Systems and methods for activating analyte sensor electronics

Abstract

To provide systems and methods for activating analyte sensor electronics.SOLUTION: Various analyte sensor systems for controlling activation of analyte sensor electronic circuitry and monitoring an analyte in a host are provided. Various circuits for controlling activation of an analyte sensor system are also provided. Analyte sensor systems utilizing a state machine having a plurality of states for collecting a plurality of digital counts and waking a controller in response to a wake-up signal are also provided. Related methods for such analyte sensor systems are also provided. Systems for controlling activation of analyte sensor electronic circuitry utilizing a magnetic sensor are further provided. One or more display devices configured to display one or more analyte concentration values are also provided.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] Incorporation by reference to related applications Any and all priority claims identified in the application data sheet, or any amendments thereto, are incorporated herein by reference under 37 C.F.R. § 1.57. This application claims the benefit of U.S. Provisional Patent Application No. 62 / 666,554, filed on May 3, 2018 . The foregoing application is incorporated herein by reference in its entirety and made a part hereof as if fully set forth herein explicitly

[0002] This development generally relates to medical devices such as analyte sensors, and more specifically but not by way of limitation, to systems, devices, and methods for operating an analyte sensor electronics on such medical devices

Background Art

[0003] Diabetes mellitus is a disease in which the pancreas cannot produce enough insulin (type I or insulin-dependent), and / or insulin is not effective (type 2 or non-insulin-dependent). In a diabetic condition, the victim suffers from hyperglycemia, which is associated with many physiological disorders related to the deterioration of microvessels (renal failure, skin ulcers, or bleeding into the vitreous humor of the eye). Hypoglycemic reactions can be induced by inadvertent overdose of insulin, or by normal administration of insulin or glucose-lowering medications followed by abnormal exercise or insufficient food intake .

[0004] ​Conventionally, people with diabetes carry a self - monitoring blood glucose (SMBG) monitor, which may require an uncomfortable finger pricking method. Due to lack of comfort and convenience, diabetic patients usually measure their glucose levels only 2 - 4 times a day. Unfortunately, since these time intervals are very far apart, diabetic patients may be warned too late about hyperglycemia or hypoglycemia, and as a result, dangerous side effects may occur. In fact, not only is it likely that diabetic patients will not obtain SMBG values in a timely manner, but due to the limitations of conventional methods, it is not known whether their blood glucose level is rising (getting higher) or falling

[0005] (getting lower). As a result, various non - invasive, transdermal (e.g., transcutaneous ) and / or implantable electrochemical sensors have been developed. These devices generally transmit raw data or minimally processed data for subsequent analysis on a remote device that can include a display. Transmission to a wireless display device can be wireless. The remote device can then provide the user with information regarding the user's blood glucose level. Systems using such implantable sensors can reduce the risk that the user will fail to adjust the user's blood glucose level, as they can provide the user with more up - to - date information. Nevertheless, such systems still rely on the user to take

[0006] action to adjust the user's blood glucose level, for example, by administering an injection. Such systems may typically include a glucose sensor that can be embedded in a host and sensor electronics for processing and communicating glucose-related information. However, in such systems, the sensor and sensor electronics are typically designed to be connected for the first time by the user or host only after the sensor has been implanted in the user. As a result, the amount of user interaction associated with deploying an analyte sensor system can potentially be reduced by a pre-connected system. This background art is provided to introduce a brief context for the following summary of the invention and the detailed description of the invention. This background art is not intended to limit the scope of the claimed subject matter, nor is it to be construed as an implementation that solves all of the disadvantages or problems described above. This background art is provided to introduce a brief context for the following summary of the invention and the detailed description of the invention. This background art is not intended to limit the scope of the claimed subject matter, nor is it to be construed as an implementation that solves all of the disadvantages or problems described above. This background art is provided to introduce a brief context for the following summary of the invention and the detailed description of the invention. This background art is not intended to limit the scope of the claimed subject matter, nor is it to be construed as an implementation that solves all of the disadvantages or problems described above.

[0007] This background art is provided to introduce a brief context for the following summary of the invention and the detailed description of the invention. This background art is not intended to limit the scope of the claimed subject matter, nor is it to be construed as an implementation that solves all of the disadvantages or problems described above. This background art is provided to introduce a brief context for the following summary of the invention and the detailed description of the invention. This background art is not intended to limit the scope of the claimed subject matter, nor is it to be construed as an implementation that solves all of the disadvantages or problems described above. This background art is provided to introduce a brief context for the following summary of the invention and the detailed description of the invention. This background art is not intended to limit the scope of the claimed subject matter, nor is it to be construed as an implementation that solves all of the disadvantages or problems described above. This background art is provided to introduce a brief context for the following summary of the invention and the detailed description of the invention. This background art is not intended to limit the scope of the claimed subject matter, nor is it to be construed as an implementation that solves all of the disadvantages or problems described above. SUMMARY OF THE INVENTION PROBLEMS TO BE SOLVED BY THE INVENTION

[0008] In view of the above characteristics associated with some systems, there is a need for an analyte sensor system configured such that the analyte sensor and the analyte sensor electronics are electrically and mechanically coupled to each other before the analyte sensor is implanted in the user or host. The present disclosure generally relates to controlling the operation of sensor electronics for wireless communication of analyte data collected using an analyte sensor system. More specifically, the present disclosure relates to a number of methods for controlling such operation in an analyte sensor system in which the analyte sensor is connected both electrically and mechanically to the analyte sensor electronics before the analyte sensor is implanted in the host. In view of the above characteristics associated with some systems, there is a need for an analyte sensor system configured such that the analyte sensor and the analyte sensor electronics are electrically and mechanically coupled to each other before the analyte sensor is implanted in the user or host. The present disclosure generally relates to controlling the operation of sensor electronics for wireless communication of analyte data collected using an analyte sensor system. More specifically, the present disclosure relates to a number of methods for controlling such operation in an analyte sensor system in which the analyte sensor is connected both electrically and mechanically to the analyte sensor electronics before the analyte sensor is implanted in the host. In view of the above characteristics associated with some systems, there is a need for an analyte sensor system configured such that the analyte sensor and the analyte sensor electronics are electrically and mechanically coupled to each other before the analyte sensor is implanted in the user or host. The present disclosure generally relates to controlling the operation of sensor electronics for wireless communication of analyte data collected using an analyte sensor system. More specifically, the present disclosure relates to a number of methods for controlling such operation in an analyte sensor system in which the analyte sensor is connected both electrically and mechanically to the analyte sensor electronics before the analyte sensor is implanted in the host. In view of the above characteristics associated with some systems, there is a need for an analyte sensor system configured such that the analyte sensor and the analyte sensor electronics are electrically and mechanically coupled to each other before the analyte sensor is implanted in the user or host. The present disclosure generally relates to controlling the operation of sensor electronics for wireless communication of analyte data collected using an analyte sensor system. More specifically, the present disclosure relates to a number of methods for controlling such operation in an analyte sensor system in which the analyte sensor is connected both electrically and mechanically to the analyte sensor electronics before the analyte sensor is implanted in the host. In view of the above characteristics associated with some systems, there is a need for an analyte sensor system configured such that the analyte sensor and the analyte sensor electronics are electrically and mechanically coupled to each other before the analyte sensor is implanted in the user or host. The present disclosure generally relates to controlling the operation of sensor electronics for wireless communication of analyte data collected using an analyte sensor system. More specifically, the present disclosure relates to a number of methods for controlling such operation in an analyte sensor system in which the analyte sensor is connected both electrically and mechanically to the analyte sensor electronics before the analyte sensor is implanted in the host. In view of the above characteristics associated with some systems, there is a need for an analyte sensor system configured such that the analyte sensor and the analyte sensor electronics are electrically and mechanically coupled to each other before the analyte sensor is implanted in the user or host. The present disclosure generally relates to controlling the operation of sensor electronics for wireless communication of analyte data collected using an analyte sensor system. More specifically, the present disclosure relates to a number of methods for controlling such operation in an analyte sensor system in which the analyte sensor is connected both electrically and mechanically to the analyte sensor electronics before the analyte sensor is implanted in the host. In view of the above characteristics associated with some systems, there is a need for an analyte sensor system configured such that the analyte sensor and the analyte sensor electronics are electrically and mechanically coupled to each other before the analyte sensor is implanted in the user or host. The present disclosure generally relates to controlling the operation of sensor electronics for wireless communication of analyte data collected using an analyte sensor system. More specifically, the present disclosure relates to a number of methods for controlling such operation in an analyte sensor system in which the analyte sensor is connected both electrically and mechanically to the analyte sensor electronics before the analyte sensor is implanted in the host. Systems, methods, apparatuses, and devices for using the technology of

Means for Solving the Problem

[0009] The present disclosure is associated with systems, methods, devices, and many other aspects and embodiments and has a number of advantages. For example, an analyte sensor system configured such that the analyte sensor is connected to the analyte sensor electronic circuit before implantation may not require much user interaction, is smaller, simpler, more sophisticated, and / or may be less expensive, and may have fewer problems with encapsulation, deployment, and connection. For example, problems with connection, alignment, retention, and separation of the analyte sensor associated with analyte sensor connection during percutaneous implantation can be avoided. As a further example, in systems that are not designed to be pre-connected, when the analyte sensor and the analyte sensor electronic circuit are brought together in the field, it may be necessary to create a seal between the analyte sensor electronic circuit and the analyte sensor and / or their housings. However, in a pre-connected system, this seal can be accomplished during system manufacture. Therefore, malfunctions that may occur as a result of the insertion of the analyte sensor can be avoided. Another exemplary advantage of a pre-connected system is that it may be advantageous for the analyte sensor system to transition to an active state so that the analyte sensor can capture analyte measurements shortly before being implanted by the user. This enables the analyte processing algorithm to more accurately evaluate the sensor implantation time, and thus more accurately process the analyte value of the sensor signal.

[0010] ​​​​There may also be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. Additionally, monitoring the analyte sensor prior to implantation may cause undesirable changes (e.g., deviation from calibration values) in the analyte sensor. Therefore, monitoring the analyte sensor electronics based solely on the analyte sensor signal may not be very suitable as the primary or only means for the purpose of operation in certain cases. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system. In addition, there may be several issues associated with implementing a pre-connected analyte sensor system. For example, in a non-pre-connected system, the analyte sensor electronic circuit may be used to monitor for an electrical signal indicating the presence of the analyte sensor within the circuit to operate the analyte sensor system. However, in a pre-connected system, such a signal may be subject to noise and may lead to false triggering / operation of the system.

[0011] Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. In addition, a pre-connected system should provide an improved user experience, for example, by reducing and / or eliminating user steps associated with the connection and / or reducing and / or eliminating the possibility of combining incompatible sensors and electronics. Further, for example, a pre-connected system and solution may lead to a reduction in analyte data dropout in a closed-loop system (e.g., an automated insulin delivery system). Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. Therefore, alternative and / or additional means for operating the analyte sensor system may be used. However, such means should be robust against false wake-up events, should maintain accurate analyte sensor calibration, should not consume a large amount of power, and should enable a sufficiently rapid wake-up of the analyte sensor system. , and related or similar systems and applications), can more quickly and easily initiate a connection (e.g., a wireless connection). Also, in scenarios of healthcare providers (e.g., physicians or other clinics), the time associated with setting up such a system (e.g., including the time for implanting sensors into a user's body and / or for activating or establishing the operation of an analyte sensor electronic device) can be substantially reduced. In addition, in scenarios of healthcare providers (e.g., physicians or other clinics), etc., the time associated with setting up such a system (e.g., including the time for implanting sensors into a user's body and / or for activating or establishing the operation of an analyte sensor electronic device) can be substantially reduced. Embodiments of the present disclosure overcome these problems and provide the above-mentioned advantages by using a number of methods for detecting and verifying conditions for operating an analyte sensor electronic circuit.

[0012] By using one or more verification methods, embodiments of the present disclosure provide a system that is more robust against false wake-ups, thus saving power, providing better overall reliability, and providing the other advantages described above. According to embodiments of the present disclosure, in order to implement a robust wake-up or operation procedure and avoid false wake-up events, a number of indicators of analyte sensor insertion are used to trigger the analyte sensor electronic circuit to exit a lower power state. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. Embodiments of the present disclosure overcome these problems and provide the above-mentioned advantages by using a number of methods for detecting and verifying conditions for operating an analyte sensor electronic circuit. By using one or more verification methods, embodiments of the present disclosure provide a system that is more robust against false wake-ups, thus saving power, providing better overall reliability, and providing the other advantages described above. According to embodiments of the present disclosure, in order to implement a robust wake-up or operation procedure and avoid false wake-up events, a number of indicators of analyte sensor insertion are used to trigger the analyte sensor electronic circuit to exit a lower power state. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device. In many embodiments, the system is generally designed to avoid changing the characteristics of the analyte sensor and to operate in a manner that is robust against signal noise (e.g., resulting from humidity, temperature, vibration, etc.) that may be experienced before the analyte sensor is implanted and is suitable for a low-power battery-powered device.

[0013] Regarding a number of techniques that can be used to detect operation events of an analyte sensor electronic circuit And such techniques can generally be divided into those that utilize a primary signal and those that utilize a secondary signal. As referred to herein, a primary signal generally relates to, correlates with, is derived from, characterizes, and / or describes signals related to analyte information obtained from a host using an analyte sensor. As referred to in this specification, a secondary signal can generally be related to information collected using an analyte sensor system, where the information collected is information other than the primary signal(s) (e.g., the information collected is not the information used in the primary signal capacity to describe the relationship between the signal and the analyte information). A secondary signal or information may also be collected using an analyte sensor (e.g., one or more electrodes) and / or other means. Such other means may include circuitry or components internal or external to the analyte sensor system, as described in more detail herein. In addition, a secondary signal or information may be collected using the analyte sensor system and / or external components alone or in conjunction with user interaction. For example, one technique can be used to check another technique that may be affected by noise or false triggers, e.g., one or more primary signals can be used to check one or more secondary signals, and combining a number of techniques that can be used to detect operating events of the electronic circuitry of an analyte sensor can increase the robustness of the system against false wake-ups. In some cases, a primary signal (e.g., an analyte value or signal that can be its representative value such as voltage, current,

[0014] count, or other signal) is ​​​​ Collected using a physical sensor signal (e.g., impedance, capacitance of an analyte sensor, etc.) / Can be used in combination with a secondary signal that can be derived. In some cases, the primary signal is Derived / collected using means other than or in addition to the analyte sensor Can be used in combination with one or more secondary signals. In an embodiment, the primary signal information can be Combined with the secondary signal information, and the secondary signal information may be or include one or more non-analyte sensor signals or information In an embodiment, the analyte sensor system Can use the primary signal(s) collected / derived using the analyte sensor and / or The secondary signal(s), and information collected / derived using means other than the analyte sensor (e.g., an accelerometer signal or other techniques as described herein) And can compare the foregoing over one or more periods for the purpose of operating the analyte sensor system. In this way, embodiments of the present disclosure can more accurately evaluate the operating time while maintaining high battery efficiency, lower power modes, and robust sensor performance, and / or better avoid and / or reduce false wake-ups in a pre-connected analyte sensor system

[0015] A first aspect of the present disclosure includes a system for controlling the operation of an analyte sensor electronic circuit This system includes an analyte sensor that is electrically and mechanically coupled to the analyte sensor electronic circuit before transitioning the system to an operating state. The analyte sensor electronic circuit is adapted to perform several operations. One such operation is when the system is in a lower power state ​​​​​​​is to trigger a display for ending and transitioning to an operating state. This display is triggered based on a threshold associated with the deployment of the system. Another such operation is to cause the analyte sensor to collect information related to the level of the analyte in the host in response to the display, by generating a control signal that can be made to operate. Yet another such operation is to generate a comparison between the information related to the level of the analyte in the host and the conditions. The system stem ends the lower power state and transitions to the operating mode based on the display being triggered and the comparison indicating that the level of the analyte in the host meets the conditions. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the analyte sensor electronic circuit is further adapted to cause the system to trigger the display in response to the threshold being met for at least a predetermined time. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the display is a signal generated using one or more of an operation detection circuit and an operation detection component adapted to detect one or more of the insertion of the analyte sensor into the host and the deployment of the system. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the control signal causes the potentiostat to apply a voltage bias to the analyte sensor, thereby causing the level of the analyte in the host Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the control signal causes the potentiostat to apply a voltage bias to the analyte sensor, thereby causing the level of the analyte in the host Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the control signal causes the potentiostat to apply a voltage bias to the analyte sensor, thereby causing the level of the analyte in the host Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the control signal causes the potentiostat to apply a voltage bias to the analyte sensor, thereby causing the level of the analyte in the host Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the control signal causes the potentiostat to apply a voltage bias to the analyte sensor, thereby causing the level of the analyte in the host

[0016] Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the analyte sensor electronic circuit is further adapted to cause the system to trigger the display in response to the threshold being met for at least a predetermined time. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the analyte sensor electronic circuit is further adapted to cause the system to trigger the display in response to the threshold being met for at least a predetermined time. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the analyte sensor electronic circuit is further adapted to cause the system to trigger the display in response to the threshold being met for at least a predetermined time. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the analyte sensor electronic circuit is further adapted to cause the system to trigger the display in response to the threshold being met for at least a predetermined time.

[0017] Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the analyte sensor electronic circuit is further adapted to cause the system to trigger the display in response to the threshold being met for at least a predetermined time. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the display is a signal generated using one or more of an operation detection circuit and an operation detection component adapted to detect one or more of the insertion of the analyte sensor into the host and the deployment of the system. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the display is a signal generated using one or more of an operation detection circuit and an operation detection component adapted to detect one or more of the insertion of the analyte sensor into the host and the deployment of the system. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the display is a signal generated using one or more of an operation detection circuit and an operation detection component adapted to detect one or more of the insertion of the analyte sensor into the host and the deployment of the system.

[0018] Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the analyte sensor electronic circuit is further adapted to cause the system to trigger the display in response to the threshold being met for at least a predetermined time. Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the control signal causes the potentiostat to apply a voltage bias to the analyte sensor, thereby causing the level of the analyte in the host Although generally applicable, in a particular implementation of the first aspect that may be particularly applicable in relation to any other implementation of the first aspect, the control signal causes the potentiostat to apply a voltage bias to the analyte sensor, thereby causing the level of the analyte in the host A signal that is operable to cause an analyte sensor to collect information related thereto.

[0019] Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, after the system transitions to an operating state, the system continues to collect information related to the level of analyte within the host and communicates the information to one or more display devices or one or more partner devices. Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, the threshold is typically related to the level of a known analyte present in a human host.

[0020] Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, the display is based on (1) the detected proximity between the analyte sensor electronics and a reference object, (2) the temperature monitored using the analyte sensor electronics, (3) the output of the accelerometer of the analyte sensor electronics, (4) the response generated using wireless signaling transmitted or received by the analyte sensor device, (5) the detected change in air pressure measured by the analyte sensor electronics, (6) the audio information monitored by the analyte sensor electronics, (7) the signal generated by the analyte sensor electronics in response to photons detected by the analyte sensor electronics, (8) the conductivity measured between two terminals of the analyte sensor electronics, (9) a mechanical switch located on or within the housing of the analyte sensor electronics, (10) a component, the movement of the component Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect.

[0021] Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, the display is based on (1) the detected proximity between the analyte sensor electronics and a reference object, (2) the temperature monitored using the analyte sensor electronics, (3) the output of the accelerometer of the analyte sensor electronics, (4) the response generated using wireless signaling transmitted or received by the analyte sensor device, (5) the detected change in air pressure measured by the analyte sensor electronics, (6) the audio information monitored by the analyte sensor electronics, (7) the signal generated by the analyte sensor electronics in response to photons detected by the analyte sensor electronics, (8) the conductivity measured between two terminals of the analyte sensor electronics, (9) a mechanical switch located on or within the housing of the analyte sensor electronics, (10) a component, the movement of the component Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, the display is based on (1) the detected proximity between the analyte sensor electronics and a reference object, (2) the temperature monitored using the analyte sensor electronics, (3) the output of the accelerometer of the analyte sensor electronics, (4) the response generated using wireless signaling transmitted or received by the analyte sensor device, (5) the detected change in air pressure measured by the analyte sensor electronics, (6) the audio information monitored by the analyte sensor electronics, (7) the signal generated by the analyte sensor electronics in response to photons detected by the analyte sensor electronics, (8) the conductivity measured between two terminals of the analyte sensor electronics, (9) a mechanical switch located on or within the housing of the analyte sensor electronics, (10) a component, the movement of the component Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, the display is based on (1) the detected proximity between the analyte sensor electronics and a reference object, (2) the temperature monitored using the analyte sensor electronics, (3) the output of the accelerometer of the analyte sensor electronics, (4) the response generated using wireless signaling transmitted or received by the analyte sensor device, (5) the detected change in air pressure measured by the analyte sensor electronics, (6) the audio information monitored by the analyte sensor electronics, (7) the signal generated by the analyte sensor electronics in response to photons detected by the analyte sensor electronics, (8) the conductivity measured between two terminals of the analyte sensor electronics, (9) a mechanical switch located on or within the housing of the analyte sensor electronics, (10) a component, the movement of the component Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, the display is based on (1) the detected proximity between the analyte sensor electronics and a reference object, (2) the temperature monitored using the analyte sensor electronics, (3) the output of the accelerometer of the analyte sensor electronics, (4) the response generated using wireless signaling transmitted or received by the analyte sensor device, (5) the detected change in air pressure measured by the analyte sensor electronics, (6) the audio information monitored by the analyte sensor electronics, (7) the signal generated by the analyte sensor electronics in response to photons detected by the analyte sensor electronics, (8) the conductivity measured between two terminals of the analyte sensor electronics, (9) a mechanical switch located on or within the housing of the analyte sensor electronics, (10) a component, the movement of the component Although it may be generally applicable, it is particularly applicable in relation to any other implementation of the first aspect. In a particular implementation of the first aspect, which may also be particularly applicable in relation to any other implementation of the first aspect, the display is based on (1) the detected proximity between the analyte sensor electronics and a reference object, (2) the temperature monitored using the analyte sensor electronics, (3) the output of the accelerometer of the analyte sensor electronics, (4) the response generated using wireless signaling transmitted or received by the analyte sensor device, (5) the detected change in air pressure measured by the analyte sensor electronics, (6) the audio information monitored by the analyte sensor electronics, (7) the signal generated by the analyte sensor electronics in response to photons detected by the analyte sensor electronics, (8) the conductivity measured between two terminals of the analyte sensor electronics, (9) a mechanical switch located on or within the housing of the analyte sensor electronics, (10) a component, the movement of the component adapted to change the connection between two conductive elements of an analyte sensor electronic circuit in response to and (11) generated using one or more of the measured strains is.

[0022] While generally applicable, it is particularly applicable in connection with any other implementation of the first aspect In a particular implementation of the first aspect, which may also be applicable, the system terminates the lower power state based on a determination that the level of analyte in the host exceeds a threshold.

[0023] While generally applicable, it is particularly applicable in connection with any other implementation of the first aspect In a particular implementation of the first aspect, which may also be applicable, the analyte sensor electronic circuit causes the system to trigger a display in response to programmed period conditions being met. is further adapted.

[0024] While generally applicable, it is particularly applicable in connection with any other implementation of the first aspect In a particular implementation of the first aspect, which may also be applicable, information related to the level of analyte in the host is used to generate a detected count. Further, the condition includes a threshold characteristic of the count. If the comparison indicates that the detected count has reached the threshold, the system terminates the lower power state and transitions to an operating mode.

[0025] A second aspect of the present disclosure includes a method for controlling an analyte sensor electronic circuit. This method includes the analyte sensor electronic circuit obtaining a first signal generated using one or more of the analyte sensor and the secondary sensor This method is by the analyte sensor electronic circuit Based on the first signal thus obtained, determine whether the first condition is met. This includes. This method also, in response to the first condition being met, an analyte sensor The electronic circuit includes operating an analyte measurement circuit. Additionally, this method The path includes collecting information related to the analyte value in the host using an analyte sensor. The analyte sensor was coupled to the analyte sensor electronics before the analyte sensor was embedded in the host. This method also includes the analyte sensor electronics determining whether information related to the analyte value in the host meets a second condition.

