Agent for alleviating menstrual symptoms and use thereof

Abstract

To provide an agent for alleviating menstrual symptoms whose alleviating effect is improved; a stick-shaped agent for alleviating menstrual symptoms, comprising the agent for alleviating menstrual symptoms; and a method for alleviating menstrual symptoms using the agent for alleviating menstrual symptoms.SOLUTION: An agent for alleviating menstrual symptoms of the present invention contains, as an active ingredient, a squeezed liquid, extract, or distillate of at least one selected from the woody part and the leaves of a tree. In one example, a stick-shaped agent for alleviating menstrual symptoms 21 includes a case 23 and an oily solid 22 housed in the case 23, and the oily solid 22 contains the agent for alleviating menstrual symptoms.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a menstrual symptom reliever and its use.

Background Art

[0002] As menstrual associated symptoms, premenstrual syndrome (PMS) and dysmenorrhea related to physical and mental discomfort before and during menstruation are known. PMS is a symptom that occurs periodically from 3 to 10 days before menstruation and refers to a group of mental and physical symptoms that disappear after the start of menstruation. Examples of such symptoms include depressive state, anxiety, emotional instability, anger, listlessness, apathy, decreased concentration and a feeling of being overwhelmed or abnormal, sleep disorders, breast pain, breast swelling, a feeling of bloating, weight gain, headache, and joint pain / muscle pain. Although there are individual differences in the degree of these symptoms, when the symptoms are severe, they may interfere with work and daily life and may lead to deterioration of human relationships at home and in the workplace.

[0003] Dysmenorrhea is generally referred to as a symptom during menstruation accompanied by abnormally strong pain or systemic disorders. When dysmenorrhea occurs, it may be necessary to stay in bed or make work difficult. Dysmenorrhea is also called menstrual pain. Representative symptoms of dysmenorrhea include pain such as lower abdominal pain and low back pain, and various physical symptoms such as nausea, vomiting, diarrhea, and headache. It has a relatively high frequency of medical visits among gynecological diseases. Among the increasing opportunities for women's social advancement, there are also scholars who point out the relationship between women's labor productivity and PMS. Alleviation and reduction of menstrual-related symptoms represented by PMS and dysmenorrhea are also important social issues for improving women's QOL (Quality of Life).

[0004] Several agents for relieving premenstrual syndrome symptoms have been proposed. For example, in Patent Documents 1, 2, and 3, agents for relieving symptoms containing pharmaceutical components have been proposed respectively. However, in the use of pharmaceutical components, there are concerns about their side effects. Therefore, several agents for relieving menstrual symptoms containing specific oils or fragrances have been proposed (Patent Documents 4, 5, and 6).

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Patent Document 5

Patent Document 6

Summary of the Invention

Problems to be Solved by the Invention

[0006] However, according to the studies of the present inventors, in conventional agents for relieving menstrual symptoms, there is room for improvement in the effect of relieving menstrual symptoms. In addition, conventional agents for relieving menstrual symptoms cannot be easily used. Therefore, it is difficult to say that the agents for relieving menstrual symptoms themselves are widely popularized.

[0007] The present invention provides an agent for relieving menstrual symptoms with an improved effect of relieving menstrual symptoms, a stick-shaped agent for relieving menstrual symptoms provided with the agent for relieving menstrual symptoms, and a method for relieving menstrual symptoms using the agent for relieving menstrual symptoms.

Means for Solving the Problems

[0008] As a result of intensive studies, the inventors of the present invention have found that a squeezing liquid, extract or distillate obtained from the xylem of a tree or the leaves of a tree can be expected to improve the effect of alleviating menstrual symptoms, and have thus completed the present invention.

[0009] The present invention has the following aspects. [1] A menstrual symptom reliever containing, as an active ingredient, a squeezing liquid, extract or distillate of at least one of the xylem of a tree and the leaves of a tree. [2] The menstrual symptom reliever according to [1], wherein the squeezing liquid, the extract or the distillate is an oily component. [3] The menstrual symptom reliever according to [1] or [2], wherein the tree includes at least one tree selected from the group consisting of the genus Chamaecyparis of the family Cupressaceae, the genus Cryptomeria of the family Cupressaceae, the genus Abies of the family Pinaceae, the genus Eucalyptus of the family Myrtaceae, the genus Camphor tree of the family Lauraceae, and the genus Torreya of the family Cupressaceae. [4] The menstrual symptom reliever according to [3], wherein the tree includes a tree of the genus Abies of the family Pinaceae. [5] The menstrual symptom reliever according to any one of [1] to [4], which is used for symptoms before menstruation. [6] The menstrual symptom reliever according to any one of [1] to [5], which is used for symptoms during menstruation. [7] The menstrual symptom reliever according to any one of [1] to [6], which is used for alleviating at least one of physical symptoms and mental symptoms. [8] The menstrual symptom reliever according to [7], wherein the physical symptoms include at least one symptom selected from the group consisting of abnormal appetite, abnormal sleep, breast pain, breast swelling, a feeling of stuffiness, weight gain, headache, arthralgia, and myalgia. [9] The menstrual symptom reliever according to [7] or [8], wherein the mental symptoms include at least one symptom selected from the group consisting of a depressed state, anxiety, emotional instability, anger, listlessness, decreased concentration, and a feeling of being overwhelmed.

[10] A stick-shaped menstrual symptom reliever comprising a case and an oily solid agent accommodated in the case, wherein the oily solid agent contains the menstrual symptom reliever according to any one of [1] to [9].

[11] An aromatic agent type menstrual symptom reliever comprising a container and an aromatic agent accommodated in the container, wherein the aromatic agent contains the menstrual symptom reliever according to any one of [1] to [9].

[12] A bath agent type menstrual symptom reliever comprising a container and a bath agent stored in the container, wherein the bath agent contains the menstrual symptom reliever according to any one of [1] to [9].

[13] A method for relieving menstrual symptoms, comprising volatilizing the menstrual symptom reliever according to any one of [1] to [9].

[14] A method for relieving menstrual symptoms, comprising inhaling the menstrual symptom reliever according to any one of [1] to [9].

[15] A method for relieving menstrual symptoms, comprising continuously using the menstrual symptom reliever according to any one of [1] to [9] from 10 days before the start of menstruation until the end of menstruation.

[16] A method for relieving menstrual symptoms, comprising continuously using the menstrual symptom reliever according to any one of [1] to [9] from 5 days before the start of menstruation until the end of menstruation.

[17] A method for relieving menstrual symptoms, comprising using the menstrual symptom reliever according to any one of [1] to [9] when symptoms occur during menstruation.

