Sunscreen compositions

Abstract

To provide a sunscreen composition to make the best use of both beneficial sunscreen ingredients, bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT) and zinc oxide, as beneficial formulations.SOLUTION: The present invention provides a sunscreen composition comprising non-nano ZnO and bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT) in a ratio sufficient to produce a synergistic effect in UV protection.SELECTED DRAWING: None

Description

[Technical field]

[0001] (CROSS REFERENCE TO RELATED APPLICATIONS) This application was filed on June 2, 2016 under 35 U.S.C. §109(e). This application claims priority to U.S. Provisional Application No. 62 / 344,795, filed in its entirety herein. The contents of which are incorporated herein by reference.

[0002] TECHNICAL FIELD OF THE PRESENT APPLICATION The present invention belongs to the technical field of cosmetic sunscreen compositions and raw material applications, in particular, bis- Ethylhexyloxyphenol Methoxyphenyl Triazine (BEMT) and Non-Nano Broad spectrum sunscreen compositions containing zinc oxide. [Background technology]

[0003] Solar radiation contains about 5% ultraviolet (UV) radiation, which is in the range of 200 nm to 400 nm. They have wavelengths ranging from 320 to 400 nm (UV-A) and can be divided into three regions: , 290~320nm (UV-B), 200~290nm (UV-C). Most UVC UVA and UVB rays are absorbed by the ozone layer and do not reach the Earth's surface, but both UVA and UVB rays penetrate the atmosphere. It was once thought that only UVB was a concern, but UVA is now known to be a cause for concern. With the increasing research and knowledge gained about the damage that can be caused to the human body, It has been recognized that both VA and UVB can cause a variety of health-related problems. Exposure to UV-A and UV-B rays for hours can cause redness and irritation of the skin, and prolonged exposure to UV-B rays can cause redness and irritation of the skin. Exposure can cause sunburn, premature skin aging, hair damage, eye damage (including cataracts), and melanoma. and other skin cancers. Protection from UV-B radiation is an important part of personal care.

[0004] Many UV-B sunscreens are known for their safe use in protecting against UV radiation. While these products are widely used and approved, the search for new ways to protect against UVA radiation continues. Developing broad-spectrum sun care products that can protect against both UV-A and UV-B radiation The goal is to achieve this goal, and it has become clear that this is a significant effort in this field. Sun Protection Factor (SPF) and UVA Protection Factor (PFA) are commonly measured photoprotective groups. The nature of the composition and its effect on the skin from exposure to both UV-B and UV-A radiation. Each protection is shown below.

[0005] Zinc oxide is inert and will not cause allergies or stinging in consumers with sensitive skin. Therefore, it is a globally approved sunscreen active ingredient and is widely used in sunscreen formulations. Zinc oxide is recognized as a UVA sunscreen ingredient that primarily absorbs UVA rays. Research has shown that micro-ZnO induces persistent pigment darkening in vivo. As shown by the PFA value measured by the ment darkening method, sufficient UVA However, ZnO only provides weak UVB protection. (D. Schlossman and Y. Shao, "Sunscreens: Regul ations and Commercial Development, 3rd ed., N. Saath, Taylor and Francis, March 2005, "Inorganic UV Filters" In particular, the primary size of ZnO is smaller than that of the non-nano domain (D50>100 nm). When it gets larger, the protective effect in both the UVA and UVB regions is equivalent to that of nano-ZnO. Therefore, it is better to use SPF 30 or higher with broad spectrum protection. To meet performance requirements, ZnO is mixed with other organic sunscreens and / or titanium dioxide. It is often used in conjunction with

[0006] Bis-ethylhexyloxyphenol under the trade name Tinosorb® S Methoxyphenyltriazines (BEMTs) are used in sunscreen formulations for UVA protection. It is manufactured by BASF (formerly Ciba) in 2013. However, BASF scientists (Uli Osterwalder et al., April 17-19, 2007, Paris, BEMT in In-Cosmetics: How to Achieve New UVA Protection Standards The performance of was mediocre: Active: BEMT 4% SPF in vivo = 7.3 ± 1.2 UVA-PF in vivo = 7.6 ± 2.2.