[0026] Additionally, the method according to the second aspect, in response to the analyte sensor electronics determining that information related to the analyte value in the host meets the second condition, includes the sensor electronics exiting a lower power consumption mode. Alternatively, the method, in response to the analyte sensor electronics determining that information related to the analyte value in the host does not meet the second condition, includes the analyte sensor electronics remaining in a lower power consumption mode and obtaining a second electrical signal indicating whether the first condition is met.

[0027] While generally applicable, in a particular implementation of the second aspect that may be particularly applicable in relation to any other implementation of the second aspect, the second condition is met if information related to the analyte value indicates that the level of the analyte value in the host meets a threshold.

[0028] While generally applicable, in a particular implementation of the second aspect that may be particularly applicable in relation to any other implementation of the second aspect, the first condition is the analyte electronics relative to a reference point ​​​​​​​​​ Represents proximity of a circuit.

[0029] While generally applicable, it may be particularly applicable in connection with any other implementation of the second aspect. In a particular implementation of the second aspect, which may also be particularly applicable in connection with any other implementation of the second aspect, the first condition represents the level of acceleration detected using an accelerometer.

[0030] While generally applicable, it may be particularly applicable in connection with any other implementation of the second aspect. In a particular implementation of the second aspect, which may also be particularly applicable in connection with any other implementation of the second aspect, the first condition is related to one or more electrical characteristics measured for an acceleration sensor.

[0031] A third aspect of the present disclosure includes a system for monitoring an analyte within a host. The system includes an analyte sensor. The analyte sensor includes one or more electrodes adapted to collect information related to the level of the analyte within the host. The system also includes sensor electronics mechanically and electrically coupled to the analyte sensor prior to the analyte sensor being embedded in the host. The sensor electronics is adapted to generate a secondary indicator using the first condition and a measurement of an electrical signal passing between at least two of the one or more electrodes. The sensor electronics is further adapted to cause the system to transition to an active state in response to the sensor electronics generating a confirmation of the secondary indicator using the second condition and information related to the level of the analyte within the host.

[0032] While generally applicable, it may be particularly applicable in connection with any other implementation of the third aspect. In a particular implementation of the third aspect, which may also be particularly applicable in connection with any other implementation of the third aspect, the sensor electronics is of one of the one or more electrodes. Using the measured value of the electrical signal passing between at least two of them, one or more of the impedance, capacitance, voltage, and current associated with one or more electrodes are determined and further adapted.

[0033] A fourth aspect of the present disclosure includes a system for monitoring an analyte within a host. The system includes an analyte sensor electronic circuit. The system further includes an analyte sensor that is mechanically and electrically coupled to the analyte sensor electronic circuit before the analyte sensor is embedded in the host. Additionally, the system includes an actuation detection circuit coupled to the analyte sensor. The actuation detection circuit is adapted to generate a control signal operable to cause the analyte sensor to obtain information related to the level of the analyte within the host. The control signal is generated in response to an electrical signal indicating that a first condition is satisfied. The analyte sensor electronic circuit is adapted to cause the system to change state when the level of the analyte within the host satisfies a second condition and the electrical signal indicates that the first condition is satisfied.

[0034] While generally applicable, in a particular implementation of the fourth aspect, which may be particularly applicable in connection with any other implementation of the fourth aspect, the indication that the first condition is satisfied is generated using one or more of a parameter, an input, and / or a variable. For example, any of the following may be used, alone or in combination, to generate the indication. The indication may be generated using the detected proximity between the analyte sensor electronic circuit and a reference object. The indication may be generated using the temperature monitored by the analyte sensor electronic circuit. ​ This indication may be generated using the output of an accelerometer of the analyte sensor electronics. In an embodiment, the indication may be transmitted or received by the analyte sensor electronics. The indication may be generated using a response generated using the signaling. The analyte may be generated using detected changes in air pressure measured by the analyte sensor electronics. Additionally, audio information that may be monitored by the analyte sensor electronics may be used to generate an indication. Additionally, the indication may be generated in response to photons detected by the analyte sensor electronics. The signal generated by the analyte sensor electronics may also be used to generate the signal. The conductivity measured between the two terminals of the analyte sensor electronics is used to generate the display. In some cases, the indicia may be located on or in the housing of the analyte sensor electronics. In an embodiment, the indication may be generated using a mechanical switch located within the housing. In response to the movement of the component, a connection is formed between two conductive elements of the analyte sensor electronics. The display may be generated using a component adapted to change the measurement. The distortion may be generated using the

[0035] A fifth aspect of the present disclosure includes a system for monitoring an analyte in a host. The system includes an analyte sensor electronics. The system includes an analyte sensor embedded in a host. The method further includes coupling the analyte sensor to the analyte sensor electronics prior to the injection of the analyte sensor. In addition, the system includes an operational detection circuit coupled to the analyte sensor. The operational detection circuit includes: a secondary sensor coupled to the analyte sensor and monitoring the secondary sensor according to a sampling frequency; and increasing the sampling frequency in response to the first event detected using the secondary sensor. The actuation detection circuit is adapted to increase the sampling frequency. and controlling in response to detecting a second event. and generating a control signal when the analyte sensor detects the presence of the analyte. When implanted in a test tube, measurements are taken to obtain information indicative of the level of an analyte in the host. The analyte sensor electronics is operable to cause the analyte sensor to in response to information indicative of a level of the analyte in the sample satisfying the condition, and The system further includes a second event detecting circuit configured to change state in response to detecting the second event. The present invention is further adapted to cause the

[0036] It may be generally applicable, but may be particularly applicable in relation to any other implementation of the fifth aspect. In a particular implementation of the fifth aspect, the sampling frequency is set to 100 Hz. The classification of one or more of the first event and the second event is determined by the component. Therefore, it is set.

[0037] A sixth aspect of the present disclosure includes a circuit for controlling the operation of the analyte sensor system. The path is adapted to indicate whether a signal at an input terminal of the detection circuit achieves a condition. The detection circuit includes a detection circuit configured to detect when the detection circuit indicates that the signal achieves the condition. and further adapted to trigger the analyte system to exit the lower power state if The circuit also controls coupling between the input terminal of the detection circuit and the first terminal of the analyte sensor. The analyte sensor includes a first switch element adapted to control a first voltage of the analyte in the host. is adapted to collect information related to a level. The circuit is a second switch element adapted to control a connection between a first terminal of an analyte sensor and a first terminal of a potentiostat. The potentiostat is adapted to apply a voltage bias to the analyte sensor that causes the analyte sensor to collect information related to a level of an analyte within a host. An input terminal of the detection circuit is coupled to a second terminal of the analyte sensor and to a second terminal of the potentiostat. The circuit is adapted to cause the second switch element to connect a first terminal of the analyte sensor to the first terminal of the potentiostat at a first point in time and to cause the first switch element to disconnect the input terminal of the detection circuit from the first terminal of the analyte sensor, including to generate an additional detectable event for operating the analyte sensor system. At a second point in time, the circuit is adapted to cause the second switch element to disconnect the first

[0038] terminal of the analyte sensor from the first terminal of the potentiostat and to cause the first switch element to connect the input terminal of the detection circuit to the first terminal of the analyte sensor.

[0039] In a particular implementation of the sixth aspect, which may be generally applicable but is particularly applicable in connection with any other The son is adapted to be coupled to the first terminal via a resistive element.

[0040] Although it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the circuit further includes a third switching element adapted to couple the input terminal of the detection circuit to a second reference voltage. When the third switching element couples the input terminal of the detection circuit to the second reference voltage, the capacitive element discharges.

[0041] Although it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, when the third switching element couples the input terminal of the detection circuit to the second reference voltage, the capacitive element discharges. When the third switching element couples the input terminal of the detection circuit to the second reference voltage, the capacitive element discharges.

[0042] Although it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the terminals of the third switching element are coupled to a clock that causes the third switching element to periodically couple the input terminal of the detection circuit to the second reference voltage. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the terminals of the third switching element are coupled to a clock that causes the third switching element to periodically couple the input terminal of the detection circuit to the second reference voltage. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the terminals of the third switching element are coupled to a clock that causes the third switching element to periodically couple the input terminal of the detection circuit to the second reference voltage.

[0043] Although it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the first switching element is driven by a common signal, and the second switching element is driven by an inverted version of the common signal. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the first switching element is driven by a common signal, and the second switching element is driven by an inverted version of the common signal.

[0044] Although it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the first switching element and the second switching element are driven by a common signal and have opposite polarities. In a specific implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the first switching element and the second switching element are driven by a common signal and have opposite polarities.

[0045] While it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a particular implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the voltage at the input terminal of the detection circuit indicates the current between the first terminal and the second terminal of the analyte sensor when the analyte sensor is embedded in the host.

[0046] While it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a particular implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the reference terminal of the detection circuit is coupled to a first reference voltage. The detection circuit includes a comparator.

[0047] While it may be generally applicable, it is particularly applicable in relation to any other implementation form of the sixth aspect. In a particular implementation form of the sixth aspect, which may also be particularly applicable in relation to any other implementation form of the sixth aspect, the second voltage reference is ground.

[0048] In some embodiments, an analyte sensor system is provided. The analyte sensor system includes an analyte sensor. The analyte sensor system includes a state machine configured such that a first potential is applied across the analyte sensor during a first sampling state and a second potential is applied across the analyte sensor during a second sampling state. The analyte sensor system includes an analyte sensor measurement circuit configured to generate a first digital count corresponding to a first current flowing through the analyte sensor during the first sampling state based on the application of the first potential and to generate a second digital count corresponding to a second current flowing through the analyte sensor during the second sampling state based on the application of the second potential. The analyte sensor system includes a comparison circuit configured to compare the second digital count with the first digital count. The analyte sensor system includes a comparison circuit configured to compare the second digital count with the first digital count. ​​​​​​​​​​Determine a first difference between the and include a detection circuit configured to generate a controller wake-up signal in response to at least the first difference that meets a threshold. The analyte sensor system is configured to enter a lower power state during at least a first sampling state, a second sampling state, and a duration of determination of the first difference, and to transition from the lower power state to an operating state in response to a controller wake-up signal. It includes a controller. The controller is configured to determine the impedance of the analyte sensor based at least in part on the first difference. In some embodiments, the state machine is configured to cause the start of a first potential applied across the analyte sensor during a first delay state immediately preceding the first sample state, and the analyte sensor measurement circuit is configured to interrupt the generation of a digital count during the first delay state.

[0049] In some embodiments, the state machine is configured to cause the start of a second potential applied across the analyte sensor during a second delay state immediately preceding the second sample state, and the analyte sensor circuit is configured to interrupt the generation of a digital count during the second delay state. In some embodiments, the state machine is configured to apply a zero potential across the analyte sensor during a third delay state following the second sampling state,

[0050] and the analyte sensor measurement circuit is configured to interrupt the generation of a digital count during the third delay state.

[0051]

[0052] ​​​​​​​​In some embodiments, the detection circuit is configured to store a first digital count and includes a first sample buffer that has been sampled. In some embodiments, the detection circuit receives the first digital count from the first sample buffer and includes a differentiator configured to receive a second digital count from the analyte sensor measurement circuit and determine a first difference.

[0053] In some embodiments, the detection circuit includes an adder configured to generate a sum of the first difference and at least a second difference between a third digital count and a fourth digital count. The third digital count corresponds to a third current flowing through the analyte sensor during a subsequent stage of the first sampling state, and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a subsequent stage of the second sampling state. In some embodiments, the detection circuit is configured to generate a controller wake-up signal in response to the sum of at least the first difference and the second difference meeting a threshold.

[0054] In some embodiments, the controller is configured to define at least one parameter of the state machine before transitioning to a lower power state. In some embodiments, in a first mode of operation of the analyte sensor system, a first potential is zero volts and a second potential is a predetermined amount greater than the first potential. In a second mode of operation of the analyte sensor system, the first potential is the same as the potential applied across the analyte sensor to determine the analyte concentration within the host, and the second potential is a predetermined amount greater than the first potential.

[0055] ​​​In some embodiments, a method for controlling an analyte sensor system is provided. The method utilizes a state machine to detect when a first potential is applied to an analyte sensor during a first sampling state. and during the second sampling state, a second potential is applied across the analyzer. The method includes applying a voltage across the analyte sensor. a first potential path to activate the analyte sensor during a first sampling state based on application of the first potential to the analyte sensor; generating a first digital count corresponding to the first current flowing and upon application of the second potential; A second current corresponding to a second current through the analyte sensor during a second sampling state based on the second current. The method utilizes a detection circuit to generate a second digital count. determining a first difference between the first digital count and the first digital count, and generating a controller wake-up signal in response to the threshold being satisfied. The method includes at least a first sampling state, a second sampling state, and a first transition to a lower power state for the duration of the determination of the difference between the power consumption and the controller transitioning from a lower power state to an operating state in response to a backup signal; determining an impedance of the analyte sensor based at least in part on the impedance of the analyte sensor; This includes having a roller do it.

[0056] In some embodiments, the method includes: commencing application of a first potential across the analyte sensor during a first delay state; and ceasing generation of a digital count by the analyte sensor measurement circuitry.

[0057] In some embodiments, the method starts applying a second potential across the analyte sensor between a second delay state immediately prior to the second sample state and, during the second delay state, interrupts generation of a digital count by the analyte sensor measurement circuit. In some embodiments, the method utilizes a state machine to cause a zero potential to be applied across the analyte sensor between a third delay state following the second sample state and, during the third delay state, interrupts generation of a digital count by the analyte sensor measurement circuit. In some embodiments, the method includes storing the first digital count in a first sample buffer before determining the first difference. In some embodiments, the method includes receiving the first digital count from the first sample buffer by a differentiator, receiving a second digital count from the analyte sensor measurement circuit by the differentiator, and determining the first difference using the differentiator.

[0058] In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state. In some embodiments, the method includes using a state machine to cause a zero potential to be applied across the analyte sensor between a third delay state following the second sample state and, during the third delay state, interrupts generation of a digital count by the analyte sensor measurement circuit. In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state. In some embodiments, the method includes using a state machine to cause a zero potential to be applied across the analyte sensor between a third delay state following the second sample state and, during the third delay state, interrupts generation of a digital count by the analyte sensor measurement circuit.

[0059] In some embodiments, the method includes storing the first digital count in a first sample buffer before determining the first difference. In some embodiments, the method includes receiving the first digital count from the first sample buffer by a differentiator, receiving a second digital count from the analyte sensor measurement circuit by the differentiator, and determining the first difference using the differentiator. In some embodiments, the method includes storing the first digital count in a first sample buffer before determining the first difference. In some embodiments, the method includes receiving the first digital count from the first sample buffer by a differentiator, receiving a second digital count from the analyte sensor measurement circuit by the differentiator, and determining the first difference using the differentiator. In some embodiments, the method includes receiving the first digital count from the first sample buffer by a differentiator, receiving a second digital count from the analyte sensor measurement circuit by the differentiator, and determining the first difference using the differentiator. In some embodiments, the method includes receiving the first digital count from the first sample buffer by a differentiator, receiving a second digital count from the analyte sensor measurement circuit by the differentiator, and determining the first difference using the differentiator. In some embodiments, the method includes receiving the first digital count from the first sample buffer by a differentiator, receiving a second digital count from the analyte sensor measurement circuit by the differentiator, and determining the first difference using the differentiator.

[0060] In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state. In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state. In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state. In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state. In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state.

[0061] In some embodiments, the method includes using an integrator to generate a sum of the first difference and a second difference between at least a third digital count and a fourth digital count, where the third digital count corresponds to a third current flowing through the analyte sensor during a stage subsequent to the first sampling state and the fourth digital count corresponds to a fourth current flowing through the analyte sensor during a stage subsequent to the second sampling state. Responsive to meeting a threshold value, generating a controller wake-up signal including.

[0062] In some embodiments, the method includes using a controller to define at least one parameter of a state machine before transitioning to a lower power state.

[0063] In some embodiments, in a first operating mode of an analyte sensor system, a first potential is zero volts and a second potential is greater than the first potential by a predetermined amount. In a second operating mode of the analyte sensor system, the first potential is the same as the potential applied across the analyte sensor to determine the analyte concentration within the host, and the second potential is greater than the first potential by a predetermined amount.

[0064] In some embodiments, a system for controlling the operation of an analyte sensor electronics circuit is provided. The system includes an analyte sensor, a magnetic sensor configured to trigger a wake signal in response to a magnet being brought sufficiently close to the magnetic sensor, and an analyte sensor electronics circuit configured to terminate a lower power state and transition to an operating state in response to the wake signal and to receive a display of one or more analyte concentration values from the analyte sensor in response to transitioning to the operating state.

[0065] In some embodiments, the magnet is disposed on a display device configured to display one or more analyte concentration values. In some embodiments, the magnetic sensor is configured to trigger a wake signal in response to the magnet being moved relative to the magnetic sensor with at least one of a predetermined movement and a predetermined spatial orientation. ​​​​​​​​​​​​​

[0066] In some embodiments, a display device is provided that is configured to display one or more analyte concentration values. The display device includes a microphone configured to generate one or more audio waveforms of sounds emitted by an applicator during deployment of the analyte sensor system. The display device includes a processor configured to execute an application while the applicator is deploying the analyte sensor system. The application is configured to analyze the one or more audio waveforms and, based on analyzing the one or more audio waveforms, identify either a successful deployment or a failed deployment of the analyte sensor system. The display device includes a display configured to display at least one of a first display for a successful deployment in response to the application identifying a successful deployment and a second display for a failed deployment in response to the application identifying a failed deployment.

[0067] In some embodiments, analyzing the one or more audio waveforms includes identifying at least a portion of the one or more audio waveforms that indicate that at least a portion of the applicator is performing a known movement for a successful deployment.

[0068] This summary is intended to provide an overview of the subject matter of this patent application. It is not intended to provide an exclusive or exhaustive explanation of the disclosure. The detailed description is included to provide further information regarding this patent application. Other aspects of the disclosure will be apparent to those of ordinary skill in the art upon reading and understanding the following detailed description and viewing the drawings that form a part thereof, each of which should not be construed in a limiting sense. ​​​​​​​​​​​​​​​​

Brief Description of the Drawings

[0069] Further aspects of the present disclosure will be more readily understood by considering the following detailed description of the various disclosed embodiments in conjunction with the accompanying drawings.

[0070]

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Figure 15

[0071] The drawings are described in more detail in the following description and examples, and are provided for purposes of illustration only, merely depicting typical or exemplary embodiments of the present disclosure. The drawings are not intended to be comprehensive or to limit the disclosure to the exact form disclosed. The present disclosure , may be implemented with modifications or alterations, and it is understood that the present disclosure may be limited only by the claims and their equivalents. It should also be understood that it can be limited only by the equivalents.

[0072] Embodiments of the present disclosure are directed to systems, methods, and devices for wireless communication of analyte data. In various aspects described herein, the analyte data is glucose data generated by an analyte sensor system configured to connect to a display device, a partner device (e.g., a medical device such as an insulin pump), or other remotely connectable devices. More specifically, by implementing aspects of the present disclosure, including the systems, methods, apparatuses, and devices described herein, which provide increased robustness against malfunctions or other undesirable operations, wake-ups, and / or associated mode changes or state changes to components of the analyte sensor system, the accuracy, robustness, and / or power management of the analyte sensor system for wireless communication with a display device, one or more partner devices, and / or other (e.g., electronic) devices can be improved. Further, by implementing aspects of the present disclosure, it may also be possible to improve the performance of the analyte sensor system with respect to its lifespan and usefulness. In various developments described herein, the analyte data is glucose data generated by an analyte sensor system configured to connect to a display device, a partner device (e.g., a medical device such as an insulin pump), or other remotely connectable devices. , a partner device (e.g., a medical device such as an insulin pump), or other remotely connectable devices. It is generated by an analyte sensor system configured to connect to a display device, a partner device (e.g., a medical device such as an insulin pump), or other remotely connectable devices. More specifically, it is glucose data generated by an analyte sensor system configured to connect to a display device, a partner device (e.g., a medical device such as an insulin pump), or other remotely connectable devices. Malfunctions or other undesirable operations, wake-ups, and / or associated mode changes or state changes to components of the analyte sensor system. Increasing robustness against malfunctions or other undesirable operations, wake-ups, and / or associated mode changes or state changes to components of the analyte sensor system. By implementing aspects of the present disclosure, including the systems, methods, apparatuses, and devices described herein, which provide increased robustness against malfunctions or other undesirable operations, wake-ups, and / or associated mode changes or state changes to components of the analyte sensor system, the accuracy, robustness, and / or power management of the analyte sensor system for wireless communication with a display device, one or more partner devices, and / or other (e.g., electronic) devices can be improved. A display device, one or more partner devices, and / or other (e.g., electronic) devices. The accuracy, robustness, and / or power management of the analyte sensor system for wireless communication with a display device, one or more partner devices, and / or other (e.g., electronic) devices can be improved. Further, by implementing aspects of the present disclosure, it may also be possible to improve the performance of the analyte sensor system with respect to its lifespan and usefulness. It may also be possible to improve the performance of the analyte sensor system with respect to its lifespan and usefulness.

[0073] Details of some exemplary embodiments of the systems, methods, and devices of the present disclosure are described in this description and, in some cases, in other parts of the present disclosure. Other features, purposes, and advantages of the present disclosure will become apparent to those skilled in the art upon consideration of the present disclosure, description, drawings, examples, and claims. Such additional systems, methods, devices The other features, purposes, and advantages of the present disclosure will become apparent to those skilled in the art upon consideration of the present disclosure, description, drawings, examples, and claims. will become apparent to those skilled in the art upon consideration of the present disclosure, description, drawings, examples, and claims. Such additional systems, methods, devices , features, and advantages are all included (either explicitly or by reference) in this description and are intended to be within the scope of the present disclosure and protected by one or more of the appended claims.

