Blood vessel wall reinforcer

Abstract

To provide a blood vessel reinforcer.SOLUTION: The following agents are prepared: a blood vessel wall reinforcer that contains soybean protein and / or Tamogitake (Pleurotus citrinopileatus) extract as an active ingredient; a pericyte proliferation promoter that contains soybean protein and / or Tamogitake extract as an active ingredient; and an agent for improving dull skin or dark circles under the eyes that contains soybean protein and / or Tamogitake extract as an active ingredient. Furthermore, a blood vessel wall reinforcer that contains soybean protein and / or ergothioneine is prepared.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a vascular wall strengthening agent and a vascular wall strengthening product. [Background technology]

[0002] In blood vessels, vascular wall cells such as pericytes are present on the basement membrane side of endothelial cells. They have an adhesive structure. They exist as if they surround or line the vascular endothelial cells. Blood vessels with a reduced number of pericytes are structurally unstable and fragile, making it difficult to transport substances between blood and tissues. This can lead to a decrease in the ability to control vascular permeability and poor blood flow. A vascular wall strengthening agent containing as a component thereof is known that increases the number of blood vessels covered by vascular wall cells. (Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2017 / 061559 Summary of the Invention [Problem to be solved by the invention]

[0004] The present invention relates to a vascular The object of the present invention is to provide a wall reinforcement agent. [Means for solving the problem]

[0005] The present inventors have found that a composition containing soy protein and / or ergothioneine has an anti-inflammatory effect on the vascular wall. It was found that soy protein has a reinforcing effect and significantly promotes the strengthening of blood vessel walls. / or Ergothioneine improves skin tone (blood flow, dark circles under the eyes, dull skin) The present invention has been completed based on these findings.

[0006] That is, the present invention provides [1] A substance that contains soy protein and / or ergothioneine as active ingredients to strengthen blood vessel walls. Agent; [2] The vascular wall strengthening agent according to [1], wherein the soy protein is a soy protein hydrolysate; [3] The vascular wall strengthening agent according to [1], which contains ergothioneine as an extract of Pleurotus cornucopiae; [4] The method for strengthening a vascular wall according to any one of [1] to [3], wherein the vascular wall strengthening agent is a pericyte proliferation promoter. Chemical agent; [5] A skin tonic containing soy protein and / or ergothioneine as active ingredients. enhancer; [6] The skin tone improving agent according to [5], wherein the soy protein is a soy protein hydrolysate. ; [7] The skin tone improving agent according to [5], which contains ergothioneine as an extract of Tamogitake mushroom. Superficial agent; [8] The skin tone improving agent is a blood flow improving agent and / or an eye dark circle improving agent. 7] A skin tone improver as described above; [9] Pericyte, containing soy protein and / or ergothioneine as active ingredients Cosmetic compositions for promoting proliferation;

[10] The pericyte proliferation promoting agent according to [9], wherein the soy protein is a soy protein hydrolysate. Advanced beauty composition;

[11] The pericyte increase method described in [9], which contains ergothioneine as an extract of Tamogitake mushroom. Cosmetic composition for promoting growth;

[12] The method for increasing pericytes according to [9] to

[11] , which is used for improving skin tone. Cosmetic composition for promoting growth;

[13] Perisa, characterized by using soy protein and / or ergothioneine. Methods for promoting thrombocytopenic acid proliferation;

[14] Perisa, characterized by using soy protein and / or ergothioneine. Manufacturing method of thief growth promoter;

[15] Perisa, characterized by using soy protein and / or ergothioneine. A method for producing a cosmetic composition for promoting mites proliferation;

[16] The method for the proliferation of pericytes according to

[15] , wherein the soy protein is a soy protein hydrolysate. Method for producing a cosmetic composition for promotion;

[17] The pericyte according to

[15] , which contains ergothioneine as an extract of Tamogitake mushroom. Method for producing a cosmetic composition for promoting proliferation;

[18] A composition containing soy protein and / or ergothioneine is applied to the skin, A cosmetic method for improving and / or preventing conditions caused by loss of pericytes (however, the method is not intended to be used for treating human diseases) (excluding methods of treating etc. Effect of the Invention

[0007] Since the vascular wall strengthening agent of the present invention contains soy protein and / or ergothioneine, The vascular wall strengthening agent of the present invention can promote the strengthening of the vascular wall. / or ergothioneine, which is effective against skin conditions caused by loss of pericytes (poor blood flow) It is also excellent for improving and / or preventing dark circles under the eyes, dull skin, etc. [Brief description of the drawings]

[0008] [Figure 1] 4 shows the results of improvement of dark circles under the eyes in Test Example 2. [Diagram 2] 4 shows the results of improvement of dark circles under the eyes in Test Example 2. [Diagram 3] 1 shows the results of blood flow improvement in Test Example 3. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] Hereinafter, the embodiment of the present invention will be described in detail. The present invention is not limited to the embodiments.

[0010] [1. Vascular wall strengthening agents] The vascular wall strengthening agent according to the present embodiment contains soy protein and / or ergothioneine. do.

[0011] Vascular wall cells adhere to or line endothelial cells from the basement membrane side, surrounding them. Pericytes adhere to the blood vessel walls, stabilizing the structure of the blood vessels and strengthening the blood vessels. As cells, they stabilize the structure of capillaries and venules by contracting and relaxing the capillaries. The blood flow is strengthened and can be adjusted appropriately. In blood vessels with a reduced number of pericytes, blood flow is stagnant, causing congestion. It is believed that poor circulation leads to angiogenesis, which causes blood vessels to expand. In this condition, the amount of reduced hemoglobin, which is blue to purple-red in color, increases. In areas where the skin is thin or has little collagen or elastin, the color of the blood vessels is not visible. In areas where it is easily visible, the skin appears darker than normal. This weakening of the vascular structure can cause the skin to appear dull and dark circles under the eyes. Therefore, the blood vessel wall strengthening agent of the present invention is By increasing pericytes, which are cells that strengthen structures such as capillaries, blood vessels This improves the mobility of the blood vessels, suppresses expansion and thickening, improves blood flow, and improves the amount of reduced hemoglobin. It is said that it improves dark circles under the eyes and dull skin, and has the effect of improving skin tone. can.