[0007] Therefore, both BEMT and zinc oxide are considered sunscreen active ingredients in sunscreen products. Despite the fact that these two commonly used sunscreens How to best use the components in a useful formulation remains a challenge, especially when the size of ZnO is large. This remains a challenge. Summary of the Invention

[0008] The present invention relates to the use of BEMT and Based on the surprising discovery of a synergistic effect between non-nano ZnO and BEMT at a usage level of 2 wt.% When not exceeding 100 mg / kg, the combination provides broad spectrum and high UV protection. The invention relates to BEMT non-nano ZnO with a median primary particle size exceeding 100 nm. Use is provided where the level of non-nano ZnO is 25 wt% or less.

[0009] Thus, in one aspect, the present invention provides a method for producing nano-ZnO and bis-ethylhexyl phosphate nanoparticles. methoxyphenol methoxyphenyl triazine, and optionally other organic or inorganic UV filters. The present invention provides a sunscreen composition comprising a filter.

[0010] In another aspect, the composition of the present invention comprises any of the embodiments disclosed herein. Cosmetic or personal care formulations containing such sunscreen compositions, or combinations thereof, are provide.

[0011] In another aspect, the composition of the present invention comprises any of the embodiments disclosed herein. Articles containing such sunscreen compositions or combinations thereof are provided.

[0012] Other aspects and advantages of the present invention are set forth in the detailed description and claims set forth below. This will be better understood. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] Detailed Description of the Invention Contrary to conventional belief that larger grain ZnO typically provides less effective UV protection It was discovered that a synergistic effect exists when non-nano ZnO is combined with BMET. The sunscreen composition of the present invention is made of ZnO, particularly ZnO having a median primary particle size of more than 100 nm. It contains non-nano ZnO and BEMT.

[0014] With up to 25 wt% non-nano ZnO and up to 2 wt% BEMT Surprisingly, a high synergistic effect between ZnO and BEMT was found. According to available performance data, the calculated SPF and PFA are less than 15 and 20, respectively. Sunscreen products with such SPFs are expected to have a UV protection level of less than 8. This would require a warning label on the product, thus affecting its marketability. The combination of non-nano ZnO and BEMT of the present invention each has an SPF of greater than 35. PFA was tested to be higher than 25.

[0015] Thus, in one aspect, the present invention provides a method for producing a sunscreen composition comprising the steps of: The purpose of this study is to apply a combination of BEMT and BEMT.

[0016] In one aspect, the present invention provides a method for the preparation of nano-ZnO nanoparticles in a ratio that provides synergistic UV protection. and BEMT.

[0017] In one embodiment, the synergy is a corresponding mathematical function based on the values ​​of the two individual components. Increased, measured in vivo, compared to calculated SPF and / or PFA values Sun Protection Factor (SPF) value, increased UVA Protection Factor (PFA) value, or both. will be done.

[0018] In some embodiments, the increased SPF value is at least 15, at least 16. In some embodiments, the SPF value is at least 18, at least 20. At least 25, at least 30, or at least 35.

[0019] In some embodiments, the increased PFA value is at least 8, at least 10, At least 12, or at least 15. In some embodiments, the PFA value is at least 18, at least 20, at least 22, or at least 24.

[0020] Those skilled in the art will be able to achieve the desired combination of SPF and PFA values ​​based on this disclosure. In order to achieve this, the amount and proportion of non-nano ZnO and BMET could be adjusted.

[0021] In one embodiment, the ZnO has a median primary particle size ( median primary particle size).

[0022] In another embodiment, the ZnO has a median primary particle size in the range of about 20 to 100 nm. has.

[0023] In another embodiment, the ZnO has a median primary particle size of about 100 nm or more ("non-ZnO"). The compound is ZnO.

[0024] In another embodiment, the ZnO has a median primary particle size in the range of about 100 to 300 nm. It has a diameter.

[0025] In another embodiment, the ZnO has a median primary particle size in the range of about 100 to 200 nm. It has a diameter.

