Separator that easily falls off

Abstract

To provide a separator with a movable closing connector and a needleless connector that are likely to be separated from each other to prevent leakage of a liquid medication or blood even when a patient moves unexpectedly and can be used repeatedly when being sterilized with alcohol cotton.SOLUTION: A movable closing connector 22 includes a body, a first connection part, and a first elastic valve. The body includes a cylinder part and a first engaging part. The first engaging part is a projecting block and provided on the cylinder part. A needleless connector includes a housing, a second connection part, and a second elastic valve. The housing or the second connection part includes a second engaging part. The second engaging part is a projecting block. The force with which the first engaging part is fixed to the second engaging part is 1.4 to 8.1 Newton meters, and thereby exerts effect of being likely to be separated.SELECTED DRAWING: Figure 4

Description

[Technical field]

[0001] The present invention relates to a separator used in an infusion system, and in particular to a separator that is prone to falling off. [Background technology]

[0002] US Patent US10688295B2 discloses a drug mixing device, the drug mixing procedure of which includes the following steps: According to the doctor's instructions, a vial bottle containing a specific ingredient is taken out, and the inside of the vial contains a powder of the specific ingredient; According to the doctor's instructions, a soft bag containing a dilution solution (infusion liquid bag) is taken out; The vial is fitted into the integral vial adapter of the connection part (needleless additive port), and the puncturing member of the vial adapter is inserted into the cap of the vial (IV The soft bag is placed on the top and the vial is placed on the bottom, and the soft bag is pushed out, so that the dilution solution in the soft bag passes through the opening and passage of the puncture part, the second flow path of the discharge part, the first flow path of the connection part and the insertion needle, and then enters the inside of the vial; the powder in the vial can be mixed slightly by shaking the vial to obtain a highly concentrated drug solution; then the soft bag is placed on the bottom and the vial is placed on the top; the soft bag is pushed out, and the air in the soft bag passes through the through hole and long hole of the puncture part, the second flow path of the discharge part, the first flow path of the connection part and the insertion needle, and then enters the inside of the vial, and the liquid in the vial is sucked out by loosening the hand. This step is repeated to ensure that the liquid in the vial is completely sucked into the soft bag.

[0003] The injection procedure of a conventional drug mixing device includes the following steps: step (a), removing the plug of the plug connector (administration port) from the other end of the tubular body; step (b), placing an infusion set at the other end of the tubular body and passing it through a sealing membrane, so that the infusion set communicates with the second flow path of the outlet part through the third flow path of the tubular body; step (c), placing a soft bag on top and an infusion set on the bottom, and the diluted drug in the soft bag passes through the piercing hole and long hole of the puncture part, the second flow path of the outlet part, the third flow path of the tubular body and the infusion set in that order, and enters the patient's body.

[0004] However, in the process of passing through the long hole of the puncture part, the high-concentration drug solution in the vial cannot be sucked up in one go due to the intrusion of air, and a part of the high-concentration drug solution adheres to the long hole of the puncture part and remains there. In the process of the air in the soft bag passing through the long hole of the puncture part, the high-concentration drug solution that adheres to the inner wall of the passage of the puncture part is pushed into the space between the second flow path of the discharge part and the insertion hole by the air, and the high-concentration drug solution that remains blocked by the tube is formed. Even if the soft bag is loosened, the high-concentration drug solution that remains in the space between the second flow path of the discharge part and the insertion hole cannot be pushed into the soft bag by the air flow. Therefore, when the drug mixing procedure is repeated, the remaining high-concentration drug solution fills the space between the second flow path of the discharge part and the insertion hole due to the pushing out of air.

[0005] The high-concentration drug solution remaining in the space between the second flow path of the discharge part and the insertion hole is not diluted and is therefore highly concentrated. When a nurse uses a conventional drug mixing device to perform an injection procedure, the high-concentration drug solution remaining in the space between the second flow path of the discharge part and the insertion hole enters the patient's body first, and the diluted drug in the soft bag enters the patient's body afterwards. After the remaining high-concentration drug solution enters the patient's body, it may cause side effects. As a result, patients often feel unwell at the beginning of the injection procedure. When such a conventional drug mixing device is used on patients who require precise dosage during drug injection, such as pregnant women and seriously ill patients, it often leads to serious consequences and even death.

[0006] Some nurses who have noticed the above situation have decided to drain the high concentration of medicinal liquid remaining in the space between the second flow path of the discharge part and the insertion hole from the third flow path of the tube body after step (a) and before step (b) of the injection procedure. However, this method directly reduces the amount of medicinal liquid injected into the patient's body, which is not in line with the doctor's instructions, reducing the therapeutic effect and causing drug waste.

[0007] Furthermore, in step (c) of the injection procedure of the conventional medicine mixing device, the first flow path of the connection part and the second flow path of the discharge part are still connected, so some of the diluted medicine will return to the inside of the vial from the second flow path of the discharge part through the first flow path of the connection part and the insertion needle, thereby reducing the amount of medicinal liquid injected into the patient's body and not conforming to the doctor's instructions, thereby reducing the therapeutic effect and causing drug waste.

[0008] In addition, since the connection does not have a sealing effect, when the vial is removed from the connection, the remaining high-concentration liquid medicine may leak out through the connection. Therefore, the conventional drug mixing device can only be used once and cannot be used repeatedly.

[0009] In addition, the conventional infusion system includes a drug mixing device, an infusion set, a distributor, a separator, and an indwelling needle. Since manic patients tend to move around on their own, the distributor and the separator are easily separated, and the indwelling needle and the artificial blood vessel are also easily separated, which causes the drug solution and blood to leak to the outside.

[0010] US Patent US6651956B2 discloses a slit type swabable valve, US Patent US9415199B2 discloses a closed type connector, and US Patent US10201693B2 also discloses a closed type connector. The above three patents can be installed in the connection of the prior art needleless control valve shown in FIG. 1 of US10688295B2 and used to connect with a syringe. The syringe can inject high concentration drug solution into the soft bag by the drug mixing device of the above patent combination. The slit type swabable valve has a closing effect, which can solve the problem of the connection of US Patent US10688295B2 having no closing effect. Therefore, the drug mixing device of the above patent combination can be used repeatedly. Unfortunately, the above patent combination cannot solve other problems of US Patent US10688295B2.

[0011] US Patent US11235135B2 discloses a need-free infusion closed connector for preventing leakage of a medicinal liquid, which includes a first connection assembly and a second connection assembly. The first connection assembly includes a first cylindrical part forming a first opening and a first elastic valve tending to seal the first opening. The second connection assembly includes a second cylindrical part forming a second opening and a second elastic valve tending to seal the second opening. The first elastic valve tends to seal the first opening of the first cylindrical part, and the second elastic valve tends to seal the second opening, thereby preventing leakage of the medicinal liquid remaining in the syringe and infusion conduit connection assembly and the vial and the connection assembly at the human body end, and further, when connecting and withdrawing the medicinal liquid after adding or infusing the medicinal liquid, the connector can be closed in both directions to prevent leakage. Summary of the Invention [Problem to be solved by the invention]

[0012] The main objective of the present invention is to provide a separator that is easy to remove, so that even if the patient moves around on his / her own, the movable closure connector and the needleless connector can be quickly separated to prevent leakage of medicinal fluid or blood, and can be used repeatedly without the need for disinfection with alcohol cotton or replacement. [Means for solving the problem]

[0013] In order to achieve the above object, the present invention provides a separator that is easy to fall off, the separator comprising: a valve body; a threaded structure having an inner conduit, the female thread of a first end of the valve body being threaded into the male thread of the first end of the valve body, the threaded structure being defined as an inlet end of the separator; a discharge end, the first end of which is installed at a second end of the valve body; and an interlocking needleless connector module, the interlocking needleless connector module comprising a movable closure connector and a needleless connector, the movable closure connector comprising a body, a first coupling part and a first elastic valve, The main body includes a cylindrical portion, a conduit, a positioning portion, and a first engagement portion, the conduit is disposed inside the cylindrical portion and has a first passage and a first opening, the positioning portion is located inside the cylindrical portion and disposed outside the conduit, the first engagement portion is a protruding block disposed on the cylindrical portion, the first coupling portion is disposed on the cylindrical portion, the first elastic valve includes a first annular portion and a first seal portion, both ends of the first annular portion are disposed on the positioning portion and the first coupling portion, respectively, the first seal portion is disposed within the first passage, and a first end of the first seal portion is disposed on the front The needleless connector includes a housing, a second coupling portion, and a second elastic valve, the housing having a second engagement portion, the second engagement portion being a convex block disposed on an outer surface of the housing or an outer surface of the second coupling portion, the first end of the housing having a second opening, the second coupling portion being disposed on a second end of the housing, having a third opening, and being screwed to the screw structure, the third opening being connected to the inner conduit. the second elastic valve includes a second annular portion and a second seal portion, the second annular portion is disposed inside the housing and the second coupling portion and has a second passage, the second passage communicates with the third opening, the third opening communicates with the inner conduit, the second seal portion is disposed inside the housing and has a slit and closes the second opening, and when the movable closure connector is aligned and connected to the needleless connector, the first engagement portion is fixed to the second engagement portion, and the force with which the first engagement portion is fixed to the second engagement portion is 1.4 to 8.the conduit compresses the second seal portion, and the second seal portion compresses the second annular portion, thereby separating the second seal portion from the second opening, the conduit passes through the slit in the second seal portion and enters the inside of the second seal portion, the first end of the housing abuts against an inner wall of the cylindrical portion, the positioning portion moves along the conduit in a direction away from the needleless connector to compress the first annular portion, thereby separating the second end of the first seal portion from the first opening, and When the passage communicates with the inner conduit and the movable closure connector is separated from the needleless connector, the first engagement portion disengages from the second engagement portion and the conduit disengages from the second seal portion, thereby sealing the slit in the second seal portion, the second seal portion returns to its original position due to the elastic force of the second annular portion to close the second opening, the first end of the housing disengages from the tubular portion, and the positioning portion and the first seal portion return to their original position due to the elastic force of the first annular portion, so that the second end of the first seal portion closes the first opening.

