C 3 ~C 5 alkynylene).

[0044] The term "carbocycle" as used herein refers to a saturated or unsaturated (e.g., aromatic or non-aromatic unsaturated) ring or ring system in which each atom of the ring is carbon. For example, the term "carbocycle" includes 3-12 membered monocyclic rings (e.g., 3-10 membered monocyclic rings) and 4-20 membered polycyclic ring systems (e.g., 5-15 membered spiro polycyclic ring systems, 5-15 membered bridged polycyclic ring systems, or 4-15 membered fused polycyclic ring systems). For example, carbocycles include 4-15 membered bicyclic rings (e.g., 5-15 membered spiro bicyclic rings, 5-15 membered bridged bicyclic ring systems, or 4-15 membered fused bicyclic ring systems). For example, carbocycles include tricyclic ring systems that may be bridged, fused, spiro, or combinations thereof. For example, carbocycles include tetracyclic ring systems that may be bridged, fused, spiro, or combinations thereof. For example, carbocycles include fused and bridged ring systems, fused and spiro ring systems, bridged and spiro ring systems, and fused and bridged ring systems that are also spiro. Each ring of a polycyclic carbocycle can be selected from saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings. In an exemplary embodiment, the aromatic ring of a polycyclic carbocycle, such as phenyl, can be fused to a saturated or unsaturated ring (e.g., cyclohexane, cyclopentane, cyclohexene, or phenyl). A polycyclic carbocycle can include any combination of saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings, as long as valences permit. For example, a polycyclic carbocycle can further include a spiro bicyclic ring, such as spiropentane. For example, polycyclic carbocycles include any combination of ring sizes such as a 2-2 spiro ring system (e.g., spiro[2.2]pentane), a 3-3 spiro ring system, a 4-4 spiro ring system, a 4-5 fused ring system (e.g., a bicyclo[4.5.0] fused ring system), a 5-5 fused ring system, a 5-6 fused ring system, a 6-6 fused ring system (e.g., naphthalene), a 5-7 fused ring system, a 6-7 fused ring system, a 5-8 fused ring system, and a 6-8 fused ring system.Exemplary carbocycles include cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, indanyl, naphthyl, trans-bicyclo[4.4.0]decane, cis-bicyclo[4.4.0]decane, spiro[3.4]octane, fluoranthene, and bicyclo[1.1.1]pentanyl.

[0045] The term "aryl" refers to an aromatic monocyclic or aromatic polycyclic hydrocarbon ring system that contains at least one cyclic delocalized (4n+2) π-electron system that follows the Huckel rule. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system contains only hydrogen and carbon atoms. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system contains 3-20 carbon atoms. In some embodiments, at least one of the rings of the polycyclic aromatic ring system is aromatic. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system contains a cyclic delocalized (4n+2) π-electron system that follows the Huckel rule. Ring systems from which the aryl group is derived include, but are not limited to, groups such as benzene, fluorene, indane, indene, anthracene, tetralin, and naphthalene. In some embodiments, the aryl substituent is positively or negatively charged. In some embodiments, the aryl substituent is neutral. In some embodiments, the aryl substituent is zwitterionic; alternatively or additionally, in some embodiments, the aryl substituent is uncharged. In some embodiments, the aryl substituent does not carry a charge. In some embodiments, the aryl substituent does not carry a net charge. In some embodiments, the aryl substituent does not carry a net charge and is not zwitterionic.

[0046] The term "cycloalkyl" refers to a saturated ring in which each atom of the ring is carbon. Cycloalkyls can include monocyclic and polycyclic rings such as 3-10 membered monocyclic rings, 5-12 membered bicyclic rings, 5-12 membered spiro bicyclic rings, and 5-12 membered bridged rings. In certain embodiments, cycloalkyls contain 3-10 carbon atoms. In other embodiments, cycloalkyls contain 3-7 carbon atoms. In other embodiments, cycloalkyls contain 5-7 carbon atoms. Cycloalkyls can be attached to the remainder of the molecule by a single bond. Examples of monocyclic cycloalkyls include, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of multicyclic cycloalkyls include, but are not limited to, adamantyl, spiropentane, norbornyl (i.e., bicyclo[2.2.1]heptanyl), decalinyl, 7,7 dimethylbicyclo[2.2.1]heptanyl, bicyclo[1.1.1]pentanyl, spiropentane, and the like.

[0047] The term "cycloalkenyl" refers to a saturated ring in which each atom of the ring is carbon and at least one double bond exists between two ring carbons. Cycloalkenyls can include monocyclic and polycyclic rings such as 3-10 membered monocyclic rings and 4-12 membered bicyclic rings (e.g., 5-12 membered bridged bicyclic rings, 4-12 membered fused bicyclic rings, and 5-12 membered spiro bicyclic rings). In other embodiments, cycloalkenyls contain 5-7 carbon atoms. Cycloalkenyls can be attached to the remainder of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, for example, cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl.

[0048] The term "halo", or alternatively "halogen" or "halide" means fluoro, chloro, bromo, or iodo. In some embodiments, halo is fluoro, chloro, or bromo.

[0049] The term "haloalkyl" refers to an alkyl, as defined above, substituted with one or more halogens, e.g., trifluoromethyl, dichloromethyl, bromomethyl, 2,2,2-trifluoroethyl, 1-chloromethyl-2-fluoroethyl, etc. In some embodiments, the alkyl portion of the haloalkyl is optionally further substituted as described herein.

[0050] The term "heterocycle" as used herein refers to a saturated or unsaturated (e.g., aromatic or non-aromatic unsaturated) ring or ring system in which one or more heteroatoms are members of the ring or ring system. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. For example, heterocycles include 3-12 membered monocyclic rings (e.g., 3-10 membered monocyclic rings) and 4-20 membered polycyclic ring systems (e.g., 4-15 membered fused polycyclic ring systems, 5-15 membered spiro polycyclic ring systems, and 5-15 membered bridged polycyclic ring systems). For example, heterocycles include 4-20 membered bicyclic ring systems (e.g., 4-15 membered fused bicyclic ring systems, 5-15 membered spiro bicyclic ring systems, and 5-15 membered bridged bicyclic ring systems). For example, heterocycles include tricyclic ring systems that can be bridged, fused, spiro, or combinations thereof. For example, heterocycles include tetracyclic ring systems that can be bridged, fused, spiro, or combinations thereof. For example, heterocycles include fused and bridged ring systems, fused and spiro ring systems, bridged and spiro ring systems, and fused and bridged ring systems that are also spiro. Each ring of a polycyclic heterocycle can be selected from saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings. Polycyclic heterocycles include any combination of saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings, as long as valence allows. In exemplary embodiments, aromatic rings, such as pyridyl or phenyl, can be fused to saturated or unsaturated rings, such as cyclohexane, cyclopentane, morpholine, piperidine, or cyclohexene, in the heterocycle, as long as at least one atom of the resulting fused ring system is a heteroatom. Polycyclic heterocycles include any combination of ring sizes such as 3-3 spiro, 4-5 fused ring systems, 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems, 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. Bicyclic heterocycles further include spiro bicyclic rings, such as 5-12 membered spiro bicycles, such as 2-oxa-6-azaspiro[3.3]heptane. In some embodiments, the heterocycle contains multiple heteroatoms. In some embodiments, the heterocycle contains nitrogen, oxygen,and sulfur. In some embodiments, the heterocycle comprises a plurality of atoms selected from nitrogen, oxygen, and sulfur. Non-limiting examples of heterocycles include pyridine, pyrrole, indole, carbazole, piperidine, oxazole, morpholine, thiophene, benzothiophene, furan, tetrahydrofuran, and pyran. Non-limiting examples of heterocycles include azepinyl, acridinyl, benzimidazolyl, benzoindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyran ... Lanonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl , indazolyl, indolyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyridinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl,Phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydroquinazolinyl, benzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (i.e., thienyl).

[0051] One or more nitrogen atoms, if present, are optionally quaternized. In some embodiments, the heterocyclic substituent is positively or negatively charged. In some embodiments, the heterocyclic substituent is neutral. In some embodiments, the heterocyclic substituent is zwitterionic, and alternatively or additionally, in some embodiments, the heterocyclic substituent is uncharged. In some embodiments, the heterocyclic substituent does not carry a charge. In some embodiments, the heterocyclic substituent does not carry a net charge. In some embodiments, the heterocyclic substituent does not carry a net charge and is not zwitterionic.

[0052] The term "heteroaryl" refers to a moiety derived from an aromatic monocyclic or polycyclic ring system in which one or more heteroatoms are members of the ring system and the ring system contains at least one cyclic delocalized cyclic (4n+2) π-electron system according to the Huckel rule. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. In some embodiments, a heteroaryl contains one or more heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, a heteroaryl contains multiple heteroatoms selected from nitrogen, oxygen, and sulfur. In certain embodiments, "heteroaryl" includes rings and ring systems containing 3-20 atoms. In some embodiments, "heteroaryl" includes rings and ring systems containing 2-17 carbon atoms and 1-6 heteroatoms selected from nitrogen, oxygen, and sulfur. As used herein, a heteroaryl moiety is a monocyclic or polycyclic (e.g., bicyclic, tricyclic, or tetracyclic) ring system, where at least one of the rings in the ring system is aromatic, i.e., contains a cyclic delocalized (4n+2) π-electron system according to the Huckel rule. Heteroaryl includes fused, bridged, and spiro ring systems. The heteroatom(s) of the heteroaryl moiety are optionally oxidized. One or more nitrogen atoms, if present, are optionally quaternized. Heteroaryl is bonded to the remainder of the molecule through any atom of the ring. Examples of heteroaryl include, but are not limited to, azepinyl, acridinyl, benzimidazolyl, benzoindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-Dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydro Cycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyridinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6, 6a,7,8,9,10,10a-Octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydrobenzo[h]quinazin ...oxalinyl, isoquinolinyl, tetrahydrobenzo[h]quinazinyl, quinoxalinyl, quinoxalinyl, isoquinolinyl, tetrahydrobenzo[h]quinazinyl, quinoxalinyl, quinoxalinyl, isoquinolinyl, tetrahydrobenzo[h]quinazinyl, quinoxalinyl, quinoxalinyl, isoquinolinyl, tetrahydrobenzo[h]quinazinyl, quinoxalinyl, quinoxalinyl, isoquinolinyl, tetrahydrobenzo[h]quinazinyl, quinoxal Hydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (i.e., thienyl). In some embodiments, the heteroaryl substituent is positively or negatively charged. In some embodiments, the heteroaryl substituent is neutral. In some embodiments, the heteroaryl substituent is zwitterionic, and alternatively or additionally, in some embodiments, the heteroaryl substituent is uncharged. In some embodiments, the heteroaryl substituent does not carry a charge. In some embodiments, the heteroaryl substituent does not carry a net charge. In some embodiments, the heteroaryl substituent does not carry a net charge and is not zwitterionic.