[0012] The soy protein in the vascular wall strengthening agent according to this embodiment is derived from soybeans of the legume family. There is no particular limitation, and one or more species of soybean plants may be selected for use. Any part of the plant may be used, and one or more parts may be selected and used. The method for extracting soybean protein and the extraction solvent are not particularly limited, and known techniques can be used. The extract may be used as it is, or may be dried into powder or granules. Alternatively, a decomposition product obtained by treating the extract using a known technique such as enzymatic decomposition may be used. or an enzymatic decomposition product, more preferably trypsin, papain, thermolysin, chymotrypsin, The hydrolysis product is a proteolytic enzyme digestion product such as liposin, and the hydrolysis product is particularly preferably a thermolysin digestion product. Soybean protein can be obtained by a known method, and commercially available soybean protein may be used. The content of soy protein in the vascular wall strengthening agent according to the embodiment has a vascular wall strengthening effect. There are no particular limitations as long as the range is within the range, and the type and content of other ingredients and the formulation form of the vascular wall strengthening agent may also be used. From the viewpoint of more prominently exhibiting the effects of the present invention, for example, It is preferably 0.00001 to 2% by mass, and more preferably 0.0001 to 1.6% by mass. More preferably, the content is 0.0005 to 1.2 mass%, and even more preferably, the content is 0.001 to 1.2 mass%. The dosage for humans is 0.001 to 10% by mass per day. It is preferably 0 mg, more preferably 0.01 to 80 mg, and more preferably 0.1 to It is more preferably 60 mg, and more preferably 1 to 50 mg.

[0013] The ergothioneine in the vascular wall strengthening agent according to the present embodiment is extracted, separated, It may be a purified product or a product obtained by chemical synthesis. Its salts and isomers may also be used. Ergothioneine may also be included as an extract of basidiomycetes. Preferably, it is an extract of Basidiomycetes of the Pleurotus family, and more preferably, it is an extract of Pleurotus cornucopiae. , one selected from the group consisting of oyster mushroom extract, king oyster mushroom extract, and enoki mushroom extract The above is the most preferred, and a Tamogitake extract is also preferred. Commercially available products can also be used. The content of ergothioneine in the vascular wall strengthening agent according to the embodiment has a vascular wall strengthening effect. There are no particular limitations as long as the range is within the range, and the types and contents of other ingredients, the formulation of the vascular wall strengthening agent, etc. From the viewpoint of more significantly exhibiting the effects of the present invention, for example, , 0.0000000015 to 0.00015 mass%, preferably 0.000 It is more preferable that the content is 0.000000 to 0.000015% by mass, and 0.0000000 It is more preferable that the content is 75 to 0.0000075 mass%, and more preferably 0.00000015 to 0 It is particularly preferable that the dosage for humans is 0.0000015% by weight per day. It is preferably 0.001 to 100 mg, and more preferably 0.01 to 80 mg. The amount is preferably 0.1 to 60 mg, more preferably 1 to 50 mg. The content of the extract of Basidiomycetes of the Pleurotus family in the vascular wall strengthening agent according to this embodiment is There are no particular limitations as long as the amount is within a range that has a vascular wall strengthening effect. The amount is appropriately set depending on the formulation form of the vessel wall strengthening agent. The effect of the present invention is more pronounced. From the viewpoint of the above, for example, the content is preferably 0.01 to 0.001 mass%, and more preferably 0.001 to 0 It is more preferably 0.0001% by mass, and more preferably 0.0005 to 0.00005% by mass. It is more preferable that the content is 0.0001 to 0.00001 mass %, and particularly preferable that the content is 0.0001 to 0.00001 mass %. The dosage for humans is 0.000000015-0.0015 mg per day. It is preferable that the amount of the ion exchange resin is 0.00000015 to 0.0012 mg, and more preferable that the amount of the ion exchange resin is 0.00000015 to 0.0012 mg. It is more preferable that the amount is 0.0000015 to 0.0009 mg, and more preferably 0.000015 to 0 Preferably it is .00075 mg.

[0014] The ratio of ergothyme to 100 parts by mass of soy protein in the vascular wall strengthening agent according to this embodiment is The mass parts of Onein are not particularly limited, but from the viewpoint of more significantly exhibiting the effects of the present invention, Therefore, for example, it is preferably 0.0001 to 10, and more preferably 0.001 to 20. More preferably, it is 0.005 to 25, and even more preferably, it is 0.01 to 50. is particularly preferred. The mass part of the extract of the basidiomycete fungus of the Pleurotus family is not particularly limited, but it is preferably as long as the effect of the present invention is achieved. From the viewpoint of exhibiting a more remarkable effect, for example, the ratio is preferably 0.000001 to 0.5. It is more preferable that the range is 0.00001 to 0.1, and more preferably 0.00005 to 0.05. It is more preferable that the ratio is 0.0001 to 0.01, and particularly preferable that the ratio is 0.0001 to 0.01.

[0015] The vascular wall strengthening agent of the present invention is effective in preventing the loss of pericytes, which is the cause of dark circles under the eyes, dull skin, and poor blood flow. It is expected that this will have the effect of preventing and / or improving the conditions caused by pericytes. As a result, the vascular structure becomes fragile, leading to decreased vascular permeability, poor blood flow, and changes in blood composition. These may affect the appearance of the body, particularly in the face, neck, and hands, which become more prone to aging. Areas where the appearance is easily affected by changes in appearance, or where blood vessels are not visible due to thin skin Effective in preventing and / or improving dark circles under the eyes, dull skin, poor blood circulation, etc. in areas prone to blemishes. It is expected to be particularly effective in preventing and / or improving dark circles under the eyes.

[0016] The vascular wall strengthening agent according to the present embodiment may further contain an excipient, a thickener, a binder, a disintegrant, a dispersant, a boundary agent, Surfactants, suspending agents, emulsifiers, stabilizers, gelling agents, sweeteners, sour agents, umami agents, salty agents, bitter agents Flavoring agents, coloring agents, UV protection agents, antioxidants, preservatives, antibacterial agents, pH adjusters, buffers, Additives such as vitamins, fragrances, minerals, amino acids or their salts, sugars, moisturizers, Even if it contains organic acids or their salts, dietary fiber, biological extracts (excluding plant extracts), etc. These can be appropriately selected from known materials and can be produced by conventional methods. .

[0017] The dosage form of the vascular wall strengthening agent according to the present embodiment is not limited to a specific product or properties. The composition may be administered in the form of a liquid, gel, cream, paste, solid, aerosol or patch. The composition can be appropriately prepared in any of the above dosage forms by known methods. Examples include emulsions, beauty essences, oral liquids, and syrups. In solid form, they come in sticks, tablets, Examples include chewable tablets, granules, powders, capsules, and ointments. The composition may be either an external preparation or an internal preparation, but from the viewpoint of achieving the effects of the present invention, it is preferable to use an external preparation. It is preferable that the external preparation be a pharmaceutical or cosmetic product. It can be produced using the method.

[0018] [2. Cosmetic composition for strengthening blood vessel walls] The cosmetic product according to this embodiment has a vascular wall strengthening effect. In one embodiment, a beauty product for strengthening blood vessel walls containing soy protein and / or ergothioneine is provided. In this embodiment, the contents of soy protein, ergothioneine, etc., and other For the type and content of the ingredients, the formulation and use of the cosmetic composition, etc., please refer to [1. Vascular wall Reinforcement Agent].

