Sterilizing composition

Abstract

To provide a sterilizing composition which exhibits enhanced duration of sterilizing effects on the skin surface as compared with the prior art.SOLUTION: A sterilizing composition comprises (A) a cationic sterilizing agent, (B) a cationic polymer, and (C) a chelating agent.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a sterilizing composition.

Background Art

[0002] Conventionally, it has been known that bactericides are effective for sterilizing and bacteriostatic action of microorganisms on the skin surface, and today they are used in various forms such as cosmetics, pharmaceutical compositions, and oral compositions. On the other hand, when applying a bactericide to the skin surface, there is a problem that the components of the bactericide may flow away without remaining on the skin surface due to sweating or the like after application, and a sufficient bactericidal effect may not be sustained on the skin surface.

[0003] In order to improve the persistence of the bactericidal effect of such bactericides applied to the skin surface, for example, Patent Document 1 reports a technique for forming a complex of a bactericide and a water-swellable clay mineral. Further, Patent Document 2 reports a technique for improving the infection prevention effect against bacteria and viruses by combining one or more acids selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid or salts thereof with an acid or a salt thereof having a predetermined pKa.

[0004] However, in the prior art, the actual situation is that it cannot be said to be sufficient in terms of the retention of the active ingredient of the bactericide on the skin surface and the accompanying persistence of the bactericidal effect.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0006] Under such circumstances, it has been an ongoing technical challenge to provide a sterilizing composition with improved persistence of the sterilizing effect on the skin surface as compared to the prior art.

[0007] Accordingly, an object of the present invention is to provide a sterilizing composition with improved persistence of the sterilizing effect on the skin surface as compared to the prior art. Another object of the present invention is to provide a method for producing a sterilizing composition with improved persistence of the sterilizing effect on the skin surface as compared to the prior art. [Means for Solving the Problems]

[0008] As a result of intensive research, the present inventors have found that the above-described problems can be solved by blending (A) a cationic bactericide, (B) a cationic polymer, and (C) a chelating agent in a sterilizing composition. The present invention is based on such findings.

[0009] That is, according to the present invention, the following inventions are provided. [1] A sterilizing composition containing (A) a cationic bactericide, (B) a cationic polymer, and (C) a chelating agent . [2] The sterilizing composition according to [1], wherein the (A) cationic bactericide contains at least one of benzalkonium chloride and cetylpyridinium chloride. [3] The sterilizing composition according to [1] or [2], wherein the (B) is a cationic homopolymer. [4] The sterilizing composition according to any one of [1] to [3], wherein the cationic homopolymer contains at least one of polylysine and polydimethyldimethylenepyrrolidinium chloride. [5] The sterilizing composition according to any one of [1] to [4], wherein the (C) contains at least one selected from the group consisting of diethylenetriaminepentaacetic acid, edetic acid, hydroxyethanediphosphonic acid, citric acid, metaphosphoric acid, polyphosphoric acid, phytic acid, and salts thereof. [6] The content of the cationic bactericide (A) is 0.0003 to 10% by mass based on the total mass of the bactericidal composition, and the bactericidal composition according to any one of [1] to [5]. [7] The content of the cationic polymer (B) is 0.001 to 30% by mass based on the total mass of the bactericidal composition, and the bactericidal composition according to any one of [1] to [6]. [8] The content of the chelating agent (C) is 0.001 to 30% by mass based on the total mass of the bactericidal composition, and the bactericidal composition according to any one of [1] to [7]. [9] The bactericidal composition according to any one of [1] to [8], which is for skin, oral cavity or hair.

[10] The bactericidal composition according to any one of [1] to [9], which is for sustained bactericidal action.

[11] The bactericidal composition according to any one of [1] to

[10] , which is a cosmetic, pharmaceutical composition or oral composition.

[12] The bactericidal composition according to any one of [1] to

[11] , which is an antiperspirant, axillary osmidrosis preventive, external skin preparation, finger disinfectant, skin cleanser or hair cosmetic. [Advantages of the Invention]

[0010] According to the present invention, in the bactericidal composition, it is possible to improve the persistence of the bactericidal effect on the skin surface as compared with the prior art. [Modes for Carrying Out the Invention]

[0011] [Bactericidal Composition] According to one aspect of the present invention, there is provided a bactericidal composition (hereinafter, also referred to as "the bactericidal composition of the present invention") having improved persistence of the bactericidal effect on the skin surface as compared with the prior art. The bactericidal composition of the present invention contains (A) a cationic bactericide, (B) a cationic polymer, and (C) a chelating agent as essential components. Hereinafter, each component will be described in detail.

[0012] (A) Cationic Bactericide The bactericidal composition of the present invention contains a cationic bactericide as an essential component. By containing a cationic bactericide, the bactericidal composition exhibits a bactericidal effect on the skin surface, oral cavity, hair, etc. The cationic bactericide that can be used in the present invention is not particularly limited as long as the effects of the present invention are achieved, and examples thereof include quaternary ammonium salts, biguanide-based bactericides, and the like.

[0013] Examples of quaternary ammonium salts include benzalkonium chloride, cetylpyridinium chloride, benzethonium chloride, decalinium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, lauryltrimethylammonium chloride, laurylpyridinium chloride, and the like.

[0014] Examples of biguanide-based bactericides include alexidine gluconate, alexidine hydrochloride, alexidine acetate, chlorhexidine hydrochloride, chlorhexidine acetate, chlorhexidine hydrochloride, chlorhexidine gluconate, and the like.

[0015] The cationic bactericide may be used alone or in combination of two or more. The cationic bactericide is preferably a quaternary ammonium salt, more preferably benzalkonium chloride, cetylpyridinium chloride, benzethonium chloride, decalinium chloride, chlorhexidine hydrochloride, and particularly preferably benzalkonium chloride and cetylpyridinium chloride.