[0053] "Heterocycle" includes "heteroaryl" and "heterocycloalkyl." "Carbocycle" includes "aryl" and "cycloalkyl."

[0054] The term "heterocycloalkyl" refers to a saturated ring having carbon atoms and at least one heteroatom. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkyls can include monocyclic and polycyclic rings such as 3-10 membered monocyclic rings, 6-12 membered bicyclic rings, 5-12 membered spiro bicyclic rings, and 5-12 membered bridged rings. The heteroatoms of a heterocycloalkyl group are optionally oxidized. One or more nitrogen atoms, if present, are optionally quaternized. A heterocycloalkyl is attached to the remainder of the molecule through any atom of the heterocycloalkyl, e.g., any carbon or nitrogen atom of the heterocycloalkyl, if valence permits. Examples of heterocycloalkyl groups include, but are not limited to, dioxolanyl, thienyl[1,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 2-oxa-6-azaspiro[3.3]heptane, and 1,1-dioxo-thiomorpholinyl. In some embodiments, the heterocycloalkyl contains one heteroatom. In some embodiments, the heterocycloalkyl contains one heteroatom selected from N, O, and S. In some embodiments, the heterocycloalkyl contains multiple heteroatoms. In some embodiments, the heterocycloalkyl contains multiple heteroatoms selected from N, O, and S.

[0055] The term "heterocycloalkenyl" refers to an unsaturated ring having carbon atoms and at least one heteroatom, and at least one double bond exists between two ring carbons. Heterocycloalkenyl does not include heteroaryl rings. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkenyl can include monocyclic and polycyclic rings, such as 3-10 membered monocyclic rings, 6-12 membered bicyclic rings, and 5-12 membered bridged rings. In other embodiments, heterocycloalkenyl contains 5-7 ring atoms. Heterocycloalkenyl can be attached to the remainder of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, for example, pyrroline (dihydropyrrole), pyrazoline (dihydropyrazole), imidazoline (dihydroimidazole), triazoline (dihydrotriazole), dihydrofuran, dihydrothiophene, oxazoline (dihydrooxazole), isoxazoline (dihydroisoxazole), thiazoline (dihydrothiazole), isothiazolin (dihydroisothiazole), oxadiazoline (dihydrooxadiazole), thiadiazoline (dihydrothiadiazole), dihydropyridine, tetrahydropyridine, dihydropyridazine, tetrahydropyridazine, dihydropyrimidine, tetrahydropyrimidine, dihydropyrazine, tetrahydropyrazine, pyran, dihydropyran, thiopyran, dihydrothiopyran, dioxin, dihydrodioxin, oxazine, dihydrooxazine, thiazine, and dihydrothiazine.

[0056] The term "substituted" refers to a compound having one or more substitutable carbon or heteroatoms (e.g., NH or NH 2)。 It is understood that "substituted" or "substituted with" includes the implicit proviso that such substitution is in accordance with the allowed valencies of the substituted atom and the substituent, and further includes the proviso that the substitution results in a stable compound (e.g., a compound that does not rapidly undergo rearrangement, cyclization, elimination, etc.). In certain embodiments, substituted refers to a moiety having substituents replacing two hydrogen atoms on the same carbon atom (e.g., replacing the two hydrogen atoms on one carbon with an oxo, imino, oxime, hydrazone, or thioxo group). As used herein, the term "substituted" is intended to include all permissible substituents of organic compounds. In a broad aspect, the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and nonaromatic substituents of organic compounds. The permissible substituents can be one or more and the same or different for appropriate organic compounds.

[0057] In some embodiments, the substituents may include, for example, any of the following substituents described herein: halogen, hydroxy, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO 2 ), imino (=NH), oxime (=N-OH), hydrazino (=N-NH 2 ), -R b -OR a , -R b -OC(O)-R a , -R b -OC(O)-OR a , -R b -OC(O)-N(R a ) 2 , -R b -N(R a ) 2 , -R b -C(O)R a , -R b -C(O)OR a , -R b -C(O)N(R a ) 2 , -Rb -OR c -C(O)N(R a ) 2 , -R b -N(R a )C(O)OR a , -R b -N(R a )C(O)R a , -R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t OR a (where t is 1 or 2), and -R b -S(O) t N(R a ) 2 where t is 1 or 2; and alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl, any of which may be alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO 2 ), imino (=NH), oxime (=N-OH), hydrazine (=N-NH 2 ), -R b -OR a , -R b -OC(O)-R a , -R b -OC(O)-OR a , -R b -OC(O)-N(R a ) 2 , -R b -N(R a ) 2 , -R b -C(O)R a , -R b -C(O)ORa , -R b -C(O)N(R a ) 2 , -R b -OR c -C(O)N(R a ) 2 , -R b -N(R a )C(O)OR a , -R b -N(R a )C(O)R a , -R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t OR a (where t is 1 or 2) and -R b -S(O) t N(R a ) 2 where t is 1 or 2; a is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, where each R a is, if valence permits, alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO 2 ), imino (=NH), oxime (=N-OH), hydrazine (=N-NH 2 ), -R b -OR a , -R b -OC(O)-R a , -R b -OC(O)-OR a , -R b -OC(O)-N(R a ) 2 , -Rb -N(R a ) 2 , -R b -C(O)R a , -R b -C(O)OR a , -R b -C(O)N(R a ) 2 , -R b -OR c -C(O)N(R a ) 2 , -R b -N(R a )C(O)OR a , -R b -N(R a )C(O)R a , -R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t OR a (where t is 1 or 2) and -R b -S(O) t N(R a ) 2 where t is 1 or 2; and where each R b is independently selected from a direct bond or a straight or branched alkylene, alkenylene, or alkynylene chain, and each R c is a straight or branched alkylene, alkenylene, or alkynylene chain.

[0058] A double bond to an oxygen atom, such as an oxo group, is represented herein as both "=O" and "(O)". A double bond to a nitrogen atom is represented herein as both "=NR" and "(NR)". A double bond to a sulfur atom is represented herein as both "=S" and "(S)".

[0059] The phrases "parenteral administration" and "administered parenterally", as used herein, mean modes of administration other than enteral and local administration, usually by injection, including, but not limited to, intravenous, intramuscular, intraarterial, intrathecal, intraarticular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal and intrasternal injection and infusion.

[0060] The phrase "pharmacologically acceptable" is used herein to refer to compounds, materials, compositions, and / or dosage forms that are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without undue toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit / risk ratio.

[0061] The phrase "pharmacologically acceptable excipient" or "pharmacologically acceptable carrier" as used herein means a pharma- ceutically acceptable material, composition, or vehicle, such as a liquid or solid filler, diluent, excipient, solvent, or encapsulating material. Each carrier must be "acceptable" in the sense of being compatible with the other ingredients of the formulation and not harmful to the patient. Some examples of materials that can serve as pharma- ceutically acceptable carriers include: (1) sugars, such as lactose, glucose, and sucrose; (2) starches, such as corn starch and potato starch; (3) cellulose and its derivatives, such as sodium carboxymethylcellulose, ethylcellulose, and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) talc; (8) excipients, such as cocoa butter and suppository wax; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil, and the like. and soybean oil, (10) glycols, such as propylene glycol, (11) polyols, such as glycerin, sorbitol, mannitol, and polyethylene glycol, (12) esters, such as ethyl oleate and ethyl laurate, (13) agar, (14) buffers, such as magnesium hydroxide and aluminum hydroxide, (15) alginic acid, (16) pyrogen-free water, (17) isotonic saline, (18) Ringer's solution, (19) ethyl alcohol, (20) phosphate buffer solution, and (21) other non-toxic compatible substances used in pharmaceutical preparations.

[0062] The term "salt" or "pharmaceutically acceptable salt" refers to salts derived from various organic and inorganic counterions well known in the art. Pharmaceutically acceptable acid addition salts can be formed with inorganic and / or organic acids. Inorganic acids from which salts can be derived include, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. Organic acids from which salts can be derived include, for example, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. Pharmaceutically acceptable base addition salts can be formed with inorganic and / or organic bases. Inorganic bases from which salts can be derived include, for example, sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum, and the like. Organic bases from which salts can be derived include, for example, primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, basic ion exchange resins, and the like, specifically, for example, isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine. In some embodiments, the pharma-ceutically acceptable base addition salts are selected from ammonium, potassium, sodium, calcium, and magnesium salts.

[0063] As used herein, "treatment" or "treating" refers to an approach to obtain a beneficial or desired result with respect to a disease, disorder, or condition, including, but not limited to, therapeutic benefit and / or preventive benefit. Therapeutic benefit may include, for example, eradicating or alleviating the underlying disease being treated. Therapeutic benefit may also include, for example, eradicating or alleviating one or more of the physiological symptoms associated with the underlying disease, such that an improvement is observed in the subject, even though the subject may still be suffering from the underlying disease. In certain embodiments, for preventive benefit, the composition is administered to a subject at risk of developing the disease or reporting one or more of the physiological symptoms of the disease, even if a diagnosis of the specific disease has not been made. Treatment by administration of the compounds described herein does not require the involvement of a medical professional.