[0019] <Method of manufacturing a cosmetic composition for strengthening blood vessel walls> The method for producing the cosmetic composition for strengthening blood vessel walls according to the present embodiment is not particularly limited. Wall strengthening agent (preparation characterized by containing soy protein and / or ergothioneine) The above-mentioned vascular wall strengthening agent (soy protein and / or ergothioneamide) is blended. Nein), and other optional ingredients (base or carrier, additives, etc.) are appropriately selected and mixed as necessary. The mixture can be prepared by a conventional method.

[0020] The cosmetic composition for strengthening blood vessel walls of the present invention increases pericytes by using the blood vessel wall strengthening agent of the present invention. It promotes blood growth, stabilizes the structure of blood vessels, and strengthens blood vessels, improving blood flow and reducing hemoglobin levels. Prevents and / or improves the reduction of globin levels, dilation and thickening of blood vessels, and prevents and / or improves dark circles under the eyes. It can have cosmetic effects such as preventing and / or improving dull skin tone. Therefore, the cosmetic composition for strengthening blood vessel walls of the present invention can improve and enhance skin tone and skin beauty. In this way, the cosmetic composition for strengthening blood vessel walls of the present invention is effective for, for example, a cosmetic liquid. , lotion, milky lotion, cream, gel cream, beauty mask (face mask), makeup base It is suitable for use as a composition for external use such as foundation, sunscreen, cleansing agent, detergent, etc. More preferably, it can be used as a beauty essence, a lotion, a milky lotion, a cream, or a gel cream. In addition, the exosome secretion promoting agent of the present invention can be used as a skin care product. The cosmetic composition for use may be a food composition. The food composition may be a health food, a nutritional supplement, or the like. It can be suitably used as a food supplement (including balanced nutritional foods, supplements, etc.). In addition, it is popular as a health food (specified health food (including disease risk reduction labeling and standard standard type)). It is appropriate.

[0021] The administration or application method of the vascular wall strengthening agent or vascular wall strengthening cosmetic composition of the present invention is as follows: Examples of administration include transdermal administration and oral administration, but the most suitable administration method is selected according to the type of disease or symptom and the purpose of use. A suitable method can be selected.

[0022] [3. Beauty method for strengthening blood vessel walls] The cosmetic method according to the present embodiment has a vascular wall strengthening effect. In the form of a cosmetic composition containing soy protein and / or ergothioneine, the cosmetic composition is applied to the skin. A cosmetic method for improving and / or preventing conditions caused by the loss of pericytes (provided that In one embodiment of the present invention, the soy protein is A cosmetic composition containing pac and / or ergothioneine was orally administered to the subjects, and the pericyte digestion was evaluated. Cosmetic methods for improving and / or preventing conditions caused by loss of function (however, methods for treating human diseases are not included) (excluding the law) is provided.

[0023] In this embodiment, the contents of soy protein, ergothioneine, and other components are For the type and content of ingredients, formulation form and use of beauty products, etc., please refer to [1. Vascular wall strengthening agent]. ] as explained above. EXAMPLES

[0024] The present invention will be specifically described below based on test examples, but the present invention is not limited to these. In the following examples, the blend amounts are expressed as mass % unless otherwise specified.

[0025] [Test Example 1: Evaluation of pericyte proliferation ability] A frozen vial of pericytes (HBVP, ScienCell) was put to sleep and incubated for 5,000 h. cells / cm 2 So that's 75cm 2 Seed the flasks and incubate at 37°C, 5% CO 2 conditions The pericytes were then cultured under low temperature for 3 days. After detaching the pericytes from the flask by trypsinization, Pericytes were plated in a 96-well plate at 4000 cells / 100 uL / well. The cells were seeded onto plates and cultured for 24 hours. Pericyte Medium (PM) containing 0.2% FBS containing the components shown in Table 1 (manufactured by ScienCell) was added to a 96-well plate after removing the medium by aspiration. The final concentrations of each component are shown in Table 1. The soy protein is a thermolysin hydrolysate of soy protein. The test solution containing the Mogitake extract contained 0.000015% by mass of ergothioneine. The control was cultured for two days in medium without any ingredients. The medium was removed, and 1000-fold diluted Hoechst33342 (Dojindo Laboratories) was added. ) was added and incubated for 15 minutes in the dark to stain the nuclei of the pericytes. eXpress and the absorbance at 450 nm was measured using a microplate reader. Measure and obtain cell counts. The number of cells in each test solution was calculated relative to 100 cells in the control solution, and the calculated value was used as the pericyte concentration of each test solution. The proliferation ability was measured and is shown in Table 1.

[0026] [Table 1]

[0027] As shown in Table 1, test solution 1 contains soy protein hydrolysate, test solution 2 contains Tamogitake mushroom extract, Test solution 2, which contains soy protein hydrolysate, had a higher proliferation ability of pericytes than the control. Test solution 3 containing the Mogitake extract showed an even greater improvement in the proliferation ability of pericytes.

[0028] [Test Example 2: Skin Evaluation] Formulation Example 1 was prepared using known techniques. Subjects applied the product under their eyes twice a day (morning and night). The application of Example 1 was continued for 8 weeks. The subjects were photographed using a facial image analyzer ( The photographs were taken with a digital camera (Visia, Canfield, Inc.) or a face image analysis device. The results of the photograph taken with a digital camera are shown in Figure 1 and Figure 2, respectively.

[0029] Prescription Example 1 Tamogitake mushroom extract * 0.00025 (mass%) Hydrolyzed Soy Protein 0.1 1,3-Butylene glycol 10.0 Caprylyl Methicone 5.0 Cyclopentasiloxane 7.0 Dimethicone 10.0 Squalane 2.0 Diethoxyethyl succinate 2.0 Tocopherol 0.2 Sorbitan Monostearate 2.0 Cetyl PEG / PPG-10 / 1 Dimethicone 2.0 Boron Nitride 3.0 Silicone-treated titanium oxide coated mica 2.0 Dimethyl distearyl ammonium hectorite 0.8 Tribehenin 0.1 Distilled water remaining Total 100.0% *: indicates the pure amount of extract.

[0030] As shown in Figures 1 and 2, the eyelids were more pigmented after 8 weeks of application (right) compared to before application (left). The dark circles under the eyes have become lighter. In addition, after 8 weeks of application, the skin around the cheekbones has become less dull compared to before application. As a result, the skin overall became brighter, more translucent, and more even-toned.

[0031] [Test Example 3: Blood flow evaluation] Formulation Example 1 was prepared using known techniques. Subjects applied the product under their eyes twice a day (morning and night). Application of Example 1 was continued for 8 weeks. The application site was examined by laser scanning before and after 8 weeks of application. A two-dimensional blood flow imaging device (Omega Zone OZ-1, Omega Wave Co., Ltd.) was used to measure blood flow. The blood flow volume was monitored. The distribution of blood flow was displayed as a grayscale image in Figure 3. The more blood flow, the whiter (brighter) it appears, and the less blood flow, the blacker (darker) it appears. The dotted lines in Figure 3(a) and (b) show the upper and lower eyelashes when the eyes are closed. Figures 3(a) and (c), and Figures 3(b) and (d) are the same image.