[0014] In order to achieve the above object, the present invention provides a separator that is easy to fall off, the separator comprising: a valve body; a threaded structure having an inner conduit, the female thread of a first end of the valve body being threaded into the male thread of the first end of the valve body, the threaded structure being defined as an inlet end of the separator; a discharge end, the first end of which is installed at a second end of the valve body; and an interlocking needleless connector module, the interlocking needleless connector module comprising a movable closure connector and a needleless connector, the movable closure connector comprising a main body, a first coupling part and a first elastic valve, the main body being a cylinder; the first elastic valve includes a first annular portion and a first seal portion, one end of the first annular portion is disposed on the positioning portion, and the first seal portion is disposed within the first passage and has a first end connected to an inner surface of the first annular portion and connected to the first passage. The needleless connector includes a housing, a second coupling portion, a communication pipe, a third elastic valve, and a fourth elastic valve, the housing or the second coupling portion has a second engagement portion, the second engagement portion being a convex block disposed on an outer surface of the housing or an outer surface of the second coupling portion, the first end of the housing has a second opening, the second coupling portion is disposed on a second end of the housing, has a third opening, and is integrally molded with the screw structure, the third opening is communicated with the inner conduit, and the communicating pipe is a third elastic valve. The communication pipe is installed in the housing and includes an upper column body, a large diameter portion, and a lower column body, the upper column body is installed above the large diameter portion, the top end of which is a closed end, and at least one through hole is provided, the at least one through hole penetrates a side wall of the upper column body and communicates with the inside of the upper column body, the lower column body is installed below the large diameter portion, the bottom end of which is an open end, and the inside of the upper column body and the inside of the large diameter portion communicate with the inside of the lower column body, the third elastic valve is installed in the housing, and has a third annular portion and a third seal portion, the third annular portion being:The upper cylinder is provided on the outside of the upper cylinder and has a bottom end that abuts against the large diameter portion, the third seal portion is provided on the top end of the third annular portion and has a slit, the fourth elastic valve is provided in the housing and has a fourth annular portion and a fourth seal portion, the fourth annular portion is provided on the outside of the lower cylinder and has a top end that abuts against the large diameter portion, the fourth seal portion is provided on the bottom end of the fourth annular portion and abuts against an inner wall of the second coupling portion, the second end of the housing presses the top end of the fourth seal portion, and the fourth seal portion has a groove that is aligned with the inside of the lower cylinder and the third opening. a slit is provided between the first and second seal portions, and when the movable closure connector is aligned and connected to the needleless connector, the first engagement portion is fixed to the second engagement portion with a force of 1.4 to 8.1 Newton meters; the upper column expands the slit of the third seal portion and presses it against the first seal portion to compress it, passes through the first opening and enters the inside of the conduit, the conduit compresses the third seal portion, and the third seal portion compresses the third annular portion, thereby closing the at least one perforation of the upper column. The third seal portion is exposed to the outside and positioned inside the conduit, the third annular portion is pressed against the large diameter portion, and the large diameter portion compresses the fourth annular portion, and the lower pillar body widens the slit of the fourth seal portion and enters the third opening, thereby connecting the first passage and the communicating tube to the inner conduit, and when the movable closure connector is separated from the needleless connector, the first engagement portion is released from the second engagement portion, and the fourth annular portion is pressed against the large diameter portion by its elastic force, thereby moving the communicating tube and the third elastic valve, and the lower pillar body is pressed against the fourth annular portion by its elastic force, thereby moving the communicating tube and the third elastic valve, the third annular portion returns to the inside of the annular portion, thereby sealing the slit of the fourth seal portion, the third annular portion presses against the conduit by its elastic force to move a movable closing connector, the upper pillar body detaches from the conduit and returns to the third annular portion, the conduit detaches from the third seal portion, thereby sealing the slit of the third seal portion, the third seal portion returns to its original position by the elastic force of the third annular portion to close the second opening, the first end of the housing detaches from the cylindrical portion, and the first seal portion returns to its original position by its elastic force,The second end of the first seal portion closes the first opening. Effect of the Invention

[0015] The effect of the present invention is that the force with which the first engaging part is fixed to the second engaging part is 1.4 to 8.1 Newton meters (1 to 6 pounds per foot), and they can be easily separated. Even if the patient moves on his / her own, the movable closure connector and the needleless connector can be quickly separated to prevent leakage of medicinal fluid or blood. Also, if they are disinfected with alcohol cotton, they can be used repeatedly without the need for replacement. [Brief description of the drawings]

[0016] [Figure 1] 1 is a schematic diagram of an infusion system according to the present invention. [Diagram 2] FIG. 2 is a cross-sectional exploded view of a first embodiment of the second chemical mixing device according to the present invention. [Diagram 3] FIG. 2 is a cross-sectional exploded view of a second embodiment of a second chemical mixing device according to the present invention. [Figure 4] FIG. 2 is an exploded cross-sectional view of a separator according to the present invention. [Figure 5A] FIG. 2 is a schematic diagram showing drug mixing and infusion in the first embodiment of the second drug mixing device according to the present invention. [Figure 5B] FIG. 5B is a schematic diagram showing region A in FIG. 5A. [Figure 6] FIG. 2 is a schematic diagram showing drug mixing and infusion in the second embodiment of the second drug mixing device according to the present invention. [Figure 7A] FIG. 2 is a schematic diagram of the infusion of a separator according to the present invention. [Figure 7B] FIG. 7B is a schematic diagram showing region B of FIG. 7A. [Figure 8] 1 is a schematic diagram showing another embodiment of the first closed type needleless connector module of the present invention; FIG. [Figure 9A] 1 is a perspective exploded view of a second embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 9B]1 is a cross-sectional exploded view of a second embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 9C] 11 is a cross-sectional view of a second embodiment of the third closed type needleless connector module of the present invention. FIG. [Figure 9D] FIG. 9D is a schematic diagram showing region C in FIG. 9C. [Figure 9E] FIG. 9D is a perspective cross-sectional view of area C in FIG. 9C. [Figure 10A] 13 is a perspective exploded view of a third embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 10B] 11 is a cross-sectional exploded view of a third embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 10C] 11 is a cross-sectional view of a third embodiment of the third closed type needleless connector module of the present invention. FIG. [Figure 10D] FIG. 10D is a schematic diagram showing region D in FIG. 10C. [Figure 11A] FIG. 13 is a perspective view of another application of the syringe and valve body. [Figure 11B] FIG. 13 is a side view of another application of the syringe and valve body. [Figure 12A] FIG. 13 is a cross-sectional view of a syringe and a movable closure connector molded together. [Figure 12B] FIG. 13 is a cross-sectional view of a syringe and another movable closure connector molded together. [Figure 13A] 11 is a perspective view of a fourth embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 13B] 11 is a perspective exploded view of a fourth embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 13C] A cross-sectional view of a fourth embodiment of the third closed type needleless connector module of the present invention. [Figure 13D] 13 is a cross-sectional view of another application of the fourth embodiment of the third closed type needleless connector module of the present invention, in which a syringe provides positive pressure. FIG. [Figure 13E] FIG. 13E is a schematic diagram showing region E in FIG. 13D. [Figure 13F] 11 is a schematic diagram showing the continuous deformation of the balanced pressure valve under the influence of positive pressure in the fourth embodiment of the third closed type needleless connector module of the present invention. FIG. [Figure 13G] 13 is a cross-sectional view of another application of the fourth embodiment of the third closed type needleless connector module of the present invention, in which a balanced pressure valve provides a check function. FIG. [Figure 13H] FIG. 13C is a schematic diagram showing region F of FIG. 13G. [Figure 13I] A cross-sectional view showing another application of the fourth embodiment of the third closed type needleless connector module of the present invention, in which the balance pressure valve loses its check function. [Figure 13J] FIG. 13I is a schematic diagram showing area G in FIG. [Figure 14A] 13 is a perspective view of a fifth embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 14B] 13 is a perspective exploded view of a fifth embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 14C] A cross-sectional view of a fifth embodiment of the third closed type needleless connector module of the present invention. [Figure 14D] FIG. 11 is a cross-sectional view of another application of the fifth embodiment of the third closed type needleless connector module of the present invention, in which a syringe provides positive pressure. [Figure 14E] FIG. 14E is a schematic diagram showing region H in FIG. 14D. [Figure 14F] 13 is a cross-sectional view of another application of the fifth embodiment of the third closed type needleless connector module of the present invention, in which a balanced pressure valve provides a check function. FIG. [Figure 14G] FIG. 14B is a schematic diagram showing region I of FIG. 14F. [Figure 15A] 13 is a perspective view of a sixth embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 15B] 13 is a perspective exploded view of a sixth embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 15C]A cross-sectional view of a sixth embodiment of the third closed type needleless connector module of the present invention. [Figure 16A] 13 is a cross-sectional exploded view of a seventh embodiment of the third closed type needleless connector module of the present invention; FIG. [Figure 16B] A cross-sectional view of the seventh embodiment of the third closed type needleless connector module of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the embodiments of the present invention will be described in more detail with reference to the drawings and reference numerals, so that those skilled in the art can practice the present invention after reading the specification.

[0018] As shown in FIG. 1, the present invention provides an infusion system, which includes a first drug mixing device 10, two second drug mixing devices 20, 20A, three infusion sets 30, 30A, 30B, a distributor 40, a separator 50, and an indwelling needle 60.