[0064] Chemical entities having carbon-carbon or carbon-nitrogen double bonds can exist in Z- or E-forms (or cis- or trans-forms). In addition, some chemical entities can exist in various tautomeric forms. Unless otherwise specified, the compounds described herein are intended to include all Z-, E- and tautomeric forms as well.

[0065] "Tautomer" refers to a molecule capable of proton shift from one atom of the molecule to another atom of the same molecule. The compounds presented herein exist as tautomers in certain embodiments. In environments where tautomerization is possible, a chemical equilibrium of tautomers exists. The exact ratio of tautomers depends on several factors, including physical conditions, temperature, solvent, and pH. Some examples of tautomeric equilibrium include: [ka] Examples include:

[0066] The compounds disclosed herein may, in some embodiments, be 2 H, 3 H, 11 C.13 C and / or 14 The compound is used in different enriched isotopic forms, enriched in C content. In a particular embodiment, the compound is deuterated at at least one position. Such deuterated forms can be made by the procedures described in U.S. Patent Nos. 5,846,514 and 6,334,997. As described in U.S. Patent Nos. 5,846,514 and 6,334,997, deuteration can improve metabolic stability and / or efficacy, and thus increase the duration of action of the drug.

[0067] Unless otherwise stated, the compounds described herein are intended to include compounds that differ only in the presence of one or more isotopically enriched atoms. For example, one or more protons have been replaced by one or more deuterium (deuterium) or tritium (tritium), or a combination thereof, or one or more 12 C atoms have one or more 13 C atom, one or more 14 Compounds having the present structures except for the replacement of a C atom, or combinations thereof, are within the scope of the disclosure.

[0068] The compounds of the present disclosure optionally contain unnatural proportions of atomic isotopes at one or more of the atoms that constitute such compounds. For example, the compounds may contain, for example, deuterium ( 2 H), tritium ( 3 H), iodine-125( 125 I) or carbon-14( 14 C), may be labeled with one or more isotopes. 2 H, 11 C. 13 C. 14 C. 15 C. 12 N, 13 N, 15 N, 16 N, 16 O. 17 O. 14 F,15 F, 16 F, 17 F, 18 F, 33 S, 34 S, 35 S, 36 S, 35 Cl, 37 Cl, 79 Br, 81 Br, and 125 All isotopic substitutions with I are contemplated. All isotopic variations of the compounds of the present invention, whether radioactive or not, are encompassed within the scope of the present invention.

[0069] In certain embodiments, the compounds disclosed herein comprise 1 Some or all of the H atoms 2 is replaced with an H atom. Methods for the synthesis of deuterium-containing compounds are known in the art and include, by way of non-limiting example only, the following synthetic methods:

[0070] Deuterium substituted compounds are synthesized using a variety of methods such as those described in Dean, Dennis C.; Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [In: Curr., Pharm. Des., 2000; 6(10)] 2000, 110pp, George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21, and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal. Chem., 1981, 64(1-2), 9-32.

[0071] Deuterated starting materials are readily available and are subject to the synthetic methods described herein to provide for the synthesis of deuterium-containing compounds. Many deuterium-containing reagents and components are commercially available from chemical suppliers such as MilliporeSigma.

[0072] The compounds of the present invention also include crystalline and amorphous forms of the compounds having the same type of activity, including, for example, polymorphs, pseudopolymorphs, solvates, hydrates, nonsolvated polymorphs (including anhydrates), conformational polymorphs, and amorphous forms of the compounds, and mixtures thereof, pharma- ceutically acceptable salts of these compounds, and active metabolites.

[0073] The present disclosure includes salts of the compounds described herein, particularly pharmaceutically acceptable salts.Compounds of the present disclosure that contain one or more sufficiently acidic functional groups, one or more sufficiently basic functional groups, or both one or more sufficiently acidic functional groups and one or more sufficiently basic functional groups to form salts (particularly pharmaceutically acceptable salts) can react with any of several inorganic or organic bases or inorganic or organic acids or combinations thereof to form salts.Alternatively, compounds that are inherently charged, such as compounds with quaternary nitrogen, can form salts with suitable counterions.

[0074] The compounds and salts described herein may, in some cases, exist as diastereomers, enantiomers, or other stereoisomeric forms. Unless otherwise specified, the structures disclosed herein are intended to include, either explicitly or implicitly, all diastereomeric (e.g., epimeric) and enantiomeric forms, as well as mixtures thereof. Separation of stereoisomers may be carried out by chromatography, or by forming diastereomers and separating them by recrystallization or chromatography, or any combination thereof. (Jean Jacques, Andre Collet, Samuel H. Wilen, "Enantiomers, Racemates and Resolutions", John Wiley And Sons, Inc., 1981, which is incorporated herein by reference for this disclosure). Stereoisomers may also be obtained by stereoselective synthesis.

[0075] The methods and compositions described herein include the use of amorphous and crystalline forms (also known as polymorphs). The compounds described herein may be in the form of pharmaceutically acceptable salts. Similarly, in some embodiments, the active metabolites of these compounds having the same type of activity are also included within the scope of the present disclosure. Furthermore, the compounds described herein may exist in unsolvated form and also in solvated form with pharmaceutically acceptable solvents such as water, ethanol, etc. The solvated forms of the compounds presented herein are also considered to be disclosed herein.

[0076] In certain embodiments, a compound or a salt of a compound can be a prodrug, for example, where a hydroxyl in a parent compound is presented as an ester or carbonate, or a carboxylic acid present in a parent compound is presented as an ester. The term "prodrug" is intended to encompass compounds that are converted to pharmaceuticals of the present disclosure under physiological conditions. One method for creating a prodrug is to include one or more selected moieties that undergo hydrolysis under physiological conditions to expose the desired molecule. In other embodiments, the prodrug is converted by the enzyme activity of the host animal, such as a specific target cell in the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids, and esters of phosphonic acids) are preferred prodrugs of the present disclosure.

[0077] Prodrug forms of the compounds described herein that are metabolized in vivo to produce the compounds as described herein are included within the scope of the claims. In some cases, some of the compounds described herein may be prodrugs for another derivative or active compound.

[0078] Prodrugs are often useful because they may be easier to administer than the parent drug in some circumstances. Prodrugs may, for example, be available by oral administration, whereas the parent is not bioavailable by oral administration. Prodrugs may help to enhance the cell permeability of the compound relative to the parent drug. Prodrugs may also improve the solubility in pharmaceutical compositions over the parent drug. Prodrugs may be designed as reversible drug derivatives to enhance drug transport to site-specific tissues or to be used as modifiers to increase drug retention inside cells.

[0079] In some embodiments, the prodrug design increases the lipophilicity of the pharmaceutical agent, hi some embodiments, the prodrug design increases the effective water solubility. For example, Fedorak et al., Am.J.Physiol.,269:G210-218(1995), McLoed et al.,Gastroenterol,106:405-413(1994), Hochhaus et al.,Biomed.Chrom.,6:283-286(1992), J.Larsen and H.Bundgaard, Int.J.Pharmaceutics,37,87(1987), J.Larsen et al.,Int.J.Pharmaceutics,47,103(1988), Sinkula et al.,J.Pharm.Sci.,64:181-210(1975), T.Higuchi and V.Stella,Pro-drugs as Novel Delivery Systems,Vol.14 of the ACSSymposium Series, and Edward See B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987 (all such disclosures are incorporated herein by reference). According to another embodiment, the present disclosure provides a method for producing the compounds defined above. The compounds may be synthesized using conventional techniques. Advantageously, these compounds are conveniently synthesized from readily available starting materials.

[0080] Synthetic chemistry transformations and methodologies useful for the synthesis of the compounds described herein are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations (1989), T. W. Greene and P. G. Muts, Protective Groups in Organic Synthesis, 2d. Ed. (1991), L. Fieser and M. Fieser, Fieser and Fieser's Reagents for Organic Synthesis (1994), and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis (1995).

[0081] compound Below is a discussion of compounds and salts thereof that may be used in the methods of the disclosure.

[0082] compound The following is a discussion of compounds and salts thereof that may be used in the methods of the present disclosure. In certain embodiments, the compounds and salts are described by formula (Ia), (Ib), (II), (III), (IV), (V), (VI), (VII), or (VIII).

[0083] In one aspect, the present specification provides a compound of formula (Ia) or (Ib): [ka] or a salt thereof, wherein Y 1 is N or CR 4 and R 1 teeth, hydrogen, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 )2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and C 3~10Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from R 2 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and -C(O)NR 7 R 8 is selected from Each R 3 is halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 , -CN, and halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 4 is hydrogen, halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 , -CN, and halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, Each R 5 teeth, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2, -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), and -CN, are independently selected from Each R 6 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 7 represents hydrogen, as well as halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, R 8 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 )2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from [p is 0, 1, or 2].

[0084] In certain embodiments, the compound or salt of formula (Ia) is [ka] or a salt thereof.

[0085] In certain embodiments, the compound or salt of formula (Ib) is [ka] or a salt thereof.

[0086] In certain embodiments, for compounds or salts of formula (Ia) or (Ib), Y is N.

[0087] In certain embodiments, for compounds or salts of formula (Ia) or (Ib), Y is CR 4 It is.

[0088] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 teeth, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6)C(O)OR 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from.

[0089] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 teeth, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 )2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from.

[0090] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 teeth, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6, -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , and -CN, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0091] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6, -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are each substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 )2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 are phenyl, pyridinyl, and morpholinyl (which are halogen, -CN, -OH, -SH, -NO, respectively). 2 , -NH 2 , =O, =S, -OC1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In some embodiments, R is selected from the group consisting of aryl, arylalkyl, arylsulfonyl, arylalkyl, and arylsulfuryl. 1 are phenyl, pyridinyl, and morpholinyl (which are methyl, ethyl, and -CF 3 , -CHF 2 , -CH 2 F, -CH 2 CHF 2 , -CH 2 CF 3 , and -CH 2 CH 2 and F. In certain embodiments, R 1 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from phenyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 1 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 1 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0092] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 1 teeth, [ka] In some embodiments, R 1 teeth, [ka] is selected from.

[0093] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and -C(O)NR 7 R 8 is selected from.