[0016] The content of the cationic bactericide in the bactericidal composition of the present invention is not particularly limited as long as the effects of the present invention can be achieved. However, based on the total mass of the bactericidal composition of the present invention, it is preferably 0.0003 to 10% by mass, more preferably 0.003 to 1% by mass, and particularly preferably 0.03 to 0.1% by mass. When the content of the cationic bactericide is 0.0003% by mass or more, sufficient bactericidal ability can be imparted to the bactericidal composition. On the other hand, when the content of the cationic bactericide is 10% by mass or less, the usability of the bactericidal composition and the stability of the formulation can be further improved.

[0017] (B) Cationic polymer The bactericidal composition of the present invention contains a cationic polymer as an essential component. By containing a cationic polymer in the bactericidal composition, the persistence of the bactericidal effect can be improved. In this specification, the cationic polymer means a compound having two or more kinds of monomers having a cationic hydrophilic group (that is, cationized when dissolved in water) as constituent units.

[0018] The cationic polymer that can be used in the present invention is not particularly limited as long as the effects of the present invention can be achieved. For example, cationic polypeptides, cationic polysaccharides, cationized hydroxyalkylcellulose, quaternized dialkylaminoalkyl (meth) acrylate polymers, diallyl quaternized ammonium salt polymers, methacrylamide propyltrimethylammonium salt polymers, methacryloyl ethyltrimethylammonium salt polymers, etc. can be mentioned.

[0019] Examples of the cationic polypeptide include polylysine (ε-polylysine, poly-ε-lysine), polyhistidine, polyarginine, polyornithine, etc.

[0020] Examples of the cationic polysaccharide include chitosan (including chitosan oligosaccharide and degraded chitosan), chitin, etc.

[0021] Examples of the cationized hydroxyalkyl cellulose include cationized hydroxyethyl cellulose, cationized hydroxypropyl cellulose, and the like. Examples of the cationized hydroxyethyl cellulose include o-[2-hydroxy-3-(trimethylammonio)propyl] hydroxyethyl cellulose chloride (Polyquaternium-10), and the like.

[0022] Examples of the quaternized dialkylaminoalkyl (meth)acrylate polymer include vinylpyrrolidone·diethyl sulfate dimethylaminoethyl methacrylate copolymer (Polyquaternium-11), diethyl sulfate dimethylaminoethyl methacrylate·N,N-dimethylacrylamide·diethylene glycol dimethacrylate copolymer (Polyquaternium-52), and the like.

[0023] Examples of the diallyl quaternized ammonium salt polymer include polydimethyl dimethylene pyrrolidinium chloride (polydimethyl dimethylene piperidinium chloride, dimethyldiallylammonium chloride polymer, Polyquaternium-6), dimethyldiallylammonium chloride·acrylic acid copolymer (Polyquaternium-22), diallyldimethylammonium chloride·acrylamide copolymer (Polyquaternium-7), acrylamide·acrylic acid·dimethyldiallylammonium chloride copolymer (Polyquaternium-39), and the like.

[0024] Examples of the methacrylamidopropyltrimethylammonium salt polymer include methacrylamidopropyltrimethylammonium chloride polymer, vinylpyrrolidone·methacrylamidopropyltrimethylammonium chloride copolymer, acrylic acid·methyl acrylate·methacrylamidopropyltrimethylammonium chloride copolymer (Polyquaternium-47), acrylic acid·acrylamide·methacrylamidopropyltrimethylammonium chloride copolymer (Polyquaternium-53), and the like.

[0025] Examples of the methacryloylethyltrimethylammonium salt polymer include methacryloylethyltrimethylammonium chloride polymer (polyquaternium-37), methacryloylethyldimethylbetaine·methacryloylethyltrimethylammonium chloride·methacrylic acid methoxypolyethylene glycol copolymer (polyquaternium-49), methacryloylethyldimethylbetaine·methacryloylethyltrimethylammonium chloride·2-hydroxyethyl methacrylate copolymer (polyquaternium-48), and the like.

[0026] Cationic polymers are classified into cationic homopolymers formed from the polymerization of one type of the same monomer and cationic heteropolymers formed from the polymerization of two or more different monomers. The cationic polymer preferably contains a cationic homopolymer.

[0027] Examples of the cationic homopolymer include polylysine (ε-polylysine, poly-ε-lysine), polyhistidine, polyarginine, polyornithine, chitosan (including chitosan oligosaccharide and degraded chitosan), chitin, polydimethyldimethylenepyrrolidinium chloride (polydimethyldimethylenepiperidinium chloride, dimethyldiallylammonium chloride polymer, polyquaternium-6), methacrylamidopropyltrimethylammonium chloride polymer, methacryloylethyltrimethylammonium chloride polymer (polyquaternium-37), and the like.

[0028] Examples of cationic heteropolymers include cationized hydroxyethyl cellulose, cationized hydroxypropyl cellulose, o-[2-hydroxy-3-(trimethylammonio)propyl] hydroxyethyl cellulose chloride (polyquaternium-10), vinyl pyrrolidone·N,N-dimethylaminoethyl methacrylate diethyl sulfate copolymer (polyquaternium-11), N,N-dimethylaminoethyl methacrylate diethyl sulfate·N,N-dimethylacrylamide· polyethylene glycol dimethacrylate copolymer (polyquaternium-52), dimethyldiallylammonium chloride·acrylic acid copolymer (polyquaternium-22), diallyldimethylammonium chloride·acrylamide copolymer (polyquaternium-7), acrylamide·acrylic acid·dimethyldiallylammonium chloride copolymer (polyquaternium-39), vinyl pyrrolidone·methacrylamidepropyltrimethylammonium chloride copolymer, acrylic acid·methyl acrylate·methacrylamidepropyltrimethylammonium chloride copolymer (polyquaternium-47), acrylic acid·acrylamide·methacrylamidepropyltrimethylammonium chloride copolymer (polyquaternium-53), methacryloyloxyethyl dimethyl betaine·methacryloyloxyethyl trimethylammonium chloride·methacrylic acid methoxypolyethylene glycol copolymer (polyquaternium-49), methacryloyloxyethyl dimethyl betaine·methacryloyloxyethyl trimethylammonium chloride·2-hydroxyethyl methacrylate copolymer (polyquaternium-48), etc.