[18] Step 1 of obtaining an evaluation (1) regarding menstrual symptoms before menstruation without the subject smelling the menstrual symptom reliever according to any one of [1] to [9]; Step 2 of obtaining an evaluation (2) regarding menstrual symptoms after menstruation without the subject smelling the menstrual symptom reliever according to any one of [1] to [9]; Step 3 of the subject smelling the menstrual symptom reliever according to any one of [1] to [9] before menstruation and obtaining an evaluation (3) regarding menstrual symptoms; Step 4 of discriminating the presence or absence of the onset of premenstrual syndrome by comparing the evaluation (1) obtained in Step 1 and the evaluation (2) obtained in Step 2; Step 5 of comparing the evaluation (1) and the evaluation (3) obtained from the subjects in whom the onset of premenstrual syndrome was recognized in the step 4; An evaluation method for the menstrual symptom alleviating effect, comprising:

[19] The evaluation method according to

[18] , wherein in each of the step 1, the step 2, the step 3, the step 4, and the step 5, an evaluation is obtained on or after the start of menstruation or at least on the first day or more counted from the start of menstruation.

[20] A first output unit that outputs at least once a question regarding menstrual symptoms from after a lapse of a certain period from the previous menstruation to the next menstruation; a first acquisition unit that obtains an answer before menstruation without smelling the menstrual symptom alleviating agent described in any one of [1] to [9] for the question; a second output unit that outputs at least once a question regarding menstrual symptoms from after a lapse of a certain period from the start of menstruation to a certain period; a second acquisition unit that obtains an answer after menstruation without smelling the menstrual symptom alleviating agent described in any one of [1] to [9] for the question; a third output unit that outputs at least once a question regarding menstrual symptoms from after a lapse of a certain period from the previous menstruation to the next menstruation; a third acquisition unit that smells the menstrual symptom alleviating agent described in any one of [1] to [9] for the question and obtains an answer before menstruation; a first determination unit that determines the presence or absence of the onset of premenstrual syndrome by comparing the answer of the first acquisition unit and the answer of the second acquisition unit; a second determination unit that determines the improvement of menstrual symptoms by the menstrual symptom alleviating agent by comparing each answer of the first acquisition unit and the third acquisition unit obtained from the subjects in whom the onset of premenstrual syndrome was recognized by the first determination unit; and an output unit that outputs the result determined by the second determination unit. A menstrual symptom improvement determination system.

Effect of the Invention

[0010] According to the present invention, it is possible to provide a menstrual symptom alleviating agent with an improved menstrual symptom alleviating effect, a stick-shaped menstrual symptom alleviating agent including the menstrual symptom alleviating agent, and a menstrual symptom alleviating method using the menstrual symptom alleviating agent.

Brief Description of the Drawings

[0011]

Figure 1

Figure 2

Figure 3

Mode for Carrying Out the Invention

[0012] In this specification, a numerical range represented by "~" means a range including the numerical values described before and after "~" as the lower limit value and the upper limit value. For example, "A~B%" means A% or more and B% or less.

[0013] The menstrual symptom reliever of the present invention contains, as an active ingredient, at least one of a squeezed liquid, an extract, or a distillate of the xylem of a tree and the leaves of a tree. Hereinafter, some representative embodiments of the menstrual symptom reliever will be described. The following description relates to representative examples of the embodiments, and the embodiments of the present invention are not limited to the following description.

[0014] [Active Ingredient] The tree is not particularly limited, and examples thereof include trees of the genus Chamaecyparis of the family Cupressaceae, the genus Cryptomeria of the family Cupressaceae, the genus Cunninghamia of the family Cupressaceae, the genus Cryptomeria of the family Cupressaceae, the genus Abies of the family Pinaceae, the genus Picea of the family Pinaceae, the genus Tsuga of the family Pinaceae, the genus Pinus of the family Pinaceae, the genus Larix of the family Pinaceae, the genus Pseudotsuga of the family Pinaceae, the genus Eucalyptus of the family Myrtaceae, the genus Eurya of the family Pentaphylacaceae, the genus Castanopsis of the family Fagaceae, and the genus Chamaecyparis of the family Cupressaceae. The trees may be used alone or in combination of two or more.

[0015] Examples of trees of the genus Chamaecyparis of the family Cupressaceae include Chamaecyparis obtusa, Chamaecyparis formosensis, Chamaecyparis pisifera, Chamaecyparis lawsoniana, Chamaecyparis thyoides, Chamaecyparis nootkatensis, Chamaecyparis obtusa var. wilsonii, Chamaecyparis obtusa var. formosana, Chamaecyparis obtusa var. sieboldii, Chamaecyparis obtusa var. wilsonii f. aurea, Chamaecyparis obtusa var. formosana f. aurea, Chamaecyparis obtusa var. sieboldii f. aurea, and Chamaecyparis obtusa var. wilsonii f. glauca. Examples of trees of the genus Cryptomeria of the family Cupressaceae include Cryptomeria japonica and Cryptomeria fortunei. Examples of trees in the genus Chamaecyparis of the family Cupressaceae include Chamaecyparis obtusa var. formosana, Chamaecyparis pisifera Sieb. et Zucc., Chamaecyparis lawsoniana Parl., and Chamaecyparis taiwanensis. Examples of trees in the genus Cryptomeria of the family Cupressaceae include Cryptomeria japonica D. Don, Cryptomeria japonica var. sinensis, Cryptomeria japonica var. araucarioides, Cryptomeria japonica var. yosemitensis, Cryptomeria japonica cv. Aurea, Cryptomeria japonica cv. Sekka, and Cryptomeria japonica cv. Midori.

[0016] Examples of trees in the genus Abies of the family Pinaceae include Abies sachalinensis Masters, Abies firma Sieb. et Zucc., Abies mariesii Mast., Abies veitchii Lindl., Abies grandis (Douglas ex D. Don) Lindl., Abies beshanzuensis M. H. Wu, and Abies nephrolepis (Trautv.) Maxim. Examples of trees in the genus Eucalyptus of the family Myrtaceae include Eucalyptus globulus Labill., Eucalyptus gunnii Hook., Eucalyptus camaldulensis Dehnh., and Eucalyptus citriodora Hook. Examples of trees in the genus Castanopsis of the family Fagaceae include Castanopsis cuspidata (Thunb.) Schottky. Examples of trees in the genus Torreya of the family Taxaceae include Torreya nucifera (L.) Sieb. et Zucc. Examples of trees in the genus Thujopsis of the family Cupressaceae include Thujopsis dolabrata (L. f.) Sieb. et Zucc., Thujopsis sutchuenensis Franch., Thujopsis dolabrata var. hondai (Nakai) H. Ohashi, and Thujopsis dolabrata var. lanceolata (Sieb. ex Endl.) H. Ohashi.

