Foamable external preparation for skin

Abstract

To provide an external preparation for skin that incorporates an active ingredient capable of improving the condition of skin, offering excellent usability, and further enhancing the effects of carbon dioxide gas and the like.SOLUTION: Provided is a kit for obtaining a foamable external preparation for skin, where a first agent is a composition containing a carbon dioxide gas-releasing substance and water, a second agent is a composition containing an acid, at least one of the first agent and the second agent contains niacinamide, and at least one of the first agent and the second agent contains a thickener. Also provided is a foamable external preparation for skin containing niacinamide, a carbon dioxide gas-releasing substance, an acid, a thickener, and water.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a kit for obtaining a foaming topical skin preparation containing niacinamide, and a foaming topical skin preparation containing niacinamide.

Background Art

[0002] Conventionally, topical skin preparations containing extracts having a blood circulation promoting effect on the skin have been used. Since these extracts have insufficient effects when formulated in small amounts and cause excessive irritation to the skin when formulated in large amounts, proposals have been made for topical skin preparations that contain carbon dioxide gas to enhance the blood circulation promoting effect. Many of these generate carbon dioxide gas by the reaction of an acidic substance and a carbon dioxide generating substance. As the dosage form of these topical skin preparations, those in which the acidic substance and the carbon dioxide generating substance are separate agents and are mixed and foamed at the time of use are known from the viewpoint of maintaining the carbon dioxide generating ability of the topical skin preparation for a long period (Patent Documents 1 and 2).

[0003] On the other hand, for the purpose of enjoying the effects on the skin, various active ingredients have been studied for formulation in cosmetics. For example, since niacinamide has effects as whitening, anti-wrinkle, and anti-aging, various topical skin preparations containing niacinamide have been proposed (Patent Document 3). However, the combined use of niacinamide and carbon dioxide gas has not been verified.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0005] Therefore, the inventors added new components to the foaming topical skin preparation, and conducted various studies on active ingredients that can improve the skin condition, have excellent usability, and further enhance the effects of carbon dioxide gas, etc. As a result, they found that blending niacinamide into the foaming topical skin preparation solves the above problems, and thus completed the present invention.

Means for Solving the Problems

[0006] That is, the present invention is as follows. <1>A kit for obtaining a foaming topical skin preparation, wherein the first agent is a composition containing a carbon dioxide gas generating substance and water, the second agent is a composition containing an acid, at least one of the first agent and the second agent contains niacinamide, and at least one of the first agent and the second agent is a composition containing a thickening agent. <2>The kit according to <1>, wherein both the first agent and the second agent contain niacinamide. <3>The kit according to <2>, wherein the content of niacinamide in the first agent and the second agent is 1.5% by mass or more. <4>The kit according to <1>, wherein at least one of the first agent and the second agent contains a polyhydric alcohol. <5>A foaming topical skin preparation characterized by containing niacinamide, a carbon dioxide gas generating substance, an acid, a thickening agent, and water. <6>The foaming topical skin preparation according to <5>, further containing a polyhydric alcohol and water.

Effects of the Invention

[0007] According to the present invention, by containing niacinamide together with a carbon dioxide-generating substance, an acid, a thickener, and water, a foaming topical skin preparation excellent in usability can be obtained. Further, according to the present invention, since the dissolved carbon dioxide concentration in the topical skin preparation increases, the effect of niacinamide can be enhanced by carbon dioxide, and a foaming topical skin preparation excellent in effects on the skin such as a moisturizing effect and a whitening effect can be obtained. Further, according to the present invention, by using the kit of the present invention, it is easy to mix at the time of use, so that a foaming topical skin preparation that can be easily used can be obtained.

Mode for Carrying Out the Invention

[0008] Hereinafter, the foaming topical skin preparation of the present invention will be described in detail. Note that the present invention is not limited to the embodiments shown below, and can be changed within the scope that those skilled in the art can conceive, such as other embodiments, additions, modifications, deletions, etc., and as long as the actions and effects of the present invention are exhibited in any aspect, it is included in the scope of the present invention.

[0009] <Niacinamide> The foaming topical skin preparation of the present invention is characterized by containing niacinamide. Niacinamide is an amide of niacin (nicotinic acid / vitamin B3) and is a kind of vitamin B group and a water-soluble vitamin. In the present invention, as niacinamide, those usually used in cosmetics, quasi-drugs, etc. can be used, and for example, those extracted from natural products, those purified therefrom, those synthesized by known methods, etc., and commercially available products can also be used.

[0010] When the foaming topical skin preparation of the present invention is a two-component kit, niacinamide may be contained in at least one of the first component and the second component, and it is preferably contained in both the first component and the second component. The content of niacinamide incorporated into the first component of the kit for the foaming topical skin preparation is not particularly limited, but it is preferably 1.5% by mass or more, more preferably 3% by mass or more, and particularly preferably 5% by mass or more from the viewpoint of obtaining a topical preparation with a good carbon dioxide generation amount and good usability in the foaming topical skin preparation. Also, the upper limit is not particularly limited, but it is preferably 30% by mass or less, more preferably 20% by mass or less, and particularly preferably 10% by mass or less from the viewpoint of obtaining a foaming topical skin preparation with excellent usability and enjoying the effects of niacinamide. The content of niacinamide incorporated into the second component of the kit for the foaming topical skin preparation is not particularly limited, but it is preferably 1.5% by mass or more, more preferably 3% by mass or more, and particularly preferably 5% by mass or more from the viewpoint of obtaining a topical preparation with a good carbon dioxide generation amount and good usability in the foaming topical skin preparation. Also, the upper limit is not particularly limited, but it is preferably 30% by mass or less, more preferably 20% by mass or less, and particularly preferably 10% by mass or less from the viewpoint of obtaining a foaming topical skin preparation with excellent usability and enjoying the effects of niacinamide. The content of niacinamide in the foaming topical skin preparation of the present invention can be analyzed, for example, by high performance liquid chromatography.