[0029] The cationic polymer may be used alone or in combination of two or more. The cationic polymer preferably contains polylysine or polydimethyldimethylenepyrrolidinium chloride.

[0030] The content of the cationic polymer in the sterilizing composition of the present invention is not particularly limited as long as the effects of the present invention are achieved. However, based on the total mass of the sterilizing composition of the present invention, it is preferably 0.001 to 30% by mass, more preferably 0.0025 to 10% by mass, and particularly preferably 0.005 to 1% by mass. When the content of the cationic polymer is 0.001% by mass or more, the persistence of the sterilizing effect of the sterilizing composition can be sufficiently improved. On the other hand, when the content of the cationic polymer is 30% by mass or less, the sterilizing composition can be stably formulated, and the feel of use of the sterilizing composition can be made good.

[0031] (C) Chelating agent The sterilizing composition of the present invention contains a chelating agent as an essential component. By containing a chelating agent in the sterilizing composition, the persistence of the sterilizing effect by the above-mentioned (B) cationic polymer can be assisted, and the persistence of the sterilizing effect can be further improved. The chelating agent that can be used in the present invention is not particularly limited as long as the effects of the present invention are achieved. For example, phosphoric acid, phosphonic acid, aminocarboxylic acid, oxycarboxylic acid, dicarboxylic acid, their salts (e.g., sodium, potassium, magnesium, calcium, strontium, lithium, aluminum, copper, zinc, iron salts, etc.), hydrates (hydrated salts), etc. can be mentioned.

[0032] Examples of phosphoric acid or its salts include pyrophosphoric acid or its salts, polyphosphoric acid or its salts, metaphosphoric acid or its salts, phytic acid or its salts, etc. More specifically, sodium metaphosphate, sodium polyphosphate, phytic acid can be mentioned.

[0033] Examples of phosphonic acid or its salts include hydroxyethanediphosphonic acid (etidronic acid) or its salts, aminotrimethylenephosphonic acid or its salts, ethylenediaminetetramethylenephosphonic acid or its salts, phosphonobutanetricarboxylic acid or its salts, etc. More specifically, hydroxyethanediphosphonic acid can be mentioned.

[0034] Examples of the aminocarboxylic acid or its salt include, for example, edetic acid (EDTA) or its salt, nitrilotriacetic acid (NTA) or its salt, hydroxyethyliminodiacetic acid (HIDA) or its salt, trisodium 3-hydroxy-2,2'-iminodisuccinate (HIDS) or its salt, diethylenetriaminepentaacetic acid (DPTA) or its salt, hydroxyethylethylenediaminetriacetic acid (HEDTA) or its salt, dihydroxyethylglycine (DHEG) or its salt, L-glutamic acid diacetic acid (GLDA) or its salt, methylglycine diacetic acid (MGDA), aspartic acid or its salt, glutamic acid or its salt, and the like. More specifically, examples include pentasodium diethylenetriaminepentaacetate and disodium edetate.

[0035] Examples of the oxycarboxylic acid or its salt include, for example, citric acid or its salt, malic acid or its salt, tartaric acid or its salt, gluconic acid or its salt, lactic acid or its salt, mandelic acid or its salt, glycolic acid or its salt, oxalic acid or its salt, maleic acid or its salt, malonic acid or its salt, succinic acid or its salt, pantothenic acid or its salt, and the like. More specifically, an example includes sodium citrate.

[0036] Examples of the dicarboxylic acid or its salt include, for example, phthalic acid or its salt, fumaric acid or its salt, and the like.

[0037] The chelating agent may be used alone or in combination of two or more. The chelating agent preferably contains sodium metaphosphate, sodium polyphosphate, phytic acid, hydroxyethane diphosphonic acid, pentasodium diethylenetriaminepentaacetate, disodium edetate, and sodium citrate.

[0038] The content of the chelating agent in the sterilizing composition of the present invention is not particularly limited as long as the effects of the present invention are achieved. However, based on the total mass of the sterilizing composition of the present invention, it is preferably 0.001 to 30% by mass, more preferably 0.01 to 10% by mass, and particularly preferably 0.05 to 1% by mass. When the content of the chelating agent is 0.001% by mass or more, the persistence of the sterilizing effect by the (B) cationic polymer can be sufficiently improved. On the other hand, when the content of the chelating agent is 30% by mass or less, the sterilizing composition can be stably formulated, and the usability of the sterilizing composition can be made good.

[0039] The sterilizing composition of the present invention preferably contains each of the above-mentioned components (A) to (C) in specific ratios. Specifically, when the content of the component (A) is 1 part by mass, the content of the component (B) is, for example, 0.0001 part by mass to 100,000 parts by mass, preferably 0.0025 part by mass to 3333.33 parts by mass, and more preferably 0.05 part by mass to 33.33 parts by mass. Further, when the content of the component (A) is 1 part by mass, the content of the component (C) is, for example, 0.0001 part by mass to 100,000 parts by mass, preferably 0.01 part by mass to 3333.33 parts by mass, and more preferably 0.5 part by mass to 33.33 parts by mass. Further, when the content of the component (C) is 1 part by mass, the content of the component (B) is, for example, 0.000033 part by mass to 30,000 parts by mass, preferably 0.00025 part by mass to 1000 parts by mass, and more preferably 0.005 part by mass to 20 parts by mass.