[0017] Among them, due to their wide distribution in Japan and easy availability, the genera Chamaecyparis, Cryptomeria, Abies, Eucalyptus, Castanopsis, and Thujopsis of the family Cupressaceae are preferred, and the genus Abies of the family Pinaceae is more preferred. Among the trees of the genus Chamaecyparis of the family Cupressaceae, Chamaecyparis obtusa Sieb. et Zucc., Chamaecyparis formosensis Matsum., and Chamaecyparis taiwanensis are preferred. Among the trees of the genus Cryptomeria of the family Cupressaceae, Cryptomeria japonica D. Don is preferred. Among the trees of the genus Abies of the family Pinaceae, Abies sachalinensis Masters and Abies firma Sieb. et Zucc. are preferred. Among the trees of the genus Eucalyptus of the family Myrtaceae, Eucalyptus globulus Labill. is preferred. Among the trees of the genus Castanopsis of the family Fagaceae, Castanopsis cuspidata (Thunb.) Schottky is preferred. Among the trees of the genus Thujopsis of the family Cupressaceae, Thujopsis dolabrata (L. f.) Sieb. et Zucc. is more preferred. Among them, Abies sachalinensis Masters of the genus Abies of the family Pinaceae is particularly preferred.

[0018] As raw materials for trees, from the perspective of effective utilization of resources, thinned trees and pruned trees are preferred. Also, in terms of having a high menstrual symptom alleviating effect, the leaves of the trees are preferred. The leaf part may be used as it is, but preferably it is used after being crushed or ground by a crusher, a grinder, or the like.

[0019] A pressing liquid, an extract, or a distillate can be obtained from the xylem of the tree, the whole or a part of the leaves of the tree. The pressing liquid, the extract, or the distillate is preferably an oily component. The distillate is preferred in that a menstrual symptom reliever with a high alleviating effect is easily obtained.

[0020] The pressing liquid can be produced using various presses. The press is not particularly limited. The method for producing the extract is not particularly limited either and can be produced according to a conventional method. As the extraction solvent, a polar solvent is preferred. Examples of the polar solvent include aqueous solvents such as water; alcohol solvents such as ethanol, methanol, butyl alcohol, ethylene glycol, propylene glycol, and glycerin; halogen-containing solvents such as chloroform; ether solvents such as dioxane; and carbonyl solvents such as acetone and ethyl acetate. The polar solvent may be used alone or in combination of two or more. The distillation method for obtaining the distillate is not particularly limited. Various distillation methods such as atmospheric distillation, vacuum distillation, and steam distillation can be used.

[0021] As the distillate, that obtained by heating distillation under reduced pressure conditions is preferred. For heating distillation, a heater may be used, but heating using microwaves is preferred. In particular, it is preferred to irradiate microwaves without adding water. By irradiating microwaves without adding water, the water molecules in the tree are directly heated to generate water vapor. When this water vapor acts as the mobile phase, the volatile components in the tree can also be distilled. Therefore, it is considered that the distillate obtained by heating distillation using microwaves under reduced pressure conditions contains a component similar to vacuum distillation separated by the difference in the boiling points of the volatile components and a component similar to steam distillation separated by the difference in the mobile phase.

[0022] The distillate obtained by heating distillation using microwaves under reduced pressure conditions can be obtained, for example, by using the apparatus shown in FIG. 1. The microwave distillation apparatus 1 shown in FIG. 1 includes a distillation tank 2, a microwave heating apparatus 3, a stirring paddle 4, an air flow inlet pipe 5, a distillate outlet pipe 6, a cooling apparatus 7, a heating control apparatus 8, a vacuum pump 9, a pressure regulating valve 10, and a pressure control apparatus 11.

[0023] According to the microwave distillation apparatus 1, a distillate 13 is obtained from the distillation target 12. First, the distillation target 12, that is, at least one of the xylem of the raw material tree and the leaves of the tree, is placed in the distillation tank 2. Then, while stirring the raw material with the stirring paddle 4, microwaves are radiated from the microwave heating apparatus 3 disposed on the upper surface of the distillation tank 2 to heat the raw material.

[0024] Near the bottom surface of the distillation tank 2, an opening at one end of the air flow inlet pipe 5 is disposed. The air flow inlet pipe 5 is for introducing an inert gas such as air or nitrogen into the distillation tank 2. The air flow of the inert gas is introduced from the lower part of the distillation tank 2. Further, the distillate outlet pipe 6 is for leading out the distillate from the heated raw material to the outside from the upper part of the distillation tank 2. An opening at one end of the distillate outlet pipe 6 is disposed above the distillation tank 2.

[0025] As the gas introduced into the distillation tank 2, air may be used, but inert gases such as nitrogen gas, helium gas, and argon gas are preferred. As for the flow rate, the flow rate per minute may be about 0.001 times to 0.1 times the volume of the distillation tank 2.

[0026] A temperature sensor and a pressure sensor (not shown in the figure) are attached to the distillation tank 2. The temperature and pressure can be measured by these sensors. The temperature and pressure of the distillation tank 2 can be adjusted by the heating control apparatus 8, the vacuum pump 9, the pressure regulating valve 10, and the pressure control apparatus 11.

[0027] The gaseous distillate flowing out from the distillation tank 2 through the distillation product outlet pipe 6 is changed into a liquid by the cooling device 7 and becomes the distillate 13. This distillate 13 contains an oily fraction 13a and an aqueous fraction 13b. Among these, the oily fraction 13b is more suitable for the menstrual symptom reliever.

[0028] The pressure in the distillation tank 2 during distillation is preferably 1 to 95 kPa, more preferably 5 to 60 kPa, and even more preferably 10 to 40 kPa, but is not particularly limited. The vapor temperature at that time is from 40°C to 100°C. If the pressure is 1 kPa or more, the increase in the vapor pressure of the volatile components in the tree is likely to be promoted. Also, the components of steam distillation are likely to be relatively more than the components of vacuum distillation according to the boiling points of each component. As a result, since they are likely to flow out in order from the ones with higher boiling points, the components with boiling points higher than water are efficiently extracted. If the pressure is 95 kPa or less, it is easy to suppress energy loss. Also, oxidation of the raw material is easy to suppress. The distillation time is preferably about 0.2 to 8 hours, and more preferably about 0.4 to 6 hours. If the distillation time is 0.2 hours or more, it is difficult for unextracted components to remain in the tree. If the distillation time is 8 hours or less, the extraction efficiency is difficult to decrease.