[0011] Also, in the foaming topical skin preparation of the present invention, the content of niacinamide is not particularly limited, but it is preferably 1.5% by mass or more, more preferably 3% by mass or more, and particularly preferably 5% by mass or more from the viewpoint of obtaining a topical preparation with a good carbon dioxide generation amount and good usability in the foaming topical skin preparation. Also, the upper limit is not particularly limited, but it is preferably 30% by mass or less, more preferably 20% by mass or less, and particularly preferably 10% by mass or less from the viewpoint of obtaining a foaming topical skin preparation with excellent usability and enjoying the effects of niacinamide.

[0012] <Carbon dioxide generating substance> The foaming topical skin preparation of the present invention is characterized by containing a carbon dioxide gas generating substance. As the carbon dioxide gas generating substance used in the present invention, various substances can be used without particular limitation. Further, the carbon dioxide gas generating substance to be used is preferably solid, and more preferably granular, fine granular, or powdery from the viewpoint of solubility in water or a humectant.

[0013] Examples of the carbon dioxide gas generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, and sodium sesquicarbonate, and hydrogen carbonates such as ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate, and calcium hydrogen carbonate. One or more of these are used. Among these, hydrogen carbonates can be preferably used, and sodium hydrogen carbonate is more preferable in that it can achieve an appropriate foaming power when reacting with an acid.

[0014] When a carbon dioxide gas generating substance is blended in a kit for obtaining the foaming topical skin preparation of the present invention, it may be blended in at least one of the first agent and the second agent, but it is preferably blended in the first agent from the viewpoint of the stability of the composition.

[0015] When the foaming topical skin preparation of the present invention is a two-agent type kit and a carbon dioxide gas generating substance is blended in the first agent, the content of the carbon dioxide gas generating substance in the composition of the first agent is preferably 0.05 to 40% by mass, more preferably 0.1 to 35% by mass, and particularly preferably 0.5 to 30% by mass.

[0016] Further, the content of the carbon dioxide gas generating substance in the foaming topical skin preparation of the present invention is preferably 0.01 to 25% by mass, more preferably 0.05 to 20% by mass, and particularly preferably 0.1 to 15% by mass in the foaming topical skin preparation. Note that the content of the carbon dioxide gas generating substance is the total amount when two or more types of carbon dioxide gas generating substances are blended.

[0017] <acid> The foaming topical skin preparation of the present invention is characterized by containing an acid. The acid used in the present invention may be either an organic acid or an inorganic acid, and one or more of these may be used.

[0018] Examples of the organic acid include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid or their salts, dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, and terephthalic acid or their salts, acidic amino acids such as glutamic acid and aspartic acid or their salts, oxyacids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, and gluconic acid or their salts, etc. Examples of the inorganic acid include inorganic acids such as phosphoric acid and sulfurous acid or their salts, and one or more of these can be used. Among them, from the viewpoints of safety and solubility in the second agent, citric acid or its salts, ascorbic acid or its salts, malic acid or its salts, and succinic acid or its salts are preferable, and citric acid or its salts and ascorbic acid or its salts are more preferable.

[0019] When an acid is formulated in the kit for obtaining the foaming topical skin preparation of the present invention, it may be formulated in at least one of the first agent and the second agent, but from the viewpoint of the stability of the composition, it is preferably formulated in the second agent. Also, it is preferable that the second agent is not an agent in which water and the thickening agent are the same.

[0020] When the foaming topical skin preparation of the present invention is a two-agent kit and an acid is formulated in the second agent, the content of the acid in the composition of the second agent is preferably 0.05 to 99% by mass, more preferably 0.1 to 98% by mass, and particularly preferably 0.5 to 30% by mass.

[0021] Moreover, the content of the acid in the foaming topical skin preparation of the present invention is preferably 0.01 to 20% by mass, more preferably 0.05 to 15% by mass, and particularly preferably 0.1 to 10% by mass in the foaming topical skin preparation. Note that the content of the acid is the total amount when two or more kinds of acids are formulated.

[0022] <Thickener> The foaming topical skin preparation of the present invention is characterized by containing a thickener. The thickener that can be used in the foaming topical skin preparation of the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, topical pharmaceuticals, quasi-drugs, etc., and synthetic polymers, semi-synthetic polymers, natural polymers, viscous minerals, etc. can be used. The thickener can be used in either the first agent or the second agent, but it is preferably used in the first agent.

[0023] Examples of the synthetic polymer include hydrophilic synthetic polymers such as carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymer, acrylates / acrylic acid alkyl crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer.

[0024] Examples of the semi-synthetic polymer include cellulose derivatives (such as carboxymethyl cellulose or its salts, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sulfonated cellulose derivatives, etc.), propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, etc.

[0025] Examples of natural polymers include polysaccharides and their derivatives, such as tamarind gum, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, agar, agarose, mannan, curdlan, alginic acid or its salts, gum arabic, pectin, quince seed, starch, algocolloid, chondroitin sulfate or its salts, chitosan and its derivatives. Other natural polymers include nucleic acids or their salts, ribonucleic acids or their salts, casein, collagen, gelatin, albumin, fibroin, elastin, keratin, water-soluble proteins such as sericin, hyaluronic acid or its salts, mucopolysaccharides such as chondroitin sulfate, and the like.