[0040] The sterilizing composition of the present invention exhibits an equally improved persistence of the sterilizing effect not only on the skin surface but also on other parts similar to the skin, such as the oral cavity, mucous membranes, hair, etc. Further, as described above, since the sterilizing composition of the present invention can be applied to the skin and the like, it can also be used as a cosmetic, a pharmaceutical composition, an oral composition, etc. having a sterilizing effect.

[0041] The form of the sterilizing composition of the present invention is not particularly limited as long as the effects of the present invention are achieved. As cosmetics, for example, antiperspirants, bromhidrosis preventives, deodorants, anti-odor agents, external skin preparations, acne preventives, finger disinfectants, hand soaps, skin cleansers, scrub agents, body shampoos, body soaps, facial cleansing foams, cleansing foams, makeup removers, soaps, hair cosmetics, hair shampoos, hair rinses, hair conditioners, hair treatments (including those not to be rinsed off), hair styling agents, dandruff preventives, etc. can be mentioned. As pharmaceutical compositions, for example, antibacterial agents, antifungal agents, antimycotic agents, bactericides, bacteriostatic agents, etc. can be mentioned. Further, as oral compositions, for example, dentifrices, gel dentifrices, liquid dentifrices, mouthwashes, oral moisturizers, etc. can be mentioned.

[0042] The dosage form of the sterilizing composition of the present invention is not particularly limited as long as the effects of the present invention are achieved, and it can be solid or liquid. For example, it can be made into dosage forms such as ointments, pastes, pastes (mud pastes), gels, liquids, sprays, gums, tablets, etc.

[0043] (D) Other components The sterilizing composition of the present invention may contain other components that can be formulated in the sterilizing composition within the range where the effects of the present invention are achieved. Examples of other components include antioxidants, mineral / synthetic oils, animal / vegetable oils, waxes, fatty acids, alcohols, silicone oils, surfactants, abrasives, thickeners, wetting agents, high molecular compounds, animal / plant extracts, amino acids, sweeteners, fragrances, cooling agents, solvents, anti-inflammatory agents, preservatives, ultraviolet ray preventives, sequestering agents, antioxidants, pigments, pH adjusters, colorants, flavoring components, antiperspirant components, functional components, etc. The other components may be used alone or in combination of two or more.

[0044] Examples of antioxidants include vitamin E and its derivatives (e.g., tocopherols and their derivatives such as dl-α(β,γ)-tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl-α-tocopherol, linoleic acid-dl-α-tocopherol, dl-α-tocopherol succinate, etc., ubiquinones, etc.), vitamin A and its derivatives (e.g., retinols and their derivatives such as retinol palmitate, retinol acetate, etc., retinal and its derivatives such as dehydroretinal, etc.), carotenoids (e.g., carotene, lycopene, astaxanthin, etc.), vitamin B and its derivatives (e.g., thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinic acid benzyl, cholines, etc.), vitamin C and its derivatives (e.g., L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphate esters, L-ascorbic acid sulfate esters, etc.), vitamin D and its derivatives (e.g., ergocalciferol, cholecalciferol, dihydroxystanol, etc.), rutin and its derivatives, thiotaurine, taurine, hydroquinone and its derivatives, histidine, catechin and its derivatives, glabridin, glabrene, glycyrrhizin, isoglycyrrhizin, and licorice extracts containing these substances, etc.

[0045] Examples of mineral and synthetic oils include liquid paraffin, liquid isoparaffin, petrolatum, paraffin, ceresin, microcrystalline wax, α-olefin oligomer, polyethylene, polybutene, synthetic squalane, etc.

[0046] Examples of animal and vegetable oils include squalane, olive oil, olive oil, camellia oil, wheat germ oil, jojoba oil, avocado oil, carrot oil, shea butter, liquid shea butter, palm oil, palm kernel oil, hydrogenated oil, horse oil, lanolins, egg yolk oil, clove oil, rose hip oil, lavender oil, peppermint oil, spearmint oil, rosemary oil, macadamia nut oil, almond oil, safflower oil, safflower oil (2), sunflower oil, sunflower oil (2), medu home oil, almond oil, perilla oil, sesame oil, borage oil, cocoa butter, rice bran oil, rice germ oil, wikyo oil, orange oil, chamomile oil, cucumber oil, kukui nut oil, soybean oil, tea tree oil, corn oil, rapeseed oil, peppermint oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, argania spinosa kernel oil, cranberry baccinica seed oil, almond oil, peach kernel oil, grape seed oil, emu oil, mink oil, asa seed oil, linseed oil, sasanqua oil, candelilla wax, coconut oil, evening primrose oil, pistachio seed oil, mango butter, etc.

[0047] Examples of waxes include jojoba oil, beeswax, carnauba wax, rice bran wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac, orange raffia oil, etc.

[0048] Examples of fatty acids include natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, behenic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, lanolin fatty acid, and synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, isopentanoic acid, etc.

[0049] Examples of the alcohol include ethanol, isopropanol, butyl alcohol, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, hexyl decanol, behenyl alcohol, octyldodecanol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol, 2-octyldodecanol, batyl alcohol, and the like.