[0029] In the distillation tank 2, a tree distillation residue from which at least a part of the oil and water has been removed from the raw material by distillation remains. This distillation residue may be reused as an extraction raw material. That is, an extraction treatment may be performed using the residual residue after the distillation treatment as an extraction raw material. Examples of the extraction solvent used here include the same ones as those described above. Aqueous solvents such as water, ethanol, and 3-methyl-3-methoxy-1-butanol are preferred. The above-mentioned aqueous fraction 13b is also preferably used as an extraction solvent.

[0030] It is also possible to obtain a further distillate by adding water or the aqueous fraction 13b to the distillation residue and then performing distillation under reduced pressure or normal pressure. Details of this are disclosed as a method for obtaining a second essential oil in Japanese Patent Laid-Open No. 2021-181508. The second essential oil obtained from the following steps (a) to (d) is also suitable for the menstrual symptom reliever.

[0031] (a) Heating at least one of the xylem of a tree and the leaves of the tree by microwave under reduced pressure, distilling with the moisture contained in the tree, and separating a first fibrous component from which at least a part of the oil and moisture has been removed by distillation and a first distillate. (b) Separating a first essential oil and a first refined water from the first distillate obtained in step (a). (c) Adding at least one of water and the first refined water obtained in step (b) to the first fibrous component obtained in step (a), heating by microwave under reduced pressure or normal pressure, and separating a second fibrous component from which at least a part of the oil and moisture has been further removed by distillation and a second distillate. (d) Separating a second essential oil and a second refined water from the second distillate obtained in step (c).

[0032] In the above steps (a) to (d), when the tree is a larch, the second essential oil contains relatively more monoterpene components such as bornyl acetate and borneol, and sesquiterpenes such as caryophyllene. The content of terpene components with a boiling point of 200 °C or higher is 40% by mass or more, preferably 45% by mass or more.

[0033] The squeezed juice, extract or distillate may be used as it is, may be further concentrated or purified as necessary. The squeezed juice, extract or distillate may be used as it is as a menstrual symptom reliever, or may be further blended with a suitable solvent. For example, solvents such as water, ethanol, isopropyl alcohol, propyl alcohol, propylene glycol, ethylene glycol, ethylene glycol monomethyl ether, propylene glycol monomethyl ether, propylene alcohol monoethyl ether, 3-methoxy-3-methyl-1-butanol can be used. By blending with a solvent so that the concentration of the active ingredient amount is about 0.01 to 99% by mass, a menstrual symptom reliever can be prepared.

[0034] [Use] According to the menstrual symptom reliever of the present invention, various symptoms related to menstruation can be relieved. The menstrual symptom reliever may be used for the purpose of relieving premenstrual symptoms, may be used for the purpose of relieving symptoms during menstruation, or may be used both before and during menstruation. The symptoms may be physical symptoms, may be mental symptoms, or may be both physical and mental symptoms.

[0035] Examples of physical symptoms include abnormal appetite, abnormal sleep, breast pain, breast swelling, a feeling of bloating, weight gain, headache, joint pain, and muscle pain. Examples of mental symptoms include depression, anxiety, mood instability, anger, fatigue, decreased concentration, and a feeling of being overwhelmed. However, menstrual symptoms are not limited to these examples.

[0036] The menstrual symptom reliever can be used for the purpose of reducing symptoms related to menstruation by applying it to fragrances, foods, cosmetics, quasi-drugs, pharmaceuticals, and daily necessities. Also, it can be used for the same purpose by applying the menstrual symptom reliever to the living space or articles.

[0037] For example, by blending a menstrual symptom reliever into common food ingredients, a food containing the menstrual symptom reliever can be produced. Beverage forms such as drinks, candies, troches, chewing gums, etc. are preferred as the food.

[0038] Examples of cosmetics containing the menstrual symptom reliever include soaps, shampoos, bath salts, perfumes, eau de parfum, colognes, creams, lotions, body lotions, body powders, body creams, hand creams, body washes, massage oils, hair creams, hair lotions, and hair sprays. The perfume may be a spray perfume or a roll-on perfume, and is not particularly limited.

[0039] For example, by using a pharmaceutically acceptable carrier according to a conventional method, the menstrual symptom reliever can be formulated into various forms to produce pharmaceuticals or quasi-drugs. Forms of pharmaceuticals or quasi-drugs include, for example, tablets, powders, capsules, syrups, liquids, sublingual tablets, troches, mouthwashes, oral cooling agents, gargles, nasal drops, sprays, throat sprays, toothpastes, and dispersants, but are not limited thereto. The dosage of the pharmaceutical may be appropriately set according to the administration purpose, the age of the patient, and the symptoms.

[0040] Daily necessities containing a menstrual symptom reliever are not particularly limited, and examples include dispersants, fragrances, deodorants, fragrance deodorants, and additives to the water of humidifiers. In addition, fiber products impregnated with a menstrual symptom reliever are also included. Examples of fiber products include masks, gauze, bandages, towels, handkerchiefs, towels, tissues, wet tissues, gloves, underwear, white coats, surgical gowns, diapers, sanitary products, bedding (futons, pillows, sheets, pillowcases, nightgowns), and pillow mists.

[0041] A fragrance may be blended into the menstrual symptom reliever. Examples of fragrance components include animal-derived fragrances such as musk, civet, and ambergris; plant-derived fragrances such as Abies oil, action oil, almond oil, angelica root oil, pageil oil, bergamot oil, perch oil, boabarrow oil, kaya buti oil, gananga oil, capsicum oil, caraway oil, cardamom oil, cassia oil, celery oil, cinnamon oil, citronella oil, cognac oil, coriander oil, cumin oil, camphor oil, basil oil, estogolan oil, eucalyptus oil, fennel oil, garlic oil, ginger oil, grapefruit oil, hop oil, lemon oil, lemongrass oil, nutmeg oil, mandarin oil, peppermint oil, orange oil, sage oil, star anise oil, terpine oil, rosemary oil, eucalyptus oil, anise oil, lavender oil, cumin oil, cinnamon oil, hinoki oil, etc.

[0042] As a fragrance, artificial fragrances such as synthetic fragrances and extracted fragrances can also be used. For example, hydrocarbon-based fragrances such as α-pinene, β-pinene, limonene, α-farnesene, β-farnesene, γ-terpinene, etc., alcohol-based fragrances such as linalool, geraniol, citronellol, nerol, ethyl linalool, borneol, benzyl alcohol, anisyl alcohol, β-phenethyl alcohol, florosa, etc., phenol-based fragrances such as eugenol, aldehyde-based fragrances such as n-butyl aldehyde, isobutyl aldehyde, hexyl aldehyde, citral, citronellal, benzaldehyde, cinnamic aldehyde, hexyl cinnamic aldehyde, etc., ketone-based fragrances such as neral, geranial, carvone, menthone, camphor, acetophenone, ionone, etc., lactone-based fragrances such as γ-butyrolactone, coumarin, cineole, etc., ester-based fragrances such as linalyl acetate, octyl acetate, bornyl acetate, benzyl acetate, cinnamyl acetate, butyl propionate, methyl benzoate, etc. Surfactants and hydrotropes may be used as necessary.