[0026] In another embodiment, the ZnO has a median primary particle size in the range of about 200 to 300 nm. It has a diameter.

[0027] In one embodiment, the ZnO is uncoated.

[0028] In another embodiment, the ZnO is coated with a different oxide compound.

[0029] In another embodiment, the different oxide compound is silica.

[0030] In another embodiment, ZnO is selected from the group consisting of silanes, silicones, organotitanates, fats, etc. The group consisting of acids, metal soaps, polyols, dimethicones, and combinations thereof It is further coated with an organic material selected from the following:

[0031] In another embodiment, the ZnO content is at a level of about 25% by weight or less.

[0032] In another embodiment, the ZnO content is at a level ranging from about 0.1% to about 25% by weight. It is.

[0033] In another embodiment, the ZnO content is at a level ranging from about 1% to about 20% by weight. do.

[0034] In another embodiment, the ZnO content is at a level ranging from about 2% to about 15% by weight. do.

[0035] In another embodiment, the ZnO content is at a level ranging from about 3% to about 10% by weight. do.

[0036] In another embodiment, bis-ethylhexyloxyphenol methoxyphenyl tri The azine (BEMT) content is at a level of about 2% by weight or less.

[0037] In another embodiment, the BEMT content is at a level ranging from about 0.1% to about 2% by weight. It is.

[0038] In another embodiment, the BEMT content ranges from about 0.2% to about 1.8% by weight. It's Bell.

[0039] In another embodiment, the BEMT content ranges from about 0.3% to about 1.6% by weight. It's Bell.

[0040] In another embodiment, the BEMT content ranges from about 0.5% to about 1.5% by weight. It's Bell.

[0041] In another embodiment, the sunscreen composition is a non-adhesive formulation for the care of skin, hair or nails. Color (unpigmented).

[0042] In another embodiment, the sunscreen composition is a foundation, lipstick, nail polish, and pressed powder, etc. a color cosmetic).

[0043] In another embodiment, the sunscreen composition contains additional organic or inorganic UV filters. Further includes:

[0044] In some embodiments, the sunscreen composition comprises a sunless tanning agent, an antimicrobial agent, A depigmenting agent, an anti-aging agent, an anti-fungal agent, an insect repellent, and a combination thereof. The composition further comprises a topical active agent of choice.

[0045] In another aspect, the present invention provides a method for producing a medicament for use in a method for treating a pulmonary arthritis, comprising administering to a patient a medicament for which the medicament is administered, the patient being treated with ... A qualitatively described and illustrated sunscreen composition is provided.

[0046] In another aspect, the composition of the present invention comprises any of the embodiments disclosed herein. The present invention provides cosmetic or personal care formulations containing such sunscreen compositions or combinations thereof. Provide.

[0047] In another aspect, the composition of the present invention comprises any of the embodiments disclosed herein. The present invention provides an article comprising such a sunscreen composition or a combination thereof. However, any containers, tubes, bottles, cases, boxes, bags, spray devices, etc. that contain sunscreen It may be in the form of a container for the composition and may be of any shape, style, or color. The container may be made of any material suitable for containing a sunscreen composition.

[0048] In another aspect, the composition of the present invention comprises any of the embodiments disclosed herein. Uses of such sunscreen compositions, or combinations thereof, are provided.

[0049] In another aspect, the present invention provides a composition according to the first aspect of the present invention for obtaining an SPF of higher than 15. The SPF is preferably greater than 20, more preferably greater than 25. , and even more preferably higher than 30. The compositions prepared in Table 1 of the Examples have a high The SPF value was shown.

[0050] Thus, the present invention provides a high S sunscreen composition that contains relatively small amounts of sunscreen compounds and low cost materials. To provide a PF sunscreen composition, thus achieving overall benefits at a lower cost.

[0051] The sunscreen formulations of the present invention may be used in combination with non-nano ZnO and BEMT, as will be appreciated by those skilled in the art. It may contain one or more other organic or inorganic UV filters as long as the synergistic effect is maintained. Cut.

[0052] Inorganic UV filters include titanium dioxide (TiO2), iron oxides (e.g., Fe2O3), and silica, and the like.