[0032] As shown in Figure 3, the results are clear 8 weeks after application (Figure (d)) compared to before application (Figure (c)). In addition, the entire applied area was bright, and blood flow was significantly improved. It can be seen that blood flow has improved. Therefore, in the area where Formulation Example 1 was applied, the blood flow was After eight weeks of application, blood flow improved, and the blood flow improving ability was enhanced. The subjects commented that dark circles under their eyes were less noticeable after 8 weeks of application than before they started. The patient evaluated the product and said that after eight weeks of continued application, she felt that her dark circles under the eyes were gradually fading.

[0033] Using known techniques, a vascular strengthening agent was prepared for Formulation Example 2. Formulation Example 2 was used without any problems. It was possible to use it. Prescription Example 2 Tamogitake mushroom extract * 0.00025 (mass%) Hydrolyzed Soy Protein 0.1 1,3-Butylene glycol 7.0 Glycerin 3.0 Polyglyceryl Monostearate 2.0 Glyceryl Monostearate 1.5 Squalane 5.0 Glyceryl triethylhexanoate 3.0 Stearyl alcohol 0.3 Behenyl alcohol 0.1 Carboxyvinyl polymer 0.2 Triethanolamine (appropriate amount) Distilled water remaining Total 100.0% *: indicates the pure amount of extract.

Claims

1. A vascular wall strengthening agent containing soybean protein and / or Pleurotus cornucopiae extract as an active ingredient (excluding the following (1) to (9)). (1) A composition comprising a denatured soy protein in which the trypsin inhibitory activity of soybean trypsin inhibitor (STI) protein has been inactivated and the activity of Bowman-Birk inhibitor (BBI) has been retained; (2) Water, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Ethylhexyl Palmitate, Jojoba Seed Oil, Glycerin, Niacinamide, Sunflower Seed Oil, Nylon-12, Phenoxyethanol, Cetanol, Fraxinus Excisediana Bark Extract, Avena Sativa (Oat) Extract, Ethylhexylglycerin, Carbomer, Panthenol, Polyacrylamide, Caffeine, Titanium Dioxide, Sodium Hydroxide, Retinyl Palmitate, C13-14 Isoparaffin, Sodium EDTA, Caprylic / Capric Triglyceride, Hydrolyzed Soy Protein, Tocopherol, Glycolic Acid, Silanetriol, Cetearyl Alcohol, Laureth-7, Potassium Behenoyl Eye care products containing Hydroxyproline, Potassium Citrate, Scutellaria Alpina Flower / Leaf / Stem Extract, Behenic Acid, Snowdrop Bulb Extract, Angelica Root Extract, Citric Acid, Potassium Sorbate, Sodium Benzoate, Sorbic Acid, Ethyl Bisiminomethyl Guaiacol Manganese Chloride, Rosa Centifolia Flower Extract; (3) An eye mask containing water, collagen, damask rose flower water, hydrolyzed soy protein, lactoglobulin, sodium hyaluronate, HEC, panthenol, allantoin, Aloe Barbadensis Extract, lactic acid, glycerin, methylparaben, sodium citrate, and citric acid; (4) Rosemary leaf extract 0.01-5.0%, Alpinia speciosa leaf extract 0.01-5.0%, Ultrasomes 0.05-3.0%, Avena sativa kernel extract 0.01-5.0%, Evening primrose seed extract 0.01-5.0%, L-ergothioneine 0.01-5.0%, hydrolyzed soy protein 0.01-5.0%, yeast protein, lentinus enodes extract 0.01-5.0%, Nymphaea alba flower extract 0.01-5.0%, Perilla a cosmetic composition comprising 0.01-1.0% of Frutescens leaf extract, 0.1-3.0% of vitamins, 0.5-2.0% of preservatives, 10.0-25.0% of moisturizers, 0.2-1.5% of anti-irritants, 0.2-1.0% of pH adjusters, 0.05-1.5% of thickeners, 1.0-5.0% of emollients, and water; (5) A topical cream containing up to 100% water, 0.1% by weight disodium EDTA, 0.5% by weight dexpanthenol, 2.0% by weight niacinamide, 5.0% by weight glycerin, 2.0% by weight hydrolyzed soy protein, 3.0% by weight isohexadecane, 1.0% by weight isopropyl isostearate, 0.4% by weight stearic acid, 0.5% by weight