[0026] Examples of clay minerals include laponite, bentonite, smectite kaolinite, montmorillonite, and the like.

[0027] Among the above thickeners, it is preferable to use those with high solubility or dispersibility because they can be uniformly dissolved or dispersed without forming lumps of the thickener, and can alleviate the rough feeling of the skin caused by undissolved or undispersed components.

[0028] Examples of such thickeners include carboxyvinyl polymer, polyvinyl alcohol, sodium polyacrylate, acrylic acid - methacrylic acid alkyl copolymer, tamarind gum, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, cellulose derivatives, galactan, gum arabic, tragacanth gum, agar, mannan, curdlan, alginic acid or its salts, collagen, gelatin, albumin, etc. It is preferable to use tamarind gum, alginic acid or its salts, carboxymethyl cellulose or its salts, hydroxyethyl cellulose. One or more of the above thickeners can be used.

[0029] In the foaming topical skin preparation of the present invention, the thickener can be formulated into either the first agent or the second agent, and it is preferably formulated into the same agent as water.

[0030] The foaming topical skin preparation of the present invention is a two-component kit. When a thickening agent is formulated in the first component, the content of the thickening agent in the composition of the first component is preferably 0.01 to 30% by mass, more preferably 0.1 to 25% by mass, and particularly preferably 0.5 to 20% by mass. When a thickening agent is formulated in the second component, the content of the thickening agent in the composition of the second component is preferably 0.01 to 30% by mass, more preferably 0.1 to 25% by mass, and particularly preferably 0.5 to 20% by mass.

[0031] In addition, the content of the thickening agent in the foaming topical skin preparation of the present invention is preferably 0.01 to 20% by mass, more preferably 0.05 to 15% by mass, and particularly preferably 0.1 to 10% by mass in the foaming topical skin preparation. Note that when two or more kinds of thickening agents are blended, the content is the total amount thereof.

[0032] <Water> The foaming topical skin preparation of the present invention is characterized by containing water. As the water used in the present invention, water that can be used in cosmetics, topical pharmaceuticals, quasi-drugs, etc. can be used, and purified water, distilled water, membrane-filtered water, ion-exchanged water are preferred. In the present invention, the content of water is not particularly limited and can be blended in either the first component or the second component. The amount of water in the first component is preferably 1% by mass or more, more preferably 5% by mass or more, and particularly preferably 10% by mass or more in the composition of the first component. When water is blended in the second component, it is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and particularly preferably 1% by mass or more in the composition of the second component. Also, it is preferably 0.1% by mass or more, more preferably 1 to 85% by mass, and particularly preferably 10 to 80% by mass in the foaming topical skin preparation. Further, in the present invention, water is preferably contained in the same component as the thickening agent.

[0033] <Polyhydric alcohol> The foaming topical skin preparation of the present invention preferably contains a polyhydric alcohol. The polyhydric alcohol used in the present invention has two or more hydroxy groups in one molecule and is not particularly limited as long as it can be usually used in cosmetics, topical pharmaceuticals, quasi-drugs, etc. For example, polyglycerols such as glycerin, diglycerin, triglycerin, and tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanediol, sugar alcohols such as erythritol, maltitol, mannitol, sorbitol, and xylitol, polyglycerol derivatives, sugars such as sucrose and trehalose, etc. are mentioned. From the viewpoints of storage stability, production cost, and alleviation of skin irritation during use, it is preferable to use at least one of glycerin, diglycerin, 1,3-butylene glycol, 1,4-butylene glycol, dipropylene glycol, and polyethylene glycol. One or more polyhydric alcohols can be used.

[0034] In the present invention, when a polyhydric alcohol is formulated, its content is not particularly limited and can be formulated into either the first agent or the second agent, and it is preferable to formulate it into both the first agent and the second agent. The polyhydric alcohol is preferably 1% by mass or more, more preferably 3% by mass or more, and particularly preferably 5 to 50% by mass in the composition of the first agent. Also, in the composition of the second agent, 1% by mass or more is preferable, 3% by mass is more preferable, and 5 to 95% by mass is particularly preferable. Furthermore, the content of the polyhydric alcohol in the foaming topical skin preparation may be 5% by mass or more, preferably 10 to 90% by mass, more preferably 20 to 80% by mass or more, and particularly preferably 30 to 70% by mass. When two or more polyhydric alcohols are formulated, it is the total amount thereof.

[0035] <Other components> In the foaming topical skin preparation of the present invention, other components can be blended as necessary in addition to the above components. Examples of other components include active ingredients other than niacinamide such as vitamins, humectants other than polyhydric alcohols, dispersants, plasticizers, preservatives, fragrances, anionic surfactants, amphoteric surfactants, nonionic surfactants, cationic surfactants and other surfactants, deodorants, chelating agents, antioxidants, antibacterial agents, fungicides and mildewproofing agents, anti-inflammatory agents, whitening agents, and one or more of the components usually used in topical skin preparations such as beauty components and medicinal components like animal extracts and plant extracts.

[0036] When blending an active ingredient into the topical skin preparation of the present invention, the ingredient is not particularly limited and can be used according to the purpose, such as drugs and plants used in cosmetics, topical pharmaceuticals, quasi-drugs, etc. Representative examples include, for example, anti-inflammatory agents such as glycyrrhizic acid and its derivatives and their salts, glycyrrhetinic acid and its derivatives and their salts, allantoin, guaiazulene; whitening agents such as ascorbic acid and its derivatives and their salts, cysteine and its derivatives and its salts, glabridin, glabrene, liquiritin, isoliquiritin, placenta, hydroquinone and its derivatives, resorcinol and its derivatives, glutathione; anti-seborrheic agents such as sulfur, tiopronin; bactericides such as salicylic acid, peony extract; plant components such as tocopherol and its derivatives, licorice, aloe, tea leaves; hormones such as estradiol. When using plant components, the whole plant, leaves (leaf blade, petiole, etc.), fruits (ripe, unripe, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tuberous roots, etc. can be used as they are, after being cut, crushed, pulverized, squeezed, extracted, or the processed ones can be dried or powdered. The active ingredient used in the present invention can be used in either the first agent or the second agent.