[0053] Numerous organic UV filters have been reported in the cosmetic field, including but not limited to: , benzophenone-3 (BP3) and benzophenone-4 (BP4) Non-salicylic acids: homosalate (HMS), 2-ethylhexyl salicylate (EHS), etc. Lithium salts; Ethylhexyl dimethyl PABA (OD-PABA), 4-p-aminoammonium salt p-Aminobenzoic acid (PABA) and derivatives such as phenylbenzoic acid (PABA); Phenyldibenzimidazole tetrasulfonic acid (PMDSA), Phenyldibenzimidazole tetrasulf Benzimidazole derivatives such as disodium phosphate (bisdistyrizolate disodium) ;Ethylhexyl triazone (OT), diethylhexyl butamido triazone (DBT) , benzotriazoles, drometrizole trisiloxane (DRT), methylene bis- Benzotriazolyltetramethylbutylpheno(bis(triazole)) (MBP) Triazines; dibenzoyls such as butyl methoxydibenzoylmethane (BM-DBM) Methane derivatives; ethylhexyl methoxycinnamate (OMC), isoamyl p-meth Cinnamic acid esters such as dimethylcinnamate (IMC); and terephthalide dican. Benzylidine sulfonic acid (PDSA), 3-benzylidene camphor (3BC), benzylidene Camphorsulfonic acid (BCSA), 4-methylbenzylidene camphor (4-MBC) , Polyacrylamide methyl benzylidene camphor (PBC), Camphor benzalko and camphor derivatives such as camphornium methosulfate (CBM).

[0054] Among organic UV filters, there are compounds of the dibenzoylmethane class that are particularly useful. , including but not limited to, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-Methyldibenzoylmethane, 4-Methyl-dibenzoyl-ethane, 4-Isopropyl Dibenzoylmethane, 4-tert-butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane Benzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyl- Dibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane 2-Methyl-5-tert-butyl-4'-methoxy-dibenzoylmethane, 2,4 -Dimethyl-4'-methoxydibenzoylmethane, 2,6-dimethyl-4-tert-butyl ethyl-4'-methoxy-dibenzoylmethane and the like.

[0055] In the present invention, the above organic U is used to further enhance or adjust the desired UV protection effect. All of the V filters can be used.

[0056] The sunscreen formulation also comprises a cosmetically acceptable base, a surfactant, a diluent, and Other optional ingredients, such as those commonly known to those skilled in the art and used in the personal care and cosmetics industries. The composition may contain various other ingredients as may be acceptable to those skilled in the art. No. 6 / 41614, U.S. Patent Application Publication No. 2013 / 0266527, and U.S. Pat. See US Pat. No. 9,649,263, all of which are incorporated herein by reference in their entireties. Be absorbed.

[0057] In some preferred embodiments, the sunscreen formulations of the present invention contain the ingredients listed in Table 1. or functional equivalents and / or variants thereof.

[0058] The sunscreen formulation of the present invention is preferably, but not limited to, Depending on the base used, they may be prepared in the form of creams, lotions, gels or emulsions. A preferred solid form of the composition is a cream or lotion. Creams are typically is defined as a composition that does not flow out of the container at 25°C when inverted. A solution is a composition that flows out of a container at 25°C when inverted (e.g., Br ummer, R.; Rheology Essentials of Cosmetic and Food Emulsions, Spr inger-Verlag Berline Heidelberg,81-83(20 See 06).

[0059] The sunscreen compositions of the present invention may contain antioxidants, binders, biological additives, buffers, colorants, Thickeners, polymers, astringents, fragrances, humectants, opacifiers, conditioners, peeling agents, pH adjusters, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, A wide range of other optional ingredients may be included, such as skin healing agents. Suitable for use in the manufacture of various non-limiting cosmetic and cosmetic products commonly used in the skin care industry. CTFA Cosmetic Ingredients, which lists cosmetic and pharmaceutical ingredients Handbook, 2nd ed., 1992.