tocopherol acetate, 0.2% by weight cetearyl glucoside, 1.0% by weight cetyl alcohol, 0.5% by weight polymethylsilsesquioxane, a pH adjusting amount of sodium hydroxide, and 1.5% by weight Sepigel 305; (6) Water up to 100%, Carbobol 1382 0.25% by weight, butylene glycol 1.0% by weight, glycerin 2.5% by weight, sodium hyaluronate 1.0% by weight, methylparaben 0.1% by weight, titanium dioxide 0.75% by weight, hydrolyzed soy protein 1.5% by weight, isocetyl stearate 2.0% by weight, PEG-100 stearate 2.0% by weight, glyceryl stearate 2.0% by weight, petrolatum 1.0% by weight, cetearyl alcohol 1.0% by weight, glyceryl stearate ... a topical cream containing 1.0% by weight of glyceryl stearate, 1.0% by weight of isocetyl alcohol, 0.5% by weight of cetyl ricinoleate, 0.5% by weight of polyglyceryl 3 beeswax, 0.5% by weight of cholesterol, 0.2% by weight of cetearyl glucoside, 0.2% by weight of propylparaben, 0.5% by weight of dimethicone copolyol, 0.75% by weight of dimethicone, 0.5% by weight of polytetrafluoroethylene or 0.5% by weight of polymethylsilsesquioxane, and 1.0% by weight of Sepigel 501; (7) a topical cream comprising up to 100% water, 2.5% by weight glycerin, 1.0% by weight butylene glycol, 0.1% by weight methylparaben, 2.5% by weight hydrolyzed soy protein, 2.5% by weight hydrogenated polyisobutene, 2.0% by weight mineral oil, 1.0% by weight glyceryl stearate, 1.0% by weight cetyl alcohol, 1.5% by weight PEG-40 stearate, 1.0% by weight sorbitan tristearate, 1.5% by weight dimethicone, 1.0% by weight cyclopentasiloxane, 1.0% by weight nylon-12, 0.5% by weight whey protein, and 1.0% by weight Sepigel 305; (8) Water, cyclopentasiloxane, glycerin, dimethicone, caprylic / capric / myristic / stearic acid triglyceride, polysilicone-11, hydrogenated polyisobutene (hydrolyzed), cetyl PEG / PPG-10 / 1 dimethicone, isononyl isononanoate, nylon-12, magnesium sulfate, sucrose trehalose, dimethicone crosspolymer, algae extract, butylene glycol, phenoxyethanol, propylene glycol dicaprate, N-acetylglucosamine, algae extract, sunflower seed Cake, Cyclohexasiloxane, Tocopheryl Acetate, Caprylyl Glycol, PEG / PPG-18 / 18 Dimethicone, Sorbitol, Silica, Cholesterol, Lauryl Pyrrolidone Carboxylate, Caffeine, Caprylic / Capric Triglyceride, Agarwood Extract, Whey Protein, BHT, Sodium Hyaluronate, Polygonum Cuspidarum Root Extract, Sodium Disodium EDTA, Hexanediol, Cyclodextrin, Barley Extract, Swertia Chiretta Extract, Eyebright, Roman Chamomile Extract, Sodium Benzoate, Dried Aluminum Hydroxide Gel, Bioflavonoids, Laminaria Digitata Extract, Ascophyllum Nodosum Extract, Cladophora Okinawana Extract, Pearl Powder, Cordyceps Sinensis Extract, Decarboxycarnosine HCl, Polymethylsilsesquioxane, Fuscoporia Obliqua Sclerotium Eye Cream containing: Extract, Cucumber Fruit Extract, Saccharomyces Lysate, Citric Acid, Triethoxycaprylylsilane, Narcissus Tazetta Root Extract, Cellulose, Artemia Extract, Asparagopsis Armata Extract, Linoleic Acid, Propylene Glycol Diethylhexanoate, Soy Protein, Yeast Extract, Lecithin, Ethyl Bis-Iminomethyl Guaiacol Manganese Chloride, Acetyl Hexapeptide-8, Pyrus Malus (Apple) Extract, Ergothioneine, Scutellaria Baicalensis Extract, Gelidium Carchilagineum Extract, Gold, Hydrolyzed Wheat Protein, Mica, Titanium Dioxide, Iron Oxide (CI 77491); (9) Composition containing water, BG, olefin oligomer, diglycerin, tocopherol nicotinate, glucosyl hesperidin, comfrey extract, emmalok fruit extract, arginine, Oenothera Biennis (Evening Primerose Oil), hydrolyzed soy protein, European grape seed extract, trimethylglycine, dextrin, maltodextrin, dimethicone, glyceryl stearate, PEG-20 sorbitan isostearate, (acrylates / alkyl acrylate (C10-30)) crosspolymer, sodium edetate, TEA, methylparaben, propylparaben, and fragrance).