[0050] Examples of the silicone oil include methylpolysiloxane, methylphenylpolysiloxane, silicone resin, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, cyclic silicone resin, octamethyltrisiloxane, tetradecamethylhexasiloxane, highly polymerized methylpolysiloxane, trimethylsiloxysilicic acid, poly(oxyethylene·oxypropylene)methylpolysiloxane copolymer, poly(oxyethylene·oxypropylene)·butylene·methylpolysiloxane copolymer, polyoxyethylene·methylpolysilicic acid copolymer, polyoxypropylene·methylpolysiloxane copolymer, dimethylsiloxane·methylcetyloxysiloxane copolymer, dimethylsiloxane·methylstearoxysiloxane copolymer, and the like.

[0051] Examples of surfactants include lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzenesulfonate, sodium lauryl sulfacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, sucrose fatty acid ester, alkyl sulfate, polyoxyethylene alkyl sulfate, tetradecene sulfonate, polyoxyethylene alkyl sulfosuccinate, lauroyl sarcosine salt, alkyl methyl-β-alanine salt, polyoxyethylene alkyl ether phosphate, fatty acid soap, N-acyl glutamate, lauric acid diethanolamide, coconut fatty acid diethanolamide, alkyldimethylamine oxide, alkyl methyl taurine salt, alkyl aminopropionate, polyoxyethylene alkyl ether carboxylate, alkyl phosphate, alkyl glucoside, polyether-modified silicone, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, amidoamine, dialkyldimethylammonium chloride dimethylacetate betaine, alkylamidopropyl betaine, alkyl carboxymethyl hydroxyethyl imidazolinium betaine, lecithin (e.g., lecithin derived from soybeans or egg yolks, etc.) and its derivatives, propylene glycol fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, alkyl glycosides, sorbitan fatty acid ester, glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, lauryl ethanolamide, sodium cocoyl sarcosinate, sodium N-lauroyl methyl taurine solution, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl nonylphenyl ether, polyoxyethylene alkyl ether phosphate·phosphate, etc.

[0052] Examples of the abrasive include calcium carbonate, calcium phosphate, dicalcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, hydrous silicic acid, anhydrous silicic acid, titanium dioxide, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, resin, and the like.

[0053] Examples of the thickener include cellulose derivatives such as carrageenan, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, tragacanth gum, gum arabic, synthetic thickeners such as polyvinyl alcohol, sodium polyacrylate, polyvinyl pyrrolidone, and inorganic thickeners such as silica gel, aluminum silica gel, and veegum.

[0054] Examples of the wetting agent include glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, polyethylene glycol, 1,2-pentanediol, 1,3-hexanediol, propylene glycol, dipropylene glycol, isopropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, maltitol, reduced starch syrup, lactitol, palatinite, erythritol, sorbitol, mannitol, xylitol, xylose, trehalose, glycoside trehalose, glucose, glucose, lactose, mannose, maltose, fructose, inositol, pentaerythritol, maltotriose, starch hydrolysate, starch hydrolysate reduced alcohol, ethylene oxide, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, propylene oxide, water-soluble proteoglycan, collagen, ceramide, and the like.

[0055] Examples of the high molecular compounds include sodium alginate, carrageenan, agar, farselan, guar gum, quince seed, konjac mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, gum arabic, gatti gum, karaya gum, tragacanth gum, arabinogalactan, pectin, quince, wheat protein, soy protein, albumin, casein, gelatin, chitosan, hyaluronic acid, curdlan, xanthan gum, gellan gum, cyclodextrin, dextran, pullulan, crystalline cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, cationized cellulose, cationized guar gum, hydroxypropylated guar gum, carboxyvinyl polymer, polyacrylamide, sodium polyacrylate, highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, and the like.

[0056] Examples of the animal and plant extracts include placenta extract, hydrolyzed keratin, hydrolyzed silk, yeast extract, aloe extract, comfrey extract, peony extract, perilla extract, sage extract, assembly extract, witch hazel water, hickory extract, hop extract, mulberry extract, peach leaf extract, snowdrop extract, lemon balm extract, mugwort extract, rosemary extract, rice bran fermented extract, and the like.

[0057] Examples of the amino acids include L-alanine, L-arginine, L-aspartic acid, L-glutamine, L-asparagine, L-cysteine, L-serine, L-tyrosine, L-proline, pyrrolidone carboxylate, glycine, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, cystine, hydroxyproline, hydroxylysine, ornithine, histidine, γ-aminobutyric acid, ε-aminocaproic acid, and the like.

[0058] Examples of sweeteners include, for example, palatinite, aspartame, sodium saccharin, acesulfame potassium, stevioside, neohesperidin dihydrochalcone, glycyrrhizin, perillamine, thaumatin, aspartylphenylalanyl methyl ester, ρ-methoxycinnamic aldehyde, sucralose, xylitol, stevia, etc.

[0059] Examples of fragrances include, for example, compound fragrances such as strawberry flavor and apple flavor, terpene-based essential oils, phenylpropanoid-based essential oils, etc.

[0060] Examples of cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide, ethyl 3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthane carboxamide, etc.

[0061] Examples of solvents include, for example, organic solvents such as ethanol, propyl alcohol, isopropyl alcohol, purified water, tap water, etc.

[0062] Examples of anti-inflammatory agents include, for example, glycyrrhizic acid, dipotassium glycyrrhizate, monoammonium glycyrrhizate, glycyrrhetinic acid, stearyl glycyrrhetinate, guaiazulene, sodium guaiazulene sulfonate, allantoin, ε-aminocaproic acid, tranexamic acid, etc.

[0063] Examples of preservatives include, for example, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isobutyl paraben, phenoxyethanol, bisabolol, hinokitiol, paraoxybenzoic acid esters, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, sorbic acid, potassium sorbate, undecylenic acid, pionin, l-menthol, d-camphor, isopropylmethylphenol, benzethonium chloride, phenoxyethanol, alkyldiaminoethyl glycine hydrochloride, ethylhexylglycerin, etc.