[0037] When using an extract in the present invention, examples of the solvent used for extraction include organic solvents such as water, methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, hexylene glycol, glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, and acetone. These can be used alone or in combination of two or more. From the viewpoint of safety and the like, it is preferable to use water, ethanol, 1,3-butylene glycol, which are harmless to the human body, or a mixed solvent thereof as the extraction solvent. The extraction may be carried out at a temperature below the boiling point of the extraction solvent, and the extraction time can be appropriately changed depending on the extraction temperature.

[0038] When a surfactant is added to the foaming skin external preparation of the present invention, usable surfactants include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.Surfactants can be synthetic or natural surfactants, but natural surfactants are preferred from the viewpoint of safety to skin.The term "natural surfactant" as used herein refers to a substance that has a surfactant effect that is mainly derived from animals or plants, and specific examples include phospholipids such as lecithin, glycolipids, lanolin, cholesterol, saponin, sphingolipids such as ceramide, pectin, glycyrrhizinate, bile acid, and plant-extracted amino acid surfactants.Among them, it is preferable to contain an extract containing phospholipids, saponin, sphingolipids, pectin, and glycyrrhizinate, and it is particularly preferable to contain an extract containing saponin.As the extract containing saponin, it is preferable to use an extract derived from plants. Examples of plants containing saponin include soybeans, adzuki beans, kidney beans, spinach, sugar beets, grapes, bellflowers, licorice, Senega, Quillaja, Sapindus mukorossi, soapwort, ginseng, loofah, tea seeds, Sophora japonica, plants of the lily family, plants of the Dioscorea family, Anemone arbutifolia, and Bakumondou. In the present invention, the extract containing saponin is preferably an extract of one or more plants selected from soybeans, adzuki beans, licorice, Sapindus mukorossi, and loofah, and is particularly preferably an extract of Sapindus mukorossi.

[0039] <foaming skin topical agent> The foaming topical skin preparation of the present invention is characterized by containing niacinamide, a carbon dioxide generating substance, an acid, a thickening agent, and water. The foaming topical skin preparation of the present invention also includes a composition obtained by mixing multi-agent kits. For example, when the foaming topical skin preparation of the present invention is a two-agent kit, the first agent and the second agent can be mixed and used. Specifically, after mixing the first agent and the second agent, it can be applied to the skin and left standing for a certain period of time before use. Further, the foaming topical skin preparation of the present invention can also be obtained by mixing an agent containing niacinamide, a carbon dioxide generating substance, an acid, and a thickening agent with water. Since the amount of carbon dioxide generated by the foaming topical skin preparation of the present invention is improved, the effects of carbon dioxide can be highly enjoyed, and it is excellent for use as a pack preparation.

[0040] <Kit for obtaining a foaming topical skin preparation> The kit for obtaining the foaming topical skin preparation of the present invention is characterized in that the first agent is a composition containing a carbon dioxide generating substance and water, the second agent is a composition containing an acid, at least one of the first agent and the second agent contains niacinamide, and at least one of the first agent and the second agent contains a thickening agent. Since the first agent of the kit of the present invention contains a carbon dioxide generating substance and the second agent contains an acid, a foaming topical skin preparation that generates carbon dioxide can be obtained by mixing the first agent and the second agent.

[0041] The kit for obtaining the foaming topical skin preparation of the present invention preferably has the following configuration. (A) A kit in which the first agent is a composition containing a carbon dioxide generating substance, a thickening agent, and water, the second agent is a composition containing an acid, and at least one of the first agent and the second agent contains niacinamide. (B) A kit in which the first agent is a composition containing a carbon dioxide generating substance and water, the second agent is a composition containing an acid and a thickening agent, and at least one of the first agent and the second agent contains niacinamide.

[0042] Kit of (A) The kit of (A) in the present invention is characterized in that the first agent is a composition containing a carbon dioxide generating substance, a thickener and water, the second agent is a composition containing an acid, and at least one of the first agent and the second agent is a composition containing niacinamide. It is preferable that the kit of (A) contains niacinamide in both the first agent and the second agent.

[0043] Also, in the kit of (A), it is preferable that at least one of the first agent and the second agent contains a polyhydric alcohol, and it is more preferable that both the first agent and the second agent contain a polyhydric alcohol. Furthermore, the second agent may contain a thickener and / or water.

[0044] The composition of the first agent constituting the kit of (A) of the present invention is preferably a viscous composition with a high viscosity. Specifically, the viscosity at 25°C is preferably 1,000 mPa·s or more, more preferably 3,000 mPa·s or more, and particularly preferably 5,000 mPa·s or more. Also, from the perspective of handling, particularly from the perspectives of ease of mixing and ease of coating after mixing, 100,000 mPa·s or less is preferable, 70,000 mPa·s is more preferable, and 50,000 or less is particularly preferable.