2. The vascular wall strengthening agent according to claim 1, wherein the amount of the soy protein is 0.00001 to 2% by mass, and / or the amount of the maitake mushroom extract is 0.00001 to 0.01% by mass.

3. 2. The vascular wall strengthening agent according to claim 1, wherein the soy protein is a soy protein hydrolysate.

4. A pericyte proliferation promoter containing soybean protein and / or Pleurotus cornucopiae extract as an active ingredient (excluding the following (1) to (7)). (1) Water, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Ethylhexyl Palmitate, Jojoba Seed Oil, Glycerin, Niacinamide, Sunflower Seed Oil, Nylon-12, Phenoxyethanol, Cetanol, Fraxinus Exciseda Bark Extract, Avena Sativa (Oat) Extract, Ethylhexylglycerin, Carbomer, Panthenol, Polyacrylamide, Caffeine, Titanium Dioxide, Sodium Hydroxide, Retinyl Palmitate, C13-14 Isoparaffin, Sodium EDTA, Caprylic / Capric Triglyceride, Hydrolyzed Soy Protein, Tocopherol, Glycolic Acid, Silanetriol, Cetearyl Alcohol, Laureth-7, Potassium Behenoyl Eye care products containing Hydroxyproline, Potassium Citrate, Scutellaria Alpina Flower / Leaf / Stem Extract, Behenic Acid, Snowdrop Bulb Extract, Angelica Root Extract, Citric Acid, Potassium Sorbate, Sodium Benzoate, Sorbic Acid, Ethyl Bisiminomethyl Guaiacol Manganese Chloride, Rosa Centifolia Flower Extract; (2) An eye mask containing water, collagen, damask rose flower water, hydrolyzed soy protein, lactoglobulin, sodium hyaluronate, HEC, panthenol, allantoin, Aloe Barbadensis Extract, lactic acid, glycerin, methylparaben, sodium citrate, and citric acid; (3) Rosemary leaf extract 0.01-5.0%, Alpinia speciosa leaf extract 0.01-5.0%, Ultrasomes 0.05-3.0%, Avena sativa kernel extract 0.01-5.0%, Evening primrose seed extract 0.01-5.0%, L-ergothioneine 0.01-5.0%, hydrolyzed soy protein 0.01-5.0%, yeast protein, lentinus enodes extract 0.01-5.0%, Nymphaea alba flower extract 0.01-5.0%, Perilla a cosmetic composition comprising 0.01-1.0% of Frutescens leaf extract, 0.1-3.0% of vitamins, 0.5-2.0% of preservatives, 10.0-25.0% of moisturizers, 0.2-1.5% of anti-irritants, 0.2-1.0% of pH adjusters, 0.05-1.5% of thickeners, 1.0-5.0% of emollients, and water; (4) A topical cream containing up to 100% water, 0.1% by weight disodium EDTA, 0.5% by weight dexpanthenol, 2.0% by weight niacinamide, 5.0% by weight glycerin, 2.0% by weight hydrolyzed soy protein, 3.0% by weight isohexadecane, 1.0% by weight isopropyl isostearate, 0.4% by weight stearic acid, 0.5% by weight tocopherol acetate, 0.2% by weight cetearyl glucoside, 1.0% by weight cetyl alcohol, 0.5% by weight polymethylsilsesquioxane, a pH adjusting amount of sodium hydroxide, and 1.5% by weight Sepigel 305; (5) Water up to 100%, Carbobol 1382 0.25% by weight, butylene glycol 1.0% by weight, glycerin 2.5% by weight, sodium hyaluronate 1.0% by weight, methylparaben 0.1% by weight, titanium dioxide 0.75% by weight, hydrolyzed soy protein 1.5% by weight, isocetyl stearate 2.0% by weight, PEG-100 stearate 2.0% by weight, glyceryl stearate 2.0% by weight, petrolatum 1.0% by weight, cetearyl alcohol 1.0% by weight, glyceryl stearate ... a topical cream containing 1.0% by weight of glyceryl stearate, 1.0% by weight of isocetyl alcohol, 0.5% by weight of cetyl ricinoleate, 0.5% by weight of polyglyceryl 3 beeswax, 0.5% by weight of cholesterol, 0.2% by weight of cetearyl glucoside, 0.2% by weight of propylparaben, 0.5% by weight of dimethicone copolyol, 0.75% by weight of dimethicone, 0.5% by weight of polytetrafluoroethylene or 0.5% by weight of polymethylsilsesquioxane, and 1.0% by weight of Sepigel 501; (6) a topical cream comprising up to 100% water, 2.5% by weight glycerin, 1.0% by weight butylene glycol, 0.1% by weight methylparaben, 2.5% by weight hydrolyzed soy protein, 2.5% by weight hydrogenated polyisobutene, 2.0% by weight mineral oil, 1.0% by weight glyceryl stearate, 1.0% by weight cetyl alcohol, 1.5% by weight PEG-40 stearate, 1.0% by weight sorbitan tristearate, 1.5% by weight dimethicone, 1.0% by weight cyclopentasiloxane, 1.0% by weight nylon-12, 0.5% by weight whey protein, and 1.0% by weight Sepigel 305; (7) Water, cyclopentasiloxane, glycerin, dimethicone, caprylic / capric / myristic / stearic acid triglyceride, polysilicone-11, hydrogenated polyisobutene (hydrolyzed), cetyl PEG / PPG-10 / 1 dimethicone, isononyl isononanoate, nylon-12, magnesium sulfate, sucrose, trehalose, dimethicone crosspolymer, algae extract, butylene glycol, phenoxyethanol, propylene glycol dicaprate, N-acetylglucosamine, algae extract, sunflower seed Cake, Cyclohexasiloxane, Tocopheryl Acetate, Caprylyl Glycol, PEG / PPG-18 / 18 Dimethicone, Sorbitol, Silica, Cholesterol, Lauryl Pyrrolidone Carboxylate, Caffeine, Caprylic / Capric Triglyceride, Agarwood Extract, Whey Protein, BHT, Sodium Hyaluronate, Polygonum Cuspidarum Root Extract, Sodium Disodium EDTA, Hexanediol, Cyclodextrin, Barley Extract, Swertia Chiretta Extract, Eyebright, Roman Chamomile Extract, Sodium Benzoate, Dried Aluminum Hydroxide Gel, Bioflavonoids, Laminaria Digitata Extract, Ascophyllum Nodosum Extract, Cladophora Okinawana Extract, Pearl Powder, Cordyceps Sinensis Extract, Decarboxycarnosine HCl, Polymethylsilsesquioxane, Fuscoporia Obliqua Sclerotium Eye Cream containing: Cucumber Fruit Extract, Saccharomyces Lysate, Citric Acid, Triethoxycaprylylsilane, Narcissus Tazetta Root Extract, Cellulose, Artemia Extract, Asparagopsis Armata Extract, Linoleic Acid, Propylene Glycol Diethylhexanoate, Soy Protein, Yeast Extract, Lecithin, Ethyl Bis-Iminomethyl Guaiacol Manganese Chloride, Acetyl Hexapeptide-8, Pyrus Malus (Apple) Extract, Ergothioneine, Scutellaria Baicalensis Extract, Gelidium Carchilagineum Extract, Gold, Hydrolyzed Wheat Protein, Mica, Titanium Dioxide, Iron Oxides (CI 77491).