[0043] [Usage Method] In one example, a method for relieving menstrual symptoms includes volatilizing a menstrual symptom reliever. By volatilizing the menstrual symptom reliever in space, the active ingredient of the menstrual symptom reliever can be inhaled, so that a relieving effect on menstrual symptoms can be obtained. In another example, a method for relieving menstrual symptoms includes inhaling a menstrual symptom reliever.

[0044] For example, it may be used by volatilizing or spraying a spraying agent, fragrance, deodorant, fragrance deodorant, etc. into the air. It is an advantage that it can impart a relieving effect on menstrual symptoms to the daily living space. The volatilization method and spraying method are not particularly limited, but examples include a method of volatilizing the menstrual symptom reliever as it is, a method of volatilizing it using a volatilization device, a method using an atomization device such as a pump spray, aerosol, ultrasonic vibrator, pressurized liquid spray or pressurized air atomizing spray device. The menstrual symptom reliever may be volatilized using a diffuser.

[0045] The amount of the active ingredient during use may be appropriately changed depending on the purpose of administration and the dosage form, as long as it is an amount sufficient to obtain a sufficient effect of relieving discomfort symptoms by inhalation. For example, in the case of a room fragrance, the active ingredient is preferably 0.05 to 20% by mass. As for the concentration of the volatilized component, 1 to 4000 μg / m 3 is preferable, 10 to 2000 μg / m 3 is more preferable, and 20 to 1000 μg / m 3 is even more preferable.

[0046] In one example, a method for relieving menstrual symptoms includes continuously using a menstrual symptom reliever from 10 days before the start of menstruation until during menstruation. In another example, a method for relieving menstrual symptoms includes continuously using a menstrual symptom reliever from 5 days before the start of menstruation until during menstruation. In yet another example, a method for relieving menstrual symptoms includes using a menstrual symptom reliever when symptoms occur during menstruation.

[0047] [Stick-shaped menstrual symptom reliever] The stick-shaped menstrual symptom reliever includes a case and an oily solid agent housed in the case. The oily solid agent contains a menstrual symptom reliever.

[0048] In one example, the oily solid agent further contains various waxes in addition to the menstrual symptom reliever. Examples of the wax include synthetic wax, polyethylene, neopentyl glycol dicaprate, methyl polymethacrylate, isopropyl myristate, triethylhexanoin, and dimethicone.

[0049] The oily solid agent may further contain other components such as a fragrance and a filler as needed. Examples of the fragrance include the same fragrances as those described above. The filler may be an inorganic filler or an organic filler, and is not particularly limited.

[0050] The case of the stick-shaped menstrual symptom reliever is not particularly limited as long as it can accommodate the oily solid agent, and a cylindrical case can be mentioned. The cross-sectional shape of the case is also not particularly limited and can be arbitrarily set according to the shape of the oily solid agent. The case may be able to feed out the oily solid agent during use, or may be provided with a cap for protecting the oily solid agent when not in use.

[0051] An example of the stick-shaped menstrual symptom reliever is shown in Fig. 2. The stick-shaped menstrual symptom reliever 21 shown in Fig. 2 includes a case 23 and an oily solid agent 22 accommodated in the case 23. The oily solid agent 22 contains the menstrual symptom reliever. When using the stick-shaped menstrual symptom reliever 21, the oily solid agent 22 is fed out above the opening surface of the case 23 as shown in Fig. 2. Thereafter, by directly inhaling the fragrance, inhaling the fragrance volatilized from the oily solid agent 22 applied to the wrist or the like, or inhaling the fragrance of the oily solid agent 22 applied to a mask or the like during breathing, a menstrual symptom relieving effect can be obtained. After use, the oily solid agent 22 may be stored below the opening surface of the case 23, or may be covered with a cap (not shown).

[0052] [Fragrance-type menstrual symptom reliever] The fragrance-type menstrual symptom reliever includes a container and a fragrance accommodated in the container. The fragrance contains the menstrual symptom reliever.

[0053] In one example, the fragrance may further contain various solvents and surfactants in addition to the menstrual symptom reliever. Examples of the solvent include water, ethanol, isopropyl alcohol, propyl alcohol, propylene glycol, ethylene glycol, ethylene glycol monomethyl ether, propylene glycol monomethyl ether, propylene alcohol monoethyl ether, and 3-methoxy-3-methyl-1-butanol. As the surfactant, various nonionic surfactants, cationic surfactants, anionic surfactants, and amphoteric surfactants can be used.

[0054] The fragrance agent may further contain other components such as fragrances, deodorants, and pigments as needed. Examples of the fragrances include the same fragrances as those described above. The fragrance agent may be in liquid form, gel form, or solid form.

[0055] When using the fragrance agent type menstrual symptom reliever, after directly placing it in a living space or using an appropriate diffuser or nebulizer to disperse it into the space and then inhaling the dispersed fragrance, a menstrual symptom relief effect can be obtained.

[0056] [Bath agent type menstrual symptom reliever] The bath agent type menstrual symptom reliever includes a container and a bath agent stored in the container. The bath agent contains a menstrual symptom reliever. The bath agent may be in powder form, tablet form, or liquid form. The bath agent is put into the bathtub during bathing. By inhaling the fragrance volatilized from the hot water, a menstrual symptom relief effect can be obtained.

[0057] In one example, the bath agent contains various components in addition to the menstrual symptom reliever. For example, sodium carbonate, sodium bicarbonate, sodium sulfate, sodium chloride, magnesium sulfate, and titanium oxide can be mentioned. In the case of a liquid bath agent, for example, 1,3 - butylene glycol, liquid paraffin, glycerin, ethanol, purified water, and surfactants can be mentioned.

[0058] The bath agent may further contain other components such as fragrances, moisturizers, and essential oils as needed. Examples of the fragrances include the same fragrances as those described above.

[0059] [Method for evaluating menstrual symptom relief effect] In one example, the method for evaluating the menstrual symptom relief effect includes the following Step 1, Step 2, Step 3, Step 4, and Step 5. · Step 1: A step of obtaining an evaluation (1) regarding menstrual symptoms before menstruation without the subject smelling the menstrual symptom reliever. · Step 2: A step of obtaining an evaluation (2) regarding menstrual symptoms after menstruation without the subject smelling the menstrual symptom reliever. · Step 3: A step in which the subject smells a menstrual symptom reliever before menstruation and obtains an evaluation (3) regarding menstrual symptoms. · Step 4: A step of determining the presence or absence of the onset of premenstrual syndrome by comparing the evaluation (1) obtained in Step 1 with the evaluation (2) obtained in the above Step 2. · Step 5: A step of comparing the evaluation (1) and the evaluation (3) obtained from the subject in whom the onset of premenstrual syndrome was recognized in Step 4.