[0064] Examples of ultraviolet light absorbers include para-aminobenzoic acid, ethyl para-aminobenzoate, glyceryl para-aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate, oxybenzone, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone sulfonate, sodium hydroxymethoxybenzophenone sulfonate, octyl salicylate, 4-tert-butyl-4'-methoxy-dibenzoylmethane, ferulic acid, titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide, and the like.

[0065] Examples of sequestering agents include edetic acid, edetates, trisodium ethylenediaminehydroxyethyltriacetate, diethylenetriaminepentaacetic acid, pentasodium diethylenetriaminepentaacetic acid, ethylenediaminetetrakis(2-hydroxyisopropyl) dioleate, hydroxyethanediphosphonic acid, tetrasodium hydroxyethanediphosphonate, phytic acid, and the like.

[0066] Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, d-δ-tocopherol, and the like.

[0067] Examples of pigments include azo pigments, phthalocyanine pigments, etc., and lake pigments are also used. Examples of pigments include organic pigment powders such as Pigment Red 201, Pigment Red 202, Pigment Red 205, Pigment Red 226, Pigment Red 228, Pigment Orange 203, Pigment Orange 204, Pigment Blue 404, Pigment Yellow 401, etc., and zirconium, barium or aluminum lakes such as Pigment Red 3, Pigment Red 104, Pigment Red 106, Pigment Orange 205, Pigment Yellow 4, Pigment Yellow 5, Pigment Green 3, Pigment Blue 1, etc. Examples of inorganic pigments include, for example, anhydrous silicic acid, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, zinc white, chromium oxide, chromium hydroxide, carbon black, carmine, cerium oxide, iron oxide sulfate barium, ultramarine, etc.

[0068] Examples of pH adjusters include, for example, hydrochloric acid, phosphoric acid, pyrophosphoric acid, polyphosphoric acid, metaphosphoric acid, pantothenic acid, malic acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, silicic acid, citric acid, and chemically possible salts thereof, as well as sodium hydroxide, potassium hydroxide, etc.

[0069] Examples of colorants include, for example, dyes such as Dye Blue 1, Dye Green 3, Dye Yellow 4, Dye Red 105, etc., titanium dioxide, zinc oxide, zinc white, etc.

[0070] Examples of flavoring components include, for example, tea extracts, tea distillates, sodium glutamate, etc.

[0071] Examples of antiperspirant components include, for example, zinc paraphenolsulfonate, aluminum chloride, chlorhydroxyaluminum, alum, etc.

[0072] Examples of functional components include glycyrrhizic acid and its salts, glycyrrhetinic acid, pyridoxine hydrochloride, ε-aminocaproic acid, allantoin, sodium chloride, ascorbic acid and its salts, ascorbic acid derivatives, tocopherol acetate, zeolite, sodium fluoride, sodium monofluorophosphate, stannous fluoride, polyethylene glycol, potassium nitrate, azulene sulfonic acid and its salts, aluminum lactate, hyaluronic acid, hyaluronate, heparin-like substances, nicotinamide, ascorbic acid or its salts, tranexamic acid, and the like.

[0073] [Sterilization method] According to another aspect of the present invention, there is provided a method for sterilizing microorganisms (hereinafter also referred to as "the sterilization method of the present invention") on the skin, other sites similar to the skin, such as the oral cavity, hair, etc. The sterilization method of the present invention includes applying the sterilizing composition of the present invention to a target site such as the skin, whereby microorganisms present in the target site can be suppressed, reduced, or removed. The amount of the sterilizing composition of the present invention to be applied can be, for example, 0.01 to 2 g, preferably 0.05 to 1.5 g, more preferably 0.1 to 1 g per 1 cm of the target site. 2 per, for example, 0.01 to 2 g, preferably 0.05 to 1.5 g, more preferably 0.1 to 1 g.

Examples

[0074] Hereinafter, the present invention will be described more specifically based on examples, but the present invention is not limited to these examples. In Tables 1 and 2 below, the numerical values for each component all represent mass% with respect to the total mass of the sterilizing composition.

[0075] [Preparation of sterilizing composition] At room temperature, the components shown in Tables 1 and 2 below were mixed in the amounts shown in the same tables, and the pH was adjusted to 7.0 using aqueous hydrochloric acid solution and / or aqueous sodium hydroxide solution as a pH adjuster to prepare the sterilizing compositions of Examples 1 to 18 and Comparative Examples 1 to 12.

Table 1

Table 2

[0076] [Evaluation of Persistence of Bactericidal Effect] Staphylococcus aureus NBRC13276 strain was pre-cultured at 32.5 °C for 24 hours using SCD medium "Digo" (manufactured by Fujifilm Wako Pure Chemical Corporation) to obtain a pre-cultured bacterial solution. The obtained pre-cultured bacterial solution was added to physiological saline so that the number of bacteria became 10 7 CFU / mL to obtain a test bacterial solution. Next, VITRO-SKIN (registered trademark) (manufactured by IMS) cut into 1 cm squares was placed in each well of a 24-well plate, and 1 mL of each bactericidal composition of the examples and comparative examples was dropped thereon and incubated at room temperature for 1 hour. After incubation, each bactericidal composition of the examples and comparative examples was removed, and VITRO-SKIN (registered trademark) was washed twice with 1 mL of sterilized water.