[0045] When the composition of the second agent constituting the kit of (A) of the present invention contains water, the viscosity of the second agent is preferably low. Specifically, the viscosity at 25°C is preferably 50,000 mPa·s or less, more preferably 30,000 mPa·s or less, and particularly preferably 10,000 mPa·s or less. The viscosity of the foaming topical skin preparation (including the first agent and the second agent) of the present invention can be measured, for example, with a B-type viscometer (Brookfield rotational viscometer, temperature: 25°C, rotation speed: 4 - 20 rpm).

[0046] Kit of (B) In the kit of (B) of the present invention, the first agent is a composition containing a carbon dioxide generating substance and water, the second agent is a composition containing an acid and a thickener, and at least one of the first agent and the second agent contains niacinamide. It is characterized in that. In the kit of (B), it is preferable that both the first agent and the second agent contain niacinamide.

[0047] Further, in the kit of (B), it is preferable that at least one of the first agent and the second agent contains a polyhydric alcohol, and it is more preferable that both the first agent and the second agent contain a polyhydric alcohol. Furthermore, the second agent may contain water.

[0048] Method of using the kit When the kit of the present invention is used to obtain a foaming topical skin preparation, the first agent and the second agent are mixed in an appropriate container. The first agent and the second agent are preferably mixed at a ratio of 0.1:1 to 50:1, and more preferably at a ratio of 0.5:1 to 40:1.

[0049] As a method for storing the composition constituting the kit of the present invention, a method for storing cosmetics, topical pharmaceuticals, quasi-drugs, etc. can be used, and there is no particular limitation. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples include cup-shaped, tube-shaped, bag-shaped, bottle-shaped, stick-shaped, pump-shaped, jar-shaped, canned, etc. In addition, the material constituting the storage container can be selected and used, for example, from plastics, glass, aluminum, paper, various polymers, etc. alone or in combination of two or more, but is not limited thereto.

[0050] Specific examples of the container include storage containers such as aluminum sticks and aluminum bags laminated with polyethylene terephthalate on the inner surface, stand-up pouches with zippers, and polyethylene terephthalate storage containers with lids heat-sealed with aluminum films laminated with polyethylene terephthalate on the inner surface, etc., in terms of airtightness, storage stability of the contents, manufacturing cost, etc.

[0051] <Use of the foaming topical skin preparation> The foaming topical skin preparation of the present invention is not only a cosmetic aimed at whitening, improving skin texture, improving freckles, rejuvenating the skin, firming the skin, partial slimming, cleansing the skin, smoothing the skin, refining skin texture, keeping the skin healthy, preventing rough skin, tightening the skin, moisturizing the skin, replenishing and maintaining skin moisture and oil, maintaining skin flexibility, protecting the skin, preventing skin dryness, softening the skin, giving firmness to the skin, giving gloss to the skin, smoothing the skin, preventing sunburn-induced spots and freckles, and making fine wrinkles caused by dryness less noticeable, but also for the prevention of skin blemishes, skin roughness, sweating, sunburn, cracks, red streaks, acne, oily skin, razor burn, sunburn-induced spots and freckles, preventing flushing after sunburn or snowburn, tightening the skin, cleansing the skin, smoothing the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing skin dryness, etc. It can be suitably used for any of pharmaceuticals such as cosmetics, quasi-drugs, and drugs. The foaming topical skin preparation of the present invention is preferably used as a cosmetic or a quasi-drug, and more preferably used as a cosmetic such as a lotion, cream, pack agent, peeling agent, or medicinal cosmetic. Among them, in particular, when used as a pack agent, it is preferable because it has a good feeling of use and it is easy to obtain a high skin condition improving effect in a short time.

[0052] When the foaming topical skin preparation obtained by using the kit of the present invention is used as a pack agent, it may be applied to a thickness of 0.2 mm or more, preferably 0.5 mm or more so as to cover the desired site. By applying to a thickness of 0.1 mm or more, an effect of improving skin condition can be obtained. Also, the use time may be 1 minute or more, preferably 3 minutes or more, more preferably 5 minutes or more. After the application is completed, if the composition has gelled, it can be peeled off from the skin, wiped off after peeling the gel if necessary, or washed away with water, etc., removed by wiping off after removing the pack agent with hands or a spatula, or washed away with water, etc.

[0053] The foaming topical skin preparation of the present invention can be produced according to a conventional method. That is, at a predetermined temperature of about 25°C, by stirring each component, the first agent and the second agent constituting the kit for the foaming topical skin preparation of the present invention can be obtained. In addition, appropriate heating may be performed for the purpose of enhancing the solubility of the components to be constituted.

Examples

[0054] Hereinafter, the present invention will be described based on examples, but the scope of the present invention is not limited to these examples. In the following examples and reference examples, commercially available products were used unless otherwise specified for the raw materials used. Further, the blending amounts of the respective components are in mass% unless otherwise specified.

[0055] [Production of Foaming Topical Skin Preparation] Examples 1 to 5, Comparative Examples 1 to 4 According to the composition shown in Table 1, the kit of the present invention was produced.

[0056] [First Agent] Purified water was added to a beaker, and then the raw materials described in the first agent were added. The mixture was stirred at 60°C until it became uniform and then cooled to obtain the first agent. [Second Agent] All the raw materials described in the second agent were added to a beaker, stirred and dissolved at 50°C until it became uniform, and then cooled to obtain the second agent.

[0057]

Table 1

[0058] [Evaluation of Foaming Topical Skin Preparation] According to the following procedures, the characteristics of the foaming topical skin preparations obtained in Examples 1 to 5 and Comparative Examples 1 to 4 were evaluated.

[0059] [Evaluation Example 1. Evaluation of Dissolved Carbon Dioxide Concentration in Composition] 20 g of the first agent and 10 g of the second agent were mixed in a 100 mL beaker for 10 seconds. After mixing, the dissolved carbon dioxide concentration in the composition was measured using a CGP-31 carbon dioxide concentration meter (manufactured by Toa DKK Corporation) 10 minutes later. The results are shown in Table 2.