[0060] As used herein, the term "non-nano ZnO" refers to the median primary particle size of ZnO. This means that the median primary particle size is greater than 100 nm. , measuring the particles in photographs obtained using a transmission electron microscope or a scanning electron microscope Where applicable, the number-weighted distribution of the shortest dimension is used in the size analysis and It is used for reference and discussion.

[0061] As used herein, the term "about" means that a number is within up to ±20%, preferably ±10%. , and more preferably, may vary within ±5%. As used herein, the terms "a," "an," and " In general, the singular or plural of a noun is used. When either form is used, both the singular and the plural of the noun are meant.

[0062] The following non-limiting examples further illustrate certain aspects of the present invention. EXAMPLES

[0063] Surprisingly, 7.15% non-nano ZnO and 1.4% B tested in vivo The formulation exemplified in Table 1, which includes EMT, has an SPF of 38.89 (Table 2), a PF of 25.27 (Table 3), and A and 377 nm were shown to be critical wavelengths (Table 3). PF30+, i.e. in accordance with FDA and Cosmetic Europe regulations It has broad spectrum UV protection and UVA protection rating of ++++ according to Japanese regulations. do.

[0064] [Table 1]

[0065] procedure: 1. Parts 1 and 2 were mixed and heated to 80°C. 2. Part 3 ingredients were slurried and added to Parts 1 and 2 with mixing. 3. Mix ingredients from Part 4 and heat to 80°C. 4. While homogenizing, mix the mixture of parts 1-3 with the mixture of part 4. 5. Cool to 50° C. and add Part 5 to the mixture of Parts 1-4.

[0066] Summary of test results:

[0067] [Table 2]

[0068] [Table 3]

[0069] The foregoing examples or preferred embodiments are provided for illustrative purposes only and are not intended to limit the scope of the present invention. Numerous variations and combinations of the above features are included, but are not limited to the above. may be utilized without departing from the invention as defined in the claims. All references cited herein are incorporated by reference in their entirety for all purposes. .

Claims

1. Non-nano ZnO and bis-ethylhexyl in a ratio that provides synergy in UV protection. A sunscreen composition comprising oxyphenol methoxyphenyl triazine (BEMT).

2. The synergistic effects are compared to the corresponding mathematically calculated SPF and / or PFA values. As a result, increased Sun Protection Factor (SPF) values, increased UVA Protection Factor (PFA) values, and 10. The sunscreen composition of claim 1, comprising either or both of these.

3. Having an SPF value of at least 15 or a PFA value of at least 8, or both The sunscreen composition according to claim 1 or 2.

4. Having an SPF value of at least 16 or a PFA value of at least 10, or both The sunscreen composition according to claim 1 or 2.

5. Having an SPF value of at least 20 or a PFA value of at least 12, or both The sunscreen composition according to claim 1 or 2.

6. Having an SPF value of at least 25 or a PFA value of at least 15, or both The sunscreen composition according to claim 1 or 2.

7. The non-nano ZnO has a median primary particle size of about 100 nm to about 300 nm. The sunscreen composition according to any one of claims 1 to 6, having a particle size of 100 microns. 。

8. The nano-ZnO has less than 1.5% particles with a particle size of 100 nm or less.

13. The sunscreen composition according to claim 12 .

9. A sunscreen according to any one of the preceding claims, wherein the non-nano ZnO is uncoated. Composition.

10. 9. The method according to claim 1, wherein the non-nano ZnO is coated with a different oxide compound. Item 1. A sunscreen composition according to item 1.

11. 11. The sunscreen composition of claim 10, wherein the different oxide compound is silica.

12. The non-nano ZnO is a silane, a silicone, an organic titanate, a fatty acid, a metal stone, selected from the group consisting of soaps, polyols, dimethicones, and combinations thereof; A sunscreen according to any one of claims 1 to 11, further coated with an organic material comprising composition.

13. 1. The method of claim 1, further comprising the step of:

3. The sunscreen composition according to any one of claims 2 to 12.

14. 14. The method of claim 13, wherein the non-nano ZnO is at a level between about 1% and about 20% by weight. Sunscreen composition.