5. The pericyte proliferation promoter according to claim 4, wherein the amount of the soybean protein is 0.00001 to 2% by mass and / or the amount of the maitake mushroom extract is 0.00001 to 0.01% by mass.

6. The pericyte proliferation promoter according to claim 4 , wherein the soybean protein is a soybean protein hydrolysate.

7. A skin tone improver containing soy protein and / or Pleurotus cornucopiae extract as active ingredients, wherein the improvement in skin tone is to brighten the entire skin and increase transparency, or to improve dullness of the skin or dark circles under the eyes (excluding the following (1) to (8)). (1) Water, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Ethylhexyl Palmitate, Jojoba Seed Oil, Glycerin, Niacinamide, Sunflower Seed Oil, Nylon-12, Phenoxyethanol, Cetanol, Fraxinus Exciseda Bark Extract, Avena Sativa (Oat) Extract, Ethylhexylglycerin, Carbomer, Panthenol, Polyacrylamide, Caffeine, Titanium Dioxide, Sodium Hydroxide, Retinyl Palmitate, C13-14 Isoparaffin, Sodium EDTA, Caprylic / Capric Triglyceride, Hydrolyzed Soy Protein, Tocopherol, Glycolic Acid, Silanetriol, Cetearyl Alcohol, Laureth-7, Potassium Behenoyl Eye care products containing Hydroxyproline, Potassium Citrate, Scutellaria Alpina Flower / Leaf / Stem Extract, Behenic Acid, Snowdrop Bulb Extract, Angelica Root Extract, Citric Acid, Potassium Sorbate, Sodium Benzoate, Sorbic Acid, Ethyl Bisiminomethyl Guaiacol Manganese Chloride, Rosa Centifolia Flower Extract; (2) An eye mask containing water, collagen, damask rose flower water, hydrolyzed soy protein, lactoglobulin, sodium hyaluronate, HEC, panthenol, allantoin, Aloe Barbadensis Extract, lactic acid, glycerin, methylparaben, sodium citrate, and citric acid; (3) Rosemary leaf extract 0.01-5.0%, Alpinia speciosa leaf extract 0.01-5.0%, Ultrasomes 0.05-3.0%, Avena sativa kernel extract 0.01-5.0%, Evening primrose seed extract 0.01-5.0%, L-ergothioneine 0.01-5.0%, hydrolyzed soy protein 0.01-5.0%, yeast protein, lentinus enodes extract 0.01-5.0%, Nymphaea alba flower extract 0.01-5.0%, Perilla a cosmetic composition comprising 0.01-1.0% of Frutescens leaf extract, 0.1-3.0% of vitamins, 0.5-2.0% of preservatives, 10.0-25.0% of moisturizers, 0.2-1.5% of anti-irritants, 0.2-1.0% of pH adjusters, 0.05-1.5% of thickeners, 1.0-5.0% of emollients, and water; (4) A topical cream containing up to 100% water, 0.1% by weight disodium EDTA, 0.5% by weight dexpanthenol, 2.0% by weight niacinamide, 5.0% by weight glycerin, 2.0% by weight hydrolyzed soy protein, 3.0% by weight isohexadecane, 1.0% by weight isopropyl isostearate, 0.4% by weight stearic acid, 0.5% by weight tocopherol acetate, 0.2% by weight cetearyl glucoside, 1.0% by weight cetyl alcohol, 0.5% by weight polymethylsilsesquioxane, a pH adjusting amount of sodium hydroxide, and 1.5% by weight Sepigel 305; (5) Water up to 100%, Carbobol 1382 0.25% by weight, butylene glycol 1.0% by weight, glycerin 2.5% by weight, sodium hyaluronate 1.0% by weight, methylparaben 0.1% by weight, titanium dioxide 0.75% by weight, hydrolyzed soy protein 1.5% by weight, isocetyl stearate 2.0% by weight, PEG-100 stearate 2.0% by weight, glyceryl stearate 2.0% by weight, petrolatum 1.0% by weight, cetearyl alcohol 1.0% by weight, glyceryl stearate ... a topical cream containing 1.0% by weight of glyceryl stearate, 1.0% by weight of isocetyl alcohol, 0.5% by weight of cetyl ricinoleate, 0.5% by weight of polyglyceryl 3 beeswax, 0.5% by weight of cholesterol, 0.2% by weight of cetearyl glucoside, 0.2% by weight of propylparaben, 0.5% by weight of dimethicone copolyol, 0.75% by weight of dimethicone, 0.5% by weight of polytetrafluoroethylene or 0.5% by weight of polymethylsilsesquioxane, and 1.0% by weight of Sepigel 501; (6) a topical cream comprising up to 100% water, 2.5% by weight glycerin, 1.0% by weight butylene glycol, 0.1% by weight methylparaben, 2.5% by weight hydrolyzed soy protein, 2.5% by weight hydrogenated polyisobutene, 2.0% by weight mineral oil, 1.0% by weight glyceryl stearate, 1.0% by weight cetyl alcohol, 1.5% by weight PEG-40 stearate, 1.0% by weight sorbitan tristearate, 1.5% by weight dimethicone, 1.0% by weight cyclopentasiloxane, 1.0% by weight nylon-12, 0.5% by weight whey protein, and 1.0% by weight Sepigel 305; (7) Water, cyclopentasiloxane, glycerin, dimethicone, caprylic / capric / myristic / stearic acid triglyceride, polysilicone-11, hydrogenated polyisobutene (hydrolyzed), cetyl PEG / PPG-10 / 1 dimethicone, isononyl isononanoate, nylon-12, magnesium sulfate, sucrose, trehalose, dimethicone crosspolymer, algae extract, butylene glycol, phenoxyethanol, propylene glycol dicaprate, N-acetylglucosamine, algae extract, sunflower seed Cake, Cyclohexasiloxane, Tocopheryl Acetate, Caprylyl Glycol, PEG / PPG-18 / 18 Dimethicone, Sorbitol, Silica, Cholesterol, Lauryl Pyrrolidone Carboxylate, Caffeine, Caprylic / Capric Triglyceride, Agarwood Extract, Whey Protein, BHT, Sodium Hyaluronate, Polygonum Cuspidarum Root Extract, Sodium Disodium EDTA, Hexanediol, Cyclodextrin, Barley Extract, Swertia Chiretta Extract, Eyebright, Roman Chamomile Extract, Sodium Benzoate, Dried Aluminum Hydroxide Gel, Bioflavonoids, Laminaria Digitata Extract, Ascophyllum Nodosum Extract, Cladophora Okinawana Extract, Pearl Powder, Cordyceps Sinensis Extract, Decarboxycarnosine HCl, Polymethylsilsesquioxane, Fuscoporia Obliqua Sclerotium Eye Cream containing: Extract, Cucumber Fruit Extract, Saccharomyces Lysate, Citric Acid, Triethoxycaprylylsilane, Narcissus Tazetta Root Extract, Cellulose, Artemia Extract, Asparagopsis Armata Extract, Linoleic Acid, Propylene Glycol Diethylhexanoate, Soy Protein, Yeast Extract, Lecithin, Ethyl Bis-Iminomethyl Guaiacol Manganese Chloride, Acetyl Hexapeptide-8, Pyrus Malus (Apple) Extract, Ergothioneine, Scutellaria Baicalensis Extract, Gelidium Carchilagineum Extract, Gold, Hydrolyzed Wheat Protein, Mica, Titanium Dioxide, Iron Oxide (CI 77491); (8) Composition containing water, BG, olefin oligomer, diglycerin, tocopherol nicotinate, glucosyl hesperidin, comfrey extract, emmalok fruit extract, arginine, Oenothera Biennis (Evening Primerose Oil), hydrolyzed soy protein, European grape seed extract, trimethylglycine, dextrin, maltodextrin, dimethicone, glyceryl stearate, PEG-20 sorbitan isostearate, (acrylates / alkyl acrylate (C10-30)) crosspolymer, sodium edetate, TEA, methylparaben, propylparaben, and fragrance).

8. The skin tone improving agent of claim 7, wherein the amount of the soy protein is 0.00001 to 2% by mass and / or the amount of the maitake mushroom extract is 0.00001 to 0.01% by mass.