[0060] <Evaluation Example 2. Evaluation of Use Feeling> Using the kits of the present invention obtained in Examples 1 to 5 and Comparative Examples 1 to 4, pack agents were prepared, and evaluations of each item were conducted regarding the time of use and after use of the obtained pack agents. First, the inner forearm measurement site (5 × 5 cm) of the subjects (1 male and 1 female in their 20s) was washed with a facial cleanser and allowed to rest quietly for 15 minutes. Next, 2 g of the pack agent in which the first agent: the second agent was mixed at a ratio of 2:1 was applied to the measurement site and allowed to stand for 10 minutes. Next, the solidified (gelled) pack agent was removed and wiped off with a cloth lightly moistened with water. Thereafter, a questionnaire was conducted regarding the ease of application after mixing, the uniformity after application, the whiteness of the skin color after removing the pack agent, and the absence of wrinkles. The evaluation of the questionnaire was carried out on a 5-point scale of 1 (very bad) to 3 (usable as a product) to 5 (very good) for the items in Table 1, and the average score was calculated. In addition, the subjects stayed quietly in the measurement room during the measurement. The results are shown in Table 2.

[0061] [Ease of Application of Pack Agent] 5: Easy to spread, high adhesion to the skin, does not drip even when moving 4: Easy to apply, not likely to drip even when moving slightly 3: Can be applied, does not drip if not moved 2: Slightly difficult to apply, drips 1: Difficult to apply, drips [Uniformity of Pack Agent] 5: Very easy to mix, high uniformity of the pack agent 4: Easy to mix, slightly high uniformity of the pack agent 3: Easy to mix, can apply the pack agent uniformly (more difficult to apply uniformly than 5 and 4) 2: Slightly difficult to mix, the pack agent is non-uniform 1: Difficult to mix, the pack agent is non-uniform [Whiteness of Skin] 5: The skin color became clearly brighter. 4: The skin color became slightly brighter. 3: It seems that the skin color became a little brighter. 2: Little change was felt (it became slightly brighter). 1: No change was felt at all. [Degree of visibility of wrinkles] 5: Fine wrinkles were clearly reduced. 4: Fine wrinkles became less noticeable. 3: It seems that fine wrinkles became less noticeable. 2: Little change was felt (there was a slight change). 1: No change was felt at all.

[0062] <Evaluation Example 3. Evaluation of stratum corneum water content> Using the kits of the present invention obtained in Examples 1 to 5 and Comparative Examples 1 to 4, a pack agent was prepared, and the stratum corneum water content after using the obtained pack agent was evaluated. First, the inner forearm measurement site (5×5 cm) of the subjects (one male and one female in their 20s) was washed with a facial cleanser and allowed to rest quietly for 15 minutes. Next, 2 g of the pack agent obtained by mixing the first agent and the second agent at a ratio of 2:1 was applied to the measurement site and allowed to stand for 10 minutes. Next, after removing the solidified (gelled) pack agent, the stratum corneum water content was measured using a skin surface stratum corneum water content measuring device SKICON-200EX (manufactured by IBS Co., Ltd.). The value represents the average value of two persons. Incidentally, the subjects rested quietly in the measurement room during the measurement. The results are shown in Table 2.

[0063] <Evaluation Example 4. Evaluation of color difference> Using the kits of the present invention obtained in Examples 1 to 5 and Comparative Examples 1 to 4, pack agents were prepared, and the color difference before and after using the obtained pack agents was evaluated. First, the inner forearm measurement site (5×5 cm) of the subjects (one male and one female in their 20s) was washed with facial cleanser and allowed to rest quietly for 15 minutes. 2 g of the pack agent obtained by mixing the first agent and the second agent at a ratio of 2:1 was applied to the measurement site and allowed to stand for 10 minutes. Next, after removing the solidified (gelled) pack agent, the L value was measured using a color difference meter CR-400 (manufactured by Konica Minolta). By subtracting the L value measured before application (before use), the change value (ΔL) of the color difference was obtained. The L value indicates the lightness (brightness) of the color. When ΔL is a positive value, it indicates that the skin color after use has become whiter than before use. The value represents the average value of the two subjects. In addition, the subjects rested quietly in the measurement room during the measurement. The results are shown in Table 2.

[0064]

Table 2

[0065] From Table 2, the foaming topical skin preparation obtained using the kit of the present invention had a higher dissolved carbon dioxide gas concentration in the composition than the foaming topical skin preparation of the comparative example. In Comparative Example 1, the carbon dioxide gas concentration in the composition could not be measured. In addition, it was easy to mix, easy to apply evenly during application, and not likely to drip, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be felt. Furthermore, the foaming topical skin preparation of the present invention had a higher stratum corneum moisture content after use and a larger change value (ΔL value) of the color difference than the foaming topical skin preparation of the comparative example, so it was excellent in moisturizing effect and whitening effect.

[0066] <Manufacture of Foaming Topical Skin Preparation> Examples 6 to 8 According to the composition shown in Table 3, the kit of the present invention was manufactured.

[0067] Example 6 [First Agent] Purified water was added to a beaker, and then the raw materials described in the first agent were added and stirred to obtain the first agent. [Second Agent] Purified water was added to a beaker, and then the raw materials described in the second agent were added and stirred to obtain the second agent. Examples 7, 8 [First Agent] Purified water was added to a beaker, and then the raw materials described in the first agent were added and stirred to obtain the first agent. [Second Agent] The raw materials described in the second agent were added to a mortar and mixed to obtain the second agent.