[0094] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and -C(O)NR 7 R 8 is selected from.

[0095] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and -C(O)NR 7 R 8 is selected from.

[0096] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R is selected from the group consisting of pyridinyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 2 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 2 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0097] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 teeth, [ka] is selected from.

[0098] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 2 is C(O)NR 7 R 8 It is.

[0099] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 7 represents hydrogen, as well as the halogens -OH, -SH, and -NH 2 , -NO 2 , -CN, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, R 7 represents hydrogen, as well as the halogens -OH, -SH, and -NH 2 , -NO 2 C optionally substituted with one or more substituents independently selected from -CN, -OMe, and -OMe; 1~6 In certain embodiments, R 7is hydrogen and C 1~6 In certain embodiments, R 7 is hydrogen. In some embodiments, R 7 is selected from methyl, ethyl, n-propyl and isopropyl.

[0100] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 8 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from.

[0101] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 8 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl; C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0102] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 8 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 In certain embodiments, R 8 is C 1~6 In certain embodiments, R 8 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 8 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl; R 7 is hydrogen. In some embodiments, R 8 is selected from ethyl. 8 is selected from ethyl, R 7 is hydrogen.

[0103] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), each R 3 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6In certain embodiments, each R 3 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, each R 3 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 In certain embodiments, each R 3 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, each R 3 is C 1~6 In certain embodiments, R 3 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0104] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), p is 0. In certain embodiments, p is 1. In certain embodiments, p is 2.

[0105] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 4 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 4 represents hydrogen, as well as the halogens -CN, -OH, -SH and -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, for a compound or salt of formula (Ia) or (Ib), R 4 is hydrogen. In certain embodiments, R 4 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0106] In certain embodiments, for a compound or salt of formula (Ia) or (Ib), each R 5 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 5 is selected from methyl, ethyl, and propyl.

[0107] In certain embodiments, each R 6 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 6 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 6 is hydrogen.

[0108] In one aspect, the present specification provides a compound of formula (Ia) or (Ib): [ka] or a salt thereof, wherein Y 1 is N or CR 4 and R 1 teeth, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , =O, =S, =N(R 6 ), -CN, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 C optionally substituted with one or more substituents independently selected from 1~6Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , -CN,C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from R 2 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R6 )C(O)R 6 , -OC(O)N(R 6 ) 2 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 each being replaced as necessary), and -C(O)NR 7 R 8 is selected from Each R 3 is halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 , -CN, and halogens, -OR 6 , -SR 6, -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 4 is hydrogen, halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 , -CN, and halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, Each R 5 teeth, Halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 6 , -SR 6, -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -N(R 6 )C(O)OR 6 , -C(O)OR 6 , -OC(O)R 6 , -S(O)R 6 , -S(O) 2 R 6 , -NO 2 , =O, =S, =N(R 6 ), and -CN, are independently selected from Each R 6 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 7 represents hydrogen, as well as halogens, -OR 6 , -SR 6 , -N(R 6 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, R 8 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 6 , -SR 6 , -N(R 6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -OC(O)N(R 6 ) 2 , -C(O)OR 6 , -OC(O)R 6 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 6 , -SR 6 , -N(R6 ) 2 , -C(O)R 6 , -C(O)N(R 6 ) 2 , -N(R 6 )C(O)R 6 , -N(R 6 )C(O)N(R 6 ) 2 , -OC(O)N(R 6 ) 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from [p is 0, 1, or 2].

[0109] In one aspect, the present specification provides a compound of formula (Ia) or (Ib): [ka] or a salt thereof, wherein Y 1 is N, R 1 teeth, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from R 2 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 alkyl), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from R 4 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 alkyl, Each R 5 teeth, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 Alkyl, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 and optionally substituted with one or more substituents independently selected from alkyl. are independently selected from Each R 6 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2, -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from p is 0].

[0110] In one aspect, the present specification provides a compound of formula (Ia) or (Ib): [ka] or a salt thereof, wherein Y 1 is N, R 1 teeth, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from R 2 -C(O)NR 7 R 8 and R 4 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 alkyl, Each R 5 teeth, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 Alkyl, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 and optionally substituted with one or more substituents independently selected from alkyl. are independently selected from Each R 6 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 7 represents hydrogen, as well as the halogens -OH, -SH, and -NH 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, R 8 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 5 (each replaced as necessary) is selected from p is 0].

[0111] In certain embodiments, the compound or salt of formula (Ia) or (Ib) is [ka] [ka] and a salt of any one of these.

[0112] In certain embodiments, the compound or salt of formula (Ia) or (Ib) is [ka] and a salt of any one of these.

[0113] In certain embodiments, the compound or salt of formula (Ia) or (Ib) is [ka] and a salt of any one of these.

[0114] In certain embodiments, the compound or salt of formula (Ia) or (Ib) is [ka] [ka] and a salt of any one of these.

[0115] In one aspect, the present specification provides a compound of formula (II): [ka] or a salt thereof, wherein Y 11 is N or CR 14 and R 11 teeth, hydrogen, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from R 12 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from Each R 13 is halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 14 is hydrogen, halogen, -OR 16 , -SR 16 , -N(R 16 )2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 15 teeth, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 )2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, are independently selected from Each R 16 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R17 represents hydrogen, as well as halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2].

[0116] In certain embodiments, the compound or salt of formula (II) is [ka] isn't it.

[0117] In certain embodiments, for compounds or salts of formula (II), Y is N.

[0118] In certain embodiments, for the compounds or salts of formula (II), Y is CR 14 It is.

[0119] In certain embodiments, for a compound or salt of formula (II), R 11 teeth, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16)C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from.

[0120] In certain embodiments, for a compound or salt of formula (II), R 11 teeth, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16)C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -NO 2 , and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from.

[0121] In certain embodiments, for a compound or salt of formula (II), R 11 teeth, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16, -OC(O)R 16 , -NO 2 , and -CN, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0122] In certain embodiments, for a compound or salt of formula (II), R 11 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 and each optionally substituted).

[0123] In certain embodiments, for a compound or salt of formula (II), R 11 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are each substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 and each optionally substituted).

[0124] In certain embodiments, for a compound or salt of formula (II), R 11 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl.

[0125] In certain embodiments, for a compound or salt of formula (II), R 11 are phenyl and pyridinyl (which are halogen, -CN, -OH, -SH, -NO, respectively). 2 , -NH 2 , -OC 1~6Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 11 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In some embodiments, R is selected from phenyl optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 12 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 12 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0126] In certain embodiments, for a compound or salt of formula (II), R 11 teeth, [ka] is selected from.

[0127] In certain embodiments, for a compound or salt of formula (II), R 11 is halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 In certain embodiments, for a compound or salt of formula (II), R 11 is halogen, -OR 16 , -SR 16, -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 In certain embodiments, for a compound or salt of formula (II), R 11 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10In certain embodiments, for a compound or salt of formula (II), R 11 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and is selected from carbocycle, 3- to 10-membered heterocycle, and pyridinyl optionally substituted with one or more substituents independently selected from haloalkyl.

[0128] In certain embodiments, for a compound or salt of formula (II), R 11 teeth, [ka] is selected from.

[0129] In certain embodiments, for a compound or salt of formula (II), R 12 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -NO 2 , -CN,C 3~10Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from.

[0130] In certain embodiments, for a compound or salt of formula (II), R 12 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl; C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0131] In certain embodiments, for a compound or salt of formula (II), R 12 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 12 is C 1~6 In certain embodiments, R 12 is selected from methyl, ethyl, and propyl. 12is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0132] In certain embodiments, for a compound or salt of formula (II), each R 13 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, each R 13 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, each R 13 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, each R 13 is C 1~6 In certain embodiments, R 13 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0133] In certain embodiments, for a compound or salt of formula (II), p is 0. In certain embodiments, p is 1. In certain embodiments, p is 2.

[0134] In certain embodiments, for a compound or salt of formula (II), R 14 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, for a compound or salt of formula (II), R 14 represents hydrogen, as well as the halogens -CN, -OH, -SH and -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, R 14 is hydrogen. In certain embodiments, R 14 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0135] In certain embodiments, for a compound or salt of formula (II), each R 15 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 15 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0136] In certain embodiments, for a compound or salt of formula (II), each R 16 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 16 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 16 is hydrogen.

[0137] In one aspect, the present specification provides a compound of formula (II): [ka] or a salt thereof, Y 11 is N or CR 14 and R 11 teeth, hydrogen, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from R 12 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16)C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from Each R 13 is halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 14 is hydrogen, halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 15 teeth, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, are independently selected from Each R 16 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 17 represents hydrogen, as well as halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2; Here, the compound is [ka] isn't it.

[0138] In one aspect, the present specification provides a compound of formula (II): [ka] or a salt thereof, wherein Y 11 is N or CR 14 and R 11 teeth, hydrogen, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -C(O)OR 16 , -OC(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each of which is optionally substituted with one or more substituents independently selected from is selected from R 12 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 16 , -SR16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO2 , =O, =S, =N(R 16 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 15 (each replaced as necessary) is selected from Each R 13 is halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 14 is hydrogen, halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 , -CN, and halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 15 teeth, Halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16)C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 16 , -SR 16 , -N(R 16 ) 2 , -C(O)R 16 , -C(O)N(R 16 ) 2 , -N(R 16 )C(O)R 16 , -N(R 16 )C(O)N(R 16 ) 2 , -OC(O)N(R 16 ) 2 , -N(R 16 )C(O)OR 16 , -C(O)OR 16 , -OC(O)R 16 , -S(O)R 16 , -S(O) 2 R 16 , -NO 2 , =O, =S, =N(R 16 ), and -CN, are independently selected from Each R 16 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 17 represents hydrogen, as well as halogens, -OR 16 , -SR 16 , -N(R 16 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2].