[0019] The first chemical mixing device 10, like the second chemical mixing device 20, includes a puncture part 11, a connection part 12, a discharge part 13, and a plug connector 14. With reference to Fig. 2, details of the above configuration will be described below using the second chemical mixing device 20 as an example.

[0020] The first end of the puncturing part 11 is a sharp end, and a side wall of the puncturing part 11 is provided with a U-shaped through hole 111 and three side holes 112. The internal space of the puncturing part 11 is partitioned by a first partition wall 113 into one first long hole 114 and three second long holes 115, and the first long hole 114 communicates with the U-shaped through hole 111, and each of the second long holes 115 communicates with each of the side holes 112.

[0021] Note that distance D1 from the apex of U-shaped through hole 111 to the sharp end of puncturing portion 11 is smaller than distance D2 from the apex of side hole 112 to the sharp end of puncturing portion 11. In other words, the distance between the apex of U-shaped through hole 111 and the sharp end of puncturing portion 11 is close, a U-shaped hole is formed, and the distance between the apex of side hole 112 and the sharp end of puncturing portion 11 is far.

[0022] The connection portion 12 includes a connector coupling seat 121. The connector coupling seat 121 is integrally molded on one side of the second end of the puncture portion 11, and has a first flow passage 1211 communicating with the U-shaped through-hole 111.

[0023] The discharge part 13 is disposed at the second end of the puncture part 11, and is provided with a second flow path 131 and an insertion hole 132, and the second flow path 131 communicates between the second long hole 115 and the insertion hole 132. In this embodiment, the outer surface of the discharge part 13 is a smooth curved surface.

[0024] Between the connection part 12 and the discharge part 13 , the first flow path 1211 and the second flow path 131 are separated by a second partition wall 15 , and the first partition wall 113 is connected to the second partition wall 15 .

[0025] The plug connector 14 has a tube 141. A third flow path 1411 is provided in the tube 141, and a first end of the tube 141 is inserted into the insertion hole 132 so that the second flow path 131 communicates with the third flow path 1411. A blocking portion 1412 is provided inside the third flow path 1411 so as to close the third flow path 1411.

[0026] 1, the connection part 12 of the first chemical mixing device 10 further includes a vial adapter 122. The vial adapter 122 is integrally molded with the connector coupling seat 121, has an insertion needle, and is used for coupling to the vial 100.

[0027] 2 and 5A, the structural difference between the second chemical mixing apparatus 20 and the first chemical mixing apparatus 10 is that the second chemical mixing apparatus 20 further includes a first closed needleless connector module 21 instead of the vial adapter 122. More specifically, the first closed needleless connector module 21 includes a movable closed connector 22 and a first needleless connector 23.

[0028] The movable closing connector 22 includes a main body 221, a first coupling portion 222, and a first elastic valve 223. The main body 221 includes a cylindrical portion 2211, a conduit 2212, a positioning portion 2213, and a first engagement portion 2214. The cylindrical portion 2211 includes an upper cylindrical portion 22111, a middle cylindrical portion 22112, and a lower cylindrical portion 22113. The middle cylindrical portion 22112 is disposed between a first end of the upper cylindrical portion 22111 and a first end of the lower cylindrical portion 22113, a first through hole 22114 is provided between a side wall of the upper cylindrical portion 22111 and a side wall of the middle cylindrical portion 22112, and a second through hole 22115 is provided between a side wall of the middle cylindrical portion 22112 and a side wall of the lower cylindrical portion 22113.

[0029] The conduit 2212 extends from the inside of the upper cylinder portion 22111 to the inside of the middle cylinder portion 22112, and has a first passage 22121 and a first opening 22122. The positioning portion 2213 is located inside the upper cylinder portion 22111 and installed outside the conduit 2212. The first engagement portion 2214 includes an arm portion 22141, a connecting portion 22142, and a hook portion 22143. The connecting portion 22142 is installed in the upper cylinder portion 22111 and is connected to the arm portion 22141 from the inside of the upper cylinder portion 22111 through the first through hole 22114, and the hook portion 22143 is installed at one end of the arm portion 22141 and located in the second through hole 22115. The first coupling portion 222 includes a first end portion 2221, a second end portion 2222, and a communication passage 2223.

[0030] The first end 2221 is disposed at the second end of the upper cylindrical portion 22111 and has a groove 22211 with an arc-shaped wall, and the second end 2222 is a vial adapter having an insertion needle 1221 and used for coupling to a vial 100A (see FIGS. 1 and 5A). The communication passage 2223 passes through the first end 2221 and the second end 2222 and communicates with the groove 22211. The first elastic valve 223 includes a first annular portion 2231 and a first seal portion 2232.

[0031] Both ends of the first annular portion 2231 are respectively disposed at the positioning portion 2213 and the first end portion 2221, and the first sealing portion 2232 is positioned within the first passage 22121. A first end of the first sealing portion 2232 is connected to the inner surface of the first annular portion 2231 and is provided with a number of perforations 2233. The perforations 2233 communicate with the first passage 22121 and the groove 22211, and a second end of the first sealing portion 2232 closes the first opening 22122.

[0032] The first needleless connector 23 includes a housing 231, a second coupling portion 232, and a second elastic valve 233. The housing 231 includes an upper housing 2311, a lower housing 2312, a second engaging portion 2313, and a stabilizing member 2314. A first end of the upper housing 2311 has a second opening 23111, and the outer diameter of the upper housing 2311 is smaller than the outer diameter of the lower housing 2312. The second engaging portion 2313 is a convex block and is installed on the outer surface of the first end of the lower housing 2312.

[0033] The stabilizing member 2314 is a convex block and is installed on the outer surface of the second end of the lower housing 2312. The second coupling portion 232 has a first end 2321 and a second end 2322. The first end 2321 is installed on the second end of the lower housing 2312, and the second end 2322 has a third opening 23222, which is used to couple with the connector coupling seat 121. The second elastic valve 233 has a second annular portion 2331 and a second sealing portion 2332.

[0034] The second annular portion 2331 is disposed inside the lower housing 2312 and the second coupling portion 232 and has a second passage 23311 which communicates with the third opening 23222. The second seal portion 2332 is disposed inside the upper housing 2311 and has a slit 23321 which closes the second opening 23111.

[0035] 5A , referring to FIG. 2 , when the movable closure connector 22 is aligned and connected to the first needleless connector 23, the second engagement portion 2313 is positioned in the second through-hole 22115, and the hook portion 22143 is fixed to the bottom end of the second engagement portion 2313. The conduit 2212 compresses the second sealing portion 2332, and the second sealing portion 2332 compresses the second annular portion 2331, so that the second sealing portion 2332 is separated from the second opening 23111, and the conduit 2212 passes through the slit 23321 and enters the inside of the second sealing portion 2332.

[0036] A first end of the upper housing 2311 abuts against an inner wall of the middle cylinder portion 22112. The positioning portion 2213 moves along the conduit 2212 in a direction away from the first needleless connector 23 to compress the first annular portion 2231, whereby the second end of the first seal portion 2232 is separated from the first opening 22122 and the first passage 22121 communicates with the second passage 23311. Since the inner surface of the lower cylinder portion 22113 abuts against the outer surface of the stabilizing member 2314, the lower housing 2312 does not swing within the lower cylinder portion 22113.

[0037] As shown in FIG. 2, referring to FIG. 5A, when the movable closing connector 22 is separated from the first needleless connector 23, the arm portion 22141 is pressed so that the hook portion 22143 is released from the bottom end of the second engagement portion 2313. The conduit 2212 is released from the second seal portion 2332 to seal the slit 23321. The second seal portion 2332 is restored by the elastic force of the second annular portion 2331 to close the second opening 23111. The first end of the upper housing 2311 is released from the middle tube portion 22112. The positioning portion 2213 and the first seal portion 2232 are restored by the elastic force of the first annular portion 2231 to close the first opening 22122.

[0038] Preferably, the force with which the hook portion 22143 is fixed to the second engagement portion 2313 is 96.14 Newton meters, and the condition for achieving the above force is that the height H1 at which the hook portion 22143 protrudes from the arm portion 22141 is 1.53 to 1.62 mm, as shown in FIG. 5B. Therefore, when a user attempts to remove the movable closing connector 22 by a pulling means, the pulling force must exceed 96.14 Newton meters in order for the hook portion 22143 to be disengaged from the second engagement portion 2313. When a user attempts to remove the movable closing connector 22 by a less labor-intensive means, the hook portion 22143 can be disengaged from the second engagement portion 2313 by pressing the arm portion 22141.

[0039] Due to the above technical features, it is difficult for the hook portion 22143 to be pulled out of the second engagement portion 2313, and it is necessary to press the arm portion 22141 to release the hook portion 22143 from the second engagement portion 2313, so that the following effects can be achieved: First, it can effectively prevent leakage caused by related medical movements such as spontaneous movement or turning over during use. Second, it can effectively prevent separation caused by excessive movement during use, and will not cause liquid leakage or blood reflux. Third, after the movable closure connector 22 and the first needleless connector 23 are separated, they can be disinfected with alcohol and then assembled, which can reduce the time and cost of consumables for medical personnel; Fourth, it is generally applicable to use in normal, independent patients receiving intravenous infusions; Fifth, it can be used to provide medical support to mentally unstable patients and the elderly.

[0040] It is noteworthy that without the above-mentioned technical features, the active closure connector 22 may be easily detached, which may increase the cost of additional medical equipment and medical personnel, increase the risk of bacterial infection for the patient during treatment, and may fail to achieve the expected medical effect, raising concerns about the patient's recovery.