[0074] Overview and exemplary configuration of the system FIG. 1 depicts, for example, a system 100 that may be used in connection with embodiments of the present disclosure involving collecting, monitoring, and / or providing information regarding analyte values present in a user's body, including the user's blood glucose level. System 100 includes display devices 110, 120, 130, and 140, a partner device 136, and / or an analyte sensor system 8 that may be communicatively coupled to a server system 134. The analyte sensor system 8 in the depicted embodiment includes a sensor electronics module 12 and an analyte sensor 10 associated with the sensor electronics module 12. The analyte sensor electronics module 12 may be electrically and mechanically coupled to the analyte sensor 10 before the analyte sensor 10 is implanted in a user or host. Thus, the analyte sensor 10 may not require the user to couple the analyte sensor electronics module 12 to the analyte sensor 10. For example, the analyte sensor electronics module 12 may be physically / mechanically and electrically coupled to the analyte sensor 10 during manufacturing, and this physical / mechanical and electrical connection

[0075] may be maintained during shipment, storage, insertion, use, and removal of the analyte sensor system 8. Thus, the electromechanically connected components of the analyte sensor system 8 ( e.g., the analyte sensor 10 and the analyte sensor electronics module 12) are "pre-connected" and may not require the user to couple the analyte sensor electronics module 12 to the analyte sensor 10. For example, the analyte sensor electronics module 12 may be physically / mechanically and electrically coupled to the analyte sensor 10 during manufacturing, and this physical / mechanical and electrical connection may be maintained during shipment, storage, insertion, use, and removal of the analyte sensor system 8. Thus, the electromechanically connected components of the analyte sensor system 8 ( e.g., the analyte sensor 10 and the analyte sensor electronics module 12) are "pre-connected" and may be maintained during shipment, storage, insertion, use, and removal of the analyte sensor system 8. Thus, the electromechanically connected components of the analyte sensor system 8 ( e.g., the analyte sensor 10 and the analyte sensor electronics module 12) are "pre-connected" and may be maintained during shipment, storage, insertion, use, and removal of the analyte sensor system 8. Thus, the electromechanically connected components of the analyte sensor system 8 ( e.g., the analyte sensor 10 and the analyte sensor electronics module 12) are "pre-connected" and may be maintained during shipment, storage, insertion, use, and removal of the analyte sensor system 8. Thus, the electromechanically connected components of the analyte sensor system 8 ( ​which may be referred to as a "system". The analyte sensor electronic module 12 can wirelessly communicate (e.g., directly or indirectly) with one or more of display devices 110, 120, 130, and 140. In addition to or instead of display devices 110, 120, 130, and 140, the analyte sensor electronic module 12 can wirelessly communicate (e.g., directly or indirectly) with partner device 136 and / or server system 134. Similarly, in some examples, display devices 110 - 140 can additionally or alternatively wirelessly communicate (e.g., directly or indirectly) with partner device 136 and / or server system 134. The various couplings illustrated in FIG. 1 can be facilitated using wireless access point 138, as also mentioned below. In certain embodiments, the analyte sensor electronic module 12 includes electronic circuitry associated with measuring and processing analyte sensor data or information, including predictive algorithms related to the processing and / or calibration of analyte sensor data / information. The analyte sensor electronic module 12 can be physically / chemically connected to the analyte sensor 10, integrated (non - removably attached) or removably attached to the analyte sensor 10. The analyte sensor electronic module 12 can also be electrically coupled to the analyte sensor 10 such that components can be electromechanically coupled to each other. The analyte sensor electronic module 12 enables the measurement and / or estimation of the level of an analyte within a host / user via the analyte sensor 10 (which can be / include, e.g., a glucose sensor).

[0076] ​​​​​​​​​​​​​It may include hardware, firmware, and / or software. For example, The analyte sensor electronic module 12 includes a potentiostat, a power supply for powering the analyte sensor 10, other components useful for signal processing and data storage, and a remote measurement module for transmitting data from the sensor electronic module to one or more display devices. The electronic device can be fixed to a printed circuit board (PCB) within the analyte sensor system 8, or to a platform, etc., and can take various forms. For example, the electronic device can take the form of an integrated circuit (IC) such as an application specific integrated circuit (ASIC), a microcontroller, a processor, and / or a state machine.

[0077] The sensor electronic module 12 may include a sensor electronic device configured to process sensor information such as sensor data and generate the processed sensor data and displayable sensor information. Examples of systems and methods for processing sensor analyte data are described in more detail in this specification and in U.S. Patent Nos. 7,310,544 and 6,931,327 and U.S. Patent Publication Nos. 2005 / 0043598, 2007 / 0032706, 2007 / 0016381, 2008 / 0033254, 2005 / 0203360 / 0222566, 2007 / 0203966, and 2007 / 0208 245, all of which are incorporated herein by reference in their entirety.

[0078] Referring further to FIG. 1, display devices 110, 120, 130, and / or 14 0 may be configured to display (and / or warn) displayable sensor information that may be transmitted by sensor electronic module 12 (e.g., a customized data package transmitted to the display device based on their respective preferences). Each of display devices 1 10, 120, 130, or 140 may include a display, such as a touchscreen display 112, 122, 132, / or 142, that (respectively) displays sensor information and / or analyte data to the user and / or receives input from the user. For example, a graphical user interface (GUI) may be presented to the user for such purposes. In embodiments, the display device may include a touchscreen display for communicating sensor information to the user of the display device and / or receiving user input, or instead of, or in addition to, a touchscreen display, any other type of user interface, such as a voice user interface. In embodiments, one, some, or all of display devices 11 0, 120, 130, 140 may be configured to display or otherwise communicate sensor information without any additional future processing required for calibration and real-time display of the sensor data when the sensor information is communicated from sensor electronic module 12 (e.g., in the data package transmitted to each respective display device), without any additional future processing. Referring still to FIG. 1, the plurality of display devices 110, 120, 130, 140 depicted in FIG. 1 may receive analyte data (e.g., in embodiments, numerical values and / or arrows) from sensor electronic module 12 and display the analyte data to the user. In some embodiments, one, some, or all of display devices 110, 120, 130, 140 may be configured to display the sensor information received from sensor electronic module 12 (e.g., in the data package transmitted to each respective display device) without any additional future processing required for calibration and real-time display of the sensor data when the sensor information is communicated from sensor electronic module 12 (e.g., in the data package transmitted to each respective display device), without any additional future processing. In some embodiments, one, some, or all of display devices 110, 120, 130, 140 may be configured to display or otherwise communicate sensor information without any additional future processing required for calibration and real-time display of the sensor data when the sensor information is communicated from sensor electronic module 12 (e.g., in the data package transmitted to each respective display device), without any additional future processing.

[0079] The plurality of display devices 110, 120, 130, 140 depicted in FIG. 1 may receive analyte data (e.g., in embodiments, numerical values and / or arrows) from sensor electronic module 12 Specific types of displayable sensor information associated with the data may be specially provided for display and may include a custom display device, such as an analyte display device 110, that is specifically designed. In an embodiment one of a plurality of display devices 110, 120, 130, 140 is based on Android, iOS, or another operating system and is configured to display a graphical representation of continuous sensor data (e.g., including current and / or historical data), such as a smartphone 120 . As further shown in FIG. 1 and as described above, the system 100 may also include a wireless access point (WAP) 138 that is used to couple one or more of the analyte sensor system 8, the plurality of display devices 110, 120, 130, 140, etc., the server system 134 , and the medical device 136 to each other. For example, the WAP 138 may provide WiFi and / or cellular or other wireless connectivity within the system 100. Also, near-field communication (NFC) may be used between the devices of the system 100 to exchange data and perform specialized functions, such as waking up or powering on a device

[0080] , or ending a lower power mode or otherwise changing the state and / or transitioning to an operating mode of the device (e.g., the analyte sensor electronic module 12 and / or the transmitter). The server system 134 may be used to collect analyte data from the analyte sensor system 8 and / or the plurality of display devices and perform, for example, an analysis to generate a universal or individualized model of glucose levels and profiles . The wireless access point (WAP) 138 may be included and may provide, for example, WiFi and / or cellular or other wireless connectivity within the system 100. Also, near-field communication (NFC) may be used between the devices of the system 100 to exchange data and perform specialized functions, such as waking up or powering on a device , or ending a lower power mode or otherwise changing the state and / or transitioning to an operating mode of the device (e.g., the analyte sensor electronic module 12 and / or the transmitter). The server system 134 may be used to collect analyte data from the analyte sensor system 8 and / or the plurality of display devices and perform, for example, an analysis to generate a universal or individualized model of glucose levels and profiles . The wireless access point (WAP) 138 may be included and may provide, for example, WiFi and / or cellular or other wireless connectivity within the system 100. Also, near-field communication (NFC) may be used between the devices of the system 100 to exchange data and perform specialized functions, such as waking up or powering on a device , or ending a lower power mode or otherwise changing the state and / or transitioning to an operating mode of the device (e.g., the analyte sensor electronic module 12 and / or the transmitter). The server system 134 may be used to collect analyte data from the analyte sensor system 8 and / or the plurality of display devices and perform, for example, an analysis to generate a universal or individualized model of glucose levels and profiles . The server system 134 may be used to collect analyte data from the analyte sensor system 8 and / or the plurality of display devices and perform, for example, an analysis to generate a universal or individualized model of glucose levels and profiles . The server system 134 may be used to collect analyte data from the analyte sensor system 8 and / or the plurality of display devices and perform, for example, an analysis to generate a universal or individualized model of glucose levels and profiles . The server system 134 may be used to collect analyte data from the analyte sensor system 8 and / or the plurality of display devices and perform, for example, an analysis to generate a universal or individualized model of glucose levels and profiles . The server system 134 may be used to collect analyte data from the analyte sensor system 8 and / or the plurality of display devices and perform, for example, an analysis to generate a universal or individualized model of glucose levels and profiles Services or feedback that include, for example, individuals or systems that remotely monitor analyte data can be provided. As an overview and example, partner device(s) 136 can communicate wirelessly with analyte sensor system 8, including in the case of authentication of partner device(s) 136 and / or analyte sensor system 8, and also including cases of exchange of analyte data, drug data, other data, and / or control signaling. The partner device 136 can include a passive device in an exemplary embodiment of the present disclosure. An example of the partner device 136 can be an insulin pump for administering insulin to a user in response to and / or in accordance with the user's analyte level(s) measured / approximated using the analyte sensor system 8. For various reasons, such an insulin pump may desirably receive and track glucose values transmitted from the analyte sensor system 8 (see, for example, FIG. 1). One reason for this is to provide the insulin pump with functionality to interrupt / activate / control insulin administration based on the glucose value falling below / above a threshold. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. As an example, various components described below in FIG. 2 can be used, such as, for example, analyte sensor system 308, display device 310, partner device 315, and / or one or more server systems 334. partner device(s) 136 can communicate wirelessly with analyte sensor system 8, including in the case of authentication of partner device(s) 136 and / or analyte sensor system 8, and also including cases of exchange of analyte data, drug data, other data, and / or control signaling. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1.

[0081] Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. Here, referring to FIG. 2, system 200 is depicted. System 200 can be used in connection with implementations of the disclosed system, method, apparatus, and / or device embodiments, including aspects described above in connection with FIG. 1. can provide wireless communication of analyte (e.g., glucose) data among / between each other.

[0082] As shown in FIG. 2, system 200 may include analyte sensor systems 308, one or more display devices 310, and / or one or more partner devices 315. In addition, in the illustrated embodiment, system 200 includes a server system 334, and the server system 334 can include a server 334a coupled to a processor 334c and a storage device 334b. The analyte sensor system 308 can be coupled to the display device 310, the partner device 315, and / or the server system 334 via a communication medium 305. Some details of the processing, collection, exchange, and / or execution of actions (e.g., providing a drug or related instructions) of data by the analyte sensor system 308, the partner device 315, and / or the display device 310, etc. are provided below. The analyte sensor system 308, the display device 310, and / or the partner device 315 may exchange messaging (e.g., control signaling) via the communication medium 305, and the communication medium 305 may be used to distribute analyte data to the display device 310, the partner device 315, and / or the server system 334. As suggested above, the display device 310 may include a variety of electronic computing devices such as, for example, a smartphone, a tablet, a laptop, a wearable device, etc. The display device 310 may also display analyte data and related notifications, etc. and / or perform actions such as the processing, collection, exchange, and / or execution of actions (e.g., providing a drug or related instructions) of data by the analyte sensor system 308, the partner device 315, and / or the display device 310, etc. Some details are provided below. For example, providing a drug or related instructions) are provided below. will be provided.

[0083] The analyte sensor system 308, the display device 310, and / or the partner device 315 may exchange messaging (e.g., control signaling) via the communication medium 305, and the communication medium 305 may also be used to distribute analyte data to the display device 310, the partner device 315, and / or the server system 334. As suggested above, the display device 310 may include a variety of electronic computing devices such as, for example, a smartphone, a tablet, a laptop, a wearable device, etc. The display device 310 may also display analyte data and related notifications, etc. As suggested above, the display device 310 may include a variety of electronic computing devices such as, for example, a smartphone, a tablet, a laptop, a wearable device, etc. The display device 310 may also display analyte data and related notifications, etc. include a variety of electronic computing devices such as, for example, a smartphone, a tablet, It may include an analyte display device 110 that can be customized for glucose transmission. Partner The vice 315 may include medical devices such as insulin pumps or pens, connectable devices such as smart refrigerators or mirrors, key fobs, and other devices.

[0084] In an embodiment, the communication medium 305 may be based on, for example, Bluetooth®, Bluetooth® Low Energy (BLE), ZigBee®, WiFi, IEEE 802.11 protocol, infrared (IR), radio frequency (RF), 2G, 3G, 4G, 5G, etc., and / or one or more wireless communication protocols such as wired protocols and media. Also, considering the present disclosure, it will be understood that the communication medium may, in some cases, be implemented as one or more communication links including separate links between components of the system 200, whether or not such links are explicitly illustrated or referred to in relation to FIG. 2. For example, the analyte sensor system 308 may be coupled to the display device 310 via a first link of the communication medium 305 using BLE, while the display device 310 may be coupled to the server system 334 by a second link of the communication medium 305 using a cellular communication protocol (e.g., 4G LTE / 5G, etc.). In an embodiment, the BLE signal may be temporarily attenuated to minimize data eavesdropping. For example, attenuation of the BLE signal by hardware or firmware design may be temporarily performed during a short period of data exchange (e.g., pairing). etooth(registered trademark) Low Energy(BLE), ZigBee(registered trademark ), WiFi, IEEE802.11 protocol, infrared(IR), radio frequency(RF) , 2G, 3G, 4G, 5G, etc., and / or one or more wireless communication protocols such as wired protocols and media. Also, considering the present disclosure, it will be understood that the communication medium may, in some cases, be implemented as one or more communication links including separate links between components of the system 200, whether or not such links are explicitly illustrated or referred to in relation to FIG. 2. For example, the analyte sensor system 308 may be coupled to the display device 310 via a first link of the communication medium 305 using BLE, while the display device 310 may be coupled to the server system 334 by a second link of the communication medium 305 using a cellular communication protocol (e.g., 4G LTE / 5G, etc.). In an embodiment, the BLE signal may be temporarily attenuated to minimize data eavesdropping. For example, attenuation of the BLE signal by hardware or firmware design may be temporarily performed during a short period of data exchange (e.g., pairing). In some cases, whether or not such links are explicitly illustrated or referred to in relation to FIG. 2 regardless of whether such links are explicitly illustrated or referred to in relation to FIG. 2, it will be understood that the communication medium may be implemented as one or more communication links including separate links between components of the system 200 As an example, the analyte sensor system 308 may be coupled to the display device 310 via a first link of the communication medium 305 using BLE while the display device 310 may be coupled to the server system 334 by a second link of the communication medium 305 using a cellular communication protocol (e.g., 4G LTE / 5G, etc.). In an embodiment, the BLE signal may be temporarily attenuated to minimize data eavesdropping. For example, attenuation of the BLE signal by hardware or firmware design may be temporarily performed during a short period of data exchange (e.g., pairing). while the display device 310 may be coupled to the server system 334 by a second link of the communication medium 305 using a cellular communication protocol (e.g., 4G LTE / 5G, etc.). In an embodiment, the BLE signal may be temporarily attenuated to minimize data eavesdropping. For example, attenuation of the BLE signal by hardware or firmware design may be temporarily performed during a short period of data exchange (e.g., pairing). BLE signals may be temporarily attenuated to minimize data eavesdropping. For example, attenuation of the BLE signal by hardware or firmware design may be temporarily performed during a short period of data exchange (e.g., pairing). For example, attenuation of the BLE signal by hardware or firmware design may be temporarily performed during a short period of data exchange (e.g., pairing). ring) for a short period of time.

[0085] In an embodiment, the elements of system 200 are used to perform the operations of the various processes described herein and / or to execute the various operations and / or features described herein with respect to one or more of the disclosed systems and / or methods. In considering this disclosure, one of ordinary skill in the art will understand that system 200 may include a single or multiple analyte sensor systems 308 , a communication medium 305, and / or a server system 334. As described above, communication medium 305 can be used to connect or communicatively couple analyte sensor system 308, display device 310, partner device 315, and / or server system 334 to each other and / or to a network. Communication medium 305 can be implemented in a variety of forms. For example, communication medium 305 can include one or more of a local area network (LAN), a personal area network (PAN), a wide area network (WAN), an optical fiber network, a power line internet, a hardwired connection (e.g., a bus), DSL , or any other type of network connection or communication coupling such as an internet connection. Communication medium 305 can be implemented using any combination of a router, a cable, a modem, a switch, an optical fiber, a wire, wireless (e.g., microwave / RF, AM, FM link, etc.) .

[0086] Furthermore, communication medium 305 can be Bluetooth (registered trademark), BLE, Wi-Fi, IEEE802.11, 3GPP (registered trademark) standards (e.g., 2G GSM / GPRS / EDGE, 3G UMTS / CDMA20000, or 4G LTE / LTE-A / LTE-U, 5G, or subsequent generations), etc. can be implemented using various wireless standards. Reading this disclosure, one of ordinary skill in the art will recognize other ways to implement the communication medium 305, and will also recognize that the features of this disclosure can be implemented using future, unannounced communication standards that the communication medium 305 may be developed for in the future. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Thus, server 334a can receive, collect, and / or monitor information from partner device 315, such as information regarding the provision of drugs to a user and / or information regarding the operation of one or more partner devices 315. Server 334a can also receive, collect, and / or monitor information regarding the users of analyte sensor system 308, display device 310, and / or partner device 315. In embodiments, server 334a can be adapted to receive such information via communication medium 305. This information may be stored in storage device 334b and may be processed by processor 334c. For example, processor 334c can be an analysis engine that can perform an analysis of the information collected, received, etc. by server 334a via communication medium 305.

[0087] Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315. Referring still to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as inputs responsive to analyte data or drug data, or inputs received in connection with an analyte monitoring application executed on analyte sensor system 308 or display device 310, or a drug delivery application executed on display device 310 or partner device 315.

[0088] In embodiments, server 334a can be adapted to receive such information via communication medium 305. This information may be stored in storage device 334b and may be processed by processor 334c. For example, processor 334c can be an analysis engine that can perform an analysis of the information collected, received, etc. by server 334a via communication medium 305. For example, processor 334c can be an analysis engine that can perform an analysis of the information collected, received, etc. by server 334a via communication medium 305. It may include. In an embodiment, the server 334a, the storage device 334b, and / or the processor 334c can be implemented as a distributed computing network such as a Hadoop (registered trademark) network, or as a relational database, etc. Next, the aforementioned information can be processed by the server 334a so as to be provided to the service for the analyte sensor system 308, the display device 310 , the partner device 315, and / or its user(s). For example, such a service may include diabetes management feedback for the user. For example, such a service may include diabetes management feedback for the user.

[0089] In an embodiment, a database may be implemented in the server system 334, and the communication medium 3 05 can be used to pair a user account with one or more analyte sensor systems 308. For example, based on the individual components of the analyte sensor system 308 or one or more groups of components, or the expected lifespan of the analyte sensor system 308 as a whole, and / or based on the diagnostic feedback received by the analyte sensor system 308, the server system 334 can determine whether a given analyte sensor system 308 or its component or group of components (singular or plural) has reached or passed its useful life. The user can, for example, on the display device 310 and / or via the analyte sensor system 308, from the server system 334, whether its analyte sensor system 308 or component or group of components (singular or plural) has reached or passed its useful life, or will soon or within a given time reach its useful life. from the server system 334, whether its analyte sensor system 308 or component or group of components (singular or plural) has reached or passed its useful life, or will soon or within a given time reach its useful life. will reach its useful life.​ receive an indication, notification, alert, or warning of something. In embodiments, a user may receive an indication, notification, alert, or warning from server system 334 on display device 310 regarding the expected lifespan of analyte sensor system 308 or its component or components' group(s) (singular or plural).

[0090] Server 334a may include, for example, an Internet server, router, desktop or laptop computer, smartphone, tablet, processor, module, etc., and may be implemented in various forms including, for example, the following. It may be implemented in various forms including an integrated circuit or an assembly of integrated circuits, a printed circuit board or an assembly of printed circuit boards, or an individual housing / package / rack, or many of them. In embodiments, server 334a at least partially directs communications that occur via communication medium 305. Such communications may include the delivery of analyte data, drug data, and / or messaging related thereto (e.g., advertisements, authentication, commands, or other messaging). For example, server 334a may process and exchange messages between and / or among analyte sensor system 308, display device 310, and / or partner device 315 regarding, for example, frequency bands, transmission timing, security / encryption, alarms, alerts, notifications, etc. Server 334a may distribute applications to, or otherwise access, information stored in analyte sensor system 308, partner device 315, and / or display device 310. 310, for example. ​​​​​​​​By updating the pre - application and / or reconfiguring system parameters or analysis of the analyte sensor system 308, partner device 315, and / or display device 310 it can be updated. Server 3 34a can communicate information in real - time, periodically, sporadically, or on an event - driven basis, between the analyte sensor system 308, partner device 315, and / or display device 310 and itself. Further, server 334a can implement cloud computing functions for the analyte sensor system 308, partner device 315, and / or display device 310.

[0091] Based on the above description of aspects of the systems and methods of the present disclosure for wireless communication of analyte data, examples of some specific features of the present disclosure are provided herein. Those skilled in the art, upon considering the present disclosure, will understand that these features can be implemented using the aspects of the exemplary configurations and / or combinations of aspects described above, regardless of whether explicit reference to these features has been made.

[0092] Analyte data Referring again to FIG. 1, as described above, in an embodiment, an analyte sensor system 8 is provided for measuring an analyte within a host or user. By way of overview and example, the analyte sensor system 8 performs sensor measurements, generates analyte data (e.g., by calculating values of continuous glucose monitoring data), and transmits such data to remote devices (e.g., display devices 110, 120, 130, 140, partner device 136, and / or a wireless communication (e.g., Bluetooth (registered trademark) and / or other wireless protocols) to the server system 134). It can be implemented as an encapsulated microcontroller.

[0093] The analyte sensor system 8 can include an analyte sensor 10 configured to measure the concentration or level of an analyte within a host, and an analyte sensor electronic module 12 that is normally physically connected to the analyte sensor 10 before the analyte sensor 10 is implanted in a user. In an implementation form, the analyte sensor electronic module 12 includes, for example, an electronic device configured to process a data stream associated with the analyte concentration measured by the analyte sensor 10 to generate sensor information including raw sensor data, converted sensor data, and / or other sensor data. The analyte sensor electronic module 12 can be further configured to generate sensor information customized for each of the display devices 110, 120, 130, 140, the partner device 136, and / or the server system 134. The analyte sensor electronic module 12 can be further configured such that different devices can receive different sensor information, and can be further configured to wirelessly transmit sensor information to such display devices 110, 120, 130, 140, the partner device 136, and / or the server system 134.