[0060] Regarding the evaluation (1) regarding menstrual symptoms, the evaluation (2) regarding menstrual symptoms, and the evaluation (3) regarding menstrual symptoms, the evaluation items are not particularly limited. Evaluation can be performed from each of physical symptoms and mental symptoms. For example, as in the examples described later, the Japanese version of DRSP (Dairy Records of Severity of Problems) may be used.

[0061] The method for obtaining the evaluation (1) regarding menstrual symptoms, the evaluation (2) regarding menstrual symptoms, and the evaluation (3) regarding menstrual symptoms is not particularly limited. A smartphone, a personal computer, or a tablet terminal may be used, or it may be obtained by an app or a web questionnaire.

[0062] Regarding the evaluation acquisition period, in each of Step 1, Step 2, Step 3, Step 4, and Step 5, it is preferable to obtain an evaluation starting from before menstruation or at least on the first day or more since the start of menstruation.

[0063] As the subject, it is preferable to satisfy at least one of the following conditions, and most preferably to satisfy all of them. · Being a woman aged 20 - 45 years old. · Having had menstruation within the past year and having mental symptoms such as being irritable or feeling anxious during the past year. ·The degree of symptoms falls into one of the five levels: "so troubled that unable to do any work, housework, study, etc.", "very troubled", "somewhat troubled", "not troubled", "no symptoms", and corresponds to either "very troubled" or "somewhat troubled". ·The menstrual cycle is stable at about 25 to 35 days. ·Not currently pregnant and having no recent plan to get pregnant. ·Not taking medications or supplements for the purpose of improving premenstrual symptoms. However, taking analgesics is allowed. ·Never been diagnosed with "depression" or "depressive state" from the past to the present. ·Not under treatment in a psychiatric department or psychosomatic medicine department. ·Having the intention to use stick perfume.

[0064] The method of comparing evaluations is not particularly limited. For example, the average values of evaluation scores may be compared, or various other statistical methods may be used.

[0065] [Menstrual Symptom Improvement Judgment System] For the evaluation of the menstrual symptom alleviating effect, the following improvement determination system for menstrual symptoms is also useful. According to one aspect of the present invention, a first output unit that outputs at least one question regarding menstrual symptoms at least once from a certain period after the previous menstruation until the next menstruation, a first acquisition unit that acquires answers before menstruation without smelling a menstrual symptom reliever for the question, a second output unit that outputs at least one question regarding menstrual symptoms at least once from a certain period after the start of menstruation until a certain period, a second acquisition unit that acquires answers after the end of menstruation without smelling a menstrual symptom reliever for the question, a third output unit that outputs at least one question regarding menstrual symptoms at least once from a certain period after the previous menstruation until the next menstruation, a third acquisition unit that smells a menstrual symptom reliever and acquires answers before menstruation for the question, a first determination unit that determines the presence or absence of the onset of premenstrual syndrome by comparing the answer of the first acquisition unit with the answer of the second acquisition unit, and a second determination unit that determines the improvement of menstrual symptoms by the menstrual symptom reliever by comparing each answer of the first acquisition unit and the third acquisition unit acquired from a subject in whom the onset of premenstrual syndrome is recognized by the first determination unit, and an output unit that outputs the result determined by the second determination unit, and an improvement determination system for menstrual symptoms is provided.

[0066] Conventionally, the answers of subjects for the evaluation of the menstrual symptom alleviating effect were often obtained on paper using a questionnaire. However, in the case of paper, since it is necessary to manage the answers by oneself, daily answers are essential to prevent forgetting the answers due to confusion about the answer date. In addition, since the menstrual cycle cannot be predicted, daily answers using a questionnaire were important.

[0067] On the other hand, according to the improvement determination system for menstrual symptoms, by using the second output unit that outputs at least one question regarding menstrual symptoms at least once from a certain period after the start of menstruation until a certain period, answer data can be obtained using a mechanism in which a questionnaire is automatically distributed every day from 6 days to 10 days after the start of menstruation. More specifically, by registering the start date of menstruation, answer data can be obtained using a mechanism in which a questionnaire is automatically distributed every day from 6 days to 10 days after the start of menstruation and from a certain period after the previous menstruation until the next menstruation.

[0068] For example, response data can be obtained by a smartphone, a personal computer, a tablet terminal, an app, or a web questionnaire. Therefore, the burden on the subject can be reduced.

[0069] The menstrual symptom improvement determination system according to the preferred example includes a first output unit that outputs questions regarding menstrual symptoms at least 3 days or more, preferably 5 days or more, from 15 to 18 days after the previous menstruation until the day before the next menstruation every month.

[0070] The menstrual symptom improvement determination system according to the preferred example includes a first acquisition unit that acquires responses before menstruation without smelling a menstrual symptom reliever for questions regarding menstrual symptoms.

[0071] The menstrual symptom improvement determination system according to the preferred example includes a second output unit that outputs questions regarding menstrual symptoms at least 3 days, preferably 5 days, after 6 days have passed since the start of menstruation every month.

[0072] The menstrual symptom improvement determination system according to the preferred example and a second acquisition unit that acquires responses after menstruation without smelling a menstrual symptom reliever for questions regarding menstrual symptoms.

[0073] The menstrual symptom improvement determination system according to the preferred example includes a third output unit that outputs questions regarding menstrual symptoms at least 3 days or more, preferably 5 days or more, from 15 to 18 days after the previous menstruation until the day before the next menstruation every month.

[0074] The menstrual symptom improvement determination system according to the preferred example includes a third acquisition unit that smells a menstrual symptom reliever and acquires responses before menstruation for questions regarding menstrual symptoms.

[0075] The menstrual symptom improvement determination system according to the preferred example includes a first determination unit that determines the presence or absence of the onset of premenstrual syndrome by comparing the response of the first acquisition unit with the response of the second acquisition unit.

[0076] The menstrual symptom improvement determination system according to a preferred example includes a second determination unit that determines the improvement of menstrual symptoms by the menstrual symptom reliever by comparing each response of the first acquisition unit and the third acquisition unit, which is acquired from a subject in whom the onset of premenstrual syndrome is recognized by the first determination unit.