[0041] In some embodiments, the force with which the hook 22143 is fixed to the second engagement portion is less than 96.14 Newton meters. The condition for achieving the above force is that the height H1 of the hook portion 22143 protruding from the arm portion 22141 is less than 1.53 mm. Therefore, when a user tries to remove the movable closure connector 22 by a pulling method, the hook portion 22143 can be disengaged from the second engagement portion 2313 if the pulling force is less than 96.14 Newton meters, and when a user tries to remove the movable closure connector 22 by a less labor-intensive means, the arm portion 22141 can be pressed, and the hook portion 22143 can be disengaged from the second engagement portion 2313. The above technical features provide the effect of being firmly fixed to the first closed needleless connector module 21 but easily removable.

[0042] As shown in FIG. 3 and FIG. 6, the difference between the first closed type needleless connector module 21A and the first closed type needleless connector module 21 is that: The first and second ends 2222 are luer tapers and are used to connect to a syringe 200 (see FIGS. 1 and 6 ); Second, the communication passage 2223 has a large diameter portion 22231 and a small diameter portion 22232; Third, the first elastic valve 223 further includes a plunger 2234, a first end of the plunger 2234 is installed at the first end of the first sealing portion 2232, and a second end of the plunger 2234 has a head 22341, the diameter of which is equal to the diameter of the small diameter portion 22232 and smaller than the diameter of the large diameter portion 22231.

[0043] As shown in Fig. 6, when the movable closure connector 22 is aligned and connected to the first needleless connector 23, the head 22341 is positioned in the large diameter portion 22231 and a gap is formed between the head 22341 and the hole wall of the large diameter portion 22231, so that the communication passage 2223 communicates with the groove 22211. As shown in Fig. 3, when the movable closure connector 22 and the first needleless connector 23 are separated, the head 22341 is positioned in the small diameter portion 22232, but a distance is maintained between the head 22341 and the inner surface of the small diameter portion 22232 to maintain the smoothness of the communication passage 2223. Other than that, the technical features of the second chemical mixing device 20A are exactly the same as those of the second chemical mixing device 20.

[0044] As shown in FIGS. 1 and 5A, the puncturing part 11 of the second chemical mixing device 20A passes through the blocking part 1412 of the second chemical mixing device 20A, so that the second chemical mixing device 20 and the second chemical mixing device 20A are connected in series with each other.

[0045] In some embodiments, multiple second drug mixing devices 20, 20A can be connected to each other by the above-mentioned series connection means, or multiple second drug mixing devices 20 are connected to each other by the above-mentioned series connection means, or multiple second drug mixing devices 20A are connected to each other by the above-mentioned series connection means, all of which are possible embodiments. In some embodiments, the infusion system may only include the second drug mixing device 20 or the second drug mixing device 20A.

[0046] 1, a first end of the infusion set 30 passes through the blocking portion 1412 of the first medicine mixing device 10, thereby connecting the infusion set 30 to the second flow path 131 via the third flow path 1411 of the first medicine mixing device 10. As shown in FIGS. 1 and 6, a first end of the infusion set 30A passes through the blocking portion 1412 of the second medicine mixing device 20A, thereby connecting the infusion set 30A to the second flow path 131 via the third flow path 1411 of the second medicine mixing device 20A.

[0047] As shown in FIG. 1, the distributor 40 includes an accumulating section 41, three injection ends 42, 43, and 44, a discharge end 45, a second closed type needleless connector module 21B, and a screw-on type needleless connector module 46. The injection ends 42, 43, and 44 are connected to a first end of the accumulating section 41. The discharge end 45 is connected to a second end of the accumulating section 41. The difference between the second closed type needleless connector module 21B and the first closed type needleless connector module 21A is that: First, the first elastic valve 223 does not include a plunger 2234; The second end 2222 is connected to a second end of the infusion set 30; and Third, the second end 2322 is adapted to be coupled to the injection end 42 .

[0048] The screw-type needleless connector module 46 includes a screw part and a second needleless connector, the screw part is installed at the second end of the infusion set 30A, the second needleless connector has the same structure as the first needleless connector 23, the upper housing 2311 of the second needleless connector is screwed to the screw part, and the second end 2322 of the second needleless connector is installed at the injection end 43. The injection end 44 is installed at the second end of the infusion set 30B. The second closed type needleless connector module 21B and the first closed type needleless connector module 21A operate in exactly the same way.

[0049] 4, 7A and 7B, the separator 50 includes a valve body 51, a threaded structure 52, a discharge end 53, a third needleless connector 23B and a third closed-type needleless connector module 21C. The valve body 51 is a three-way valve, and the female thread 521 of the threaded structure 52 is threaded into the male thread 511 at the first end of the valve body 51. The threaded structure 52 has an inner conduit 523, the first end of the discharge end 53 is located at the second end of the valve body 51, and the second end 2322 is located at the third end of the valve body 51.

[0050] The difference between the third closed type needleless connector module 21C and the first closed type needleless connector module 21A is that First, the middle cylinder portion 22112 is disposed inside the first end of the upper cylinder portion 22111, and the lower cylinder portion 22113 is disposed outside the first end of the upper cylinder portion 22111, so that the middle cylinder portion 22112 extends into the lower cylinder portion 22113; Second, the conduit 2212 extends from inside the upper cylinder portion 22111 through inside the middle cylinder portion 22112 to inside the lower cylinder portion 22113; Third, the first engagement portion 2214 is a convex block, which is installed on the inner surface of the lower cylinder portion 22113 and positioned below the middle cylinder portion 22112; Fourth, the second end 2322 is installed in the screw structure 52, the first end of the screw structure 52 has a plurality of claws 522 on its outer surface, the second end of the screw structure 52 has a female thread 521, the bottom end of the second end 2322 is a ratchet, and the inner surface of the second end 2322 has a plurality of teeth 23223, and the structure of the third needleless connector 23B is exactly the same as that of the first needleless connector 23; Fifth, the third opening 23222 is connected to the inner conduit 523 .

[0051] As shown in FIG. 7, when the movable closure connector 22 is aligned and connected to the first needleless connector 23, the first engagement portion 2214 is fixed to the bottom end of the second engagement portion 2313, and the force with which the first engagement portion 2214 is fixed to the second engagement portion 2313 is 1.4-8.1 Newton meters (1-6 pounds per foot), and the first passage 22121 and the second passage 23311 communicate with the inner conduit 523. As shown in FIG. 4, when the movable closure connector 22 is separated from the first needleless connector 23, the first engagement portion 2214 is released from the bottom end of the second engagement portion 2313. Other than that, the third closed needleless connector module 21C and the first closed needleless connector module 21A have exactly the same technical features.

[0052] As shown in FIG. 1, the indwelling needle 60 is placed at the second end of the discharge end 53 .

[0053] The following describes how the infusion system performs a drug mixing procedure, which uniformly mixes the concentrated drug solution in the two vials 100, 100A and the syringe 200 with the diluent solution in the two soft bags 300, 300A.

[0054] In step (1), the vials 100, 100A containing an ingredient are taken according to the doctor's instructions, including the powder of the ingredient inside the vials 100, 100A, and the soft bags 300, 300A containing a diluent solution are taken according to the doctor's instructions, which may be saline or glucose solution.

[0055] 1, the vial 100 is fitted to the vial adapter 122 of the first chemical mixing device 10, and the insertion needle 1221 of the first chemical mixing device 10 pierces the cap 110 of the vial 100. As shown in FIG. 5A, the vial 100A is fitted to the second end 2222 of the first closed type needleless connector module 21, and the insertion needle 1221 of the first closed type needleless connector module 21 pierces the cap 110 of the vial 100A.

[0056] As shown in Figures 1 and 5A, the first ends of these puncture parts 11 pierce the membrane of the infusion tube of these soft bags 300, 300A, and the infusion set 30B directly pierces the membrane of the infusion tube of the soft bag 300B.

[0057] In step (1-1), the soft bags 300 and 300A are placed on top, the infusion system is placed on the bottom, and the soft bag 300 is pushed out, so that the dilution solution in the soft bag 300 passes through the U-shaped through hole 111, the first long hole 114, the first flow path 1211, and the insertion needle 1221 of the first medicine mixing device 10, and then enters the inside of the vial 100. The soft bag 300A is placed on top, the infusion system is placed on the bottom, and the soft bag 300A is pushed out, so that the dilution solution in the soft bag 300A passes through the U-shaped through hole 111, the first long hole 114, the first flow path 1211, the third opening 23222, the second passage 23311, the first passage 22121, the perforations 2233, the recessed groove 22211, the communication passage 2223, and the insertion needle 1221 of the second medicine mixing device 20, and then enters the inside of the vial 100A. By shaking the vials 100 and 100A, the powder and diluent solution inside the vials 100 and 100A are mixed slightly to obtain a highly concentrated drug solution.

[0058] In step (2), the soft bags 300 and 300A are placed below and the infusion system is placed above, the soft bag 300 is pushed out, and the air in the soft bag 300 passes through the U-shaped through hole 111, the first long hole 114, the first flow path 1211, and the insertion needle 1221 of the first medicine mixing device 10 in order, and then enters the inside of the vial 100. The soft bag 300A is pushed out, and the air in the soft bag 300A passes through the U-shaped through hole 111, the first long hole 114, the first flow path 1211, the third opening 23222, the second passage 23311, the first passage 22121, the perforations 2233 thereof, the recessed groove 22211, the communication passage 2223, and the insertion needle 1221 of the second medicine mixing device 20 in order, and then enters the inside of the vial 100A.

[0059] In step (3), the soft bag 300 is loosened, and the high-concentration drug solution in the vial 100 passes through the insertion needle 1221, the first flow path 1211, the first long hole 114, and the U-shaped through hole 111 of the first chemical mixing device 10 in order, and then enters the inside of the soft bag 300. As shown in FIG. 5A, the soft bag 300A is loosened, and the high-concentration drug solution in the vial 100A passes through the insertion needle 1221, the communication path 2223, the groove 22211, the perforations 2233 thereof, the first path 22121, the second path 23311, the third opening 23222, the first flow path 1211, the first long hole 114, and the U-shaped through hole 111 of the second chemical mixing device 20 in order, and then enters the inside of the soft bag 300A.