[0094] As used herein, the term "analyte" is a broad term and is given its ordinary customary meaning to those skilled in the art (limited to a special meaning or a customized meaning), not fixed), substances or chemical components in body fluids that can be analyzed (e.g., blood, interstitial fluid, cerebrospinal fluid, lymph fluid, or urine), but not limited to these. Analytes include natural substances, artificial substances, metabolites, and / or reaction products. In some embodiments, the analyte to be measured by the sensor head, device, and method is glucose. However, prothrombin carboxypeptidase, acyl carnitine, adenine phosphoribosyltransferase, adenosine deaminase , albumin, α-fetoprotein, amino acid profile (arginine (Krebs cycle), histidine / urocanic acid, homocysteine, phenylalanine / tyrosine, tryptophan), androstenedione, antipyrine, arabinitol enantiomer, arginase, benzoylecgonine (cocaine), biotinidase, biopterin, C-reactive protein, carnitine, carnosinase, CD4, ceruloplasmin, chenodeoxycholic acid, chloroquine, cholesterol, cholinesterase, conjugated 1-β-hydroxy cholic acid, cortisol, creatine kinase, creatine kinase MM isozyme, cyclosporine A, d-penicillamine, de-ethyl chloroquine, dehydroepi androsterone sulfate, DNA (acetylation polymorphism, alcohol dehydrogenase, α1 -antitrypsin, cystic fibrosis, Duchenne / Becker muscular dystrophy, glucose -6-phosphate dehydrogenase, hemoglobin A, hemoglobin S, hemoglobin C , hemoglobin D, hemoglobin E, hemoglobin F, D Punjab, β-thalassemia, hepatitis B virus, HCMV, HIV-1, HTLV-1, Leber hereditary optic neuropathy, M type, and many other substances can also be analytes measured by the sensor head, device, and method of the present invention. type, and many other substances can also be analytes measured by the sensor head, device, and method of the present invention. -6-phosphate dehydrogenase, hemoglobin A, hemoglobin S, hemoglobin C , hemoglobin D, hemoglobin E, hemoglobin F, D Punjab, β-thalassemia, hepatitis B virus, HCMV, HIV-1, HTLV-1, Leber hereditary optic neuropathy, M It should be noted that there seems to be some incomplete or unclear parts in the original text, especially in the last few lines where the description is rather fragmented. The translation is done as accurately as possible based on the available text. CAD, RNA, PKU, Plasmodium malariae, sexual differentiation, 21 - deoxycortisol) , desbutylhalofantrine, dihydropteridine reductase, diphtheria / tetanus antitoxin , erythrocyte arginase, erythrocyte protoporphyrin, esterase D, fatty acid / acyl glycine, free β - human chorionic gonadotropin, free erythrocyte protoporphyrin, free thyroxine (FT4), free tri - iodothyronine (FT3), fumarylacetoacetase, gala ctose / gal - 1 - phosphate, galactose - 1 - phosphate uridyltransferase , gentamicin, glucose - 6 - phosphate dehydrogenase, glutathione, glut athione peroxidase, glycolic acid, glycosylated hemoglobin, halofantri n, hemoglobin variants, hexosaminidase A, human erythrocyte carbonic anhydrase I, 17 - α - hydroxyprogesterone, hypoxanthine phosphoribosyltransferase, immune reactive trypsin, lactate, lead, lipoprotein((a), B / A - 1, β), lysozyme , mefloquine, netilmicin, phenobarbital, phenytoin, phytate / phy stanoic acid, progesterone, prolactin, prolidase, purine nucleoside phosphori lase, kinins, reverse tri - iodothyronine (rT3), selenium, serum pancreatic lipase, shi somysin, somatomedin C, specific antibodies (adenovirus, antinuclear antibody, anti - zeta antibody, arbovirus, OES virus, dengue virus, guinea worm, tapeworm, red dysentery amoeba, enterovirus, Giardia duodenali sa), Helicobacter pylori, hepatitis B virus, herpes virus, HIV - 1, I gE (Atopic diseases), influenza virus, Leishmania donovani, leptospira pyra, measles / mumps / rubella, rabies virus, Mycoplasma pneumoniae, myoglobin, rotavirus filamentous worm, parainfluenza virus, Plasmodium falciparum, poliovirus, Pseudomonas aeruginosa respiratory syncytial virus, Rickettsia (scrub typhus), Schistosoma mansoni, Toxoplasma protozoa, Treponema pallidum (syphilis), Trypanosoma cruzi Trypanosoma gambiense, vesicular stomatitis virus (VSV), Wuchereria bancrofti, yellow fever virus), specific antigens (hepatitis B virus, HIV-1), succinylacetone, sulfadoxine, theophylline, thyrotropin ( TSH), thyroxine (T4), thyroxine-binding globulin, trace elements, transferrin , UDP-galactose-4-epimerase, urea, uroporphyrinogen I synthase -ase, vitamin A, white blood cells, and other analytes including zinc protoporphyrin are contemplated but are not limited thereto. Salts, sugars, proteins, fats, vitamins, and hormones that occur naturally in blood or interstitial fluid can also constitute analytes in certain embodiments Analytes, such as metabolites, hormones, antigens, antibodies, etc., can occur naturally in body fluids Alternatively, analytes, such as contrast agents for imaging diagnostics, radioisotopes, chemical agents , fluorocarbon-based artificial blood, or drugs or pharmaceutical compositions can be introduced into the body, insulin, glucagon, ethanol, cannabis (marijuana, tetrahydrocannabinol , hashish), inhalants (nitrous oxide, amyl nitrite, butyl nitrite, chlorinated hydrocarbons, carbon hydrogen), cocaine (crack cocaine), stimulants (amphetamine, methamphetamine, Ritalin, Cylert, Preludin, Didrex, PreState, Voranil, Sandrex, Plegine), inhibitors (barbiturates, meth cathinone, tranquilizers such as Valium, Librium, Miltown, Ser ax, Equanil, Tranxene), hallucinogens (fenciclovir, lysergic acid , mescaline, peyote, psilocybin), narcotics (heroin, codeine, morphine, ahe n, meperidine, Percocet, Percodan, Tussionex, Fent anyl, Darvon, Talwin, Lomotil), designer drugs (phen tanyl, meperidine, amphetamine, methamphetamine, and fenciclovir analogs such as Ecstasy), anabolic steroids, and nicotine are mentioned, but are not limited thereto. Metabolites of drugs and pharmaceutical compositions are also envisioned as analytes. For example, ascorbic acid, uric acid, dopamine, norepinephrine, 3-meth thoxytetramine (3MT), 3,4-dihydroxyphenylacetic acid (DOPAC), homoba nilic acid (HVA), 5-hydroxytryptamine (5HT), and 5-hydroxyi ndoleacetic acid (FHIAA), etc., neurochemicals and other chemicals produced in the body can also be analyzed as analytes.

[0095] Pre-connected analyte sensor system As suggested above with reference to FIG. 1, in an embodiment, the analyte sensor 10 is, for example, a continuous glucose sensor such as a subcutaneous, transdermal (e.g., transdermal), or intravascular device including. In an embodiment, such a sensor or device is a plurality of intermittent blood samples can be analyzed. The analyte sensor 10 can use any method of analyte measurement, including, for example, glucose measurements including enzymatic, chemical, physical, electrochemical, spectrophotometric, polarization, calorimetric, ion introduction, radiation, immunochemical, etc.

[0096] In embodiments where the analyte sensor 10 is a glucose sensor, the analyte sensor 10 can use any method, including invasive, minimally invasive, and non-invasive detection techniques (e.g., fluorescence monitoring), etc., to provide a data stream indicative of the glucose concentration within the host. The data stream is typically a raw data signal and can be converted into a calibrated and / or filtered data stream for use by a user, such as a patient or caregiver (e.g., parent, relative, guardian, teacher, physician, nurse, or any other individual interested in the health of the host), etc., to provide useful glucose values.

[0097] A glucose sensor can be any device capable of measuring the concentration of glucose obtainable. According to one exemplary embodiment described below, an implantable glucose sensor can be used. However, it should be understood that the devices and methods described herein can be applied to any device capable of detecting the concentration of an analyte, such as glucose, and providing an output signal (e.g., in the form of analyte data) representative of the concentration of the analyte, also glucose.

[0098] In an embodiment, the analyte sensor 10 is an implant as described with reference to U.S. Patent No. 6,001,067 and U.S. Patent Publication No. US2005 / 0027463-A1. ​​​​​​It is an implantable glucose sensor. In an embodiment, the analyte sensor 10 is a transcutaneous glucose sensor as described with reference to U.S. Patent Publication No. US2006 / 0020187-A1. In an embodiment, the analyte sensor 10 is a transcutaneous glucose sensor as described with reference to U.S. Patent Publication No. US2007 / 0027385-A1, simultaneously filed on October 4, 2006, U.S. Patent Publication No. US2008 / 0119703-A1, filed on March 26, 2007, U.S. Patent Publication No. US2008 / 0108942-A1, and U.S. Patent Application No. US2007 / 0197890-A1 filed on February 14, 2007, and is configured to be implanted in a host blood vessel or outside the body. In an embodiment, the continuous glucose sensor includes, for example, a transcutaneous sensor as described in U.S. Patent No. 6,565,509 to Say et al. In an embodiment, the sensor 10 includes, for example, a subcutaneous sensor as described with reference to U.S. Patent No. 6,579,690 to Bonnecaze et al., or a continuous glucose sensor including a subcutaneous sensor as described with reference to U.S. Patent No. 6,484,046 to Say et al. In an embodiment, the continuous glucose sensor includes, for example, a refillable subcutaneous sensor as described with reference to U.S. Patent No. 6,512,939 to Colvin et al. The continuous glucose sensor may include, for example, an intravascular sensor as described with reference to U.S. Patent No. 6,477,395 to Schulman et al. The continuous glucose sensor may include, for example, an intravascular sensor as described with reference to U.S. Patent No. 6,424,847 to Mastrototaro et al.

[0099] Before the system operates, the analyte sensor electronic module 12 is typically maintained in a lower power mode to conserve or manage battery capacity. The analyte sensor electronic module 12 should generally be actuated to start collecting analyte data in an active power state. For example, it may be preferable not to operate the analyte sensor electronic module 12 until before and after the time when the analyte sensor 10 is implanted in the host. This can help maintain more accurate sensor calibration, reduce power consumption, and / or generally increase analyte measurement accuracy, etc. In some embodiments, the operation of the analyte sensor electronic module 12 and / or specific circuitry of the analyte sensor electronic module 12 can be performed at least mainly before the implantation of the analyte sensor 10 (e.g., 5 minutes, 1 minute, 30 seconds, 10 seconds, 1 second, or less than 1 second before implantation, etc.). In some embodiments, the operation of the analyte sensor electronic module 12 can be performed at least mainly during or substantially during implantation (e.g., at least partially while the analyte sensor 10 is moving to the deployment position). In some embodiments, the operation of the analyte sensor electronic module 12 can be performed at least mainly after the implantation of the analyte sensor 10 (e.g., less than 1 second, 1 second, 5 seconds, 30 seconds, 1 minute, 3 minutes, 5 minutes, 10 minutes, more than 10 minutes, etc.). In embodiments, it is preferable for the analyte sensor electronic module 12 to end the lower power state at or immediately before the time before and after the analyte sensor 10 is implanted. This may enable more accurate recording of the implantation time.

[0100] In a system that is not pre-connected, the analyte sensor 10 and the analyte sensor electronic module 12 are typically mechanically and electrically connected only after the analyte sensor 10 has been implanted in the user. When the analyte sensor electronic module 12 is already coupled to the implanted analyte sensor 10, the electrodes of the analyte sensor electronic module 12 are typically monitored to detect signals related to the analyte. The analyte sensor system 8 can then be actuated in response to the binding and detection of a particular level or characteristic of the analyte within the user. However, in a pre-connected analyte sensor system 8, the analyte sensor 10 is electromechanically coupled to the analyte sensor electronic module 12 before the analyte sensor system 8 is delivered to the user, and thus, at the time of sensor implantation, the analyte sensor electronic module 12 is already coupled to the analyte sensor 10. As suggested above, this pre-binding or pre-connection can lead to false wake-ups or activation from a lower power state due to signals generated by the analyte sensor system 8, for example, in situations such as high humidity, static electricity, leakage, or noise, prior to sensor implantation. Also, in order to improve the accuracy in converting sensor signals using a sensor processing algorithm, it may be preferable for the analyte sensor 10 not to be voltage biased by the analyte sensor electronic module 12 prior to implantation. Operations that can cause changes in the characteristics of the analyte sensor 10 should generally be minimized prior to implantation. Thus, it may be preferable to avoid or at least reduce the occurrence of voltage-biased analyte sensors 10 prior to implantation. For relatively long periods ( e.g., in high humidity, static electricity, leakage, or noise situations) before sensor implantation, the analyte sensor system 8-generated signals can cause false wake-ups or activation from a lower power state. Also, in order to improve the accuracy in converting sensor signals using a sensor processing algorithm, it may be preferable for the analyte sensor 10 not to be voltage biased by the analyte sensor electronic module 12 prior to implantation.

[0101] Operations that can cause changes in the characteristics of the analyte sensor 10 should generally be minimized prior to implantation. Thus, it may be preferable to avoid or at least reduce the occurrence of voltage-biased analyte sensors 10 prior to implantation. For relatively long periods ( ​​​​​​​​For example, by applying a voltage bias to the analyte sensor 10 during storage, the service life of the analyte sensor 10 can be shorter than the intended service life following implantation. This can be , for example, due to the consumption of a reference volume or an enzyme volume that may be included on the analyte sensor 10 . Further, the analyte processing algorithms that can be used by the analyte sensor system 8 can depend on the characterized performance values of the analyte sensor 10. These characterized performance values include a baseline signal, analyte sensitivity, signal drift, lot performance metrics , curve fitting variables, tabular values, calibration codes, and / or additional factors that can be used as part of a signal processing algorithm in connection with determining an analyte value . Thus, in some cases, particularly in the case of analyte sensors 10 that are factory calibrated, it can be important to make a relatively accurate estimate of the performance parameters and / or characteristics of the analyte sensor 10 at the time of implantation into the user in order to enable the accurate generation of analyte values . Applying a voltage bias across the analyte sensor 10 for a significant period (e.g., during shelf life ) can cause a deviation from one or more predetermined performance metrics. This can tend to reduce the accuracy of the analyte value determined using a sensor processing algorithm that converts one or more measured analyte sensor 10 signals into an analyte value after implantation of the analyte sensor 10. Further, a deviation from the calibrated state of the analyte sensor 10 during storage can cause the algorithm to report a less accurate or inaccurate analyte value . . . . . . .

[0102] . Further, the circuitry and / or other components that control the operation of the analyte sensor system 8 The amount of power (e.g., mW) used by the transponder (e.g., within the analyte sensor electronic module) should generally be minimized, reduced, and / or taken into account in relation to making system-level performance trade-offs, if possible. For measurements generated by the analyte sensor 1 0 or other circuits and components, generally, prior to operation of the analyte sensor system 8, efforts should be taken to minimize, reduce, and / or control the power usage. The power budget can be at least somewhat limited by the battery capacity of the analyte sensor system 8. Thus, the analyte sensor system 8 may primarily be in a lower power or mostly non-operating state prior to operation, and the techniques used to control system operation and / or exit a lower power state may consume a small portion of the available power. In embodiments, lower power consumption is achieved, for example, by selecting a reduced or minimum executable polling or sampling frequency for system startup events and / or the power usage and detectability of triggers. In some cases, the sampling or polling frequency used to monitor an operation event / trigger / characteristic may vary based on the type of detection method being used (e.g., capacitive measurement vs. accelerometer input as described below). In relation to reducing power consumption, a lower power state machine that performs measurements and logic functions to trigger a system wake-up without powering on the main system processor may be used. For example, reduced and / or variable, adaptable, programmable, and / or configurable

[0103] In embodiments, lower power consumption is achieved, for example, by selecting a reduced or minimum executable polling or sampling frequency for system startup events and / or the power usage and detectability of triggers. In some cases, the sampling or polling frequency used to monitor an operation event / trigger / characteristic may vary based on the type of detection method being used (e.g., capacitive measurement vs. accelerometer input as described below). In relation to reducing power consumption, a lower power state machine that performs measurements and logic functions to trigger a system wake-up without powering on the main system processor may be used. For example, reduced and / or variable, adaptable, programmable, and / or configurable In some cases, the sampling or polling frequency used to monitor an operation event / trigger / characteristic may vary based on the type of detection method being used (e.g., capacitive measurement vs. accelerometer input as described below). In relation to reducing power consumption, a lower power state machine that performs measurements and logic functions to trigger a system wake-up without powering on the main system processor may be used. For example, reduced and / or variable, adaptable, programmable, and / or configurable capacitive measurement vs. accelerometer input) may vary based on the type of detection method being used (e.g., as described below). In relation to reducing power consumption, a lower power state machine that performs measurements and logic functions to trigger a system wake-up without powering on the main system processor may be used. For example, reduced and / or variable, adaptable, programmable, and / or configurable In relation to reducing power consumption, a lower power state machine that performs measurements and logic functions to trigger a system wake-up without powering on the main system power states may be used.​ By using a polling or sampling frequency, a lower power state can be effectively maintained. In some cases, the use of a low power state machine can facilitate this lower power state. Despite periodic polling / sampling that may be performed in connection with detecting the operating events of the analyte sensor system 8, a lower power state in which power consumption can be controlled / reduced is generally maintained in this manner.

[0104] In embodiments, the analyte sensor system 8 is more robust against false wake-ups, and if a false wake-up is detected, the system can return to a lower power state. For example, at any point in time, if the analyte sensor system 8 detects that the analyte sensor 10 generates a signal that does not meet a threshold or one or more characteristics indicating a wake-up event, the analyte sensor system 8 can return to a lower power state or remain in a lower power state. As an example, in such a lower power state, there may be no data transmission or analyte measurement by the analyte sensor electronics module 12. In many cases, the lower power state and the active state can be implemented mainly in firmware, although some wake-up circuits may have hardware integration to enable a more robust operating detection mechanism (e.g.,

[0105] such as discharging a capacitor as described herein). Thus, embodiments of the present disclosure include a number of techniquesInvolves using components / circuits. By way of example, such a change may be accompanied by the analytical sensor system 8 being activated and exiting a lower power state and / or being moved to a more active state. This may occur in response to a condition indicating that the analytical sensor 10 is embedded in the user. In one example, the analytical sensor system 8 can detect an analyte using the analytical sensor 10 and a potentiostat or other measurement device that applies a voltage bias to one or more electrodes of the analytical sensor 10 and measures the resulting quantity of the flowing current. This current and / or associated signals may be referred to herein as primary signals.

[0106] In addition, by way of example, there may be a characteristic signal profile that can be measured when the analytical sensor 10 is embedded in the host tissue. Such a characteristic signal profile may result from changes such as membrane hydration and / or changes resulting from analyte and / or ion concentration, and may result from changes in the analytical sensor 10 when the analytical sensor 10 is first exposed to the tissue environment. Such a characteristic signal profile may be referred to herein as a secondary signal. In an embodiment, the secondary signal may include or be accompanied by the use of capacitance,

[0107] The signal characteristics of the primary signal measured using the analytical sensor 10 (e.g., voltage or current) together with in vivo and / or factory calibration information of the analytical sensor 10 are implemented, for example, using the analytical sensor It can be used by the analyte processing algorithm to be performed. The signal characteristics of the primary signal can change over time. Examples of signal profiles of analyte values (which can be measured, for example, in mg / dL) or other measurements (such as voltage, current, digital "count", etc.) performed using one or more electrodes of the analyte sensor 10 include the following: signal gradient, signal threshold, integration over time, slope, balance, range, or other characteristics that can be used to specifically identify the signal. Such signal profiles / characteristics can be defined in advance in the analyte sensor system 8. 0

[0108] In the pre-connected analyte sensor system 8, by using a number of the techniques mentioned above and other means such as operations / state changes, the embedding of the analyte sensor 10 into the user can be detected more accurately, which in turn has many advantages. For example, by accurately detecting or estimating the embedding time of the analyte sensor 10, the system calibrated at the factory can be made better possible. As an example, for example, (referring to FIG. 5 as an example) the signal processing algorithm implemented using the processor 535 of the analyte sensor system 308 can use one or more techniques in the conversion of the analyte sensor signal to the estimated analyte value. During various periods of the life cycle of the analyte sensor 10 (such as less than 1 hour after embedding, less than 4 hours after embedding, more than 4 hours after embedding, etc.), these conversion techniques can provide different levels of accuracy regarding the conversion regime. In an embodiment, some of these techniques may depend on a predetermined signal profile that is time-dependent. Therefore, recording and / or estimating the more accurate embedding time of the analyte sensor 10 is signal processing. ​​​​​​​​​​​​​​​ selecting a reasoning algorithm and coping with variations in processing techniques that can be performed as a function of time can be beneficial. Therefore, an analyte sensing system 8 using such techniques / means can have improved overall accuracy and improved performance when the analyte sensor 10 is embedded (e.g., including errors that can be induced by not accurately evaluating / detecting the time when the analyte sensor 10 is embedded, since it may affect the performance during embedding). For example, due to the slope of the sensitivity of the analyte sensor 10 following embedding, or due to background signal changes that can occur following the embedding of the analyte sensor 10, inaccuracies can be introduced.

[0109] Accurate detection of the embedding time can also enable the analyte sensing system 8 to start up more quickly from the perspective of providing analyte information to the user. For example, a more accurate embedding time can be useful for the analyte calculation algorithm implemented in the analyte sensing system 8 to determine an appropriate time point (e.g., the reliability between the signal and the analyte conversion) to start displaying analyte information to the user. The slope of the signal change related to the analyte within the first period (e.g., 2 hours, etc.) after the embedding of the analyte sensor 10 can cause embedding timing errors to result in inappropriate predictions for the signal response and the analyte signal. By recognizing the time point of the characteristic signal attenuation curve, the analyte sensing system 8 and / or a device operating in conjunction with the analyte sensing system 8 can be relatively faster (e.g., 2 hours, 1 hour, 30 minutes, 15 minutes, or shorter) than when the embedding time of the analyte sensor 10 is not accurately determined. ​​​​​​​​​​​​​​​​within a certain time) and can display or provide analyte information (e.g., referring to FIG. 1 as an example, on display devices 110, 120, 130, 140, to server system 134, and / or to partner device(s) 136). Referring to , within a relatively short time (e.g., within 10 to 15 minutes) after the analyte sensor 10 is inserted / embedded, analyte information can be displayed or provided (e.g., referring to FIG. 1 as an example, on display devices 110, 120, 130, 140, to server system 134, and / or to partner device(s) 136). In addition, accurate detection of the embedding time of the analyte sensor 10 can assist in preventing the reuse of the analyte sensor 10. Detection of the sensor embedding time by the electronic module 12 can enable a higher reliability metric compared to relying on the user to provide a notification of the insertion / embedding time. For example, the disconnection and / or embedding characteristics can distinguish a newly inserted analyte sensor 10 from an attempt by the user to restart an expired analyte sensor 10.

[0110] In addition, accurate detection of the embedding time of the analyte sensor 10 can assist in preventing the reuse of the analyte sensor 10. Detection of the sensor embedding time by the electronic module 12 can enable a higher reliability metric compared to relying on the user to provide a notification of the insertion / embedding time. For example, the disconnection and / or embedding characteristics can distinguish a newly inserted analyte sensor 10 from an attempt by the user to restart an expired analyte sensor 10. In addition, accurate detection of the embedding time of the analyte sensor 10 can assist in preventing the reuse of the analyte sensor 10. Detection of the sensor embedding time by the electronic module 12 can enable a higher reliability metric compared to relying on the user to provide a notification of the insertion / embedding time. For example, the disconnection and / or embedding characteristics can distinguish a newly inserted analyte sensor 10 from an attempt by the user to restart an expired analyte sensor 10. In addition, accurate detection of the embedding time of the analyte sensor 10 can assist in preventing the reuse of the analyte sensor 10. Detection of the sensor embedding time by the electronic module 12 can enable a higher reliability metric compared to relying on the user to provide a notification of the insertion / embedding time. For example, the disconnection and / or embedding characteristics can distinguish a newly inserted analyte sensor 10 from an attempt by the user to restart an expired analyte sensor 10. In addition, accurate detection of the embedding time of the analyte sensor 10 can assist in preventing the reuse of the analyte sensor 10. Detection of the sensor embedding time by the electronic module 12 can enable a higher reliability metric compared to relying on the user to provide a notification of the insertion / embedding time. For example, the disconnection and / or embedding characteristics can distinguish a newly inserted analyte sensor 10 from an attempt by the user to restart an expired analyte sensor 10. In addition, accurate detection of the embedding time of the analyte sensor 10 can assist in preventing the reuse of the analyte sensor 10. Detection of the sensor embedding time by the electronic module 12 can enable a higher reliability metric compared to relying on the user to provide a notification of the insertion / embedding time. For example, the disconnection and / or embedding characteristics can distinguish a newly inserted analyte sensor 10 from an attempt by the user to restart an expired analyte sensor 10. In addition, accurate detection of the embedding time of the analyte sensor 10 can assist in preventing the reuse of the analyte sensor 10. Detection of the sensor embedding time by the electronic module 12 can enable a higher reliability metric compared to relying on the user to provide a notification of the insertion / embedding time. For example, the disconnection and / or embedding characteristics can distinguish a newly inserted analyte sensor 10 from an attempt by the user to restart an expired analyte sensor 10.