15. 14. The method of claim 13, wherein the non-nano ZnO is at a level between about 2% and about 15% by weight. Sunscreen composition.

16. 14. The method of claim 13, wherein the non-nano ZnO is at a level between about 3% and about 10% by weight. Sunscreen composition.

17. Bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT) was added approximately 14. The method according to claim 1, comprising at a level between 0.1% and about 2% by weight. The sunscreen composition described above.

18. 14. The method of claim 13, wherein the BEMT is at a level between about 0.2% and 1.8% by weight. Sunscreen composition.

19. 14. The method of claim 13, wherein the BEMT is at a level between about 0.5% and 1.5% by weight. Sunscreen composition.

20. 18. The composition according to claim 1, which is unpigmented for the care of the skin, hair or nails.

2. A sunscreen composition according to claim 1.

21. A sunscreen according to any one of the preceding claims which is a lotion or cream. composition.

22. Foundation, lipstick, nail polish, and pressed powder Any one of claims 1 to 17, which is a color cosmetic selected from the group consisting of:

1. A sunscreen composition according to claim 1.

23. 23. The composition according to claim 1, further comprising an organic or inorganic UV filter. Sunscreen composition.

24. 23. The inorganic UV filters are titanium dioxide, iron oxide, and silica. The sunscreen composition according to claim 1.

25. The organic UV filters are benzophenone-3 (BP3) and benzophenone-4 Benzophenones such as (BP4); Homosalate (HMS), 2-ethylhexylsalicylate (HMS), Salicylates such as ethylhexyl dimethyl PABA (OD-P p-aminobenzoic acid (PABA) such as 4-p-aminobenzoic acid (PABA) and derivatives; phenylbenzimidazole sulfonic acid (PMDSA), phenyldibenzamide Disodium zimidazole tetrasulfonate (bisdistyrizole disodium), etc. Benzimidazole derivatives of ethylhexyl triazone (OT), diethylhexyl b Thamidotriazon (DBT), benzotriazoles, drometrizole trisiloxane (DRT), methylene bis-benzotriazolyl tetramethylbutylpheno (biscotri triazines such as butyl methoxydibenzoylmethane (BM- dibenzoylmethane derivatives such as ethylhexyl methoxycinnamate (O cinnamic acid esters such as isoamyl p-methoxycinnamate (IMC), isoamyl p-methoxycinnamate (IMC), etc. and terephthalidenedicamphorsulfonic acid (PDSA), 3-benzylidenecamphor - (3BC), benzylidene camphorsulfonic acid (BCSA), 4-methylbenzylidene 4-Methylbenzylidene camphor (4-MBC), polyacrylamidomethylbenzylidene camphor (PB C), and camphor benzalkonium methosulfate (CBM) 24. The sunscreen composition of claim 23, wherein the sunscreen composition is selected from the group consisting of:

26. The organic UV filter is 4-tert-butyl-4'-methoxydibenzoylmethacrylate. 2-Methyldibenzoylmethane, 4-Methyl-dibenzoyl-ethane, 4-Isopropyl Pyrdibenzoylmethane, 4-tert-butyldibenzoylmethane, 2,4-dimethyl Dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyl Dibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoyl Methane, 2-methyl-5-tert-butyl-4'-methoxy-dibenzoylmethane, 2 , 4-dimethyl-4'-methoxydibenzoylmethane, and 2,6-dimethyl-4-t Dibenzoyl selected from the group consisting of tert-butyl-4'-methoxydibenzoylmethane 24. The sunscreen composition of claim 23, which is an ylmethane derivative.

27. Sunless tanning agents, antibacterial agents, depigmenting agents, anti-aging agents, antifungal agents, insect repellents, and The composition of any one of claims 1 to 23, further comprising a topical active agent selected from the group consisting of:

2. A sunscreen composition according to claim 1.

28. 2. The sunscreen composition of claim 1, substantially as described and shown in Table 1.

29. A cosmetic or cosmetic product comprising the sunscreen composition according to any one of claims 1 and 28. Sonalcare formulation.

30. 29. An article comprising the sunscreen composition of any one of claims 1 and 28.

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