[0077] Next, 0.2 mL of the test bacterial solution obtained according to the above-described procedure was seeded onto the vitroskin and incubated at 37 °C for 1 hour. After incubation, the total amount of the test bacterial solution was serially diluted 10-fold with LP diluent "Digo" (a diluent of lectin and polysorbate 80 containing 1 g of casein peptone, 0.7 g of lecithin, 20 g of polysorbate 80, and 8.3 g of purified water per liter of purified water) (manufactured by Fujifilm Wako Pure Chemical Corporation). 1 mL of the obtained diluted solution was inoculated into mannitol salt agar medium "Nissui" (manufactured by Nissui Pharmaceutical Co., Ltd.), and the log viable cell count of Staphylococcus aureus NBRC13276 strain remaining on the VITRO-SKIN (registered trademark) was determined by the pour plate culture method. The pour plate culture method was performed by mixing and solidifying the diluted solution and the agar medium in a petri dish and culturing under aerobic conditions at 32.5 °C. The number of colonies generated after culturing was counted to obtain the log viable cell count. Based on the log viable cell count, the persistence of the bactericidal effect of each bactericidal composition was evaluated according to the following criteria. The evaluation results are shown in Tables 1 and 2. ◎: The log viable cell count is less than 5.5, and the persistence of the bactericidal effect is extremely excellent. ○: The logarithmic viable cell count is 5.5 or more and less than 5.9, and it is excellent in the persistence of the bactericidal effect. ×: The logarithmic viable cell count is 5.9 or more, and it is inferior in the persistence of the bactericidal effect.

[0078] From the results shown in Table 1, it can be seen that each bactericidal composition of Examples 1 to 18 containing all of (A) a cationic bactericide, (B) a cationic polymer, and (C) a chelating agent is excellent in the persistence of the bactericidal effect. On the other hand, it can be seen that each bactericidal composition of Comparative Examples 1 to 12 not containing at least one of (A) a cationic bactericide, (B) a cationic polymer, and (C) a chelating agent is inferior in the persistence of the bactericidal effect.

[0079] [Formulation Example] [Lotion] A lotion was prepared with the following composition. The total amount was made 100% by mass with purified water. 1. Benzalkonium chloride 0.05% 2. Polylysine 0.1% 3. Polydimethyldimethylenepyrrolidinium poly chloride 1.0% 4. Sodium citrate 0.1% 5. Sodium polyphosphate 0.1% 6. Disodium edetate 0.1% 7. Polyoxyethylene (60) hydrogenated castor oil 0.3% 8. Glycerin 5.0% 9. Dipropylene glycol 2.0% 10. Ethanol 5.0% 11. Phenoxyethanol 0.1% 12. Chlorhydroxyaluminum 3.0% 13. 1,3-Butylene glycol 3.0% Remainder of purified water Total 100%

[0080] [Cream] A cream was prepared with the following composition. The total amount was made 100% by mass with purified water. 1. Benzalkonium chloride 0.05% 2. Polylysine 0.1% 3. 1.0% of dimethyldimethylenepyrrolidinium poly chloride 4. 0.1% of sodium citrate 5. 0.1% of sodium polyphosphate 6. 0.1% of disodium edetate 7. 4.5% of sodium polyoxyethylene(10) alkyl ether phosphate 8. 2.0% of polyoxyethylene(3) alkyl ether 9. 2.0% of lipophilic glycerol monostearate 10. 2.0% of cetanol 11. 5.0% of squalane 12. 10.0% of glyceryl tri(caprylate / caprate) 13. 5.0% of 1,3-butylene glycol 14. 0.1% of phenoxyethanol 15. 10.0% of glycerin 16. 0.1% of carbomer 17. 15.0% of chlorhydroxyaluminum Remainder of purified water Total 100%

[0081] [Emulsion] An emulsion was prepared with the following composition. The total amount was made up to 100% by mass with purified water. 1. 0.05% of benzalkonium chloride 2. 0.1% of polylysine 3. 0.1% of dimethyldimethylenepyrrolidinium poly chloride 4. 0.1% of sodium citrate 5. 0.1% of sodium polyphosphate 6. 0.1% of disodium edetate 7. 1.2% of polyoxyethylene(20) behenyl ether 8. 1.2% of polyoxyethylene(60) sorbitol tetraoleate 9. 1.0% of lipophilic glycerol monostearate 10. 0.5% of cetostearyl alcohol 11. 1,3 - Butylene Glycol 6.0% 12. Glyceryl Tri(caprylate / caprate) 10.0% 13. Vegetable Squalane 3.0% 14. Isocetyl Myristate 2.0% 15. Phenoxyethanol 0.5% 16. Carbomer 0.1% 17. Xanthan Gum (1% Aqueous Solution) 10.0% 18. Potassium Hydroxide (10% Aqueous Solution) 0.47% 19. Zinc Paraphenolsulfonate 10.0% Remainder of purified water Total 100%

[0082] [Facial Wash Foam] A facial wash foam was prepared with the following composition. The total amount was made up to 100% by mass with purified water. 1. Benzalkonium Chloride 0.05% 2. Polylysine 0.1% 3. Poly(dimethyldimethylenepyrrolidinium Chloride) 1.0% 4. Acrylamide / Acrylic Acid / Dimethyl diallylammonium Chloride Copolymer Solution 0.1% 5. Sodium Citrate 0.1% 6. Sodium Polyphosphate 0.1% 7. Disodium Edetate 0.1% 8. Myristic Acid 20.0% 9. Palmitic Acid 5.0% 10. Lauric Acid Diethanolamide 3.5% 11. Polyethylene Glycol (140) Distearate 1.0% 12. Polyethylene Glycol 1500 5.0% 13. Sodium N - Lauroyl Methyl Taurate Solution 8.0% 14. Glycerin 20.0% 15. Sorbit Solution 3.0% 16. Dipotassium Glycyrrhizinate 0.3% 17. 5.3% Potassium Hydroxide 18. 0.2% Isopropylmethylphenol 19. 0.1% Fragrance Remainder of purified water Total 100%