[0111] As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). As an additional example, accurate detection / estimation of the embedding time of the analyte sensor 10 can enable a faster connection establishment between the analyte sensor electronic module 12 and a device connectable to the analyte sensor electronic module 12 (e.g., referring to FIG. 1). With more accurate detection and / or estimation of the embedding time of the analyte sensor 10, the analyte sensor system 8 can establish a plurality of devices and be placed in a state of communicating with multiple devices based on being approximately at the embedding time or at the embedding time point. For example, the analyte sensor system 8 can enable a wireless connection to the analyte sensor system 8 by display devices (e.g., referring to FIG. 1 as an example, display devices 110, 120, 130, 140, partner device(s) 136, etc.) within a relatively short time of embedding (e.g., within 10 to 15 minutes). ) may be able to transition to a paired state among them. Also, the Using a more accurate detection of the implantation time to trigger an alternative connection profile and facilitate a faster connection such as pairing, encryption, advertisement characteristics, etc. That is, for example, using a more definitive wake-up event, a more proactive connection model such as between the analyte sensor system 8 and a device connectable to the analyte sensor system 8 can be facilitated (e.g., transmitting advertisement packets at a faster speed, etc.). This may enable a faster connection establishment and also provide the user with near real-time feedback that the analyte sensor system 8 is receiving a signal and is connected to a display device. Another example of an advantage associated with an accurate estimation of the implantation time of the analyte sensor 10, which may be made possible by a more robust wake-up technique for the analyte sensor 8, is improved error detection. By knowing the predicted profile and monitoring the signal measured using the analyte sensor 10 since implantation, a deviation from the expected characteristics of the implantation in the signal profile can be recognized. This can be made possible by the knowledge of the implantation time of the analyte sensor 10 and the ability to analyze the analyte signal at the time of implantation (e.g., the signal associated with the implantation is less likely to be missed because the analyte sensor system 8 is in a lower power state). The ability to recognize such a deviation may trigger an error in the safety or accuracy of the system, which may be dangerous for the user of the analyte sensor system 8. For example, physically damaged (e.g., membrane rupture,

[0112] analyte sensor 10, which may be made possible by a more robust wake-up technique for the analyte sensor 8, is improved error detection. By knowing the predicted profile and monitoring the signal measured using the analyte sensor 10 since implantation, a deviation from the expected characteristics of the implantation in the signal profile can be recognized. This can be made possible by the knowledge of the implantation time of the analyte sensor 10 and the ability to analyze the analyte signal at the time of implantation (e.g., the signal associated with the implantation is less likely to be missed because the analyte sensor system 8 is in a lower power state). The ability to recognize such a deviation may trigger an error in the safety or accuracy of the system, which may be dangerous for the user of the analyte sensor system 8. For example, physically damaged (e.g., membrane rupture, the knowledge of the implantation time of the analyte sensor 10 and the ability to analyze the analyte signal at the time of implantation (e.g., the signal associated with the implantation is less likely to be missed because the analyte sensor system 8 is in a lower power state). The ability to recognize such a deviation may trigger an error in the safety or accuracy of the system, which may be dangerous for the user of the analyte sensor system 8. For example, physically damaged (e.g., membrane rupture, broken, etc.).​​​​​​​​ After implantation, the analyte sensor 10 (e.g., due to breakage, manufacturing errors, etc.) may have different characteristic signals. .

[0113] Yet another example of an advantage associated with the accurate estimation of the implantation time of the analyte sensor 10 is the faster wake-up time of the analyte sensor system 8, which may also enable an improvement in error detection capability. The risk of user variability in the implantation time of the analyte sensor 10 can be reduced by using the pre-connected analyte sensor system 8 and by automatically or semi-automatically detecting the implantation time of the analyte sensor 10. An analyte sensor 10 inserted into an incorrect tissue location (e.g., subcutaneously or into muscle / fascia other than the desired tissue layer) may have characteristic signals different from those expected following insertion. The faster wake-up time enables such problems to be detected more quickly following implantation, and the overall error detection performance associated with the analyte sensor system 8 can be improved.

[0114] FIG. 3A shows a perspective view of a skin sensor assembly 360 that can be used in connection with a pre-connected analyte sensor system 8 according to some embodiments. For example, the skin analyte sensor assembly 360 can include the analyte sensor system 8, as referred to by way of example in FIG. 1. The skin sensor assembly 360 can include an outer housing that includes a first upper portion 392 and a second lower portion 394. In an embodiment, the outer housing can include a clam shell design. The skin sensor assembly 360 can include components similar to the analyte sensor electronics module 140 described above in connection with FIG. 1, e.g., a potentiostat, an analyte sensor A power supply for supplying power to 10, a signal processing component, a data storage component , and a communication module for one-way or two-way data communication (e.g., a telemetry module ule), a printed circuit board (PCB), an integrated circuit (IC), an application-specific integrated circuit (ASI C), a microcontroller, and / or a processor).

[0115] As shown in FIG. 3A, the outer housing may generally feature an elliptical shape. The outer housing is disposed substantially through the central portion of the outer housing and further includes an opening 396 that is adapted to pass through the sensor 3 38 and the bottom of the on-skin sensor assembly 360 and for needle insertion. In an embodiment, the opening 396 may be a channel or an elongated slot . The on-skin sensor assembly 360 may further include an adhesive patch 326 configured to fix the on-skin sensor assembly 360 to the skin of the host . In an embodiment, the adhesive patch 326 may include a pressure-sensitive adhesive suitable for skin adhesion, e.g., a pressure-sensitive adhesive (e.g., acrylic-based, rubber-based, or other suitable type) bonded to a carrier substrate suitable for skin attachment (e.g., span lace polyester, polyurethane film, or other suitable type), but any suitable type of adhesive is also contemplated. As shown, the adhesive patch 396 features an opening 398 that is positionally aligned with the opening 396 such that the sensor 338 can pass through the bottom of the on-skin sensor assembly 360 and the adhesive patch 396 . . . . .

[0116] FIG. 3B shows a bottom perspective view of the on-skin sensor assembly 360 of FIG. 3A. FIG. 3B shows an opening 396 disposed substantially at the central portion of the bottom of the on-skin sensor assembly 360 and an opening ... Further shown are the mouth portion 398, both being adapted for the sensor 338 and needle insertion.

[0117] FIG. 4 shows a cross-sectional view of the skin sensor assembly 360 of FIGS. 3A and 3B. FIG. 4 shows the first upper portion 392 and the second lower portion 394 of the outer housing, the adhesive patch 326 the opening 396 in the central portion of the skin sensor assembly 360, the opening 398 in the central portion of the adhesive patch 326, and the sensor 338 passing through the opening 396. With reference to FIG. 3A The electronic device unit described above in connection with may further include a circuit board 404 and a battery 402 configured to supply power to at least the circuit board 404.

[0118] Referring now to FIG. 5, a more detailed functional block diagram of the analyte sensor system 308 ( for example, as discussed above in connection with FIGS. 1 and 2) is provided. As shown in FIG. 5 the analyte sensor system 308 may include an analyte sensor 530 (e.g., which may also be designated by reference numeral 10 in FIG. 1) coupled to an analyte sensor measurement circuit 525 for processing and managing sensor data. The sensor measurement circuit 525 may be coupled to a processor / microprocessor 5 35 (which may be part of item 12 in FIG. 1, for example). In some embodiments the processor 535 may perform some or all of the functions of the sensor measurement circuit 525 to acquire and process sensor measurements from the sensor 530.

[0119] The processor 535 transmits sensor and other data and receives requests and commands as well as other signals from external devices such as the display device 310 (see FIG. 2 by way of example). ​​​​For purposes of belief, it may be further coupled to a wireless unit or transceiver 510 (e.g., which may be part of item 12 of FIG. 1). The display device 310 may be used to display or otherwise provide sensor data (or analyte data) or data derived therefrom to the user, server system 334, and / or partner device 315. The partner device 315 may utilize sensor data or derivative data derived from the sensor data in the administration of a drug (e.g., insulin) and / or diabetes management guidance to the user. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. The analyte sensor system 308 may also include an activation detection circuit 520. The activation detection circuit 520 may optionally operate in conjunction with an activation detection component 545. The activation detection component 545 may be integrated into the analyte sensor system 308, may be a component attachable to the analyte sensor system 308, and / or may be external to the analyte sensor system 308. Examples of the activation detection circuit 520 include (1) a measurement circuit that measures electrical characteristics associated with the analyte sensor 10, such as capacitance or impedance, (2) a detection circuit that may use, for example, capacitive sensing, inductive sensing, magnetic detection, acoustic detection, etc. to the user, server system 334, and / or partner device 315. The partner device 315 may utilize sensor data or derivative data derived from the sensor data in the administration of a drug (e.g., insulin) and / or diabetes management guidance to the user. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. to the user, server system 334, and / or partner device 315. The partner device 315 may utilize sensor data or derivative data derived from the sensor data in the administration of a drug (e.g., insulin) and / or diabetes management guidance to the user. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. The partner device 315 may utilize sensor data or derivative data derived from the sensor data in the administration of a drug (e.g., insulin) and / or diabetes management guidance to the user. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. The partner device 315 may utilize sensor data or derivative data derived from the sensor data in the administration of a drug (e.g., insulin) and / or diabetes management guidance to the user. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. The partner device 315 may utilize sensor data or derivative data derived from the sensor data in the administration of a drug (e.g., insulin) and / or diabetes management guidance to the user. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. As used herein, the terms “wireless unit” and “transceiver” may be used interchangeably and generally refer to a device capable of wirelessly transmitting and receiving data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data. The analyte sensor system 308 may further include a storage device 515 (e.g., which may be part of item 12 of FIG. 1) and a real-time clock (RTC) 540 (e.g., which may be part of item 12 of FIG. 1) for storing and tracking sensor data and other data.

[0120] The analyte sensor system 308 may also include an activation detection circuit 520. The activation detection circuit 520 may optionally operate in conjunction with an activation detection component 545. The activation detection component 545 may be integrated into the analyte sensor system 308, may be a component attachable to the analyte sensor system 308, and / or may be external to the analyte sensor system 308. The activation detection circuit 520 may optionally operate in conjunction with an activation detection component 545. The activation detection component 545 may be integrated into the analyte sensor system 308, may be a component attachable to the analyte sensor system 308, and / or may be external to the analyte sensor system 308. The activation detection component 545 may be integrated into the analyte sensor system 308, may be a component attachable to the analyte sensor system 308, and / or may be external to the analyte sensor system 308. The activation detection component 545 may be integrated into the analyte sensor system 308, may be a component attachable to the analyte sensor system 308, and / or may be external to the analyte sensor system 308. The activation detection component 545 may be integrated into the analyte sensor system 308, may be a component attachable to the analyte sensor system 308, and / or may be external to the analyte sensor system 308. Examples of the activation detection circuit 520 include (1) a measurement circuit that measures electrical characteristics associated with the analyte sensor 10, such as capacitance or impedance, (2) a detection circuit that may use, for example, capacitive sensing, inductive sensing, magnetic detection, acoustic detection, etc. a detection circuit that may use, for example, capacitive sensing, inductive sensing, magnetic detection, acoustic detection, etc. Proximity detection circuit, (3) temperature measurement circuit, (4) accelerometer circuit, (5) NFC / RFID wireless and / or antenna circuit, (6) barometric pressure detection circuit, (7) audio circuit, (8) optical detection circuit, (9) conductivity measurement circuit, (10) switch detection circuit, (11) strain detection circuit, etc. It may include one or more of these. The operation detection circuit 520 and / or the operation detection component 545 also triggers events / conditions and / or measurements of the analysis value / characteristic / profile to detect operation events / triggers and to enable the operation of the analyte sensor system 8 in other ways as described herein. It may use or include logic circuitry adapted to execute stored instructions or computer code to perform the functions. Additional details regarding the operation detection circuit 520 and the operation detection component 5 45 are further considered elsewhere in this specification.

[0121] The analyte sensor system 308 of an exemplary implementation collects analyte data using the sensor 530 and transmits the analyte data or a derivative of the analyte data to the display device 310, the partner device 315, and / or the server system 334. Data points regarding the analyte value can be collected and transmitted over the lifetime of the sensor 530. New measurement values and / or related information can be transmitted at a frequency sufficient for a remote device / individual to adequately monitor the analyte (e.g., glucose) level.

[0122] Many details regarding the processing, collection, and exchange of data by the analyte sensor system 308, the partner device 315, and / or the display device 310, etc. are described herein. It should be understood that it is provided elsewhere. Considering the present disclosure, the analyte sensor System 308 may include some similar components described with respect to FIG. 1 or FIG. 2 for at least some embodiments herein and it will be understood that. Thus, even if the details and use of such similar components are not explicitly described herein with reference to FIG. 5, they may be understood with respect to the analyte sensor system 308 .

[0123] End of Low Power State As discussed above, embodiments of the present disclosure relate to the timing for operating the analyte sensor system 308 or causing it to exit a lower power mode, particularly when the analyte sensor system 308 is a pre-connected system. For example, in such a pre-connected system, the analyte sensor 10 can be mechanically and electrically coupled to the analyte sensor electronic module 12 before the analyte sensor 10 is embedded in the host . There are several different periods during which the analyte sensor system 308 can exit a lower power mode, and each period typically has an associated trade-off . One period during which the analyte sensor system 308 can exit a lower power state is when the user opens the package enclosing the analyte sensor system 308 or removes the analyte sensor system 308 from such a package. For example, using the switches, magnets, or other means described herein, in response to the opening of the shipping box or sterilization pack for the analyte sensor system 308, to the analyte sensor system 308

[0124] In response to the removal of the cap / lid of the system and / or the foil / tyre of the system Responding to the peeling of the backpackaging to cause the device to exit a lower power state. However, by exiting the lower power state during this period, the analyte It is likely that the sensor 10 will not be inserted into the user immediately prior to insertion, and therefore the analyte sensor This potentially increases the power usage requirements of the sensor system 308. For example, If the stem 308 is typically delivered to the user in a single package (e.g., a four-pack), In this case, it is likely that only one of the analyte sensor systems 308 will be used in the near future. In any case, all delivered analyte sensor systems 308 will operate in this scenario. In another example, a user may remove the packaging lid of the analyte sensor system 308. After the analyte sensor 10 is disconnected, thus triggering the analyte sensor 10 to be biased, The analyte sensor 10 is biased to zero or other secondary verification means are used. It is possible to delay embedding of the , and thus to avoid such secondary verification measures (e.g. , NFC, accelerometer, impedance measurement, etc., as described in detail herein. ) resulting from applying bias. The resulting calibration drift can potentially reduce the accuracy of the analyte sensor 10 .

[0125] Another exemplary time period during which the analyte sensor system 308 may exit the lower power state is minutes. When the deposition sensor system 308 is in the applicator but has not yet been deployed. Exemplary techniques that may be used to exit a lower power state during this period are described further below. As will be discussed in more detail below, it includes mechanical means (e.g., a bridge, etc.) and electrical or other non-mechanical means (e.g., NFC, magnetic, sonic detection, etc.). In certain situations, this period may be preferred because it may be easier to detect an activation event. For example, during this period, a normally detectable event that can occur (such as the analyte sensor system 308 changing its position relative to the applicator) can occur over a longer period compared to a detectable event that may be associated with, for example, the deployment of the analyte sensor system 308. Therefore, this period may be preferred. This period is usually closer in time to the implantation of the analyte sensor 10, so it may be preferred for detecting an indicator related to activation. Thus, it helps to reduce an incorrect wake-up created by the user, such as when the user unpacks the analyte sensor system 308 but then chooses not to implant the analyte sensor 10. Therefore, an event that can occur at the applicator of the analyte sensor system 308 can serve as a more effective marker for estimating the implantation time and / or causing the analyte sensor system 308 to be activated or to exit a lower power state. Another period during which the analyte sensor system 308 can be caused to exit a lower power state is during the deployment of the analyte sensor system 308 (e.g., the movement of the analyte sensor 10 from a proximal position to a distal position within the host tissue). Here too, either electrical means or electromechanical means, or both, can be used to detect the deployment of the analyte sensor system 308.

[0126] Another period during which the analyte sensor system 308 can be caused to exit a lower power state is during the deployment of the analyte sensor system 308 (e.g., the movement of the analyte sensor 10 from a proximal position to a distal position within the host tissue). Here too, either electrical means or electromechanical means, or both, can be used to detect the deployment of the analyte sensor system 308. near the host tissue from a proximal position to a distal position). Here too, either electrical means or electromechanical means, or both, can be used to detect the deployment of the analyte sensor system 308. It can trigger the start. However, when using events related to deployment for the purpose of operation, one Two potential problems are that the deployment usually occurs over a shorter period of time for operation-related indicators, for example, in association with an applicator (as described above), so that signals or events related to the applicator are more likely to be overlooked or difficult to detect. Another period that can be used to cause the analyte sensor system 308 to exit the lower power state can be after the embedding of the analyte sensor 10. To trigger the operation of the analyte sensor system 308, mechanical, electrical, and / or electromechanical (or

[0127] other non-mechanical) means can be used. In addition to, or instead of, this, the analyte sensor itself may be used to trigger the analyte sensor system 308 to wake up or exit the lower power state. As an example, the measured capacitance of the analyte sensor 10, and / or the measured value of the sensor's membrane impedance, and / or the measured value of the user's skin impedance are compared with known conditions (e.g., thresholds), and this comparison can be used to indicate the embedding of the analyte sensor 10. However, after the insertion of the analyte sensor 10, if there is a delay in detecting the insertion of the analyte sensor 10, it may affect the accuracy of the analyte processing algorithm used to calculate the analyte value. Furthermore, such a delay is that the analyte sensor system 308 pairs with a display device 310, a partner device 315, etc., the measured value of the capacitance of the analyte sensor 10, and / or the measured value of the sensor's membrane impedance, and / or the measured value of the user's skin impedance are compared with known conditions (e.g., thresholds), and this comparison can be used to indicate the embedding of the analyte sensor 10. However, after the insertion of the analyte sensor 10, if there is a delay in detecting the insertion of the analyte sensor 10, it may affect the accuracy of the analyte processing algorithm used to calculate the analyte value. Furthermore, such a delay is that the analyte sensor system 308 pairs with a display device 310, a partner device 315, etc., which may be affected. Furthermore, such a delay may affect the analyte sensor system 308's pairing with a display device 310, a partner device 315, etc. Performing, such as transmitting the analyte value to the display device 310, the partner device 315, etc. It may affect performing other operations that are possible.

[0128] Use of a signal from the analyte sensor to exit a lower power state As mentioned above, embodiments of the present disclosure use, for example, the analyte sensor 10 to detect the embedding of the analyte sensor 10 into the user, including cases where the embedding is detected. And operating and / or exiting the lower power state in an accurate and power - efficient manner causing the analyte sensor system 308 to do so. In an exemplary embodiment, the analyte signal from the analyte sensor 10 is used for the purpose of operation. For example, the operation detection circuit 520 uses one or more signals from the potentiostat to generate an analyte signal, and / or, for example, detect / measure the current flow through the analyte sensor 10 (or the analyte sensor 530 in FIG. 5, although these components may be interchangeably referred to in some cases) over time. Such signals may be quantified in units such as pA (current flow), pW ( power), or count (digital value converted from an analog value such as voltage, current, power, and / or time), and these values can be used to trigger the analyte sensor system 308 to exit the lower power state. For example, a benchmark threshold in units of current may be used to trigger the wake - up or operation of the analyte sensor system 308. However, setting such a trigger based on a threshold in units of a predetermined current (e.g., count) may result in an incorrect wake - up or wake up, or wake For example, if the analyte sensor 10 is not properly embedded in the host, Even if the analyte sensor 10 is not packaged (e.g., while the analyte sensor 10 is packaged, before deployment), If a certain threshold is met (due to a potential electrostatic discharge), the device goes to a lower power state or to transition to wake-up or operational mode when the device should remain in standby or storage mode. This may be done by the analyte sensor system 308 .

[0129] Thus, embodiments of the analyte sensor system 308 generally provide measurements in units of seconds or minutes (e.g., The analyte sensor 10 may be measured over a specific period of time (e.g., 300 seconds or 5 minutes). A benchmark threshold for the current measurements (e.g., approximately X counts, where X In certain embodiments, a benchmark test is used. The thresholds identified as benchmarks can be monitored against sustained conditions and benchmarked. The threshold must be met or exceeded for a predetermined amount of time before operation is triggered. Therefore, the analyte sensor system 308 is configured to wake up reliably. For example, a sustained condition can help ensure that the Current measurements of consistent frequency over a subset of durations used for In some cases, this may include digital counting. a period for monitoring the current through the analyte sensor 10 for the purpose of operating the system 308; Unwanted anomalies such as short-term spikes in the current (or, for example, digital counts) in Based on this, it can be ensured that the benchmark threshold is not reached.

[0130] The measured current of the analyte sensor 10 (e.g., the number of received counts) can be compared with a bench mark threshold (e.g., X counts which can be approximately 9000 counts). The measured current (e.g., the number of received counts) reaches or exceeds the benchmark threshold (e.g., X counts ), it is determined that the processor 535, which is part of the activation detection circuit 520 or operates in association with the activation detection circuit 520, can start the operating mode of the analyte sensor system 308. For example, the analyte sensor system 308 can start receiving / acquiring sensor information from the analyte sensor 530. In some embodiments, for example, the estimated analyte value data is then transmitted to one or more display devices 110 and the like. That is, the processor 535 can remain active and transfer / communicate and / or process sensor information (e.g., current, digital count, etc.) to the transceiver 510 for communication with one or more display devices 110, partner devices 136, etc. However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). circuit 520 or a processor 5 35 that can operate in association with the activation detection circuit 520 can start the operating mode of the analyte sensor system 308. For example, the analyte sensor system 308 can start receiving / acquiring sensor information from the analyte sensor 530. In some embodiments, for example, the estimated analyte value data is then transmitted to one or more display devices 110 and the like. That is, the processor 535 can remain active and transfer / communicate and / or process sensor information (e.g., current, digital count, etc.) to the transceiver 510 for communication with one or more display devices 110, partner devices 136, etc. However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). can start receiving / acquiring sensor information from the analyte sensor 530. In some embodiments, for example, the estimated analyte value data is then transmitted to one or more display devices 110 and the like. That is, the processor 535 can remain active and transfer / communicate and / or process sensor information (e.g., current, digital count, etc.) to the transceiver 510 for communication with one or more display devices 110, partner devices 136, etc. However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). In some embodiments, for example, the estimated analyte value data is then transmitted to one or more display devices 110 and the like. That is, the processor 535 can remain active and transfer / communicate and / or process sensor information (e.g., current, digital count, etc.) to the transceiver 510 for communication with one or more display devices 110, partner devices 136, etc. However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). or more display devices 110, etc. That is, the processor 535 can remain active and transfer / communicate and / or process sensor information (e.g., current, digital count, etc.) to the transceiver 510 for communication with one or more display devices 110, partner devices 136, etc. However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). one or more display devices 110, partner devices 136, etc. However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). for communication with one or more display devices 110, partner devices 136, etc. However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). However, if the measured current (e.g., the number of received digital counts, etc.) is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). is determined not to reach or exceed the benchmark threshold (e.g., X counts), the analyte sensor system 308 can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). can remain in a lower power state and / or storage mode. Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). Optionally, in some cases, subsequent to the determination that the measured current (e.g., the number of received counts, etc.) reaches or exceeds the benchmark threshold (e.g., the threshold related to the count), the measured value (e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). e.g., the number of received counts, etc.) remains above a second benchmark (e.g., a count threshold) during a second period (V). to determine whether it has reached U)) or exceeded a second benchmark Another determination can be made. Thereby, for an error wake-up that may result as a result of an abnormality associated with the analyte sensor signal A more robust system can be provided be brought about

[0131] Figure 7A is a schematic diagram of an equivalent circuit model 700 of an analyte sensor 10 according to an embodiment of the present disclosure diagram. The sensor circuit model 700 can represent the electrical characteristics of the analyte sensor 10, such as an embodiment of a continuous glucose sensor The circuit 700 includes a first terminal 704 (for example , which can be a working electrode) and a second terminal 702 (for example, which can be a reference electrode) . Connected operably in series to the second terminal 702 is Rsolution712, which represents the resistance of the bulk 706 between the first terminal 704 and the second terminal 702 The bulk 706 can be, for example, a buffer solution in an example of a bench laboratory study or in an example of use as an analyte sensor 10 disposed subcutaneously a liquid (e.g., interstitial fluid) or other medium in which the analyte sensor 10 is disposed, and the bulk 706 can represent the subcutaneous tissue environment between the first terminal 704 and the second terminal 702

[0132] Connected operably to Rsolution712 are Cmembrane716, which represents the capacitance of the membrane 708 of the analyte sensor 10, and Rmembrane714, which represents the resistance of the membrane 708 of the analyte sensor 10 The parallel network of Cdouble layer718 and Rpolarization720 is operably connected to Rmembrane714 ​​​​​Continued. The parallel network of the Cdouble layer 718 and the Rpolarization 720 The workpiece represents the reaction occurring at the surface of the platinum interface of the first terminal 704. In particular, the Cdoubl e layer 718 represents the charge accumulated when the working electrode (e.g., platinum) is in the bulk 706, and the Rpolarization 720 is the polarization resistance of the electrochemical reaction that can occur at the working electrode interface 710.