[0139] In one aspect, the present specification provides a compound of formula (II): [ka] or a salt thereof, wherein Y 11 is N, R 11 teeth, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings may be substituted with one or more halogens, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 C optionally substituted with one or more substituents independently selected from 1~6 Alkyl, and Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings may be substituted with one or more halogens, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6a 3- to 10-membered heterocycle optionally substituted with one or more substituents independently selected from is selected from R 12 teeth, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings may be substituted with one or more halogens, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 C optionally substituted with one or more substituents independently selected from 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl)C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings may be substituted with one or more halogens, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 alkyl), each of which is optionally substituted. is selected from R 17 represents hydrogen, as well as the halogens -OH, -SH 6 , -NH 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0].

[0140] In certain embodiments, the compound or salt of formula (II) is [ka] [ka] and a salt of any one of these.

[0141] In certain embodiments, the compound or salt of formula (II) is [ka] and a salt of any one of these.

[0142] In certain embodiments, the compound or salt of formula (II) is [ka] and a salt of any one of these.

[0143] In one aspect, the present specification provides a compound of formula (III): [ka] or a salt thereof, wherein R 21 teeth, hydrogen, Halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , and -CN, C 2~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), -CN, C 3~10Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 (each replaced as necessary) is selected from R 22 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R26 , -NO 2 , =O, =S, =N(R 26 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 (each replaced as necessary) is selected from Each R 23 is halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -NO 2 , -CN, and halogens, -OR 26 , -SR 26 , -N(R 26 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 25 teeth, Halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2, =O, =S, =N(R 26 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), and -CN, are independently selected from Each R 26 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from [p is 0, 1, or 2].

[0144] In certain embodiments, for a compound or salt of formula (III), R 21 teeth, Halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , and -CN, C 2~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 26 , -SR 26, -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2, =O, =S, =N(R 26 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 (each replaced as necessary) is selected from.

[0145] In certain embodiments, for a compound or salt of formula (III), R 21 teeth, Halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -NO 2 , and -CN, C 2~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -NO 2 , -CN,C 3~10Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -NO 2 , and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 (each replaced as necessary) is selected from.

[0146] In certain embodiments, for a compound or salt of formula (III), R 21 teeth, Halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -NO 2 , and -CN, Halogen, -CN, -OH, -SH -NO 2 , -NH2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 2~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0147] In certain embodiments, for a compound or salt of formula (III), R 21 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 In certain embodiments, R 21 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are each substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), -CN, C 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 In certain embodiments, R 21 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 21 are phenyl and pyridinyl (which are halogen, -CN, -OH, -SH, -NO, respectively). 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 21are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from phenyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 21 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 21 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0148] In certain embodiments, for a compound or salt of formula (III), R 21 teeth, [ka] is selected from.

[0149] In certain embodiments, for a compound or salt of formula (III), R 22 teeth, C 1~6 Alkyl, C 2~6Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 (each replaced as necessary) is selected from.

[0150] In certain embodiments, for a compound or salt of formula (III), R 22 is C 3~10Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -N(R 26 )C(O)N(R 26 ) 2 , -OC(O)N(R 26 ) 2 , -N(R 26 )C(O)OR 26 , -C(O)OR 26 , -OC(O)R 26 , -S(O)R 26 , -S(O) 2 R 26 , -NO 2 , =O, =S, =N(R 26 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 In certain embodiments, R 22 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 26 , -SR 26 , -N(R 26 ) 2 , -C(O)R 26 , -C(O)N(R 26 ) 2 , -N(R 26 )C(O)R 26 , -C(O)OR 26 , -OC(O)R 26 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 25 In certain embodiments, R 22 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 22 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridinyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 22 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0151] In certain embodiments, for a compound or salt of formula (III), R 22 are 3-10 membered heterocycles (these are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from a carbocycle, a 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3-10 membered heterocycles are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 In certain embodiments, R is selected from the group consisting of aryl, aryl, aryl, and alkyl. 22 are 5- to 9-membered heterocycles (these are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from a carbocycle, a 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3-10 membered heterocycles are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C1~6 Alkyl) 2 , -NH(C 1~6 In certain embodiments, R is selected from the group consisting of aryl, aryl, aryl, and alkyl. 22 is a halogen, C 1~6 Alkyl, phenyl, and pyridyl (where C 1~6 Alkyl, phenyl, and pyridyl are not affected by halogens, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 In certain embodiments, R is selected from the group consisting of 5-membered heterocycles, optionally substituted with one or more substituents independently selected from alkyl, aryl, aryls, and 5-membered heterocycles, optionally substituted with one or more substituents independently selected from alkyl. 22 is a halogen, C 1~6 Alkyl, phenyl, and pyridyl (where C 1~6 Alkyl, phenyl, and pyridyl are selected from 5-membered heterocycles optionally substituted with one or more substituents independently selected from halogen.

[0152] In certain embodiments, for a compound or salt of formula (III), R 22 teeth, [ka] is selected from.

[0153] In certain embodiments, for a compound or salt of formula (III), each R 23 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, each R 23 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, each R 23 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, each R 23 is C 1~6 In certain embodiments, R 23 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0154] In certain embodiments, for a compound or salt of formula (III), p is 0. In certain embodiments, p is 1. In certain embodiments, p is 2.

[0155] In certain embodiments, for a compound or salt of formula (III), each R 25 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 25 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. In certain embodiments, for a compound or salt of formula (II), each R 26 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, each R 26 represents hydrogen, halogen, and halogens, -CN, -OH, -SH, -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 26 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 26 is hydrogen.

[0156] In certain embodiments, for a compound or salt of formula (III), the compound is [ka] and a salt of any one of these.

[0157] In certain embodiments, for a compound or salt of formula (III), the compound is [ka] and a salt of any one of these.

[0158] In certain embodiments, for a compound or salt of formula (III), the compound is [ka] [ka] and a salt of any one of these.

[0159] In one aspect, the present specification provides a compound of formula (IV): [ka] or a salt thereof, wherein R 31 teeth, hydrogen, Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -S(O)R 36 , -S(O)2 R 36 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 )2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 (each replaced as necessary) is selected from R 32 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , -CN,C 3~10Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each being replaced as necessary), and Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), and -CN, C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each of which is optionally substituted with one or more substituents independently selected from is selected from Each R 33 is halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2 , -CN, and halogens, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 34 is hydrogen, halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2 , -CN, and halogens, -OR 36 , -SR 36 , -N(R 36 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 35 teeth, Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), and -CN, are independently selected from Each R 36 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from [p is 0, 1, or 2].

[0160] In certain embodiments, for a compound or salt of formula (IV), R 31 teeth, Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -N(R 36)C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each being replaced as necessary), and 3-10 membered heterocycles (each of which is a halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 (each replaced as necessary) is selected from.

[0161] In certain embodiments, for a compound or salt of formula (IV), R 31 teeth, Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 36 , -SR 36 , -N(R 36 )2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -NO 2 , and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 (each replaced as necessary) is selected from.

[0162] In certain embodiments, for a compound or salt of formula (IV), R 31 teeth, Halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -NO 2 , and -CN, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0163] In certain embodiments, for a compound or salt of formula (IV), R 31 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 In certain embodiments, for a compound or salt of formula (IV), R 31 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are each substituted with halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -N(R 36 )C(O)N(R 36 ) 2 , -OC(O)N(R 36 ) 2 , -N(R 36 )C(O)OR 36 , -C(O)OR 36 , -OC(O)R 36 , -S(O)R 36 , -S(O) 2 R 36 , -NO 2 , =O, =S, =N(R 36 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 In certain embodiments, for a compound or salt of formula (IV), R 31 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, for a compound or salt of formula (IV), R 31 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridinyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 31 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from phenyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 31 are halogens, -CN, -OH, -SH -NO 2 , -NH2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 31 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0164] In certain embodiments, for a compound or salt of formula (IV), R 31 teeth, [ka] is selected from.

[0165] In certain embodiments, for a compound or salt of formula (IV), R 32 is halogen, -OR 36 , -SR 36 , -N(R 36 ) 2 , -C(O)R 36 , -C(O)N(R 36 ) 2 , -N(R 36 )C(O)R 36 , -C(O)OR 36 , -OC(O)R 36 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35In certain embodiments, for a compound or salt of formula (IV), R 32 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, for a compound or salt of formula (IV), R 32 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridinyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 32 is pyridyl optionally substituted with one or more halogens.

[0166] In certain embodiments, for a compound or salt of formula (IV), R 32 teeth, [ka] is selected from.

[0167] In certain embodiments, for a compound or salt of formula (IV), each R 33 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, for a compound or salt of formula (IV), each R 33 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, each R 33 is C 1~6 In certain embodiments, R 33 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0168] In certain embodiments, for a compound or salt of formula (IV), p is 0. In certain embodiments, p is 1. In certain embodiments, p is 2.

[0169] In certain embodiments, for a compound or salt of formula (IV), R 34 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, R 34 represents hydrogen, as well as the halogens -CN, -OH, -SH and -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, R 34 is hydrogen. In certain embodiments, R 34 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0170] In certain embodiments, for a compound or salt of formula (IV), each R 35 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 35 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0171] In certain embodiments, for a compound or salt of formula (IV), each R 36 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 36 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 36 is hydrogen.

[0172] In some embodiments, each R 36 represents hydrogen, halogen, and halogens, -CN, -OH, -SH, -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 is selected from alkyl.

[0173] In one aspect, the present specification provides a compound of formula (IV): [ka] or a salt thereof, wherein R 31 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R35 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 (each replaced as necessary) is selected from R 32 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each being replaced as necessary), and Halogen, -CN, -OH, -SH -NO 2 , -NH 2, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 35 each of which is optionally substituted with one or more substituents independently selected from is selected from Each R 33 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6 C optionally substituted with one or more substituents independently selected from 1~6 independently selected from alkyl, R 34 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6 C optionally substituted with one or more substituents independently selected from 1~6 independently selected from alkyl, Each R 35 teeth, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6 alkyl), and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6 alkyl) are independently selected from Each R 36 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from p is 0, 1, or 2].

[0174] In one aspect, the present specification provides a compound of formula (IV): [ka] or a salt thereof, wherein R 31 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle; C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from a carbocycle, a 3- to 10-membered heterocycle, is selected from R 32 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle; Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 3~10 A 3- to 10-membered heterocycle optionally substituted with one or more substituents independently selected from a carbocycle and a 3- to 10-membered heterocycle. is selected from R 34 is hydrogen, p is 0].