[0083] [Scrub Agent] A scrub agent was prepared with the following composition. The total amount was made up to 100% by mass with purified water. 1. 0.05% Benzalkonium Chloride 2. 0.1% Polylysine 3. 1.0% Polydimethyldimethylenepyrrolidinium Chloride 4. 0.1% O-[2-Hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose Chloride 5. 0.1% Sodium Citrate 6. 0.1% Sodium Polyphosphate 7. 0.1% Disodium Edetate 8. 50.0% Sodium Chloride 9. 10.0% Alum 10. 10.0% Glycerin 11. 10.0% Cocamidopropyl Betaine 12. 0.1% Phenoxyethanol 13. 0.1% Fragrance Remainder of purified water Total 100%

[0084] [Hair Shampoo] A hair shampoo was prepared with the following composition. The total amount was made up to 100% by mass with purified water. 1. 0.05% Cetylpyridinium Chloride 2. 0.1% Polylysine 3. 1.0% Polydimethyldimethylenepyrrolidinium Chloride 4. 0.1% Dimethyldiallylammonium Chloride·Acrylamide Copolymer 5. 0.1% O-[2-Hydroxy-3-(trimethylammonio)propyl] hydroxyethyl cellulose chloride 6. 0.1% Sodium citrate 7. 0.1% Sodium polyphosphate 8. 0.1% Disodium edetate 9. 20.0% Sodium polyoxyethylene(3) lauryl ether sulfate 10. 10.0% Cocos amido propyl betaine solution 11. 3.5% Diethanolamine laurate 12. 1.0% Ethylene glycol distearate 13. 8.0% Sodium lauroyl sarcosinate solution 14. 0.2% Jojoba oil 15. 1.0% Glycerin 16. 0.3% Phenoxyethanol 17. 0.05% Tocopherol acetate 18. 20.0% Cationized cellulose (1% aqueous solution) 19. 0.2% Perfume Remainder of purified water Total 100%

[0085] [Toothpaste abrasive] The toothpaste abrasive was prepared with the following composition. The total amount was made up to 100% by mass with purified water. 1. 0.05% Cetylpyridinium chloride 2. 0.1% Polylysine 3. 1.0% Poly(dimethyldimethylenepyrrolidinium chloride) 4. 1.0% Vinylpyrrolidone·N,N-dimethylaminoethyl methacrylate diethyl sulfate copolymer 5. 0.1% Sodium citrate 6. 0.1% Sodium polyphosphate 7. 0.1% Disodium edetate 8. 20.0% Anhydrous calcium hydrogen phosphate 9. 20.0% Calcium hydrogen phosphate dihydrate 10. 5.0% Anhydrous silicic acid 11. Carrageenan 0.7% 12. Sodium carboxymethyl cellulose 0.3% 13. Glycerin 20.0% 14. 70% Sorbitol solution 10.0% 15. Methyl paraben 0.1% 16. Sodium lauryl sulfate 1.5% 17. Polyoxyethylene (60) hydrogenated castor oil 1.0% 18. Perfume 0.2% Remainder of purified water Total 100%

[0086] [Liquid dentifrice] A liquid dentifrice was prepared with the following composition. The total amount was made up to 100% by mass with purified water. 1. Benzalkonium chloride 0.05% 2. Polylysine 0.1% 3. Poly(dimethyldimethylenepyrrolidinium chloride) 1.0% 4. Vinylpyrrolidone / N,N-dimethylaminoethyl methacrylate diethyl sulfate copolymer 1.0% 5. Sodium citrate 0.1% 6. Sodium polyphosphate 0.1% 7. Disodium edetate 0.1% 8. Glycerin 10.0% 9. 70% Sorbitol solution 20.0% 10. Ethyl paraben 0.1% 11. Polyoxyethylene (60) hydrogenated castor oil 1.0% 12. Perfume 1.0% Remainder of purified water Total 100%

Claims

1. A bactericidal composition containing: (A) a cationic bactericide, (B) a cationic polymer, and (C) a chelating agent.

2. The bactericidal composition according to claim 1, wherein the (A) cationic bactericide contains at least one of benzalkonium chloride and cetylpyridinium chloride.

3. The bactericidal composition according to claim 1, wherein the (B) is a cationic homopolymer.

4. The bactericidal composition according to claim 3, wherein the cationic homopolymer contains at least one of polylysine and polydimethyldimethylenepyrrolidinium chloride.

5. The bactericidal composition according to claim 1, wherein the (C) contains at least one selected from the group consisting of diethylenetriaminepentaacetic acid, edetic acid, hydroxyethanediphosphonic acid, citric acid, metaphosphoric acid, polyphosphoric acid, phytic acid, and salts thereof.

6. The bactericidal composition according to claim 1, wherein the content of the (A) cationic bactericide is 0.0003 to 10% by mass based on the total mass of the bactericidal composition.

7. The bactericidal composition according to claim 1, wherein the content of the (B) cationic polymer is 0.001 to 30% by mass based on the total mass of the bactericidal composition.

8. The bactericidal composition according to claim 1, wherein the content of the (C) chelating agent is 0.001 to 30% by mass based on the total mass of the bactericidal composition.

9. The bactericidal composition according to claim 1, which is for skin, oral cavity or hair.

10. The bactericidal composition according to claim 1, which is for sustained bactericidal action.

11. The bactericidal composition according to claim 1, which is a cosmetic, a pharmaceutical composition or an oral composition.

12. The bactericidal composition according to claim 1, which is an antiperspirant, an axillary osmidrosis inhibitor, a topical skin agent, a finger disinfectant, a skin cleanser or a hair cosmetic.

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