[0133] In an exemplary embodiment, the non-analyte signal is generated using the analyte sensor 10 and is used to operate the analyte sensor system 308 and / or cause the analyte sensor system 308 to exit a lower power mode. One such non-analyte signal may include a signal representing a particular electrical, physical, or other characteristic of the analyte sensor 10. For example, a stimulation signal may be used to determine a particular characteristic of the analyte sensor 10.

[0134] According to an embodiment, the capacitance of the analyte sensor 10 may be detected and used to trigger the analyte sensor system 308 to operate and / or exit a lower power state. For example, the capacitance of the analyte sensor 10 may change when the membrane of the analyte sensor 10 is hydrated or placed in an environment with higher or lower humidity. The actuation detection circuit 520 may include a circuit that responds to the capacitance of the analyte sensor 10 and drives a signal (e.g., a square wave, a voltage step, an alternating current signal, etc.) that varies over time through the analyte sensor 10, and detects how the signal is affected by the capacitance of the analyte sensor 10. How the analyte sensor 10 responds to the drive signal is associated with the analyte sensor 10. can indicate the resulting capacitance. For example, to detect a threshold response to a drive signal, an analysis of the minimum level of capacitance of the analyte sensor 10 may be required. Thus, the analyte sensor system 308 can use the actuation detection circuit 520 to measure a metric indicating the capacitance of the analyte sensor 10, and based on that capacitance metric, can make a determination as to whether the analyte sensor 10 is embedded in the host. The measured capacitance may include, for example (referring to FIG. 7A by way of example), Cmembrane716, Cdouble layer71 8, and one or more of the other capacitances associated with the analyte sensor 10. It should be understood that. For example, the drive signal can pass through the analyte sensor 10 between the first terminal 702 and the second terminal 704, where the drive signal is affected by Cmembrane 716, Cdouble layer718, and other capacitances that may be associated with the analyte sensor 10, and can be used to approximate the total amount of those capacitances and / or the capacitance that can load the analyte sensor 10. 716, Cdouble layer718, and other capacitances that may be associated with the analyte sensor 10. The impedance is another characteristic of the analyte sensor 10 that can be detected and used to trigger the analyte sensor system 308 to enter a lower power state and / or end the operation. FIG. 7B shows an exemplary plot 726 of the impedance value (e.g., in units of ohms) 7

[0135] 22 of the analyte sensor 10 versus time (e.g., in units of seconds) from embedding 724. As shown, the impedance value 722 of the analyte sensor 10 can begin to decrease after a certain time (e.g., 30 seconds) following embedding. Further shown, the impedance value 722 of the analyte sensor 10 can begin to decrease after a certain time (e.g., 30 seconds) following embedding. As further shown, the impedance value 722 of the analyte sensor 10 can begin to decrease after a certain time (e.g., 30 seconds) following embedding. As further shown, the impedance value 722 of the analyte sensor 10 can begin to decrease after a certain time (e.g., 30 seconds) following embedding. As further shown, the impedance value 722 of the analyte sensor 10 can begin to decrease after a certain time (e.g., 30 seconds) following embedding. As further shown, the impedance value 722 of the analyte sensor 10 can begin to decrease after a certain time (e.g., 30 seconds) following embedding. As further shown, the impedance After an initial decay of the dance value 722, the impedance value 722 generally stabilizes after a certain time following the implantation of the analyte sensor 10. Changes that may result from the implantation of the analyte sensor 10 (e.g., a decrease in the impedance value 722, or a change rate of the impedance value, etc.) can be used to detect / trigger an operation. Following the implantation of the analyte sensor 10, the impedance value 722 generally stabilizes after a certain time. Changes that may result from the implantation of the analyte sensor 10 (e.g., a decrease in the impedance value 722, or a change rate of the impedance value, etc.) can be used to detect / trigger an operation. Following the implantation of the analyte sensor 10, the impedance value 722 generally stabilizes after a certain time. Changes that may result from the implantation of the analyte sensor 10 (e.g., a decrease in the impedance value 722, or a change rate of the impedance value, etc.) can be used to detect / trigger an operation. Following the implantation of the analyte sensor 10, the impedance value 722 generally stabilizes after a certain time. Changes that may result from the implantation of the analyte sensor 10 (e.g., a decrease in the impedance value 722, or a change rate of the impedance value, etc.) can be used to detect / trigger an operation.

[0136] Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body. Figure 7C illustrates another exemplary plot 734 of the impedance value 730 (e.g., in units of ohms). Figure 7C provides a plot of the impedance value 730 versus hydration 732 (e.g., in units of %), and the hydration 732 can be the hydration associated with the membrane of the analyte sensor 10. Generally, the humidity outside the human body can cause a membrane hydration level that may be lower than the hydration level normally associated with the membrane when the analyte sensor 10 is inside the human body. Thus, the moisture in the environment and the resulting hydration level (e.g., of the membrane of the analyte sensor 10) can be used to indicate whether the analyte sensor 10 is implanted inside the host's body or not. Additionally, in some cases, specific environmental conditions (e.g., humidity) can cause the operation of the analyte sensor system 308 even when the analyte sensor 10 is not inserted into the host's body.

[0137] In addition, the measurable electrical characteristics associated with the analyte sensor 10 can vary as a function of environmental humidity, moisture, and / or membrane hydration. Such variations in the measurable electrical characteristics (e.g., impedance, capacitance, etc.) as a function of humidity, moisture, and / or hydration can, in some cases, cause the measurable electrical characteristics to affect the operation of the analyte sensor system 308. In addition, the measurable electrical characteristics associated with the analyte sensor 10 can vary as a function of environmental humidity, moisture, and / or membrane hydration. Such variations in the measurable electrical characteristics (e.g., impedance, capacitance, etc.) as a function of humidity, moisture, and / or hydration can, in some cases, cause the measurable electrical characteristics to affect the operation of the analyte sensor system 308. In addition, the measurable electrical characteristics associated with the analyte sensor 10 can vary as a function of environmental humidity, moisture, and / or membrane hydration. Such variations in the measurable electrical characteristics (e.g., impedance, capacitance, etc.) as a function of humidity, moisture, and / or hydration can, in some cases, cause the measurable electrical characteristics to affect the operation of the analyte sensor system 308. In addition, the measurable electrical characteristics associated with the analyte sensor 10 can vary as a function of environmental humidity, moisture, and / or membrane hydration. Such variations in the measurable electrical characteristics (e.g., impedance, capacitance, etc.) as a function of humidity, moisture, and / or hydration can, in some cases, cause the measurable electrical characteristics to affect the operation of the analyte sensor system 308. cause it to operate or, for example, directly use humidity, hydration, and / or moisture levels Rather than doing so, the analyte sensor system 308 may be made to function as a more reliable indicator for terminating a lower power state. For example, in some cases, humidity, moisture, and / or membrane hydration may increase for reasons other than the analyte sensor 10 being inserted into a host (e.g., a high moisture level within the packaging of the analyte sensor system 308), and thus may trigger an incorrect wake-up of the analyte sensor system 308. Accordingly, by utilizing the relationship between humidity / moisture and certain measurable electrical characteristics (e.g., impedance, capacitance, etc.) of the analyte sensor 10, the insertion event of the analyte sensor 10 can be detected more accurately and, in response, the analyte sensor system 308 can be

[0138] caused to operate. For example, under lower humidity conditions (e.g., 90% RH), the impedance may be relatively high (e.g., 10 MΩ). However, when the analyte sensor 10 is embedded, the impedance may, in some cases, decrease relatively rapidly (e.g., down to several hundred kΩ). Accordingly, in embodiments, a change, rate of change, and / or threshold impedance value (e.g., by way of a specific but non-limiting example, approximately 300 - 500 kΩ) can be used to distinguish between high humidity conditions that may occur in a non-inserted environment outside the host body on the one hand, and moisture conditions that may occur in relation to the analyte sensor 10 being embedded within the host body on the other hand. This can prevent the can be useful to stop (or resist). The desirable level of impedance threshold can be based on the time allocated to the wake-up trigger time window of the analyte sensor system 308 after the insertion of the analyte sensor 10. For example, it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, it can be based on the time that can be allocated to the wake-up trigger time window of the analyte sensor system 308 after the insertion of the analyte sensor 10. For example, it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more.

[0139] As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, it can be based on the time that can be allocated to the wake-up trigger time window of the analyte sensor system 308 after the insertion of the analyte sensor 10. For example, it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, it can be based on the time that can be allocated to the wake-up trigger time window of the analyte sensor system 308 after the insertion of the analyte sensor 10. For example, it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, it can be based on the time that can be allocated to the wake-up trigger time window of the analyte sensor system 308 after the insertion of the analyte sensor 10. For example, it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. As shown in FIG. 7C, for the pre-implant hydration 736 (e.g., in % units) of the analyte sensor system 10, the point 740 on the plot 734 corresponds to an impedance value 738 (e.g., in Ω). In addition, for the hydration 756 following the implantation of the analyte sensor 10, the point 760 corresponds to an impedance value 758. In an embodiment, the impedance value 758 may be significantly lower than the impedance value 738. As a result, the range of impedance values between the impedance value 744 and the impedance value 750, corresponding to the points 746 and 752 on the plot 734 respectively, can be used as a threshold for detecting the implantation of the analyte sensor 10 and thus can be used to trigger the analyte sensor system 308 to operate and / or terminate in a lower power state. In additional or other examples, the slope or derivative of the impedance value as a function of hydration can be monitored to detect the implantation of the analyte sensor 10. Thus, for example, the impedance of the analyte sensor 10 can be monitored, and when the impedance crosses the impedance threshold, it can be based on the time that can be allocated to the wake-up trigger time window of the analyte sensor system 308 after the insertion of the analyte sensor 10. For example, it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. it can be based on the time that can be allocated to the wake-up trigger time window of the analyte sensor system 308 after the insertion of the analyte sensor 10. For example, it can be a trade-off between robustness of the state against false wake-up based on, e.g., noise, signal magnitude, inaccuracy of circuit measurements, etc. Examples of achievable wake-up trigger times can include, but are not limited to, approximately less than 30 seconds to approximately 60 seconds or more. occurs (e.g., achieves a threshold derivative, gradient, or other condition), and the operation or change in state of the analyte sensor system 308 can be triggered. In a particular example, before the analyte sensor 10 is inserted, it can have an associated impedance of approximately 10 MΩ at a relatively lower hydration value (e.g., within a range of values typical of the environmental humidity outside the host's body or within a particular environment). Next, after the analyte sensor 10 is inserted into the user's body, as the hydration increases, the impedance value of the analyte sensor 10 can decrease to approximately 100 kΩ. outside or within a range of values typical of the environmental humidity in a particular environment). Next, after the analyte sensor 10 is inserted into the user's body, as the hydration increases, the impedance value of the analyte sensor 10 can decrease to approximately 1 00 kΩ. 00 kΩ. can decrease to approximately 1

[0140] The impedance associated with the analyte sensor 10 can be measured using various techniques, including, for example, using a voltage or current step function or other function or signal, such as those described in U.S. Patent No. 9,801,575, which is hereby incorporated by reference in its entirety, or using any other known method as described therein), or using any other known method using electrochemical impedance spectroscopy, or using any other known method as described in U.S. Patent No. 9,801,575, which is hereby incorporated by reference in its entirety. By way of example, the actuation detection circuit 520 can include an operation of a driver circuit (e.g., a function generator, an oscillator, etc.) for generating a step function or other function or signal that can be used to measure the impedance of the analyte sensor 10. For example, a voltage associated with the step function or other signal is applied to the analyte sensor 10, and the resulting current between the terminals of the analyte sensor 10 can be detected using the actuation detection circuit 520. Next, in an exemplary implementation, the impedance of the analyte sensor 10 can be calculated using the relationship between the applied voltage and the resulting current. used to measure the impedance of the analyte sensor 10, or other function or signal, and the resulting current between the terminals of the analyte sensor 10 can be detected using the actuation detection circuit 520. Next, in an exemplary implementation, the impedance of the analyte sensor 10 can be calculated using the relationship between the applied voltage and the resulting current. used to measure the impedance of the analyte sensor 10, or other function or signal, and the resulting current between the terminals of the analyte sensor 10 can be detected using the actuation detection circuit 520. Next, in an exemplary implementation, the impedance of the analyte sensor 10 can be calculated using the relationship between the applied voltage and the resulting current. For example, a voltage associated with the step function or other signal is applied to the analyte sensor 10, and the resulting current between the terminals of the analyte sensor 10 can be detected using the actuation detection circuit 520. Next, in an exemplary implementation, the impedance of the analyte sensor 10 can be calculated using the relationship between the applied voltage and the resulting current. For example, a voltage associated with the step function or other signal is applied to the analyte sensor 10, and the resulting current between the terminals of the analyte sensor 10 can be detected using the actuation detection circuit 520. Next, in an exemplary implementation, the impedance of the analyte sensor 10 can be calculated using the relationship between the applied voltage and the resulting current. For example, a voltage associated with the step function or other signal is applied to the analyte sensor 10, and the resulting current between the terminals of the analyte sensor 10 can be detected using the actuation detection circuit 520. Next, in an exemplary implementation, the impedance of the analyte sensor 10 can be calculated using the relationship between the applied voltage and the resulting current. For example, a voltage associated with the step function or other signal is applied to the analyte sensor 10, and the resulting current between the terminals of the analyte sensor 10 can be detected using the actuation detection circuit 520. Next, in an exemplary implementation, the impedance of the analyte sensor 10 can be calculated using the relationship between the applied voltage and the resulting current.

[0141] Generally, to reduce / minimize the power consumption of the battery and avoid sending more current to the analyte sensor 10 than is necessary or appropriate, any impedance measurements performed for the purpose of operation should use a waveform of relatively low amplitude (e.g., less than approximately 50 mV), preferably a net current of zero (e.g., centered around an electrode voltage bias of 0 V). In an embodiment, as described above, the measured value indicating impedance can be characterized using an actuation detection circuit 520 by applying a voltage (e.g., a step function) to the analyte sensor 10. The magnitude of the resulting current flow (which may include current spikes) can be inversely proportional to the impedance of the membrane of the analyte sensor 10. Thus, using Ohm's law, the impedance can be determined, for example, but not limited to, by monitoring voltage, current, and / or one or both digital counts. To avoid sending more current to the analyte sensor 10 than is necessary or appropriate for the purpose of operation, any impedance measurements should use a waveform of relatively low amplitude (e.g., less than approximately 50 mV), preferably a net current of zero (e.g., centered around an electrode voltage bias of 0 V). In an embodiment, as described above, the measured value indicating impedance is characterized using an actuation detection circuit 520 by applying a voltage (e.g., a step function) to the analyte sensor 10. The magnitude of the resulting current flow (which may include current spikes) can be inversely proportional to the impedance of the membrane of the analyte sensor 10. Thus, using Ohm's law, the impedance can be determined, for example, but not limited to, by monitoring voltage, current, and / or one or both digital counts. The actuation detection circuit 520 can include a circuit that detects whether the impedance is above or below a set level. Such a circuit is discussed in more detail below with respect to at least FIGS. 8A and 12 - 14. With respect to FIG. 8A, at a high level, the circuit can capture positive current spikes using a switch that can be driven using a voltage source that can apply, for example, a square wave or other waveform to the analyte sensor 10. Next, the positive current can be used to charge a capacitor. The voltage that can occur across the capacitor

[0142] can represent a measured value of the impedance of the analyte sensor 10 (e.g., measured based on a voltage divider that can be placed between the impedance of the analyte sensor 10 and a known impedance). FIGS. 12 - 14. With respect to FIG. 8A, at a high level, the circuit can capture positive current spikes using a switch that can be driven using a voltage source that can apply, for example, a square wave or other waveform to the analyte sensor 10. Next, the positive current can be used to charge a capacitor. The voltage that can occur across the capacitor can represent a measured value of the impedance of the analyte sensor 10 (e.g., measured based on a voltage divider that can be placed between the impedance of the analyte sensor 10 and a known impedance). Next, the positive current can be used to charge a capacitor. The voltage that can occur across the capacitor can represent a measured value of the impedance of the analyte sensor 10 (e.g., measured based on a voltage divider that can be placed between the impedance of the analyte sensor 10 and a known impedance). can represent a measured value of the impedance of the analyte sensor 10 (e.g., measured based on a voltage divider that can be placed between the impedance of the analyte sensor 10 and a known impedance). can represent a measured value of the impedance of the analyte sensor 10 (e.g., measured based on a voltage divider that can be placed between the impedance of the analyte sensor 10 and a known impedance). (so as to be). By using a voltage comparator circuit set to a desired level, the analysis to determine the insertion of the analyte sensor 10 and trigger the analyte sensor system 308 to use the insertion of the analyte sensor 10 to end the lower power state. Such a circuit can be designed and integrated into a chip that operates at very low power (e.g., less than 1 μA during the lower power state). When the embedding of the analyte sensor 10 is detected, the chip and / or circuit can send a control signal to the processor 535 to cause the analyte sensor system 308 to end the lower power state.

[0143] In an embodiment, a voltage - current amplifier and additional switches are used to disconnect the analyte sensor 10 from the detection circuit after the analyte sensor system 308 ends the lower power state. It should also be noted that under high humidity conditions (such as may occur during storage), the net current through the analyte sensor 10 may be limited. This can provide an advantage over techniques for operating the analyte sensor system 308 that apply a fixed bias (e.g., a voltage such as 0.6 V) to the analyte sensor 10. When such a technique is used, under high humidity conditions, the current flowing through the analyte sensor 10 as a result of the application of the fixed bias may consume an undesired amount of power and / or affect the performance of the analyte sensor 10.

[0144] Turning now to FIG. 8A, an exemplary actuation detection circuit 800 according to an embodiment of the present disclosure is illustrated. The circuit 800 is used, for example, to operate the analyte sensor system 308 Can be used to detect current in a lower power wake-up circuit . At a high level, referring to FIG. 5 as an example of a particular embodiment and situation, circuit 800 can generate voltage pulses using the inrush (e.g., charging) current through the capacitance of analyte sensor 530. The voltage pulses can be monitored by a detection circuit, and if the pulses satisfy one or more conditions, the analyte sensor system 308 can be triggered to exit a lower power state. As an example, in a particular embodiment, a certain number of pulses exceeding a voltage threshold can trigger the operation of the analyte sensor system 308. Additional examples are described below. Using components such as one or more switches and one or more current limiting resistors in circuit 800, a more accurate detection of the embedded event of analyte sensor 530 can be achieved, and thus, a more robust control can be provided for causing the analyte sensor system 308 to operate or to exit a lower power mode. For example, at a first time point, a switch can be used to couple a first terminal of the analyte sensor 530 to a potentiostat or other measurement device or other measurement circuit. The detection

[0145] circuit can include, in a particular example, an amplification element (e.g., a comparator, a low noise amplifier, other amplifiers, etc.) and / or other circuits. The detection circuit can detect whether the voltage generated using circuit 800 exceeds a threshold or otherwise meets one or more conditions based on the (e.g., charging) current that can flow through the capacitance of the analyte sensor 530. Whether the voltage exceeds the condition(s) or not can be used to detect. Whether the voltage exceeds the condition(s) or not can cause the analyte sensor system 308 to operate or to exit a lower power mode. For example example, at a first time point, a switch can be used to couple a first terminal of the analyte sensor 530 to a potentiostat or other measurement device or other measurement circuit. The detection circuit can include, in a particular example, an amplification element (e.g., a comparator, a low noise amplifier, other amplifiers, etc.) and / or other circuits. The detection circuit can detect whether the voltage generated using circuit 800 exceeds a threshold or otherwise meets one or more conditions based on the (e.g., charging) current that can flow through the capacitance of the analyte sensor 530. Whether the voltage exceeds the condition(s) or not can be coupled to a potentiostat or other measurement device or other measurement circuit. The detection circuit can include, in a particular example, an amplification element (e.g., a comparator, a low noise amplifier, other amplifiers, etc.) and / or other circuits. The detection circuit can detect whether the voltage generated using circuit 800 exceeds a threshold or otherwise meets one or more conditions based on the (e.g., charging) current that can flow through the capacitance of the analyte sensor 530. Whether the voltage exceeds the condition(s) or not and / or other circuits. The detection circuit can detect whether the voltage generated using circuit 800 exceeds a threshold or otherwise meets one or more conditions based on the (e.g., charging) current that can flow through the capacitance of the analyte sensor 530. Whether the voltage exceeds the condition(s) or not can flow through (e.g., charge) and is used to detect whether the voltage generated using circuit 800 exceeds a threshold or otherwise meets one or more conditions. Whether the voltage exceeds the condition(s) or not or otherwise meets one or more conditions. Whether the voltage exceeds the condition(s) or not can be detected using. Whether the voltage exceeds the condition(s) or not If additional condition(s) are met, the operation of the analyte sensor system 308 can be triggered. For example, such a voltage can be generated using the current-voltage conversion action of components included in or used by a circuit 800, such as capacitor 834, switch element 818, and / or driver circuit 806.

[0146] And, for example, at a second time point, a switch that can be used to couple the first terminal of the analyte sensor 530 to a measurement device (e.g., a potentiostat) is opened or placed in a high-impedance state to disconnect the first terminal of the analyte sensor 530 from the measurement device / potentiostat, while a second switch couples the first and second terminals of the analyte sensor 530 to each other, for example, via a current limiting resistor, to at least substantially discharge the capacitance of the analyte sensor 530. In this way, the potential that may exist across the analyte sensor 530 can be set, reset, and / or zeroed. This effectively resets the circuit so that inrush events of charging current through the capacitance of the analyte sensor 530 are repeated, thus enabling another detectable event and potentially providing a more robust operation detection mechanism for the analyte sensor system 308. In some cases, this Or it can be operated accurately.

[0147] More specifically, FIG. 8A illustrates a circuit 800 including an analyte sensor 808 and a measurement device 81. 0 (e.g., a potentiostat). In this regard, the analyte sensor 808 may be, for example, similar to the analyte sensor 530 referenced in connection with FIG. It will be apparent to those of ordinary skill in the art upon studying this disclosure that the same, substantially similar, or the same may be used. It will be understood that in certain embodiments, the analyte sensor 808 is Depending on the situation and / or application in which the sensors 530 and / or 808 may be used, the analysis The measuring device 810 may be at least partially different from the analyte sensor 530. 808 and / or a host in which the analyte sensor 808 is embedded. Analyte sensor 808 that can be used to calculate the level of the analyte in the test. It can be used to collect information from

[0148] In addition, the circuit 800 may include a capacitive element 834 and, optionally, a resistive element 832. The circuit 800 may also include a detection circuit 802, which may include any of a number of In the case of, for example, an amplifying element (e.g., a comparator) may be used or included. In addition, the circuit 800 includes a reference voltage 804, a reference voltage 818, and, for example, a clock-based driver. The reference voltage 804 and the driver circuit 806 may include one or more of the following: It should be understood that one or more of 818 and 819 may be substituted for other reference signals. It should also be understood that path 806 may be driven by a signal other than a clock signal.