[0068]

Table 3

[0069] <Evaluation of the Characteristics of the Foaming Topical Skin Agent> The characteristics of the foaming topical skin agents obtained in Examples 6 to 8 were evaluated according to the following procedures. In the following evaluations, in Example 6, the first agent: the second agent = 2:1, in Example 7, the first agent: the second agent = 25:1, and in Example 8, the first agent: the second agent = 30:1 were used after mixing. <Evaluation Example 1. Evaluation of the Dissolved Carbon Dioxide Concentration> In Example 6: 20 g of the first agent and 10 g of the second agent were mixed in a 100 mL beaker. After mixing, the dissolved carbon dioxide concentration in the composition was measured using a CGP-31 carbon dioxide concentration meter (manufactured by Toa DKK Corporation). The results are shown in Table 4. In Example 7: 25 g of the first agent and 1 g of the second agent were mixed in a 100 mL beaker. After mixing, the dissolved carbon dioxide concentration in the composition was measured using a CGP-31 carbon dioxide concentration meter (manufactured by Toa DKK Corporation). The results are shown in Table 4. In Example 8: 30 g of the first agent and 1 g of the second agent were mixed in a 100 mL beaker. After mixing, the dissolved carbon dioxide concentration in the composition was measured using a CGP-31 carbon dioxide concentration meter (manufactured by Toa DKK Corporation). The results are shown in Table 4.

[0070] <Evaluation Example 2. Evaluation of the Feeling of Use> Using the kits of the present invention obtained in Examples 6 to 8 above, pack agents were prepared, and evaluations were conducted for each item during and after use of the obtained pack agents. First, the inner forearm measurement site (5×5 cm) of the subjects (one male and one female in their 20s) was washed with a facial cleanser and allowed to rest quietly for 15 minutes. Next, 2 g of the pack agent in which the first agent and the second agent were mixed in a predetermined amount was applied to the measurement site and allowed to stand for 10 minutes. Next, the pack agent was removed, washed away with water, and the moisture was wiped off with a towel. Thereafter, a questionnaire was conducted regarding the ease of spreading after mixing, the uniformity after application, the whiteness of the skin color after removing the pack agent, and the absence of wrinkles. The evaluation of the questionnaire was performed on a 5-point scale of 1 (very bad) to 3 (usable as a product) to 5 (very good) for the items in Table 1, and the average score was calculated. In addition, the subjects remained quiet in the measurement room during the measurement. The results are shown in Table 4.

[0071] [Ease of spreading of the pack agent] 5: Easy to spread, high adhesion to the skin, does not drip even when moving 4: Easy to spread, not likely to drip even when moving slightly 3: Can be applied, does not drip if not moved 2: Slightly difficult to apply, drips 1: Difficult to apply, drips [Uniformity of the pack agent] 5: Very easy to mix, high uniformity of the pack agent 4: Easy to mix, slightly high uniformity of the pack agent 3: Easy to mix, can apply the pack agent uniformly (more difficult to apply uniformly than 5 and 4) 2: Slightly difficult to mix, the pack agent is non-uniform 1: Difficult to mix, the pack agent is non-uniform [Whiteness of the skin] 5: The skin color has become clearly brighter 4: The skin color has become slightly brighter 3: It seems that the skin color has become a little brighter 2: Hardly any change is felt (slightly brighter) 1: No change is felt at all [Ease of appearance of wrinkles] 5: Fine wrinkles were significantly reduced 4: Fine wrinkles became less noticeable 3: It seems that fine wrinkles became less noticeable 2: Little change was felt (slight change) 1: No change was felt at all

[0072] <Evaluation Example 3. Evaluation of stratum corneum moisture content> Using the kits of the present invention obtained in Examples 1 to 5 and Comparative Examples 1 to 4, pack agents were prepared, and the stratum corneum moisture content after using the obtained pack agents was evaluated. First, the inner forearm measurement site (5×5 cm) of the subjects (one male and one female in their 20s) was washed with facial cleanser and allowed to rest quietly for 15 minutes. Next, 2 g of the pack agent obtained by mixing a predetermined amount of the first agent and the second agent was applied to the measurement site and allowed to stand for 10 minutes. Next, the pack agent was removed, washed away with water, and the moisture was wiped off with a towel. Then, the stratum corneum moisture content was measured using a stratum corneum moisture content measuring device SKICON-200EX (manufactured by IBS Co., Ltd.). The value represents the average value of two persons. The subjects remained quiet in the measurement room during the measurement. The results are shown in Table 4.

[0073] <Evaluation Example 4. Evaluation of color difference> Using the kits of the present invention obtained in Examples 1 to 5 and Comparative Examples 1 to 4, pack agents were prepared, and the color difference before and after using the obtained pack agents was evaluated. First, the inner forearm measurement site (5×5 cm) of the subjects (one male and one female in their 20s) was washed with facial cleanser and allowed to rest quietly for 15 minutes. 2 g of the pack agent obtained by mixing a predetermined amount of the first agent and the second agent was applied to the measurement site and allowed to stand for 10 minutes. Next, the pack agent was removed, washed away with water, and the moisture was wiped off with a towel. Then, the L value was measured using a color difference meter CR-400 (manufactured by Konica Minolta). By subtracting the L value measured before application (before use), the change value (ΔL) of the color difference was obtained. The L value indicates the brightness (lightness) of the color. When ΔL is a positive value, it indicates that the skin color after use became whiter than before use. The value represents the average value of two persons. The subjects remained quiet in the measurement room during the measurement. The results are shown in Table 4.