[0175] In certain embodiments, for a compound or salt of formula (IV), the compound is [ka] and salts thereof.

[0176] In one aspect, the present specification provides a compound of formula (V): [ka] or a salt thereof, wherein X 41 is O or S, R 41 teeth, hydrogen, Halogen, -OR 46 , -SR 46 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46)C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from R 42 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and -C(O)NR 47 R 48 is selected from Each R 43 is halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 , -CN, and halogens, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 45 teeth, Halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, are independently selected from Each R 46 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 47 represents hydrogen, as well as halogens, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, R 48 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 3~10and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from [p is 0, 1, or 2].

[0177] In certain embodiments, for a compound or salt of formula (V), the compound is not: [ka]

[0178] In certain embodiments, for a compound or salt of formula (V), X 41 is O. In certain embodiments, X 41 is S.

[0179] In certain embodiments, for a compound or salt of formula (V), R 41 teeth, Halogen, -OR 46 , -SR 46 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from.

[0180] In certain embodiments, for a compound or salt of formula (V), R 41 teeth, Halogen, -OR 46 , -SR 46 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , -CN,C 3~10Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from.

[0181] In certain embodiments, for a compound or salt of formula (V), R 41 teeth, Halogen, -OR 46 , -SR 46 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , and -CN, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0182] In certain embodiments, for a compound or salt of formula (V), R 41 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46)C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 In certain embodiments, for a compound or salt of formula (V), R 41 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are each substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 In certain embodiments, for a compound or salt of formula (V), R 41 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl.

[0183] In certain embodiments, for a compound or salt of formula (V), R 41 are phenyl and pyridinyl (which are halogen, -CN, -OH, -SH, -NO, respectively). 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 41 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from phenyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 41 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 41 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens. In certain embodiments, for a compound or salt of formula (V), R 41 teeth, [ka] In certain embodiments, for a compound or salt of formula (V), R 41 teeth, [ka] In some embodiments, R 41 teeth, [ka] is selected from.

[0184] In certain embodiments, for a compound or salt of formula (V), R 42 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and -C(O)NR 47 R 48 is selected from.

[0185] In certain embodiments, for a compound or salt of formula (V), R 42 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and -C(O)NR47 R 48 is selected from.

[0186] In certain embodiments, for a compound or salt of formula (V), R 42 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from.

[0187] In certain embodiments, for a compound or salt of formula (V), R 42 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 )2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 In certain embodiments, for a compound or salt of formula (V), R 42 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, for a compound or salt of formula (V), R 42 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 3~10 In certain embodiments, R is selected from pyridinyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 42 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0188] In certain embodiments, for a compound or salt of formula (V), R 42 teeth, [ka] is selected from.

[0189] In certain embodiments, for a compound or salt of formula (V), R 42 -C(O)NR 47 R 48 It is.

[0190] In certain embodiments, for a compound or salt of formula (V), R 47 is hydrogen and C 1~6 In certain embodiments, R 47 is selected from hydrogen.

[0191] In certain embodiments, for a compound or salt of formula (V), R 48 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , -CN,C3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from.

[0192] In certain embodiments, for a compound or salt of formula (V), R 48 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl; C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0193] In certain embodiments, for a compound or salt of formula (V), R 48 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 48 is C 1~6 In certain embodiments, R 48 is C 1~6 alkyl; R 47 is hydrogen. In certain embodiments, R 48is selected from methyl, ethyl, and propyl. In certain embodiments, R 48 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 48 is selected from ethyl. In certain embodiments, R 48 is selected from ethyl, R 47 is hydrogen.

[0194] In certain embodiments, for a compound or salt of formula (V), each R 43 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, for a compound or salt of formula (V), each R 43 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, for a compound or salt of formula (V), each R 43 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, each R 43 is C 1~6 In certain embodiments, R 43 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0195] In certain embodiments, for a compound or salt of formula (V), p is 0. In certain embodiments, p is 1. In certain embodiments, p is 2.

[0196] In certain embodiments, for a compound or salt of formula (V), each R 45 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 45 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0197] In certain embodiments, for a compound or salt of formula (V), each R 46 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2, and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 46 is selected from methyl, ethyl, and propyl.

[0198] In certain embodiments, for a compound or salt of formula (V), each R 46 represents hydrogen, halogen, and halogens, -CN, -OH, -SH, -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 46 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 46 is hydrogen.

[0199] In one aspect, the present specification provides a compound of formula (V): [ka] or a salt thereof, X 41 is O or S, R 41 teeth, hydrogen, Halogen, -OR 46 , -SR 46 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R46 , -S(O) 2 R 46 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2, -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from R 42 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and -C(O)NR 47 R 48 is selected from Each R 43 is halogen, -OR 46 , -SR 46 , -N(R 46 ) 2, -NO 2 , -CN, and halogens, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 45 teeth, Halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, are independently selected from Each R 46 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 47 represents hydrogen, as well as halogens, -OR46 , -SR 46 , -N(R 46 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, R 48 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 where appropriate, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 )2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from p is 0, 1, or 2; Here, the compound is not: [ka]

[0200] In one aspect, the present specification provides a compound of formula (V): [ka] or a salt thereof, wherein X 41 is O or S, R 41 teeth, hydrogen, Halogen, -OR 46 , -SR 46 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -C(O)OR 46 , -OC(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from R 42 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46)C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 45 (each replaced as necessary) is selected from Each R 43 is halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 , -CN, and halogens, -OR 46 , -SR 46 , -N(R 46 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 45 teeth, Halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R 46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 46 , -SR 46 , -N(R 46 ) 2 , -C(O)R 46 , -C(O)N(R46 ) 2 , -N(R 46 )C(O)R 46 , -N(R 46 )C(O)N(R 46 ) 2 , -OC(O)N(R 46 ) 2 , -N(R 46 )C(O)OR 46 , -C(O)OR 46 , -OC(O)R 46 , -S(O)R 46 , -S(O) 2 R 46 , -NO 2 , =O, =S, =N(R 46 ), and -CN, are independently selected from Each R 46 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from [p is 0, 1, or 2].

[0201] In one aspect, the present specification provides a compound of formula (V): [ka] or a salt thereof, wherein X 41 is O or S, R 41 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocyclic rings and 3-10 membered heterocyclic rings are not affected by halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 each optionally substituted with one or more substituents independently selected from alkyl, is selected from R 42 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocyclic rings and 3- to 10-membered heterocyclic rings are not affected by halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 each optionally substituted with one or more substituents independently selected from alkyl, is selected from p is 0]. In certain embodiments, for a compound or salt of formula (V), the compound is [ka] [ka] [ka] and a salt of any one of these.

[0202] In certain embodiments, for a compound or salt of formula (V), the compound is [ka] and a salt of any one of these.

[0203] In certain embodiments, for a compound or salt of formula (V), the compound is [ka] and a salt of any one of these.

[0204] In certain embodiments, for a compound or salt of formula (V), the compound is [ka] [ka] and a salt of any one of these.

[0205] In one aspect, the present specification provides a compound of formula (VI): [ka] or a salt thereof, wherein X 51 is selected from O and S; R 51 teeth, hydrogen, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56)C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from R 52 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56, -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from Each R 53 is halogen, -OR 56 , -SR 56 , -N(R 56) 2 , -NO 2 , -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 54 is hydrogen, halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings are preferably substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 -, and -CN, each optionally substituted with one or more substituents independently selected from Each R 55 teeth, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56, -NO 2 , =O, =S, =N(R 56 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, are independently selected from Each R 56 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 57 represents hydrogen, as well as halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2].

[0206] In certain embodiments, for a compound or salt of formula (VI), the compound is [ka] isn't it.

[0207] In certain embodiments, for a compound or salt of formula (VI), X 51 is O. In certain embodiments, X 51 is S.

[0208] In certain embodiments, for a compound or salt of formula (VI), R 51 teeth, Halogen, -OR 56 , -SR 56 , -N(R56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from.

[0209] In certain embodiments, for a compound or salt of formula (VI), R 51 teeth, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -NO 2 , and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from.

[0210] In certain embodiments, for a compound or salt of formula (VI), R 51 teeth, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -NO 2 , and -CN, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0211] In certain embodiments, for a compound or salt of formula (VI), R 51 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 In certain embodiments, for a compound or salt of formula (VI), R 51 is C 5~6Carbocyclic and 5- to 6-membered heterocyclic rings (which are each substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 In certain embodiments, for a compound or salt of formula (VI), R 51 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 carbocycle, 3- to 10-membered heterocycle, and haloalkyl. In certain embodiments, for a compound or salt of formula (VI), R 51 are phenyl and pyridinyl (which are halogen, -CN, -OH, -SH, -NO, respectively). 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 51 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from phenyl optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 51 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 In certain embodiments, R is selected from pyridyl, optionally substituted with one or more substituents independently selected from carbocycle, 3-10 membered heterocycle, and haloalkyl. 51 is selected from phenyl and pyridyl, each of which is optionally substituted with one or more halogens.

[0212] In certain embodiments, for a compound or salt of formula (VI), R 51 teeth, [ka] is selected from.

[0213] In certain embodiments, for a compound or salt of formula (VI), R 57 is hydrogen and C 1~6 In certain embodiments, R 57 is selected from hydrogen. 57 represents hydrogen, as well as the halogens -OH, -SH, and -NH 2 , -NO 2 , -CN, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, R 57 represents hydrogen, as well as the halogens -OH, -SH, and -NH 2 , -NO 2 C optionally substituted with one or more substituents independently selected from -CN, -OMe, and -OMe; 1~6 In certain embodiments, R 57 is hydrogen and C 1~6In certain embodiments, R 57 is hydrogen. In some embodiments, R 57 is selected from methyl, ethyl, n-propyl and isopropyl.

[0214] In certain embodiments, for a compound or salt of formula (VI), R 52 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from.