[0149] In an embodiment, a current-based operating approach for the analyte sensor system 308 can be implemented using a circuit similar to circuit 800 shown in FIG. 8A However, certain modifications can be made in relation to some such embodiments. For example, switch element 812 may not be present in circuit 800, or may be, for example, bypassed or short-circuited Switch element 814 may also not be present, or may be effectively removed from circuit 800, and / or may be placed in a high-impedance state or an open-circuit state In such a case, resistor element 832 may also be effectively removed from circuit 800 It should be understood that other means may be used to effectively remove and / or bypass resistor element 832. In an embodiment, the embedding of the analyte sensor 808 is still determined / monitored based on detecting a specific (e.g., sufficient) current flow(s) between the first terminal 828 and the second terminal 830 of the analyte sensor 808

[0150] Here, exemplary features of such a modification or a similar version of circuit 800 are provided as follows. Measurement device 810 can apply a potential (e.g., a substantially continuous voltage) between terminals 828 and 830 of analyte sensor 830. For example, terminal 82 8 can be placed at a higher potential than terminal 830 such that a current flow through analyte sensor 808 can be supplied through terminal 824 of measurement device 810 (e.g., in some cases a potentiostat) 0. Additionally, for example, terminal 826 of measurement device 810 and terminal 830 of analyte sensor 808 are connected to each other and / or to a current-voltage conversion circuit 8 can be placed at a higher potential than terminal 830 such that a current flow through analyte sensor 808 can be supplied through terminal 824 of measurement device 810 (e.g., in some cases a potentiostat) 8 can be placed at a higher potential than terminal 830 such that a current flow through analyte sensor 808 can be supplied through terminal 824 of measurement device 810 (e.g., in some cases a potentiostat) 8 can be placed at a higher potential than terminal 830 such that a current flow through analyte sensor 808 can be supplied through terminal 824 of measurement device 810 (e.g., in some cases a potentiostat) and terminal 830 of the analyte sensor 808 are connected to each other and / or to a current-voltage conversion circuit ​​​​​can be combined.

[0151] In an embodiment, the current-voltage conversion circuit may be coupled to terminals 826 and 830 at a first end and may be coupled to a reference voltage 818 (e.g., ground) at a second end, and may include a capacitive element 83 4. The first end of the capacitive element may also be coupled to the switching element 816 . The switching element 816 may be driven by a drive circuit 806, which may include and / or use a clock-based or other signal type driver. The switching element 816 may thus alternately couple and decouple terminals 826 and 830 to the reference voltage 818. Terminals 826 and 830 may be periodically coupled and decoupled to the reference voltage 818 according to a configurable, programmable, adaptive, and / or variable interval / frequency (e.g., 10 Hz). In some cases, the driver circuit 806 may make the coupling / decoupling of terminals 826 and 830 to / from the reference voltage 818 aperiodic, asynchronous, and / or event-driven.

[0152] In one example, when the switch element 816 is placed in a higher impedance state or opened, e.g., at a first time, terminals 826 and 830 may be disconnected or decoupled from the reference voltage 818 (e.g., may be floating). Thus, the current flowing through the capacitance of the analyte sensor 808 can be effectively fed as a charging current to the capacitive element 834. This charging current may generate a potential across the capacitive element 834. When the switch element 816 is placed in a lower impedance or conductive state or closed, e.g., at a second time, terminals 826 and 830 may, in some cases, It may be directly connected or coupled to a reference voltage 818 (e.g., ground). In this configuration, the charge that can be stored in the capacitive element 834 can be discharged at least substantially (e.g., to ground), so that the potential that can occur between both ends of the capacitive element 834 can be returned / resetted near the potential of at least the reference voltage 818 (e.g., ground or 0V). Thus, in this example, when a current flows through the capacitance of the analyte sensor 808 by the action of the switch element 816, the resulting voltage signal waveforms that may exist at the terminals 826 and 830 can represent a series of voltage pulses (e.g., the voltage across the capacitive element 834 as a function of time), and such pulses can be proportional to the magnitude of the current passing through the capacitance of the analyte sensor 808. The charge that can be stored in the capacitive element 834 can be discharged at least substantially (e.g., to ground), so that the potential that can occur between both ends of the capacitive element 834 can be returned / resetted near the potential of at least the reference voltage 818 (e.g., ground or 0V). The charge that can be stored in the capacitive element 834 can be discharged at least substantially (e.g., to ground), so that the potential that can occur between both ends of the capacitive element 834 can be returned / resetted near the potential of at least the reference voltage 818 (e.g., ground or 0V). The charge that can be stored in the capacitive element 834 can be discharged at least substantially (e.g., to ground), so that the potential that can occur between both ends of the capacitive element 834 can be returned / resetted near the potential of at least the reference voltage 818 (e.g., ground or 0V). Thus, in this example, when a current flows through the capacitance of the analyte sensor 808 by the action of the switch element 816, the resulting voltage signal waveforms that may exist at the terminals 826 and 830 can represent a series of voltage pulses (e.g., the voltage across the capacitive element 834 as a function of time), and such pulses can be proportional to the magnitude of the current passing through the capacitance of the analyte sensor 808. Thus, in this example, when a current flows through the capacitance of the analyte sensor 808 by the action of the switch element 816, the resulting voltage signal waveforms that may exist at the terminals 826 and 830 can represent a series of voltage pulses (e.g., the voltage across the capacitive element 834 as a function of time), and such pulses can be proportional to the magnitude of the current passing through the capacitance of the analyte sensor 808. the resulting voltage signal waveforms that may exist at the terminals 826 and 830 can represent a series of voltage pulses (e.g., the voltage across the capacitive element 834 as a function of time), and such pulses can be proportional to the magnitude of the current passing through the capacitance of the analyte sensor 808. the resulting voltage signal waveforms that may exist at the terminals 826 and 830 can represent a series of voltage pulses (e.g., the voltage across the capacitive element 834 as a function of time), and such pulses can be proportional to the magnitude of the current passing through the capacitance of the analyte sensor 808. the resulting voltage signal waveforms that may exist at the terminals 826 and 830 can represent a series of voltage pulses (e.g., the voltage across the capacitive element 834 as a function of time), and such pulses can be proportional to the magnitude of the current passing through the capacitance of the analyte sensor 808. the resulting voltage signal waveforms that may exist at the terminals 826 and 830 can represent a series of voltage pulses (e.g., the voltage across the capacitive element 834 as a function of time), and such pulses can be proportional to the magnitude of the current passing through the capacitance of the analyte sensor 808.

[0153] Continuing with this example, in the circuit 800, the input 822 of the detection circuit 802 (e.g., a voltage detection circuit that can be implemented as an amplification element, a comparator, other circuits, etc.) can be coupled to the terminals 826 and 830. In an embodiment, the detection circuit 802 is operable to compare the voltage across the capacitive element 834 with a reference voltage 804 that can be configurable, programmable, variable, adaptable, etc. The detection circuit 802 can be further operable to generate an output 836 that can be used, for example, to trigger the operation of the analyte sensor 308 when certain conditions (single or plural) are achieved (e.g., when the voltage across the capacitive element 834 exceeds, is below, or is within the range of the reference voltage 804, or exhibits a specific tendency, etc.). The reference voltage 804 can be configured based on calibration, can be set according to a predetermined value / characteristic, and / or can be adjusted according to the situation or current conditions. The input 822 of the detection circuit 802 (e.g., a voltage detection circuit that can be implemented as an amplification element, a comparator, other circuits, etc.) can be coupled to the terminals 826 and 830. The input 822 of the detection circuit 802 (e.g., a voltage detection circuit that can be implemented as an amplification element, a comparator, other circuits, etc.) can be coupled to the terminals 826 and 830. In an embodiment, the detection circuit 802 is operable to compare the voltage across the capacitive element 834 with a reference voltage 804 that can be configurable, programmable, variable, adaptable, etc. In an embodiment, the detection circuit 802 is operable to compare the voltage across the capacitive element 834 with a reference voltage 804 that can be configurable, programmable, variable, adaptable, etc. The detection circuit 802 is operable to generate an output 836 that can be used, for example, to trigger the operation of the analyte sensor 308 when certain conditions (single or plural) are achieved (e.g., when the voltage across the capacitive element 834 exceeds, is below, or is within the range of the reference voltage 804, or exhibits a specific tendency, etc.). The detection circuit 802 is operable to generate an output 836 that can be used, for example, to trigger the operation of the analyte sensor 308 when certain conditions (single or plural) are achieved (e.g., when the voltage across the capacitive element 834 exceeds, is below, or is within the range of the reference voltage 804, or exhibits a specific tendency, etc.). The detection circuit 802 is operable to generate an output 836 that can be used, for example, to trigger the operation of the analyte sensor 308 when certain conditions (single or plural) are achieved (e.g., when the voltage across the capacitive element 834 exceeds, is below, or is within the range of the reference voltage 804, or exhibits a specific tendency, etc.). The detection circuit 802 is operable to generate an output 836 that can be used, for example, to trigger the operation of the analyte sensor 308 when certain conditions (single or plural) are achieved (e.g., when the voltage across the capacitive element 834 exceeds, is below, or is within the range of the reference voltage 804, or exhibits a specific tendency, etc.). The reference voltage 804 can be configured based on calibration, can be set according to a predetermined value / characteristic, and / or can be adjusted according to the situation or current conditions. Note that the field analyte sensor system 308 can be configured based on the environmental conditions it experiences. Furthermore, the detection circuit 802 can count and / or otherwise characterize or measure some sequential voltage pulses that can meet (e.g., reach or exceed) a threshold value, and can operate and / or use a configurable digital logic circuit (not shown in FIG. 8A) that is operable to do so. For example, if the number and / or characteristics of the measured / monitored pulses meet configurable conditions (e.g., the number / magnitude of the threshold values), the output 836 indicates that the analyte sensor system 308 should operate to terminate or cause to terminate or trigger to terminate a lower power state.

[0154] However, in certain cases, the above examples may be more particularly suitable for use in conjunction with a particular electrical model of the analyte sensor 808. For example, the above exemplary circuit may be more suitable for an implementation where the analyte sensor 808 is modeled as a substantially or purely resistive load between the terminals 828 and 830 of the analyte sensor 808. However, in certain examples, this substantially resistive load may not be an approximate representation of the analyte sensor 808. By way of illustration, in the case of a substantially or purely resistive load, the voltage pulse that may occur across the capacitive element 834 as a result of the charging current may be substantially constant in amplitude for a given substantially constant current. Thus, the amplitude of the voltage pulse may increase in proportion to an increase in the current.

[0155] However, as described above in connection with FIG. 7A, in an embodiment, the analyte sensor 808 The electrical behavior is not accurately modeled by a substantially or purely resistive load Instead, for example, as illustrated in FIG. 7A, a more complex passive circuit model is used that includes both a capacitor and a resistor and may include other elements to more accurately electrically model the analyte sensor 808 For example, if the relatively large double layer capacitance C of the analyte sensor 808 is included in the electrical model used when the terminals 828 and 830 of the analyte sensor 808 are first connected into the circuit 800, the circuit 800 may operate in a different manner In some cases, the difference may be significant or recognizable As an illustration, instead of a constant amplitude voltage pulse sequence or train that may result when a resistive model / load is used (e.g., as described in the above example in connection with FIG. 6), the waveform characteristics of the voltage across the capacitive element 834 are substantially affected (and in some cases dominated) by the initial rush of charging current that can flow through the capacitance of the analyte sensor 808 This can result in a (e.g., series of) voltage pulses having an initially larger amplitude followed by a decreasing amplitude The amplitude may decrease rapidly in some cases, for example, according to an exponential decay associated with the resistance / capacitance (RC) characteristics of the electrical equivalent model of the analyte sensor 808 shown as an example in FIG. 7A Here, reference is made to FIG. 8B as an example, which is discussed in more detail below As shown in FIG. 8B, for example, the pulses that may be included in the waveform 870 exhibit an exponential decay during the period 845 However, if a resistive model is used for the analyte sensor 808, this decay may not be present, and instead, the waveform 870 of FIG. 8B may have a constant amplitude as shown in FIG. 8B as shown in FIG. 8B As shown in FIG. 8B, for example, the pulses that may be included in the waveform 870 may have a constant amplitude during the period 845 is used for the analyte sensor 808, this decay may not be present, and instead, the waveform 870 It should be understood that the pulse may have a relatively constant amplitude.

[0156] Furthermore, when the capacitance of the analyte sensor 808 is charged and the current flow is mainly due to the steady-state current, the operation of the current-voltage circuit may remain significantly affected by the presence of the charged capacitor. For example, when a more complex electrical model is used, the amplitude of the residual voltage pulse that may be measurable across the capacitive element 834 for a given steady-state current may be significantly lower than the equivalent steady-state current that exists under the resistive load electrical model of the analyte sensor 808. Furthermore, the proportional difference in the magnitude of the corresponding voltage waveforms for two different currents may no longer be sufficiently distinguishable by the detection circuit 802 under normal circumstances. For example, the detection circuit 802 may not be able to accurately detect a threshold crossing, etc., due to the relatively small or decreased difference in the amplitude of the steady-state voltage pulse that may result when the electrical model of FIG. 7A is used. For example, when the electrical model of FIG. 7A is used, the detection circuit 802 may not be able to accurately detect a threshold crossing, etc., due to the relatively small or decreased difference in the amplitude of the steady-state voltage pulse that may result.

[0157] Therefore, considering the above, it should be understood that the exemplary configuration of the circuit 800 described above may generate a steady-state current that does not result in a voltage pulse waveform of sufficient magnitude for detection or discrimination by the detection circuit 802. Therefore, this exemplary configuration of the circuit 800 may not facilitate the accurate and robust operation of the analyte sensor system 308. For example, there may be only a single or a few opportunities to generate a voltage waveform that can be more easily / accurately / reliably detected by the detection circuit 802. For example, the initial relatively large voltage pulse that may result from the initial influx of the charging current is a single detection event. ​​​​​​​​​​​can only provide. Also, if this initial relatively large pulse or pulses are not detected by circuit 802, or if the analyte sensor system 308 does not operate as a result of the initial pulse(s), for example, the analyte sensor 808 may not be sufficiently hydrated when connected to circuit 800, circuit 800 may not have another sufficiently detectable opportunity to detect / evaluate the embedding of analyte sensor 8 08.

[0158] Accordingly, embodiments of the present disclosure include a configuration of circuit 800 that can be reset by circuit components such as switches and other elements. For example, referring further to FIG. 8A, circuit 800 may include switch elements 812 and 814. Switch elements 812, 814, and 816 may be implemented using discrete or integrated components, such as electrical components including transistors or other passive / active devices (e.g., FET switches, etc.). As will be discussed in more detail below, switch elements 812 and 814 may be complementary such that when one switch element is closed, the other may be opened, and vice versa. Switch elements 812 and 814 may be controlled using a clock or other signal driver, and in some cases, this clock may be derived from the clock or other source / drive signal used by driver circuit 806. In an embodiment, switch elements 812 and 814 may be controlled by a clock or other source having a lower frequency than the clock or other source that may be used by driver circuit 806. For example, the frequency (e.g., clock) of switch elements 812 and 814 may be complementary such that when one switch element is closed, the other may be opened, and vice versa. Switch elements 812 and 814 may be controlled using a clock or other signal driver, and in some cases, this clock may be derived from the clock or other source / drive signal used by driver circuit 806. In an embodiment, switch elements 812 and 814 may be controlled by a clock or other source having a lower frequency than the clock or other source that may be used by driver circuit 806. For example, the frequency (e.g., clock) of switch elements 812 and 814 or other signal driver, and in some cases, this clock may be derived from the clock or other source / drive signal used by driver circuit 806. In an embodiment, switch elements 812 and 814 may be controlled by a clock or other source having a lower frequency than the clock or other source that may be used by driver circuit 806. For example, the frequency (e.g., clock) of switch elements 812 and 814 or other signal driver, and in some cases, this clock may be derived from the clock or other source / drive signal used by driver circuit 806. In an embodiment, switch elements 812 and 814 may be controlled by a clock or other source having a lower frequency than the clock or other source that may be used by driver circuit 806. For example, the frequency (e.g., clock) of switch elements 812 and 814 may be controlled by a clock or other source having a lower frequency than the clock or other source that may be used by driver circuit 806. For example, the frequency (e.g., clock) of switch elements 812 and 814 or other signal driver, and in some cases, this clock may be derived from the clock or other source / drive signal used by driver circuit 806. In an embodiment, switch elements 812 and 814 may be controlled by a clock or other source having a lower frequency than the clock or other source that may be used by driver circuit 806. For example, the frequency (e.g., clock) of switch elements 812 and 814 or other signal driver, and in some cases, this clock may be derived from the clock or other source / drive signal used by driver circuit 806. In an embodiment, switch elements 812 and 814 may be controlled by a clock or other source having a lower frequency than the clock or other source that may be used by driver circuit 806. For example, the frequency (e.g., clock) of switch elements 812 and 814 ​​The number can be a fraction of the (e.g., clock) frequency of the switching element 816 and can be used The value of the fraction obtained can be configurable, programmable, adaptable, and / or variable . As examples / options of the fraction, in some cases, 1 / 10, 1 / 20, 1 / 40, 1 / 80, etc. can be mentioned. Thus, for each of these examples / options, the switching elements 812 and 814 can change their states every 10, 20, 40, or 80 cycles of the clock of the switching element 816 . Other ratios and relationships that can be set regarding the control of the driver circuit 806 and the switching elements 812 and 814 will be understood by considering the present disclosure .

[0159] The output 836 of the detection circuit 802 can be coupled, for example, to the processor 5 35 of the analyte sensor system 308, so the output 836 can be used for the operation or triggering of the analyte sensor system 308 . The circuit 800 can be implemented within or in association with the operation detection circuit 520 . If the circuit 800 is implemented as the operation detection circuit 520 or as part of the operation detection circuit 520 , the output 836 can be coupled to the processor 535, so when signaled as such, the processor 535 can be used to trigger the analyte sensor system 308 to wake up, or cause it to end or terminate a lower power state . As mentioned above, the analyte sensor 808 can include a first terminal 828 and a second terminal 830. The detection circuit 802 can include a reference terminal 820 and an input terminal 822. The measurement device 810 can include a first terminal 824 and a second terminal 826 .

[0160] ​​As described above, the circuit 800 can be used to control the operation of the analyte sensor system 308. The detection circuit 802 can indicate whether the signal at the input terminal 822 meets one or more conditions. For example, the conditions can be one or more threshold voltage values that can be set using the reference voltage(s) 804 applied to the reference terminal(s) 820 of the detection circuit 802, or can include this one or more threshold voltage values. The voltage(s) at the input terminal(s) 822 can represent the current that can flow between the first terminal 828 and the second terminal 830 of the analyte sensor 808 (e.g., using the circuit elements of the circuit 800 including the capacitive element 834 to effectively convert the current through the analyte sensor 808 into a voltage). For example, the condition(s) can be threshold values that are programmable, adaptable, variable, and / or configurable, and can be used and / or can include this threshold value. In a particular example, the condition(s) are configured such that when the voltage(s) of the signal(s) provided at the input terminal 822 indicates the current that can flow between the first terminal 828 and the second terminal 830 of the analyte sensor 808 when the analyte sensor 808 is embedded in the host or under other conditions, the condition(s) can be achieved. In such a case, the output(s) 836 of the detection circuit 802 trigger the analyte sensor system 308 to exit a lower power state by indicating that this signal(s) at the input terminal 822 meets the condition(s) (e.g., depending on the level(s) of the output signal(s) 836).

[0161] In a specific example, the condition(s) are such that the voltage(s) of one or more signals provided at the input terminal 822, when the analyte sensor 808 is embedded in the host or under other conditions, indicates the current that can flow between the first terminal 828 and the second terminal 830 of the analyte sensor 808, and the condition(s) can be configured to be achieved. In such a case, the output(s) 836 of the detection circuit 802 trigger the analyte sensor system 308 to exit a lower power state by indicating that this signal(s) at the input terminal 822 meets the condition(s) (e.g., depending on the level(s) of the output signal(s) 836). ​​​​​​​​​​​It can be used to do so. For example, in some cases, the output(s) 836 of the detection circuit 802 may include a binary level, a number of discrete levels, and / or continuous or substantially continuous values or analog values that can be used to trigger the operation of the analyte sensor system 308 to one or more trigger states or active states. In some cases, the state to which the analyte sensor system 308 transitions may depend on the characteristics (e.g., level, trend, etc.) of the output 836. In an embodiment, as further discussed in connection with FIG. 8B, the condition(s) may be configured such that when a specific number of voltage pulses meet (e.g., reach or exceed) the threshold(s), or when a set of a specific number of voltage pulses exceeds the threshold(s), the condition(s) is / are achieved. As will be further considered in connection with FIG. 8B, in an embodiment, the condition(s) may be configured such that when a specific number of voltage pulses meet (e.g., reach or exceed) the threshold(s), or when a set of a specific number of voltage pulses exceeds the threshold(s), the condition(s) is / are achieved. set of a specific number of voltage pulses exceeds the threshold(s), the condition(s) is / are achieved. set of a specific number of voltage pulses exceeds the threshold(s), the condition(s) is / are achieved. set of a specific number of voltage pulses exceeds the threshold(s), the condition(s) is / are achieved.

[0162] The switch element 812 can be used to couple or decouple the first terminal 828 of the analyte sensor 808 to / from the first terminal 824 of the measurement device 810 (e.g., a potentiostat). The switch element 814 can be used to couple or decouple (optionally via the resistor element 832) the first terminal 828 of the analyte sensor 808 to / from the input terminal 822 of the detection circuit 802. The input terminal 822 of the detection circuit 802 can be coupled to the second terminal 830 of the analyte sensor 808 and the second terminal 826 of the measurement device 810. 826 of the measurement device 810. At a first point in time, the switch element 812 is closed or placed in a conducting state, and the first terminal 828 of the analyte sensor 808 is coupled to the first terminal 824

[0163] of the measurement device 810. of the measurement device 810. can be coupled to. The switch element 814 is open or in a high-impedance state at this point and can isolate the input terminal 822 of the detection circuit 802 from the first terminal 828 of the analyte sensor 808. Thus, at the first point in time, the measurement device 810 can be used in connection with collecting information that can be used to calculate the level of the analyte within the host . Further, using the circuit 800 (e.g., as mentioned above), in particular, the voltage waveform generated using the charging current that can flow through the capacitance of the analyte sensor 808 is supplied to terminal 82 2 and monitored using the detection circuit 802 (e.g., which can be or include amplifier elements and / or comparators or other circuits ) and compared with the reference voltage 804 .

[0164] At a second point in time, the switch element 812 is open or set to a high-impedance state, and thus can isolate the first terminal 828 of the analyte sensor 808 from the first terminal 824 of the measurement device 8 10. The switch element 814 is closed or set to a low-impedance or conductive state at this point and thus can couple the second terminal 830 of the analyte sensor 808 to the first terminal 828 of the analyte sensor 808 (optionally, in some cases, via the resistor element 832). This reduces or in some cases eliminates the potential existing across the analyte sensor 80 8 and uses the switching action of the driver 806 and the switch element 816 to at least substantially discharge the stored charge of the capacitance of the analyte sensor 808 (see, e.g., FIG. 7A ) to create a conductive path to the reference voltage 818 . As described, the resistor element 832 is connected to the switch element 814 and / or ). when 816 is closed or placed in a conductive or low impedance state can optionally be used to limit the current that can flow through switch elements 814 and / or 816 and can be used.