[0060] As shown in FIG. 6, the high concentration drug solution in the syringe 200 passes through the communicating passage 2223, the groove 22211, the perforations 2233 thereof, the first passage 22121, the second passage 23311, the third opening 23222, the first flow path 1211, the first long hole 114, the U-shaped through hole 111, and the third flow path 1411, the second flow path 131, the second long hole 115 thereof, and the side holes 112 thereof of the second drug mixing device 20 in that order, before entering the inside of the soft bag 300A.

[0061] By repeating steps (2) and (3), all of the high-concentration drug solutions in the vials 100, 100A and the syringes 200 can enter the interiors of the soft bags 300, 300A, and the high-concentration drug solutions in the soft bags 300, 300A can be thoroughly mixed with the dilution solution to obtain a diluted drug.

[0062] It is worth noting that during the drug mixing procedure, the distance D1 from the U-shaped through hole 111 to the sharp end of the puncturing part 11 is shorter than the distance D2 from the side hole 112 to the sharp end of the puncturing part 11 (i.e., the distance between the U-shaped through hole 111 and the sharp end of the puncturing part 11 is closer, and the distance between the side hole 112 and the sharp end of the puncturing part 11 is farther). In addition, the larger and longer the diameter of the puncturing part 11 is, the smaller the gap through which the puncturing part 11 is inserted into the infusion tube of the soft bag 300, 300A is, the narrower the flow space is, and tension is generated to prevent the flow of the drug solution, thereby achieving the effect of preventing high-concentration drug solution from entering these side holes 112.

[0063] The following describes how the infusion system performs an infusion procedure, thereby injecting a diluted medication into the patient's body.

[0064] In step (a), as shown in FIG. 1, these soft bags 300, 300A, 300B are placed on top and the infusion system is placed on the bottom, and the diluted drug in the soft bag 300 passes through these side holes 112 of the first drug mixing device 10, these second long holes 115, the second flow path 131, the third flow path 1411, the infusion set 30, the communication passage 2223 of the first closed type needleless connector module 21A, the groove 22211, these perforations 2233, the first passage 22121, the second passage 23311, the third opening 23222, and the injection end 42 in order, and then enters the inside of the accumulation section 41.

[0065] As shown in Figures 1, 5A and 6, the diluted drug in the soft bag 300A passes through the side holes 112, the second long holes 115, the second flow path 131, the third flow path 1411 of the second drug mixing device 20, the side holes 112, the second long holes 115, the second flow path 131, the third flow path 1411 of the second drug mixing device 20A, the infusion set 30A, the screw part 461 of the screw-type needleless connector module 46, the slit 23321 of the needleless connector, the second passage 23311, the third opening 23222, and the injection end 43 in order, and then enters the inside of the collecting section 41. As shown in Figure 1, the other drug in the soft bag 300B passes through the infusion set 30B and the injection end 44 in order, and then enters the inside of the collecting section 41.

[0066] In step (b), as shown in Figures 1 and 7A, the three drugs are mixed inside the accumulation section 41, and then pass through the discharge end 45 and enter the third closed-type needleless connector module 21C.

[0067] In step (c), as shown in Figures 1 and 7A, the mixed drug passes through the communicating passage 2223, the groove 22211, the perforations 2233 thereof, the first passage 22121, the second passage 23311, the third opening 23222, the screw structure 52 of the separator 50, the valve body 51, the discharge end 53, and the indwelling needle 60 in sequence, and then enters the patient's body.

[0068] As a result, the U-shaped through hole 111 and these side holes 112 are separated by the first partition 113, and the first flow path 1211 and the second flow path 131 are separated by the second partition 15, so that in step (3), the high concentration drug solution in the vial 100 only passes through the insertion needle 1221, the first flow path 1211, the first long hole 114 of the puncture portion 11, and the U-shaped through hole 111 in that order of the first chemical mixing device 10, but does not pass through the second flow path 131 of the first chemical mixing device 10, the second long holes 115 of these, and these side holes 112 in that order.

[0069] The high-concentration drug solution in the vial 100A passes through the insertion needle 1221, the communication passage 2223, the groove 22211, the perforations 2233 thereof, the first passage 22121, the second passage 23311, the third opening 23222, the first flow path 1211, the first long hole 114, and the U-shaped through hole 111 of the second chemical mixing device 20 in that order, but does not pass through the second flow path 131, the second long hole 115 thereof, or the side hole 112 thereof in that order. Therefore, in the process of passing through the U-shaped through hole 111 of the first chemical mixing device 10 and the second chemical mixing device 20, the high-concentration drug solution in these vials 100 and 100A does not adhere to the inner walls of the side holes 112 thereof at all.

[0070] When performing step (2) again, since no high-concentration drug solution is attached to the inner walls of these side holes 112, even if the air in these soft bags 300, 300A passes through these side holes 112, no high-concentration drug solution remains in the space between the second flow path 131 and the insertion hole 132.

[0071] Since no high-concentration medicinal liquid remains in the space between the second flow path 131 and the insertion hole 132, when the injection procedure is performed, only the diluted drug can pass through these side holes 112, these second long holes 115, the second flow path 131, the third flow path 1411, the infusion set 30, 30A, the distributor 40, the separator 50, and the indwelling needle 60 in that order, and then enter the patient's body. This means that there is no problem of residual high-concentration medicinal liquid entering the patient's body, the patient does not feel unwell, and the method is safe and reliable.

[0072] Furthermore, since no high-concentration medicinal liquid remains in the space between the second flow path 131 and the insertion hole 132, the nurse does not need to discharge the remaining high-concentration medicinal liquid to the outside, and the amount of drug injected into the patient's body does not decrease, which is in accordance with the doctor's instructions, the therapeutic effect can be maintained, and no drug is wasted.

[0073] In addition, the first long holes 114 allow only the high concentration medicinal liquid in the vials 100, 100A to pass through and enter the soft bags 300, 300A, and these second long holes 115 allow only the diluted drug in the soft bags 300, 300A to pass through and enter the patient's body, thereby preventing the diluted drug from flowing back into the vials 100, 100A, and preventing a reduction in the amount of medicinal liquid injected into the patient's body, thereby conforming to the doctor's instructions, maintaining the therapeutic effect, and not wasting medicine.

[0074] In addition, for the first closed needleless connector module 21, 21A, when the movable closed connector 22 is separated from the first needleless connector 23, both the movable closed connector 22 and the first needleless connector 23 have a closing effect, and leakage of the drug solution can be prevented. Therefore, the vial 100A and the syringe 200 can be removed from the movable closed connector 22, so that the second drug mixing device 20, 20A can be used repeatedly.

[0075] When medical personnel want to mix drugs multiple times, they can use the same second drug mixing device 20, 20A to load multiple vials 100A or multiple syringes 200 multiple times to mix drugs multiple times, and there is no need to replace the second drug mixing device 20, 20A, which can save costs. Of course, medical personnel can also connect multiple second drug mixing devices 20, 20A in series to load multiple vials 100A or multiple syringes 200 at once, and complete the above-mentioned multiple drug mixing procedures at once, saving time. Please note that before loading the vial 100A or syringe 200, the movable closure connector 22 and the first needleless connector 23 must be disinfected first.

[0076] In addition, with regard to the second closed type needleless connector module 21B, when the movable closed type connector 22 is separated from the first needleless connector 23, both the movable closed type connector 22 and the first needleless connector 23 have a closing effect, thereby preventing leakage of the medicinal solution.

[0077] Furthermore, for the third closed type needleless connector module 21C, the force with which the first engagement portion 2214 is fixed to the second engagement portion 2313 is 1.4 to 8.1 Newton meters (1 to 6 pounds per foot), which has the effect of making them easy to separate. Even if the patient moves on his / her own, the movable closed connector 22 and the first needle connector 23 are quickly separated to prevent leakage of medicinal liquid and blood, and can be used repeatedly without the need for replacement if disinfected with alcohol cotton. When the heights H2, H3, and H4 of the first engagement portion 2214 protruding from the lower tube portion 22113 are 0.05 mm, the force with which the first engagement portion 2214 is fixed to the second engagement portion 2313 is 2.7 Newton meters (2 pounds per foot). When the heights H2, H3, and H4 of the first engagement portion 2214 protruding from the lower cylinder portion 22113 are 0.07 mm, the force with which the first engagement portion 2214 is fixed to the second engagement portion 2313 is 4.1 Newton meters.

[0078] When the heights H2, H3, and H4 of the first engagement portion 2214 protruding from the lower cylinder portion 22113 are 0.1 mm, the force with which the first engagement portion 2214 is fixed to the second engagement portion 2313 is 5.4 Newton meters (4 pounds per foot). When the heights H2, H3, and H4 of the first engagement portion 2214 protruding from the lower cylinder portion 22113 are 0.14 mm, the force with which the first engagement portion 2214 is fixed to the second engagement portion 2313 is 8.1 Newton meters (6 pounds per foot).

[0079] What is important is that the groove walls of the grooves 22211 are arc-shaped, so that the medicinal liquid can flow along the arc-shaped groove walls of the grooves 22211 while preventing the generation of vortexes, thereby increasing the flow rate of the medicinal liquid.

[0080] It is noteworthy that the diameter of the groove 22211 is larger than the diameter of the first sealing portion 2232, so that even when the first annular portion 2231 is compressed and deformed and the first sealing portion 2232 approaches the groove 22211, the groove 22211 still remains smoothly aligned with these perforations 2233 and is not affected.

[0081] Additionally, the upper housing 2311 of the third needleless connector 23B is a Luer taper and is used to couple to the syringe 200. This allows medical personnel to take a blood sample from the second end of the valve body 51 through the third needleless connector 23B of the separator 50 or to add a non-toxic general medication.