[0215] In certain embodiments, for a compound or salt of formula (VI), R 52 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl; C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0216] In certain embodiments, for a compound or salt of formula (VI), R 52 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 52 is C 1~6 In certain embodiments, R 52 is selected from methyl, ethyl, and propyl. In certain embodiments, R 52 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0217] In certain embodiments, for a compound or salt of formula (VI), each R 53 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, each R 53 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, each R 53 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, each R 53 is C 1~6 In certain embodiments, R 53 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl.

[0218] In certain embodiments, for a compound or salt of formula (VI), p is 0. In certain embodiments, p is 1. In certain embodiments, p is 2.

[0219] In certain embodiments, for a compound or salt of formula (VI), R 54 is halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 In certain embodiments, R 54 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, R 54 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In certain embodiments, R 54 is C 1~6 In certain embodiments, R 54 is selected from methyl, ethyl, n-propyl, and isopropyl. 54 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 54 is selected from methyl and ethyl. In certain embodiments, R 54 is selected from methyl. In certain embodiments, R 54 is C 1~3 In certain embodiments, R 54 is methyl, -CHF 2 , -CH 2 F and -CF 3 In some embodiments, R 54 is halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN,C 1~6 Alkyl, C 3~6 Carbocyclic and 3- to 6-membered heterocyclic rings (where C 1~6 Alkyl, C 3~6 Carbocyclic and 3- to 6-membered heterocyclic rings are not subject to halogen, -OR56 , -SR 56 , -N(R 56 ) 2 , -NO 2 -, and -CN, each optionally substituted with one or more substituents independently selected from. In some embodiments, R 54 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, and C 3~6 Carbocyclic ring (where C 1~6 Alkyl, and C 3~6 Carbocycles are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 In some embodiments, R 54 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~6 In some embodiments, R 54 are halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 3~6 In some embodiments, R 54 is selected from methyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclobutyl, t-butyl, sec-butyl and n-butyl.

[0220] In certain embodiments, for a compound or salt of formula (VI), each R 55 are halogens, -CN, -OH, -SH -NO 2, -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 55 is selected from methyl, ethyl, and propyl.

[0221] In certain embodiments, for a compound or salt of formula (VI), each R 56 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, for a compound or salt of formula (VI), each R 56 represents hydrogen, halogen, and halogens, -CN, -OH, -SH, -NO 2 , and -NH 2 C optionally substituted with one or more substituents independently selected from 1~3 In certain embodiments, R 56 is selected from methyl, ethyl, propyl, butyl, cyclopropyl, and cyclobutyl. 56 is hydrogen.

[0222] In one aspect, the present specification provides a compound of formula (VI): [ka] or a salt thereof, X 51 is selected from O and S; R 51 teeth, hydrogen, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56, -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from R 52 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 )2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from Each R 53 is halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 54 is hydrogen, halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 55 teeth, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56), and -CN, are independently selected from Each R 56 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 57 represents hydrogen, as well as halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2; Here, the compound is [ka] isn't it.

[0223] In one aspect, the present specification provides a compound of formula (VI): [ka] or a salt thereof, wherein X 51 is selected from O and S; R 51 teeth, hydrogen, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56)C(O)R 56 , -C(O)OR 56 , -OC(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from R 52 teeth, C 2~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from Each R 53 is halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 54 is hydrogen, halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2, -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 55 teeth, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56)C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, are independently selected from Each R 56 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 57 represents hydrogen, as well as halogens, -OR56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2].

[0224] In one aspect, the present specification provides a compound of formula (VI): [ka] or a salt thereof, wherein X 51 is selected from O and S; R 51 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from R 52 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 56 , -SR 56 , -N(R56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 55 (each replaced as necessary) is selected from Each R 53 is halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 , -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, R 54 is hydrogen, halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2, -CN, and halogens, -OR 56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 55 teeth, Halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56 )C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 56 , -SR 56 , -N(R 56 ) 2 , -C(O)R 56 , -C(O)N(R 56 ) 2 , -N(R 56 )C(O)R 56 , -N(R 56 )C(O)N(R 56 ) 2 , -OC(O)N(R 56 ) 2 , -N(R 56)C(O)OR 56 , -C(O)OR 56 , -OC(O)R 56 , -S(O)R 56 , -S(O) 2 R 56 , -NO 2 , =O, =S, =N(R 56 ), and -CN, are independently selected from Each R 56 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from R 57 represents hydrogen, as well as halogens, -OR56 , -SR 56 , -N(R 56 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 alkyl, p is 0, 1, or 2].

[0225] In one aspect, the present specification provides a compound of formula (VI): [ka] or a salt thereof, wherein X 51 is selected from O and S; R 51 teeth, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocyclic rings and 3- to 10-membered heterocyclic rings are not affected by halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6each optionally substituted with one or more substituents independently selected from alkyl, is selected from R 52 teeth, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocyclic rings and 3- to 10-membered heterocyclic rings are not subject to halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6 each optionally substituted with one or more substituents independently selected from alkyl, is selected from R 54 is hydrogen, halogen, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), as well as halogens, -CN, -OH, -SH -NO 2 , -NH 2 , -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , and -NH(C 1~6C optionally substituted with one or more substituents independently selected from 1~6 independently selected from alkyl, R 57 is hydrogen, p is 0].

[0226] In certain embodiments, for a compound or salt of formula (VI), the compound is [ka] and a salt of any one of these.

[0227] In certain embodiments, for a compound or salt of formula (VI), the compound is [ka] and a salt of any one of these.

[0228] In certain embodiments, for a compound or salt of formula (VI), the compound is [ka] and a salt of any one of these.

[0229] In one aspect, the present specification provides a compound of formula (VII): [ka] or a salt thereof, wherein R 61 teeth, hydrogen, Halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R66 , -C(O)OR 66 , -OC(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 66 , -SR66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 (each replaced as necessary) is selected from R 62 teeth, Halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66)C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), and -CN, C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 each of which is optionally substituted with is selected from Each R 63 is halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -NO 2 , -CN, and halogens, -OR 66 , -SR 66 , -N(R 66 ) 2 , -NO 2 and C optionally substituted with one or more substituents independently selected from -CN. 1~6 independently selected from alkyl, Each R 65 teeth, Halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), and -CN, and C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl (which are halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), and -CN, are independently selected from Each R 66 teeth, hydrogen, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6Alkyl), C 3~10 optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; and C 3~10 Carbocycles and 3- to 10-membered heterocycles (which are substituted with halogen, -CN, -OH, -SH, -NO, 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. are independently selected from [p is 0, 1, or 2].

[0230] In certain embodiments, for a compound or salt of formula (VII), R 61 teeth, Halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , and -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), -CN, C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 (each replaced as necessary) is selected from.

[0231] In certain embodiments, for a compound or salt of formula (VII), R 61 teeth, Halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -NO 2 , and -CN, C 2~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl (which are halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR66 , -OC(O)R 66 , -NO 2 , -CN,C 3~10 Optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, where C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 each being replaced as necessary), and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -NO 2 , and -CN, C 1~6 Alkyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 (each replaced as necessary) is selected from.

[0232] In certain embodiments, for a compound or salt of formula (VII), R 61 teeth, Halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -NO2 , and -CN, Halogen, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 C optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. 1~6 Alkyl, and C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl. is selected from.

[0233] In certain embodiments, for a compound or salt of formula (VII), R 61 is C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (each of which is substituted with halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66, -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO 2 , =O, =S, =N(R 66 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 In certain embodiments, R 61 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are each substituted with halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -N(R 66 )C(O)N(R 66 ) 2 , -OC(O)N(R 66 ) 2 , -N(R 66 )C(O)OR 66 , -C(O)OR 66 , -OC(O)R 66 , -S(O)R 66 , -S(O) 2 R 66 , -NO2 , =O, =S, =N(R 66 ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, where C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 In certain embodiments, R 61 is C 5~6 Carbocyclic and 5- to 6-membered heterocyclic rings (which are substituted with halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 carbocycle, 3- to 10-membered heterocycle, and haloalkyl. In certain embodiments, for a compound or salt of formula (VII), R 61 are phenyl and pyridinyl (which are halogen, -CN, -OH, -SH, -NO, respectively). 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl.

[0234] In certain embodiments, for a compound or salt of formula (VII), R 61 teeth, [ka] is selected from.

[0235] In certain embodiments, for a compound or salt of formula (VII), R 62 is halogen, -OR 66 , -SR 66 , -N(R 66 ) 2 , -C(O)R 66 , -C(O)N(R 66 ) 2 , -N(R 66 )C(O)R 66 , -C(O)OR 66 , -OC(O)R 66 , -NO 2 , -CN,C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C 3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 In certain embodiments, R is selected from the group consisting of 5-membered heterocycles optionally substituted with one or more substituents independently selected from 62 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 3~10 Carbocyclic and 3- to 10-membered heterocyclic rings (where C 1~6 Alkyl, C3~10 Carbocycles and 3- to 10-membered heterocycles may be joined by one or more R 65 each optionally substituted with one or more substituents independently selected from:

[0236] In certain embodiments, R 62 are halogens, -CN, -OH, -SH -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 6~10 Carbocyclic and 5- to 6-membered heterocyclic rings (where C 1~6 Alkyl, C 6~10 Carbocyclic rings and 5- to 6-membered heterocyclic rings are not affected by halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , and C 1~6 and 5-membered heterocycles optionally substituted with one or more substituents independently selected from alkyl,

[0237] In certain embodiments, for a compound or salt of formula (VII), R 62 teeth, [ka] (These are halogens, -CN, -OH, -SH and -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 6~10and optionally substituted with one or more substituents independently selected from carbocycle, and 5- to 6-membered heterocycle, where C 1~6 Alkyl, C 6~10 Carbocyclic rings and 5- to 6-membered heterocyclic rings are not affected by halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , and C 1~6 each optionally substituted with one or more substituents independently selected from alkyl.