[0074]

Table 4

[0075] From Table 4, the foaming topical skin preparation obtained using the kit of the present invention also had a high dissolved carbon dioxide concentration, similar to those in Examples 1 to 5. Further, it was easy to mix, easy to uniformly apply during application, and did not drip, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be experienced. Furthermore, the foaming topical skin preparation of the present invention had a high water content in the stratum corneum after use and a large change value (ΔL value) of color difference, so it was excellent in moisturizing effect and whitening effect.

[0076] From the above results, the topical skin preparation of the present invention contains niacinamide, carbon dioxide generating substance, acid, thickener and water, so it has excellent usability. Also, since the dissolved carbon dioxide concentration in the composition is high, it can be seen that it is excellent in effects on the skin such as moisturizing effect and whitening effect. Further, by using the kit of the present invention, it is easy to mix during use and can be uniformly applied, so it can be seen that an easily usable topical skin preparation can be obtained.

[0077] [Production Example 1] According to the composition shown in the following table, the kit of the present invention was produced. The obtained kit was mixed with the first agent: the second agent at a ratio of 2:1 to prepare a pack agent. An appropriate amount of the obtained pack agent was applied to the skin according to the application part. After standing for 10 minutes, the solidified pack agent was removed and wiped off with a cloth lightly moistened with water. The pack agent was easy to mix, easy to uniformly apply during application, and did not drip, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be experienced. Also, high moisturizing effect and whitening effect were obtained after use.

[0078]

Table 5

[0079] [Production Example 2] The kit of the present invention was manufactured according to the composition shown in the following table. The obtained kit was mixed with the first agent: the second agent at a ratio of 3:1 to prepare a pack agent. An appropriate amount of the obtained pack agent was applied to the skin according to the application part. After standing for 10 minutes, the solidified pack agent was removed and wiped off with a cloth lightly moistened with water. The pack agent was easy to mix, easy to apply evenly during application, and did not drip easily, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be felt. In addition, high moisturizing effect and whitening effect were obtained after use.

[0080]

Table 6

[0081] [Production Example 3] The kit of the present invention was manufactured according to the composition shown in the following table. The obtained kit was mixed with the first agent: the second agent at a ratio of 3:1 to prepare a pack agent. An appropriate amount of the obtained pack agent was applied to the skin according to the application part. After standing for 10 minutes, the solidified pack agent was removed and wiped off with a cloth lightly moistened with water. The pack agent was easy to mix, easy to apply evenly during application, and did not drip easily, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be felt. In addition, high moisturizing effect and whitening effect were obtained after use.

[0082]

Table 7

[0083] [Production Example 4] The kit of the present invention was manufactured according to the composition shown in the following table. The obtained kit was mixed with the first agent: the second agent at a ratio of 20:1 to prepare a pack agent. An appropriate amount of the obtained pack agent was applied to the skin according to the application part. After standing for 15 minutes, the pack agent was removed and rinsed with water, and then the moisture was wiped off with a towel. The pack agent was easy to mix, easy to apply evenly during application, and did not drip easily, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be felt. In addition, high moisturizing effect and whitening effect were obtained after use.

[0084] [Table 8]

[0085] [Production Example 5] According to the composition shown in the following table, the kit of the present invention was manufactured. The obtained kit was mixed with the first agent: the second agent at a ratio of 10:1 to prepare a pack agent. An appropriate amount of the obtained pack agent was applied to the skin according to the application part. After standing for 15 minutes, the pack agent was removed, washed away with water, and then the moisture was wiped off with a towel. The pack agent was easy to mix, easy to apply evenly during application, and not likely to drip, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be felt. In addition, high moisturizing effect and whitening effect were obtained after use.

[0086] [Table 9]

[0087] [Production Example 6] According to the composition shown in the following table, the kit of the present invention was manufactured. The obtained kit was mixed with the first agent: the second agent at a ratio of 5:1 to prepare a pack agent. An appropriate amount of the obtained pack agent was applied to the skin according to the application part. After standing for 20 minutes, the pack agent was removed, washed away with water, and then the moisture was wiped off with a towel. The pack agent was easy to mix, easy to apply evenly during application, and not likely to drip, so it had excellent usability and the effects such as whitening effect and wrinkle improvement effect after use could be felt. In addition, high moisturizing effect and whitening effect were obtained after use.

[0088] [Table 10] [Industrial Applicability]

[0089] The external preparation for skin of the present invention contains niacinamide together with a carbon dioxide generating substance, an acid, a thickener and water, whereby a foaming external preparation for skin having excellent usability can be obtained. Further, according to the present invention, since the dissolved carbon dioxide concentration in the external preparation for skin increases, the effect of niacinamide can be enhanced by carbon dioxide, and a foaming external preparation for skin having excellent effects on the skin such as a moisturizing effect and a whitening effect can be obtained. Further, according to the present invention, since it is easy to mix at the time of use by using the kit of the present invention, a foaming external preparation for skin that can be easily used can be obtained, and thus it has high industrial applicability.

Claims

1. A kit for obtaining a foamable topical skin preparation, characterized in that a first agent is a composition containing a carbon dioxide gas generating substance and water, a second agent is a composition containing an acid, at least one of the first agent and the second agent contains niacinamide, and at least one of the first agent and the second agent is a composition containing a thickener.

2. 2. The kit of claim 1, wherein both the first and second agents contain niacinamide.

3. The kit according to claim 1, wherein at least one of the first agent and the second agent contains a polyhydric alcohol.

4. A foaming skin preparation for external use, comprising niacinamide, a carbon dioxide generating substance, an acid, a thickener and water.

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