[0077] According to the menstrual symptom improvement determination system described above, the following advantages can be provided. · Since the response date can be limited by predicting five days before the next menstruation from the previous menstruation, the burden of response can be reduced. · Since it becomes possible to confirm the response date, it becomes possible to determine whether the response was made daily or in a lump, and the reliability of the data is improved. · Aggregation of response results in real time becomes easy. · Since it can be distributed to a terminal that is always carried, there is no need for the subject to carry a response sheet. Also, the subject can respond anywhere.

[0078] As described above, several embodiments have been described, but each embodiment is presented as an example and does not limit the scope of the present invention. Each embodiment described in this specification can be variously modified within the range where the effects of the invention are achieved, and can be combined with the features described in other embodiments within the practicable range.

Example

[0079] Hereinafter, the present invention will be described in more detail using examples. However, the present invention is not limited to the description of the following examples.

[0080] [Extraction of active ingredient] The leaves of Abies sachalinensis were crushed using a compression crusher (manufactured by KYB Corporation). Approximately 50 kg of the crushed material was used as a raw material and introduced into the distillation tank 2 of the microwave distillation apparatus 1 shown in Fig. 1. While stirring, the pressure inside the distillation tank 2 was maintained under a reduced pressure condition of approximately 20 KPa. The steam temperature was approximately 67°C. By irradiating with microwaves for 1 hour, a distillate 13 was obtained. The oily fraction (hereinafter referred to as "Abies sachalinensis essential oil") was separated. The amount of the separated Abies sachalinensis essential oil was 180 mL, and the ratio to the input sample was 0.34 mass%.

[0081] [Preparation of Stick-shaped Menstrual Symptom Reliever] The stick-shaped menstrual symptom reliever 21 shown in Fig. 2 was prepared. First, components other than Abies sachalinensis essential oil and fragrance among the raw materials of the oily solid agent 22 were mixed and then heated and melted. Thereafter, Abies sachalinensis essential oil and lavender fragrance were added. After pouring the melt into a mold and cooling, a stick-shaped oily solid agent 21 was obtained. By mounting the oily solid agent 21 in a case 23 from which it could be drawn out, the stick-shaped menstrual symptom reliever 21 was obtained. The preparation of the oily solid agent 21 and the production of the stick-shaped menstrual symptom reliever 21 were entrusted to a cosmetics manufacturer with which there was a business partnership.

[0082] [Selection of Subjects] Persons who satisfied the following nine conditions were used as subjects. · Being a woman aged 20 - 45 years old. · Having had a menstrual period within the past year and having mental symptoms such as becoming irritable or anxious during the past year. · The degree of symptoms corresponding to either "so troubled that unable to do any work, housework, study, etc.", "very troubled", "somewhat troubled", "not troubled", or "no symptoms", being either "very troubled" or "somewhat troubled". · The menstrual cycle being stable at about 25 - 35 days. · Not currently pregnant and having no recent plan to become pregnant. · Not taking medications or supplements for the purpose of improving premenstrual symptoms. However, taking analgesics was permitted. · Never been diagnosed with "depression" or "depressive state" from the past to the present. · Not currently under treatment in a psychiatric or psychosomatic medicine department. · Intention to use stick perfume.

[0083] [Evaluation method] Premenstrual symptoms were evaluated using the Japanese version of DRSP (Dairy Records of Severity of Problems). The details of the Japanese version of DRSP are as described in Takeda, T. et al. Int J Womens Health. 13, 361 - 367, 2021.

[0084] In this example, in order to reduce the burden on the subjects, the evaluation was conducted only during a certain period before and after menstruation. The response period of DRSP is shown in Table 1 and Figure 3.

[0085]

Table 1

[0086] As shown in Table 1 and Figure 3, in order to compare the DRSP scores during the sample non - use period and the use period, the sample was not used during the pre - menstrual periods of the first and second cycles, and the use of the sample was started from the pre - menstrual periods of the third and fourth cycles. In order to determine whether the subject has premenstrual symptoms, the DRSP scores after menstruation were also obtained. The pre - menstrual scores were obtained from the 18th day to the day before the start of menstruation, with the start of menstruation as the first day. After menstruation, the scores for 5 days from the 6th day to the 10th day were obtained, with the start of menstruation as the first day.

[0087] The DRSP consists of questions regarding 21 mental and physical symptoms and three social impairments. Each is evaluated on a six-point scale (0: no symptoms, 1: very mild, 2: mild, 3: moderate, 4: severe, 5: very severe). Each question is shown in Table 2. Each question was divided into 15 categories and analyzed separately. In Table 2, Mood represents mental symptoms, Physical represents physical symptoms, and Social is an indicator of the degree to which premenstrual symptoms affect social life. I represents depression, II represents anxiety, III represents emotional instability, IV represents anger, V represents decreased interest, VI represents decreased concentration, VII represents lethargy, VIII represents overeating and picky eating, IX represents sleep disorders, X represents a feeling of being overwhelmed, and XI represents physical symptoms.

[0088]

Table 2

[0089] The "LINE" smartphone app was used for the DRSP. Questions were distributed on the days when answers were required, and answers were obtained. Using the results of the DRSP, comparisons were made between the sample usage period and the non-usage period, and between the effects with and without hinoki essential oil.

[0090] [Method of using the sample] The following two were prepared as samples. Example 1: A stick-shaped menstrual symptom reliever containing hinoki essential oil. Comparative Example 1: A stick-shaped menstrual symptom reliever not containing hinoki essential oil. Subjects were asked to use each sample starting from the first day of DRSP responses in the third cycle. Use of the sample during the DRSP response periods of the third and fourth cycles was mandatory, and use during other periods was optional. The samples were used by directly applying them to an arbitrary location (inside the wrist, neck muscles, chest, disposable mask, etc.) or directly smelling the product. The number of uses per day was required to be about 4 times.

[0091] [Analysis method] Among the subjects, those who answered about DRSP for 4 or more days each during the 5 days before menstruation (-5th day to -1st day) and the 5 days after menstruation (6th day to 10th day), and who did not take any medications or supplements (except analgesics) during the test period were defined as valid responders. Among the valid responders, those whose average value of the target category decreased by 30% or more after menstruation compared to before menstruation were judged to have premenstrual symptoms and were included in the analysis subjects. More specifically, first, scores were calculated using the following formula with the average values of each category.

[0092]

Number

[0093] For calculating the scores obtained by the above formula, the average values for 4 or 5 days each before and after menstruation were used. The average values for two cycles of each period were used. When the score value was 30% or more, it was judged to have premenstrual symptoms and was included in the analysis subjects. Among the analysis subjects, the improvement rates of premenstrual symptoms were determined for 15 subjects who used the sample of Example 1 and 16 subjects who used the sample of Comparative Example 1.