[0165] Capacitive element 834 can be coupled between the input terminal 822 of detection circuit 802 (shown here as being coupled to the second terminal 830 of analyte sensor 8 08) and the voltage reference 818 (e.g., ground). Switch element 816 can be driven by a signal from driver circuit 806 (e.g., a clock or other signal) or otherwise input and acquired, so switch element 816 can periodically couple the input terminal 822 of detection circuit 802 to reference 818. For example, if the reference voltage 818 is ground, this can at least substantially discharge capacitive element 834, as further mentioned / discussed in connection with FIG. 8B. As described, capacitive element 834 can be used in conjunction with driver circuit 806 and / or switch element 816 to implement a current-to-voltage circuit. The current-voltage circuit can convert the current that can flow through analyte sensor 808 into a voltage (e.g., a waveform) that can be measured or otherwise characterized using detection circuit 802 in connection with determining whether a threshold / condition has been achieved or satisfied, and is further related to operating and / or triggering analyte sensor system 308 to change state as described above. and can be operable to convert it into a voltage (e.g., a waveform) for use in determining whether a threshold / condition has been achieved or satisfied, and further related to operating and / or triggering analyte sensor system 308 to change state and can be operable to convert it into a voltage (e.g., a waveform) that can be measured or otherwise characterized using detection circuit 802.

[0166] In embodiments, switch elements 812 and 814 can be driven by a common signal that can be inverted with respect to either switch element 812 or switch element 814. Alternatively, switch elements 812 and 814 may be driven by a common signal, but the devices used for switches 812 and 814 may have opposite polarities. For example, in an embodiment, switch elements 812 and 814 are driven such that switch elements 812 and 814 are configured to be in opposite (e.g., impedance) states at a given time and may be. Thus, switch elements 812 and 814 are, for the most part, such that when switch element 812 is closed, switch element 814 will open, and vice versa and may be configured. When configured in this way, switch elements 812 and 814 are used to at least substantially discharge the capacitance associated with analyte sensor 808. Thus, the analyte sensor system 308 is operated to reproduce and use generally the first inrush current through the capacitance of analyte sensor 808 that may be normally associated with the implantation of analyte sensor 808 into the body of the host to end a lower power state, and / or to generate additional voltage pulses that may be monitored for the purpose of causing and / or making it do so. Thus, in situations where the current rush resulting from the implantation of analyte sensor 808 does not trigger operation, switch elements 812 and 814 can be used to substantially reset circuit 8 00 so that another monitorable current rush occurs and can trigger the operation of analyte sensor system 308. And

[0167] In addition to / Instead of this, in order to allow flexibility, adjustment, configuration, and / or optimization, the timing for controlling switch elements 812 and 814 to be in different states is The switch elements 812 and / or 814 can be placed in a specific state / mode according to various durations / intervals / frequencies / etc., and / or duty cycles, etc. and / or can be programmable, adaptable, variable, and / or configurable such that they can be placed in a specific state / mode according to various durations / intervals / frequencies / etc., and / or duty cycles, etc. This such timing control can be implemented using the driver circuit 806 and / or derived from the driver circuit 806, such that, for example, the states of the switch elements 812 and 814 change every given number of cycles of the driver circuit 806, and / or can be maintained for a selectable / controllable duration. Figure 8B shows an exemplary plot of a signal (e.g., voltage, current, etc.) of the analyte sensor 808 according to an embodiment of the present disclosure. The waveforms 870 and 880 can represent a signal (e.g., voltage, current, etc.) 840 as a function of time 842 (e.g., in seconds), and such a signal can be a signal that exists on the input terminal 822 of the detection circuit 802 within the circuit 800 (see, for example, Figure 8A) or can be supplied to the input terminal 822. The reference voltage 848 can be set such that when a voltage or other signal existing on the input terminal 822 of the detection circuit 802 reaches, exceeds, or crosses the reference voltage 848, the operation of the analyte sensor system 308 can be triggered using the output 836 of the detection circuit 802. As shown in Figure 8B, during the time between the end of the waveform 870 and the start of the waveform 880, the signal (e.g., voltage) on the input terminal 822 of the detection circuit 802 closes, among other things, the switch elements 814 and / or the switch element 816.

[0168] Figure 8B shows an exemplary plot of a signal (e.g., voltage, current, etc.) of the analyte sensor 808 according to an embodiment of the present disclosure. The waveforms 870 and 880 can represent a signal (e.g., voltage, current, etc.) 840 as a function of time 842 (e.g., in seconds), and such a signal can be a signal that exists on the input terminal 822 of the detection circuit 802 within the circuit 800 (see, for example, Figure 8A) or can be supplied to the input terminal 822. The reference voltage 848 can be set such that when a voltage or other signal existing on the input terminal 822 of the detection circuit 802 reaches, exceeds, or crosses the reference voltage 848, the operation of the analyte sensor system 308 can be triggered using the output 836 of the detection circuit 802. As shown in Figure 8B, during the time between the end of the waveform 870 and the start of the waveform 880, the signal (e.g., voltage) on the input terminal 822 of the detection circuit 802 closes, among other things, the switch elements 814 and / or the switch element 816. The reference voltage 848 can be set such that when a voltage or other signal existing on the input terminal 822 of the detection circuit 802 reaches, exceeds, or crosses the reference voltage 848, the operation of the analyte sensor system 308 can be triggered using the output 836 of the detection circuit 802. As shown in Figure 8B, during the time between the end of the waveform 870 and the start of the waveform 880, the signal (e.g., voltage) on the input terminal 822 of the detection circuit 802 closes, among other things, the switch elements 814 and / or the switch element 816. The reference voltage 848 can be set such that when a voltage or other signal existing on the input terminal 822 of the detection circuit 802 reaches, exceeds, or crosses the reference voltage 848, the operation of the analyte sensor system 308 can be triggered usin...

Claims

1. 1. A system for controlling operation of analyte sensor electronics, comprising: The analyte sensor electronics are electrically and mechanically coupled to the analyte sensor electronics prior to transitioning the system to an operational state. an analyte sensor coupled to the analyte sensor electronics comprising: triggering an indication for the system to exit a lower power state and transition to the operating state. and triggering the indication based on a threshold associated with a deployment of the system. Triggered by, triggering, In response to the indication, information related to a level of the analyte in the host is transmitted to the analyte sensor. generating a control signal operable to cause the generating a comparison between the information relating to the level of the analyte in the host and a condition; And and adapted to: The system detects when the indication is triggered and when the level of the analyte in the host is reached. and based on said comparison indicating that said level satisfies said condition, The system exits a power state and transitions to the operating mode.

2. triggering the system to trigger the indication in response to the threshold being satisfied for at least a predetermined time; 13. The method of claim 1, wherein the analyte sensor electronics is further adapted to trigger a system.

3. The indication comprises one of inserting the analyte sensor into the host and deploying the system. and an actuation detection circuit and an actuation detection component adapted to detect one or more of the actuation detection components. The system of claim 1 , wherein the signal is generated using one or more.

4. The control signal causes the potentiostat to apply a voltage bias to the analyte sensor. by providing the analyte sensor with a priori information related to the level of the analyte in the host.

10. The system of claim 1, wherein the information is a signal operable to collect the information.

5. After the system transitions to the operational state, the system continuing to collect said information related to said level of the object, and synthesizing said information into one or more The system of claim 1, further comprising: a display device or one or more partner devices. Tem.

6. 2. The method of claim 1, wherein the threshold value is related to a level of a known analyte normally present in a human host. The system described.

7. The indication is: a detected proximity between the analyte sensor electronics and a reference object; a temperature monitored using the analyte sensor electronics; and an accelerometer output of the analyte sensor electronics; and using wireless signaling transmitted or received by the analyte sensor electronics. The generated response, a detected change in air pressure measured by the analyte sensor electronics; and audio information monitored by the analyte sensor electronics; and a photon detector configured to detect a photon emitted by the analyte sensor electronics; a signal generated by the path; a conductivity measured between two terminals of the analyte sensor electronics; and A mechanical switch located on or within the housing of the analyte sensor electronics. Itchi and In response to the movement of the component, a conductive element of the analyte sensor electronics is A component adapted to modify the connection; The measured distortion; The system of claim 1 , wherein the image is generated using one or more of:

8. The system, upon determining that the level of the analyte in the host exceeds a threshold value, 2. The system of claim 1, wherein the system is operable to exit the lower power state by

9. The system responds to a condition being satisfied at a programmed time interval by displaying the indication.

2. The method of claim 1 , wherein the analyte sensor electronics is further adapted to trigger The system described.

10. Information related to the level of the analyte in the host is generated as a detected count. the condition includes a threshold characteristic of the count, and the comparison is used to If the output count indicates that the threshold has been reached, the system 2. The system of claim 1, wherein the system transitions to said operating mode upon exiting a power state that is not in a standby state.

11. 1. A method for controlling analyte sensor electronics, comprising: The analyte sensor electronics uses one or more of an analyte sensor and a secondary sensor. and obtaining a first signal generated by a first condition based on the first signal acquired by the analyte sensor electronics; is satisfied; and In response to the first condition being satisfied, the analyte sensor electronics activating an object measurement circuit; The analyte measurement circuit uses the analyte sensor to obtain information related to an analyte value in a host. and collecting analyte information before the analyte sensor is implanted in the host. a collecting device coupled to the object sensor electronics; The analyte sensor electronics detects whether the information related to the analyte value in the host is a second determining whether the condition of determining whether the information related to the analyte value in the host satisfies the second condition; In response to the analyte sensor electronics determining, the sensor electronics Exiting a power consuming mode, or If the information related to the analyte value in the host does not satisfy the second condition. In response to the analyte sensor electronics determining, the analyte sensor electronics and remaining in the lower power consumption mode and receiving a second signal indicating whether the first condition is met. and acquiring an electrical signal of A method comprising:

12. The information related to the analyte value is provided to the host when the level of the analyte value in the host exceeds a threshold value. The second condition is met if the second condition is met when the method.

13. 12. The method of claim 11, wherein the first condition represents a proximity of the analyte sensor electronics to a reference point. The method described.

14. 12. The method of claim 11, wherein the first condition represents a level of acceleration detected using an accelerometer. The method according to

15. The first condition is determined based on one or more electrical properties measured for the analyte sensor. Related method according to claim 11.

16. 1. A system for monitoring an analyte in a host, comprising: one or more sensors adapted to collect information relating to the level of the analyte in the host; an analyte sensor including a plurality of electrodes; The analyte sensor is mechanically and mechanically coupled to the host prior to implantation. electrically coupled to sensor electronics; Including, A first condition and an electrical signal passing between at least two of the one or more electrodes. and generating an indicator using a measurement of the signal. It is being The sensor electronics associates a second condition with the level of the analyte in the host. generating a confirmation of the indicator using the information; The system further includes a slave circuit adapted to transition the system to an active state. Tem.

17. The sensor electronics detects impedance, static electricity, and other characteristics associated with the one or more electrodes. determining one or more of a capacitance, a voltage, and a current; using said measurement of said electrical signal passing between said at least two of said electrodes.

20. The system of claim 16, further adapted to:

18. 1. A system for monitoring an analyte in a host, comprising: analyte sensor electronics; The analyte sensor electronics are mechanically and mechanically connected to the analyte sensor electronics before the analyte sensor is implanted in the host. and an analyte sensor electrically coupled to the information associated with the analyte sensor and related to the level of the analyte in the host; and adapted to generate a control signal operable to cause the analyte sensor to acquire an actuation detection circuit, the control signal being an electrical signal indicating that a first condition is met; an actuation detection circuit generated in response to the signal; Including, If the level of the analyte in the host satisfies a second condition, and and causing the system to change state if the signal indicates that the first condition is met. the analyte sensor electronics being adapted to

19. The indication is: a detected proximity between the analyte sensor electronics and a reference object; a temperature monitored by the analyte sensor electronics; and an accelerometer output of the analyte sensor electronics; and using wireless signaling transmitted or received by the analyte sensor electronics. The generated response, a detected change in air pressure measured by the analyte sensor electronics; and audio information monitored by the analyte sensor electronics; and a photon detector configured to detect a photon emitted by the analyte sensor electronics; a signal generated by the path; a conductivity measured between two terminals of the analyte sensor electronics; and A mechanical switch located on or within the housing of the analyte sensor electronics. Itchi and In response to the movement of the component, a conductive element of the analyte sensor electronics is A component adapted to modify the connection; The measured distortion; The system of claim 18, wherein the image is generated using one or more of:

20. 1. A system for monitoring an analyte in a host, comprising: analyte sensor electronics; The analyte sensor is coupled to the analyte sensor electronics prior to implantation in the host. and an analyte sensor adapted for a second sensor coupled to the analyte sensor and monitoring the second sensor according to a sampling frequency; and detecting a first event detected using the secondary sensor. an actuation detection circuit adapted to increase the ring frequency; Including, monitoring the secondary sensor according to the increased sampling frequency; generating a control signal in response to detecting a vent. A circuit is further adapted to, when the analyte sensor is implanted in the host, causing the analyte sensor to measure to obtain information indicative of a level of the analyte in the sample. The control signal is operable such that In response to the information indicative of the level of the analyte in the host satisfying a condition, and further in response to the actuation detection circuit detecting the second event. the analyte sensor electronics is further adapted to change a state in the system; There is a system.

21. The sampling frequency is determined by the first inductor component. and the second event is set according to one or more classifications of the first event and the second event.

21. The system described in 20.

22. 1. A circuit for controlling operation of an analyte sensor system, comprising: adapted to indicate whether a signal at an input terminal of the detection circuit meets a condition. and if the detection circuit indicates that the signal satisfies the condition, a lower power and a detection system further adapted to trigger the analyte system to terminate the state. The circuit, to control coupling between the input terminal of the detection circuit and a first terminal of the analyte sensor. a first switch element adapted to detect an analyte level in a host; a first switch element adapted to collect information related to the loop; The coupling between the first terminal of the analyte sensor and a first terminal of a potentiostat is a second switch element adapted to control a pre-selection of the analyte in the host; A voltage bias is applied to the analyte sensor, causing the analyte sensor to collect the information related to the level. a second switch element, the potentiostat adapted to apply to the sensor; and, Including, The input terminal of the detection circuit is connected to a second terminal of the analyte sensor and to the potential a second terminal of the theostat; The circuit connects the first terminal of the analyte sensor to the potentiostat at a first time. a first terminal of said detecting circuit and a second switching element of said detecting circuit. isolating the first switch element from the first terminal of the analyte sensor. and at a second time, connecting the first terminal of the analyte sensor to the front of the potentiostat. isolating the second switch element from the first terminal and the input terminal of the detection circuit; by coupling the first switch element to the first terminal of the analyte sensor. to generate an additional detectable event for actuating the analyte sensor system. The circuit is adapted to:

23. a capacitive element coupled between the input terminal of the detection circuit and a second reference voltage; 23. The circuit of claim 22, comprising:

24. The second switch element connects the input terminal of the detection circuit to the divider through a resistor element.

23. The circuit of claim 22 adapted to couple to the first terminal of a deposition sensor. 。

25. a third input terminal of the detection circuit adapted to couple the input terminal of the detection circuit to the second reference voltage; 23. The circuit of claim 22, further comprising a switch element.

26. The third switch element couples the input terminal of the detection circuit to the second reference voltage.

26. The circuit of claim 25, wherein the capacitive element then discharges.

27. A terminal of the third switch element connects the input terminal of the detection circuit to the second reference voltage 27. The method of claim 26, wherein the third switch element is coupled to a clock that periodically couples the third switch element to a The circuit described in

28. The first switch element is driven by a common signal, and the second switch element is 23. The circuit of claim 22, driven by an inverted version of the common signal.

29. the first switch element and the second switch element are driven by a common signal; 23. The circuit of claim 22 having opposite polarity.

30. When the analyte sensor is implanted in the host, a voltage is applied to the input terminal of the detection circuit. a voltage between the first terminal of the analyte sensor and the second terminal of the analyte sensor 23. The circuit of claim 22, wherein the circuit indicates a current between

31. A reference terminal of the detection circuit is coupled to a first reference voltage, and the detection circuit is 23. The circuit of claim 22, further comprising a transformer.

32. 23. The circuit of claim 22, wherein the second voltage reference is ground.

33. 1. An analyte sensor system comprising: an analyte sensor; During a first sampling state, a first potential is applied across the analyte sensor. So that, During a second sampling state, a second potential is applied across the analyte sensor. a state machine configured as follows: during the first sampling state based on application of the first potential, generating a first digital count corresponding to a first current through the capacitor; and during the second sampling state based on application of the second potential, a second digital count corresponding to a second current through the capacitor; A precipitate sensor measurement circuit; determining a first difference between the second digital count and the first digital count; ,and In response to at least the first difference satisfying a threshold, the controller a detection circuit configured to generate an equalization signal; At least the first sampling state, the second sampling state, and the transitioning to a lower power state for the duration of said determination of the first difference; In response to the controller wake-up signal, the controller wakes up from the lower power state to an operational state. transition to the determining an impedance of the analyte sensor based at least in part on the first difference; A controller configured to determine 1. An analyte sensor system comprising:

34. The state machine controls the analyte sensor during a first delay state immediately preceding a first sample state. a first potential applied across said first contact; The analyte sensor measurement circuitry stops generating a digital count during the first delay state.

34. The analyte sensor system of claim 33, configured to:

35. The state machine controls the analyte sensor during a second delay state immediately preceding a second sample state. and configured to cause initiation of the second potential applied across the resistor; The analyte sensor circuitry suspends generating a digital count during the second delay state.

35. The analyte sensor system of claim 34 configured to:

36. The state machine continues the division during a third delay state following the second sampling state. configured to apply zero potential across the deposition sensor; The analyte sensor measurement circuitry stops generating a digital count during the third delay state.

36. The analyte sensor system of claim 35, configured to:

37. The detection circuit includes a first sample configured to store the first digital count.

34. The analyte sensor system of claim 33 comprising a pull buffer.

38. The detection circuit, receiving the first digital count from the first sample buffer; receiving the second digital count from the analyte sensor measurement circuit; and 38. The analysis of claim 37, comprising a differentiator configured to determine the first difference. Object sensor system.

39. The detection circuitry detects the first difference and at least a third digital count and a fourth digital count. a integrator configured to generate a sum of a second difference between the third count and the second count; A digital count of the analyte sensor is generated during a subsequent phase of the first sampling state. the fourth digital count corresponds to a third current through the second sampling 34. The method of claim 33, wherein the second current corresponds to a fourth current passing through the analyte sensor during a subsequent stage of a blocking state. The analyte sensor system according to claim 1,

40. The detection circuitry detects whether the sum of at least the first difference and the second difference is greater than or equal to the threshold value. generating a wake-up signal for the controller in response to the 40. The analyte sensor system of claim 39 configured

41. The controller may further include at least one of the first and second power states.

34. The analyte sensor of claim 33, configured to define one parameter. Stem.

42. In a first mode of operation of the analyte sensor system, the first potential is zero volts. the second potential being greater than the first potential by a predetermined amount; In a second mode of operation of the analyte sensor system, the first potential is the potential applied across the analyte sensor to determine the analyte concentration, 34. The assay of claim 33, wherein the second potential is greater than the first potential by the predetermined amount. Object sensor system.

43. 1. A method for controlling an analyte sensor system, comprising: Using a state machine, During a first sampling state, a first potential is applied across the analyte sensor. And During a second sampling state, a second potential is applied across the analyte sensor. And to do so, Utilizing the analyte sensor measurement circuitry, during the first sampling state based on application of the first potential, generating a first digital count corresponding to a first current through the capacitor; and during the second sampling state based on application of the second potential, generating a second digital count corresponding to a second current through the resistor; Using a detection circuit, determining a first difference between the second digital count and the first digital count; ,and In response to at least the first difference satisfying a threshold, the controller generating an equalization signal; In the controller, At least the first sampling state, the second sampling state, and the transitioning to a lower power state for the duration of said determination of the first difference; In response to the controller wake-up signal, the controller wakes up from the lower power state to an operational state. transition to the determining an impedance of the analyte sensor based at least in part on the first difference; and determining whether A method comprising:

44. across the analyte sensor during a first delay state immediately preceding the first sample state. commencing application of the first potential; generating a digital count by the analyte sensor measurement circuit during the first delay state; To interrupt and 44. The method of claim 43, further comprising:

45. across the analyte sensor during a second delay state immediately preceding the second sample state. commencing application of the second potential; generating a digital count by the analyte sensor measurement circuit during the second delay state; 45. The method of claim 44, further comprising: interrupting.

46. Utilizing the state machine to sample the previous sample during a third delay state following the second sample state. causing a zero potential to be applied across the analyte sensor; generating a digital count by the analyte sensor measurement circuit during the third delay state; 46. ​​The method of claim 45, further comprising: interrupting.

47. Prior to determining the first difference, the first digital count is sampled in a first sample buffer.

44. The method of claim 43, further comprising storing the information in a

48. receiving the first digital count from the first sample buffer by a differentiator; To do, The differentiator receives the second digital count from the analyte sensor measurement circuit. To believe and utilizing the differentiator to determine the first difference; 48. The method of claim 47, further comprising:

49. Utilizing an integrator, the first difference and at least a third digital count and a fourth digital count are multiplied. generating a sum of second differences between the third digital count and the second digital count; Counts flow through the analyte sensor during a subsequent phase of the first sampling state. corresponding to a third current, the fourth digital count being 44. The method of claim 43, wherein the step corresponds to a fourth current passing through the analyte sensor during a subsequent step. Law.

50. the sum of at least the first difference and the second difference satisfies the threshold value; generating the controller wake-up signal in response to 49. The method according to claim 49.

51. The controller is utilized to program the state machine prior to transitioning to the lower power state.

44. The method of claim 43, further comprising defining at least one parameter.

52. In a first mode of operation of the analyte sensor system, the first potential is zero volts. the second potential being greater than the first potential by a predetermined amount; In a second mode of operation of the analyte sensor system, the first potential is the potential applied across the analyte sensor to determine the analyte concentration, 44. The method of claim 43, wherein the second potential is greater than the first potential by the predetermined amount. 。

53. 1. A system for controlling operation of analyte sensor electronics, comprising: an analyte sensor; A wake signal is triggered in response to a magnet being brought sufficiently close to the magnetic sensor. A magnetic sensor configured as above. in response to the wake signal, exiting a lower power state and transitioning to an operating state; and In response to the transition to the operating state, one or more analyte concentrations are detected from the analyte sensor. an analyte sensor electronics configured to receive an indication of the value; Including, the system.

54. The magnet is connected to a display device configured to display the one or more analyte concentration values.

54. The system of claim 53, wherein the system is disposed on a substrate.

55. The magnetic sensor detects a predetermined motion and a predetermined spatial orientation of the magnet relative to the magnetic sensor. and triggering said wake signal in response to being moved by at least one of said first and second inputs.

54. The system of claim 53,

56. 1. A display device configured to display one or more analyte concentration values, comprising: One or more of the sounds emitted by the applicator during deployment of the analyte sensor system. a microphone configured to generate an audio waveform of While the applicator is deploying the analyte sensor system, a processor configured to execute the application, Analyzing the one or more audio waveforms; and detecting an analyte in the analyte sensor system based on the analyzing the one or more audio waveforms; A deployment manager configured to identify successful or unsuccessful deployments of a system. Sessa and A first successful deployment in response to the application identifying the successful deployment. and a failed deployment in response to the application identifying the failed deployment. a display configured to display at least one of the first and second representations of the deployment; 、 a display device.

57. The analyzing of the one or more audio waveforms includes: of the one or more audio waveforms indicating that the portion performs a known movement of the successful deployment.

57. The display device of claim 56, further comprising identifying at least a portion.

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