[0082] In some embodiments, the valve body 51 may be a female luer taper.

[0083] When the first needleless connector 23 is rotated in the first direction by the first rotational force, the first needleless connector 23 sequentially transmits the first rotational force to the screw structure 52 by means of these teeth 23223 and these pawls 522. The screw structure 52 is fixed to the first end of the valve body 51 by being rotated in the first direction by the first rotational force.

[0084] After the screw structure 52 is fixed to the first end of the valve body 51, when the first needleless connector 23 is rotated by the second rotational force along the second direction opposite to the first direction, the first needleless connector 23 causes the second rotational force to be pushed out to the claws 522 through the teeth 23223, so that the claws 522 are compressed and deformed, and are disengaged from the teeth 23223, and the first needleless connector 23 rotates idly along the second direction relative to the screw structure 52. In this case, the screw structure 52 is still fixed to the first end of the valve body 51, and there is no way for the first needleless connector 23 to drive the screw structure 52 to rotate in the second direction.

[0085] After the threaded structure 52 is fixed to the first end of the valve body 51, when the first needleless connector 23 is rotated in the first direction by the third rotational force, the first needleless connector 23 transmits the third rotational force to the claws 522 through the teeth 23223. The third rotational force is greater than the force that the claws 522 can withstand, and the claws 522 are broken, allowing the threaded structure 52 to freely rotate in the first and second directions relative to the first needleless connector 23, and the medicinal liquid in the discharge end 53 can flow smoothly.

[0086] As shown in FIG. 8, the first closed type needleless connector module 21A1 differs from the first closed type needleless connector module 21A in that the length of the lower cylinder portion 22113 is longer.

[0087] As shown in FIGS. 9A and 9B, the difference in structure between the third closed type needleless connector module 21D and the third closed type needleless connector module 21C is that: First, the tubular portion 2211A of the movable closing connector 22A includes only an upper tubular portion 22111A and a lower tubular portion 22113A; The second and second coupling portions 232A are integrally molded with the screw-fitting structure 52; The third and first needleless connectors 23C include a communication pipe 234 which is disposed within the housing and includes an upper pillar 2341, a large diameter portion 2342, and a lower pillar 2343.

[0088] The upper columnar body 2341 is disposed below the large diameter portion 2342, has a closed top end, and is provided with a through hole (not shown) that penetrates the side wall of the upper columnar body 2341 and communicates with the inside of the upper columnar body 2341. The lower columnar body 2343 is disposed below the large diameter portion 2342, and has an open bottom end, such that the inside of the upper columnar body 2341 and the inside of the large diameter portion 2342 communicate with the inside of the lower columnar body 2343. Fourth, the first needleless connector 23C includes a third elastic valve 235, the third elastic valve 235 is installed in the housing 231A, and has a third annular portion 2351 and a third seal portion 2352. The third annular portion 2351 is installed around the outside of the upper pillar 2341, and its bottom end abuts against the large diameter portion 2342, and the third seal portion 2352 is installed at the top end of the third annular portion 2351, and has a slit 2353; Fifth, the first needleless connector 23C includes a fourth elastic valve 236, which is installed in the housing 231A and has a fourth annular portion 2361 and a fourth seal portion 2362. The fourth annular portion 2361 is installed around the outside of the lower pillar body 2343 and its top end abuts against the large diameter portion 2342, and the fourth seal portion 2362 is installed at the bottom end of the fourth annular portion 2361 and abuts against the inner wall of the second coupling portion 232A. The lower housing 2312A presses the top end of the fourth seal portion 2362, and a slit 2363 is provided in the fourth seal portion 2362 in alignment with the inside of the lower pillar body 2343 and the third opening 23222; Sixth, two grooves 22116 are provided in the lower cylinder portion 22113A.

[0089] As shown in FIGS. 9C, 9D, and 9E, the difference in the alignment and connection method between the third closed type needleless connector module 21D and the third closed type needleless connector module 21C is as follows: First, the upper columnar body 2341 widens the slit 2353 of the third seal portion 2352, presses against the upper first seal portion 2232, compresses it, and passes through the first opening 22122 into the inside of the conduit 2212, and the conduit 2212 compresses the third seal portion 2352, and the third seal portion 2352 compresses the third annular portion 2351, thereby exposing the perforation of the upper columnar body 2341 to the outside of the third seal portion 2352 and positioning it inside the conduit 2212; The second and third annular portions 2351 are pressed against the large diameter portion 2342, which compresses the fourth annular portion 2361, and the lower pillar body 2343 widens the slit 2363 of the fourth seal portion 2362 and enters the third opening 23222, thereby connecting the first passage 22121 and the communicating tube 234 to the inner conduit 523.

[0090] As shown in FIGS. 9A and 9B, the difference between the separation methods of the third closed type needleless connector module 21D and the third closed type needleless connector module 21C is as follows: The first and fourth annular portions 2361 press the large diameter portion 2342 by their elastic force, thereby moving the communicating pipe 234 and the third elastic valve 235, and the lower pillar body 2343 returns to the inside of the fourth annular portion 2361, thereby sealing the slit 2363 of the fourth seal portion 2362. The second and third annular portions 2351 are pressed against the conduit 2212 by their elastic force to move the movable closing connector 22A, so that the upper pillar body 2341 is separated from the conduit 2212 and returns to the third annular portion 2351; Third, the conduit 2212 is separated from the third seal portion 2352 to seal the slit 2353 of the third seal portion 2352, and the third seal portion 2352 returns to its original position due to the elastic force of the third annular portion 2351 to close the second opening 23111; Fourth, when the upper housing 2311A is separated from the lower cylinder portion 22113A and the first seal portion 2232 returns to its original position due to its elastic force, the second end of the first seal portion 2232 closes the first opening 22122.

[0091] As shown in FIGS. 10A, 10B, 10C, and 10D, the difference in structure between the third closed type needleless connector module 21E and the third closed type needleless connector module 21D is: First, the first engagement portion 2214A is cut to form a plurality of short arc length convex blocks; Second, the lower cylinder portion 22113B of the movable closure connector 22B does not have a groove.

[0092] In some embodiments, there may be only one first engagement portion 2214A.

[0093] 11A and 11B, in some embodiments, the two movable closure connectors 22 of the first closure type needleless connector module 21A are respectively disposed at one end of the syringe 200 and the first and second ends of the valve body 51, the first needleless connector 23 of the first closure type needleless connector module 21A is disposed at the third end of the valve body 51, the chuck 70 is disposed at one end of one of the first needleless connectors 23, and the piercing head 80 is disposed at one end of the other first needleless connector 23. These embodiments are suitable for an automated liquid dispenser system.

[0094] In some embodiments, as shown in Figures 12A and 12B, each syringe 200 is integrally molded with two types of movable closure connectors 22. Since the syringe 200 and the movable closure connector 22 are integrally molded, the combination of the syringe 200 and the movable closure connector 22 can be mass-produced, which can reduce manufacturing costs, such as reducing resource waste caused by the use of sterile packaging bags and reducing carbon emissions caused by sterilization. Users do not need to assemble additional parts (e.g., applicable to combinations of syringes 200 and movable closure connectors 22 of various milliliter standards) during use, which saves time, is unified, and makes the use operation more convenient.

[0095] In some embodiments, as shown in FIGS. 13A, 13B, and 13C, the difference in structure between the third closed type needleless connector module 21F and the third closed type needleless connector module 21D is: A stabilizing member 2314 is provided on the outer side of the first and second coupling portions 232B. Second, the second engaging portion 2313 is disposed on the outer surface of the second coupling portion 232B; The third, third closed type needleless connector module 21F further includes a balance pressure valve 90 installed between the second end 2322 of the second coupling portion 232B of the first needleless connector 23D and the screw structure 52.

[0096] Preferably, the second end 2322 forms a chamber 23224, and a bowl-shaped groove 524 is formed in the center of the top of the threaded structure 52. The balanced pressure valve 90 is installed in the chamber 23224 and includes a valve body 91 and a fixed part 92. The valve body 91 is semicircular and located in the bowl-shaped groove 524. It has a slit 911 and a bent part 913 on its outer side. The fixed part 92 is disposed around the outer side of the bent part 913 of the valve body 91. The top of the fixed part 92 abuts on the bottom of the second end 2322, the side wall abuts on the inner wall of the chamber 23224, and the bottom abuts on the top of the threaded structure 52.

[0097] 13D, 13E and 13F, the syringe 200 is connected to the first coupling part 222, the long tube 400 is connected to the screw structure 52, and the inner conduit 523 extends into the long tube 400. When the syringe 200 injects the liquid medicine into the human body through the separator 50 and the long tube 400, the syringe 200 provides positive pressure, and the liquid medicine is concentrated in the internal space of the semispherical valve body 91 under the influence of the positive pressure, so that more liquid medicine moves and is stored. When the bent part 913 of the semispherical valve body 91 can no longer withstand the positive pressure, it is driven by the liquid medicine and gradually moves, opening the slit 911, so that the liquid medicine passes through the slit 911 and the inner conduit 523 and enters the long tube 400.

[0098] 13G and 13H, after the syringe 200 is removed from the first coupling part 222, the connecting tube 234, the third elastic valve 235 and the fourth elastic valve 236 are restored to provide negative pressure, and during the process in which the third elastic valve 235 and the fourth elastic valve 236 are restored under the influence of negative pressure, a part of the medicinal liquid originally filled inside the semispherical valve body 91 continues to flow out through the slit 91 toward the discharge end until it is closed to achieve a constant pressure effect. Then, the opening is closed to prevent the backflow of the medicinal liquid and blood.