[0094]

Number

[0095] [Results] The measurement results of the improvement rates are shown in the following table.

[0096]

Table 3

[0097]

Table 4

[0098]

Table 5

[0099] From the above results, it was confirmed that a menstrual symptom reliever with an improved menstrual symptom relief effect can be provided. In particular, the stick-shaped menstrual symptom reliever is highly useful because it can be used easily and casually. Therefore, it is expected to contribute to the social spread of the menstrual symptom reliever.

Industrial Applicability

[0100] According to the present invention, there are provided a menstrual symptom reliever with an improved menstrual symptom relief effect, a stick-shaped menstrual symptom reliever including the menstrual symptom reliever, and a menstrual symptom relief method using the menstrual symptom reliever.

Explanation of Signs

[0101] 1 Microwave distillation apparatus 2 Distillation tank 3 Microwave heating apparatus 4 Stirring paddle 5 Airflow inlet pipe 6 Distillate outflow pipe 7 Cooling apparatus 8 Heating control apparatus 9 Vacuum pump 10 Pressure regulating valve 11 Pressure control apparatus 12 Object to be distilled 13 Distillate 21 Stick-shaped menstrual symptom reliever 22 Oily solid agent 23 Case

Claims

1. A menstrual symptom relieving agent comprising, as an active ingredient, a squeezed liquid, extract or distillate of at least one of the wood of a tree and the leaves of a tree.

2. The method of claim 1 , wherein the pressed liquid, the extract or the distillate is an oily component.

3. 2. The menstrual symptom relieving agent according to claim 1, wherein the tree comprises at least one tree selected from the group consisting of the genus Chamaecyparis of the Cupressaceae family, the genus Cedrus of the Cupressaceae family, the genus Abies of the Pinaceae family, the genus Eucalyptus of the Myrtaceae family, the genus Sciadopitys of the Cupressaceae family, and the genus Thuja of the Cupressaceae family.

4. The menstrual symptom relief agent of claim 3, wherein the tree comprises a tree of the genus Abies of the family Pinaceae.

5. The menstrual symptom relief agent according to claim 1, which is used for premenstrual symptoms.

6. The menstrual symptom relief agent according to claim 1, which is used for symptoms during menstruation.

7. 2. The menstrual symptom relieving agent according to claim 1, which is used for the purpose of relieving at least one of physical symptoms and mental symptoms.

8. 8. The menstrual symptom relieving agent according to claim 7, wherein the physical symptoms include at least one symptom selected from the group consisting of appetite disorder, sleep disorder, breast pain, breast swelling, bloating, weight gain, headache, joint pain and muscle pain.

9. The method for relieving menstrual symptoms according to claim 7, wherein the mental symptoms include at least one symptom selected from the group consisting of depression, anxiety, emotional instability, anger, lethargy, decreased concentration, and a feeling of being overwhelmed.

10. Case and an oily solid agent contained in the case; Equipped with A stick-shaped menstrual symptom relief agent, comprising the oily solid preparation comprising the menstrual symptom relief agent according to any one of claims 1 to 9.

11. A container; A fragrance contained in the container; Equipped with A fragrance-type menstrual symptom relief agent, comprising the menstrual symptom relief agent according to any one of claims 1 to 9.

12. A container; A bath additive contained in the container; Equipped with A bath additive-type menstrual symptom reliever comprising the menstrual symptom reliever according to any one of claims 1 to 9.

13. 1. A method for relieving menstrual symptoms, comprising: A method for relieving menstrual symptoms, comprising volatilizing the agent for relieving menstrual symptoms according to any one of claims 1 to 9.

14. 1. A method for relieving menstrual symptoms, comprising: A method for relieving menstrual symptoms, comprising inhaling the agent for relieving menstrual symptoms according to any one of claims 1 to 9.

15. 1. A method for relieving menstrual symptoms, comprising: A method for relieving menstrual symptoms, comprising continuously using the agent for relieving menstrual symptoms according to any one of claims 1 to 9 from 10 days before the onset of menstruation until during menstruation.

16. 1. A method for relieving menstrual symptoms, comprising: A method for relieving menstrual symptoms, comprising continuously using the agent for relieving menstrual symptoms according to any one of claims 1 to 9 from 5 days before the onset of menstruation until during menstruation.

17. 1. A method for relieving menstrual symptoms, comprising: A method for relieving menstrual symptoms, comprising using the menstrual symptom relieving agent according to any one of claims 1 to 9 when symptoms occur during menstruation.

18. A step 1 in which a subject obtains an evaluation (1) regarding menstrual symptoms before menstruation without smelling the menstrual symptom relieving agent according to any one of claims 1 to 9; A step 2 in which a subject obtains an evaluation (2) regarding menstrual symptoms after menstruation without smelling the menstrual symptom relieving agent according to any one of claims 1 to 9; A step 3 in which a subject sniffs the menstrual symptom relief agent according to any one of claims 1 to 9 before menstruation and obtains an evaluation regarding menstrual symptoms (3); a step 4 of determining whether or not premenstrual syndrome has developed by comparing the evaluation (1) obtained in the step 1 with the evaluation (2) obtained in the step 2; A step 5 of comparing the evaluation (1) and the evaluation (3) obtained from the subject who was found to have developed premenstrual syndrome in the step 4; A method for evaluating the effect of alleviating menstrual symptoms.

19. The evaluation method according to claim 18 , wherein in each of the steps 1, 2, 3, 4, and 5, an evaluation is obtained before the onset of menstruation or on at least one day counting from the onset of menstruation.

20. a first output unit that outputs a question about menstrual symptoms at least once from a certain period after the previous menstruation until the next menstruation; a first acquisition unit that acquires a premenstrual answer to the question without smelling the menstrual symptom reliever according to any one of claims 1 to 9; a second output unit that outputs a question about menstrual symptoms at least once during a certain period of time after the start of menstruation; a second acquisition unit that acquires an answer to the question after the end of menstruation without smelling the menstrual symptom reliever according to any one of claims 1 to 9; a third output unit that outputs a question about menstrual symptoms at least once from a certain period after the last menstruation until the next menstruation; A third acquisition unit that acquires a response to the question before menstruation by sniffing the menstrual symptom alleviating agent according to any one of claims 1 to 9; a first determination unit that determines whether or not a premenstrual syndrome occurs by comparing a response from the first acquisition unit with a response from the second acquisition unit; a second determination unit that determines whether the menstrual symptom has been improved by the menstrual symptom-relieving agent by comparing the responses of the first and third acquisition units obtained from the subject who has been confirmed to have premenstrual syndrome by the first determination unit; an output unit that outputs a result determined by the second determination unit; A system for determining improvement of menstrual symptoms.

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