9. The skin tone improving agent according to claim 7 , wherein the soy protein is a soy protein hydrolysate.

10. A vascular wall strengthening agent containing soybean protein and / or ergothioneine as an active ingredient, the ergothioneine being contained as a coral reed extract (excluding the following (1) to (10)). (1) A composition comprising a denatured soy protein in which the trypsin inhibitory activity of soybean trypsin inhibitor (STI) protein has been inactivated and the activity of Bowman-Birk inhibitor (BBI) has been retained; (2) Water, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Ethylhexyl Palmitate, Jojoba Seed Oil, Glycerin, Niacinamide, Sunflower Seed Oil, Nylon-12, Phenoxyethanol, Cetanol, Fraxinus Excisediana Bark Extract, Avena Sativa (Oat) Extract, Ethylhexylglycerin, Carbomer, Panthenol, Polyacrylamide, Caffeine, Titanium Dioxide, Sodium Hydroxide, Retinyl Palmitate, C13-14 Isoparaffin, Sodium EDTA, Caprylic / Capric Triglyceride, Hydrolyzed Soy Protein, Tocopherol, Glycolic Acid, Silanetriol, Cetearyl Alcohol, Laureth-7, Potassium Behenoyl Eye care products containing Hydroxyproline, Potassium Citrate, Scutellaria Alpina Flower / Leaf / Stem Extract, Behenic Acid, Snowdrop Bulb Extract, Angelica Root Extract, Citric Acid, Potassium Sorbate, Sodium Benzoate, Sorbic Acid, Ethyl Bisiminomethyl Guaiacol Manganese Chloride, Rosa Centifolia Flower Extract; (3) An eye mask containing water, collagen, damask rose flower water, hydrolyzed soy protein, lactoglobulin, sodium hyaluronate, HEC, panthenol, allantoin, Aloe Barbadensis Extract, lactic acid, glycerin, methylparaben, sodium citrate, and citric acid; (4) Rosemary leaf extract 0.01-5.0%, Alpinia speciosa leaf extract 0.01-5.0%, Ultrasomes 0.05-3.0%, Avena sativa kernel extract 0.01-5.0%, Evening primrose seed extract 0.01-5.0%, L-ergothioneine 0.01-5.0%, hydrolyzed soy protein 0.01-5.0%, yeast protein, lentinus enodes extract 0.01-5.0%, Nymphaea alba flower extract 0.01-5.0%, Perilla a cosmetic composition comprising 0.01-1.0% of Frutescens leaf extract, 0.1-3.0% of vitamins, 0.5-2.0% of preservatives, 10.0-25.0% of moisturizers, 0.2-1.5% of anti-irritants, 0.2-1.0% of pH adjusters, 0.05-1.5% of thickeners, 1.0-5.0% of emollients, and water; (5) A topical cream containing up to 100% water, 0.1% by weight disodium EDTA, 0.5% by weight dexpanthenol, 2.0% by weight niacinamide, 5.0% by weight glycerin, 2.0% by weight hydrolyzed soy protein, 3.0% by weight isohexadecane, 1.0% by weight isopropyl isostearate, 0.4% by weight stearic acid, 0.5% by weight tocopherol acetate, 0.2% by weight cetearyl glucoside, 1.0% by weight cetyl alcohol, 0.5% by weight polymethylsilsesquioxane, a pH adjusting amount of sodium hydroxide, and 1.5% by weight Sepigel 305; (6) Water up to 100%, Carbobol 1382 0.25% by weight, butylene glycol 1.0% by weight, glycerin 2.5% by weight, sodium hyaluronate 1.0% by weight, methylparaben 0.1% by weight, titanium dioxide 0.75% by weight, hydrolyzed soy protein 1.5% by weight, isocetyl stearate 2.0% by weight, PEG-100 stearate 2.0% by weight, glyceryl stearate 2.0% by weight, petrolatum 1.0% by weight, cetearyl alcohol 1.0% by weight, glyceryl stearate ... a topical cream containing 1.0% by weight of glyceryl stearate, 1.0% by weight of isocetyl alcohol, 0.5% by weight of cetyl ricinoleate, 0.5% by weight of polyglyceryl 3 beeswax, 0.5% by weight of cholesterol, 0.2% by weight of cetearyl glucoside, 0.2% by weight of propylparaben, 0.5% by weight of dimethicone copolyol, 0.75% by weight of dimethicone, 0.5% by weight of polytetrafluoroethylene or 0.5% by weight of polymethylsilsesquioxane, and 1.0% by weight of Sepigel 501; (7) a topical cream comprising up to 100% water, 2.5% by weight glycerin, 1.0% by weight butylene glycol, 0.1% by weight methylparaben, 2.5% by weight hydrolyzed soy protein, 2.5% by weight hydrogenated polyisobutene, 2.0% by weight mineral oil, 1.0% by weight glyceryl stearate, 1.0% by weight cetyl alcohol, 1.5% by weight PEG-40 stearate, 1.0% by weight sorbitan tristearate, 1.5% by weight dimethicone, 1.0% by weight cyclopentasiloxane, 1.0% by weight nylon-12, 0.5% by weight whey protein, and 1.0% by weight Sepigel 305; (8) Water, cyclopentasiloxane, glycerin, dimethicone, caprylic / capric / myristic / stearic acid triglyceride, polysilicone-11, hydrogenated polyisobutene (hydrolyzed), cetyl PEG / PPG-10 / 1 dimethicone, isononyl isononanoate, nylon-12, magnesium sulfate, sucrose, trehalose, dimethicone crosspolymer, algae extract, butylene glycol, phenoxyethanol, propylene glycol dicaprate, N-acetylglucosamine, algae extract, sunflower seed Cake, Cyclohexasiloxane, Tocopheryl Acetate, Caprylyl Glycol, PEG / PPG-18 / 18 Dimethicone, Sorbitol, Silica, Cholesterol, Lauryl Pyrrolidone Carboxylate, Caffeine, Caprylic / Capric Triglyceride, Agarwood Extract, Whey Protein, BHT, Sodium Hyaluronate, Polygonum Cuspidarum Root Extract, Sodium Disodium EDTA, Hexanediol, Cyclodextrin, Barley Extract, Swertia Chiretta Extract, Eyebright, Roman Chamomile Extract, Sodium Benzoate, Dried Aluminum Hydroxide Gel, Bioflavonoids, Laminaria Digitata Extract, Ascophyllum Nodosum Extract, Cladophora Okinawana Extract, Pearl Powder, Cordyceps Sinensis Extract, Decarboxycarnosine HCl, Polymethylsilsesquioxane, Fuscoporia Obliqua Sclerotium Eye Cream containing: Extract, Cucumber Fruit Extract, Saccharomyces Lysate, Citric Acid, Triethoxycaprylylsilane, Narcissus Tazetta Root Extract, Cellulose, Artemia Extract, Asparagopsis Armata Extract, Linoleic Acid, Propylene Glycol Diethylhexanoate, Soy Protein, Yeast Extract, Lecithin, Ethyl Bis-Iminomethyl Guaiacol Manganese Chloride, Acetyl Hexapeptide-8, Pyrus Malus (Apple) Extract, Ergothioneine, Scutellaria Baicalensis Extract, Gelidium Carchilagineum Extract, Gold, Hydrolyzed Wheat Protein, Mica, Titanium Dioxide, Iron Oxide (CI 77491); (9) A composition comprising water, BG, olefin oligomer, diglycerin, tocopherol nicotinate, glucosyl hesperidin, comfrey extract, emmalok fruit extract, arginine, Oenothera Biennis (Evening Primerose Oil), hydrolyzed soy protein, Vitis Vinifera seed extract, trimethylglycine, dextrin, maltodextrin, dimethicone, glyceryl stearate, PEG-20 sorbitan isostearate, (acrylates / C10-30 alkyl acrylate crosspolymer), sodium edetate, TEA, methylparaben, propylparaben, and fragrance; (10) Cream containing water, butylene glycol, dimethicone, phenyl trimethicone, cyclopentasiloxane, glycerin, glyceryl amidoethyl methacrylate / stearyl methacrylate copolymer, artemia extract, ergothioneine, oligopeptide-6, chrysanthellum indicum extract, dipotassium glycyrrhizinate, hedera helix extract, cecropia obtusifolia bark extract, hexapeptide-3, magnesium ascorbyl phosphate, hydrolyzed sesame seed, tocopheryl acetate, C12-14 pareth-3, PPG-12 / SMDI copolymer, 1,2-hexanediol, PEG-60 hydrogenated castor oil (hydrolyzed), oleth-7, carbomer, xanthan gum, magnesium aluminosilicate, sodium hydroxide, hydrogenated lecithin, propylene glycol, phenoxyethanol, methylparaben, fragrance, and iron oxide).

11. The vascular wall strengthening agent according to claim 10, wherein the amount of the soy protein is 0.00001 to 2% by mass, and / or the amount of the ergothioneine is 0.0000000015 to 0.00015% by mass.

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