[0099] As shown in Figures 13I and 13J, when the syringe 200 extracts excess medicinal liquid through the separator 50 and the long tube 400, the syringe 200 provides negative pressure, and the slit 911 is opened under the influence of the negative pressure to allow the excess medicinal liquid to pass through and enter the syringe 200 through the separator 50 without destroying the blood sample during blood collection.

[0100] The balanced pressure valve 90 can prevent backflow of blood even if the medicine bag is dropped during infusion, if the patient coughs, or if the medicine bag becomes lower than the patient's body.

[0101] In some embodiments, as shown in Figures 14A, 14B and 14C, the structural difference between the third closed type needleless connector module 21G and the third closed type needleless connector module 21F is that the check valve 90A replaces the balance pressure valve 90.

[0102] Specifically, an upper chamber 23225 is formed at the second end 2322 of the second coupling portion 232C of the first needleless connector 23E, a lower chamber 525 is formed at the screw structure 52, and the check valve 90A includes a valve body 91A, a fixed portion 92A, and a stopper 93. The valve body 91A is located in the lower chamber 525 and has a through hole 912. The top of the fixed portion 92 abuts against the bottom of the second end 2322, the side wall abuts against the inner wall of the lower chamber 525, and the bottom abuts against the top of the screw structure 52. The stopper 93 is installed in the upper chamber 23225.

[0103] 14D and 14E , the syringe 200 is connected to the first coupling part 222, the long tube 400 is connected to the screw structure 52, and the inner conduit 523 extends into the long tube 400. When the syringe 200 injects a liquid medicine into the human body through the separator 50 and the long tube 400, the syringe 200 provides a positive pressure, and the valve body 91A is influenced by the positive pressure and is separated from the stopper 93, so that the stopper 93 no longer closes the through hole 912, and the liquid medicine passes through the through hole 912 and the inner conduit 523 and enters the long tube 400.

[0104] As shown in Figures 14F and 14G, after the syringe 200 is removed from the first connecting part 222, the communicating tube 234, the third elastic valve 235 and the fourth elastic valve 236 return to their original positions to provide negative pressure, and the valve body 91A abuts against the stopper 93 under the influence of the negative pressure, and the stopper 93 closes the through hole 912 to prevent backflow of the medicinal solution and blood.

[0105] As shown in FIGS. 15A, 15B, and 15C, the difference in structure between the third closed type needleless connector module 21H and the third closed type needleless connector module 21F is that The housing 231A and the second coupling portion 232B of the first needleless connector 23F are integrally molded; The outer wall of the second and second coupling parts 232B has a plurality of anti-slip ribs 2323 to prevent the user from making an operation mistake. a block 2324 in which a third opening 23222 is provided is provided inside the second end 2322 of the third and second coupling portion 232B; Fourth, a lower chamber 525 is formed in the screw-type structure 52, the valve body 91 is located in the lower chamber 525, the top of the fixing part 92 abuts against the bottom of the block 2324, the side wall abuts against the inner wall of the lower chamber 525, and the bottom abuts against the top of the screw-type structure 52.

[0106] In some embodiments, the balanced pressure valve 90 of the third closed needleless connector module 21H can be replaced by a check valve 90A.

[0107] In some embodiments, the check valve 90A replaces the balanced pressure valve 90. Specifically, the threaded structure 52 defines a lower chamber 525, and the check valve 90A includes a valve body 91A, a fixing portion 92A, and a stopper 93. The valve body 91A is located in the lower chamber 525 and has a through hole 912. The stopper 93 is integrally molded with the block 2324.

[0108] 16A, the difference between the structure of the movable closure connector 22C of the third closing type needleless connector module 21I and the structure of the movable closure connector 22B of the third closing type needleless connector module 21E is that the first engagement part 2214A can be located at the bottom near the lower cylinder part 22113C of the movable closure connector 22C. In other words, the first engagement part can be located at any position of the lower cylinder part of the movable closure connector.

[0109] 16A, the difference between the structure of the first needleless connector 23G of the third closed type needleless connector module 21I and the structure of the first needleless connector 23F of the third closed type needleless connector module 21H is that the first needleless connector 23G includes a communication tube 234A and a fifth elastic valve 237. The communication tube 234A is installed in the second connecting part 232B, has a cone shape, has a closed top end, and is provided with a through hole (not shown), which penetrates the side wall of the communication tube 234A and communicates with the inside of the communication tube 234A, and the bottom end of the communication tube 234A is the block 2324. The fifth elastic valve 237 is installed in the second connecting part 232B, and has a fifth annular portion 2371 and a fifth sealing portion 2372.

[0110] As shown in Figure 16B, the difference in the alignment connection method between the third closed type needleless connector module 21E and the third closed type needleless connector module 21F is that the communicating tube 234A widens the slit 2373 (see Figure 16A) of the fifth sealing portion 2372, presses against and compresses the first sealing portion 2232, and when it passes through the first opening 22122 and enters the inside of the conduit 2212, the conduit 2212 compresses the fifth sealing portion 2372 and the fifth annular portion 2371 is not deformed.

[0111] It is noteworthy that the communicating tube 234 of the first needleless connectors 23C to 23F is movable, and the communicating tube 234A of the first needleless connector 23G is fixed. In other words, any form of movable closure connector 22A, 22B, 22C is applicable to the movable or fixed communicating tubes 234, 234A of the first needleless connectors 23C to 23G.

[0112] In the present invention, the term "medical device" is used to refer to any medical device commonly used in the medical field and may be used to connect or couple with any of the different forms of embodiments other than the connectors disclosed in the present invention, as well as other connector devices related to medical applications.

[0113] The above is intended to illustrate the preferred embodiments of the present invention, and is not intended to limit the present invention in any form. Any modifications or changes made to the present invention under the same inventive concept shall be included in the intended scope of protection of the present invention. [Explanation of symbols]

[0114] 10 First chemical mixing device 11 Puncture site 111 U-shaped through hole 112 Side hole 113 1st bulkhead 114 1st long hole 115 2nd long hole 12 Connection 121 Connector joint 1211 First Channel 122 Vial Adapter 1221 Insertion needle 13 Discharge section 131 Second Channel 132 Insertion hole 14 Plug Connector 141 Body 1411 3rd Stream 1412 Breaker 15 Second bulkhead 20, 20A Second chemical mixing device 21, 21A, 21A1 1st Closed Needleless Connector Module 21B 2nd Closed Needleless Connector Module 21C, 21D, 21E, 21F, 21G, 21H, 21I 3rd Closed Needleless Connector Module 22, 22A, 22B, 22C Movable closure connectors 221 Main unit 2211, 2211A cylinder part 22111, 22111A Upper cylinder part 22112 Middle cylinder part 22113, 22113A, 22113B, 22113C Lower cylinder part 22114 First through hole 22115 Second through hole 22116 Groove 2212 Conduit 22121 1st aisle 22122 First opening 2213 Positioning part 2214, 2214A 1st engagement part 22141 Arm part 22142 Connecting part 22143 Hook part 222 1st joint 2221 First end 22211 Groove 2222 Second end 2223 Communication path 22231 Large diameter section 22232 Small diameter section 223 First Elastic Valve 2231 1st ring circumferential part 2232 First seal part 2233 Perforation 2234 Plunger 22341 Head 23, 23C, 23D, 23E, 23F, 23G 1st needleless connector 23B 3rd Needleless Connector 231, 231A Housing 2311, 2311A Upper housing 23111 Second opening 2312, 2312A Lower Housing 2313 Second engagement part 2314 Stabilizing member 232, 232A, 232B, 232C 2nd joint 2321 First end 2322 Second end 23222 3rd opening 23223 Teeth 23224 Chamber 23225 Upper chamber 2323 Anti-slip rib 2324 Block 233 Second elastic valve 2331 Second ring part 23311 2nd aisle 2332 Second seal part 23321 Slit 234, 234A communication pipe 2341 Upper columnar body 2342 Large diameter section 2343 Lower column 235 Third Elastic Valve 2351 Third ring part 2352 3rd seal part 2353 Slit 236 Fourth Elastic Valve 2361 4th ring part 2362 4th Seal Part 2363 Slit 237 5th Elastic Valve 2371 Fifth ring part 2372 5th Seal Section 2373 Slit 30, 30A, 30B Infusion Set 40 distributor 41 Accumulation section 42, 43, 44 Injection end 45 Discharge end 46 Screw-on needleless connector module 50 Separator 51 Valve body 511 Male thread 52 Screw structure 521 Female screw 522 Claws 523 Internal conduit 524 Bowl-shaped groove 525 Lower Chamber 53 Discharge end 60 Indwelling needle 70 Chuck 80 Piercing Head 90 Balanced Pressure Valve 90A Check valve 91, 91A Valve body 911 Slit 912 Through hole 913 Bend section 92, 92A fixed part 93 Stopper 100, 100A vials 110 Cap 200 syringe 300, 300A, 300B Soft Bag 400 long tube D1, D2 distance H1, H2, H3, H4 Length