[0238] In certain embodiments, for a compound or salt of formula (VII), R 62 teeth, [ka] (These are fluoro, chloro, bromo, -CN, -OH, -SH, -NO 2 , -NH 2 , =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl) 2 , -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 6~10 and optionally substituted with one or more substituents independently selected from carbocycle, and 5- to 6-membered heterocycle, where C 1~6 Alkyl, C 6~10 Carbocyclic rings and 5- to 6-membered heterocyclic rings are not affected by halogen, -CN, -OH, -SH, -NO 2 , -NH 2 , and C 1~6 each optionally substituted with one or mor...

Claims

1. Formula (VI): 【Chemistry 193】 or a salt thereof [wherein X ５１ is selected from O and S; R ５１ teeth, hydrogen, ハロゲン、-OR ５６ 、-SR ５６ 、-N(R ５６ ) ２ 、-C(O)R ５６ 、-C(O)N(R ５６ ) ２ 、-N(R ５６ )C(O)R ５６ 、-C(O)OR ５６ 、-OC(O)R ５６ 、-N(R ５６ )C(O)N(R ５６ ) ２ 、-OC(O)N(R ５６ ) ２ 、-N(R ５６ )C(O)OR ５６ 、-S(O)R ５６ 、-S(O) ２ R ５６ 、-NO ２ および-CN、 C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl (each of which is a halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), -CN, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, wherein said C ３～１０ Carbocycles and 3- to 10-membered heterocycles may be formed by one or more R ５５ each substituted as necessary), and C ３～１０ Carbocycles and 3- to 10-membered heterocycles (each of which is substituted with halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), -CN, C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, wherein C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ Carbocycles and 3- to 10-membered heterocycles can be formed by one or more R ５５ (each replaced as necessary) is selected from R ５２ teeth, C １～６ Alkyl, C ２～６ alkenyl, and C ２～６ Alkynyl (each of which is a halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), -CN, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, wherein said C ３～１０ Carbocycles and 3- to 10-membered heterocycles may be formed by one or more R ５５ each substituted as necessary), and C ３～１０ Carbocycles and 3- to 10-membered heterocycles (each of which is substituted with halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), and -CN, C １～６ Alkyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, wherein C １～６ Alkyl, C ３～１０ Carbocycles and 3- to 10-membered heterocycles can be formed by one or more R ５５ (each replaced as necessary) is selected from Each R ５３ is a halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -NO ２ , —CN; halogen, —OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -NO ２ and —CN, optionally substituted with one or more substituents independently selected from １～６ independently selected from alkyl, R ５４ is hydrogen, halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -NO ２ , -CN,C １～６ Alkyl, C ３～１０ Carbocycles and 3- to 10-membered heterocycles (where C １～６ Alkyl, C ３～１０ Carbocycles and 3- to 10-membered heterocycles are substituted with halogen, —OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -NO ２ -CN; Each R ５５ teeth, Halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), and -CN, and C １～３ Alkyl, C ２～３ Alkenyl, C ２～３ Alkynyl (each of which is a halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), and —CN, optionally substituted with one or more substituents independently selected from are independently selected from Each R ５６ teeth, hydrogen, C １～６ Alkyl, C ２～６ alkenyl, and C ２～６ Alkynyl (which are halogen, —CN, —OH, —SH, —NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, —S—C １～６ Alkyl, —N(C １～６ alkyl) ２ , —NH(C １～６ alkyl), C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle; C ３～１０ Carbocycles and 3- to 10-membered heterocycles (which may be substituted with halogen, —CN, —OH, —SH, —NO, respectively) ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, —S—C １～６ Alkyl, —N(C １～６ alkyl) ２ , —NH(C １～６ alkyl), C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl are independently selected from R ５７ represents hydrogen, as well as halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -NO ２ and —CN, optionally substituted with one or more substituents independently selected from １～６ alkyl, p is 0, 1, or 2; The compound is 【Chemistry 194】 is not a compound or a salt thereof.

2. X ５１ The compound or salt of claim 1 , wherein is S.

3. R ５１ but, ハロゲン、-OR ５６ 、-SR ５６ 、-N(R ５６ ) ２ 、-C(O)R ５６ 、-C(O)N(R ５６ ) ２ 、-N(R ５６ )C(O)R ５６ 、-C(O)OR ５６ 、-OC(O)R ５６ 、-N(R ５６ )C(O)N(R ５６ ) ２ 、-OC(O)N(R ５６ ) ２ 、-N(R ５６ )C(O)OR ５６ 、-S(O)R ５６ 、-S(O) ２ R ５６ 、-NO ２ 、および-CN、 C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl (each of which is a halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), -CN, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, wherein said C ３～１０ Carbocycles and 3- to 10-membered heterocycles may be formed by one or more R ５５ each substituted as necessary), and C ３～１０ Carbocycles and 3- to 10-membered heterocycles (each of which is substituted with halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), -CN, C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, wherein C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ Carbocycles and 3- to 10-membered heterocycles can be formed by one or more R ５５ (each replaced as necessary) 2. The compound or salt of claim 1 selected from:

4. R ５１ but, C ５～６ Carbocycles and 5- to 6-membered heterocycles (each of which is substituted with halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -N(R ５６ )C(O)N(R ５６ ) ２ , -OC(O)N(R ５６ ) ２ , -N(R ５６ )C(O)OR ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -S(O)R ５６ , -S(O) ２ R ５６ , -NO ２ , =O, =S, =N(R ５６ ), -CN, C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, wherein C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ Carbocycles and 3- to 10-membered heterocycles can be formed by one or more R ５５ (each replaced as necessary) 2. The compound or salt of claim 1 selected from:

5. R ５１ but, C ５～６ Carbocycles and 5- to 6-membered heterocycles (which may be halogen, —CN, —OH, —SH, —NO, ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, —S—C １～６ Alkyl, —N(C １～６ alkyl) ２ , —NH(C １～６ alkyl), C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl 2. The compound or salt of claim 1 selected from:

6. R ５１ but, Phenyl and pyridinyl (which are halogen, —CN, —OH, —SH, —NO, respectively) ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, —S—C １～６ Alkyl, —N(C １～６ alkyl) ２ , —NH(C １～６ alkyl), C １～６ Alkyl, C ２～６ Alkenyl, C ２～６ Alkynyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, 3- to 10-membered heterocycle, and haloalkyl 2. The compound or salt of claim 1 selected from:

7. R ５１ but, 【Chemistry 195】 2. The compound or salt of claim 1 selected from:

8. R ５７ 2. The compound or salt of claim 1, wherein is selected from hydrogen.

9. R ５２ but, C １～６ Alkyl, C ２～６ alkenyl, and C ２～６ Alkynyl (each of which is a halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -NO ２ , -CN,C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle and 3- to 10-membered heterocycle, wherein said C ３～１０ Carbocycles and 3- to 10-membered heterocycles may be formed by one or more R ５５ each substituted as necessary), and C ３～１０ Carbocycles and 3- to 10-membered heterocycles (each of which is substituted with halogen, -OR ５６ , -SR ５６ , -N(R ５６ ) ２ , -C(O)R ５６ , -C(O)N(R ５６ ) ２ , -N(R ５６ ) C(O)R ５６ , -C(O)OR ５６ , -OC(O)R ５６ , -NO ２ , -CN,C １～６ Alkyl, C ３～１０ optionally substituted with one or more substituents independently selected from carbocycle, and 3- to 10-membered heterocycle, wherein C １～６ Alkyl, C ３～１０ Carbocycles and 3- to 10-membered heterocycles can be formed by one or more R ５５ (each replaced as necessary) 2. The compound or salt of claim 1 selected from:

10. R ５２ is C １～６ 10. The compound or salt of claim 9, wherein the alkyl is selected from the group consisting of aryl, aryl, arylsulfonyl ...

11. R ５２ 11. The compound or salt of claim 10, wherein is selected from methyl, ethyl, and propyl.

12. 2. The compound or salt of claim 1, wherein p is 0.

13. R ５４ But halogen, -CN, -OH, -SH, -NO ２ , and —NH ２ C optionally substituted with one or more substituents independently selected from １～６ 2. The compound or salt of claim 1, wherein the aryl group is alkyl.

14. R ５４ 2. The compound or salt of claim 1, wherein is selected from methyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclobutyl, t-butyl, sec-butyl and n-butyl.

15. The compound or salt of claim 14, wherein R 54 is selected from methyl.

16. The compound is 【Chemical 206】 or a salt thereof.

17. The compound of claim 1 【Chemical 207】 or a salt thereof.

18. The compound of claim 17, 【Chemical 208】 or a salt thereof.

19. A pharmaceutical composition comprising a compound or salt according to any one of claims 1 to 18.

20. A composition comprising a compound or salt according to any one of claims 1 to 18 for treating activity-induced muscle damage, a neuromuscular condition, a movement disorder, or a metabolic myopathy.

21. 21. The composition of claim 20, wherein the neuromuscular condition is selected from Duchenne muscular dystrophy, Becker muscular dystrophy, myotonic dystrophy type 1, myotonic dystrophy type 2, facioscapulohumeral muscular dystrophy, oculopharyngeal muscular dystrophy, limb-girdle muscular dystrophy, tendonitis, and carpal tunnel syndrome.

22. 21. The composition of claim 20, wherein the neuromuscular condition is Duchenne muscular dystrophy, Becker muscular dystrophy, or limb-girdle muscular dystrophy.

23. 21. The composition of claim 20, wherein the movement disorder comprises muscle spasticity.

24. 24. The composition of claim 23, wherein the muscle spasms are associated with multiple sclerosis, Parkinson's disease, Alzheimer's disease, cerebral palsy, injury, stroke, traumatic brain injury, spinal cord injury, hypoxia, meningitis, encephalitis, phenylketonuria, or amyotrophic lateral sclerosis.

25. The composition described in claim 20, wherein the metabolic myopathy is McArdle's disease.

26. 21. The composition of claim 20, wherein the composition is administered in an amount sufficient to reduce involuntary muscle contractions.

27. 27. The composition of claim 26, wherein the composition is administered in an amount sufficient to reduce involuntary muscle contractions by at least 10%.

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