Claims

1. A separator that is prone to falling off, A valve body, a threaded structure having an inner conduit, the threaded structure being defined as an injection end of the separator, the threaded structure being threadedly connected to the threaded portion of the first end of the valve body; a discharge end having a first end disposed at the second end of the valve body; a mating needleless connector module; The mating needleless connector module includes a movable closure connector and a needleless connector; The movable closing connector comprises a main body, a first coupling portion, and a first elastic valve, the main body comprises a cylindrical portion, a conduit, a positioning portion, and a first engaging portion, the conduit is disposed inside the cylindrical portion and has a first passage and a first opening, the positioning portion is located inside the cylindrical portion and disposed outside the conduit, the first engaging portion is a convex block disposed on the cylindrical portion, the first coupling portion is disposed on the cylindrical portion, the first elastic valve comprises a first annular portion and a first sealing portion, both ends of the first annular portion are disposed on the positioning portion and the first coupling portion, respectively, the first sealing portion is disposed within the first passage, a first end of the first sealing portion is connected to an inner surface of the first annular portion, and a plurality of perforations communicating with the first passage are provided, and a second end of the first sealing portion closes the first opening, the needleless connector comprises a housing, a second coupling portion, and a second elastic valve, the housing has a second engagement portion, the second engagement portion being a convex block disposed on an outer surface of the housing or an outer surface of the second coupling portion, a first end of the housing has a second opening, the second coupling portion is disposed on a second end of the housing, has a third opening, and is screwed to the screw structure, the third opening is connected to the inner conduit, the second elastic valve comprises a second annular portion and a second seal portion, the second annular portion is disposed inside the housing and the second coupling portion, has a second passage, the second passage is connected to the third opening, the third opening is connected to the inner conduit, the second seal portion is disposed inside the housing, has a slit, and closes the second opening, when the movable closure connector is aligned and connected to the needleless connector, the first engagement portion is fixed to the second engagement portion, a force with which the first engagement portion is fixed to the second engagement portion is 1.4 to 8.1 Newton meters, the conduit compresses the second seal portion, and the second seal portion compresses the second annular portion, thereby separating the second seal portion from the second opening, the conduit passes through the slit in the second seal portion and enters the inside of the second seal portion, the first end of the housing abuts against an inner wall of the cylindrical portion, the positioning portion moves along the conduit in a direction away from the needleless connector to compress the first annular portion, thereby separating the second end of the first seal portion from the first opening, and the first passage and the second passage communicate with the inner conduit, When the movable closure connector is separated from the needleless connector, the first engagement portion disengages from the second engagement portion and the conduit disengages from the second seal portion, thereby sealing the slit in the second seal portion, the second seal portion returns to its original position due to the elastic force of the second annular portion to close the second opening, the first end of the housing disengages from the tubular portion, and the positioning portion and the first seal portion return to their original position due to the elastic force of the first annular portion, so that the second end of the first seal portion closes the first opening. Separator that is prone to falling off.

2. The cylindrical portion includes an upper cylindrical portion, a middle cylindrical portion, and a lower cylindrical portion, The middle cylinder portion is disposed inside the first end of the upper cylinder portion, and the lower cylinder portion is disposed outside the first end of the upper cylinder portion, so that the middle cylinder portion extends into the lower cylinder portion, the conduit extends from an interior of the upper tubular portion through an interior of the middle tubular portion to an interior of the lower tubular portion, the positioning portion is positioned within the upper tubular portion, the first engaging portion is provided on an inner surface of the lower tubular portion and is positioned below the middle tubular portion, and the first connecting portion is provided at a second end of the upper tubular portion, The housing includes an upper housing and a lower housing, a first end of the upper housing has the second opening, an outer diameter of the upper housing is smaller than an outer diameter of the lower housing, and the second engagement portion is installed on an outer surface of the first end of the lower housing; When the movable closure connector is aligned and connected to the needleless connector, the first engagement portion is fixed to a bottom end of the second engagement portion, and a first end of the upper housing abuts against an inner wall of the center tube portion. The separator according to claim 1 which is prone to falling off.

3. When the height of the first engagement portion protruding from the lower cylinder portion is 0.05 mm, the force with which the first engagement portion is fixed to the second engagement portion is 2.7 Newton meters; When the height of the first engagement portion protruding from the lower cylinder portion is 0.07 mm, the force with which the first engagement portion is fixed to the second engagement portion is 4.1 Newton meters; When the height of the first engagement portion protruding from the lower cylinder portion is 0.1 mm, the force with which the first engagement portion is fixed to the second engagement portion is 5.4 Newton meters; When the height of the first engagement portion protruding from the lower cylinder portion is 0.14 mm, the force with which the first engagement portion is fixed to the second engagement portion is 8.1 Newton meters. A separator susceptible to detachment according to claim 2.

4. Further comprising a pressure balancing valve disposed between the second coupling portion and the screw structure. The separator according to claim 1 which is prone to falling off.

5. Further comprising a check valve disposed between the second coupling portion and the screw structure. The separator according to claim 1 which is prone to falling off.

6. A separator that is prone to falling off, A valve body, a threaded structure having an inner conduit, the threaded structure being defined as an injection end of the separator, the threaded structure being threadedly connected to the threaded portion of the first end of the valve body; a discharge end having a first end disposed at the second end of the valve body; a mating needleless connector module; The mating needleless connector module includes a movable closure connector and a needleless connector; The movable closing connector comprises a main body, a first coupling portion, and a first elastic valve, the main body comprises a cylindrical portion, a conduit, a positioning portion, and a first engaging portion, the conduit is disposed inside the cylindrical portion and has a first passage and a first opening, the positioning portion is located inside the cylindrical portion and disposed outside the conduit, the first engaging portion is a convex block disposed on the cylindrical portion, the first coupling portion is disposed on the cylindrical portion, the first elastic valve comprises a first annular portion and a first sealing portion, one end of the first annular portion is disposed on the positioning portion, the first sealing portion is disposed within the first passage, a first end of the first annular portion is connected to an inner surface of the first annular portion, and a plurality of perforations communicating with the first passage are provided, and a second end of the first sealing portion closes the first opening, the needleless connector comprises a housing, a second coupling part, a communicating tube, a third elastic valve, and a fourth elastic valve, the housing or the second coupling part has a second engaging part, the second engaging part being a convex block and installed on an outer surface of the housing or an outer surface of the second coupling part, a first end of the housing has a second opening, the second coupling part is installed on a second end of the housing and has a third opening, and is integrally molded with the screw structure, the third opening is connected to the inner conduit, the communicating tube is installed within the housing, and comprises an upper column body, a large diameter part, and a lower column body, the upper column body is installed above the large diameter part, its top end is a closed end, and at least one through hole is provided, the at least one through hole penetrates a side wall of the upper column body and communicates with the inside of the upper column body, the lower column body is disposed on the large diameter part the third elastic valve is installed in the housing and has a third annular portion and a third seal portion, the third annular portion is installed around the outside of the upper column and its bottom end abuts the large diameter portion, the third seal portion is installed at the top end of the third annular portion and has a slit; the fourth elastic valve is installed in the housing and has a fourth annular portion and a fourth seal portion, the fourth annular portion is installed around the outside of the lower column and its top end abuts the large diameter portion, the fourth seal portion is installed at the bottom end of the fourth annular portion and abuts the inner wall of the second coupling portion, the second end of the housing presses the top end of the fourth seal portion, and the fourth seal portion has a slit aligned with the inside of the lower column and the third opening; When the movable closure connector is aligned and connected to the needleless connector, the first engagement portion is fixed to the second engagement portion, and a force for fixing the first engagement portion to the second engagement portion is 1.4 to 8.1 Newton meters; the upper pillar expands the slit of the third seal portion and presses and compresses it against the first seal portion, passing through the first opening and entering the inside of the conduit, the conduit compresses the third seal portion, the third seal portion compresses the third annular portion to expose the at least one perforation of the upper pillar to the outside of the third seal portion and position it inside the conduit, the third annular portion presses against the large diameter portion, and the large diameter portion compresses the fourth annular portion, and the lower pillar expands the slit of the fourth seal portion and enters the third opening, thereby connecting the first passage and the communication tube to the inner conduit, When the movable closure connector is separated from the needleless connector, the first engagement portion disengages from the second engagement portion, the fourth annular portion is pressed against the large diameter portion by its elastic force, thereby moving the communicating tube and the third elastic valve, the lower pillar body returns to the inside of the fourth annular portion, thereby sealing the slit of the fourth seal portion, the third annular portion is pressed against the conduit by its elastic force, thereby moving the movable closure connector, the upper pillar body disengages from the conduit and returns to the third annular portion, the conduit is disengaged from the third seal portion, thereby sealing the slit of the third seal portion, the third seal portion returns to its original position by the elastic force of the third annular portion, thereby closing the second opening, the first end of the housing disengages from the cylindrical portion, and the first seal portion returns to its original position by its elastic force, thereby closing the second opening. Separator that is prone to falling off.

7. The cylindrical portion includes an upper cylindrical portion and a lower cylindrical portion, the lower tube portion is disposed on the outside of a first end of the upper tube portion, the conduit extends from the inside of the upper tube portion to the inside of the lower tube portion, the positioning portion is located inside the upper tube portion, the first engaging portion is disposed on an inner surface of the lower tube portion, and the first connecting portion is disposed at a second end of the upper tube portion; The housing includes an upper housing and a lower housing, a first end of the upper housing has the second opening, the lower housing presses a top end of the fourth seal portion, and the second engagement portion is installed on an outer surface of the first end of the lower housing; When the movable closure connector is aligned and connected to the needleless connector, the first engagement portion is fixed to a bottom end of the second engagement portion. The separator according to claim 6 which is prone to falling off.

8. When the height of the first engagement portion protruding from the lower cylinder portion is 0.05 mm, the force with which the first engagement portion is fixed to the second engagement portion is 2.7 Newton meters; When the height of the first engagement portion protruding from the lower cylinder portion is 0.07 mm, the force with which the first engagement portion is fixed to the second engagement portion is 4.1 Newton meters; When the height of the first engagement portion protruding from the lower cylinder portion is 0.1 mm, the force with which the first engagement portion is fixed to the second engagement portion is 5.4 Newton meters; When the height of the first engagement portion protruding from the lower cylinder portion is 0.14 mm, the force with which the first engagement portion is fixed to the second engagement portion is 8.1 Newton meters. A separator susceptible to detachment according to claim 7.

9. Further comprising a pressure balancing valve disposed between the second coupling portion and the screw structure. The separator according to claim 6 which is prone to falling off.

10. Further comprising a check valve disposed between the second coupling portion and the screw structure. The separator according to claim 6 which is prone to falling off.

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